CENPL

Summary

Gene Symbol: CENPL
Description: centromere protein L
Alias: C1orf155, CENP-L, dJ383J4.3, centromere protein L, interphase centromere complex protein 33
Species: human

Top Publications

  1. doi Pituitary deficiency and congenital infiltrating lipomatosis of the face in a girl with deletion of chromosome 1q24.3q31.1
    V Capra
    U O Neurochirurgia, Istituto G Gaslini, Genova, Italy
    Am J Med Genet A 164:495-9. 2014
  2. doi Identifying novel oncogenes: a machine learning approach
    Ambuj Kumar
    Bioinformatics Division, School of Bio Sciences and Technology, Vellore Institute of Technology University, Vellore, 632014, Tamil Nadu, India
    Interdiscip Sci 5:241-6. 2013
  3. pmc Dynamic changes in CCAN organization through CENP-C during cell-cycle progression
    Harsh Nagpal
    Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan Department of Molecular Genetics, National Institute of Genetics and Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Mol Biol Cell 26:3768-76. 2015
  4. pmc The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface
    Kara L McKinley
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Mol Cell 60:886-98. 2015
  5. doi Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation
    Nunu McHedlishvili
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland
    J Cell Sci 125:906-18. 2012
  6. pmc Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex
    Anja Eskat
    Molecular Biology, FLI, Jena, Germany
    PLoS ONE 7:e44717. 2012
  7. doi Structural insights into the role of the Chl4-Iml3 complex in kinetochore assembly
    Qiong Guo
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People s Republic of China
    Acta Crystallogr D Biol Crystallogr 69:2412-9. 2013
  8. ncbi The human CENP-A centromeric nucleosome-associated complex
    Daniel R Foltz
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Nat Cell Biol 8:458-69. 2006
  9. ncbi The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres
    Masahiro Okada
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Nat Cell Biol 8:446-57. 2006
  10. ncbi Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells
    Hiroshi Izuta
    Bioscience and Biotechnology Center, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Genes Cells 11:673-84. 2006

Detail Information

Publications14

  1. doi Pituitary deficiency and congenital infiltrating lipomatosis of the face in a girl with deletion of chromosome 1q24.3q31.1
    V Capra
    U O Neurochirurgia, Istituto G Gaslini, Genova, Italy
    Am J Med Genet A 164:495-9. 2014
    ..3q31.1, which was defined by array-CGH. The deleted region contains numerous genes, but only eight (CENPL, LHX4, LAMC1, LAMC2, PTGS2, ANGPTL1, TNN, and TNR) are good candidates to explain, at least partially, the ..
  2. doi Identifying novel oncogenes: a machine learning approach
    Ambuj Kumar
    Bioinformatics Division, School of Bio Sciences and Technology, Vellore Institute of Technology University, Vellore, 632014, Tamil Nadu, India
    Interdiscip Sci 5:241-6. 2013
    ..We observed multiple evidences of cancer associated genetic mutations in CENPI, CENPJ, CENPK, CENPL and CENPX protein...
  3. pmc Dynamic changes in CCAN organization through CENP-C during cell-cycle progression
    Harsh Nagpal
    Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan Department of Molecular Genetics, National Institute of Genetics and Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Mol Biol Cell 26:3768-76. 2015
    ..On the basis of these results, we propose that CCAN organization changes dynamically during progression of the cell cycle. ..
  4. pmc The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface
    Kara L McKinley
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Mol Cell 60:886-98. 2015
    ..Thus, an interdependent meshwork within the CCAN underlies the centromere specificity and stability of the kinetochore...
  5. doi Kinetochores accelerate centrosome separation to ensure faithful chromosome segregation
    Nunu McHedlishvili
    Institute of Biochemistry, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland
    J Cell Sci 125:906-18. 2012
    ..We propose that the kinetochore pushing force is an essential safety mechanism that favors amphitelic attachments by ensuring that spindle bipolarization occurs before the formation of the majority of kinetochore-microtubule attachments...
  6. pmc Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex
    Anja Eskat
    Molecular Biology, FLI, Jena, Germany
    PLoS ONE 7:e44717. 2012
    ....
  7. doi Structural insights into the role of the Chl4-Iml3 complex in kinetochore assembly
    Qiong Guo
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, People s Republic of China
    Acta Crystallogr D Biol Crystallogr 69:2412-9. 2013
    ..Acting as a heterodimer, the Chl4-Iml3 complex exhibits a low-affinity nonspecific DNA-binding activity which may play an important role in the kinetochore-assembly process. ..
  8. ncbi The human CENP-A centromeric nucleosome-associated complex
    Daniel R Foltz
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Nat Cell Biol 8:458-69. 2006
    ..The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling...
  9. ncbi The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres
    Masahiro Okada
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Nat Cell Biol 8:446-57. 2006
    ....
  10. ncbi Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells
    Hiroshi Izuta
    Bioscience and Biotechnology Center, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Genes Cells 11:673-84. 2006
    ..These results suggest that the seven components of the ICEN complex are predominantly localized at the centromeres and are required for kinetochore function perhaps through or not through loading of CENP-H and hMis6 onto the centromere...
  11. pmc The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity
    Sarah E McClelland
    Chromosome Segregation Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, UK
    EMBO J 26:5033-47. 2007
    ..Based on our results, we propose that the cooperative action of CENP-A NAC/CAD subunits and the KMN network drives efficient chromosome segregation and bipolar spindle assembly during mitosis...
  12. doi CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis
    Koichi Tanaka
    Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113 0032, Japan
    Dev Cell 17:334-43. 2009
    ..Overall, therefore, our studies identify effectors of CENP-C in mitosis and meiosis and establish the concept that CENP-C serves as a scaffold for the specific recruitment of essential kinetochore proteins...
  13. pmc Distinctive phenotype in 9 patients with deletion of chromosome 1q24-q25
    Deepika D Cunha Burkardt
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Am J Med Genet A 155:1336-51. 2011
    ..9 Mb at 1q24.3q25.1 (chr1: 170,135,865-172,099,327, hg18 coordinates), containing 13 genes and including CENPL, which encodes centromeric protein L, a protein essential for proper kinetochore function and mitotic progression...
  14. doi The ABCs of CENPs
    Marinela Perpelescu
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka, Japan
    Chromosoma 120:425-46. 2011
    ..This review presents discussion of the latest structural and functional data on CENP-A and CENPs from the CCAN as well as their interaction with the KMN network...