CELA3B

Summary

Gene Symbol: CELA3B
Description: chymotrypsin like elastase family member 3B
Alias: CBPP, ELA3B, chymotrypsin-like elastase family member 3B, cholesterol-binding pancreatic protease, elastase 3B, pancreatic, elastase IIIB, elastase-3B, fecal elastase 1, pancreatic elastase 1, pancreatic endopeptidase E, protease E, proteinase E
Species: human

Top Publications

  1. ncbi The interaction of alpha-1-antitrypsin with chymotrypsin, trypsin and elastase
    A B Cohen
    Biochim Biophys Acta 391:193-200. 1975
  2. ncbi Evaluation of fecal pancreatic elastase-1 as a measure of pancreatic exocrine function in children with cystic fibrosis
    A Cade
    Regional Paediatric Cystic Fibrosis Unit, St James s University Hospital, Leeds, UK
    Pediatr Pulmonol 29:172-6. 2000
  3. ncbi Pancreatic elastase-1 in stools, a marker of exocrine pancreas function, correlates with both residual beta-cell secretion and metabolic control in type 1 diabetic subjects
    Franco Cavalot
    University of Turin, San Luigi Gonzaga Hospital, Department of Clinical and Biological Sciences, Diabetes Unit, 10043 Orbassano TO, Turin, Italy
    Diabetes Care 27:2052-4. 2004
  4. ncbi Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial
    Nils Ewald
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Diabetes Metab Res Rev 23:386-91. 2007
  5. ncbi Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3
    Mette Vesterhus
    Department of Pediatrics, Haukeland University Hospital, Bergen, Norway
    Diabetes Care 31:306-10. 2008
  6. ncbi Fecal elastase 1 and vitamin D3 in patients with osteoporotic bone fractures
    Sacha T W Mann
    Department of Internal Medicine, Medical Clinic III and Polyclinic of the Justus Liebig University, Giessen, Germany
    Eur J Med Res 13:68-72. 2008
  7. doi Low fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus
    Jan Uwe Hahn
    Clinic for Diabetes and Metabolic Diseases, Klinikum Karlsburg, Karlsburg, Germany
    Pancreas 36:274-8. 2008
  8. ncbi Comparing the urinary pancreolauryl ratio and faecal elastase-1 as indicators of pancreatic insufficiency in clinical practice
    D A Elphick
    Department of Gastroenterology, Barnsley District General Hospital, Barnsley, UK
    Pancreatology 5:196-200. 2005
  9. pmc Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells
    Gerald Misinzo
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    J Virol 82:1128-35. 2008
  10. ncbi Reappraisal of a method of reconstruction after pancreatoduodenectomy
    N J Lygidakis
    Department of Surgical Oncology, Henry Dunant Hospital, Athens, Greece
    Hepatogastroenterology 52:1077-82. 2005

Research Grants

  1. Miklos Sahin-Toth; Fiscal Year: 2016
  2. PANCEATIC ELASTASE/STRUCTURAL CONTROL OF ACTIVITY
    Corey Largman; Fiscal Year: 1992

Detail Information

Publications153 found, 100 shown here

  1. ncbi The interaction of alpha-1-antitrypsin with chymotrypsin, trypsin and elastase
    A B Cohen
    Biochim Biophys Acta 391:193-200. 1975
    ..The variable susceptibility of the enzyme to blockage of the inhibition by low concentrations of p-dioxane suggested that hydrophobic bonds may be important in the interaction with alpha-1-antitrypsin...
  2. ncbi Evaluation of fecal pancreatic elastase-1 as a measure of pancreatic exocrine function in children with cystic fibrosis
    A Cade
    Regional Paediatric Cystic Fibrosis Unit, St James s University Hospital, Leeds, UK
    Pediatr Pulmonol 29:172-6. 2000
    ..The low values in the first 2 weeks in some normal and premature infants, and the persisting normal values in PS infants, make the fecal EL-1 test unsuitable for neonatal CF screening...
  3. ncbi Pancreatic elastase-1 in stools, a marker of exocrine pancreas function, correlates with both residual beta-cell secretion and metabolic control in type 1 diabetic subjects
    Franco Cavalot
    University of Turin, San Luigi Gonzaga Hospital, Department of Clinical and Biological Sciences, Diabetes Unit, 10043 Orbassano TO, Turin, Italy
    Diabetes Care 27:2052-4. 2004
  4. ncbi Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial
    Nils Ewald
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Diabetes Metab Res Rev 23:386-91. 2007
    Recently, high prevalence of exocrine dysfunction in diabetic populations has been reported. Patients with fecal elastase 1 concentration (FEC) <100 microg/g have also been demonstrated to suffer from steatorrhea in about 60% of cases, ..
  5. ncbi Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3
    Mette Vesterhus
    Department of Pediatrics, Haukeland University Hospital, Bergen, Norway
    Diabetes Care 31:306-10. 2008
    ..We wanted to investigate the prevalence of pancreatic exocrine dysfunction in patients with maturity-onset diabetes of the young type 3 (MODY3)...
  6. ncbi Fecal elastase 1 and vitamin D3 in patients with osteoporotic bone fractures
    Sacha T W Mann
    Department of Internal Medicine, Medical Clinic III and Polyclinic of the Justus Liebig University, Giessen, Germany
    Eur J Med Res 13:68-72. 2008
    ..to clarify if patients with osteoporotic bone fractures have exocrine pancreatic insufficiency, especially reduced fecal elastase 1, connected with lowered serum levels of vitamin D3 that could be relevant for predominant osteoporosis.
  7. doi Low fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus
    Jan Uwe Hahn
    Clinic for Diabetes and Metabolic Diseases, Klinikum Karlsburg, Karlsburg, Germany
    Pancreas 36:274-8. 2008
    On the basis of very low fecal elastase 1 and very high fecal fat estimations, it has been claimed that exocrine pancreatic insufficiency is frequent in diabetic patients, and that in up to 40% of the patients, pancreatic enzyme ..
  8. ncbi Comparing the urinary pancreolauryl ratio and faecal elastase-1 as indicators of pancreatic insufficiency in clinical practice
    D A Elphick
    Department of Gastroenterology, Barnsley District General Hospital, Barnsley, UK
    Pancreatology 5:196-200. 2005
    ..Both tests have previously been validated against 'gold standard' tests of pancreatic function, but their use in a clinical setting has never been directly compared...
  9. pmc Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells
    Gerald Misinzo
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    J Virol 82:1128-35. 2008
    ..These results suggest that serine protease-mediated PCV2 disassembly is enhanced in porcine epithelial cells but inhibited in monocytic cells after inhibition of endosome-lysosome system acidification...
  10. ncbi Reappraisal of a method of reconstruction after pancreatoduodenectomy
    N J Lygidakis
    Department of Surgical Oncology, Henry Dunant Hospital, Athens, Greece
    Hepatogastroenterology 52:1077-82. 2005
    ..The present study is designed to substantiate the claims of various advantages of this method of PD and reconstruction and to explain the rationale behind this method...
  11. ncbi Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA
    T S Fletcher
    Biochemistry Research Laboratory, Veterans Administration Medical Center, Martinez, California 94553
    Biochemistry 26:7256-61. 1987
    ..bounded by Gly-216 and Ser-226, making this pocket intermediate in size between chymotrypsins and elastase 1 or protease E, consistent with the substrate specificity of elastase 2 for long-chain aliphatic or aromatic amino acids...
  12. doi Validation of fecal elastase-1 determination using immunoenzymatic assay in HIV-infected patients
    Claudia Giorgia Bronzatti de Oliveira
    Faculdade de Medicina do ABC, Sao Paulo, Brazil
    J Clin Lab Anal 22:286-90. 2008
    ..424). This test is useful to diagnose pathologies related to pancreatic insufficiency...
  13. ncbi Diagnostic value of pancreatic elastase-1 in human acute pancreatitis
    Urszula Wereszczynska-Siemiatkowska
    Department of Gastroenterology, Medical University, Białystok, Poland
    Arch Immunol Ther Exp (Warsz) 51:195-200. 2003
    ..We suggest that pEla-1 has little diagnostic value and does not provide additional information to that of the less expensive and more widely available serum amylase and lipase...
  14. pmc Markers for trans-Golgi membranes and the intermediate compartment localize to induced membranes with distinct replication functions in flavivirus-infected cells
    J M MacKenzie
    Sir Albert Sakzewski Virus Research Centre, Royal Children s Hospital, Herston, Brisbane, Australia 4029
    J Virol 73:9555-67. 1999
    ..This is the first report identifying trans-Golgi membranes and the intermediate compartment as the apparent sources of the flavivirus-induced membranes involved in events of replication...
  15. ncbi Physical mapping of the human ELA1 gene between D12S361 and D12S347 on chromosome 12q13
    R L Davies
    Department of Biology, Sweet Briar College, Virginia 24595, USA
    Genomics 29:766-8. 1995
    ELA1, the pancreatic elastase 1 gene, is conserved in mammalian genomes. ELA1 was previously mapped to chromosome 12 using a panel of mouse-human somatic cell hybrids...
  16. ncbi Association between steatorrhea, growth, and immunologic status in children with perinatally acquired HIV infection
    T A Sentongo
    Division of Gastroenterology, Hepatology, and Nutrition, Children s Memorial Medical Center, 2300 Children s Plaza No 65, Chicago, IL 60614
    Arch Pediatr Adolesc Med 155:149-53. 2001
    ..To examine the prevalence of steatorrhea and exocrine pancreatic insufficiency (EPI) and their association with growth and immune status variables in children with perinatally acquired human immunodeficiency virus (HIV) infection...
  17. pmc Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y
    Richard Szmola
    Department of Molecular and Cell Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 104:11227-32. 2007
    ..in promoting trypsin degradation, because chymotrypsin B1, chymotrypsin B2, elastase 2A, elastase 3A, or elastase 3B are ineffective...
  18. ncbi Fecal elastase-1 is decreased in villous atrophy regardless of the underlying disease
    J Walkowiak
    Karol Marcinkowski University of Medical Sciences, Poznan, Poland
    Eur J Clin Invest 31:425-30. 2001
    ..E1 levels in other malabsorption conditions are unknown. Therefore, the aim of the present study was to evaluate E1 concentrations in various malabsorption syndromes...
  19. ncbi Exocrine pancreatic function in patients with end-stage renal disease
    J Griesche-Philippi
    Practice for Nephrology and Dialysis, University of Gottingen, Gottingen, Germany
    Clin Nephrol 74:457-64. 2010
    ..Our goal was therefore not only to establish the frequency but also the severity of exocrine pancreatic insufficiency in hemodialysis patients...
  20. doi Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice
    Bing Li
    Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Physiol Gastrointest Liver Physiol 299:G413-21. 2010
    ..In contrast to INGAP or Reg3beta, exocrine overexpression of Reg2 offered no protection to the endocrine or exocrine pancreas, indicating clear subtype specificities of the Reg family of proteins...
  21. ncbi Exocrine pancreatic function during the early recovery phase of acute pancreatitis
    Raffaele Pezzilli
    Department of Digestive Diseases and Internal Medicine, University of Bologna, Sant Orsola Malpighi Hospital, Bologna, Italy
    Hepatobiliary Pancreat Dis Int 8:316-9. 2009
    ..This study aimed to prospectively assess the exocrine pancreatic function in patients with acute pancreatitis at the time of their refeeding...
  22. ncbi Autolysis of proproteinase E in bovine procarboxypeptidase A ternary complex gives rise to subunit III
    R Pascual
    Departament de Bioquimica Fac Ciències, Universitat Autonoma de Barcelona, Spain
    FEBS Lett 277:37-41. 1990
    ..residues when the former is allowed to autolyze in solution or when catalytic amounts of isolated active proteinase E are added to it...
  23. pmc In vitro antiviral activity and single-dose pharmacokinetics in humans of a novel, orally bioavailable inhibitor of human rhinovirus 3C protease
    Amy K Patick
    Department of Virology, Pfizer Global Research and Development, 10777 Science Center Drive, San Diego, CA 92121, USA
    Antimicrob Agents Chemother 49:2267-75. 2005
    ..These experiments highlight Compound 1 as a potent, orally bioavailable, irreversible inhibitor of HRV 3C protease and provide data that suggest that Cmax rather than the Cmin might be the key variable predicting clinical efficacy...
  24. ncbi Further studies on the human pancreatic binary complexes involving procarboxypeptidase A
    M Moulard
    Centre de Biochimie et de Biologie Moleculaire du CNRS, Marseille, France
    FEBS Lett 261:179-83. 1990
    ..previously reported, two of these complexes associated procarboxypeptidase A to either a glycosylated truncated protease E or zymogen E...
  25. pmc Crystal structure of bovine procarboxypeptidase A-S6 subunit III, a highly structured truncated zymogen E
    D Pignol
    Laboratoire de Cristallographie et de Cristallogénès des Protéines, Institut de Biologie Structurale, Grenoble, France
    EMBO J 13:1763-71. 1994
    ..Based on the structures of subunit III and elastase 1, it is concluded that large concerted movements are necessary for the activation of zymogen E...
  26. doi Usefulness of a 13C-labeled mixed triglyceride breath test for assessing pancreatic exocrine function after pancreatic surgery
    Hiroyuki Nakamura
    Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Surgery 145:168-75. 2009
    ..We evaluated the usefulness of a (13)C-labeled mixed triglyceride breath test for assessing pancreatic exocrine function after pancreatic surgery...
  27. doi Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency
    John S Leeds
    Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Clin Gastroenterol Hepatol 8:433-8. 2010
    ..We evaluated the prevalence of exocrine pancreatic insufficiency in diarrhea-predominant IBS (D-IBS) and assessed the effects of pancreatic enzyme supplementation...
  28. doi Pancreatic fibrosis correlates with exocrine pancreatic insufficiency after pancreatoduodenectomy
    T C K Tran
    Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Dig Surg 25:311-8. 2008
    ..Obstruction of the pancreatic duct can lead to pancreatic fibrosis. We investigated the correlation between the extent of pancreatic fibrosis and the postoperative exocrine and endocrine pancreatic function...
  29. ncbi Pancreatic gene expression is altered during acute experimental pancreatitis in the rat
    J L Iovanna
    Institute National de la Sante et de la Recherche Medicale, Unité 315, Marseille, France
    Am J Physiol 261:G485-9. 1991
    ..It was concluded that induction of pancreatitis is accompanied by transcriptional and posttranscriptional modifications resulting in rapid and massive rearrangement of the pattern of pancreatic protein gene expression...
  30. ncbi Ecdysone-dependent proteolysis of an apical surface glycoprotein may play a role in imaginal disc morphogenesis in Drosophila
    C A Birr
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Development 110:239-48. 1990
    ..We discuss the possibility that gp125 is generated through the action of a hormonally controlled serine protease in a process that is necessary for disc morphogenesis...
  31. ncbi Isolation and expression in Escherichia coli of a cDNA clone encoding porcine pancreatic elastase
    Y Shirasu
    J Biochem 99:1707-12. 1986
    We have cloned a DNA that is complementary to the messenger RNA that encodes porcine pancreatic elastase 1 from pancreas using rat pancreatic elastase 1 cDNA as a probe...
  32. ncbi Faecal elastase 1: a marker of exocrine pancreatic insufficiency in cystic fibrosis
    I J Phillips
    Department of Chemical Pathology NHS, Southampton General Hospital, UK
    Ann Clin Biochem 36:739-42. 1999
    b>Pancreatic elastase 1 (E1), a digestive protease, is synthesized by the acinar cells of the pancreas. Using an enzyme-linked immunosorbent assay, we evaluated stool E1 levels in the following groups of patients...
  33. ncbi Efficacy of oral pancreatic enzyme therapy for the treatment of fat malabsorption in HIV-infected patients
    A Carroccio
    Internal Medicine, University Hospital of Palermo, via Coffaro 25, 90124 Palermo, Italy
    Aliment Pharmacol Ther 15:1619-25. 2001
    ..Nutrient malabsorption is a negative prognostic factor in acquired immunodeficiency syndrome and recent studies have shown that pancreatic insufficiency is a codetermining factor of malabsorption...
  34. ncbi Low fecal elastase-1 in type I diabetes mellitus
    A Icks
    Department of Biometrics and Epidemiology, German Diabetes Research Institute at Heinrich Heine University, Dusseldorf, Germany
    Z Gastroenterol 39:823-30. 2001
    ..Fecal elastase-1 has facilitated evaluation of pancreatic dysfunction in population-based studies...
  35. pmc Low levels of pancreatic elastase 1 in stools of preterm infants
    F Campeotto
    Service de Neonatologie, Hôf pital Cochin Saint Vincent de Paul, 82 avenue Denfert Rochereau, 75674 Paris Cedex 14, France
    Arch Dis Child Fetal Neonatal Ed 86:F198-9. 2002
    ..0007) and day 5 (164 (3-600) v 600 (158-600) microg/g, p<0.05) and correlated positively with total nutrient intake during the first week of life in preterm infants. This should probably be taken into account during early feeding...
  36. ncbi A case of inferior vena cava thrombosis and pulmonary embolism secondary to acute exacerbation of chronic pancreatitis: a rare finding in radionuclide venography
    Hitoya Ohta
    Department of Radiology, Osaka Red Cross Hospital, Japan
    Ann Nucl Med 16:147-9. 2002
    ..These findings indicated that a pancreatic cyst had penetrated into the IVC, where it triggered the formation of a thrombus and caused a pulmonary embolism. Scintigraphic examination was useful for the evaluation of this rare condition...
  37. ncbi Fecal elastase-1 as a test for pancreatic function: a review
    Roberto Dominici
    Istituto di Scienze Biomediche, Ospedale Luigi Sacco, Milano, Italy
    Clin Chem Lab Med 40:325-32. 2002
    ..It shows higher sensitivity and specificity for exocrine pancreatic insufficiency than fecal chymotrypsin determination and is comparable to oral pancreatic function tests such as the pancreolauryl test...
  38. ncbi How useful is fecal pancreatic elastase 1 as a marker of exocrine pancreatic disease?
    Satti Beharry
    Department of Pediatrics, The University of Toronto, Ontario, Canada
    J Pediatr 141:84-90. 2002
    To evaluate the role of fecal elastase 1 (E1) as a marker of exocrine pancreatic insufficiency (PI).
  39. ncbi Fecal elastase 1 measurement compared with endoscopic retrograde cholangiopancreatography for the diagnosis of chronic pancreatitis
    Philip D Hardt
    Third Medical Department, Justus Liebig University Giessen, Giessen, Germany
    Pancreas 25:e6-9. 2002
    ..Direct tests, which are claimed to be the "gold standard" of functional diagnosis, are too complicated to be performed on great numbers of patients and are not standardized...
  40. ncbi A prospective, comparative study of the para-aminobenzoic acid test and faecal elastase 1 in the assessment of exocrine pancreatic function
    S A Sonwalkar
    Department of Medicine and Gastroenterology, York Hospital, UK
    Aliment Pharmacol Ther 17:467-71. 2003
    ..Measurement of faecal elastase 1 by enzyme-linked immunoabsorbent assay is a simple, non-invasive, robust test for exocrine pancreatic insufficiency...
  41. ncbi Alterations of bone mineral density and bone metabolism in patients with various grades of chronic pancreatitis
    S T W Mann
    Department of Internal Medicine, Medical Clinic III and Polyclinic, Justus Liebig University Giessen, Giessen, Germany
    Metabolism 52:579-85. 2003
    ..bone-specific alkaline phosphatase (BAP), 1,25(OH)(2) vitamin D(3) and 25(OH) vitamin D(3), as well as fecal elastase 1 were also determined...
  42. ncbi Now that fecal elastase is available in the United States, should clinicians start using it?
    Paul G Lankisch
    Clinic of Internal Medicine, Municipal Clinic of Lueneburg, Boegelstrasse 1, D 21339 Lueneburg, Germany
    Curr Gastroenterol Rep 6:126-31. 2004
    ..The test cannot be used in non-formed stool (ie, diarrhea) unless the stool is lyophilized. All in all, this new test does not seem to be the gold standard for pancreatic function that we have been waiting for...
  43. ncbi [Experience on the pancreatic function after an episode of acute biliary oedematous pancreatitis]
    L Napolitano
    Dipartimento di Scienze chirurgiche dell Università di Chieti
    Ann Ital Chir 74:695-7. 2003
    ..In 2 patients there was also a slight impairment of the glucose metabolism. The authors suppose that the persistance of a biliary disease can affect the pancreatic function...
  44. ncbi Intraductal papillary-mucinous adenoma developed in the ventral pancreas in a patient with pancreas divisum
    Yoji Sakate
    First Department of Surgery, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, 545 8585, Osaka, Japan
    J Hepatobiliary Pancreat Surg 11:366-70. 2004
    ..Although in these three patients the tumor developed in the dorsal pancreas, the tumor developed in the ventral pancreas in our patient...
  45. ncbi Faecal pancreatic elastase--1 a non invasive measure of exocrine pancreatic function
    S D Amanquah
    Department of Chemical Pathology, University of Ghana Medical School, Accra, Ghana
    West Afr J Med 23:240-4. 2004
    ..Pancreatic elastase-1, is released into blood circulation during inflammation of the pancreas, but unlike most pancreatic enzymes it is stable during intestinal passage and not degraded...
  46. ncbi Early decline of pancreatic function in cystic fibrosis patients with class 1 or 2 CFTR mutations
    Jaroslaw Walkowiak
    Institute of Pediatrics, Department of Gastroenterology and Metabolism, Karol Marcinkowski University of Medical Sciences, 60 572 Poznan, Poland
    J Pediatr Gastroenterol Nutr 40:199-201. 2005
    ..We assessed the decline of pancreatic function in CF infants carrying class 1 or 2 CFTR mutations who were diagnosed in a neonatal screening program...
  47. ncbi Enzymatic recontouring of auricular cartilage in a rabbit model
    Phillip L Massengill
    Otolaryngology Service, Department of Surgery, Madigan Army Medical Center, Tacoma, Wash, USA
    Arch Facial Plast Surg 7:104-10. 2005
    ..To evaluate the effectiveness of contouring auricular cartilage in a rabbit model using biologically active enzymes injected subcutaneously...
  48. ncbi [Biochemical diagnostics in acute pancreatitis recognition and outcome predicition]
    Paweł Olczyk
    Katedra i Zakład Chemii Klinicznej i Diagnostyki Laboratoryjnej, Slaska Akademia Medyczna, Sosnowiec
    Przegl Lek 61:1420-7. 2004
    ..All these newly introduced biochemical methods allow to look optimistically into the future of laboratory diagnostics of the acute pancreatitis believing that the problem of diagnosing and predicting the AP severity will be solved...
  49. ncbi [Fecal elastase-1: a useful test in pediatric practice]
    L David-Henriau
    Unité de Gastroentérologie Pédiatrique, Departement de Pediatrie, Centre Hospitalier Pellegrin, CHU de Bordeaux, Place Amelie Raba Leon, 33076, Bordeaux Cedex, France
    Arch Pediatr 12:1221-5. 2005
    ..To study fecal elastase-1 (E1F) and chymotrypsin (ChT) in stools for the diagnosis of pancreatic insufficiency in pediatric practice...
  50. ncbi Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression
    Theodore H Lindsay
    Neurosystems Center, 18 208 Moos Tower, School of Dentistry, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN 55455, USA
    Pain 119:233-46. 2005
    ..Defining the mechanisms that mask this pain in early and mid-stage disease and drive the pain in late-stage disease may aid in earlier diagnosis, survival, and increased quality of life of patients with pancreatic cancer...
  51. ncbi Influence of cholesterol and fat in food on indirect parameters of exocrine pancreatic function
    J Heller
    Institute of Nutrition Science, Justus Liebig University, Giessen, Germany
    Pancreatology 6:220-3. 2006
    b>Fecal elastase 1, chymotrypsin activity, and fat content in stool are clinical parameters of exocrine pancreatic function...
  52. ncbi Correlation of MRCP quantification (MRCPQ) with conventional non-invasive pancreatic exocrine function tests
    Alice Gillams
    Medical Imaging, University College London Medical School and Hospitals, London, United Kingdom
    Abdom Imaging 33:469-73. 2008
    To correlate MRCP quantification (MRCPQ) of pancreatic fluid output following secretin with steatorrhoea, urinary pancreo-lauryl (PL) or fecal elastase 1 (FE1) tests.
  53. ncbi Exocrine pancreatic function in biliary tract pathology treated with the endoscopic methods
    J Wasielica-Berger
    Department of Gastroenterology and Internal Medicine, Medical University of Białystok, Poland
    Adv Med Sci 52:222-7. 2007
    ..The objective was to assess pancreatic exocrine function in biliary tract pathology (cholelithiasis, strictures) before and after endoscopic treatment...
  54. ncbi Exocrine pancreas disfunction in severely traumatised patients and early enteral nutrition
    Metin Senkal
    Department of General Surgery, Marien Hospital Witten, Germany
    Ulus Travma Acil Cerrahi Derg 14:34-9. 2008
    ..We investigated exocrine pancreatic insufficiency in severely traumatised patients with enteral nutrition using the fecal elastase-1 concentration...
  55. doi Evaluation of a fecal pancreatic elastase-1 enzyme-linked immunosorbent assay: Assessment versus an established assay and implication in classifying pancreatic function
    J Alan Erickson
    ARUP Laboratories, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
    Clin Chim Acta 397:87-91. 2008
    ..Disagreement continues regarding 2 fecal pancreatic elastase-1 (PE-1) ELISAs and their respective capabilities to assess pancreatic function...
  56. pmc Does an association exist between chronic pancreatitis and liver cirrhosis in alcoholic subjects?
    Luis Aparisi
    Liver Unit, Hospital Clinico Universitario, Avda Blasco Ibanez 17, Valencia 46010, Spain
    World J Gastroenterol 14:6171-9. 2008
    ..To study the possible association between chronic pancreatitis (CP) and liver cirrhosis (LC) of alcoholic etiology, after excluding any other causes...
  57. ncbi Parathormone levels and Vitamin D metabolism in female patients with various grades of fecal elastase 1 deficiency
    J Teichmann
    Department of Internal Medicine, Medical Clinc C, Ludwigshafen, Germany
    Eur J Med Res 13:563-7. 2008
    ..still too few conclusive reports about conspicuous parathormone (PTH) and Vitamin D metabolism in patients with fecal elastase 1 deficiency or any connection of the calcium metabolism to the severity of exocrine pancreas insufficiency.
  58. doi Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats
    Hajime Tanaka
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer Sci 101:341-6. 2010
    ..In marked contrast, injection of Ad-CAG-Cre resulted in pancreatic cancer development within 4 weeks. These results indicate that adult acinar cells are refractory to Ras oncogene activation and do not develop neoplasia in this model...
  59. ncbi Management of pancreatic exocrine insufficiency: Australasian Pancreatic Club recommendations
    James Toouli
    Department of Surgery, Flinders Medical Centre, Adelaide, SA, Australia
    Med J Aust 193:461-7. 2010
    ..Medium-chain triglycerides do not provide any clear nutritional advantage over long-chain triglycerides, but can be trialled in patients who fail to gain or to maintain adequate bodyweight in order to increase energy intake...
  60. doi Characterization of Escherichia coli nucleoids released by osmotic shock
    Anna S Wegner
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Kruislaan 316, 1098 SM Amsterdam, The Netherlands
    J Struct Biol 178:260-9. 2012
    ..Lysozyme at concentrations above 1 μg/ml in the lysate compacted the nucleoids. Treatment with protease E or K (20-200 μg/ml) and sodium dodecyl sulfate (SDS; 0.001-0...
  61. doi Faecal elastase-1 is an independent predictor of survival in advanced pancreatic cancer
    Stefano Partelli
    Department of Surgery, University of Verona, Policlinico GB Rossi, Verona, Italy
    Dig Liver Dis 44:945-51. 2012
    ..The relationship between prognosis of advanced pancreatic cancer and exocrine secretion impairment is unknown...
  62. doi Exocrine pancreatic insufficiency following esophagectomy
    J R Huddy
    Regional Oesophagogastric Unit, Royal Surrey County Hospital, Guildford, Surrey, UK
    Dis Esophagus 26:594-7. 2013
    ..In patients with proven EPI or those who are symptomatic with mild EPI, a trial of PERT should be offered and symptoms reassessed...
  63. doi Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection
    Luigi Benini
    Gastroenterology Unit, Department of Medicine, University of Verona, Policlinico G B Rossi, Piazzale Scuro 10, 37134 Verona, Italy
    Pancreatology 13:38-42. 2013
    ....
  64. doi Pancreatic remnant fate
    S Hac
    Department of General Endocrine and Transplant Surgery, Medical University of Gdansk, Poland
    Folia Morphol (Warsz) 74:56-60. 2015
    ..There was no correlation of pancreatic exo- or endocrine insufficiency with the volume of pancreatic remnant or the kind of surgery or anastomosis performed. ..
  65. doi Romanian guidelines on the diagnosis and treatment of exocrine pancreatic insufficiency
    Cristian Gheorghe
    Carol Davila University of Medicine and Pharmacy Fundeni Clinical Institute, Bucharest, Romania
    J Gastrointestin Liver Dis 24:117-23. 2015
    ..It is also indicated in patients with celiac disease, who have chronic diarrhea (in spite of gluten-free diet), and in patients with cystic fibrosis with proven EPI. ..
  66. doi Inverse association of HbA1c with faecal elastase 1 in people without diabetes
    Wolfgang Rathmann
    Institute for Biometrics and Epidemiology, German Diabetes Center, Dusseldorf, Germany Electronic address
    Pancreatology 15:620-5. 2015
    ..Faecal elastase 1 (FE1) was inversely correlated with diabetes duration and HbA1c in type 2 diabetes. The association of FE1 and HbA1c has not been investigated in people without diabetes...
  67. pmc The levels of serine proteases in colon tissue interstitial fluid and serum serve as an indicator of colorectal cancer progression
    Yingying Xie
    CAS Key Laboratory of Genome Sciences and Information, China Gastrointestinal Cancer Research Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China
    Oncotarget 7:32592-606. 2016
    ..0% sensitivity and 80.0% specificity. Thus, the quantitative target analysis demonstrated that some serine proteases are indicative of CRC progression. ..
  68. ncbi Gastrodia elata Blume Extract Modulates Antioxidant Activity and Ultraviolet A-Irradiated Skin Aging in Human Dermal Fibroblast Cells
    Eunju Song
    1 Department of Food and Nutrition, College of Natural Sciences, Myongji University, Yongin, Korea
    J Med Food 19:1057-1064. 2016
    ..Collectively, these results suggest that GEB has sufficient antioxidant ability to prevent the signs of skin aging in UVA-irradiated human skin cells, suggesting its potential as a natural antiaging product...
  69. ncbi Vitamin D3 in patients with various grades of chronic pancreatitis, according to morphological and functional criteria of the pancreas
    S T W Mann
    Department of Internal Medicine, Medical Clinic III and Polyclinic of the Justus Liebig University Giessen, Germany
    Dig Dis Sci 48:533-8. 2003
    ..inflammatory pancreas destruction (Cambridge classification), exocrine insufficiency (fecal elastase 1), and perhaps even the characteristics of sterol-binding of pancreatic elastase 1, which seems to be relevant for vitamin D supply.
  70. pmc Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen
    Andras Szabo
    Department of Molecular and Cell Biology, Boston University Henry M Goldman School of Dental Medicine, Boston, MA 02118, USA
    FEBS J 279:4283-92. 2012
    ..highly specific, and other human pancreatic chymotrypsins (CTRB1, CTRB2 and CTRL1) and elastases (ELA2A, ELA3A and ELA3B) do not catalyze this reaction...
  71. ncbi Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase
    N K Honey
    Somat Cell Mol Genet 10:369-76. 1984
    ..TRY1 was assigned to human chromosome 7q22----qter, CTRB to chromosome 16, and ELA1 to chromosome 12. Although the three genes are members of the same gene family, they are dispersed over different chromosomes...
  72. ncbi Prt-4 and Prt-5: new constituents of a gene cluster on chromosome 7 coding for esterproteases in the submandibular gland of the house mouse (Mus musculus)
    J Otto
    Biochem Genet 19:431-44. 1981
    ..for two different enzymes with esterproteolytic activity from mouse submandibular gland: protease A and protease E. Based upon strain distribution and biochemical properties of the two esterproteases, the existence of two ..
  73. ncbi Fecal elastase-1 determination: 'gold standard' of indirect pancreatic function tests?
    S Luth
    Dept of Medicine II Gastroenterology Hepatology, University Hospital of Heidelberg at Mannheim, Germany
    Scand J Gastroenterol 36:1092-9. 2001
    ..The aim of our study was to re-evaluate the sensitivity and specificity of elastase-1 and chymotrypsin in stool in the assessment of exocrine pancreatic insufficiency...
  74. ncbi [Fecal elastase-1 test: clinical evaluation of a new noninvasive pancreatic function test]
    Masahiro Takeda
    Central Clinical Laboratories, Tokyo Women s Medical University, Tokyo 162 8666
    Rinsho Byori 50:893-8. 2002
    ..We evaluated clinical significance of fecal elastase-1(FE-1) in patients with pancreatic diseases and pancreatic dysfunction, in comparison with other tubeless test and secretin test...
  75. ncbi Display and release of the Plasmodium falciparum circumsporozoite protein using the autotransporter MisL of Salmonella enterica
    Patricia Ruiz-Olvera
    Unidad de Investigación Médica en Inmunología e Infectología, Hospital de Infectología Dr Daniel Méndez Hernández, Centro Medico La Raza, IMSS, D F, Mexico
    Plasmid 50:12-27. 2003
    ..These results demonstrate that MisL may be used for the autodisplay and release of passenger proteins in attenuated Salmonella or E. coli strains, which may have several applications in vaccine design...
  76. ncbi High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: a prospective multicenter study
    Philip D Hardt
    Third Medical Department and Policlinic, Giessen University Hospital, Giessen, Germany
    Dig Dis Sci 48:1688-92. 2003
    ..fecal fat excretion in patients with type 1 or type 2 diabetes mellitus and exocrine dysfunction according to fecal elastase 1 concentrations <100 microg/g was investigated...
  77. ncbi Screening for pancreatic exocrine insufficiency in patients with diabetes mellitus
    Amadeu C R Nunes
    Department of Gastroenterology, University Hospitals of Coimbra, Avenida Urbano Duarte, Quinta da Estrela, Lote 7, 6o B, Coimbra, Portugal
    Am J Gastroenterol 98:2672-5. 2003
    b>Fecal elastase 1 (E1) is a relatively sensitive and specific indirect test of pancreatic exocrine function...
  78. ncbi Evaluation of serum values of pancreatic enzymes after endoscopic retrograde pancreatography in dogs
    Thomas Spillmann
    Department of Small Animal Internal Medicine at the Medical and Forensic Veterinary Clinic I, Justus Liebig University Giessen, Frankfurter Strasse 126, 35392 Giessen, Germany
    Am J Vet Res 65:616-9. 2004
    ..pancreatography (ERP) in dogs by performing repeated clinical examinations and laboratory analyses of serum amylase, lipase, canine trypsin-like immunoreactivity (cTLI), and canine pancreatic elastase 1 (cE1) after the procedure.
  79. ncbi A new fecal elastase 1 test using polyclonal antibodies for the detection of exocrine pancreatic insufficiency
    Jan Uwe Hahn
    Pancreas 30:189-91. 2005
  80. ncbi Pancreatic elastase-1 in stools, a marker of exocrine pancreas function, correlates with both residual beta-cell secretion and metabolic control in type 1 diabetic subjects: response to Mueller et al
    Franco Cavalot
    Diabetes Care 28:2810-1. 2005
  81. ncbi Evaluating the role of serum elastase 1 in the diagnosis of pancreatic cancer
    Dong Wu
    Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    Chin J Dig Dis 7:117-20. 2006
    ..To determine the normal value of serum elastase 1 in Chinese adults and evaluate its diagnostic value for pancreatic cancer...
  82. ncbi [The role of fecal elastase-1 in pancreatic diseases]
    Xiao Ou Yang
    Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Nei Ke Za Zhi 45:285-8. 2006
    ....
  83. doi Comparison of fecal elastase-1 and pancreatic function testing in children
    Prateek D Wali
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA, USA
    J Pediatr Gastroenterol Nutr 54:277-80. 2012
    ..We aimed to evaluate the performance of the FE-1 test compared with the direct pancreatic function test (PFT) with secretin stimulation in children...
  84. doi Pancreatic exocrine function in patients with diabetes
    E Larger
    Laboratoire de Coprologie, Hôtpital de la Pitié Salpétrière, APHP, Paris, France
    Diabet Med 29:1047-54. 2012
    ..Decreased function of the exocrine pancreas is frequent in patients with diabetes. Our aim was to investigate clinical correlates of pancreatic exocrine failure in patients with diabetes...
  85. doi Protracted maturation of pancreatic-specific elastase 1 excretion in preterm infants of extremely low gestational age
    Annette Münch
    Department of Neonatology, Charite University Medical Center, Berlin, Germany
    J Pediatr Gastroenterol Nutr 56:532-6. 2013
    ..The aim of the present study was to better understand the exocrine pancreatic function of extremely preterm infants...
  86. pmc Quantification of pancreatic exocrine function of chronic pancreatitis with secretin-enhanced MRCP
    Yun Bian
    Yun Bian, Li Wang, Chao Chen, Jian Ping Lu, Jia Bao Fan, Shi Yue Chen, Bing Hui Zhao, Department of Radiology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China
    World J Gastroenterol 19:7177-82. 2013
    ....
  87. ncbi Significance of increased serum elastase 1 level during the hyperosmolar hyperglycemic non-ketotic syndrome
    S Umeki
    Department of Medicine, Kawasaki Medical School, Okayama, Japan
    Hepatogastroenterology 34:212-4. 1987
    ..Rehydration therapy with half-normal saline solution immediately produced negative urine glucose, but the serum elastase 1 level only gradually normalized after improvement of HHNS...
  88. ncbi Effects of elastase-induced emphysema on airway responsiveness to methacholine in rats
    S Bellofiore
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Appl Physiol (1985) 66:606-12. 1989
    ..56 ml (+/- 0.08 ml) significantly reduced RL at 64 mg MCh/ml from 0.62 +/- 0.05 cmH2O.ml-1.s to 0.50 +/- 0.03, P less than 0.05.(ABSTRACT TRUNCATED AT 250 WORDS)..
  89. ncbi Generation of a subunit III-like protein by autolysis of human and porcine proproteinase e in a binary complex with procarboxypeptidase A
    F X Aviles
    Departament de Bioquimica í Biologia Molecular Facultat de Ciències, Universitat Autonoma de Barcelona, Spain
    Biochem Biophys Res Commun 163:1191-6. 1989
    ..treatment of human and porcine proproteinase E, procarboxypeptidase A binary complexes gave rise to active proteinase E after removal of an 11-residue N-terminal activation peptide...
  90. ncbi Substitution of valine for glycine-558 in the congenital dysthrombin thrombin Quick II alters primary substrate specificity
    R A Henriksen
    Department of Biochemistry, University of Vermont, Burlington 05405
    Biochemistry 28:2078-82. 1989
    ..These results and those of other investigators studying mutant trypsins support the conclusion that the catalytic activity of serine proteases is very sensitive to structural alterations in the primary substrate binding pocket...
  91. pmc Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas
    M Cockell
    Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland
    Mol Cell Biol 9:2464-76. 1989
    ..The observation that PTF 1 bound to DNA sequences that have been defined as transcriptional enhancers by others suggests that this factor is involved in the coordinate expression of genes transcribed in the acinar pancreas...
  92. ncbi Molecular cloning of complementary DNA for human medullasin: an inflammatory serine protease in bone marrow cells
    K Okano
    Basic Research Laboratories, Toray Industries, Inc, Kanagawa
    J Biochem 102:13-6. 1987
    ..The deduced amino acid sequence of medullasin shows a typical serine protease structure, with 41% homology with pig elastase 1...
  93. ncbi Noncatalytic protein component of elastase from horse leucocytes. A protein with regulatory function
    J Potempa
    Institute of Molecular Biology, Jagiellonian University, Cracow, Poland
    Int J Biochem 20:105-8. 1988
    ..3. A possible regulatory role of this protein may be inferred from a higher affinity of elastase 1 to NPC rather than to elastin...
  94. ncbi Interaction between human pancreatic elastase and plasma protease inhibitors
    E L Gustavsson
    Hoppe Seylers Z Physiol Chem 361:169-76. 1980
    ..The elastase bound by alpha 2-macroglobulin retains its activity against low molecular weight substrates, while that bound by alpha 1-antitrypsin is enzymologically inactive...
  95. ncbi Correlation between male fertility and acrosin-like protease activity in rats treated with Spartium junceum
    J S Chen
    Centro Studio Cellule Germinali del CNR, University of Siena, Italy
    Zygote 1:309-13. 1993
    ..The implications of this finding is discussed although the exact molecular basis of the phenomenon is uncertain...
  96. pmc Pharmacological activities of TEI-8362, a novel inhibitor of human neutrophil elastase
    H Mitsuhashi
    Teijin Institute for Bio Medical Research, Hino, Tokyo, Japan
    Br J Pharmacol 126:1147-52. 1999
    ..t., i.v., or inhalant administration of TEI-8362. 5. These pharmacological actions of TEI-8362 suggest that this drug has therapeutic value in the treatment of destructive lung diseases due to neutrophils...
  97. ncbi Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism
    U Talas
    Center for Cutaneous Research, St Bartholomew s and the Royal London School of Medicine and Dentistry, Whitechapel, London, UK
    J Invest Dermatol 114:165-70. 2000
    Human pancreatic elastase 1 is a serine protease which maps to the chromosomal region 12q13 close to a locus for an autosomal dominant skin disease, diffuse nonepidermolytic palmoplantar keratoderma, and was investigated as a possible ..
  98. ncbi Behaviour of serum pancreatic enzymes in chronic pancreatitis
    R Pezzilli
    Emergency Department, Sant Orsola Hospital, Bologna, Italy
    Dig Liver Dis 32:233-7. 2000
    ..To establish whether serum pancreatic enzyme determination is useful in the identification of patients with chronic pancreatitis and in revealing the presence of exocrine pancreatic insufficiency..
  99. ncbi Pancreatic function tests: when to choose, what to use
    W G Boeck
    Department of Internal Medicine I, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
    Curr Gastroenterol Rep 3:95-100. 2001
    ..Nevertheless, all indirect tests are of limited value in patients with mild to moderate impairment of pancreatic function. In these patients, the secretin-caerulein test remains the gold standard...
  100. ncbi Fecal pancreatic elastase 1 in the work up of patients with chronic diarrhea
    G Masoero
    Department of Gastroenterology, Mauriziano Hospital, Torino, Italy
    Int J Pancreatol 28:175-9. 2000
    ..Quantitative determination of pancreatic elastase-1 (E1) in stools has been proposed as a novel, noninvasive test of pancreatic function. The aim of the study was to verify its role in the differential diagnosis of chronic diarrhea...
  101. ncbi Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas
    R S Heller
    Department of Developmental Biology, Hagedorn Research Institute, DK 2820, Gentofte, Denmark
    Diabetes 50:1553-61. 2001
    ..The mechanisms underlying these observations remain to be elucidated...

Research Grants3

  1. Miklos Sahin-Toth; Fiscal Year: 2016
    ..In humans, there are five pancreatic elastase genes (ELA1, ELA2A, ELA2B, ELA3A, and ELA3B) which give rise to three functional elastases (ELA2A, ELA3A and ELA3B)...
  2. PANCEATIC ELASTASE/STRUCTURAL CONTROL OF ACTIVITY
    Corey Largman; Fiscal Year: 1992
    ..In the most recent funding period, we have cloned both of the major pancreatic elastase-like molecules: protease E and elastase 2. We have recently determined the complete nucleic acid sequence for each cDNA...