CENPO

Summary

Gene Symbol: CENPO
Description: centromere protein O
Alias: CENP-O, ICEN-36, MCM21R, centromere protein O, centromeric protein O, interphase centromere complex protein 36
Species: human

Top Publications

  1. pmc Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly
    Alberto Toso
    Institute of Biochemistry, ETH Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 184:365-72. 2009
  2. ncbi The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres
    Masahiro Okada
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Nat Cell Biol 8:446-57. 2006
  3. ncbi Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells
    Hiroshi Izuta
    Bioscience and Biotechnology Center, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Genes Cells 11:673-84. 2006
  4. pmc The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation
    Andrew D McAinsh
    Department of Biology, MIT, Cambridge, MA, USA
    EMBO J 25:4033-49. 2006
  5. pmc The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity
    Sarah E McClelland
    Chromosome Segregation Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    EMBO J 26:5033-47. 2007
  6. ncbi The human CENP-A centromeric nucleosome-associated complex
    Daniel R Foltz
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Nat Cell Biol 8:458-69. 2006
  7. pmc GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
    J W Trampush
    Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA
    Mol Psychiatry . 2017
  8. pmc Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore
    Itaru Samejima
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, Scotland, UK
    J Cell Biol 211:1141-56. 2015
  9. pmc Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin
    Ronald B Walter
    Molecular Bioscience Research Group and Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, United States Electronic address
    Comp Biochem Physiol C Toxicol Pharmacol 178:93-103. 2015
  10. pmc Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways
    James Bancroft
    Mechanochemical Cell Biology Building, Division of Biomedical Cell Biology, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    J Cell Sci 128:171-84. 2015

Research Grants

  1. ENHANCED DEVELOPMENT OF THE XIPHOPHORUS MODEL SYSTEM
    RONALD WALTER; Fiscal Year: 2001
  2. TRANSPOSON ACTIVE TRANSGENIC XIPHOPHORUS
    RONALD WALTER; Fiscal Year: 2003
  3. THE XIPHOPHORUS GENETIC STOCK CENTER
    RONALD WALTER; Fiscal Year: 2006

Scientific Experts

  • RONALD WALTER
  • Andrew D McAinsh
  • Tatsuo Fukagawa
  • Tetsuya Hori
  • Marinela Perpelescu
  • Patrick Meraldi
  • J W Trampush
  • James Bancroft
  • Itaru Samejima
  • Masahiro Okada
  • Juri Rappsilber
  • Naoko Kagawa
  • Lakxmi Subramanian
  • Anja Eskat
  • Jonathan P Bradfield
  • Akiko Saito
  • Alberto Toso
  • Ana C Amaro
  • Jennifer R Winter
  • Masashi Ikeno
  • Kinya Yoda
  • Sarah E McClelland
  • Daniel R Foltz
  • John R Yates
  • Hiroshi Izuta
  • D E Arking
  • F W Sabb
  • S Le Hellard
  • P Bitsios
  • I Giegling
  • B Konte
  • V M Steen
  • M A Scult
  • G Davies
  • D C Glahn
  • T D Cannon
  • D Morris
  • A J Lundervold
  • J Yu
  • E Congdon
  • N Smyrnis
  • R M Bilder
  • N C Stefanis
  • M C Keller
  • D K Attix
  • R A Poldrack
  • S Giakoumaki
  • A K Malhotra
  • K Raikkonen
  • I Reinvang
  • D R Weinberger
  • A Hatzimanolis
  • E Widen
  • K E Burdick
  • P Roussos
  • I Melle
  • E Knowles
  • M L Z Yang
  • A R Hariri
  • A Payton
  • K Sundet
  • O A Andreassen
  • R E Straub
  • J Lahti
  • E D Conley
  • P DeRosse
  • J G Eriksson
  • G Donohoe
  • A C Need
  • D C Liewald
  • D Rujescu
  • M Gill
  • T Lencz
  • N A Freimer
  • A Corvin
  • S Djurovic
  • M Horan
  • J M Starr
  • O Chiba-Falek
  • E London
  • A Christoforou
  • D Avramopoulos
  • W Ollier
  • A Palotie
  • I J Deary
  • T Espeseth
  • D Dickinson
  • N Pendleton
  • E T Cirulli
  • A N Voineskos

Detail Information

Publications17

  1. pmc Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly
    Alberto Toso
    Institute of Biochemistry, ETH Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 184:365-72. 2009
    ..We previously found that depletion of the human kinetochore protein Mcm21R(CENP-O) results in monopolar spindles, raising the question as to whether kinetochores contribute to centrosome ..
  2. ncbi The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres
    Masahiro Okada
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Nat Cell Biol 8:446-57. 2006
    ....
  3. ncbi Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells
    Hiroshi Izuta
    Bioscience and Biotechnology Center, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Genes Cells 11:673-84. 2006
    ..These results suggest that the seven components of the ICEN complex are predominantly localized at the centromeres and are required for kinetochore function perhaps through or not through loading of CENP-H and hMis6 onto the centromere...
  4. pmc The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation
    Andrew D McAinsh
    Department of Biology, MIT, Cambridge, MA, USA
    EMBO J 25:4033-49. 2006
    ..determine whether similar linker activities are present at human KTs, we have compared the functions of Nnf1R and Mcm21R, recently identified MIND and COMA subunits, and Nuf2R, a well-characterized NDC80 subunit...
  5. pmc The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity
    Sarah E McClelland
    Chromosome Segregation Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    EMBO J 26:5033-47. 2007
    ..CENP-A NAC/CAD subunits can be assigned to one of two different functional classes; depletion of Class I proteins (Mcm21R(CENP-O) and Fta1R(CENP-L)) causes a failure in bipolar spindle assembly...
  6. ncbi The human CENP-A centromeric nucleosome-associated complex
    Daniel R Foltz
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Nat Cell Biol 8:458-69. 2006
    ..The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling...
  7. pmc GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
    J W Trampush
    Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA
    Mol Psychiatry . 2017
    ..Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the ..
  8. pmc Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore
    Itaru Samejima
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, Scotland, UK
    J Cell Biol 211:1141-56. 2015
    ..Our data also suggest that CENP-O and CENP-R may regulate the size of the inner kinetochore without influencing the assembly of the outer kinetochore. ..
  9. pmc Exposure to fluorescent light triggers down regulation of genes involved with mitotic progression in Xiphophorus skin
    Ronald B Walter
    Molecular Bioscience Research Group and Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, United States Electronic address
    Comp Biochem Physiol C Toxicol Pharmacol 178:93-103. 2015
    ..g., cenpe, cenpf, cenpi, cenpk, cenpo, cenpp, and cenpu; cep70; knstrm, kntc, mcm2, mcm5; smc2)...
  10. pmc Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways
    James Bancroft
    Mechanochemical Cell Biology Building, Division of Biomedical Cell Biology, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
    J Cell Sci 128:171-84. 2015
    ..Taken together, our data provide evidence that phosphoregulation of CENP-Q plays a central function in coordinating chromosome congression mechanisms...
  11. pmc Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly
    Lakxmi Subramanian
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, UK
    Open Biol 4:140043. 2014
    ..The novel interactions identified between CENP-A loading factors and the CCAN/Mis6/Ctf19 complex are likely to also contribute to CENP-A maintenance in other organisms. ..
  12. pmc The CENP-O complex requirement varies among different cell types
    Naoko Kagawa
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka, 411 8540, Japan
    Chromosome Res 22:293-303. 2014
    ..Thus, although both DT40 and ES cells with CENP-U deficiency have similar mitotic defects, cellular responses to mitotic defects vary among different cell types. ..
  13. pmc Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex
    Anja Eskat
    Molecular Biology, FLI, Jena, Germany
    PLoS ONE 7:e44717. 2012
    ....
  14. pmc A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci
    Jonathan P Bradfield
    The Center for Applied Genomics, The Children s Hospital Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002293. 2011
    ..of linkage disequilibrium is approximately 800 kb and harbors additional multiple genes, including NCOA1, C2orf79, CENPO, ADCY3, DNAJC27, POMC, and DNMT3A. The third most significantly associated SNP (rs924043, Pā€Š=ā€Š8...
  15. doi The ABCs of CENPs
    Marinela Perpelescu
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka, Japan
    Chromosoma 120:425-46. 2011
    ..This review presents discussion of the latest structural and functional data on CENP-A and CENPs from the CCAN as well as their interaction with the KMN network...
  16. doi CENP-O, a protein localized at the centromere throughout the cell cycle, is a novel target antigen in systemic sclerosis
    Akiko Saito
    Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Turumai cho Showa ku, Nagoya, 466 8550, Japan
    J Rheumatol 36:781-6. 2009
    ..The CENP-O protein is a component of the ICEN that localizes at the centromere throughout the cell cycle. We investigated whether CENP-O is also targeted by sera from patients with systemic autoimmune diseases...
  17. pmc CENP-O class proteins form a stable complex and are required for proper kinetochore function
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima 411 8540, Japan
    Mol Biol Cell 19:843-54. 2008
    ..This suggests that CENP-O class proteins are involved in the prevention of premature sister chromatid separation during recovery from spindle damage...

Research Grants3

  1. ENHANCED DEVELOPMENT OF THE XIPHOPHORUS MODEL SYSTEM
    RONALD WALTER; Fiscal Year: 2001
    ....
  2. TRANSPOSON ACTIVE TRANSGENIC XIPHOPHORUS
    RONALD WALTER; Fiscal Year: 2003
    ..abstract_text> ..
  3. THE XIPHOPHORUS GENETIC STOCK CENTER
    RONALD WALTER; Fiscal Year: 2006
    ..abstract_text> ..