Genomes and Genes
Gene Symbol: CFB
Description: complement factor B
Alias: AHUS4, ARMD14, BFD, CFAB, CFBD, FBI12, GBG, H2-Bf, PBF2, complement factor B, B-factor, properdin, C3 proaccelerator, C3 proactivator, C3/C5 convertase, glycine-rich beta-glycoprotein, properdin factor B
Publications304 found, 100 shown here
- Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel diseaseAnn E Ostvik
Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway Department of Gastroenterology and Hepatology, St Olav s University Hospital, Trondheim, Norway Department of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway Department of Pathology and Medical Genetics, St Olav s University Hospital, Trondheim, Norway Research Laboratory, Department of Laboratory Medicine, Nordland Hospital, Bodø, Norway Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway K G Jebsen IRC, University of Oslo, Oslo, Norway and Department of Infectious Diseases, St Olav s University Hospital, Trondheim, Norway
Inflamm Bowel Dis 20:995-1003. 2014..Screening TLR3-agonist response in an intestinal epithelial cell line, we found complement factor B mRNA (CFB) potently upregulated and went on to further study localization of complement factor B synthesis ..
- Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degenerationBert Gold
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
Nat Genet 38:458-62. 2006..These data expand and refine our understanding of the genetic risk for AMD...
- Protective effect of complement factor B and complement component 2 variants in age-related macular degenerationKylee L Spencer
Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
Hum Mol Genet 16:1986-92. 2007..Recently, polymorphisms in the factor B (CFB) and complement component 2 (CC2) genes were associated with decreased susceptibility to AMD...
- Variation in complement factor 3 is associated with risk of age-related macular degenerationJulian B Maller
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nat Genet 39:1200-1. 2007..We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample...
- C3 R102G polymorphism increases risk of age-related macular degenerationKylee L Spencer
Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
Hum Mol Genet 17:1821-4. 2008..Association of variants in the complement factor H (CFH) and complement factor B (CFB) genes has targeted the search for additional loci to the alternative complement cascade, of which C3 ..
- Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathyKelvin Y Lee
Singapore National Eye Centre, Singapore
Invest Ophthalmol Vis Sci 49:2613-9. 2008..Variants in the C2 and BF genes have been found to confer a significantly reduced risk of AMD. This study was undertaken to determine whether these associations occur in Chinese patients with PCV...
- Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variablesJohanna M Seddon
Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts 02111, USA
Invest Ophthalmol Vis Sci 50:2044-53. 2009..The joint effects of genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed...
- Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiologyNaoshi Kondo
Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
Ophthalmology 116:1502-9. 2009..in 4 tightly linked genes of the major histocompatibility complex class III--complement component 2 (C2), complement factor B (CFB), RD RNA-binding protein (RDBP), and superkiller viralicidic activity 2-like (SKIV2L)--are associated ..
- The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degenerationInderjeet Kaur
Hyderabad Eye Research Foundation, Champalimaud Translational Centre, Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India
Invest Ophthalmol Vis Sci 51:59-63. 2010Genes involved in the complement cascade such as complement factor B (CFB) and complement component C2 have been implicated in age-related macular degeneration (AMD) worldwide...
- A novel mutation in the complement factor B gene (CFB) and atypical hemolytic uremic syndromeHanan Tawadrous
Division of Pediatric Nephrology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
Pediatr Nephrol 25:947-51. 2010We report the case of an 8-year-old girl diagnosed with atypical hemolytic uremic syndrome (aHUS) with a complement factor B (CFB) gene mutation. aHUS is a disease of complement dysregulation...
- Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathyLuiz H Lima
The Vitreous, Retina, Macula Consultants of New York and the LuEsther T Mertz Retina Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, USA
Ophthalmology 117:1567-70. 2010..To investigate the frequency of variants in 3 major age-related macular degeneration (AMD)-associated loci in patients of European-American descent with polypoidal choroidal vasculopathy (PCV)...
- Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degenerationWei Chen
Center for Statistical Genetics, Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 107:7401-6. 2010..Our results validate AMD susceptibility loci near CFH (P < 10(-75)), ARMS2 (P < 10(-59)), C2/CFB (P < 10(-20)), C3 (P < 10(-9)), and CFI (P < 10(-6))...
- Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)Benjamin M Neale
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 107:7395-400. 2010..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD...
- Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese populationXiaoqi Liu
Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan, China
Retina 30:1177-84. 2010..Genetic variants, single-nucleotide polymorphisms (SNPs), in these genes were geno-typed for a case-control association study in a mainland Han Chinese population...
- Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese populationIsao Nakata
Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Invest Ophthalmol Vis Sci 53:794-8. 2012To determine whether genetic variants in the complement component 2 and factor B gene (C2/CFB) locus are associated with the risk for typical age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV) in a Japanese ..
- Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3Valentina Cipriani
Institute of Ophthalmology, University College London, London EC1V 9EL, UK
Hum Mol Genet 21:4138-50. 2012..7 × 10(-72)), CFH (complement factor H) (P =2.3 × 10(-47)), C2 (complement component 2)-CFB (complement factor B) (P =5.2 × 10(-9)), C3 (complement component 3) (P =2.2 × 10(-3)) and CFI (P =3...
- Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degenerationKelly M Loyet
Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Invest Ophthalmol Vis Sci 53:6628-37. 2012..To determine if the progression of age-related macular degeneration (AMD) is associated with complement activation in the eye...
- Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican populationBeatriz Buentello-Volante
Department of Genetics and Research Unit, Institute of Ophthalmology Conde de Valenciana Mexico City, Mexico
Mol Vis 18:2518-25. 2012..association of age-related macular degeneration (AMD)-high risk alleles of the complement factor H (CFH), complement factor B (CFB), complement component 2 (C2), complement component 3 (C3), and age-related maculopathy susceptibility ..
- Further assessment of the complement component 2 and factor B region associated with age-related macular degenerationGareth J McKay
Centre for Vision Sciences, Queen s University of Belfast, Belfast, Northern Ireland, United Kingdom
Invest Ophthalmol Vis Sci 50:533-9. 2009..Previous studies have identified polymorphisms in the complement component 2 (CC2) and factor B (CFB) genes, as potential functional variants associated with AMD, in particular CFB R32Q and CC2 rs547154, both of ..
- Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese populationJie Chu
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Chin Med J (Engl) 121:2525-33. 2008..to replicate the associations of representative polymorphisms in three genes (complement factor H (CFH), complement factor B (BF) and HtrA serine peptidase 1 (HTRA1)) with exudative age-related macular degeneration (AMD) in a Han ..
- Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor BTamara Montes
Consejo Superior de Investigaciones Cientificas, Centro de Investigación Biomédica en Red de Enfermedades Raras and Fundación Renal Iñigo Alvarez de Toledo, Ramiro de Maeztu 9, 28040 Madrid, Spain
Proc Natl Acad Sci U S A 106:4366-71. 2009..Knowledge of the functional consequences of polymorphisms in complement activators and regulators will aid disease prediction and inform targeting of diagnostics and therapeutics...
- Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohortGareth J McKay
Centre for Vision and Vascular Sciences, Queen s University of Belfast, Belfast, Northern Ireland BT12 6BA, UK
Mol Vis 16:194-9. 2010..We assess its effect on AMD risk in a Northern Irish sample, test for gene-gene and gene-environment interaction, and review a risk prediction model...
- Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitisMei Chen
Centre for Vision and Vascular Science, Queen s University Belfast, Belfast, UK
Eur J Immunol 40:2870-81. 2010We have shown previously that complement factor H (CFH) and complement factor B (CFB) are constitutively expressed by retinal pigment epithelial cells and their production is regulated by inflammatory cytokines, suggesting that the ..
- aHUS caused by complement dysregulation: new therapies on the horizonAoife M Waters
Department of Nephrology, Great Ormond Street Hospital, London, WC1N 3JH, UK
Pediatr Nephrol 26:41-57. 2011..factor H-related proteins (CFHR), and membrane cofactor protein (MCP)], as well as complement activators [complement factor B (CFB) and C3]...
- Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndromeTara K Maga
Interdepartmental PhD Program in Genetics, Division of Nephrology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Hum Mutat 31:E1445-60. 2010..complement factor H (CFH), complement factor H-related 5 (CFHR5), complement factor I (CFI), CD46 (MCP), complement factor B (CFB), complement component 3 (C3) and thrombomodulin (THBD)...
- The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visitedDon H Anderson
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Prog Retin Eye Res 29:95-112. 2010..genes including: Complement factor H (CFH), complement factor H-related 1 and 3 (CFHR1 and CFHR3), complement factor B (CFB), complement component 2 (C2), and complement component 3 (C3)...
- Characterization of the sheep Complement Factor B gene (CFB)Jinyi Qin
School of Biomedical Sciences, Curtin Health Innovation Research Institute, Western Australian Biomedical Research Institute, Curtin University, GPO Box U1987, Perth, 6845 Western Australia, Australia
Vet Immunol Immunopathol 140:170-4. 2011The Complement Factor B gene (CFB) of the alternative complement pathway has been identified in the sheep Major Histocompatibility Complex (MHC) and its genomic sequence determined...
- Age-related macular degeneration: a perspective on genetic studiesN Patel
Laser and Retinal Research Unit, Kings College Hospital, London, UK
Eye (Lond) 22:768-76. 2008..Age-related macular degeneration (AMD) is a common macular disease in the developed world and recent studies have shown that specific genes may be associated with it and may contribute to a higher risk of developing AMD...
- Application of champedak mannose-binding lectin in the glycoproteomic profiling of serum samples unmasks reduced expression of alpha-2 macroglobulin and complement factor B in patients with nasopharyngeal carcinomaRamarao Seriramalu
Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Electrophoresis 31:2388-95. 2010..Reduced expression of alpha-2 macroglobulin (AMG) and complement factor B (CFB) was detected in sera of patients with nasopharyngeal carcinoma (NPC) when pooled serum samples of the ..
- Lack of association of CFD polymorphisms with advanced age-related macular degenerationJiexi Zeng
Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha, China
Mol Vis 16:2273-8. 2010..Typically, complement factor H (CFH), complement factor B (CFB), complement component 2 (C2), and complement component 3 (C3) are associated with AMD...
- Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjectsKyu Hyung Park
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Mol Vis 15:200-7. 2009..This study was performed to replicate the association between SERPING1 and AMD...
- Recombinant cobra venom factorCarl Wilhelm Vogel
Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
Mol Immunol 41:191-9. 2004....
- Complement regulatory proteins in glomerular diseasesM Nangaku
Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
Kidney Int 54:1419-28. 1998..Systemic administration of soluble recombinant complement regulatory proteins and local overexpression of complement regulatory proteins are promising therapeutic approaches...
- Genetic deficiency of complement factor H in a patient with age-related macular degeneration and membranoproliferative glomerulonephritisTamara Montes
Centro de Investigaciones Biológicas and Centro de Investigación Biomédica en Enfermedades Raras, Ramiro de Maeztu 9, Madrid, Spain
Mol Immunol 45:2897-904. 2008..Genetic analyses of the CFH, CFB, C3, CFHR1-CFHR3 and LOC387715/HTRA1 genes revealed that the patient was heterozygote for a novel missense mutation ..
- The use of signature sequences in different proteins to determine the relative branching order of bacterial divisions: evidence that Fibrobacter diverged at a similar time to Chlamydia and the Cytophaga-Flavobacterium-Bacteroides divisionE Griffiths
Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
Microbiology 147:2611-22. 2001..as well as in homologues from species belonging to the Chlamydia and Cytophaga-Flavobacterium- Bacteroides (CFB) groups, but it is not found in homologues from any other groups of bacteria. The presence of this insert in F...
- Limited selection of sodium channel blocking toxin-producing bacteria from paralytic shellfish toxin-contaminated mussels (Aulacomya ater)Monica Vasquez
Laboratorio de Biotecnologia, INTA Universidad de Chile, Santiago, Chile
Res Microbiol 153:333-8. 2002..types detected clustered with species of the y-Proteobacteria subclass, the Cytophaga-Flexibacter-Bacteroides (CFB), the Fusobacteria and the Firmicutes phyla...
- Isolation, characterization and comparison of bacteria from swine faeces and manure storage pitsMichael A Cotta
Fermentation Biotechnology Research Unit, National Center for Agricultural Utilization Research, USDA, Agricultural Research Service, Peoria, IL 61604, USA
Environ Microbiol 5:737-45. 2003..Isolates similar to Sporomusa and Flexibacter/Cytophaga/Bacteroides (CFB or Bacteroidetes) groups were also obtained...
- Epiphytic bacterial community composition on two common submerged macrophytes in brackish water and freshwaterMelanie Hempel
Limnology, Department of Biology, University of Konstanz, PO Box 659, D 78457 Konstanz, Germany
BMC Microbiol 8:58. 2008..in two habitats, freshwater (Lake Constance) and brackish water (Schaproder Bodden), using fluorescence in situ hybridization. The bacterial community composition was analysed based on habitat, plant species, and plant part...
- Selective modification of rat hepatic microsomal fatty acid chain elongation and desaturation by fibrates: relationship with peroxisome proliferationM Alegret
, Facultad de Farmacia, , Barcelona, Spain
Br J Pharmacol 114:1351-8. 19951. The time-course of the effect of clofibrate (CFB), bezafibrate (BFB) and gemfibrozil (GFB) on lipid plasma levels and palmitoyl-, palmitoleoyl- and gamma-linolenoyl-CoA elongase, delta-9, delta-6 and delta-5 desaturase activities, and ..
- Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibratesM Alegret
, Facultad de Farmacia, , Barcelona, Spain
Br J Pharmacol 112:551-6. 19941. The time-course of the effect of clofibrate (CFB), bezafibrate (BFB) and gemfibrozil (GFB) on lipid plasma levels and palmitoyl-CoA hydrolase and synthetase activities, as well as the correlations with the peroxisomal proliferation ..
- Characterization of the bacterial communities associated with the bald sea urchin disease of the echinoid Paracentrotus lividusPierre T Becker
Laboratoire de Biologie Marine, Universite de Mons Hainaut, 6 Avenue du Champ de Mars, 7000 Mons, Belgium
J Invertebr Pathol 98:136-47. 2008..24 bacterial genomospecies in bald sea urchin lesions: 5 are Alphaproteobacteria, 10 are Gammaproteobacteria, 8 are CFB bacteria and 1 is a Fusobacteria...
- Microbial diversity of a sulfide black smoker in main endeavour hydrothermal vent field, Juan de Fuca RidgeHuaiyang Zhou
Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, P R China
J Microbiol 47:235-47. 2009..Clones of Proteobacteria (gamma-, delta-, beta-), Cytophaga-Flavobacterium-Bacteroides (CFB) and Deinococcus-Thermus occurred as well...
- Endophytic bacterial diversity in rice (Oryza sativa L.) roots estimated by 16S rDNA sequence analysisLei Sun
College of Life Sciences, Capital Normal University, Beijing 100037, People s Republic of China
Microb Ecol 55:415-24. 2008..of alpha, beta, gamma, delta, and epsilon subclasses of the Proteobacteria, Cytophaga/Flexibacter/Bacteroides (CFB) phylum, low G+C gram-positive bacteria, Deinococcus-Thermus, Acidobacteria, and archaea...
- Localized complement activation in the development of protective immunity against Ostertagia ostertagi infections in cattleRobert W Li
Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, United States Department of Agriculture, Beltsville, MD 20705, USA
Vet Parasitol 174:247-56. 2010..Increased mRNA levels of complement components C3, factor B (CFB) and factor I (CFI) in the abomasal mucosa of the infected cattle were confirmed using quantitative PCR while ..
- Poles apart: biodiversity and biogeography of sea ice bacteriaJ T Staley
Department of Microbiology 357242, University of Washington, Seattle 98195, USA
Annu Rev Microbiol 53:189-215. 1999..bacteria fall into four major phylogenetic groups: the proteobacteria, the Cytophaga-Flavobacterium-Bacteroides (CFB) group, and the high and low mol percent gram-positive bacteria...
- [Bacterial diversity of disused thermal vents in Tibetan Yangbajing Region]Bin Chen
Tibetan Plateau Institute of Biology, Lhasa 850001, China
Wei Sheng Wu Xue Bao 49:217-26. 2009..To study the bacterial diversity in sediment and water from two disused thermal vents in Yangbajing, Tibet, China...
- Prevalence of Cardinium bacteria in planthoppers and spider mites and taxonomic revision of "Candidatus Cardinium hertigii" based on detection of a new Cardinium group from biting midgesYuki Nakamura
National Institute of Agrobiological Sciences, Owashi, Tsukuba, Ibaraki 305 8634, Japan
Appl Environ Microbiol 75:6757-63. 2009Cardinium bacteria, members of the phylum Cytophaga-Flavobacterium-Bacteroides (CFB), are intracellular bacteria in arthropods that are capable of inducing reproductive abnormalities in their hosts, which include parasitic wasps, mites, ..
- Biochemical and chemical characterization of trifluoromethylglyoxal bis(guanylhydrazone), a close analog of the antileukemic drug mitoguazoneH Elo
Department of Chemistry, University of Helsinki, Finland
Z Naturforsch C 43:601-5. 1988..of bis(guanylhydrazone) type polyamine antimetabolites, trifluoromethylglyoxal bis(guanylhydrazone) (CF3-GBG), a close analog of the antileukemic drug methylglyoxal bis(guanylhydrazone) (mitoguazone, MGBG) was synthesized ..
- The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularizationBarbel Rohrer
Department of Ophthalmology, Medical University of South Carolina, Charleston, SC 29425, United States
Mol Immunol 48:e1-8. 2011..Proteins encoded by the AMD risk genes participate in the AP (CFB), CP/LP (C2), or in the AP and final common pathway (C3)...
- Bacterial population structure of the jute-retting environmentTulika K Munshi
Department of Microbiology and Biotechnology Center, Faculty of Science, M S University of Baroda, Baroda, Gujarat, 390002, India
Microb Ecol 56:270-82. 2008..of clones from the divisions-Firmicutes ( approximately 11, 12%), Cytophaga-Flexibacter-Bacteroidetes group (CFB; approximately 9, 7%), Verrucomicrobia ( approximately 6, 5%), Acidobacteria ( approximately 4, 5%), Chlorobiales ( ..
- A mitochondrial-like aconitase in the bacterium Bacteroides fragilis: implications for the evolution of the mitochondrial Krebs cycleAnthony D Baughn
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 99:4662-7. 2002..fragilis aconitase is most closely related to aconitases of two other Cytophaga-Flavobacterium-Bacteroides (CFB) group bacteria, Cytophaga hutchinsonii and Fibrobacter succinogenes...
- Planktonic bacteria and fungi are selectively eliminated by exposure to marine macroalgae in close proximityCindy Lam
Institute for Chemistry and Biology of the Marine Environment, University of Oldenburg, Oldenburg, Germany
FEMS Microbiol Ecol 63:283-91. 2008..and fungi was analyzed with selective oligonucleotide probes targeting the Cytophaga/Flavobacterium/Bacteroides (CFB), Alphaproteobacteria and Roseobacter group and the ITS1 region of marine fungi...
- Benzoylformate decarboxylase from Pseudomonas putida as stable catalyst for the synthesis of chiral 2-hydroxy ketonesH Iding
, , , Germany
Chemistry 6:1483-95. 2000The thiamin diphosphate- and Mg2+-dependent enzyme benzoylformate decarboxylase (BFD) from Pseudomonas putida was characterized with respect to its suitability to catalyze the formation of chiral 2-hydroxy ketones in a benzoin-..
- Microbial community variation and functions to excess sludge reduction in a novel gravel contact oxidation reactorShanshan Lin
School of Urban and Environmental Science, Northeast Normal University, Changchun, China
J Hazard Mater 165:1083-90. 2009..those related to the beta-Proteobacteria group, then gamma-Proteobacteria and to Cytophaga-Flexibacter-Bacteriode (CFB)...
- Eliminating complement factor D reduces photoreceptor susceptibility to light-induced damageBarbel Rohrer
Department of Neurosciences Division of Research, Medical University of South Carolina, Charleston, SC 29425, USA
Invest Ophthalmol Vis Sci 48:5282-9. 2007Genetic risk factors such as variations in complement factors H (CFH) and B (CFB) have been implicated in the etiology of age-related macular degeneration...
- Isolation, phylogenetic analysis and screening of marine mollusc-associated bacteria for antimicrobial, hemolytic and surface activitiesLyudmila A Romanenko
Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Prospect 100 let Vladivostoku, 159, Russian Federation
Microbiol Res 163:633-44. 2008..and Alphaproteobacteria, and Less with Firmicutes, Actinobacteria, and Cytophaga-Flavobacterium-Bacteroides (CFB) group...
- [Phylogenetic analysis of bacterial diversity in Pacific Arctic sediments]Hui Rong Li
SOA Key Laboratory for Polar Science, Polar Research Institute of China, Shanghai 200136, China
Wei Sheng Wu Xue Bao 46:177-83. 2006..domain Bacteria: alpha- beta-, gamma-, delta-, epsilon- Proteobacteria, the Cytophaga-Flavobacterium-Bacteroides (CFB) group and Actinobacteria. However, the composition of bacterial phylotypes in three sediments is different...
- Extremophile culture collection from Andean lakes: extreme pristine environments that host a wide diversity of microorganisms with tolerance to UV radiationOmar F Ordoñez
Planta Piloto de Procesos Industriales Microbiológicos PROIMI, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Av Belgrano y Pasaje Caseros, 4000 Tucuman, Argentina
Microb Ecol 58:461-73. 2009..Gammaproteobacteria and Cytophaga/Flavobacterium/Bacteroides (CFB) were the most abundant phylogenetic groups with 42% and 18% of identified bands, respectively...
- Acylhomoserine lactone production and degradation by the fish pathogen Tenacibaculum maritimum, a member of the Cytophaga-Flavobacterium-Bacteroides (CFB) groupManuel Romero
Departamento de Microbiologia, Facultad de Biología CIBUS, Universidad de Santiago de Compostela, Santiago, Spain
FEMS Microbiol Lett 304:131-9. 2010..maritimum need to be further characterized, this discovery extends the paradigm of AHL-mediated QS signalling beyond the Proteobacteria and reinforces its ecological significance...
- The covalent interaction of C3 with IgG immune complexesF Vivanco
Department of Immunology, Fundacion Jimenez Diaz, Madrid, Spain
Mol Immunol 36:843-52. 1999..Hence C3b marks Ags definitively, from the earliest contact with the innate immune system until their complete elimination from the host...
- Formation of high affinity C5 convertase of the classical pathway of complementNenoo Rawal
Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75703, USA
J Biol Chem 278:38476-83. 2003....
- [Bacterial diversity in Guangxi buffalo rumen]Li Liu
College of Life Science and Technology, Guangxi University, Guangxi Key Laboratory of Subtropical Bioresources Conservation and Utilization, Nanning 530005, China
Wei Sheng Wu Xue Bao 49:251-6. 2009..To analyze the diversity of bacterial community in Guangxi buffalo rumen and to identify the possible cellulolytic bacterial group...
- 16S rDNA sequence analysis of culturable marine biofilm forming bacteria from a ship's hullD Inbakandan
Centre for Ocean Research, Sathyabama University, Chennai, India
Biofouling 26:893-9. 2010..IK-MB16 Arthrobacter mysorens), G-Proteobacteria (IK-MB3 Halomonas aquamarina, IK-MB15 Halotalea alkalilenta), CFB group bacteria (IK-MB1 Myroides odoratimimus), and Enterobacteria (IK-MB4 Proteus mirabilis)...
- Culture-dependent and -independent approaches establish the complexity of a PAH-degrading microbial consortiumMarc Viñas
Department of Microbiology, University of Barcelona, Diagonal 645, E 08028 Barcelona, Spain
Can J Microbiol 51:897-909. 2005..were the dominant group, representing 83% of the total, while the Cytophaga-Flexibacter-Bacteroides group (CFB) was 11% and the Ascomycota fungi 6%...
- A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complementMargaret A Lindorfer
Department of Biochemistry and Molecular Genetics, University of Virginia Health Sciences Center, Charlottesville, VA, USA
Blood 115:2283-91. 2010..These findings suggest an approach to PNH treatment in which both intravascular and extravascular hemolysis can be inhibited while preserving important immune functions of the classical pathway of complement...
- Bacterial population association with phytoplankton cultured in a bivalve hatcheryJ L Nicolas
Laboratoire de physiologie des Invertébrés, DRV RA, IFREMER, Brest BP70, 29280, Plouzane, France
Microb Ecol 48:400-13. 2004..to the alpha-Proteobacteria, beta-Proteobacteria, gamma-Proteobacteria, Cytophaga- Flavobacterium- Bacteroides (CFB) group, Actinobacteria, and Bacillus. Members of the Roseobacter clade and CFB group were the most abundant...
- Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complementNenoo Rawal
Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75708, USA
J Biol Chem 283:7853-63. 2008....
- Site-specific variation in Antarctic marine biofilms established on artificial surfacesNicole S Webster
Biological Sciences Department, University of Canterbury, Christchurch, New Zealand
Environ Microbiol 8:1177-90. 2006..of bacterial sequences were affiliated to the Gammaproteobacteria, Cytophaga/Flavobacteria of Bacteroidetes (CFB), Verrucomicrobia and Planctomycetales...
- Bacterial Activity at -2 to -20 degrees C in Arctic wintertime sea iceKaren Junge
School of Oceanography, Astrobiology Program, University of Washington, Seattle, Washington 98195 7940, USA
Appl Environ Microbiol 70:550-7. 2004..in situ hybridization was applied to determine the proportions of Bacteria, Cytophaga-Flavobacteria-Bacteroides (CFB), and Archaea...
- Community structures of actively growing bacteria shift along a north-south transect in the western North PacificAkito Taniguchi
Graduate School of Biosphere Science, Hiroshima University, 1 4 4 Kagamiyama, Higashi Hiroshima, Hiroshima, Japan
Environ Microbiol 10:1007-17. 2008..5 bands), Betaproteobacteria (1 band), Gammaproteobacteria (4 bands), Cytophaga-Flavobacterium-Bacteroides (CFB) group bacteria (5 bands), Gram-positive bacteria (6 bands), and Cyanobacteria (4 bands)...
- Seasonal succession and UV sensitivity of marine bacterioplankton at an Antarctic coastal siteAnouk M T Piquet
Department of Ocean Ecosystems, Centre for Ecological and Evolutionary Studies, University of Groningen, Haren, The Netherlands
FEMS Microbiol Ecol 73:68-82. 2010..springtime community composed of three evenly abundant bacterial classes: Cytophaga-Flavobacteria-Bacteroidetes (CFB), Gammaproteobacteria and Alphaproteobacteria...
- The diversity of bacterial communities associated with Atlantic cod Gadus morhuaBryan Wilson
School of Biomolecular and Biomedical Science, University College Dublin, Ardmore House, Dublin 4, Ireland
Microb Ecol 55:425-34. 2008..a diverse consortium of bacteria were found on fish; gamma-proteobacteria and Cytophaga-Flavobacter-Bacteroides (CFB) species were dominant...
- Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypassJennifer S Li
Department of Pediatrics, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
Am Heart J 147:173-80. 2004..76, P = -.016), and with total (rho -0.56, P =.047) and net (rho -0.85, P =.0016) fluid and blood product administration/kg >24 hours after CPB...
- Transcriptome analysis of Yersinia pestis in human plasma: an approach for discovering bacterial genes involved in septicaemic plagueSylvie Chauvaux
Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris Cedex 15, France
Microbiology 153:3112-24. 2007..Y. pestis genes involved in 12 iron-acquisition systems and one iron-storage system (bfr, bfd) were specifically induced in human plasma...
- Abnormal developmental patterns of suck and swallow rhythms during feeding in preterm infants with bronchopulmonary dysplasiaI H Gewolb
University of Maryland School of Medicine, Department of Pediatrics, Baltimore 21201, USA
Dev Med Child Neurol 43:454-9. 2001Infants with bronchopulmonary dysplasia (BFD) often have difficulty achieving coordinated suckle feeding...
- Members of the Cytophaga-Flavobacterium-Bacteroides phylum as intracellular bacteria of acanthamoebae: proposal of 'Candidatus Amoebophilus asiaticus'M Horn
Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, D 83530 Freising, Germany
Environ Microbiol 3:440-9. 2001..16S rRNA sequence analysis, this endosymbiont could also be assigned to the Cytophaga-Flavobacterium-Bacteroides (CFB) phylum, but was not closely affiliated to any recognized species within this phylogenetic group (less than 82% 16S ..
- Arsenicosis: review of recent advancesB D Pimparkar
Department of Gastroenterology, Seth GS Medical College and KEM Hospital, Parel, Mumbai 400012
J Assoc Physicians India 58:617-24, 629. 2010..pulmonary fibrosis, hepatosplenomegaly resembling NCPF, portal hypertension, peripheral vascular disease and BFD, arteriosclerosis and cancers of lung, urinary bladder, other internal organs and diabetes...
- Detection of serine proteases in extracts of the domestic mite Blomia tropicalisFederico Montealegre
Ponce School of Medicine, Puerto Rico 00732, USA
Exp Appl Acarol 26:87-100. 2002..In addition, our data demonstrate the potential use of biochemical methods to detect serine proteases for evaluation of mite growth in viitro, or to detect environmental exposures to these enzymes...
- The principal site of glycation of human complement factor BM A Niemann
Department of Medicine, University of Alabama, Birmingham 35294
Biochem J 274:473-80. 1991..Evidence is now presented that glucose is covalently attached to lysine-266 of purified human complement Factor B as a result of glycation...
- Decrease of fibrinolytic activity in human endothelial cells by arseniteShinn Jong Jiang
Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Thromb Res 105:55-62. 2002Blackfoot disease (BFD) is an endemic peripheral vascular occlusive disease that occurred in the southwest coast of Taiwan...
- rgf encodes a novel two-component signal transduction system of Streptococcus agalactiaeBarbara Spellerberg
Institute of Medical Microbiology and National Reference Center for Streptococci, University Hospital Aachen, D 52057 Aachen, Germany
Infect Immun 70:2434-40. 2002..peptidase gene scpB were increased in the mutant strain while the transcription of the secreted CAMP factor gene cfb was unaffected by this mutation...
- Isolation and phylogenetic characterization of bacteria capable of inducing differentiation in the green alga Monostroma oxyspermumYoshihide Matsuo
Marine Biotechnology Institute, Heita, Kamaishi, Iwate, 026 0001, Japan
Environ Microbiol 5:25-35. 2003..All these strains were located within the Cytophaga-Flavobacterium-Bacteroides (CFB) complex, and most of these strains were clustered in a clade comprising Zobellia uliginosa...
- Use of a screw-syringe injector for cement delivery during kyphoplasty: technical reportArun Paul Amar
Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Neurosurgery 53:380-2; discussion 383. 2003..This kit uses a series of "bone filler device" (BFD) tubes...
- Quantitative proteomic analysis of age-related changes in human cerebrospinal fluidJing Zhang
Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
Neurobiol Aging 26:207-27. 2005..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases...
- Methods for measuring agreement: glucose levels in gingival crevice bloodHans Peter Müller
Faculty of Dentistry, Kuwait University, P O Box 24923, 13110, Safat, Kuwait
Clin Oral Investig 9:65-9. 2005..drawn by two different methods for comparison of blood glucose determination in capillary fingerstick blood (CFB) and gingival crevice blood (GCB)...
- Duplex shuttle PCR for differential diagnosis of budgerigar fledgling disease and psittacine beak and feather diseaseHirohito Ogawa
Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, Japan
Microbiol Immunol 49:227-37. 2005Two common viral diseases in psittacine birds including budgerigar fledgling disease (BFD), generally called avian polyomavirus (APV) infection, and psittacine beak and feather disease (PBFD) have similar clinical manifestations ..
- High-speed digital imaging method for ciliary beat frequency measurementSvetlana Dimova
Johnson and Johnson, Pharmaceutical Research and Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium
J Pharm Pharmacol 57:521-6. 2005..of this study was to develop a high-speed digital imaging system and related software for ciliary beat frequency (CFB) analysis in order to establish an automated and reliable method that is observer independent and faster compared ..
- 16S rRNA sequences and differences in bacteria isolated from the Muztag Ata glacier at increasing depthsShurong Xiang
Institute of Tibetan Plateau Research, Chinese Academy of Science, Beijing, People s Republic of China
Appl Environ Microbiol 71:4619-27. 2005..were clear differences in the depth distribution, with Proteobacteria, HGC/Cytophaga-Flavobacterium-Bacteroides (CFB), Proteobacteria, LGC/CFB/HGC, Cryobacterium psychrophilum, HGC/CFB, Proteobacteria/HGC/CFB, and HGC/CFB being the ..
- Spermatogenic cells distal to the blood-testis barrier in rats lack C3 convertase regulators and may be at risk of complement-mediated injuryMasashi Mizuno
Complement Biology Group, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
J Reprod Immunol 69:23-34. 2006....
- Whole-arm translocations between chromosome 1 and acrocentric G chromosomes are associated with a poor prognosis for spermatogenesis: two new cases and review of the literatureFrancois Vialard
Laboratoire de Cytogenetique, Hopital Saint Antoine, Paris, France
Fertil Steril 86:1001.e1-5. 2006..To analyze unusual translocations involving a chromosome 1 whole arm and an acrocentric G chromosome p arm found in two men with azoospermia...
- Characterization of the bacterial community associated with the surface and mucus layer of whiting (Merlangius merlangus)Cindy J Smith
School of Biological and Environmental Science, University College Dublin, Dublin, Ireland
FEMS Microbiol Ecol 62:90-7. 2007..In addition to other Photobacterium phylotypes, members of the CFB and Clostridia groups were also detected...
- Formability of ABX3 (X = F, Cl, Br, I) halide perovskitesChonghea Li
Shanghai Key Laboratory of Modern Metallurgy and Materials Processingï, Shanghai University, Shanghai 200072, People s Republic of China
Acta Crystallogr B 64:702-7. 2008..for all 186 complex halides systems, only one system (CsF-MnF2) without perovskite structure and six systems (RbF-PbF2, CsF-BeF2, KCl-FeCl2, TlI-MnI2, RbI-SnI2, TlI-PbI2) with perovskite structure were wrongly classified, so its ..
- Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina studyA Farwick
Section of Clinical Epidemiology, Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany
Eye (Lond) 23:2238-44. 2009..Little is known about the role of genetic variants in the early stages of age-related macular degeneration (AMD). We aimed to investigate how genetic variations within five well-defined genes relate to AMD severity...
- Bacterial diversity in the rumen of Gayals (Bos frontalis), Swamp buffaloes (Bubalus bubalis) and Holstein cow as revealed by cloned 16S rRNA gene sequencesShuli Yang
Faculty of Animal Science and Technology, Yunnan Agricultural University, 650201, Kunming, China
Mol Biol Rep 37:2063-73. 2010..retrieved fell into the phyla of low G + C subdivision (329 sequences) and Cytophaga-Flexibacter-Bacteroides (CFB, 123 sequences) with the percentages of 70 and 26.2, respectively...
- How immune complexes from certain IgG NAbs and any F(ab')₂ can mediate excessive complement activationHans U Lutz
Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
Adv Exp Med Biol 750:186-96. 2012....
- Effects of hydrogen sulfide on bacterial communities on the surface of galatheid crab, Shinkaia crosnieri, and in a bacterial mat cultured in rearing tanksMasaaki Konishi
Japan Agency for Marine Earth Science and Technology, Japan
Microbes Environ 28:25-32. 2013..Osedax mucofloris endosymbiont-affiliated Epsilonproteobacteria, and Flavobacteria closely related to CFB group bacterial epibiont of Rimicaris exoculata...
- Analysis of the attached microbial community on mucilaginous cyanobacterial aggregates in the eutrophic Lake Taihu reveals the importance of PlanctomycetesHai Yuan Cai
State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, People s Republic of China
Microb Ecol 66:73-83. 2013..dominant members of the microbial community were Planctomycetes followed by Cytophaga-Flavobacterium-Bacteroides (CFB), Betaproteobacteria, and Gammaproteobacteria...
- Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standardB Jansen van Vuuren
College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4PB, UK
J Immunol Methods 402:50-6. 2014..The kinetic-epitope analysis for fB indicates that the capture epitope is on the fB/Bb protein fragment which can then become covered by the formation of C3bBb or C3bBbP complexes during the time course of the cascade. ..
- Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?Maria Chiara Marinozzi
Institut National de la Santé et de la Recherche Médicale UMRS 1138, Cordeliers Research Center, Complement and Diseases Team, Paris, France Université Paris Descartes Sorbonne Paris Cité, Paris, France Assistance Publique Hôpitaux de Paris, Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, Paris, France
J Am Soc Nephrol 25:2053-65. 2014..This study highlights that functional assessment of identified nucleotide changes in FB is mandatory to confirm disease association. ..
- Impact of the common genetic associations of age-related macular degeneration upon systemic complement component C3d levelsTina Ristau
Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany
PLoS ONE 9:e93459. 2014..associations with environmental factors, SNPs and various haplotypes of complement factor H (CFH) genes and complement factor B (CFB) genes were analyzed...
- Baerbel Rohrer; Fiscal Year: 2014..has implicated variations in the complement inhibitory protein factor H (CFH), as well as in the genes for complement factor B (CFB), C2 and C3, as potential risk factors for the disease...
- Wei Chao; Fiscal Year: 2015..demonstrated that TLR stimulation in vitro or polymicrobial sepsis in vivo specifically induces a robust complement factor B (cfB) expression in the heart, a key component of alternative pathway...
- SIBLING STUDY OF AGE-RELATED MACULAR DEGENERATIONMargaret M DeAngelis; Fiscal Year: 2010..investigation of the complement pathway has revealed associations between AMD risk and rare alleles in the C2/CFB, C3 and CFH1-5...
- 5-HT1A receptor anti-apoptotic transduction pathways in suicideVictoria Arango; Fiscal Year: 2013..represents a mechanism to counteract the reduction in the activity of the transduction pathways activated via the Gbg subunit...
- MELVIN EDWARD MEDOF; Fiscal Year: 2015..We believe the studies will provide a new window into processes involved in atherothrombosis and that the insights derived from them will identify important therapeutic targets. ..
- Margaret A Pericak-Vance; Fiscal Year: 2014..and confirmed variations in multiple genes that strongly affect risk to AMD, including CFH, HTRA1/ARMS2, C2/CFB, and C3 explaining a significant portion of the genetic risk for AMD...
- William K Scott; Fiscal Year: 2015..have identified and confirmed variations in multiple genes that affect risk to AMD, including CFH, HTRA1/ARMS2, C2/CFB, and C3 (DeAngelis et al. 2007;Edwards et al. 2005;Haines et al. 2005;Jakobsdottir et al. 2005;Klein et al...
- Jeremy B Sokolove; Fiscal Year: 2015..identified target of the anti-citrullinated protein antibody (ACPA) response in RA is citrullinated fibrinogen (cFb)...
- Mechanisms of injury and acute repair of axons in TBIRamesh Raghupathi; Fiscal Year: 2012..We have developed and in vitro model of focal axonal injury in primary chick forebrain (CFB) neurons that mimics many features observed in vivo...
- Kevin R Regner; Fiscal Year: 2015..AGS3 influences renal epithelial cell number by altering the balance of proliferative and apoptotic pathways in a Gbg- dependent manner...
- Songhai Chen; Fiscal Year: 2015..These receptors typically couple to G proteins of the Gi/o class, and mediate their functions through Gbg dimers...
- Prevention and Promotion with Youth in Community-Based Afterschool ProgramsEmilie P Smith; Fiscal Year: 2013..Over the past 40 years since its inception, the Good Behavior Game (GBG) has emerged as an effective approach for reducing behavior problems and substance abuse among youth (Baer et al...
- NEVIN ALAN LAMBERT; Fiscal Year: 2016..with GPCRs and/or G-protein heterotrimers;and (4) to determine if G-proteins dissociate into component Get and Gbg subunits during signaling...
- Nicholas S Ialongo; Fiscal Year: 2014..Teacher-delivered interventions, such as the Good Behavior Game (GBG) and Promoting Alternative Thinking Strategies (PATHS), can improve students'on-task and pro-social classroom ..
- Elliott M Ross; Fiscal Year: 2015..G protein modules consist of a conserved group of interacting proteins: receptors, G protein Ga and Gbg subunits, GTPase activating proteins (GAP) and effector proteins...
- JOHN E SONDEK; Fiscal Year: 2015..PLC-b isozymes also are directly activated by release of Gbg dimers from heterotrimeric G proteins...
- G protein-mediated modulation of synaptic vesicle fusionSimon T Alford; Fiscal Year: 2010..b>Gbg binds directly to SNAP-25 incorporated into the SNARE complex of primed vesicles...
- ANJA KRISTINA KURKI; Fiscal Year: 2014..The programmatic base for the proposed work is the Good Behavior Game (GBG)...
- Prevention Services for Early Drug Abuse Risk: Teachers Implement, Sustain, AdaptJEANNE MARIE PODUSKA; Fiscal Year: 2013..The IES-funded trial is a randomized field trial designed to test the Good Behavior Game (GBG), a classroom-based behavior management strategy, under two conditions of professional development and compared to ..
- RESTRUCTURING CATALYSIS IN THE MANDELATE PATHWAYJOHN GERLT; Fiscal Year: 2000..mandelamide hydrolase (MAH), mandelate racemase (MR), S-mandelate dehydrogenase, benzoylformate decarboxylase (BFD), and two nicotinamide-dependent dehydrogenases...
- Structure, Function and Dynamics of Heme Degrading EnzymesMario Rivera; Fiscal Year: 2009..studies are:(1) Biochemical and structural characterization of two previously unknown electron transport proteins (Bfd and Fpr), which we hypothesize function to deliver the 7 electrons needed by heme oxygenase to cleave the heme and ..
- SPECIFICITY OF GBg SIGNALINGDiomedes Logothetis; Fiscal Year: 2004..that the activated G protein splits into its component subunits, the alpha-GTP (Ga-GTP) subunit and the betagamma (Gbg) complex, thus generating two signaling molecules that interact with specific effectors...
- MOLECULAR INTERACTIONS AT THE CELL SURFACEPAUL SIGLER; Fiscal Year: 2000..analysis of transducin (Gtabg), the heterotrimeric G-protein of the visual system, by visualizing the Gbg subunits, the Gabg assembly and the complexed formed by Ga-GTP with its downstream target,the g-subunit of the cGMP ..
- Scaling-up Prevention Services for Early Drug Abuse Risk in School SystemsJeanne Poduska; Fiscal Year: 2009..scaling up a fully developed and effective classroom-based behavior management strategy, the Good Behavior Game (GBG)...
- RYANODINE RECEPTOR REGULATIONJOHN SUTKO; Fiscal Year: 2003..In this project the investigator will use the back phosphorylation-fragmentation-derivatization (BFD) and fragmentation Western blot (frag-blot) methods to determine the in vivo phosphorylation stoichiometries of ..
- Activation and regulation of the lectin pathwayNenoo Rawal; Fiscal Year: 2007..abstract_text> ..
- ROD NEURODEGENERATIVE AND PROTECTIVE GENESBaerbel Rohrer; Fiscal Year: 2005..We expect to isolate common downstream target genes that are activated both during degeneration and neuroprotection. ..
- Transgenic Rod Development and FunctionBaerbel Rohrer; Fiscal Year: 2005..However, more importantly, it will provide avenues for studying gene defects at the single cell level not only in the retina, but in other systems as well. ..
- Biological Factors for Age-Related Macular DegenerationJohanna Seddon; Fiscal Year: 2004..abstract_text> ..
- Biomarkers for Parkinson's Disease (PD) and PD DementiaJing Zhang; Fiscal Year: 2008..abstract_text> ..
- Proteomic Studies in Parkinson's DiseaseJing Zhang; Fiscal Year: 2008....
- Factor B and energy coupling in mitochondriaGRIGORY BELOGRUDOV; Fiscal Year: 2007..The proposed research is expected to advance the knowledge of the molecular mechanisms of energy transfer and conservation in mitochondria, and shed light on the role of mitochondria in a number of human disorders. ..
- Increasing HCV Knowledge & Service Use in Drug Tx PgmsShiela Strauss; Fiscal Year: 2007..In its manualized form, successful elements of the training will be disseminated to programs nationwide ..
- Prevention Services in Schools for Early Drug Abuse RiskSheppard Kellam; Fiscal Year: 2006..abstract_text> ..
- Development and Malleability from Childhood to AdulthoodSheppard Kellam; Fiscal Year: 2004..abstract_text> ..
- A Follow-up of Classroom Services to Prevent Drug UseJeanne Poduska; Fiscal Year: 2009..The application builds upon current work to maximize efficiency of both costs and time in developing, replicating and extending to system-wide use evidence-based prevention programs. ..
- DITHIOCARBAMATE PESTICIDES IN PARKINSON'S DISEASEJing Zhang; Fiscal Year: 2003..The new information will shed more light on the mechanisms by which pesticides interact with aging and genetic vulnerability thereby contributing to development and progression of PD. ..
- REDUCING VIOLENCE BY JOINING EDUCATION AND PREVENTIONSheppard Kellam; Fiscal Year: 2002..Over the past 16 years, the parents, schools, teachers, and our Board have endorsed random or balanced assignment of children, teachers, and schools in the interest of rigorous evaluation of education and prevention work. ..