CENPW

Summary

Gene Symbol: CENPW
Description: centromere protein W
Alias: C6orf173, CENP-W, CUG2, centromere protein W, cancer-up-regulated gene 2 protein, cancer-upregulated gene 2
Species: human

Top Publications

  1. doi CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Cell 135:1039-52. 2008
  2. doi Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function
    Hyejin Kim
    Department of Microbiology, Chungnam National University, Daejeon 305 764, Korea
    Mol Cells 27:697-701. 2009
  3. pmc Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state
    Lisa Prendergast
    Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Ireland
    PLoS Biol 9:e1001082. 2011
  4. pmc Centromere Protein (CENP)-W Interacts with Heterogeneous Nuclear Ribonucleoprotein (hnRNP) U and May Contribute to Kinetochore-Microtubule Attachment in Mitotic Cells
    Younghwa Chun
    Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, Daejeon, Republic of Korea
    PLoS ONE 11:e0149127. 2016
  5. doi A new kinetochore component CENP-W interacts with the polycomb-group protein EZH2 to promote gene silencing
    Wansoo Koh
    Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, Daejeon 305 764, Republic of Korea
    Biochem Biophys Res Commun 464:256-62. 2015
  6. pmc CENP-W plays a role in maintaining bipolar spindle structure
    Agnieszka Kaczmarczyk
    Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Ireland
    PLoS ONE 9:e106464. 2014
  7. pmc A novel common variant in DCST2 is associated with length in early life and height in adulthood
    Ralf J P van der Valk
    Department of Epidemiology, Department of Paediatrics, The Generation R Study Group
    Hum Mol Genet 24:1155-68. 2015
  8. pmc Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment
    John P Kemp
    MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
    PLoS Genet 10:e1004423. 2014
  9. doi Suppression of autophagic genes sensitizes CUG2-overexpressing A549 human lung cancer cells to oncolytic vesicular stomatitis virus-induced apoptosis
    Waraporn Malilas
    BK21, Department of Cogno Mechatronics Engineering, Pusan National University, Busan 609 735, Republic of Korea
    Int J Oncol 44:1177-84. 2014
  10. doi Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation
    Waraporn Malilas
    WCU, Department of Cogno Mechatronics Engineering, Pusan National University, Busan 609 735, Republic of Korea
    Int J Oncol 43:1111-6. 2013

Scientific Experts

  • Soojin Lee
  • M Arfan Ikram
  • Christina T L Chen
  • Jessica J Lee
  • Younghwa Chun
  • Byoungwoo Park
  • Waraporn Malilas
  • Wansoo Koh
  • Hyejin Kim
  • John P Kemp
  • Agnieszka Kaczmarczyk
  • David M Evans
  • Ralf J P van der Valk
  • Nicholas J Timpson
  • Vincent W V Jaddoe
  • Beate St Pourcain
  • Andre G Uitterlinden
  • Carolina Medina-Gómez
  • Fernando Rivadeneira
  • Albert Hofman
  • George Davey Smith
  • Susan M Ring
  • Nicole M Warrington
  • Ratakorn Srisuttee
  • Young Hwa Chung
  • Il Rae Cho
  • Sang Seok Koh
  • Randal N Johnston
  • Jeong Moon
  • Raehyung Kim
  • W Malilas
  • Kevin F Sullivan
  • S S Koh
  • Timothy M Frayling
  • Mark I McCarthy
  • Rachel M Freathy
  • R Srisuttee
  • I R Cho
  • Y H Chung
  • R N Johnston
  • Lisa Prendergast
  • Miae Lee
  • Lihua Che
  • E H Park
  • Tetsuya Hori
  • Michael N Weedon
  • Monica Guxens
  • Clare S Murray
  • Alexessander Da Silva Couto Alves
  • Juan R Gonzalez
  • Anna Bergstrom
  • Marjan Kerkhof
  • Sylvain Sebert
  • Erik Melen
  • Jordi Sunyer
  • Olli T Raitakari
  • Alina Rodriguez
  • Riitta Veijola
  • H Rob Taal
  • Jonathan P Bradfield
  • Kalliope Panoutsopoulou
  • Claudia Flexeder
  • Harald Grallert
  • Eskil Kreiner-Møller
  • Ioanna Ntalla
  • Sabrina Llop
  • Johan Eriksson
  • Virpi Lindi
  • Frank Geller
  • Carla M T Tiesler
  • Johan C de Jongste
  • Tune H Pers
  • Sheila J Barton
  • Antje Körner
  • Joel N Hirschhorn
  • Patrick Eriksen
  • Johannes Waage
  • Elena Sergeyev
  • John W Holloway
  • Angela Simpson
  • Mariona Bustamante
  • Struan F A Grant
  • Eleftheria Zeggini
  • Verena Sengpiel
  • Elisabeth Widen
  • Elisabeth Thiering
  • Hakon Hakonarson
  • Anubha Mahajan
  • Frank D Mentch
  • Yik Ying Teo

Detail Information

Publications21

  1. doi CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Cell 135:1039-52. 2008
    ..In total, our results suggest that the CENP-T/CENP-W complex is directly involved in establishment of centromere chromatin structure coordinately with CENP-A...
  2. doi Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function
    Hyejin Kim
    Department of Microbiology, Chungnam National University, Daejeon 305 764, Korea
    Mol Cells 27:697-701. 2009
    We previously identified cancer-upregulated gene 2 (CUG2) as a commonly up-regulated gene in various human cancer tissues, especially in ovary, liver, and lung (Lee et al., 2007a)...
  3. pmc Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state
    Lisa Prendergast
    Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Ireland
    PLoS Biol 9:e1001082. 2011
    ..Segregation of the assembly mechanisms for the two allows the cell to switch between chromatin configurations that reciprocally support the replication of the centromere and its conversion to a mitotic state on postreplicative chromatin...
  4. pmc Centromere Protein (CENP)-W Interacts with Heterogeneous Nuclear Ribonucleoprotein (hnRNP) U and May Contribute to Kinetochore-Microtubule Attachment in Mitotic Cells
    Younghwa Chun
    Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, Daejeon, Republic of Korea
    PLoS ONE 11:e0149127. 2016
    ..CENP-W was identified as an inner centromere component that plays crucial roles in the formation of a functional kinetochore complex...
  5. doi A new kinetochore component CENP-W interacts with the polycomb-group protein EZH2 to promote gene silencing
    Wansoo Koh
    Department of Microbiology and Molecular Biology, College of Bioscience and Biotechnology, Chungnam National University, Daejeon 305 764, Republic of Korea
    Biochem Biophys Res Commun 464:256-62. 2015
    ..Collectively, this study suggests CENP-W is a novel kinetochore component that may be involved in the EZH2-mediated silencing machinery. ..
  6. pmc CENP-W plays a role in maintaining bipolar spindle structure
    Agnieszka Kaczmarczyk
    Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Ireland
    PLoS ONE 9:e106464. 2014
    ..Taken together, our findings are consistent with a model in which centrosome integrity is controlled by the pathways regulating kinetochore-microtubule attachment stability. ..
  7. pmc A novel common variant in DCST2 is associated with length in early life and height in adulthood
    Ralf J P van der Valk
    Department of Epidemiology, Department of Paediatrics, The Generation R Study Group
    Hum Mol Genet 24:1155-68. 2015
    ..known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2)...
  8. pmc Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment
    John P Kemp
    MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
    PLoS Genet 10:e1004423. 2014
    ..Allowing for these differences by performing genome-wide association at different skeletal sites may help uncover new genetic influences on BMD...
  9. doi Suppression of autophagic genes sensitizes CUG2-overexpressing A549 human lung cancer cells to oncolytic vesicular stomatitis virus-induced apoptosis
    Waraporn Malilas
    BK21, Department of Cogno Mechatronics Engineering, Pusan National University, Busan 609 735, Republic of Korea
    Int J Oncol 44:1177-84. 2014
    ..we investigated whether autophagy also plays a role in the antiviral activity in A549 cells overexpressing CUG2 (A549-CUG2)...
  10. doi Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation
    Waraporn Malilas
    WCU, Department of Cogno Mechatronics Engineering, Pusan National University, Busan 609 735, Republic of Korea
    Int J Oncol 43:1111-6. 2013
    ..We recently showed that CUG2 elevates STAT1 activity, leading to resistance to infection by oncolytic vesicular stomatitis virus...
  11. pmc CSN5/JAB1 interacts with the centromeric components CENP-T and CENP-W and regulates their proteasome-mediated degradation
    Younghwa Chun
    From the Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon 305 764, Korea
    J Biol Chem 288:27208-19. 2013
    ....
  12. pmc Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study
    Christina T L Chen
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Mol Genet 21:1419-32. 2012
    ..We replicated associations of eight loci (LRP18, LIN28B, CENPW, INHBA, TMEM38B, ZNF483, NFAT5 and OLFM2) with age at menarche, and of two loci (MCM8 and BRSK1/TMEM150B) with age ..
  13. doi Cancer upregulated gene 2, a novel oncogene, confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling
    W Malilas
    WCU, Department of Cogno Mechatronics Engineering, Pusan National University, Busan, Republic of Korea
    Cancer Gene Ther 20:125-32. 2013
    We have recently found a novel oncogene, named cancer upregulated gene 2 (CUG2), which activates Ras and mitogen-activated protein kinases (MAPKs), including ERK, JNK and p38 MAPK...
  14. pmc Common variants at 6q22 and 17q21 are associated with intracranial volume
    M Arfan Ikram
    Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:539-44. 2012
    ..5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size...
  15. pmc New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein
    Younghwa Chun
    Department of Microbiology and Molecular Biology, Chungnam National University, 305 764, Daejeon, Republic of Korea
    J Biol Chem 286:42758-69. 2011
    CENP-W was originally identified as a putative oncogene, cancer-upregulated gene 2 (CUG2) that was commonly up-regulated in many cancer tissues...
  16. ncbi Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2)
    Soojin Lee
    Department of Microbiology, Chungnam National University, Daejeon 305 764, Republic of Korea
    Biochem Biophys Res Commun 360:633-9. 2007
    ..Cancer-upregulated gene 2 (CUG2) was identified as an expressed sequence tag (EST) that exhibits significant differential expression in multiple ..
  17. pmc Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study
    Jessica J Lee
    Children s Hospital Boston, MA 02115, USA
    Ann Hum Genet 74:489-97. 2010
    ..This is the first report of a link between a stature-associated locus and growth impairment in CD...
  18. doi Cancer-upregulated gene 2 (CUG2) overexpression induces apoptosis in SKOV-3 cells
    Sunhee Lee
    Department of Microbiology, Chungnam National University, Daejeon, Republic of Korea
    Cell Biochem Funct 28:461-8. 2010
    Cancer-upregulated gene 2 (CUG2) was originally identified as a potential oncogene commonly up-regulated in various human cancers...
  19. doi Sp1 and Sp3 mediate basal and serum-induced expression of human CENP-W
    Hyejin Kim
    Department of Microbiology, Brain Korea 21 Project for Biological Science, Chungnam National University, Daejeon, 305 764, Republic of Korea
    Mol Biol Rep 37:3593-600. 2010
    Cancer-upregulated gene 2 (CUG2), which was named since it was originally identified as a putative oncogene up-regulated in various human cancers, was recently renamed CENP-W based on the new findings that it is a component of the ..
  20. doi CUG2, a novel oncogene confers reoviral replication through Ras and p38 signaling pathway
    E H Park
    Department of Cogno Mechatronics Engineering, BK21 Nanofusion Technology Team, Pusan National University, Miryang, Republic of Korea
    Cancer Gene Ther 17:307-14. 2010
    As we have recently found a novel oncogene, the cancer-upregulated gene 2 (CUG2), which was elevated in a variety of tumor tissues such as the ovary, liver, lung and pancreas, we examined whether reovirus could efficiently induce ..
  21. pmc Genome-wide association analysis identifies 20 loci that influence adult height
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 40:575-83. 2008
    ..Finally, our results provide insights into the genetic architecture of a classic quantitative trait...