CFB

Summary

Gene Symbol: CFB
Description: complement factor B
Alias: AHUS4, ARMD14, BFD, CFAB, CFBD, FBI12, GBG, H2-Bf, PBF2, complement factor B, B-factor, properdin, C3 proaccelerator, C3 proactivator, C3/C5 convertase, glycine-rich beta-glycoprotein, properdin factor B
Species: human

Top Publications

  1. doi Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease
    Ann E Ostvik
    Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway Department of Gastroenterology and Hepatology, St Olav s University Hospital, Trondheim, Norway Department of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway Department of Pathology and Medical Genetics, St Olav s University Hospital, Trondheim, Norway Research Laboratory, Department of Laboratory Medicine, Nordland Hospital, Bodø, Norway Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway K G Jebsen IRC, University of Oslo, Oslo, Norway and Department of Infectious Diseases, St Olav s University Hospital, Trondheim, Norway
    Inflamm Bowel Dis 20:995-1003. 2014
  2. pmc Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
    Bert Gold
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Nat Genet 38:458-62. 2006
  3. ncbi Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
    Hum Mol Genet 16:1986-92. 2007
  4. ncbi Variation in complement factor 3 is associated with risk of age-related macular degeneration
    Julian B Maller
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 39:1200-1. 2007
  5. pmc C3 R102G polymorphism increases risk of age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    Hum Mol Genet 17:1821-4. 2008
  6. doi Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy
    Kelvin Y Lee
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 49:2613-9. 2008
  7. pmc Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:2044-53. 2009
  8. doi Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology
    Naoshi Kondo
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Ophthalmology 116:1502-9. 2009
  9. doi The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration
    Inderjeet Kaur
    Hyderabad Eye Research Foundation, Champalimaud Translational Centre, Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 51:59-63. 2010
  10. doi A novel mutation in the complement factor B gene (CFB) and atypical hemolytic uremic syndrome
    Hanan Tawadrous
    Division of Pediatric Nephrology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Pediatr Nephrol 25:947-51. 2010

Research Grants

  1. Baerbel Rohrer; Fiscal Year: 2014
  2. Wei Chao; Fiscal Year: 2015
  3. SIBLING STUDY OF AGE-RELATED MACULAR DEGENERATION
    Margaret M DeAngelis; Fiscal Year: 2010
  4. 5-HT1A receptor anti-apoptotic transduction pathways in suicide
    Victoria Arango; Fiscal Year: 2013
  5. MELVIN EDWARD MEDOF; Fiscal Year: 2015
  6. Margaret A Pericak-Vance; Fiscal Year: 2014
  7. William K Scott; Fiscal Year: 2015
  8. Jeremy B Sokolove; Fiscal Year: 2015
  9. Mechanisms of injury and acute repair of axons in TBI
    Ramesh Raghupathi; Fiscal Year: 2012
  10. Kevin R Regner; Fiscal Year: 2015

Detail Information

Publications304 found, 100 shown here

  1. doi Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease
    Ann E Ostvik
    Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway Department of Gastroenterology and Hepatology, St Olav s University Hospital, Trondheim, Norway Department of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway Department of Pathology and Medical Genetics, St Olav s University Hospital, Trondheim, Norway Research Laboratory, Department of Laboratory Medicine, Nordland Hospital, Bodø, Norway Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway K G Jebsen IRC, University of Oslo, Oslo, Norway and Department of Infectious Diseases, St Olav s University Hospital, Trondheim, Norway
    Inflamm Bowel Dis 20:995-1003. 2014
    ..Screening TLR3-agonist response in an intestinal epithelial cell line, we found complement factor B mRNA (CFB) potently upregulated and went on to further study localization of complement factor B synthesis ..
  2. pmc Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
    Bert Gold
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
    Nat Genet 38:458-62. 2006
    ..These data expand and refine our understanding of the genetic risk for AMD...
  3. ncbi Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
    Hum Mol Genet 16:1986-92. 2007
    ..Recently, polymorphisms in the factor B (CFB) and complement component 2 (CC2) genes were associated with decreased susceptibility to AMD...
  4. ncbi Variation in complement factor 3 is associated with risk of age-related macular degeneration
    Julian B Maller
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 39:1200-1. 2007
    ..We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample...
  5. pmc C3 R102G polymorphism increases risk of age-related macular degeneration
    Kylee L Spencer
    Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    Hum Mol Genet 17:1821-4. 2008
    ..Association of variants in the complement factor H (CFH) and complement factor B (CFB) genes has targeted the search for additional loci to the alternative complement cascade, of which C3 ..
  6. doi Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy
    Kelvin Y Lee
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 49:2613-9. 2008
    ..Variants in the C2 and BF genes have been found to confer a significantly reduced risk of AMD. This study was undertaken to determine whether these associations occur in Chinese patients with PCV...
  7. pmc Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:2044-53. 2009
    ..The joint effects of genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed...
  8. doi Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology
    Naoshi Kondo
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Ophthalmology 116:1502-9. 2009
    ..in 4 tightly linked genes of the major histocompatibility complex class III--complement component 2 (C2), complement factor B (CFB), RD RNA-binding protein (RDBP), and superkiller viralicidic activity 2-like (SKIV2L)--are associated ..
  9. doi The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration
    Inderjeet Kaur
    Hyderabad Eye Research Foundation, Champalimaud Translational Centre, Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 51:59-63. 2010
    Genes involved in the complement cascade such as complement factor B (CFB) and complement component C2 have been implicated in age-related macular degeneration (AMD) worldwide...
  10. doi A novel mutation in the complement factor B gene (CFB) and atypical hemolytic uremic syndrome
    Hanan Tawadrous
    Division of Pediatric Nephrology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Pediatr Nephrol 25:947-51. 2010
    We report the case of an 8-year-old girl diagnosed with atypical hemolytic uremic syndrome (aHUS) with a complement factor B (CFB) gene mutation. aHUS is a disease of complement dysregulation...
  11. pmc Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy
    Luiz H Lima
    The Vitreous, Retina, Macula Consultants of New York and the LuEsther T Mertz Retina Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, USA
    Ophthalmology 117:1567-70. 2010
    ..To investigate the frequency of variants in 3 major age-related macular degeneration (AMD)-associated loci in patients of European-American descent with polypoidal choroidal vasculopathy (PCV)...
  12. pmc Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    Wei Chen
    Center for Statistical Genetics, Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:7401-6. 2010
    ..Our results validate AMD susceptibility loci near CFH (P < 10(-75)), ARMS2 (P < 10(-59)), C2/CFB (P < 10(-20)), C3 (P < 10(-9)), and CFI (P < 10(-6))...
  13. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD...
  14. doi Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population
    Xiaoqi Liu
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
    Retina 30:1177-84. 2010
    ..Genetic variants, single-nucleotide polymorphisms (SNPs), in these genes were geno-typed for a case-control association study in a mainland Han Chinese population...
  15. doi Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population
    Isao Nakata
    Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Invest Ophthalmol Vis Sci 53:794-8. 2012
    To determine whether genetic variants in the complement component 2 and factor B gene (C2/CFB) locus are associated with the risk for typical age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV) in a Japanese ..
  16. pmc Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3
    Valentina Cipriani
    Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Hum Mol Genet 21:4138-50. 2012
    ..7 × 10(-72)), CFH (complement factor H) (P =2.3 × 10(-47)), C2 (complement component 2)-CFB (complement factor B) (P =5.2 × 10(-9)), C3 (complement component 3) (P =2.2 × 10(-3)) and CFI (P =3...
  17. ncbi Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration
    Kelly M Loyet
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Invest Ophthalmol Vis Sci 53:6628-37. 2012
    ..To determine if the progression of age-related macular degeneration (AMD) is associated with complement activation in the eye...
  18. pmc Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population
    Beatriz Buentello-Volante
    Department of Genetics and Research Unit, Institute of Ophthalmology Conde de Valenciana Mexico City, Mexico
    Mol Vis 18:2518-25. 2012
    ..association of age-related macular degeneration (AMD)-high risk alleles of the complement factor H (CFH), complement factor B (CFB), complement component 2 (C2), complement component 3 (C3), and age-related maculopathy susceptibility ..
  19. doi Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration
    Gareth J McKay
    Centre for Vision Sciences, Queen s University of Belfast, Belfast, Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 50:533-9. 2009
    ..Previous studies have identified polymorphisms in the complement component 2 (CC2) and factor B (CFB) genes, as potential functional variants associated with AMD, in particular CFB R32Q and CC2 rs547154, both of ..
  20. ncbi Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population
    Jie Chu
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Chin Med J (Engl) 121:2525-33. 2008
    ..to replicate the associations of representative polymorphisms in three genes (complement factor H (CFH), complement factor B (BF) and HtrA serine peptidase 1 (HTRA1)) with exudative age-related macular degeneration (AMD) in a Han ..
  21. pmc Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B
    Tamara Montes
    Consejo Superior de Investigaciones Cientificas, Centro de Investigación Biomédica en Red de Enfermedades Raras and Fundación Renal Iñigo Alvarez de Toledo, Ramiro de Maeztu 9, 28040 Madrid, Spain
    Proc Natl Acad Sci U S A 106:4366-71. 2009
    ..Knowledge of the functional consequences of polymorphisms in complement activators and regulators will aid disease prediction and inform targeting of diagnostics and therapeutics...
  22. pmc Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort
    Gareth J McKay
    Centre for Vision and Vascular Sciences, Queen s University of Belfast, Belfast, Northern Ireland BT12 6BA, UK
    Mol Vis 16:194-9. 2010
    ..We assess its effect on AMD risk in a Northern Irish sample, test for gene-gene and gene-environment interaction, and review a risk prediction model...
  23. doi Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis
    Mei Chen
    Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, UK
    Eur J Immunol 40:2870-81. 2010
    We have shown previously that complement factor H (CFH) and complement factor B (CFB) are constitutively expressed by retinal pigment epithelial cells and their production is regulated by inflammatory cytokines, suggesting that the ..
  24. pmc aHUS caused by complement dysregulation: new therapies on the horizon
    Aoife M Waters
    Department of Nephrology, Great Ormond Street Hospital, London, WC1N 3JH, UK
    Pediatr Nephrol 26:41-57. 2011
    ..factor H-related proteins (CFHR), and membrane cofactor protein (MCP)], as well as complement activators [complement factor B (CFB) and C3]...
  25. doi Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome
    Tara K Maga
    Interdepartmental PhD Program in Genetics, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hum Mutat 31:E1445-60. 2010
    ..complement factor H (CFH), complement factor H-related 5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD)...
  26. pmc The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Prog Retin Eye Res 29:95-112. 2010
    ..genes including: Complement factor H (CFH), complement factor H-related 1 and 3 (CFHR1 and CFHR3), complement factor B (CFB), complement component 2 (C2), and complement component 3 (C3)...
  27. doi Characterization of the sheep Complement Factor B gene (CFB)
    Jinyi Qin
    School of Biomedical Sciences, Curtin Health Innovation Research Institute, Western Australian Biomedical Research Institute, Curtin University, GPO Box U1987, Perth, 6845 Western Australia, Australia
    Vet Immunol Immunopathol 140:170-4. 2011
    The Complement Factor B gene (CFB) of the alternative complement pathway has been identified in the sheep Major Histocompatibility Complex (MHC) and its genomic sequence determined...
  28. ncbi Age-related macular degeneration: a perspective on genetic studies
    N Patel
    Laser and Retinal Research Unit, Kings College Hospital, London, UK
    Eye (Lond) 22:768-76. 2008
    ..Age-related macular degeneration (AMD) is a common macular disease in the developed world and recent studies have shown that specific genes may be associated with it and may contribute to a higher risk of developing AMD...
  29. doi Application of champedak mannose-binding lectin in the glycoproteomic profiling of serum samples unmasks reduced expression of alpha-2 macroglobulin and complement factor B in patients with nasopharyngeal carcinoma
    Ramarao Seriramalu
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Electrophoresis 31:2388-95. 2010
    ..Reduced expression of alpha-2 macroglobulin (AMG) and complement factor B (CFB) was detected in sera of patients with nasopharyngeal carcinoma (NPC) when pooled serum samples of the ..
  30. pmc Lack of association of CFD polymorphisms with advanced age-related macular degeneration
    Jiexi Zeng
    Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, China
    Mol Vis 16:2273-8. 2010
    ..Typically, complement factor H (CFH), complement factor B (CFB), complement component 2 (C2), and complement component 3 (C3) are associated with AMD...
  31. pmc Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects
    Kyu Hyung Park
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Mol Vis 15:200-7. 2009
    ..This study was performed to replicate the association between SERPING1 and AMD...
  32. ncbi Recombinant cobra venom factor
    Carl Wilhelm Vogel
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Mol Immunol 41:191-9. 2004
    ....
  33. ncbi Complement regulatory proteins in glomerular diseases
    M Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    Kidney Int 54:1419-28. 1998
    ..Systemic administration of soluble recombinant complement regulatory proteins and local overexpression of complement regulatory proteins are promising therapeutic approaches...
  34. doi Genetic deficiency of complement factor H in a patient with age-related macular degeneration and membranoproliferative glomerulonephritis
    Tamara Montes
    Centro de Investigaciones Biológicas and Centro de Investigación Biomédica en Enfermedades Raras, Ramiro de Maeztu 9, Madrid, Spain
    Mol Immunol 45:2897-904. 2008
    ..Genetic analyses of the CFH, CFB, C3, CFHR1-CFHR3 and LOC387715/HTRA1 genes revealed that the patient was heterozygote for a novel missense mutation ..
  35. ncbi The use of signature sequences in different proteins to determine the relative branching order of bacterial divisions: evidence that Fibrobacter diverged at a similar time to Chlamydia and the Cytophaga-Flavobacterium-Bacteroides division
    E Griffiths
    Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
    Microbiology 147:2611-22. 2001
    ..as well as in homologues from species belonging to the Chlamydia and Cytophaga-Flavobacterium- Bacteroides (CFB) groups, but it is not found in homologues from any other groups of bacteria. The presence of this insert in F...
  36. ncbi Limited selection of sodium channel blocking toxin-producing bacteria from paralytic shellfish toxin-contaminated mussels (Aulacomya ater)
    Monica Vasquez
    Laboratorio de Biotecnologia, INTA Universidad de Chile, Santiago, Chile
    Res Microbiol 153:333-8. 2002
    ..types detected clustered with species of the y-Proteobacteria subclass, the Cytophaga-Flexibacter-Bacteroides (CFB), the Fusobacteria and the Firmicutes phyla...
  37. ncbi Isolation, characterization and comparison of bacteria from swine faeces and manure storage pits
    Michael A Cotta
    Fermentation Biotechnology Research Unit, National Center for Agricultural Utilization Research, USDA, Agricultural Research Service, Peoria, IL 61604, USA
    Environ Microbiol 5:737-45. 2003
    ..Isolates similar to Sporomusa and Flexibacter/Cytophaga/Bacteroides (CFB or Bacteroidetes) groups were also obtained...
  38. pmc Epiphytic bacterial community composition on two common submerged macrophytes in brackish water and freshwater
    Melanie Hempel
    Limnology, Department of Biology, University of Konstanz, PO Box 659, D 78457 Konstanz, Germany
    BMC Microbiol 8:58. 2008
    ..in two habitats, freshwater (Lake Constance) and brackish water (Schaproder Bodden), using fluorescence in situ hybridization. The bacterial community composition was analysed based on habitat, plant species, and plant part...
  39. pmc Selective modification of rat hepatic microsomal fatty acid chain elongation and desaturation by fibrates: relationship with peroxisome proliferation
    M Alegret
    , Facultad de Farmacia, , Barcelona, Spain
    Br J Pharmacol 114:1351-8. 1995
    1. The time-course of the effect of clofibrate (CFB), bezafibrate (BFB) and gemfibrozil (GFB) on lipid plasma levels and palmitoyl-, palmitoleoyl- and gamma-linolenoyl-CoA elongase, delta-9, delta-6 and delta-5 desaturase activities, and ..
  40. pmc Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibrates
    M Alegret
    , Facultad de Farmacia, , Barcelona, Spain
    Br J Pharmacol 112:551-6. 1994
    1. The time-course of the effect of clofibrate (CFB), bezafibrate (BFB) and gemfibrozil (GFB) on lipid plasma levels and palmitoyl-CoA hydrolase and synthetase activities, as well as the correlations with the peroxisomal proliferation ..
  41. doi Characterization of the bacterial communities associated with the bald sea urchin disease of the echinoid Paracentrotus lividus
    Pierre T Becker
    Laboratoire de Biologie Marine, Universite de Mons Hainaut, 6 Avenue du Champ de Mars, 7000 Mons, Belgium
    J Invertebr Pathol 98:136-47. 2008
    ..24 bacterial genomospecies in bald sea urchin lesions: 5 are Alphaproteobacteria, 10 are Gammaproteobacteria, 8 are CFB bacteria and 1 is a Fusobacteria...
  42. doi Microbial diversity of a sulfide black smoker in main endeavour hydrothermal vent field, Juan de Fuca Ridge
    Huaiyang Zhou
    Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, P R China
    J Microbiol 47:235-47. 2009
    ..Clones of Proteobacteria (gamma-, delta-, beta-), Cytophaga-Flavobacterium-Bacteroides (CFB) and Deinococcus-Thermus occurred as well...
  43. ncbi Endophytic bacterial diversity in rice (Oryza sativa L.) roots estimated by 16S rDNA sequence analysis
    Lei Sun
    College of Life Sciences, Capital Normal University, Beijing 100037, People s Republic of China
    Microb Ecol 55:415-24. 2008
    ..of alpha, beta, gamma, delta, and epsilon subclasses of the Proteobacteria, Cytophaga/Flexibacter/Bacteroides (CFB) phylum, low G+C gram-positive bacteria, Deinococcus-Thermus, Acidobacteria, and archaea...
  44. doi Localized complement activation in the development of protective immunity against Ostertagia ostertagi infections in cattle
    Robert W Li
    Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture, Beltsville, MD 20705, USA
    Vet Parasitol 174:247-56. 2010
    ..Increased mRNA levels of complement components C3, factor B (CFB) and factor I (CFI) in the abomasal mucosa of the infected cattle were confirmed using quantitative PCR while ..
  45. ncbi Poles apart: biodiversity and biogeography of sea ice bacteria
    J T Staley
    Department of Microbiology 357242, University of Washington, Seattle 98195, USA
    Annu Rev Microbiol 53:189-215. 1999
    ..bacteria fall into four major phylogenetic groups: the proteobacteria, the Cytophaga-Flavobacterium-Bacteroides (CFB) group, and the high and low mol percent gram-positive bacteria...
  46. ncbi [Bacterial diversity of disused thermal vents in Tibetan Yangbajing Region]
    Bin Chen
    Tibetan Plateau Institute of Biology, Lhasa 850001, China
    Wei Sheng Wu Xue Bao 49:217-26. 2009
    ..To study the bacterial diversity in sediment and water from two disused thermal vents in Yangbajing, Tibet, China...
  47. pmc Prevalence of Cardinium bacteria in planthoppers and spider mites and taxonomic revision of "Candidatus Cardinium hertigii" based on detection of a new Cardinium group from biting midges
    Yuki Nakamura
    National Institute of Agrobiological Sciences, Owashi, Tsukuba, Ibaraki 305 8634, Japan
    Appl Environ Microbiol 75:6757-63. 2009
    Cardinium bacteria, members of the phylum Cytophaga-Flavobacterium-Bacteroides (CFB), are intracellular bacteria in arthropods that are capable of inducing reproductive abnormalities in their hosts, which include parasitic wasps, mites, ..
  48. ncbi Biochemical and chemical characterization of trifluoromethylglyoxal bis(guanylhydrazone), a close analog of the antileukemic drug mitoguazone
    H Elo
    Department of Chemistry, University of Helsinki, Finland
    Z Naturforsch C 43:601-5. 1988
    ..of bis(guanylhydrazone) type polyamine antimetabolites, trifluoromethylglyoxal bis(guanylhydrazone) (CF3-GBG), a close analog of the antileukemic drug methylglyoxal bis(guanylhydrazone) (mitoguazone, MGBG) was synthesized ..
  49. pmc The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization
    Barbel Rohrer
    Department of Ophthalmology, Medical University of South Carolina, Charleston, SC 29425, United States
    Mol Immunol 48:e1-8. 2011
    ..Proteins encoded by the AMD risk genes participate in the AP (CFB), CP/LP (C2), or in the AP and final common pathway (C3)...
  50. ncbi Bacterial population structure of the jute-retting environment
    Tulika K Munshi
    Department of Microbiology and Biotechnology Center, Faculty of Science, M S University of Baroda, Baroda, Gujarat, 390002, India
    Microb Ecol 56:270-82. 2008
    ..of clones from the divisions-Firmicutes ( approximately 11, 12%), Cytophaga-Flexibacter-Bacteroidetes group (CFB; approximately 9, 7%), Verrucomicrobia ( approximately 6, 5%), Acidobacteria ( approximately 4, 5%), Chlorobiales ( ..
  51. pmc A mitochondrial-like aconitase in the bacterium Bacteroides fragilis: implications for the evolution of the mitochondrial Krebs cycle
    Anthony D Baughn
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 99:4662-7. 2002
    ..fragilis aconitase is most closely related to aconitases of two other Cytophaga-Flavobacterium-Bacteroides (CFB) group bacteria, Cytophaga hutchinsonii and Fibrobacter succinogenes...
  52. doi Planktonic bacteria and fungi are selectively eliminated by exposure to marine macroalgae in close proximity
    Cindy Lam
    Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Oldenburg, Germany
    FEMS Microbiol Ecol 63:283-91. 2008
    ..and fungi was analyzed with selective oligonucleotide probes targeting the Cytophaga/Flavobacterium/Bacteroides (CFB), Alphaproteobacteria and Roseobacter group and the ITS1 region of marine fungi...
  53. ncbi Benzoylformate decarboxylase from Pseudomonas putida as stable catalyst for the synthesis of chiral 2-hydroxy ketones
    H Iding
    , , , Germany
    Chemistry 6:1483-95. 2000
    The thiamin diphosphate- and Mg2+-dependent enzyme benzoylformate decarboxylase (BFD) from Pseudomonas putida was characterized with respect to its suitability to catalyze the formation of chiral 2-hydroxy ketones in a benzoin-..
  54. doi Microbial community variation and functions to excess sludge reduction in a novel gravel contact oxidation reactor
    Shanshan Lin
    School of Urban and Environmental Science, Northeast Normal University, Changchun, China
    J Hazard Mater 165:1083-90. 2009
    ..those related to the beta-Proteobacteria group, then gamma-Proteobacteria and to Cytophaga-Flexibacter-Bacteriode (CFB)...
  55. ncbi Eliminating complement factor D reduces photoreceptor susceptibility to light-induced damage
    Barbel Rohrer
    Department of Neurosciences Division of Research, Medical University of South Carolina, Charleston, SC 29425, USA
    Invest Ophthalmol Vis Sci 48:5282-9. 2007
    Genetic risk factors such as variations in complement factors H (CFH) and B (CFB) have been implicated in the etiology of age-related macular degeneration...
  56. ncbi Isolation, phylogenetic analysis and screening of marine mollusc-associated bacteria for antimicrobial, hemolytic and surface activities
    Lyudmila A Romanenko
    Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Prospect 100 let Vladivostoku, 159, Russian Federation
    Microbiol Res 163:633-44. 2008
    ..and Alphaproteobacteria, and Less with Firmicutes, Actinobacteria, and Cytophaga-Flavobacterium-Bacteroides (CFB) group...
  57. ncbi [Phylogenetic analysis of bacterial diversity in Pacific Arctic sediments]
    Hui Rong Li
    SOA Key Laboratory for Polar Science, Polar Research Institute of China, Shanghai 200136, China
    Wei Sheng Wu Xue Bao 46:177-83. 2006
    ..domain Bacteria: alpha- beta-, gamma-, delta-, epsilon- Proteobacteria, the Cytophaga-Flavobacterium-Bacteroides (CFB) group and Actinobacteria. However, the composition of bacterial phylotypes in three sediments is different...
  58. doi Extremophile culture collection from Andean lakes: extreme pristine environments that host a wide diversity of microorganisms with tolerance to UV radiation
    Omar F Ordoñez
    Planta Piloto de Procesos Industriales Microbiológicos PROIMI, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Av Belgrano y Pasaje Caseros, 4000 Tucuman, Argentina
    Microb Ecol 58:461-73. 2009
    ..Gammaproteobacteria and Cytophaga/Flavobacterium/Bacteroides (CFB) were the most abundant phylogenetic groups with 42% and 18% of identified bands, respectively...
  59. doi Acylhomoserine lactone production and degradation by the fish pathogen Tenacibaculum maritimum, a member of the Cytophaga-Flavobacterium-Bacteroides (CFB) group
    Manuel Romero
    Departamento de Microbiologia, Facultad de Biología CIBUS, Universidad de Santiago de Compostela, Santiago, Spain
    FEMS Microbiol Lett 304:131-9. 2010
    ..maritimum need to be further characterized, this discovery extends the paradigm of AHL-mediated QS signalling beyond the Proteobacteria and reinforces its ecological significance...
  60. ncbi The covalent interaction of C3 with IgG immune complexes
    F Vivanco
    Department of Immunology, Fundacion Jimenez Diaz, Madrid, Spain
    Mol Immunol 36:843-52. 1999
    ..Hence C3b marks Ags definitively, from the earliest contact with the innate immune system until their complete elimination from the host...
  61. ncbi Formation of high affinity C5 convertase of the classical pathway of complement
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75703, USA
    J Biol Chem 278:38476-83. 2003
    ....
  62. ncbi [Bacterial diversity in Guangxi buffalo rumen]
    Li Liu
    College of Life Science and Technology, Guangxi University, Guangxi Key Laboratory of Subtropical Bioresources Conservation and Utilization, Nanning 530005, China
    Wei Sheng Wu Xue Bao 49:251-6. 2009
    ..To analyze the diversity of bacterial community in Guangxi buffalo rumen and to identify the possible cellulolytic bacterial group...
  63. doi 16S rDNA sequence analysis of culturable marine biofilm forming bacteria from a ship's hull
    D Inbakandan
    Centre for Ocean Research, Sathyabama University, Chennai, India
    Biofouling 26:893-9. 2010
    ..IK-MB16 Arthrobacter mysorens), G-Proteobacteria (IK-MB3 Halomonas aquamarina, IK-MB15 Halotalea alkalilenta), CFB group bacteria (IK-MB1 Myroides odoratimimus), and Enterobacteria (IK-MB4 Proteus mirabilis)...
  64. ncbi Culture-dependent and -independent approaches establish the complexity of a PAH-degrading microbial consortium
    Marc Viñas
    Department of Microbiology, University of Barcelona, Diagonal 645, E 08028 Barcelona, Spain
    Can J Microbiol 51:897-909. 2005
    ..were the dominant group, representing 83% of the total, while the Cytophaga-Flexibacter-Bacteroides group (CFB) was 11% and the Ascomycota fungi 6%...
  65. doi A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement
    Margaret A Lindorfer
    Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, VA, USA
    Blood 115:2283-91. 2010
    ..These findings suggest an approach to PNH treatment in which both intravascular and extravascular hemolysis can be inhibited while preserving important immune functions of the classical pathway of complement...
  66. ncbi Bacterial population association with phytoplankton cultured in a bivalve hatchery
    J L Nicolas
    Laboratoire de physiologie des Invertébrés, DRV RA, IFREMER, Brest BP70, 29280, Plouzane, France
    Microb Ecol 48:400-13. 2004
    ..to the alpha-Proteobacteria, beta-Proteobacteria, gamma-Proteobacteria, Cytophaga- Flavobacterium- Bacteroides (CFB) group, Actinobacteria, and Bacillus. Members of the Roseobacter clade and CFB group were the most abundant...
  67. doi Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement
    Nenoo Rawal
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75708, USA
    J Biol Chem 283:7853-63. 2008
    ....
  68. ncbi Site-specific variation in Antarctic marine biofilms established on artificial surfaces
    Nicole S Webster
    Biological Sciences Department, University of Canterbury, Christchurch, New Zealand
    Environ Microbiol 8:1177-90. 2006
    ..of bacterial sequences were affiliated to the Gammaproteobacteria, Cytophaga/Flavobacteria of Bacteroidetes (CFB), Verrucomicrobia and Planctomycetales...
  69. pmc Bacterial Activity at -2 to -20 degrees C in Arctic wintertime sea ice
    Karen Junge
    School of Oceanography, Astrobiology Program, University of Washington, Seattle, Washington 98195 7940, USA
    Appl Environ Microbiol 70:550-7. 2004
    ..in situ hybridization was applied to determine the proportions of Bacteria, Cytophaga-Flavobacteria-Bacteroides (CFB), and Archaea...
  70. pmc Community structures of actively growing bacteria shift along a north-south transect in the western North Pacific
    Akito Taniguchi
    Graduate School of Biosphere Science, Hiroshima University, 1 4 4 Kagamiyama, Higashi Hiroshima, Hiroshima, Japan
    Environ Microbiol 10:1007-17. 2008
    ..5 bands), Betaproteobacteria (1 band), Gammaproteobacteria (4 bands), Cytophaga-Flavobacterium-Bacteroides (CFB) group bacteria (5 bands), Gram-positive bacteria (6 bands), and Cyanobacteria (4 bands)...
  71. doi Seasonal succession and UV sensitivity of marine bacterioplankton at an Antarctic coastal site
    Anouk M T Piquet
    Department of Ocean Ecosystems, Centre for Ecological and Evolutionary Studies, University of Groningen, Haren, The Netherlands
    FEMS Microbiol Ecol 73:68-82. 2010
    ..springtime community composed of three evenly abundant bacterial classes: Cytophaga-Flavobacteria-Bacteroidetes (CFB), Gammaproteobacteria and Alphaproteobacteria...
  72. ncbi The diversity of bacterial communities associated with Atlantic cod Gadus morhua
    Bryan Wilson
    School of Biomolecular and Biomedical Science, University College Dublin, Ardmore House, Dublin 4, Ireland
    Microb Ecol 55:425-34. 2008
    ..a diverse consortium of bacteria were found on fish; gamma-proteobacteria and Cytophaga-Flavobacter-Bacteroides (CFB) species were dominant...
  73. ncbi Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypass
    Jennifer S Li
    Department of Pediatrics, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 147:173-80. 2004
    ..76, P = -.016), and with total (rho -0.56, P =.047) and net (rho -0.85, P =.0016) fluid and blood product administration/kg >24 hours after CPB...
  74. ncbi Transcriptome analysis of Yersinia pestis in human plasma: an approach for discovering bacterial genes involved in septicaemic plague
    Sylvie Chauvaux
    Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris Cedex 15, France
    Microbiology 153:3112-24. 2007
    ..Y. pestis genes involved in 12 iron-acquisition systems and one iron-storage system (bfr, bfd) were specifically induced in human plasma...
  75. ncbi Abnormal developmental patterns of suck and swallow rhythms during feeding in preterm infants with bronchopulmonary dysplasia
    I H Gewolb
    University of Maryland School of Medicine, Department of Pediatrics, Baltimore 21201, USA
    Dev Med Child Neurol 43:454-9. 2001
    Infants with bronchopulmonary dysplasia (BFD) often have difficulty achieving coordinated suckle feeding...
  76. ncbi Members of the Cytophaga-Flavobacterium-Bacteroides phylum as intracellular bacteria of acanthamoebae: proposal of 'Candidatus Amoebophilus asiaticus'
    M Horn
    Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, D 83530 Freising, Germany
    Environ Microbiol 3:440-9. 2001
    ..16S rRNA sequence analysis, this endosymbiont could also be assigned to the Cytophaga-Flavobacterium-Bacteroides (CFB) phylum, but was not closely affiliated to any recognized species within this phylogenetic group (less than 82% 16S ..
  77. ncbi Arsenicosis: review of recent advances
    B D Pimparkar
    Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400012
    J Assoc Physicians India 58:617-24, 629. 2010
    ..pulmonary fibrosis, hepatosplenomegaly resembling NCPF, portal hypertension, peripheral vascular disease and BFD, arteriosclerosis and cancers of lung, urinary bladder, other internal organs and diabetes...
  78. ncbi Detection of serine proteases in extracts of the domestic mite Blomia tropicalis
    Federico Montealegre
    Ponce School of Medicine, Puerto Rico 00732, USA
    Exp Appl Acarol 26:87-100. 2002
    ..In addition, our data demonstrate the potential use of biochemical methods to detect serine proteases for evaluation of mite growth in viitro, or to detect environmental exposures to these enzymes...
  79. pmc The principal site of glycation of human complement factor B
    M A Niemann
    Department of Medicine, University of Alabama, Birmingham 35294
    Biochem J 274:473-80. 1991
    ..Evidence is now presented that glucose is covalently attached to lysine-266 of purified human complement Factor B as a result of glycation...
  80. ncbi Decrease of fibrinolytic activity in human endothelial cells by arsenite
    Shinn Jong Jiang
    Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Thromb Res 105:55-62. 2002
    Blackfoot disease (BFD) is an endemic peripheral vascular occlusive disease that occurred in the southwest coast of Taiwan...
  81. pmc rgf encodes a novel two-component signal transduction system of Streptococcus agalactiae
    Barbara Spellerberg
    Institute of Medical Microbiology and National Reference Center for Streptococci, University Hospital Aachen, D 52057 Aachen, Germany
    Infect Immun 70:2434-40. 2002
    ..peptidase gene scpB were increased in the mutant strain while the transcription of the secreted CAMP factor gene cfb was unaffected by this mutation...
  82. ncbi Isolation and phylogenetic characterization of bacteria capable of inducing differentiation in the green alga Monostroma oxyspermum
    Yoshihide Matsuo
    Marine Biotechnology Institute, Heita, Kamaishi, Iwate, 026 0001, Japan
    Environ Microbiol 5:25-35. 2003
    ..All these strains were located within the Cytophaga-Flavobacterium-Bacteroides (CFB) complex, and most of these strains were clustered in a clade comprising Zobellia uliginosa...
  83. ncbi Use of a screw-syringe injector for cement delivery during kyphoplasty: technical report
    Arun Paul Amar
    Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Neurosurgery 53:380-2; discussion 383. 2003
    ..This kit uses a series of "bone filler device" (BFD) tubes...
  84. ncbi Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid
    Jing Zhang
    Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
    Neurobiol Aging 26:207-27. 2005
    ..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases...
  85. ncbi Methods for measuring agreement: glucose levels in gingival crevice blood
    Hans Peter Müller
    Faculty of Dentistry, Kuwait University, P O Box 24923, 13110, Safat, Kuwait
    Clin Oral Investig 9:65-9. 2005
    ..drawn by two different methods for comparison of blood glucose determination in capillary fingerstick blood (CFB) and gingival crevice blood (GCB)...
  86. ncbi Duplex shuttle PCR for differential diagnosis of budgerigar fledgling disease and psittacine beak and feather disease
    Hirohito Ogawa
    Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, Japan
    Microbiol Immunol 49:227-37. 2005
    Two common viral diseases in psittacine birds including budgerigar fledgling disease (BFD), generally called avian polyomavirus (APV) infection, and psittacine beak and feather disease (PBFD) have similar clinical manifestations ..
  87. ncbi High-speed digital imaging method for ciliary beat frequency measurement
    Svetlana Dimova
    Johnson and Johnson, Pharmaceutical Research and Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium
    J Pharm Pharmacol 57:521-6. 2005
    ..of this study was to develop a high-speed digital imaging system and related software for ciliary beat frequency (CFB) analysis in order to establish an automated and reliable method that is observer independent and faster compared ..
  88. pmc 16S rRNA sequences and differences in bacteria isolated from the Muztag Ata glacier at increasing depths
    Shurong Xiang
    Institute of Tibetan Plateau Research, Chinese Academy of Science, Beijing, People s Republic of China
    Appl Environ Microbiol 71:4619-27. 2005
    ..were clear differences in the depth distribution, with Proteobacteria, HGC/Cytophaga-Flavobacterium-Bacteroides (CFB), Proteobacteria, LGC/CFB/HGC, Cryobacterium psychrophilum, HGC/CFB, Proteobacteria/HGC/CFB, and HGC/CFB being the ..
  89. ncbi Spermatogenic cells distal to the blood-testis barrier in rats lack C3 convertase regulators and may be at risk of complement-mediated injury
    Masashi Mizuno
    Complement Biology Group, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    J Reprod Immunol 69:23-34. 2006
    ....
  90. ncbi Whole-arm translocations between chromosome 1 and acrocentric G chromosomes are associated with a poor prognosis for spermatogenesis: two new cases and review of the literature
    Francois Vialard
    Laboratoire de Cytogenetique, Hopital Saint Antoine, Paris, France
    Fertil Steril 86:1001.e1-5. 2006
    ..To analyze unusual translocations involving a chromosome 1 whole arm and an acrocentric G chromosome p arm found in two men with azoospermia...
  91. ncbi Characterization of the bacterial community associated with the surface and mucus layer of whiting (Merlangius merlangus)
    Cindy J Smith
    School of Biological and Environmental Science, University College Dublin, Dublin, Ireland
    FEMS Microbiol Ecol 62:90-7. 2007
    ..In addition to other Photobacterium phylotypes, members of the CFB and Clostridia groups were also detected...
  92. doi Formability of ABX3 (X = F, Cl, Br, I) halide perovskites
    Chonghea Li
    Shanghai Key Laboratory of Modern Metallurgy and Materials Processingï, Shanghai University, Shanghai 200072, People s Republic of China
    Acta Crystallogr B 64:702-7. 2008
    ..for all 186 complex halides systems, only one system (CsF-MnF2) without perovskite structure and six systems (RbF-PbF2, CsF-BeF2, KCl-FeCl2, TlI-MnI2, RbI-SnI2, TlI-PbI2) with perovskite structure were wrongly classified, so its ..
  93. doi Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study
    A Farwick
    Section of Clinical Epidemiology, Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany
    Eye (Lond) 23:2238-44. 2009
    ..Little is known about the role of genetic variants in the early stages of age-related macular degeneration (AMD). We aimed to investigate how genetic variations within five well-defined genes relate to AMD severity...
  94. doi Bacterial diversity in the rumen of Gayals (Bos frontalis), Swamp buffaloes (Bubalus bubalis) and Holstein cow as revealed by cloned 16S rRNA gene sequences
    Shuli Yang
    Faculty of Animal Science and Technology, Yunnan Agricultural University, 650201, Kunming, China
    Mol Biol Rep 37:2063-73. 2010
    ..retrieved fell into the phyla of low G + C subdivision (329 sequences) and Cytophaga-Flexibacter-Bacteroides (CFB, 123 sequences) with the percentages of 70 and 26.2, respectively...
  95. doi How immune complexes from certain IgG NAbs and any F(ab')₂ can mediate excessive complement activation
    Hans U Lutz
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Adv Exp Med Biol 750:186-96. 2012
    ....
  96. pmc Effects of hydrogen sulfide on bacterial communities on the surface of galatheid crab, Shinkaia crosnieri, and in a bacterial mat cultured in rearing tanks
    Masaaki Konishi
    Japan Agency for Marine Earth Science and Technology, Japan
    Microbes Environ 28:25-32. 2013
    ..Osedax mucofloris endosymbiont-affiliated Epsilonproteobacteria, and Flavobacteria closely related to CFB group bacterial epibiont of Rimicaris exoculata...
  97. doi Analysis of the attached microbial community on mucilaginous cyanobacterial aggregates in the eutrophic Lake Taihu reveals the importance of Planctomycetes
    Hai Yuan Cai
    State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, People s Republic of China
    Microb Ecol 66:73-83. 2013
    ..dominant members of the microbial community were Planctomycetes followed by Cytophaga-Flavobacterium-Bacteroides (CFB), Betaproteobacteria, and Gammaproteobacteria...
  98. doi Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard
    B Jansen van Vuuren
    College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4PB, UK
    J Immunol Methods 402:50-6. 2014
    ..The kinetic-epitope analysis for fB indicates that the capture epitope is on the fB/Bb protein fragment which can then become covered by the formation of C3bBb or C3bBbP complexes during the time course of the cascade. ..
  99. pmc Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?
    Maria Chiara Marinozzi
    Institut National de la Santé et de la Recherche Médicale UMRS 1138, Cordeliers Research Center, Complement and Diseases Team, Paris, France Université Paris Descartes Sorbonne Paris Cité, Paris, France Assistance Publique Hôpitaux de Paris, Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, Paris, France
    J Am Soc Nephrol 25:2053-65. 2014
    ..This study highlights that functional assessment of identified nucleotide changes in FB is mandatory to confirm disease association. ..
  100. pmc Impact of the common genetic associations of age-related macular degeneration upon systemic complement component C3d levels
    Tina Ristau
    Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany
    PLoS ONE 9:e93459. 2014
    ..associations with environmental factors, SNPs and various haplotypes of complement factor H (CFH) genes and complement factor B (CFB) genes were analyzed...

Research Grants39

  1. Baerbel Rohrer; Fiscal Year: 2014
    ..has implicated variations in the complement inhibitory protein factor H (CFH), as well as in the genes for complement factor B (CFB), C2 and C3, as potential risk factors for the disease...
  2. Wei Chao; Fiscal Year: 2015
    ..demonstrated that TLR stimulation in vitro or polymicrobial sepsis in vivo specifically induces a robust complement factor B (cfB) expression in the heart, a key component of alternative pathway...
  3. SIBLING STUDY OF AGE-RELATED MACULAR DEGENERATION
    Margaret M DeAngelis; Fiscal Year: 2010
    ..investigation of the complement pathway has revealed associations between AMD risk and rare alleles in the C2/CFB, C3 and CFH1-5...
  4. 5-HT1A receptor anti-apoptotic transduction pathways in suicide
    Victoria Arango; Fiscal Year: 2013
    ..represents a mechanism to counteract the reduction in the activity of the transduction pathways activated via the Gbg subunit...
  5. MELVIN EDWARD MEDOF; Fiscal Year: 2015
    ..We believe the studies will provide a new window into processes involved in atherothrombosis and that the insights derived from them will identify important therapeutic targets. ..
  6. Margaret A Pericak-Vance; Fiscal Year: 2014
    ..and confirmed variations in multiple genes that strongly affect risk to AMD, including CFH, HTRA1/ARMS2, C2/CFB, and C3 explaining a significant portion of the genetic risk for AMD...
  7. William K Scott; Fiscal Year: 2015
    ..have identified and confirmed variations in multiple genes that affect risk to AMD, including CFH, HTRA1/ARMS2, C2/CFB, and C3 (DeAngelis et al. 2007;Edwards et al. 2005;Haines et al. 2005;Jakobsdottir et al. 2005;Klein et al...
  8. Jeremy B Sokolove; Fiscal Year: 2015
    ..identified target of the anti-citrullinated protein antibody (ACPA) response in RA is citrullinated fibrinogen (cFb)...
  9. Mechanisms of injury and acute repair of axons in TBI
    Ramesh Raghupathi; Fiscal Year: 2012
    ..We have developed and in vitro model of focal axonal injury in primary chick forebrain (CFB) neurons that mimics many features observed in vivo...
  10. Kevin R Regner; Fiscal Year: 2015
    ..AGS3 influences renal epithelial cell number by altering the balance of proliferative and apoptotic pathways in a Gbg- dependent manner...
  11. Songhai Chen; Fiscal Year: 2015
    ..These receptors typically couple to G proteins of the Gi/o class, and mediate their functions through Gbg dimers...
  12. Prevention and Promotion with Youth in Community-Based Afterschool Programs
    Emilie P Smith; Fiscal Year: 2013
    ..Over the past 40 years since its inception, the Good Behavior Game (GBG) has emerged as an effective approach for reducing behavior problems and substance abuse among youth (Baer et al...
  13. NEVIN ALAN LAMBERT; Fiscal Year: 2016
    ..with GPCRs and/or G-protein heterotrimers;and (4) to determine if G-proteins dissociate into component Get and Gbg subunits during signaling...
  14. Nicholas S Ialongo; Fiscal Year: 2014
    ..Teacher-delivered interventions, such as the Good Behavior Game (GBG) and Promoting Alternative Thinking Strategies (PATHS), can improve students'on-task and pro-social classroom ..
  15. Elliott M Ross; Fiscal Year: 2015
    ..G protein modules consist of a conserved group of interacting proteins: receptors, G protein Ga and Gbg subunits, GTPase activating proteins (GAP) and effector proteins...
  16. JOHN E SONDEK; Fiscal Year: 2015
    ..PLC-b isozymes also are directly activated by release of Gbg dimers from heterotrimeric G proteins...
  17. G protein-mediated modulation of synaptic vesicle fusion
    Simon T Alford; Fiscal Year: 2010
    ..b>Gbg binds directly to SNAP-25 incorporated into the SNARE complex of primed vesicles...
  18. ANJA KRISTINA KURKI; Fiscal Year: 2014
    ..The programmatic base for the proposed work is the Good Behavior Game (GBG)...
  19. Prevention Services for Early Drug Abuse Risk: Teachers Implement, Sustain, Adapt
    JEANNE MARIE PODUSKA; Fiscal Year: 2013
    ..The IES-funded trial is a randomized field trial designed to test the Good Behavior Game (GBG), a classroom-based behavior management strategy, under two conditions of professional development and compared to ..
  20. RESTRUCTURING CATALYSIS IN THE MANDELATE PATHWAY
    JOHN GERLT; Fiscal Year: 2000
    ..mandelamide hydrolase (MAH), mandelate racemase (MR), S-mandelate dehydrogenase, benzoylformate decarboxylase (BFD), and two nicotinamide-dependent dehydrogenases...
  21. Structure, Function and Dynamics of Heme Degrading Enzymes
    Mario Rivera; Fiscal Year: 2009
    ..studies are:(1) Biochemical and structural characterization of two previously unknown electron transport proteins (Bfd and Fpr), which we hypothesize function to deliver the 7 electrons needed by heme oxygenase to cleave the heme and ..
  22. SPECIFICITY OF GBg SIGNALING
    Diomedes Logothetis; Fiscal Year: 2004
    ..that the activated G protein splits into its component subunits, the alpha-GTP (Ga-GTP) subunit and the betagamma (Gbg) complex, thus generating two signaling molecules that interact with specific effectors...
  23. MOLECULAR INTERACTIONS AT THE CELL SURFACE
    PAUL SIGLER; Fiscal Year: 2000
    ..analysis of transducin (Gtabg), the heterotrimeric G-protein of the visual system, by visualizing the Gbg subunits, the Gabg assembly and the complexed formed by Ga-GTP with its downstream target,the g-subunit of the cGMP ..
  24. Scaling-up Prevention Services for Early Drug Abuse Risk in School Systems
    Jeanne Poduska; Fiscal Year: 2009
    ..scaling up a fully developed and effective classroom-based behavior management strategy, the Good Behavior Game (GBG)...
  25. RYANODINE RECEPTOR REGULATION
    JOHN SUTKO; Fiscal Year: 2003
    ..In this project the investigator will use the back phosphorylation-fragmentation-derivatization (BFD) and fragmentation Western blot (frag-blot) methods to determine the in vivo phosphorylation stoichiometries of ..
  26. Activation and regulation of the lectin pathway
    Nenoo Rawal; Fiscal Year: 2007
    ..abstract_text> ..
  27. ROD NEURODEGENERATIVE AND PROTECTIVE GENES
    Baerbel Rohrer; Fiscal Year: 2005
    ..We expect to isolate common downstream target genes that are activated both during degeneration and neuroprotection. ..
  28. Transgenic Rod Development and Function
    Baerbel Rohrer; Fiscal Year: 2005
    ..However, more importantly, it will provide avenues for studying gene defects at the single cell level not only in the retina, but in other systems as well. ..
  29. Biological Factors for Age-Related Macular Degeneration
    Johanna Seddon; Fiscal Year: 2004
    ..abstract_text> ..
  30. Biomarkers for Parkinson's Disease (PD) and PD Dementia
    Jing Zhang; Fiscal Year: 2008
    ..abstract_text> ..
  31. Proteomic Studies in Parkinson's Disease
    Jing Zhang; Fiscal Year: 2008
    ....
  32. Factor B and energy coupling in mitochondria
    GRIGORY BELOGRUDOV; Fiscal Year: 2007
    ..The proposed research is expected to advance the knowledge of the molecular mechanisms of energy transfer and conservation in mitochondria, and shed light on the role of mitochondria in a number of human disorders. ..
  33. Increasing HCV Knowledge & Service Use in Drug Tx Pgms
    Shiela Strauss; Fiscal Year: 2007
    ..In its manualized form, successful elements of the training will be disseminated to programs nationwide ..
  34. Prevention Services in Schools for Early Drug Abuse Risk
    Sheppard Kellam; Fiscal Year: 2006
    ..abstract_text> ..
  35. Development and Malleability from Childhood to Adulthood
    Sheppard Kellam; Fiscal Year: 2004
    ..abstract_text> ..
  36. A Follow-up of Classroom Services to Prevent Drug Use
    Jeanne Poduska; Fiscal Year: 2009
    ..The application builds upon current work to maximize efficiency of both costs and time in developing, replicating and extending to system-wide use evidence-based prevention programs. ..
  37. DITHIOCARBAMATE PESTICIDES IN PARKINSON'S DISEASE
    Jing Zhang; Fiscal Year: 2003
    ..The new information will shed more light on the mechanisms by which pesticides interact with aging and genetic vulnerability thereby contributing to development and progression of PD. ..
  38. REDUCING VIOLENCE BY JOINING EDUCATION AND PREVENTION
    Sheppard Kellam; Fiscal Year: 2002
    ..Over the past 16 years, the parents, schools, teachers, and our Board have endorsed random or balanced assignment of children, teachers, and schools in the interest of rigorous evaluation of education and prevention work. ..