CENPH

Summary

Gene Symbol: CENPH
Description: centromere protein H
Alias: centromere protein H, CENP-H, interphase centromere complex protein 35, kinetochore protein CENP-H
Species: human

Top Publications

  1. ncbi Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells
    Hiroshi Izuta
    Bioscience and Biotechnology Center, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Genes Cells 11:673-84. 2006
  2. ncbi The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres
    Masahiro Okada
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Nat Cell Biol 8:446-57. 2006
  3. ncbi Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes
    N Sugata
    Tsukuba Life Science Center, The Institute of Physical and Chemical Research RIKEN, 3 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Hum Mol Genet 9:2919-26. 2000
  4. pmc Prognostic relevance of Centromere protein H expression in esophageal carcinoma
    Xian Zhi Guo
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, PR China
    BMC Cancer 8:233. 2008
  5. ncbi Transcription within a functional human centromere
    Richard Saffery
    The Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Melbourne, 3052, Australia
    Mol Cell 12:509-16. 2003
  6. pmc Upregulation of CENP-H in tongue cancer correlates with poor prognosis and progression
    Wen Ting Liao
    Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Sun Yat sen University, Guangzhou, PR China
    J Exp Clin Cancer Res 28:74. 2009
  7. pmc KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates
    Iain M Cheeseman
    Ludwig Institute for Cancer Research, and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 19:587-94. 2008
  8. pmc Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres
    Alicia Alonso
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Genome Biol 8:R148. 2007
  9. ncbi A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1
    Chikashi Obuse
    Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
    Nat Cell Biol 6:1135-41. 2004
  10. pmc The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis
    Yoshikazu Mikami
    PRESTO of JST, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Mol Cell Biol 25:1958-70. 2005

Scientific Experts

  • Mari Shimura
  • Ghia M Euskirchen
  • Georjana Barnes
  • Yue Zhong Li
  • T Tomonaga
  • IAIN MCPHERSON CHEESEMAN
  • Xian Zhi Guo
  • Wen Ting Liao
  • A W Lo
  • Marcin R Przewloka
  • Xiao jing Chen
  • Jing Feng
  • Xia Sun
  • Masahiro Okada
  • Jing Yi Zhao
  • Ganesh Chauhan
  • Magdalena M Richter
  • Teng Zhang
  • Wen qing Huang
  • Ariane C Blattner
  • Yahui Liu
  • Amanda M Carpenter
  • Yoana N Dimitrova
  • Lijuan Zhu
  • Xun Wu
  • Weicong Qi
  • Emily M Kudalkar
  • Tatsuo Fukagawa
  • Jing Ping Zhang
  • Mihyang Kim
  • Man Zhi Li
  • W L He
  • Raju Kandimalla
  • Sharmini Alagaratnam
  • Hong bo Wang
  • Guifang Lu
  • John R Yates
  • X Shawn Liu
  • Chikashi Obuse
  • Jun Xi Wang
  • Tianyi Quan
  • Wei Feng Zhao
  • Anke Samel
  • Khaoula Hamdouch
  • Young H Kang
  • Xinyi Zhao
  • Debaditya Mukhopadhyay
  • Naoto Miyajima
  • Jan Karl Burkhardt
  • N Sugata
  • Ainel Aleman
  • Katsuya Okawa
  • Yasuyo Kobayashi
  • Alicia Alonso
  • Kinya Yoda
  • Hiroshi Izuta
  • Daniel R Foltz
  • Sandra Orthaus
  • Tzvi Aviv
  • Tetsuya Hori
  • Michael W Mangan
  • Yoshikazu Mikami
  • Günter Harth
  • David M Glover
  • Pascaline Rombaut
  • Liang liang Cai
  • Stephanie Debette
  • Kui Han
  • Chi Meng Tzeng
  • Roberto Valverde
  • Arsen Petrovic
  • Shyamal Mosalaganti
  • Simon Jenni
  • Stefan Raunser
  • Jaroslaw Poznanski
  • Li Li
  • Ke Hui Yi
  • Qing Yuan Sun
  • Heide Schatten
  • Wei Shen
  • Mariusz Czarnocki-Cieciura
  • Qing Lin
  • Benjamin A Pinsky
  • Zhen Bo Wang
  • Zoltán Lipinszki
  • Yang Zhou
  • Li Zhuo
  • Jose Aguilar-Rodríguez
  • Inder P Singh
  • Andrea Musacchio

Detail Information

Publications63

  1. ncbi Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells
    Hiroshi Izuta
    Bioscience and Biotechnology Center, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Genes Cells 11:673-84. 2006
    ..These results suggest that the seven components of the ICEN complex are predominantly localized at the centromeres and are required for kinetochore function perhaps through or not through loading of CENP-H and hMis6 onto the centromere...
  2. ncbi The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres
    Masahiro Okada
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Nat Cell Biol 8:446-57. 2006
    ....
  3. ncbi Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere--kinetochore complexes
    N Sugata
    Tsukuba Life Science Center, The Institute of Physical and Chemical Research RIKEN, 3 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Hum Mol Genet 9:2919-26. 2000
    ..These results suggest that CENP-H multimers localize constitutively to the inner kinetochore plate and play an important fundamental role in organization and function of the active human centromere-kinetochore complex...
  4. pmc Prognostic relevance of Centromere protein H expression in esophageal carcinoma
    Xian Zhi Guo
    State Key Laboratory of Oncology in Southern China, Sun Yat sen University Cancer Center, Guangzhou, PR China
    BMC Cancer 8:233. 2008
    ..The aim of the present study was to clarify the expression of Centromere protein H (CENP-H), one of the fundamental components of the human active kinetochore, in esophageal carcinoma and ..
  5. ncbi Transcription within a functional human centromere
    Richard Saffery
    The Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Melbourne, 3052, Australia
    Mol Cell 12:509-16. 2003
    ....
  6. pmc Upregulation of CENP-H in tongue cancer correlates with poor prognosis and progression
    Wen Ting Liao
    Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Sun Yat sen University, Guangzhou, PR China
    J Exp Clin Cancer Res 28:74. 2009
    b>Centromere protein H (CENP-H) is one of the fundamental components of the human active kinetochore. Recently, CENP-H was identified to be associated with tumorigenesis...
  7. pmc KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates
    Iain M Cheeseman
    Ludwig Institute for Cancer Research, and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 19:587-94. 2008
    ..These findings explain discrepancies in kinetochore assembly pathways between different organisms and reveal a surprising plasticity in the assembly mechanism of an essential cell division organelle...
  8. pmc Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres
    Alicia Alonso
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Genome Biol 8:R148. 2007
    ..Neocentromeres permit detailed investigation of centromeric chromatin organization that is not possible in the highly repetitive alpha satellite DNA present at endogenous centromeres...
  9. ncbi A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1
    Chikashi Obuse
    Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Yoshida Honmachi, Sakyo ku, Kyoto 606 8501, Japan
    Nat Cell Biol 6:1135-41. 2004
    ..Double HP1 RNAi abolishes kinetochore localization of hMis12 and DC8. Therefore, centromeric HP1 may be the base to anchor the hMis12 core complex that is enriched with coiled coils and extends to outer Zwint-1 during mitosis...
  10. pmc The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis
    Yoshikazu Mikami
    PRESTO of JST, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Mol Cell Biol 25:1958-70. 2005
    ..On the basis of these results and previously published data, we propose that the Nuf2 complex functions as a connector between the inner and outer kinetochores...
  11. ncbi The human CENP-A centromeric nucleosome-associated complex
    Daniel R Foltz
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Nat Cell Biol 8:458-69. 2006
    ..The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling...
  12. ncbi Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy
    Takeshi Tomonaga
    Department of Molecular Diagnosis F8, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Cancer Res 65:4683-9. 2005
    ..These results suggest that the aberrant expression and localization of a kinetochore protein CENP-H plays an important role in the aneuploidy frequently observed in colorectal cancers...
  13. ncbi Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival
    Wen Ting Liao
    State Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, China
    Clin Cancer Res 13:508-14. 2007
    The aim of the present study was to analyze the expression of Centromere protein H (CENP-H), one of the fundamental components of the human active kinetochore, in nasopharyngeal carcinoma (NPC) and to correlate it with clinicopathologic ..
  14. doi Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival
    Wen Ting Liao
    State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, China
    Cancer 115:1507-17. 2009
    ..The objective of the current study was to investigate the expression pattern and clinicopathologic significance of centromere protein H (CENP-H) in patients with nonsmall cell lung cancer (NSCLC).
  15. ncbi RNAi knockdown of human kinetochore protein CENP-H
    Sandra Orthaus
    Department of Molecular Biology, FLI e V, Beutenbergstrasse 11, D 07745 Jena, Germany
    Biochem Biophys Res Commun 348:36-46. 2006
    ..In CENP-H knocked-down human cells, the misaligned chromosomes contained only reduced levels of CENP-E. Our data clearly indicate that CENP-H has an important impact on the architecture and function of the human kinetochore complex...
  16. pmc Mitotic Protein CSPP1 Interacts with CENP-H Protein to Coordinate Accurate Chromosome Oscillation in Mitosis
    Lijuan Zhu
    From the Laboratory for Cellular Dynamics, University of Science and Technology of China, Hefei 230027, China
    J Biol Chem 290:27053-66. 2015
    ..Based on these findings, we propose that CSPP1 cooperates with CENP-H on kinetochores to serve as a novel regulator of kMT dynamics for accurate chromosome segregation...
  17. pmc Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex
    Emily M Kudalkar
    Department of Biochemistry, University of Washington, Seattle, WA 98195
    Proc Natl Acad Sci U S A 112:E5583-9. 2015
    ..Together, our results suggest a previously unidentified mechanism for regulating microtubule binding of an outer kinetochore component by a central kinetochore complex. ..
  18. pmc The SUMO protease SENP6 is essential for inner kinetochore assembly
    Debaditya Mukhopadhyay
    Laboratory of Gene Regulation and Development, National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 188:681-92. 2010
    ..Together, these findings reveal a novel mechanism whereby the finely balanced activities of SENP6 and RNF4 control vertebrate kinetochore assembly through SUMO-targeted destabilization of inner plate components...
  19. pmc The complete genome sequence and analysis of a plasmid-bearing myxobacterial strain Myxococcus fulvus 124B02 (M 206081)
    Xiao jing Chen
    State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan, 250100 China
    Stand Genomic Sci 11:1. 2016
    ..Comparative genomic analyses suggest that pMF1 has a longstanding sustention within myxobacteria, and probably contributes to the genome expansion of myxobacteria. ..
  20. pmc Screening for recombinants of Crambe abyssynica after transformation by the pMF1 marker-free vector based on chemical selection and meristematic regeneration
    Weicong Qi
    Jiangsu Key Laboratory for Bioresources of Saline Soils, Provincial Key Laboratory of Agrobiology, Institute of Biotechnology, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, Jiangsu, People s Republic of China
    Sci Rep 5:14033. 2015
    ....
  21. doi Upregulation of centromere protein H is associated with progression of renal cell carcinoma
    Xun Wu
    Department of Anatomy, School of Basic Medicine Science, Southern Medical University, Guangzhou, 510515, Guangdong, China
    J Mol Histol 46:377-85. 2015
    b>Centromere protein H (CENPH), one of the essential component of active kinetochore, plays an important role in carcinogenesis of many cancer types...
  22. pmc Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores
    Young H Kang
    Laboratory of Metabolism, Center for Cancer Research, NCI National Institutes of Health, Bethesda, Maryland 20892 4258, USA
    J Biol Chem 286:19744-57. 2011
    ....
  23. pmc Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation
    Mari Shimura
    Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Shinjuku, Tokyo 162 8655, Japan
    J Cell Biol 194:721-35. 2011
    ..Our study reveals for the first time centromere cohesion impairment resulting from epigenetic disruption of higher-order structures of heterochromatin by a viral pathogen...
  24. doi Metabolism of Kaempferia parviflora polymethoxyflavones by human intestinal bacterium Bautia sp. MRG-PMF1
    Mihyang Kim
    Metalloenzyme Research Group and Department of Systems Biotechnology, Chung Ang University, Anseong 456 756, Republic of Korea
    J Agric Food Chem 62:12377-83. 2014
    ..The unprecedented PMF demethylation activity of Blautia sp. MRG-PMF1 will expand our understanding of flavonoid metabolism in the human intestine and lead to novel bioactive compounds. ..
  25. pmc Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma
    Jing Ping Zhang
    J Transl Med 12:222. 2014
    ..carcinoma (NPC), including B-lymphoma mouse Moloney leukemia virus insertion region 1 (Bmi1) and centromere protein H (CENPH), but the role of Sp1 and its underlying mechanisms in NPC remained largely unexplored...
  26. doi Overexpression of CENP-H as a novel prognostic biomarker for human hepatocellular carcinoma progression and patient survival
    Guifang Lu
    Department of Gastroenterology, First Affiliated Hospital of the Medical College, Xi an Jiaotong University, Xi an, Shaanxi 710061, P R China
    Oncol Rep 30:2238-44. 2013
    b>Centromere protein H (CENP-H) has been shown to be significantly upregulated in many types of cancers and is associated with disrupted cell cycle regulation, cell proliferation and genetic instability...
  27. ncbi CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes
    Teng Zhang
    State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Development . 2016
    ..Here, we report that CenpH, a component of the kinetochore inner plate protein, is responsible for the G2/M transition in meiotic mouse ..
  28. ncbi Drosophila Nnf1 paralogs are partially redundant for somatic and germ line kinetochore function
    Ariane C Blattner
    Institute of Molecular Life Sciences IMLS, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Chromosoma . 2016
    ..Loss of both paralogs results in developmental lethality. We therefore conclude that the two paralogs are still in early stages of differentiation...
  29. pmc Network of protein interactions within the Drosophila inner kinetochore
    Magdalena M Richter
    Department of Genetics, University of Cambridge, Cambridge, UK Institute of Biochemistry and Biophysics, Polish Academy of Science, Warsaw, Poland
    Open Biol 6:150238. 2016
    ..Thus, we conclude the organization of the Mis12-Nnf1 dimer confers upon the Mis12 complex a bipolar, elongated structure that is critical for kinetochore function. ..
  30. pmc Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster
    Yahui Liu
    Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto Hahn Straße 11, 44227 Dortmund, Germany
    Open Biol 6:150236. 2016
    ..Our studies shed light on the structural and functional organization of a highly divergent kinetochore particle. ..
  31. pmc Analysis of genetic polymorphisms associated with leukoaraiosis in the southern Chinese population: A case-control study
    Wen qing Huang
    aTranslational Medicine Research Center bKey Laboratory for Cancer T Cell Theranostics and Clinical Translation cMaternity and Child Health Hospital, Xiamen, Fujian, China dDepartment of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian eINNOVA Cell TDx Clinics and TRANSLA Health Group, China
    Medicine (Baltimore) 95:e3857. 2016
    ..Thus, we believe that a genome-wide association study and candidate gene association studies are needed to reassess the previous findings and screen novel risk genes for LA in China. ..
  32. pmc Genetic Risk Factors for Ischemic and Hemorrhagic Stroke
    Ganesh Chauhan
    Inserm U1219 Bordeaux Population Health Research Center, 146, rue Leo Saignat, 33000, Bordeaux, France
    Curr Cardiol Rep 18:124. 2016
    ..For hemorrhagic stroke, two loci (APOE and PMF1) have been identified...
  33. doi Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly
    Yoana N Dimitrova
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA
    Cell 167:1014-1027.e12. 2016
    ..A C-terminal extension of Dsn1 recruits Ndc80C to the opposite end of the shaft. The structure and properties of MIND show how it integrates phospho-regulatory inputs for kinetochore assembly and disassembly...
  34. doi Genetic risk factors for spontaneous intracerebral haemorrhage
    Amanda M Carpenter
    St George s University, 3500 Sunrise Highway, Great River, NY 11739, USA
    Nat Rev Neurol 12:40-9. 2016
    ..Although evidence for genetic contributions to the risk of ICH exists, we do not yet fully understand how and to what extent this information can be utilized to prevent and treat ICH. ..
  35. ncbi Assignment of the centromere protein H (Cenph) gene to mouse chromosome band 13D1 by in situ hybridization and interspecific backcross analyses
    A W Lo
    The Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Melbourne, Victoria, Australia
    Cytogenet Cell Genet 90:56-7. 2000
  36. doi DNA methylation-based biomarkers in bladder cancer
    Raju Kandimalla
    Department of Pathology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Nat Rev Urol 10:327-35. 2013
    ..Validated markers for progression, diagnosis, survival and BCG response will contribute to clinical decision-making and individualized treatment...
  37. doi Transforming pluripotency: an exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells
    Sharmini Alagaratnam
    Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway
    Stem Cells Dev 22:1136-46. 2013
    ..These findings are of particular interest for both GCT and ES cell biology, and, in general, to the concept of CSCs...
  38. doi Combined evaluation of centromere protein H and Ki-67 as prognostic biomarker for patients with gastric carcinoma
    W L He
    Department of Gastrointestinal and Pancreatic Surgery and Centre of Gastric Cancer, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510080, PR China
    Eur J Surg Oncol 39:141-9. 2013
    b>Centromere protein H (CENP-H) is one of the essential components of the human active kinetochore which close links with carcinogenesis. Its expression and clinical value of prognostic prediction for gastric cancer (GC) is unclear.
  39. pmc Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment
    X Shawn Liu
    Department of Biochemistry, Purdue University, West Lafayette, IN, USA
    Mol Cell Biol 32:4053-67. 2012
    ..Our results demonstrate a mechanism for Plk1 in promoting kinetochore-microtubule attachment to ensure chromosome stability...
  40. ncbi Role of centromere protein H and Ki67 in relapse-free survival of patients after primary surgery for hypopharyngeal cancer
    Jun Xi Wang
    Department of Otolaryngology Head and Neck Surgery, Qi Lu Hospital, Shandong University, Jinan, China
    Asian Pac J Cancer Prev 13:821-5. 2012
    b>Centromere protein H (CENP-H) and Ki67 are overexpressed in some malignancies, but whether they are predictors of survival after primary resection for hypopharyngeal squamous cell carcinoma (HSCC) remains unknown.
  41. pmc Methylation of CenH3 arginine 37 regulates kinetochore integrity and chromosome segregation
    Anke Samel
    Abteilung fur Genetik, Zentrum für Medizinische Biotechnologie, Universitat Duisburg Essen, D 45141 Essen, Germany
    Proc Natl Acad Sci U S A 109:9029-34. 2012
    ..Altogether, our data identify a unique regulatory principle on centromeric chromatin by posttranslational modification of the amino terminus of CenH3...
  42. ncbi [Role of centromere protein H in human gastric cancer cell proliferation]
    Tianyi Quan
    Department of Oncology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 32:265-9. 2012
    To explore the role of centromere protein H (CENP-H) in the proliferation of human gastric cancer cells.
  43. pmc Overexpression of centromere protein H is significantly associated with breast cancer progression and overall patient survival
    Wen Ting Liao
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P R China
    Chin J Cancer 30:627-37. 2011
    ..This study aimed to analyze the expression of centromere protein H (CENP-H) in breast cancer and to correlate it with clinicopathologic data, including patient survival...
  44. doi Characterization of the replication origin of the myxobacterial self-replicative plasmid pMF1
    Jing Feng
    State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan 250100, China
    Plasmid 68:105-12. 2012
    ..14, and was found to contain several directly and inverted atypical repeats. The unique characteristics of the pMF1 replicon are suggested to be the reason for its strict narrow host range in Myxococcus cells...
  45. doi Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells
    Wei Feng Zhao
    State Key Laboratory of Oncology in South China, SunYat sen University Cancer Center, Guangzhou, China
    FEBS J 279:2714-26. 2012
    The overexpression of centromere protein H (CENPH), one of the fundamental components of the human active kinetochore, has been shown to be closely associated with human cancers...
  46. ncbi A two-plasmid system for stable, selective-pressure-independent expression of multiple extracellular proteins in mycobacteria
    Günter Harth
    Division of Infectious Diseases, Department of Medicine, 37 121 CHS, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1688, USA
    Microbiology 150:2143-51. 2004
    ..coli or between E. coli strains. The combination of two compatible plasmids in one BCG strain allows expression of recombinant mycobacterial proteins at different levels, a potentially important factor in optimizing vaccine potency...
  47. ncbi Versatile Rhodococcus equi-Escherichia coli shuttle vectors
    Michael W Mangan
    Department of Industrial Microbiology, Conway Institute for Biomolecular and Biomedical Reseach, University College Dublin, Dublin 4, Ireland
    Antonie Van Leeuwenhoek 87:161-7. 2005
    ..The stability of these plasmids in R. equi in the absence of selection for the plasmid borne antibiotic resistance markers, and their integrity following passage through Escherichia coli and R. equi was determined...
  48. pmc Interruption of cenph causes mitotic failure and embryonic death, and its haploinsufficiency suppresses cancer in zebrafish
    Xinyi Zhao
    Protein Science Laboratory of the Ministry of the Education, College of Life Sciences, Tsinghua University, Beijing 100084, China
    J Biol Chem 285:27924-34. 2010
    ..mutant, stagnant and curly (stac), that carries the Tol2 transposon element inserted at the kinetochore protein H (cenph) locus...
  49. pmc Characterization of the partitioning system of Myxococcus plasmid pMF1
    Xia Sun
    State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan, China
    PLoS ONE 6:e28122. 2011
    ..The ParB-binding iteron sequences are distributed not only near the partitioning gene loci but also along pMF1. These results indicate that the pMF1 par system has novel structural and functional characteristics...
  50. doi Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases
    Khaoula Hamdouch
    Departamento de Biomedicina, Biotecnología y Salud Pública, Facultad de Ciencias, 11510 Puerto Real, Cadiz, Spain
    Clin Chim Acta 412:2267-71. 2011
    ..centromere autoantigens described so far include constitutive kinetochore proteins such as CENPA, CENPB, CENPC and CENPH and facultative proteins such as CENPE, CENPF and INCENP...
  51. doi CENP-C is a structural platform for kinetochore assembly
    Marcin R Przewloka
    Department of Genetics, University of Cambridge, Cambridge, UK
    Curr Biol 21:399-405. 2011
    ..Thus, the N-terminal part of Drosophila CENP-C is sufficient to recruit core kinetochore components and acts as the principal linkage between centromere and kinetochore during mitosis...
  52. ncbi NNF1 is an essential yeast gene required for proper spindle orientation, nucleolar and nuclear envelope structure and mRNA export
    X Shan
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Cell Sci 110:1615-24. 1997
    ..Our results suggest that Nnf1p plays a role in a number of nuclear functions...
  53. pmc CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1
    Masahiro Okada
    Center for Priority Areas, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan Department of Chemistry, Graduate School of Sciences and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo 192 0397, Japan Innovative Drug Research Laboratories, Kyowa Hakko Kirin Co, Ltd, Takasaki, Gumma, 370 1295, Japan
    Mol Biol Cell 20:3986-95. 2009
    ..These findings indicate that the CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1...
  54. doi TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression
    Naoto Miyajima
    Department of Biochemistry, Hokkaido University Graduate School of Medicine, N15, W7, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    Biochem Biophys Res Commun 381:383-7. 2009
    ..These results indicate that TRIM36 is potentially associated with chromosome segregation and that an excess of TRIM36 may cause chromosomal instability...
  55. doi Identification of PMF1 methylation in association with bladder cancer progression
    Ainel Aleman
    Tumor Markers Group, Molecular Pathology Program, Spanish National Cancer Center, Madrid, Spain
    Clin Cancer Res 14:8236-43. 2008
    ..The polyamine modulated factor-1 (PMF-1) is involved in polyamine homeostasis. After identifying an enriched CpG island encompassing the PMF1 promoter, we aimed at evaluating the clinical relevance of PMF1 methylation in bladder cancer...
  56. doi Real-time RT-PCR discriminating mRNA encoding osteocalcin from unspecific targets
    Jan Karl Burkhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany
    Anal Bioanal Chem 393:1351-5. 2009
    ..It was found that the classic method that does not correct for PMF1 expression leads to overestimations as high as 70%...
  57. pmc Discovery of the autonomously replicating plasmid pMF1 from Myxococcus fulvus and development of a gene cloning system in Myxococcus xanthus
    Jing Yi Zhao
    State Key Laboratory of Microbial Technology, College of Life Science, Shandong University, Jinan 250100, People s Republic of China
    Appl Environ Microbiol 74:1980-7. 2008
    ..The transformants subsequently exhibited the ability to form pili and social motility. Autonomously replicating plasmid pMF1 provides a new tool for genetic manipulation in Myxococcus...
  58. ncbi The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins
    Yasuyo Kobayashi
    Division of Cell Biology, Institute of Life Science, Kurume University, Fukuoka, 839 0864, Japan
    Genes Cells 12:311-28. 2007
    ..These genetic interactions highlight the DASH-action(s) in satisfying SAC when aneuploids are formed during mitosis in the inner-kinetochore-defective mis mutants...
  59. ncbi Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p
    Tzvi Aviv
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5, Canada
    Nat Struct Mol Biol 13:168-76. 2006
    ..Bioinformatic analysis of these mRNAs demonstrates that the RNA-binding specificity of Vts1p in vivo is probably more stringent than that of the isolated SAM domain in vitro...
  60. ncbi An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase
    Benjamin A Pinsky
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 5:735-45. 2003
    ..We therefore propose that an Mtw1 complex is required for kinetochore biorientation that is monitored by the Ipl1p kinase...
  61. pmc Architecture of the budding yeast kinetochore reveals a conserved molecular core
    Stefan Westermann
    Department of Molecular and Cell Biology, Barker Hall, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 163:215-22. 2003
    ..We propose that a molecular core consisting of CENP-A, -C, -H, and Ndc80/HEC has been conserved from yeast to humans to link centromeres to spindle microtubules...
  62. pmc Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae
    Ghia M Euskirchen
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Eukaryot Cell 1:229-40. 2002
    ..Based on the colocalization of these four proteins, the minichromosome instability and the spindle defects seen in nnf1 mutants, I propose that Nnf1p is part of a new group of proteins necessary for chromosome segregation...
  63. ncbi Characterization of a novel kinetochore protein, CENP-H
    N Sugata
    Tsukuba Life Science Center, The Institute of Physical and Chemical Research RIKEN, 3 1, Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    J Biol Chem 274:27343-6. 1999
    ..Thus the newly isolated CENP-H may play a role in kinetochore organization and function throughout the cell cycle...