CHI3L1

Summary

Gene Symbol: CHI3L1
Description: chitinase 3 like 1
Alias: ASRT7, CGP-39, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39, chitinase-3-like protein 1, 39 kDa synovial protein, cartilage glycoprotein 39, chitinase 3-like 1 (cartilage glycoprotein-39)
Species: human

Top Publications

  1. ncbi YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages
    Severine Letuve
    Institut National de la Santé et de la Recherche Médicale Unité 700, Physiopathology and Epidemiology of Respiratory Insufficiency, Paris, France
    J Immunol 181:5167-73. 2008
  2. pmc YKL-40, a secreted glycoprotein, promotes tumor angiogenesis
    R Shao
    Pioneer Valley Life Sciences Institute, Springfield, MA 01199, USA
    Oncogene 28:4456-68. 2009
  3. doi The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 116:126-32. 2010
  4. doi Increased YKL-40 expression in patients with carotid atherosclerosis
    Annika E Michelsen
    Research Institute for Internal Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Atherosclerosis 211:589-95. 2010
  5. pmc Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma
    Ralph A Francescone
    Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 286:15332-43. 2011
  6. pmc Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function
    Carole Ober
    University of Chicago, Chicago, IL 60637, USA
    N Engl J Med 358:1682-91. 2008
  7. ncbi YKL-40 protein levels and clinical outcome of human endometrial cancer
    C Peng
    Department of Obstetrics and Gynaecology, The First Affiliated Hospital, Harbin Medical University, Harbin, China
    J Int Med Res 38:1448-57. 2010
  8. doi Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2
    Krishna P Bhat
    Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    FEBS Lett 582:3193-200. 2008
  9. doi Elevated circulating levels of the serum acute-phase protein YKL-40 (chitinase 3-like protein 1) are a marker of obesity and insulin resistance in prepubertal children
    Ioannis Kyrgios
    4th Department of Pediatrics, Faculty of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 564 03 Thessaloniki, Greece
    Metabolism 61:562-8. 2012
  10. pmc Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, PA, USA
    Brain Pathol 22:530-46. 2012

Detail Information

Publications203 found, 100 shown here

  1. ncbi YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages
    Severine Letuve
    Institut National de la Santé et de la Recherche Médicale Unité 700, Physiopathology and Epidemiology of Respiratory Insufficiency, Paris, France
    J Immunol 181:5167-73. 2008
    ..We conclude that YKL-40 is up-regulated in COPD, in which it may contribute to tissue inflammation and remodeling by sustaining the synthesis of proinflammatory and fibrogenic chemokines and of metalloproteinases by alveolar macrophages...
  2. pmc YKL-40, a secreted glycoprotein, promotes tumor angiogenesis
    R Shao
    Pioneer Valley Life Sciences Institute, Springfield, MA 01199, USA
    Oncogene 28:4456-68. 2009
    ..These findings provide novel insights into angiogenic activities and molecular mechanisms of YKL-40 in cancer development...
  3. doi The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Schizophr Res 116:126-32. 2010
    The chitinase 3-like 1 (CHI3L1) gene acts as a cellular survival factor in response to several environmental and psychosocial stresses...
  4. doi Increased YKL-40 expression in patients with carotid atherosclerosis
    Annika E Michelsen
    Research Institute for Internal Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Atherosclerosis 211:589-95. 2010
    ..We hypothesized a role for the inflammatory protein YKL-40 in atherogenesis and plaque destabilization based on its role in macrophage activation, tissue remodeling, and angiogenesis...
  5. pmc Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma
    Ralph A Francescone
    Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 286:15332-43. 2011
    ..These findings have shed light on the mechanisms by which YKL-40 promotes tumor angiogenesis and malignancy, and thus provide a therapeutic target for tumor treatment...
  6. pmc Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function
    Carole Ober
    University of Chicago, Chicago, IL 60637, USA
    N Engl J Med 358:1682-91. 2008
    ..We hypothesized that single-nucleotide polymorphisms (SNPs) that affect YKL-40 levels also influence asthma status and lung function...
  7. ncbi YKL-40 protein levels and clinical outcome of human endometrial cancer
    C Peng
    Department of Obstetrics and Gynaecology, The First Affiliated Hospital, Harbin Medical University, Harbin, China
    J Int Med Res 38:1448-57. 2010
    ..In conclusion, high YKL-40 immuno reactivity in endometrial cancer may be associated with poor prognosis...
  8. doi Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2
    Krishna P Bhat
    Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    FEBS Lett 582:3193-200. 2008
    ..This study presents a paradigm for NF-kappaB regulation of one of its targets in a strict cell type specific manner...
  9. doi Elevated circulating levels of the serum acute-phase protein YKL-40 (chitinase 3-like protein 1) are a marker of obesity and insulin resistance in prepubertal children
    Ioannis Kyrgios
    4th Department of Pediatrics, Faculty of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 564 03 Thessaloniki, Greece
    Metabolism 61:562-8. 2012
    ..Prospective studies are needed to determine whether children with elevated YKL-40 levels are at higher risk for future cardiovascular disease...
  10. pmc Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, PA, USA
    Brain Pathol 22:530-46. 2012
    ....
  11. doi IL-6, but not TNF-α, increases plasma YKL-40 in human subjects
    Anders R Nielsen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Cytokine 55:152-5. 2011
    ..The plasma level of YKL-40 did not change during TNF-α infusion or infusion of vehicle. These data demonstrate that IL-6, but not TNF-α, has a key-role in the regulation of plasma YKL-40 levels during inflammation...
  12. ncbi Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage
    Eric Steck
    Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany
    Biochem Biophys Res Commun 299:109-15. 2002
    ..Enhanced levels of YKL-40 may, therefore, be derived from synovial cells while modulation of YKL-39 and collagen 2 expression reflected the cartilage metabolism in response to degradation...
  13. pmc Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia
    Xinzhi Zhao
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Am J Hum Genet 80:12-8. 2007
    The chitinase 3-like 1 gene (CHI3L1) is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of ..
  14. ncbi A CHI3L1 gene polymorphism is associated with serum levels of YKL-40, a novel sarcoidosis marker
    Adrian Kruit
    Department of Pulmonology, Heart Lung Centre Utrecht, St Antonius Hospital, Nieuwegein, The Netherlands
    Respir Med 101:1563-71. 2007
    ..YKL-40, a chitinase-like cartilage glycoprotein, has recently shown its potential as a marker for sarcoidosis...
  15. ncbi YKL-40 protein expression is not a prognostic marker in patients with primary breast cancer
    Anne Roslind
    Department of Oncology, Herlev University Hospital, Copenhagen, Denmark
    Breast Cancer Res Treat 112:275-85. 2008
    ..Contrary to studies on serum YKL-40 as a prognostic biomarker, a high YKL-40 expression in tumor cells was not significantly associated with DSF and OS in univariate and multivariate analyses...
  16. doi Cerebrospinal fluid chitinase 3-like 1 levels are associated with conversion to multiple sclerosis
    Manuel Comabella
    Centre d esclerosi multiple de Catalunya, CEM Cat, Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, Barcelona 08035, Spain
    Brain 133:1082-93. 2010
    ....
  17. doi The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease
    Naja Dam Mygind
    Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Inflamm Res 60:281-7. 2011
    ..The aim was to investigate the influence of statin treatment and lipid status on serum YKL-40 and Hs-CRP in patients with stable CAD...
  18. pmc Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period
    P Nyirkos
    Shriners Hospital, Joint Diseases Laboratory, Montreal, Quebec, Canada
    Biochem J 269:265-8. 1990
    ..Characterization of this 39 kDa protein may provide a useful marker for classification of connective tissue cells...
  19. ncbi High levels of serum HER-2/neu and YKL-40 independently reflect aggressiveness of metastatic breast cancer
    Benny Vittrup Jensen
    Department of Oncology, Herlev Hospital, Hvidovre Hospital, University of Copenhagen, DK 2750 Herlev Denmark
    Clin Cancer Res 9:4423-34. 2003
    ....
  20. ncbi Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes
    Anneliese D Recklies
    Joint Diseases Laboratory, Shriners Hospital for Children, McGill University, Montreal, Quebec, Canada
    J Biol Chem 280:41213-21. 2005
    Elevated levels of CHI3L1 (chitinase-3-like protein 1) are associated with disorders exhibiting increased connective tissue turnover, such as rheumatoid arthritis, osteoarthritis, scleroderma, and cirrhosis of the liver...
  21. ncbi High serum levels of YKL-40 in patients with squamous cell carcinoma of the head and neck are associated with short survival
    Anne Roslind
    Department of Oncology, Herlev Hospital, University of Copenhagen, Denmark
    Int J Cancer 122:857-63. 2008
    ..Immunohistochemical analysis showed YKL-40 expression in the malignant tumor cells. In conclusion, serum YKL-40 was demonstrated to be an independent prognostic biomarker of recurrence-free and overall survival in patients with HNSCC...
  22. doi Serum YKL-40 as a marker for cervical adenocarcinoma
    A Mitsuhashi
    Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Ann Oncol 20:71-7. 2009
    ..The current study examined the clinical usefulness of YKL-40 in detection and prognosis of uterine cervical cancer...
  23. doi Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass
    Victoria Catalan
    Metabolic Research Laboratory, Clinica Universidad de Navarra, Pamplona, Spain
    J Clin Endocrinol Metab 96:200-9. 2011
    ..Plasma YKL-40 is elevated in patients with type 2 diabetes. The potential role of visceral adipose tissue (VAT) as a significant source of YKL-40 is unknown...
  24. pmc Serum YKL-40 is a marker of prognosis and disease status in high-grade gliomas
    Fabio M Iwamoto
    The Brain Tumor Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Neuro Oncol 13:1244-51. 2011
    ..4, P< .0001). Longitudinal increases in serum YKL-40 are associated with increased risk of death in patients with glioblastomas and anaplastic gliomas. YKL-40 is also a putative indicator of disease status in these patients...
  25. pmc Cancer risk by combined levels of YKL-40 and C-reactive protein in the general population
    K H Allin
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev 2730, Denmark
    Br J Cancer 106:199-205. 2012
    ..YKL-40 and C-reactive protein (CRP) are biomarkers that may reflect cancer-related subclinical inflammation. We assessed elevated YKL-40 and CRP levels as combined risk predictors for cancer...
  26. pmc Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function
    Insa M Schmidt
    Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Soc Nephrol 24:309-19. 2013
    ..of graded times of renal ischemia revealed a direct correlation between the degree of kidney injury and both Chi3l1/Brp-39 expression in the kidney and its levels in the urine...
  27. ncbi Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease
    Gitte Kronborg
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    Scand J Infect Dis 34:323-6. 2002
    b>YKL40 is secreted by activated macrophages and neutrophils. Elevated serum concentrations of YKL40 are found in patients with diseases characterized by inflammation or ongoing fibrosis...
  28. ncbi Localization of MHC class II/human cartilage glycoprotein-39 complexes in synovia of rheumatoid arthritis patients using complex-specific monoclonal antibodies
    Peter G A Steenbakkers
    Department of Pharmacology, N V Organon, Oss, The Netherlands
    J Immunol 170:5719-27. 2003
    ..These data support a role of HC gp-39 in the local autoimmune response that leads to chronic inflammation and joint destruction...
  29. ncbi Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation
    Michael Rehli
    Department of Hematology and Oncology, University of Regensburg, 93042 Regensburg, Germany
    J Biol Chem 278:44058-67. 2003
    The protein product of the CHI3L1 gene, human cartilage 39-kDa glycoprotein (HC-gp39), is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18...
  30. doi Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism
    Mao Sheng Yang
    Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Ireland
    Biol Psychiatry 64:98-103. 2008
    Gene expression data and association analyses in two Chinese samples implicate chitinase 3-like 1 (CHI3L1), a cellular survival gene, in schizophrenia susceptibility.
  31. doi YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E
    H Tang
    Dept of Respiratory Disease, Changzheng Hospital, Shanghai, China
    Eur Respir J 35:757-60. 2010
    ....
  32. doi Association between YKL-40 and adult primary astrocytoma
    Wei Zhang
    Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province, People s Republic of China
    Cancer 116:2688-97. 2010
    ....
  33. doi Genetic polymorphisms in chitinase 3-like 1 (CHI3L1) are associated with circulating YKL-40 levels, but not with angiographic coronary artery disease in a Chinese population
    Jian Lei Zheng
    Department of Cardiology, Rui Jin Hospital, Jiaotong University School of Medicine, Shanghai, PR China
    Cytokine 54:51-5. 2011
    We sought to examine if polymorphisms in the promoter region of YKL-40 gene (CHI3L1) are associated with serum YKL-40 levels and coronary artery disease (CAD) in Chinese patients.
  34. doi Increased tissue immunoexpression of YKL-40 protein in high grade serous ovarian cancers
    Paweł Stawerski
    Department of Nephropathology, Medical University of Lodz, ul Pomorska 251, 92 213 Lodz, Poland
    Pathol Res Pract 207:573-6. 2011
    ....
  35. pmc The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease
    Andreas Hector
    Department I, Children s Hospital, University of Tubingen, Tubingen, Germany
    PLoS ONE 6:e24399. 2011
    ..YKL-40/BRP-39 levelsare increased in human and murine CF airway fluids, correlate with pulmonary function and modulate CF lung disease severity genetically. These findings suggest YKL-40 as a potential biomarker in CF lung disease...
  36. pmc Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer
    M Kawada
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Oncogene 31:3111-23. 2012
    Chitinase 3-like 1 (CHI3L1), one of the mammalian members of the chitinase family, is expressed in several types of human cancer, and elevated serum level of CHI3L1 is suggested to be a biomarker of poor prognosis in advanced cancer ..
  37. doi Chitinase 3-like 1 gene-329G/A polymorphism, plasma concentration and risk of coronary heart disease in a Chinese population
    Fangyi Xie
    Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, PR China
    Gene 499:135-8. 2012
    ..The goal of the present study was to investigate whether the chitinase-like 1 gene-329G/A variant (rs10399931) confers susceptibility to CHD, and whether it is associated with the clinical phenotype and severity of disease...
  38. pmc Association between human cartilage glycoprotein 39 (YKL-40) and arterial stiffness in essential hypertension
    Wei Hong Ma
    Department of Cardiology, the Second Hospital of Shandong University, Jinan, 250033, China
    BMC Cardiovasc Disord 12:35. 2012
    ..However, the relationship between YKL-40 and arterial stiffness in hypertensive patients has not been adequately assessed...
  39. doi Serum YKL-40 predicts long-term mortality in patients with stable coronary disease: a prognostic study within the CLARICOR trial
    Marina Harutyunyan
    Department of Medicine B, The Heart Centre, Rigshospitalet, Copenhagen University Hospital and Faculty of Health Sciences, Copenhagen, Denmark
    Immunobiology 218:945-51. 2013
    ....
  40. doi Cerebrospinal fluid level of YKL-40 protein in preclinical and prodromal Alzheimer's disease
    Anna Antonell
    Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, Barcelona, Spain
    J Alzheimers Dis 42:901-8. 2014
    ..Specifically, YKL-40 protein is increased in mild AD with respect to controls, both in cerebrospinal fluid (CSF) and plasma...
  41. ncbi Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family
    B E Hakala
    Joint Diseases Laboratory, Shriners Hospital for Crippled Children, Montreal, Quebec, Canada
    J Biol Chem 268:25803-10. 1993
    ..These observations suggest that the expression of HC gp-39 may be related to a response of these cells to an altered tissue environment...
  42. ncbi Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation
    M Rehli
    Department of Hematology and Oncology, University of Regensburg, Germany
    Genomics 43:221-5. 1997
    ..of this "marker gene," we characterized the genomic organization of the HC gp-39 gene (HGMW-approved symbol CHI3L1) and cloned its 5'-proximal promotor region. The gene is composed of 10 exons distributed over an 8-kb region...
  43. ncbi Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages
    R B Kirkpatrick
    Department of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Exp Cell Res 237:46-54. 1997
    Human cartilage glycoprotein 39 (HC gp-39) has been described as a major secreted product of cultured articular chondrocytes, synovial fibroblasts, and the osteosarcoma line MG63...
  44. ncbi Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages
    G H Renkema
    Department of Biochemistry, University of Amsterdam, Academic Medical Center, The Netherlands
    Eur J Biochem 251:504-9. 1998
    ..The possible implication of the finding for chitinolytic and chitin-binding proteins that are produced in high quantities by activated macrophages are discussed...
  45. ncbi YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization
    C Nordenbaek
    Department of Internal Medicine, Section of Rheumatology, Odense University Hospital, DK 5000 Odense, Denmark
    J Infect Dis 180:1722-6. 1999
    ....
  46. ncbi Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization
    J R Connor
    SmithKline Beecham Pharmaceuticals, Department of Bone and Cartilage Biology, King of Prussia, Pennsylvania 19406, USA
    Osteoarthritis Cartilage 8:87-95. 2000
    To examine the expression pattern of human cartilage glycoprotein 39 (HC gp-39) mRNA in human cartilage and bone.
  47. pmc YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis
    Christian Østergaard
    Division of Microbiology, Department of Research and Development, Statens Serum Institut, Copenhagen, Denmark
    Clin Diagn Lab Immunol 9:598-604. 2002
    ..In conclusion, high levels of YKL-40 in CSF are found in patients with purulent meningitis...
  48. pmc The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal-regulated kinase- and protein kinase B-mediated signalling pathways
    Anneliese D Recklies
    Joint Diseases Laboratory, Shriners Hospital for Children, 1529 Cedar Avenue, Montreal, QC, Canada H3G 1A6
    Biochem J 365:119-26. 2002
    Human cartilage glycoprotein 39 (HC-gp39) is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages...
  49. ncbi High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival
    Christina Cintin
    Department of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Denmark
    Cancer 95:267-74. 2002
    ..In the current study the authors evaluated the value of serum YKL-40 in monitoring patients with colorectal carcinoma...
  50. ncbi gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells
    Kimi C Nishikawa
    Department of Biological Sciences, 1400 Washington Avenue, University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Exp Cell Res 287:79-87. 2003
    gp38k (CHI3L1) is a secreted heparin-binding glycoprotein whose expression, in vitro, is associated with vascular smooth muscle cell (VSMC) migration and invasion into the underlying gelatinous matrix...
  51. ncbi Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39
    Fabrizia Fusetti
    Laboratory of Biophysical Chemistry, Department of Chemistry, University of Groningen, Nijenborgh 4, 9747AG Groningen, The Netherlands
    J Biol Chem 278:37753-60. 2003
    The human cartilage glycoprotein-39 (HCgp-39 or YKL40) is expressed by synovial cells and macrophages during inflammation. Its precise physiological role is unknown...
  52. ncbi HC gp-39 gene is upregulated in glioblastomas
    Katherina Shostak
    Institute of Molecular Biology and Genetics, 150 Zabolotnogo str, 03143 Kiev, Ukraine
    Cancer Lett 198:203-10. 2003
    ....
  53. ncbi Expression of YKL-40 by peritumoral macrophages in human small cell lung cancer
    Nanna Junker
    Laboratory of Experimental Oncology, Department of Molecular Pathology, University of Copenhagen, 11 Frederik V Vej, DK 2100 Copenhagen, Denmark
    Lung Cancer 48:223-31. 2005
    ..No YKL-40 mRNA expression was found in the cancer cells, in macrophages infiltrating the solid tumor areas, or in non-malignant tissue. In conclusion, the predominant source of elevated serum YKL-40 in SCLC is peritumoral macrophages...
  54. ncbi YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma
    Christopher E Pelloski
    Department of Radiation Oncology, Neuro Oncology, and Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:3326-34. 2005
    ..Here we test these findings in a larger series of patients with glioblastoma, and in particular, determine if tumor YKL-40 expression is associated with radiation response...
  55. ncbi Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma
    Christopher E Pelloski
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:3935-41. 2006
    ..This study was conducted to determine whether any of these markers are associated with survival time and response to radiation in glioblastoma...
  56. ncbi YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis
    C N Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Inflamm Res 55:221-7. 2006
    ..This article reviews the studies of YKL-40 with focus on a possible role of YKL-40 in insulin resistance, endothelial dysfunction and atherosclerosis...
  57. ncbi YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas
    Adilia Hormigo
    Clinical Laboratories, Neurosurgical Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Clin Cancer Res 12:5698-704. 2006
    ..We obtained prospective longitudinal serum samples from patients with gliomas to determine whether YKL-40 or MMP-9 could be used as serum markers...
  58. ncbi Changes of biochemical markers of bone turnover and YKL-40 following hormonal treatment for metastatic prostate cancer are related to survival
    Julia S Johansen
    Department of Rheumatology, Herlev Hospital, Denmark
    Clin Cancer Res 13:3244-9. 2007
    ..In this study, we evaluated the value of these biomarkers in monitoring the patients during hormonal treatment...
  59. ncbi Increased expression of the inflammatory protein YKL-40 in precancers of the breast
    Wenyi Qin
    Department of Surgery University of Missouri, Columbia, MO 65121, USA
    Int J Cancer 121:1536-42. 2007
    ..NAF levels of YKL-40 are significantly higher in women with precancers than healthy subjects, suggesting that measuring YKL-40 in NAF may improve the identification of women at increased breast cancer risk...
  60. ncbi YKL-40 protein expression in the early developing human musculoskeletal system
    Julia S Johansen
    Department of Rheumatology, Q 107, Herlev Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    J Histochem Cytochem 55:1213-28. 2007
    ..This indicates that YKL-40 is associated with cell proliferation, differentiation, and tissue morphogenesis during development of the human musculoskeletal system...
  61. ncbi Experimental anti-angiogenesis causes upregulation of genes associated with poor survival in glioblastoma
    Ahlame Saidi
    ELAT European Laboratory for Angiogenesis and Translational Research, INSERM U920 ex E0113, Talence, F 33405, France
    Int J Cancer 122:2187-98. 2008
    ..CHI3L2, IL1B, PI3/elafin and CHI3L1, which encodes for YKL-40, a putative prognosticator for various diseases, including cancer, were strongly up-..
  62. doi Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia
    Mine Kucur
    Fikret Biyal Central Research Laboratory, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Urol Oncol 26:47-52. 2008
    ..YKL-40, a growth factor for connective tissue cells, a migration factor for endothelial and vascular smooth muscle cells, is expressed by several types of solid human carcinoma, including prostate carcinoma...
  63. doi Serum levels of YKL-40 increases in patients with acute myocardial infarction
    Camilla Nøjgaard
    Department of Gastroenterology, Hvidovre Hospital, Denmark
    Coron Artery Dis 19:257-63. 2008
    ..The aim was to examine the sequential changes in serum YKL-40 in patients with acute myocardial infarction (AMI), with and without thrombolytic therapy, as compared with patients with stable coronary artery disease (CAD)...
  64. doi Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein
    Mayumi Kawada
    Gastrointestinal Unit, Department of Medicine, Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lab Invest 88:883-95. 2008
    ..We previously reported that chitinase 3-like-1 (CHI3L1) enhances bacterial adhesion and invasion on/into colonic epithelial cells (CECs)...
  65. doi YKL-40 a new biomarker in patients with acute coronary syndrome or stable coronary artery disease
    Yongzhong Wang
    Medical Department B, Cardiac Catheterization Laboratory, The Heart Centre, Rigshospitalet, University Hospital Copenhagen, Faculty of Health Sciences, University of Copenhagen, Denmark
    Scand Cardiovasc J 42:295-302. 2008
    ..Aim was to quantitate plasma YKL-40 in patients with ST-elevation myocardial infarction (STEMI) or stable chronic coronary artery disease (CAD), and YKL-40 gene activation in human myocardium...
  66. pmc Plasma YKL-40: a BMI-independent marker of type 2 diabetes
    Anders R Nielsen
    Department of InfectiousDiseases, Facultyof Health Sciences, Centre of Inflammation and Metabolism, Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Diabetes 57:3078-82. 2008
    ..YKL-40 is produced by macrophages, and plasma YKL-40 is elevated in patients with diseases characterized by inflammation. In the present study, YKL-40 was examined in relation to obesity, inflammation, and type 2 diabetes...
  67. pmc YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 32:323-8. 2009
    ..In the present study, YKL-40 levels were examined in patients with type 1 diabetes with increasing levels of albuminuria, known to be associated with an increased risk of cardiovascular disease...
  68. ncbi Chitinase 3-Like-1 (CHI3L1): a putative disease marker at the interface of proteomics and glycomics
    Frederick D Coffman
    Department of Pathology, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    Crit Rev Clin Lab Sci 45:531-62. 2008
    Chitinase 3-Like-1 (CHI3L1) is a secreted 40 kDa glycoprotein that is upregulated in a number of human cancers and in non-neoplastic disease states characterized by chronic inflammation and tissue remodeling...
  69. doi A functional variation in CHI3L1 is associated with severity of liver fibrosis and YKL-40 serum levels in chronic hepatitis C infection
    Marie Luise Berres
    Department of Internal Medicine III, University Hospital Aachen, RWTH Aachen, Pauwelsstr 30, D 52057 Aachen, Germany
    J Hepatol 50:370-6. 2009
    ..We assessed whether a functional promoter polymorphism in CHI3L1, encoding YKL-40, is associated with HCV-induced liver fibrosis and influences YKL-40 serum concentrations.
  70. doi Genetic variation in the promoter region of chitinase 3-like 1 is associated with atopy
    Myung Hyun Sohn
    Department of Pediatrics and Institute of Allergy, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea
    Am J Respir Crit Care Med 179:449-56. 2009
    ..Aberrant expression of chitinase 3-like 1 (CHI3L1), also known as YKL-40 or HC gp-39, is involved in the pathogenesis of inflammatory and allergic diseases.
  71. pmc Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e5469. 2009
    ..The aim of the present study was to investigate the putative association between SNPs and haplotype blocks of CHI3LI and T2D and T2D related quantitative traits...
  72. ncbi Expression and clinical significance of YKL-40 protein in epithelial ovarian cancer tissues
    Guo fen Yang
    Department of Gynecology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Ai Zheng 28:142-5. 2009
    ..Moreover, YKL-40 expression is closely related to clinical phenotypes of some malignant tumors. This study was to investigate the expression and clinical significance of YKL-40 protein in epithelial ovarian cancer tissues...
  73. pmc Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults
    Camilla Noelle Rathcke
    Department of Endocrinology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e6106. 2009
    YKL-40 is a chitinase-like glycoprotein encoded by the chitinase 3-like 1 gene, CHI3L1, localized at chromosome 1q32.1. Increased levels of serum YKL-40 have been reported to be a biomarker for asthma and a reduced lung function...
  74. pmc The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases
    Carole Ober
    Department of Human Genetics, The University of Chicago, Illinois 60636, USA
    Curr Opin Allergy Clin Immunol 9:401-8. 2009
    ..chitotriosidase (CHIT1), YKL-40, and acid mammalian chitinase, and summarizes the genetic studies of asthma and immune-mediated diseases with polymorphisms in the genes encoding these proteins, CHIT1, CHI3L1, and CHIA, respectively.
  75. doi YKL-40 secreted from adipose tissue inhibits degradation of type I collagen
    Takeo Iwata
    Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8504, Japan
    Biochem Biophys Res Commun 388:511-6. 2009
    ..These results suggest that macrophage/preadipocyte interaction enhances degradation of type I collagen in AT, meanwhile, YKL-40 secreted from macrophages infiltrating into AT inhibits the type I collagen degradation...
  76. doi Overexpression of YKL-40 is an independent prognostic marker in gastric cancer
    Jiong Bi
    Laboratory of Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Hum Pathol 40:1790-7. 2009
    ..These results suggest that overexpression of YKL-40 is correlated with the aggressive behavior of tumor cells, which could be used as an independent molecular marker for the predicting poor prognosis of patients with gastric cancer...
  77. doi Plasma YKL-40 is elevated in patients with recurrent atrial fibrillation after catheter ablation
    Kristoffer Mads Henningsen
    Department of Cardiology, Cardiac Catheterization Laboratory 2014, The Heart Centre, Rigshospitalet, University of Copenhagen, 2100 Copenhagen Ø, Denmark
    Inflamm Res 59:463-9. 2010
    ..To study plasma YKL-40 in patients with atrial fibrillation (AF) treated with radiofrequency (RF) catheter ablation and to assess the predictive role of plasma YKL-40 and its changes after restoration of sinus rhythm (SR)...
  78. doi Increased serum YKL-40 and C-reactive protein levels are associated with angiographic lesion progression in patients with coronary artery disease
    Jian Lei Zheng
    Department of Cardiology, Rui Jin Hospital, Jiaotong University School of Medicine, Shanghai 200025, PR China
    Atherosclerosis 210:590-5. 2010
    ..This study aimed to assess the possible association between YKL-40 and coronary lesion progression in CAD patients...
  79. pmc YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas
    Craig Horbinski
    Department of Pathology, Division of Neuropathology, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    Int J Clin Exp Pathol 3:226-37. 2010
    ..3), but loss of heterozygosity in 10q23 correlated with increased YKL-40 expression (P = 0.03). These data suggest that YKL-40 is predominantly expressed by neoplastic glial cells and is related to certain key molecular alterations...
  80. doi Lack of evidence for association of two functional SNPs of CHI3L1 gene (HC-gp39) with rheumatoid arthritis
    Sanjeev K Srivastava
    Department of Genetics, Cell and Immunobiology, Semmelweis University, Nagyvarad ter 4, 1089, Budapest, Hungary
    Rheumatol Int 31:1003-7. 2011
    b>CHI3L1 gene encodes for a glycoprotein (HC-gp39 or YKL40) secreted by synovial fibroblasts, macrophages, neutrophil granulocytes and chondrocytes. Its expression is under the control of NF-kB...
  81. doi CHI3L1 (YKL-40) is expressed in human gliomas and regulates the invasion, growth and survival of glioma cells
    Bo Mi Ku
    Department of Anatomy and Neurobiology, Institute of Health Science, School of Medicine, Gyeongsang National University, Jinju, South Korea
    Int J Cancer 128:1316-26. 2011
    Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that has pleiotropic activity in aggressive cancers. In our study, we examined the expression and function of CHI3L1 in glioma cells...
  82. pmc In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    J Neuroinflammation 7:34. 2010
    b>CHI3L1 (YKL-40) is up-regulated in a variety of inflammatory conditions and cancers...
  83. pmc Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema
    Hiroshi Matsuura
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    Am J Respir Cell Mol Biol 44:777-86. 2011
    ..These studies also underscore that maintaining physiologic concentrations of YKL-40 in the lung is therapeutically important in preventing excessive inflammatory responses or emphysematous alveolar destruction...
  84. doi A promoter polymorphism -2122C>T of CHI3L1 is associated with serum low density lipoprotein cholesterol level in Korean subjects
    Haeyong Lee
    Department of Microbiology, Chung Ang University College of Medicine, Seoul, Republic of Korea
    Clin Biochem 43:1195-200. 2010
    This study assessed the effects of 10 tagging single nucleotide polymorphisms (SNPs) of the CHI3L1 gene on serum LDL cholesterol levels in 290 Korean subjects.
  85. doi Plasma YKL-40 levels in healthy subjects from the general population
    Stig E Bojesen
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Denmark
    Clin Chim Acta 412:709-12. 2011
    ..Plasma YKL-40 is a new biomarker in patients with cancer and inflammatory diseases. High plasma YKL-40 is associated with poor prognosis. Our aim was to determine reference levels in healthy subjects...
  86. pmc Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects
    Kaspar R Nielsen
    Department of Clinical Immunology, Aalborg Hospital, Aarhus University Hospital, Reberbansgade, Pobox 561, 9000, Aalborg, Denmark
    Arthritis Res Ther 13:R109. 2011
    ..study investigates the association between single nucleotide polymorphisms (SNPs) in the chitinase 3-like 1 (CHI3L1) gene and serum concentrations of YKL-40 in Danish patients with rheumatoid arthritis (RA) and healthy controls as ..
  87. pmc Breast cancer expression of YKL-40 correlates with tumour grade, poor differentiation, and other cancer markers
    R Shao
    Pioneer Valley Life Sciences Institute, 3601 Main Street, Springfield, MA 01199, USA
    Br J Cancer 105:1203-9. 2011
    ..However, the tissue expression of YKL-40 and its relationship with clinical outcomes and other potential markers are poorly understood...
  88. pmc A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40
    Sandeep K Singh
    Department of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Biol Chem 286:39893-903. 2011
    ..We propose that NFI-X3 and STAT3 control the migration of differentiating astrocytes as well as migration and invasion of glioma cells via regulating YKL-40 expression...
  89. pmc YKL-40 is differentially expressed in human embryonic stem cells and in cell progeny of the three germ layers
    Christian B Brøchner
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Histochem Cytochem 60:188-204. 2012
    ....
  90. ncbi YKL-40 expression in human hepatocellular carcinoma: a potential biomarker?
    Xin Qiang Xiao
    Liver Diseases Center, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Hepatobiliary Pancreat Dis Int 10:605-10. 2011
    ..This study aimed to examine the expression of YKL-40 in the serum and liver tissues of HCC patients and in HCC cell lines, in comparison with that in non-HCC liver disease patients and non-tumor hepatic cell lines, respectively...
  91. doi The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failure
    Marina Harutyunyan
    Department of Medicine B, The Heart Centre, Rigshospitalet, Copenhagen University Hospital and Faculty of Health Sciences, Denmark
    Immunobiology 217:652-6. 2012
    ....
  92. doi Levels of YKL-40 in pleural effusions and blood from patients with pulmonary or pleural disease
    Hak Ryul Kim
    Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Republic of Korea
    Cytokine 58:336-43. 2012
    ....
  93. doi YKL-40 is elevated in patients with peripheral arterial disease and diabetes or pre-diabetes
    Klaudija Batinic
    Division of Pediatric Cardiology, University Zurich, Switzerland
    Atherosclerosis 222:557-63. 2012
    ..Experimental in vivo and in vitro data suggest a role of YKL-40 in tissue remodeling. A disease modulating potency of YKL-40 was not investigated in peripheral arterial disease (PAD)...
  94. doi Significant association of elevated concentration of plasma YKL-40 with disease severity in patients with pelvic inflammatory disease
    Shu Hsin Lee
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    J Clin Lab Anal 26:136-42. 2012
    ..To date, no study reports the implication of YKL-40 in pelvic inflammatory disease (PID). Therefore, we investigate the levels of plasma YKL-40 in patients with PID and further associate its expression with the severity of disease...
  95. pmc Variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and prediction of fatal and non-fatal ischemic stroke
    Camilla Noelle Rathcke
    Deptartment of Internal Medicine, Center of Endocrinology and Metabolism, Copenhagen University Hospital Herlev, Copenhagen, Denmark
    PLoS ONE 7:e43498. 2012
    Polymorphisms of CHI3L1 are associated with inter-individual YKL-40 levels and YKL-40 is associated with an increased mortality and is elevated in patients with cardiovascular disease...
  96. pmc High YKL-40 serum concentration is correlated with prognosis of Chinese patients with breast cancer
    Dong Wang
    Department of General Surgery, the Fourth Hospital of Harbin Medical University, Harbin, China
    PLoS ONE 7:e51127. 2012
    ..We propose that the potential utility of YKL-40 intratumoral staining or serum concentration as a biomarker for breast cancer is greatest within 5 years of diagnosis...
  97. pmc Serum YKL-40 levels correlate with infarct volume, stroke severity, and functional outcome in acute ischemic stroke patients
    Hyun Young Park
    Department of Neurology, School of Medicine, Wonkwang University, Iksan, Korea
    PLoS ONE 7:e51722. 2012
    ..We aimed to identify the temporal changes and clinical usefulness of measuring serum YKL-40 immediately following AIS...
  98. doi YKL-40 expression could be a poor prognostic marker in the breast cancer tissue
    Eun Joo Kang
    Division of Medical Oncology, Department of Internal Medicine, Korea University, Guro Hospital 97 Gurodong gil, Guro Ku, Seoul, Korea
    Tumour Biol 35:277-86. 2014
    ....
  99. doi Genetic variants in CHI3L1 influencing YKL-40 levels: resequencing 900 individuals and genotyping 9000 individuals from the general population
    Alisa D Kjaergaard
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Herlev, Denmark
    J Med Genet 50:831-7. 2013
    ..Therefore, we aimed at identifying genetic variants in CHI3L1 influencing plasma YKL-40 levels in the general population.
  100. pmc Serum YKL-40 level is associated with the chemotherapy response and prognosis of patients with small cell lung cancer
    Chun hua Xu
    First Department of Respiratory Medicine and Nanjing Chest Hospital, Nanjing, Jiangsu, China Clinical Center of Nanjing Respiratory Diseases, Nanjing, Jiangsu, China
    PLoS ONE 9:e96384. 2014
    ..016 and p = 0.041, respectively). These results suggest that YKL-40 is a potential prognostic marker of chemotherapy response in SCLC. ..
  101. ncbi Etanercept exerts beneficial effects on articular cartilage biomarkers of degradation and turnover in patients with ankylosing spondylitis
    Walter P Maksymowych
    Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Rheumatol 32:1911-7. 2005
    ..The low sensitivity to change over time of plain radiographic instruments mandates a search for the effects of these therapies on possible biomarkers of cartilage damage...

Research Grants25

  1. TFE3 and TFEB in CD40L Dependent Murine Autoimmunity and Human Lupus
    CHRISTOPHER AJ ROMAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): CD40L (CD154;gp39) is a critical effector molecule of activated T cells, necessary for production of isotype switched and affinity matured antibodies by B cells, and macrophage and dendritic cell ..
  2. BRP-39/YKL-40 in Th2 Inflammation and Asthma
    Jack A Elias; Fiscal Year: 2013
    ..This proposal will investigate the processes that regulate the production of this molecule and define the receptor, signaling pathways and mechanisms that it uses to regulate cell death. ..
  3. METABOLISM OF THE TRABECULAR MESHWORK
    David L Epstein; Fiscal Year: 2011
    ..of HTM cells is characterized by high levels of expression of the gene encoding for chitinase 3-like 1 (CHI3L1), a protein known to inhibit the production of proinflammatory cytokines...
  4. Role of CHI3L1 in accelerating breast cancer metastasis
    VIJAYA L IRAGAVARAPU-CHARYULU; Fiscal Year: 2013
    ..High levels of CHI3L1 are found in asthma and breast cancer with even higher levels when these diseases are present together...
  5. Role of Mammalian Chitinases in Inflammatory Bowel Disease
    Emiko Mizoguchi; Fiscal Year: 2013
    ..We have recently identified a novel, intestinal inflammation-associated inducible molecule Chitinase 3-like-1 (CHI3L1) that is produced by colonic epithelial cells (CECs) and lamina propria cells...
  6. Positive and Negative Regulatory Pathways In Human Lymphoma
    Richard Ford; Fiscal Year: 2007
    ..Signalosome appears to be initiated through autochthonous production and cognate ligand binding of CD154 (CD40L, gp39) to the CD40 receptor on the lymphoma cell surface...
  7. Protein folding by the universally conserved GroEL (Hsp60) chaperone machine and
    Costa Georgopoulos; Fiscal Year: 2013
    ..Using this basic life or death genetic system, we have identified Gp39.2, a GroEL chaperone regulator also encoded by the T4-like phages. However, in contrast to Gp31, Gp39...
  8. ANTIRAT CD40L EFFECTS ON ISLET ALLOGRAFT SURVIVAL
    Karen Kover; Fiscal Year: 1999
    ..The monoclonal antibody, anti-CD40L (gp39), is of interest because it has shown to be effective in controlling auto-immune disease as well as well as ..
  9. AUTOIMMUNE T-CELL MECHANISMS IN INTERSTITIAL NEPHRITIS
    Carolyn Kelly; Fiscal Year: 1999
    ..The second receptor-ligand couple they will study is that of CD40 and the CD40L (gp39). The CD40L is expressed on the T cell surface only transiently following activation...
  10. SELF-TOLERANCE DEFECTS IN DRUG-INDUCED AUTOIMMUNITY
    Robert Rubin; Fiscal Year: 1999
    ..The T cell dependency of the autoantibody response will be tested by introducing anti-CD4 and anti-gp39 antibodies in vivo, which are known to interfere with immune responses mediated by T-helper cells...
  11. ASSEMBLY/REGULATION OF CD40 RECEPTOR COMPLEX IN B CELLS
    Randolph Noelle; Fiscal Year: 2001
    DESCRIPTION (Adapted from the Investigator's abstract): Interactions of CD40 and its ligand (CD154, CD40L, gp39) control the development of humoral and cell-mediated immune responses...
  12. HUMAN CARTILAGE GP39 IN HLA-DR4 TRANSGENIC MURINE MODEL
    Thomas Forsthuber; Fiscal Year: 2003
    ..This essential information cannot be obtained by testing conventional mouse strains, nor through human studies, but it can readily be obtained through the use of humanized mice as proposed in this study. ..
  13. T CELL COST IMMULATION ON MURINE LUPUS
    DAVID DAIKH; Fiscal Year: 2001
    ..T cell costimulation can also be provided by interactions between CD4O and its cognate ligand gp39, but the role of these molecules in autoimmunity is also unknown...
  14. Regulatory Role of TNFR1 in Inflammatory Bowel Disease
    Emiko Mizoguchi; Fiscal Year: 2007
    ..In Aim II, we will examine the role of Chitinase 3-like-1 (CHI3L1) that may negatively regulate the TNFR1 signalings during the acute and following recovery phase of colitis...
  15. CONTROL OF B CELL TERMINAL DIFFERENTIATION--ROLE OF CD40
    Troy Randall; Fiscal Year: 2003
    ..We will first examine how CD40/gp39 interactions influence B cell differentiations in a previously established in vitro co-culture system and then ..
  16. Innate and adaptive Treg in Immune tolerization of RA
    Salvatore Albani; Fiscal Year: 2005
    ..properties of "innate" and "adaptive" Treg on T cell responses to recall antigens as well as to antigens (gp39, dnaJP1 and p205) putatively involved in the pathogenic process...
  17. BIOLOGY OF IL-16 IN IL-1680 AND IL-1614 TRANSGENIC MICE
    Geoffrey Chupp; Fiscal Year: 2003
    ..These finding swill have impressive implications via-a-vis our knowledge of the biology of IL-16 and mechanisms of airway inflammation and healing in asthma. ..
  18. Human Lung gamma/delta T cells, Antigens and Functions
    ADAM WISNEWSKI; Fiscal Year: 2004
    ..The results of these experiments should provide important insights into the role of airway mucosal gamma/delta T cells in maintaining human pulmonary immune homeostasis. ..
  19. Isocyanate Antigens and T-cells that Cause Asthma
    ADAM WISNEWSKI; Fiscal Year: 2005
    ..Together the results should provide significant insights into the pathogenesis of diisocyanate asthma. ..
  20. Macrophage Protein Fingerprints in HIV-1 Dementia
    Pawel Ciborowski; Fiscal Year: 2006
    ..The long-term goal of this aim is to uncover biomarkers specific for HAD and to see if they are based on products of immune competent virus-infected MDM as demonstrated in aim 1. ..
  21. Immunity to versican and ankylosing spondylitis
    Yiping Zhang; Fiscal Year: 2007
    ..We also intend to identify the role of HLA-B27 in the pathogenesis of the VGI/model using human HLA-B*2705 transgenic animals. ..
  22. New Serodiagnostics for Isocyanate Exposure, A Major Cause of Occupational Asthma
    ADAM WISNEWSKI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  23. GENETICS OF AUTOIMMUNITY
    BRIAN KOTZIN; Fiscal Year: 2003
    ..Taken together, the investigator suggests that the results of the studies proposed in this application will provide new insight into the genes that allow for autoimmune disease in SLE and the intermediate phenotypes that they control. ..
  24. Genetic Factors Controlling Effector Function of TGF-beta in COPD and Fibrosis
    Chun Geun Lee; Fiscal Year: 2011
    ..AIM #4. Define the genes that determine whether TGF-b1 induceds a predominantly fibrotic versus emphysematous response in C57BL/6 and Balb/c mice. ..