CH25H

Summary

Gene Symbol: CH25H
Description: cholesterol 25-hydroxylase
Alias: C25H, cholesterol 25-hydroxylase, cholesterol 25-monooxygenase, h25OH
Species: human

Top Publications

  1. doi EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells
    Florian Wanke
    Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany
    Cell Rep 18:1270-1284. 2017
  2. doi Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages
    Inga Preuss
    Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Biochem Biophys Res Commun 446:663-8. 2014
  3. pmc 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling
    Elizabeth S Gold
    Seattle Biomedical Research Institute, Seattle, WA 98109 and
    Proc Natl Acad Sci U S A 111:10666-71. 2014
  4. pmc Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
    Andrea Reboldi
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Science 345:679-84. 2014
  5. doi Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity
    F Chalmin
    Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, 1211 Geneva 14, Switzerland Department of Pathology and Immunology, University of Geneva, 1211 Geneva 4, Switzerland
    J Autoimmun 56:45-55. 2015
  6. pmc Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms
    Yongzhi Chen
    1 CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China 2 University of Chinese Academy of Sciences, Beijing, China
    Sci Rep 4:7242. 2014
  7. pmc Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis
    Hongjin Lu
    Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    Steroids 99:219-29. 2015
  8. pmc Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection
    Yu Xiang
    Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Virol 89:6805-16. 2015
  9. doi Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation
    - Anggakusuma
    Institute of Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany
    Hepatology 62:702-14. 2015
  10. pmc Differential Expression Profile of Chicken Embryo Fibroblast DF-1 Cells Infected with Cell-Adapted Infectious Bursal Disease Virus
    Raymond K Hui
    School of Biological Sciences, The University of Hong Kong, Hong Kong, People s Republic of China
    PLoS ONE 10:e0111771. 2015

Scientific Experts

  • Alan Aderem
  • Timothy J Green
  • Ken Dutton-Regester
  • Nicholas Smith
  • Matthias Riemenschneider
  • Carla Bittencourt
  • Christopher Carter
  • Melissa L Burke
  • Jing Huan Wang
  • Christoph Hock
  • Dietmar Rudolf Thal
  • M Axel Wollmer
  • Andreas W Sailer
  • Inga Preuss
  • Jason G Cyster
  • Tangsheng Yi
  • Yu Su
  • Florian Wanke
  • Min Feng
  • Jiho Jang
  • Punya Shrivastava-Ranjan
  • Daria Trabattoni
  • Zewen Kelvin Tuong
  • Aleksandra Rutkowska
  • Amanda L Forwell
  • Yu Xiang
  • Hongjin Lu
  • - Anggakusuma
  • F Chalmin
  • Raymond K Hui
  • Takayuki Tsujioka
  • Patrick Lau
  • Jeremy C Yeo
  • Jin Zhong
  • Jennifer L Stow
  • George E O Muscat
  • Steven Watterson
  • Kevin A Robertson
  • Yongzhi Chen
  • Juan Zhang
  • Andrea Reboldi
  • Elizabeth S Gold
  • Isabelle Christen
  • Simon Talbot
  • Peter Ghazal
  • Thorsten Forster
  • Genhong Cheng
  • Lishan Su
  • Roghiyh Aliyari
  • Mathieu Blanc
  • Tomohiro Ichikawa
  • Zewen K Tuong
  • Steven E Trasino
  • David W Russell
  • Gerald Eibinger
  • Su Yang Liu
  • Klaus Seuwen
  • Francois Gessier
  • Xiaoyan Liu
  • Lisa M Kelly
  • Tie Zou
  • Sébastien Hannedouche
  • Geoffroy Laumet
  • Joshua C Denny
  • Kiwon Park
  • Lars Bertram
  • Ulf Diczfalusy
  • Brit Maren M Schjeide
  • Jean Charles Lambert
  • Philippe Amouyel
  • A R Morgan
  • Nobuto Shibata
  • Andreas Papassotiropoulos
  • Avraham Ben-Nun
  • Julia Bruttger
  • Denise Tischner
  • Tanja Kuhlmann
  • Morad Zayoud
  • Zhenjie Zhu
  • Nir Yogev
  • Andrew L Croxford
  • Xuejie Zhang
  • Florian C Kurschus
  • Klaus Rajewsky
  • Yingjie Wang
  • Nina Wettschureck
  • Sonja Moos
  • Aisong Guo
  • Nicole Israel
  • Khalad Karram

Detail Information

Publications50

  1. doi EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells
    Florian Wanke
    Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany
    Cell Rep 18:1270-1284. 2017
    ..EBI2 and its ligand, 7α,25-OHC, direct immune cell localization in secondary lymphoid organs. CH25H and CYP7B1 hydroxylate cholesterol to 7α,25-OHC...
  2. doi Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages
    Inga Preuss
    Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Biochem Biophys Res Commun 446:663-8. 2014
    ..human macrophages express EBI2 and the enzymes needed for ligand production such as cholesterol 25-hydroxylase (CH25H), sterol 27-hydroxylase (CYP27A1), and oxysterol 7α-hydroxylase (CYP7B1)...
  3. pmc 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling
    Elizabeth S Gold
    Seattle Biomedical Research Institute, Seattle, WA 98109 and
    Proc Natl Acad Sci U S A 111:10666-71. 2014
    ..Surprisingly, we found that deletion of Ch25h, the gene encoding the enzyme responsible for 25HC production, is protective in a mouse model of influenza ..
  4. pmc Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
    Andrea Reboldi
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Science 345:679-84. 2014
    ..Here, we report that activated mouse macrophages lacking the IFN-stimulated gene cholesterol 25-hydroxylase (Ch25h) and that are unable to produce the oxysterol 25-hydroxycholesterol (25-HC) overproduce inflammatory interleukin-1 ..
  5. doi Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity
    F Chalmin
    Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, 1211 Geneva 14, Switzerland Department of Pathology and Immunology, University of Geneva, 1211 Geneva 4, Switzerland
    J Autoimmun 56:45-55. 2015
    ..The enzyme cholesterol 25 hydroxylase (Ch25h) is the rate limiting step to synthesize the oxysterol 7α,25-dihydroxycholesterol (7α,25-OHC) ..
  6. pmc Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms
    Yongzhi Chen
    1 CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China 2 University of Chinese Academy of Sciences, Beijing, China
    Sci Rep 4:7242. 2014
    Cholesterol 25-hydroxylase (CH25H) as an interferon-stimulated gene (ISG) has recently been shown to exert broad antiviral activity through the production of 25-hydroxycholesterol (25HC), which is believed to inhibit the virus-cell ..
  7. pmc Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis
    Hongjin Lu
    Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom
    Steroids 99:219-29. 2015
    ..the synthesis of 25-Hydroxycholesterol (25-HC) from cholesterol by the IFN-inducible Cholesterol-25-Hydroxylase (CH25H)...
  8. pmc Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection
    Yu Xiang
    Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Virol 89:6805-16. 2015
    ..In this study, we showed that 25HC and its synthesizing enzyme cholesterol 25-hydroxylase (CH25H) efficiently inhibit HCV infection at a postentry stage...
  9. doi Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation
    - Anggakusuma
    Institute of Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany
    Hepatology 62:702-14. 2015
    ..Recent studies have reported that cholesterol 25-hydroxylase (CH25H) is expressed as an interferon-stimulated gene and mediates antiviral activities against different enveloped ..
  10. pmc Differential Expression Profile of Chicken Embryo Fibroblast DF-1 Cells Infected with Cell-Adapted Infectious Bursal Disease Virus
    Raymond K Hui
    School of Biological Sciences, The University of Hong Kong, Hong Kong, People s Republic of China
    PLoS ONE 10:e0111771. 2015
    ..Over-expression of LIPA and CH25H, together with the suppression of STARD4, LSS and AACS genes implied a modulation of membrane fluidity and lipid ..
  11. doi OsHV-1 countermeasures to the Pacific oyster's anti-viral response
    Timothy J Green
    Department of Biological Sciences, Macquarie University, NSW, 2109, Australia Sydney Institute of Marine Science, Chowder Bay Road, Mosman, NSW, 2088, Australia Electronic address
    Fish Shellfish Immunol 47:435-43. 2015
    ..gigas inhibitors of apoptosis (IAPs) and an interferon-stimulated gene (termed CH25H). The first objective of this study was to simultaneously investigate the expression of C...
  12. pmc Five-aza-2'-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells
    Takayuki Tsujioka
    Department of Laboratory Medicine, Kawasaki Medical School, Okayama 701 0192, Japan
    Sci Rep 5:16709. 2015
    ..Hence, we performed a genome-wide DNA methylation assay and focused on cholesterol 25-hydroxylase (CH25H) among the genes whose expression was up-regulated and whose promoter region was hypomethylated after decitabine (..
  13. pmc RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages
    Zewen Kelvin Tuong
    Institute for Molecular Bioscience, The University of Queensland, Brisbane QLD 4072, Australia
    PLoS ONE 11:e0147179. 2016
    ..previously shown that BMMs from sg/sg mice have significantly decreased expression of cholesterol 25-hydroxylase (Ch25h) mRNA, the enzyme that produces the oxysterol, 25-hydroxycholesterol (25HC), and now confirm this at the protein ..
  14. pmc Analysis of CH25H in multiple sclerosis and neuromyelitis optica
    Amanda L Forwell
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    J Neuroimmunol 291:70-2. 2016
    Oxysterols produced by CH25H during cholesterol metabolism have been shown to play an important role in the immune response...
  15. ncbi The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems
    Aleksandra Rutkowska
    School of Medicine, Dept of Physiology, Trinity College Dublin, 152 160 Pearse Street, Ireland
    Curr Drug Targets . 2016
    ..We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system...
  16. pmc Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication
    Daria Trabattoni
    Department of Biomedical and Clinical Sciences L Sacco, University of Milano, Italy
    Sci Rep 6:27148. 2016
    ..genes (ISGs), including those involved in cholesterol pathway, particularly the cholesterol-25 hydroxylase (CH25H)...
  17. pmc 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
    Jiho Jang
    Department of Physiology and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea
    Nat Commun 7:13129. 2016
    ..Here, we identify the aberrant production of cholesterol 25-hydroxylase (CH25H) and 25-hydroxycholesterol (25-HC) in the cellular context of CCALD based on the analysis of ALD patient-derived ..
  18. pmc Endogenous Retrovirus ev21 Dose Not Recombine with ALV-J and Induces the Expression of ISGs in the Host
    Min Feng
    Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural UniversityGuangzhou, China Guangdong Provincial Key Lab of Agro Animal Genomics and Molecular Breeding and Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of AgricultureGuangzhou, China
    Front Cell Infect Microbiol 6:140. 2016
    ..the expression of PKR at 6h post ALV-J infection (hpi) and facilitate the expression of ISG12 and CH25H at 24 hpi. However, the expression of the env gene of M180 strain was not significantly at 6 and 24 hpi...
  19. pmc Macrophage migration inhibitory factor activates inflammatory responses of astrocytes through interaction with CD74 receptor
    Yu Su
    Key Laboratory of Neuroregeneration, Ministry of Education and Jiangsu Province, Co innovation Center of Neuroregeneration, Nantong University, Nantong 226001, PR China
    Oncotarget 8:2719-2730. 2017
    ..Transcriptome analysis revealed that inflammation-related factors cholesterol 25-hydroxylase (Ch25h) and phospholipase A2-IIA (Pla2g2a), downstream of MIF/CD74 axis, were potentially implicated in the mediating ..
  20. pmc 25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation
    Punya Shrivastava-Ranjan
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    MBio 7:. 2016
    ..The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC)...
  21. pmc The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response
    Mathieu Blanc
    Division of Pathway Medicine and Edinburgh Infectious Diseases, University of Edinburgh, Edinburgh EH16 4SB, UK
    Immunity 38:106-18. 2013
    ..analyses, genetic interventions and chromatin immunoprecipitation experiments that Stat1 directly coupled Ch25h regulation to IFN in macrophages...
  22. doi Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high-fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages
    Steven E Trasino
    U S Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics, and Immunology Laboratory, 10300 Baltimore Avenue, BARC East, Bldg 307C, Rm 225, Beltsville, MD 20705
    J Nutr Biochem 24:1931-9. 2013
    ..LPS stimulation of AM opposed LXR agonist-mediated transcription of cholesterol metabolism related genes: ABCA1, CH25H and PPARγ in pigs on the C diet, and LXRα, ABCA1, ABCG1, CH25H and PPARγ in pigs on the HF diet...
  23. pmc On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment
    Gerald Eibinger
    Institute of Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21, Graz 8010, Austria
    Exp Cell Res 319:1828-38. 2013
    ..Here, we investigated expression and transcriptional regulation of cholesterol 25-hydroxylase (CH25H) in human U87MG and GM133 glioblastoma cell lines...
  24. doi 25-hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway
    Tomohiro Ichikawa
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Exp Cell Res 319:1176-86. 2013
    ..25-hydroxycholesterol (25-HC) is enzymatically produced by cholesterol 25-hydorxylase (CH25H) in macrophages and is reported to be involved in the formation of arteriosclerosis...
  25. pmc Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol
    Su Yang Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Immunity 38:92-105. 2013
    ..We identified cholesterol-25-hydroxylase (CH25H) as a broadly antiviral ISG...
  26. ncbi Ultrastructural studies of lethal c25H/C25H mouse embryos
    M D Nadijcka
    J Embryol Exp Morphol 52:1-11. 1979
    Mouse embryos which are homozygous for the c25H deletion at the albino locus are developmentally arrested at the 2- to 6-cell cleavage stages...
  27. pmc Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses
    Tangsheng Yi
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Immunity 37:535-48. 2012
    ..7α,25-OHC is synthesized from cholesterol by the stepwise actions of two enzymes, CH25H and CYP7B1, and is metabolized to a 3-oxo derivative by HSD3B7...
  28. doi Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice
    Zewen K Tuong
    The University of Queensland, Institute for Molecular Bioscience, Brisbane, Queensland 4072, Australia
    Endocrinology 154:140-9. 2013
    ..Notably, we identified decreased expression of the mRNA encoding cholesterol 25-hydroxylase (Ch25h), an enzyme that converts cholesterol to 25-hydroxycholesterol (25HC), an oxysterol with emerging roles in ..
  29. doi Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene
    Ken Dutton-Regester
    Queensland Institute of Medical Research, Oncogenomics Laboratory, Brisbane QLD 4006, Australia
    Genes Chromosomes Cancer 51:452-61. 2012
    ..Because of their likely functional significance for melanoma progression, FAS, CH25H, BMPR1A, ACTA2, and TFG were investigated in a larger cohort of melanomas through sequencing...
  30. pmc Assignment of genes to regions of mouse chromosomes
    E M Eicher
    Proc Natl Acad Sci U S A 75:946-50. 1978
    ..and Giemsa banding analysis of the T(X;7)1Ct and T(7;19)145H translocations together with information from the c25H deletion have permitted mouse chromosome 7 to be divided into six and chromosome 19 into two definable genetic ..
  31. pmc Association study of candidate gene polymorphisms with amnestic mild cognitive impairment in a Chinese population
    Xiaoyan Liu
    School of Clinical Medicine, Southeast University, Nanjing, China
    PLoS ONE 7:e41198. 2012
    ..G and TOMM40 rs2075650 G), to the cholesterol metabolism hypothesis (ApoE rs429358 C, LDLR rs11668477 G and CH25H rs7091822 T and PLAU rs2227564 CT) and to the tau hypothesis (MAPT/STH rs242562 GG) in aMCI were significantly ..
  32. pmc Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
    Ulf Diczfalusy
    Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    J Lipid Res 50:2258-64. 2009
    ..treatment of bone marrow-derived mouse macrophages, it was unexpectedly found that cholesterol 25-hydroxylase (Ch25h) was strongly upregulated...
  33. ncbi cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
    E G Lund
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
    J Biol Chem 273:34316-27. 1998
    ....
  34. ncbi Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease
    M Riemenschneider
    Department of Psychiatry, Neurochemistry and Neurogenetics Laboratory, TU München Ismaningerstr 22, 81675 Munchen, Germany
    Neurobiol Aging 25:1305-8. 2004
    ..of genes located on chromosome 10 involved in cholesterol metabolism, like Lipase A (LIPA), Cholesterol 25 hydroxylase (CH25H), and FLJ22476, a high density lipoprotein binding related protein...
  35. ncbi ToF-SIMS characterization of thermal modifications of bixin from Bixa orellana fruit
    Carla Bittencourt
    Laboratoire Interdisciplinaire de Spectroscopie Electronique, Falcultés Universitaires Notre Dame de la Paix, 61 rue de Bruxelles, B 5000 Namur, Belgium
    J Agric Food Chem 53:6195-200. 2005
    ..The intensity of the peak at m/z 396, assigned to the bixin molecular ion plus two hydrogen atoms (C25H(32)O(4+), decreased as the extract was heated and nearly disappeared with heating above 150 degrees C...
  36. ncbi Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease
    Nobuto Shibata
    Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ont, Canada M5S 3H2
    Neurosci Lett 391:142-6. 2006
    ..genes as candidates for AD risk factors: ATP-binding cassette transporter A1 (ABCA1), cholesterol 25-hydroxylase (CH25H) and cholesterol 24-hydroxylase (CH24H)...
  37. ncbi Regulation of cholesterol 25-hydroxylase expression by vitamin D3 metabolites in human prostate stromal cells
    Jing Huan Wang
    Department of Anatomy, Medical School, 33014 University of Tampere, Tampere, Finland
    Biochem Biophys Res Commun 345:720-5. 2006
    ..Cholesterol 25-hydroxylase (CH25H) is an enzyme converting cholesterol into 25-hydroxycholesterol...
  38. ncbi Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease
    Andreas Papassotiropoulos
    Division of Psychiatry Research, University of Zurich, Zurich, Switzerland
    Neurodegener Dis 2:233-41. 2005
    ..We observed high expression of the cholesterol 25-hydroxylase (CH25H) gene in specifically vulnerable brain regions of AD patients...
  39. ncbi Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis
    C J Carter
    Neurochem Int 50:12-38. 2007
    ..ABCA2, lipoprotein receptors LDLR, LRP1, LRP8 and VLDLR, and the cholesterol metabolising enzymes CYP46A1 and CH25H, whose oxysterol products activate the liver X receptor NR1H2 and are metabolised to esters by SOAT1...
  40. ncbi Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease
    A R Morgan
    Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK
    Am J Med Genet B Neuropsychiatr Genet 144:762-70. 2007
    ..DKK1, ZWINT, ANK3, UBE2D1, CDC2, SIRT1, JDP1, NET7, SUPV3L1, NEN3, SAR1, SGPL1, SEC24C, CAMK2G, PP3CB, SNCG, CH25H, PLCE1, ANXV111) in the MRC genetic resource for LOAD...
  41. pmc Assessment of Alzheimer's disease case-control associations using family-based methods
    Brit Maren M Schjeide
    MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurogenetics 10:19-25. 2009
    ..In this study, we tested 27 genes (ACE, BDNF, CH25H, CHRNB2, CST3, CTSD, DAPK1, GALP, hCG2039140, IL1B, LMNA, LOC439999, LOC651924, MAPT, MTHFR, MYH13, PCK1, PGBD1, ..
  42. doi Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study
    Geoffroy Laumet
    INSERM U744, Lille, France
    J Alzheimers Dis 20:1181-8. 2010
    ..Ten genes/loci (TFAM, SORL1, CHRNB2, SORCS1, DAPK1, MTHFR, GWA 14q32.13, BDNF, NEDD9, and CH25H) showed weak nominal association with AD risk, in line with previous studies...
  43. pmc Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium
    Nicholas L Smith
    Cardiovascular Health Study Department of Epidemiology, University of Washington, Seattle, WA 98105, USA
    Circ Cardiovasc Genet 3:256-66. 2010
    ....
  44. doi Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease
    Dietmar Rudolf Thal
    Institute of Pathology, University of Ulm, Albert Einstein Allee 11, Ulm, Germany
    Acta Neuropathol 120:169-83. 2010
    ....
  45. doi Cholesterol-related genes in Alzheimer's disease
    M Axel Wollmer
    Psychiatric University Clinics, University of Basel, 4025 Basel, Switzerland
    Biochim Biophys Acta 1801:762-73. 2010
    ..Among 34 cholesterol-related genes for which association with AD has been described APOE, CH25H, CLU, LDLR, SORL1 outstand with positive meta-analyses...
  46. pmc Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
    Kiwon Park
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Leukoc Biol 88:1081-7. 2010
    The oxysterol-producing enzyme CH25H plays an important role in regulating lipid metabolism, gene expression, and immune activation...
  47. pmc Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science
    Joshua C Denny
    Office of Personalized Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 0575, USA
    Circulation 122:2016-21. 2010
    ..The extent to which this can be demonstrated in cohorts derived from electronic medical records is unknown...
  48. pmc Listeria monocytogenes infection induces prosurvival metabolic signaling in macrophages
    Tie Zou
    Program in Gene Function and Expression and Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Infect Immun 79:1526-35. 2011
    ..25-Hydroxycholesterol is a natural ligand of LXRs that is produced by the enzyme cholesterol 25-hydroxylase (CH25H). We found that expression of Ch25h is upregulated following L...
  49. pmc Oxysterols direct immune cell migration via EBI2
    Sébastien Hannedouche
    Euroscreen s a, 6041 Gosselies, Belgium
    Nature 475:524-7. 2011
    ..A critical enzyme required for the generation of 7α,25-OHC is cholesterol 25-hydroxylase (CH25H)...
  50. doi Migrating Schistosoma japonicum schistosomula induce an innate immune response and wound healing in the murine lung
    Melissa L Burke
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane 4006, Australia
    Mol Immunol 49:191-200. 2011
    ..response is associated with significant up-regulation of several genes with immunoregulatory function including Ch25h, Hmox1 and Retnla which may act to control the nature or magnitude of the inflammatory response to the migrating ..