CEL

Summary

Gene Symbol: CEL
Description: carboxyl ester lipase
Alias: BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8, bile salt-activated lipase, bile salt-dependent lipase, oncofetal isoform, bucelipase, carboxyl ester hydrolase, carboxyl ester lipase (bile salt-stimulated lipase), cholesterol esterase, fetoacinar pancreatic protein, lysophospholipase, pancreatic, sterol esterase
Species: human

Top Publications

  1. ncbi Liver receptor homolog 1 controls the expression of carboxyl ester lipase
    Elisabeth Fayard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM Universite Louis Pasteur, B P 10142, F 67404 Illkirch, C U de Strasbourg, France
    J Biol Chem 278:35725-31. 2003
  2. pmc Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2
    Sara H M Bengtsson
    Department of CMB Molecular Biology, Box 462, S 405 30 Goteborg, Sweden
    Biochem J 365:481-8. 2002
  3. pmc HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism
    Martijn J Stax
    Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e32534. 2012
  4. ncbi Isolation and characterization of human milk bile salt-activated lipase C-tail fragment
    C S Wang
    Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Biochemistry 34:10639-44. 1995
  5. ncbi Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction
    Helge Raeder
    Section for Pediatrics, Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Nat Genet 38:54-62. 2006
  6. pmc Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells
    Marloes A Naarding
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Antimicrob Agents Chemother 50:3367-74. 2006
  7. pmc Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans
    Laurence Panicot-Dubois
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 117:3708-19. 2007
  8. pmc Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism
    Martijn J Stax
    Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e17316. 2011
  9. pmc Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease
    Bente B Johansson
    Department of Clinical Medicine, University of Bergen, N 5020 Bergen, Norway
    J Biol Chem 286:34593-605. 2011
  10. doi Severe pancreatic dysfunction but compensated nutritional status in monogenic pancreatic disease caused by carboxyl-ester lipase mutations
    Erling Tjora
    From the Department of Clinical Medicine, University of Bergen Departments of Pediatrics, Radiology, Medicine, and Voss Hospital, Haukeland University Hospital Section for Pathology, The Gade Institute, University of Bergen Department of Pathology, Haukeland University Hospital and Section for Radiology, Department of Surgical Sciences, University of Bergen, Bergen, Norway
    Pancreas 42:1078-84. 2013

Research Grants

  1. Dean Sheppard; Fiscal Year: 2016
  2. Aric L Gregson; Fiscal Year: 2015
  3. Robert J Blount; Fiscal Year: 2014
  4. Richard F Silver; Fiscal Year: 2016
  5. Benjamin D Medoff; Fiscal Year: 2016
  6. Dorothy S Cheung; Fiscal Year: 2014
  7. Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes
    Mary Jane Thomassen; Fiscal Year: 2013
  8. Longitudinal Studies of HIV-Associated Bacterial Pneumonia
    William N Rom; Fiscal Year: 2013
  9. John K McGuire; Fiscal Year: 2014
  10. HIGH-DOSE VITAMIN D AND ANTIMICROBIAL PEPTIDE EXPRESSION IN LUNG FAILURE
    Thomas R Ziegler; Fiscal Year: 2012

Detail Information

Publications452 found, 100 shown here

  1. ncbi Liver receptor homolog 1 controls the expression of carboxyl ester lipase
    Elisabeth Fayard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM Universite Louis Pasteur, B P 10142, F 67404 Illkirch, C U de Strasbourg, France
    J Biol Chem 278:35725-31. 2003
    ..Herein, we describe the identification of carboxyl ester lipase (CEL) as a novel target of LRH-1 in pancreas, a tissue in which LRH-1 is abundantly expressed...
  2. pmc Transcriptional regulation of the human carboxyl ester lipase gene in THP-1 monocytes: an E-box required for activation binds upstream stimulatory factors 1 and 2
    Sara H M Bengtsson
    Department of CMB Molecular Biology, Box 462, S 405 30 Goteborg, Sweden
    Biochem J 365:481-8. 2002
    ..We have used the CEL-expressing human monocytic cell line THP-1 to investigate the transcriptional regulation of the human CEL in monocytes...
  3. pmc HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism
    Martijn J Stax
    Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e32534. 2012
    DC-SIGN expressed by dendritic cells captures HIV-1 resulting in trans-infection of CD4(+) T-lymphocytes. However, BSSL (bile-salt stimulated lipase) binding to DC-SIGN interferes with HIV-1 capture...
  4. ncbi Isolation and characterization of human milk bile salt-activated lipase C-tail fragment
    C S Wang
    Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Biochemistry 34:10639-44. 1995
    ..in the proline-rich, mucin-like, C-terminal region (C-tail) of human milk bile salt-activated lipase (BAL) were studied in order to assess the possible physiological functions of this region...
  5. ncbi Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction
    Helge Raeder
    Section for Pediatrics, Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Nat Genet 38:54-62. 2006
    ..of the young identified Family 2, with another single-base deletion in CEL and a similar phenotype with beta-cell failure and pancreatic exocrine disease...
  6. pmc Bile salt-stimulated lipase from human milk binds DC-SIGN and inhibits human immunodeficiency virus type 1 transfer to CD4+ T cells
    Marloes A Naarding
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Antimicrob Agents Chemother 50:3367-74. 2006
    ..blotting, and matrix-assisted laser desorption ionization analysis, we identified bile salt-stimulated lipase (BSSL), a Lewis X (LeX)-containing glycoprotein found in human milk, to be the major variant protein between the samples...
  7. pmc Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans
    Laurence Panicot-Dubois
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 117:3708-19. 2007
    Bile salt-dependent lipase (BSDL) is an enzyme involved in the duodenal hydrolysis and absorption of cholesteryl esters. Although some BSDL is transported to blood, the role of circulating BSDL is unknown...
  8. pmc Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism
    Martijn J Stax
    Laboratory of Experimental Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 6:e17316. 2011
    ..Bile salt-stimulated lipase (BSSL) from human milk potently binds DC-SIGN and blocks DC-SIGN mediated trans-infection of CD4(+) T-lymphocytes with ..
  9. pmc Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease
    Bente B Johansson
    Department of Clinical Medicine, University of Bergen, N 5020 Bergen, Norway
    J Biol Chem 286:34593-605. 2011
    ..with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL)...
  10. doi Severe pancreatic dysfunction but compensated nutritional status in monogenic pancreatic disease caused by carboxyl-ester lipase mutations
    Erling Tjora
    From the Department of Clinical Medicine, University of Bergen Departments of Pediatrics, Radiology, Medicine, and Voss Hospital, Haukeland University Hospital Section for Pathology, The Gade Institute, University of Bergen Department of Pathology, Haukeland University Hospital and Section for Radiology, Department of Surgical Sciences, University of Bergen, Bergen, Norway
    Pancreas 42:1078-84. 2013
    ..Carboxyl-ester lipase-maturity-onset diabetes in the young (CEL-MODY) is a monogenic, highly penetrant and progressive pancreatic disease with no known primary extrapancreatic ..
  11. ncbi Genomic organization, sequence analysis, and chromosomal localization of the human carboxyl ester lipase (CEL) gene and a CEL-like (CELL) gene
    U Lidberg
    Department of Molecular Biology, University of Goteborg, Sweden
    Genomics 13:630-40. 1992
    ..The organization of the human CEL gene is similar to that of the recently reported rat pancreatic cholesterol esterase gene...
  12. ncbi Modified low density lipoprotein enhances the secretion of bile salt-stimulated cholesterol esterase by human monocyte-macrophages. species-specific difference in macrophage cholesteryl ester hydrolase
    F Li
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0529, USA
    J Biol Chem 272:28666-71. 1997
    ..Oligonucleotide primers for bile salt-stimulated cholesterol esterase yielded positive reactions with RNA isolated from human peripheral blood monocytes, monocyte-derived ..
  13. ncbi Molecular cloning of the oncofetal isoform of the human pancreatic bile salt-dependent lipase
    E Pasqualini
    INSERM U260, Faculte de Medecine Timone, 27 Blv Jean Moulin, 13385 Marseille, France
    J Biol Chem 273:28208-18. 1998
    ..a 100-kDa glycoprotein secreted by the human pancreas, were immunodetected in BxPC-3 and SOJ-6 pancreatic tumoral cell lines...
  14. pmc Bile-salt-stimulated lipase and mucins from milk of 'secretor' mothers inhibit the binding of Norwalk virus capsids to their carbohydrate ligands
    Nathalie Ruvoën-Clouet
    INSERM U601, Institute of Biology, 9 quai Moncousu, 44093 Nantes Cedex 01, France
    Biochem J 393:627-34. 2006
    ..The first fraction corresponded to BSSL (bile-salt-stimulated lipase) and the second to associated mucins MUC1 and MUC4...
  15. ncbi [Treatment of multidrug resistance in oncology and hematology]
    M Petrini
    U.O. Ematologia, , Italy
    Tumori 83:S17-20. 1997
    ..that acts as an energy-dependent pump removing possible toxic agents, including antiblastic drugs, from the cell. High levels of the mdr1 expression have been found in normal adrenal gland, kidney, colon, jejunum and liver, ..
  16. ncbi A systematic overview of chemotherapy effects in non-small cell lung cancer
    S Sorenson
    Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway
    Acta Oncol 40:327-39. 2001
    ..This overview of the literature on chemotherapy for non-small cell lung cancer (NSCLC) is based on 53 scientific publications including six meta-analyses based on 65 prospective ..
  17. pmc Bile salt-stimulated lipase in the milk of Fulani and Kanuri women in Nigeria and native Nepalese women
    J E Torres
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque 87131, USA
    J Natl Med Assoc 93:201-7. 2001
    ..with several physiologically important proteins not found in cow's milk, including bile salt-stimulated lipase (BSSL) that compensates for the reduced lipolytic capability of the newborn intestine...
  18. ncbi Basic and therapeutic trial results obtained in the spontaneous AK leukemia (lymphoma) model-end of 1971
    H E Skipper
    Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, AL, USA
    Cancer Chemother Rep 56:273-87, 289-314. 1972
    ..6 day). In general, the cytokinetic parameters of advanced spontaneous AK lymphoma cell populations are more like those observed in advanced human leukemias than are those of early L1210 leukemia...
  19. ncbi Differences in the glycosylation of recombinant and native human milk bile salt-stimulated lipase revealed by peptide mapping
    M Strömqvist
    ASTRA HASSLE AB, Umea, Sweden
    J Chromatogr A 718:53-8. 1995
    The milk of some mammals contains a bile salt-stimulated lipase (BSSL)...
  20. ncbi A systematic overview of chemotherapy effects in B-cell chronic lymphocytic leukaemia
    E Kimby
    Department of Haematology, University Hospital, Huddinge, Sweden
    Acta Oncol 40:224-30. 2001
    ..This synthesis of the literature on chemotherapy for B-cell chronic lymphocytic leukaemia (B-CLL) is based on data from 20 randomised controlled trials and one meta-analysis...
  21. ncbi An apocrine membrane antigen with polarized distribution and hormonally regulated expression in human endometrial and mammary carcinoma cell lines
    L M Forsman
    Department of Pathology, University of Helsinki, Finland
    Acta Pathol Microbiol Immunol Scand A 95:315-23. 1987
    ..of an apocrine epithelial differentiation antigen (AEA) were studied in one endometrial adenocarcinoma cell line (HEC-1-B) and two mammary carcinoma cell lines (MCF-7 and T47-D), using an antiserum raised against ..
  22. ncbi Oxidative injury induces influx-dependent changes in intracellular calcium homeostasis
    J D Swann
    Department of Pathology, School of Medicine, University of Maryland, Baltimore 21201
    Toxicol Pathol 19:128-37. 1991
    Understanding of the mechanisms of cell injury and cell death is fundamental to the understanding of both protection against and initiation of cell injury and cell death...
  23. ncbi Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells
    N M Kumar
    Department of Internal Medicine, SUNY at Buffalo School of Medicine, Buffalo General Hospital 14203, USA
    Exp Cell Res 221:385-94. 1995
    The transforming growth factors-beta (TGFs-beta) family of genes plays important roles in cell growth and differentiation in many cell types...
  24. ncbi Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer
    J W Simons
    Johns Hopkins Oncology Center, Brady Urological Institute, and Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 59:5160-8. 1999
    ..vaccine cells was successful to meet trial specifications in 8 of 11 cases (73%); the yields of the primary culture cell limited the number of courses of vaccination...
  25. ncbi Role of apoptosis in biology and pathology: resistance to apoptosis in colon carcinogenesis
    C M Payne
    Arizona Research Laboratories, University of Arizona, Tucson 85724, USA
    Ultrastruct Pathol 19:221-48. 1995
    The overview of apoptosis presented here emphasizes cell deletion in the immune system, with particular reference to T- and B-lymphocyte development, and the in vivo and in vitro senescence of human neutrophils...
  26. ncbi Transcription factors contributing to the pancreatic beta-cell phenotype
    O D Madsen
    Department of Developmental Biology, Hagedorn Research Institute, Gentofte, Denmark
    Horm Metab Res 29:265-70. 1997
    ..renamed to pancreatic-duodenal homeobox factor-1, PDX1) was originally cloned and characterized as an islet beta-cell specific insulin gene transcription factor (1) and later shown to be essential for the formation of the mature ..
  27. ncbi Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent
    W W Li
    Laboratories of Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 7:2908-11. 2001
    ..anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (STS) cell lines...
  28. ncbi Adhesion molecules and their role in vascular disease
    C F Krieglstein
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, USA
    Am J Hypertens 14:44S-54S. 2001
    A variety of recently discovered glycoproteins have been implicated in cell-cell interactions that are critical for normal hemostasis, immune surveillance, and vascular wall integrity...
  29. pmc Study of mechanisms of electric field-induced DNA transfection. V. Effects of DNA topology on surface binding, cell uptake, expression, and integration into host chromosomes of DNA in the mammalian cell
    T D Xie
    Department of Biochemistry, University of Minnesota College of Biological Sciences, St Paul 55108
    Biophys J 65:1684-9. 1993
    ..Our results indicate that cell surface binding and PEF-induced cell uptake of DNA did not depend on the topology of DNA...
  30. pmc The pathobiology of the human enterochromaffin-like cell
    I M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut
    Yale J Biol Med 65:775-92; discussion 827-9. 1992
    The significance of the enterochromaffin-like (ECL) cell as a critical endocrine regulator of gastric fundic mucosal function has only recently been recognized...
  31. ncbi Role of endoplasmic reticulum-derived vesicles in the formation of Golgi elements in sec23 and sec18 Saccharomyces Cerevisiae mutants
    M N Morin Ganet
    , CEA Saclay, France
    Anat Rec 251:256-64. 1998
    ..To follow the modifications of cell organelles, cell sections were selected at random in thinner sections and cell organelles were scored...
  32. ncbi Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study
    J C Lotz
    Department of Orthopaedic Surgery, University of California, San Francisco, California, USA
    Spine (Phila Pa 1976) 23:2493-506. 1998
    ..Alterations in hydration and stress have been associated with changes in disc cell activity in vitro and in other collagenous tissues in vivo...
  33. ncbi A site-directed approach for constructing temperature-sensitive ubiquitin-conjugating enzymes reveals a cell cycle function and growth function for RAD6
    K S Ellison
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    J Biol Chem 266:24116-20. 1991
    We have determined the gene sequence of a temperature-sensitive allele of the cell cycle-related ubiquitin-conjugating enzyme CDC34 (UBC 3) from Saccharomyces cerevisiae...
  34. ncbi Functional comparison of the yeast scERV1 and scERV2 genes
    G Stein
    Botanisches Institut, , Germany
    Yeast 14:171-80. 1998
    ..Its gene product is essential for the yeast cell and is involved in the biogenesis of mitochondria and the regulation of the cell cycle...
  35. ncbi Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at beta-cells
    W Kramer
    Hoechst AG, Frankfurt, Germany
    Horm Metab Res 28:464-8. 1996
    Glimepiride was compared with glibenclamide for its insulin secretion stimulating and beta-cell membrane depolarizing activity as well as for its binding kinetics to beta-cell membranes and for its beta-cell membrane binding proteins...
  36. ncbi Development and characterization of a rapid-onset rodent inhalation model of asbestosis for disease prevention
    B T Mossman
    Department of Pathology, University of Vermont, Burlington
    Toxicol Pathol 19:412-8. 1991
    ..Total and differential cell counts were performed on cell pellets from BAL...
  37. ncbi Identification of the location, extent, and pathway of sensory neurologic feedback after mechanical stimulation of a lateral spinal ligament in chickens
    H Jiang
    Department of Surgery, University of Alberta, Edmonton, Canada
    Spine (Phila Pa 1976) 22:17-25. 1997
    ..The pathway was traced by locating the sites of Fos protein production in neuronal cell bodies at various sites in the nervous system...
  38. ncbi Hepatocyte growth factor/scatter factor in the eye
    I Grierson
    Unit of Ophthalmology, Department of Medicine, University of Liverpool, Duncan Building, L69 3GA, Liverpool, UK
    Prog Retin Eye Res 19:779-802. 2000
    ..However, there is growing evidence for the existence of autocrine loops in a number of cell systems prominent among which are ocular cells such as the corneal endothelium, the lens epithelium, the retinal ..
  39. ncbi Characterization of a renal epithelial cell model of apoptosis using okadaic acid and the NRK-52E cell line
    M A Davis
    Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA
    Toxicol Pathol 22:595-605. 1994
    Apoptotic cell death plays an important role in the pathogenesis of renal tubular epithelial damage and repair following tubular injury. Presently, the cellular factors involved in regulating apoptotic pathways in the kidney are unknown...
  40. ncbi Biliary proliferation and adaptation in furan-induced rat liver injury and carcinogenesis
    A E Sirica
    Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0297, USA
    Toxicol Pathol 24:90-9. 1996
    ..arose at 70-100% incidences from right/caudate liver lobes and which were characterized by small intestine mucosal cell differentiation...
  41. ncbi Prevalence, morphology, and topography of blood vessels in herniated disc tissue. A comparative immunocytochemical study
    J Virri
    Spine Research Unit, Helsinki University Central Hospital, Finland
    Spine (Phila Pa 1976) 21:1856-63. 1996
    ..Ninety disc herniations removed during surgery were studied by immunocytochemistry, using two different endothelial cell markers, to study the prevalence, morphology, and topography of blood vessels in disc herniations...
  42. ncbi SF-1 (steroidogenic factor-1), C/EBPbeta (CCAAT/enhancer binding protein), and ubiquitous transcription factors NF1 (nuclear factor 1) and Sp1 (selective promoter factor 1) are required for regulation of the mouse aldose reductase-like gene (AKR1B7) expre
    C Aigueperse
    , , , France
    Mol Endocrinol 15:93-111. 2001
    ..In adrenocortical cell cultures, hormonal regulation of MVDP gene occurs through the cAMP pathway...
  43. ncbi The pathways of cell death: oncosis, apoptosis, and necrosis
    B F Trump
    Department of Pathology, University of Maryland School of Medicine, Baltimore 21201, USA
    Toxicol Pathol 25:82-8. 1997
    The pathways and identification of cell injury and cell death are of key importance to the practice of diagnostic and research toxicologic pathology. Following a lethal injury, cellular reactions are initially reversible...
  44. ncbi Characterization of apoptosis in a motor neuron cell line
    I V Smirnova
    Department of Veterans Affairs Medical Center, Kansas City, Missouri, USA
    Spine (Phila Pa 1976) 23:151-8. 1998
    STUDY DESIGN: Serum withdrawal was introduced to a spinal cord motor neuron cell line to investigate the mode of cell death...
  45. ncbi [Differential cytology of bronchoalveolar lavage fluid in healthy children in comparison with children colonized by lung-specific pathogens]
    P Ahrens
    Zentrum der Kinderheilkunde, , Frankfurt/Main
    Pneumologie 51:99-103. 1997
    ..BAL) was performed on 21 healthy children in order to enable quantification and characterization of the alveolar cell populations...
  46. pmc Caffeine-evoked, calcium-sensitive membrane currents in rabbit aortic endothelial cells
    J Rusko
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, FL 33101, USA
    Br J Pharmacol 115:133-41. 1995
    1. Single cell photometry and whole-cell patch clamp recording were used to study caffeine-induced intracellular Ca2+ signals and membrane currents, respectively, in endothelial cells freshly dissociated from rabbit aorta. 2...
  47. ncbi Inducing a cell-mediated immune response against peptides of the Plasmodium vivax circumsporozoite protein
    B E Thomas
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Ann Trop Med Parasitol 95:573-86. 2001
    ..variant (ANG) and the conserved region (region II) containing the hepatocyte-binding region extended to include a T-cell epitope (HBP). The study was conducted in outbred mice and two genetically unrelated inbred strains of mice...
  48. pmc Acid secretion and the H,K ATPase of stomach
    C Prinz
    University of California at Los Angeles
    Yale J Biol Med 65:577-96. 1992
    ..their effects on acid secretion mainly by stimulation of histamine release from the enterochromaffin-like (ECL) cell of the fundic gastric mucosa...
  49. pmc Gastric acid secretion: activation and inhibition
    G Sachs
    University of California Los Angeles, USA
    Yale J Biol Med 67:81-95. 1994
    Peripheral regulation of gastric acid secretion is initiated by the release of gastrin from the G cell. Gastrin then stimulates the cholecystokinin-B receptor on the enterochromaffin-like cell beginning a calcium signaling cascade...
  50. pmc Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor
    D Raeburn
    , Dagenham Research Centre, Essex
    Br J Pharmacol 113:1423-31. 1994
    ..In guinea-pig bronchoalveolar lavage (BAL) fluid, total inflammatory cell and eosinophil numbers were reduced by RP 73401 (ID50s: 3.9 +/- 0.8 micrograms kg-1 and 3.2 +/- 0...
  51. ncbi Expression of fibroblast growth factor (FGF)-10 in human colorectal adenocarcinoma cells
    A Matsuike
    Department of Pathology, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 68:397-404. 2001
    ..Its actions are dependent on its binding to the iiib isoform of the cell-surface FGF receptor 2 (FGFR2 iiib)...
  52. ncbi Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:237-45. 2000
    Gene expression relevant to abnormal cell differentiation and altered cell cycle in endometrial epithelial cells was investigated immunohistochemically in developing mouse uteri exposed neonatally to diethylstilbestrol (DES)...
  53. ncbi Effects of very high antibiotic concentrations on human intervertebral disc cell proliferation, viability, and metabolism in vitro
    G L Hoelscher
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina, USA
    Spine (Phila Pa 1976) 25:1871-7. 2000
    ..METHODS: In this study, 3H-thymidine incorporation, trypan blue exclusion, and cell metabolism were determined using cells from the human anulus grown in monolayer culture...
  54. ncbi Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro
    H E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, North Carolina 28232, USA
    Spine (Phila Pa 1976) 25:2153-7. 2000
    ..SUMMARY OF THE BACKGROUND DATA: Previous studies have shown that there is a small cell population in the aging human intervertebral disc...
  55. pmc Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids
    T A Swierkosz
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1335-42. 1995
    ..to investigate the effects of exogenous or endogenous nitric oxide (NO) on COX-2 in both intact and broken cell preparations. NOS activity was assessed by measuring the accumulation of nitrite using the Griess reaction...
  56. pmc Mechanism of action of the inhibitory effect of nifedipine on the growth of cultured aortic cells from spontaneously hypertensive and normotensive rats
    T Herembert
    CNRS URA 1482, Universite Rene Descartes, UFR des Saints Pères, Paris, France
    Br J Pharmacol 114:1703-9. 1995
    ..2. The effects of nifedipine on cell proliferation and on serum-induced DNA synthesis were determined by measuring the cell number and the incorporation ..
  57. pmc A role for endogenous histamine in interleukin-8-induced neutrophil infiltration into mouse air-pouch: investigation of the modulatory action of systemic and local dexamethasone
    M Perretti
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of Saint Bartholomew s Hospital, London
    Br J Pharmacol 112:801-8. 1994
    ..p.) resulted in a dose-dependent inhibition of the cell accumulation elicited by the chemokine, with a maximal reduction of approximately 50-60%...
  58. pmc Autoregulation of enterochromaffin-like cell histamine secretion via the histamine 3 receptor subtype
    M Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520-8062, USA
    Yale J Biol Med 69:9-19. 1996
    INTRODUCTION: The neuroendocrine histamine-secreting cell of the gastric fundus, the enferochromaffin-like cell, is the principal regulator of parietal cell acid secretion...
  59. ncbi Ultrastructural pathology of glial brain tumors revisited: a review
    P P Liberski
    Department of Oncology, Medical Academy Lodz, Poland
    Ultrastruct Pathol 21:1-31. 1997
    ..such clinico-pathological entities as pilocytic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma of tuberous sclerosis...
  60. pmc Evidence that the atypical 5-HT3 receptor ligand, [3H]-BRL46470, labels additional 5-HT3 binding sites compared to [3H]-granisetron
    L J Steward
    Department of Pharmacology, Medical School, University of Birmingham, Edgbaston
    Br J Pharmacol 116:1781-8. 1995
    ..2. In rat cerebral cortex/hippocampus, rat ileum, NG108-15 cell and HEK-5-HT3As cell homogenates, [3H]-BRL46470 bound with high affinity (Kd (nM): 1.57 +/- 0.18, 2.49 +/- 0.30, 1...
  61. pmc Study of mechanisms of electric field-induced DNA transfection. I. DNA entry by surface binding and diffusion through membrane pores
    T D Xie
    Department of Biochemistry, University of Minnesota College of Biological Sciences, St Paul 55108
    Biophys J 58:13-9. 1990
    ..DNA binding to the cell membrane greatly enhanced the efficiency of the transfection and this binding was increased by milimolar ..
  62. pmc A role for endothelin in bicuculline-induced neurogenic pulmonary oedema in rats
    C Herbst
    Department of Pharmacology and Toxicology, Ruhr University, Bochum, Germany
    Br J Pharmacol 115:753-60. 1995
    ..3. Concomitantly there was a time-dependent increase of big ET-1 and ET-1 levels in bronchoalveolar lavage (BAL) as determined by combined reverse phase high performance liquid chromatography (h.p.l.c.) and radioimmunoassay...
  63. ncbi Hemodilution as a method to reduce transfusion requirements in adolescent spine fusion surgery
    L A Copley
    Department of Orthopaedic Surgery, Eglin Air Force Base, Florida, USA
    Spine (Phila Pa 1976) 24:219-22; discussion 223-4. 1999
    ..1) autologous blood predonation, 2) controlled hypotensive anesthesia, 3) intraoperative salvage of shed blood (cell saver), 4) acute normovolemic hemodilution, and 5) transfusion decisions by clinical judgment rather than by a ..
  64. pmc Activation by intracellular GDP, metabolic inhibition and pinacidil of a glibenclamide-sensitive K-channel in smooth muscle cells of rat mesenteric artery
    H Zhang
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London
    Br J Pharmacol 114:662-72. 1995
    1. Single-channel recordings were made from cell-attached and isolated patches, and whole-cell currents were recorded under voltage clamp from single smooth muscle cells obtained by enzymic digestion of a small branch of the rat ..
  65. ncbi Killing of laminin receptor-positive human lung cancers by tumor infiltrating lymphocytes bearing gammadelta(+) t-cell receptors
    M Ferrarini
    Laboratori Immunoterapia Adottiva, Istituto Scientifico H S Raffaele
    J Natl Cancer Inst 88:436-41. 1996
    ..The monomeric laminin receptor, a 67-kd high-affinity laminin-binding protein, is expressed by a variety of normal cell types...
  66. ncbi Proliferating cell nuclear antigen in hypertrophied spinal ligaments. Immunohistochemical localization of proliferating cell nuclear antigen in hypertrophied posterior longitudinal ligament of the cervical spine
    H Motegi
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Japan
    Spine (Phila Pa 1976) 23:305-10. 1998
    STUDY DESIGN: An experimental immunohistochemical investigation using an antibody for proliferating cell nuclear antigen...
  67. ncbi Utility of reflex Gomori methenamine silver staining for Pneumocystis jirovecii on bronchoalveolar lavage cytologic specimens: a review
    Aziza Nassar
    Department of Pathology and Laboratory Medicine, School of Medicine, Emory University Hospital, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Diagn Cytopathol 34:719-23. 2006
    ..Its diagnosis is dependent on identification in bronchoalveolar lavage (BAL) specimens...
  68. ncbi Changes in immunocytochemical detectability of proteasome epitopes depending on cell growth and fixation conditions of lung cancer cell lines
    B M Machiels
    Department of Molecular Cell Biology and Genetics, University of Limburg, Maastricht, The Netherlands
    Eur J Cell Biol 66:282-92. 1995
    The localization of proteasome epitopes in the lung cancer cell lines NCI-H82, derived from a small cell lung cancer, and MR65, derived from a squamous cell lung carcinoma, was studied in relation to cell growth conditions...
  69. pmc The effect of non-steroidal anti-inflammatory drugs on the accumulation and release of interleukin-1-like activity by peritoneal macrophages from the mouse
    A K Bahl
    Department of Pharmacology, University College London
    Br J Pharmacol 113:809-14. 1994
    ..indomethacin, 100 nM to 10 microM, piroxicam, 1 to 100 microM, and sodium meclofenamate, 10 nM, all potentiated cell-associated IL-1-like activity in LPS- stimulated macrophages...
  70. ncbi Activation of CD4+ and CD8+ lymphocyte subsets by streptozotocin in the popliteal lymph node assay. II. Comparison with acute graft-vs-host reaction in H-2 incompatible F1 mouse hybrids
    K Krzystyniak
    Laboratoire d'Immunotoxicologie, INSERM U80, , Lyon, France
    Immunopharmacol Immunotoxicol 14:865-82. 1992
    ..Early cell activation and time-related changes in T- and B-lymphocyte subsets were monitored during the onset of the GVH ..
  71. ncbi Dose-response assessment and effect of particles in guinea pigs exposed chronically to diesel exhaust: analysis of various biological markers in pulmonary alveolar lavage fluid and circulating blood
    Yoko Ishihara
    Department of Hygiene and Public Health I, School of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Inhal Toxicol 14:1049-67. 2002
    ..diesel exhaust, various biomarkers for chronic obstructive lung diseases were studied using bronchoalveolar lavage (BAL) fluid and blood specimens...
  72. pmc Detachment of agglutinin-bonded red blood cells. II. Mechanical energies to separate large contact areas
    E Evans
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Biophys J 59:849-60. 1991
    ..the strength of adhesion between agglutinin-bonded membranes without ambiguity due to mechanical compliance of the cell body...
  73. ncbi [Suberosis: involvement of bronchoalveolar +mastocytes in the genesis of interstitial involvement]
    L Delgado
    Servicio de Inmunologia, Facultad de Medicina, Hospital de Sao Joao, Oporto
    Arch Bronconeumol 35:71-8. 1999
    ..Increased numbers of mast cells are present in bronchoalveolar lavage (BAL) fluid in interstitial lung diseases, suggesting that these cells also participate in chronic inflammatory ..
  74. ncbi [Quality comparison of modified neurolept-, balanced and intravenous anesthesia. 1. Study design and patient analysis of the Krefelder study 1992]
    H Harke
    Institut für Anaesthesie, Städtischen Krankenanstalten Krefeld
    Anaesthesist 44:531-7. 1995
    ..clinical trial was to test the hypothesis that three regimens of general anaesthesia--neurolept-(NLA), balanced (BAL), and intravenous propofol anaesthesia (IVA)--differ with regard to safety and comfort...
  75. ncbi The effect of glimepiride on pancreatic beta-cell function under hyperglycaemic clamp and hyperinsulinaemic, euglycaemic clamp conditions in non-insulin-dependent diabetes mellitus
    H E Clark
    Oxford Diabetes Centre, Radcliffe Infirmary, United Kingdom
    Horm Metab Res 28:445-50. 1996
    ..Glimepiride and glibenclamide stimulated beta-cell secretion and in the basal state both beta-cell secretory products insulin and C-peptide, were elevated in the ..
  76. ncbi Bronchoalveolar lavage in interstitial lung diseases: does the recovery rate affect the results?
    J Schildge
    Abteilung Pneumologie, Medizinische Klinik, St Vincentius Kliniken Karlsruhe, Karlsruhe, Germany
    Respiration 74:553-7. 2007
    Bronchoalveolar lavage (BAL) is an established diagnostic tool in interstitial lung diseases. BAL frequently yields findings of diagnostic value and at times even confirmatory diagnostic results.
  77. pmc Kinetics and mechanism of inhibition of serine esterases by fluorinated aminophosphonates
    G F Makhaeva
    Institute of Physiologically Active Compounds Russian Academy of Sciences, Chernogolovka 142432, Russia
    Chem Biol Interact 187:177-84. 2010
    ..1.1.5.), consistent with P-C bond breakage. Chemical reactivity experiments showed that diMe-FAP and diEt-FAP react with water to yield the corresponding dialkylphosphates and (CF(3))(2)CHNHS(O)(2)C(6)H(5), ..
  78. ncbi [Mast cells in bronchoalveolar lavage fluid of patients with interstitial lung diseases]
    J Schildge
    Medizinische Klinik, Abteilung Pneumologie, St Vincentius Kliniken Karlsruhe
    Pneumologie 57:202-7. 2003
    ..001) and HP (p < 0,01). Correlation analysis showed that an increased mast cell count correlated with: Higher age (sarcoidosis (p = 0.03); smaller vital capacity (sarcoidosis (p = 0...
  79. pmc Long-lasting activation of cation current by low concentration of endothelin-1 in mouse fibroblasts and smooth muscle cells of rabbit aorta
    T Enoki
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    Br J Pharmacol 115:479-85. 1995
    1. Recombinant human ETA receptors were expressed in a mouse fibroblast cell line (Ltk- cell) and functional coupling of the receptors with Ca2+ permeable channels at low concentrations of endothelin-1 (ET-1) was investigated using whole-..
  80. ncbi Intestinal absorption of dietary cholesteryl ester is decreased but retinyl ester absorption is normal in carboxyl ester lipase knockout mice
    W Weng
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York 10021, USA
    Biochemistry 38:4143-9. 1999
    Carboxyl ester lipase (CEL; EC 3.1.1.13) hydrolyzes cholesteryl esters and retinyl esters in vitro. In vivo, pancreatic CEL is thought to liberate cholesterol and retinol from their esters prior to absorption in the intestine...
  81. ncbi Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis
    Ahmer Kodvawala
    Department of Pathology and Laboratory Medicine, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio 45237, USA
    J Biol Chem 280:38592-8. 2005
    Carboxyl ester lipase (CEL, also called cholesterol esterase or bile salt-dependent lipase) is a lipolytic enzyme capable of hydrolyzing cholesteryl esters, triacylglycerols, and phospholipids in a trihydroxy bile salt-dependent manner ..
  82. ncbi Onco-suppressor genes in human cancer
    G Della Porta
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
    Tumori 75:329-36. 1989
    ..in tumor cells of altered or activated versions of cellular genes (oncogenes) that normally control cell growth and differentiation...
  83. ncbi Vitamin D analogs modulate the action of gonadal steroids in human vascular cells in vitro
    D Somjen
    Institute of Endocrinology Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    Am J Hypertens 13:396-403. 2000
    We have previously reported that estradiol (E2) and dihydrotestosterone (DHT) regulate cell growth in human umbilical arterial smooth muscle cells (SMC) and in an endothelial cell line (E304)...
  84. ncbi Thrombin contributes to bronchoalveolar lavage fluid mitogenicity in lung disease of the premature infant
    Willem A Dik
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Pediatr Pulmonol 35:34-41. 2003
    ..compartment is associated with pulmonary fibrosis in adults and animals, and contributes to bronchoalveolar lavage (BAL) fluid mitogenicity for fibroblasts...
  85. ncbi Pharmacokinetic considerations in development of a bioartificial liver
    Hiroo Iwata
    Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Clin Pharmacokinet 43:211-25. 2004
    ..We then discuss the advantages and disadvantages of BAL therapy in comparison with the non-biological therapies of haemodialysis and plasma exchange...
  86. pmc Experimental pulmonary inflammatory injury in the monkey
    S D Revak
    Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA 92037, USA
    J Clin Invest 76:1182-92. 1985
    ..Indicators of pulmonary injury included an increase in mean protein content of bronchoalveolar lavage (BAL) fluid from 0.51 mg/ml in untreated animals to 3.74 mg/ml and 6...
  87. pmc Passive mechanical behavior of human neutrophils: effect of cytochalasin B
    M A Tsai
    Department of Biophysics, University of Rochester School of Medicine and Dentistry, New York 14642
    Biophys J 66:2166-72. 1994
    Actin is a ubiquitous protein in eukaryotic cells. It plays a major role in cell motility and in the maintenance and control of cell shape...
  88. ncbi Capsule endoscopy is useful and safe for small-bowel surveillance in familial adenomatous polyposis
    Gaetano Iaquinto
    Avellino, Aviano, Italy
    Gastrointest Endosc 67:61-7. 2008
    ..cancer are major causes of death after a prophylactic colectomy in patients with familial adenomatous polyposis (FAP)...
  89. pmc Phenotypic instability of Arabidopsis alleles affecting a disease Resistance gene cluster
    Hankuil Yi
    Department of Biology, Washington University, One Brookings Drive, St, Louis, MO 63130, USA
    BMC Plant Biol 8:36. 2008
    Three mutations in Arabidopsis thaliana strain Columbia - cpr1, snc1, and bal - map to the RPP5 locus, which contains a cluster of disease Resistance genes...
  90. ncbi Increased in CD8 T lymphocytes in the BAL fluid of patients with sulfur mustard gas-induced pulmonary fibrosis
    Ali Emad
    Shiraz University of Medical Sciences, Pulmonary Section, Shiraz, Iran
    Respir Med 101:786-92. 2007
    In an attempt to understand better the potential role of the T cell in the pathogenesis of pulmonary fibrosis (PF) due to sulfur mustard gas inhalation, this study was designed to analyze bronchoalveolar lavage (BAL) lymphocyte subsets ..
  91. pmc Development and optimization of quantitative PCR for the diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid
    Prasanna D Khot
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    BMC Infect Dis 8:73. 2008
    ..Culture and histopathological examination of bronchoalveolar lavage (BAL) fluid are useful but have suboptimal sensitivity and in the case of culture may require several days for fungal ..
  92. pmc Detection of anionic antimicrobial peptides in ovine bronchoalveolar lavage fluid and respiratory epithelium
    K A Brogden
    Respiratory and Neurologic Disease Research Unit, National Animal Disease Center, Agricultural Research Service, U S Department of Agriculture, Ames, Iowa 50010, USA
    Infect Immun 66:5948-54. 1998
    ..However, their presence in bronchoalveolar lavage (BAL) fluid and tissues of the respiratory tract is unknown...
  93. ncbi Outcome of familial adenomatous polyposis: a retrospective study
    Chucheep Sahakitrungruang
    Colorectal Division, Department of Surgery, Chulalongkorn University, Bangkok 10330, Thailand
    J Med Assoc Thai 89:S155-60. 2006
    Familial adenomatous polyposis (FAP) is characterized by the presence of numerous colorectal adenomatous polyps that progress to colorectal cancer if left untreated...
  94. pmc Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit
    A Sala
    Center for Cardiopulmonary Pharmacology, Univ of Milan, Italy
    Br J Pharmacol 110:1206-12. 1993
    1. We have studied the transcellular biosynthesis of bioactive leukotrienes (LTs), generated upon blood cell-vascular wall interactions and their functional consequences, in the spontaneously beating, cell-perfused, heart of the rabbit...
  95. ncbi The activity of cholesterol esterase and ceruloplasmin are inversely related in the serum of men with atherosclerosis obliterans
    M Piorunska-Stolzmann
    Department of General Chemistry, Chair and Department of Clinical Biochemistry, Medical University, Poznan, Poland
    Med Sci Monit 7:940-5. 2001
    ..b>Cholesterol esterase participates in lipoprotein degradation by the hydrolysis of cholesteryl esters in low density lipoproteins ..
  96. pmc Stimulation of human umbilical vein endothelial cell proliferation by A2-adenosine and beta 2-adrenoceptors
    V Sexl
    Institute of Pharmacology, University of Vienna, Austria
    Br J Pharmacol 114:1577-86. 1995
    1. Adenosine is known to stimulate capillary outgrowth and endothelial cell proliferation, but the underlying mechanism has not been identified...
  97. ncbi Molecular cloning and expression of cDNA for rat pancreatic cholesterol esterase
    J A Kissel
    Department of Pathology, University of Cincinnati, College of Medicine, OH 45267 0529
    Biochim Biophys Acta 1006:227-36. 1989
    A full-length cDNA complementary to the rat pancreatic cholesterol esterase mRNA was isolated by screening a rat pancreatic cDNA expression library in lambda gt11 vector with antibodies against the porcine pancreatic cholesterol esterase...
  98. pmc Effects of nitric oxide donors, S-nitroso-L-cysteine and sodium nitroprusside, on the whole-cell and single channel currents in single myocytes of the guinea-pig proximal colon
    R J Lang
    Department of Physiology, Monash University, Clayton Victoria, Australia
    Br J Pharmacol 123:505-17. 1998
    ..single myocytes isolated from the circular muscle layer of the guinea-pig proximal colon, by use of standard whole-cell and single channel recording techniques. 2...
  99. ncbi [Topotecan: a new field of use]
    S Ferrari
    , Pavia
    Tumori 85:S23-8. 1999
    ..DNA topoisomerase I, an enzyme that is present in cells in concentration relatively independent of the stage in the cell cycle...
  100. ncbi Protein adsorption and endothelial cell attachment and proliferation on PAPI-based additive modified poly(ether urethane ureas)
    M R Brunstedt
    Department of Macromolecular Science, Case Western Reserve University, Cleveland, OH 44106-4907
    J Biomed Mater Res 27:499-510. 1993
    ..vascular interactions with poly(ether urethane urea) (PEUU) materials, protein adsorption, and endothelial cell attachment and proliferation assays were performed on a base PEUU formulation, on PEUU formulations loaded with ..
  101. ncbi Conductivity detection cell for capillary zone electrophoresis with a solution mediated contact of the separated constituents with the detection electrodes
    R Bodor
    Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic
    J Chromatogr A 916:31-40. 2001
    A contact conductivity detection cell for capillary zone electrophoresis (CZE) with an electrolyte solution mediated contact of the separated constituents with the detection electrodes (ESMC cell) was developed in this work...

Research Grants95

  1. Dean Sheppard; Fiscal Year: 2016
    ..These projects will be supported by a human lung cell and tissue core, a longitudinal cohort core, a mediciinal chemistry core and a centralized administrative core...
  2. Aric L Gregson; Fiscal Year: 2015
    ..The frequencies of BAL Treg correlated with BAL levels of the CCR7 ligand CCL21, which itself appears to protect against BOS...
  3. Robert J Blount; Fiscal Year: 2014
    ..We will obtain alveolar macrophages from each participant using bronchoscopy with bronchoalveolar lavage (BAL) (Specific Aim 2)...
  4. Richard F Silver; Fiscal Year: 2016
    ..of more effective TB vaccination programs, and, more generally, to understanding the mechanisms by which cell-mediated immunity functions within the human lung...
  5. Benjamin D Medoff; Fiscal Year: 2016
    ..These data will be correlated with assessment of T cell activity and oxidative stress in bronchoalveolar lavage (BAL) fluid and peripheral blood...
  6. Dorothy S Cheung; Fiscal Year: 2014
    ..The atopic risk has been assumed to be due to the anti-viral immune response. One of the earliest immune cell types to respond to respiratory viral infections is the polymorphonuclear neutrophil (PMN)...
  7. Chronic Granulomatous Lung Inflammation Elicited by Carbon Nanotubes
    Mary Jane Thomassen; Fiscal Year: 2013
    ..examine CCR5 involvement in MWCNT granulomas by quantifying CCR5 receptor and chemokines in bronchoalveolar lavage (BAL) derived alveolar macrophages, BAL fluids, and in granulomatous foci isolated by laser-capture microdissection [LCM]..
  8. Longitudinal Studies of HIV-Associated Bacterial Pneumonia
    William N Rom; Fiscal Year: 2013
    ..We will use high-speed FACS cell sorting to separate macrophages, lymphocytes, and neitrophils for mechanistic studies...
  9. John K McGuire; Fiscal Year: 2014
    ..of a specialized population of dendritic cells (DC) expressing CD103 (aE[unreadable]7-integrin), a leukocyte cell-surface receptor for which E- cadherin is the only known ligand...
  10. HIGH-DOSE VITAMIN D AND ANTIMICROBIAL PEPTIDE EXPRESSION IN LUNG FAILURE
    Thomas R Ziegler; Fiscal Year: 2012
    ..whether our vitamin D regimens upregulate concentrations of LL-37 and hBD-2 in plasma and bronchoalveolar lavage (BAL) fluid, cathelicidin and hBD-2 mRNA in peripheral blood mononuclear cells (PBMCs), and LL-37 and hBD-2 expression ..
  11. Andrew M Tager; Fiscal Year: 2015
    ..will investigate the hypothesis that S1P signaling through S1P1 expressed by endothelial cells rather than by other cell types is specifically responsible for the ability of this pathway to limit both vascular leak and pulmonary ..
  12. David J Lederer; Fiscal Year: 2016
    ..after lung transplantation, and (3) measurement of adipokines and cytokines in plasma and bronchoalveolar lavage (BAL) fluid and lymphocyte phenotypes in the circulating and lung compartments in participants at three lung transplant ..
  13. Laurence Huang; Fiscal Year: 2016
    ..provide oropharyngeal washing (OPW, gargle) specimens and will undergo bronchoscopy with bronchoalveolar lavage (BAL) for the diagnosis of PCP and TB...
  14. ISELA CARIDAD VALERA; Fiscal Year: 2016
    ..Using blood and bronchoalveolar lavage (BAL), we will test the hypothesis that expression levels of an X chromosome-encoded gene, IL13RA2, in these samples ..
  15. Bronchoalveolar Lavage Cell Biomarkers in Lung Rejection
    Marshall I Hertz; Fiscal Year: 2010
    ..Our prior studies demonstrate that acute lung rejection histology is characterized by coordinately increased BAL cell expression of cytotoxic T-lymphocyte markers;and that BAL fluid and cells reveal biomarkers of the hallmark ..
  16. Jenny T Mao; Fiscal Year: 2015
    ..In addition, Pre- and post treatment plasma and BAL will be used in co-cultures with the nonsmall cell lung cancer cell (NSCLC) line A549 and the bronchial premalignant cell line 1198...
  17. Anti-carcinogenic effects of White Tea on Lung Cancer
    Jenny T Mao; Fiscal Year: 2010
    ..Specific Aim 1.1A: To examine effects of WTE on the induction of apoptosis in nonsmall cell lung cancer (NSCLC) and to further characterize the molecular mechanisms responsible for the WTE-induced apoptotic ..
  18. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..Lung alveolar epithelial cell (AEC) injury and apoptosis are cardinal features of ALI;an improved understanding of this process in T/HS- induced ..
  19. The LPA Pathway in Lung Fibrosis: Novel Mediators and New Therapeutic Targets
    Andrew M Tager; Fiscal Year: 2010
    ..In this model, levels of LPA increase in bronchoalveolar lavage (BAL) fluid following bleomycin challenge, and mice lacking LPA1, one of LPA's receptors, are markedly protected ..
  20. Molecular profiling and immunomodulatory interventions
    Abraham Shaked; Fiscal Year: 2009
    ..and evolving literature that mRNA profiling of peripheral blood cells, urinary cells, and bronchoalveolar lavage (BAL) cells are diagnostic of allograft status...
  21. Lisa A Maier; Fiscal Year: 2014
    ..Evaluation of BAL microbiome is proposed to further define the molecular profiles of disease and disease phenotype, as it is likely ..
  22. Linking Genetics, Genomics and Phenomics to Better Understand Asthma Severity
    Sally E Wenzel; Fiscal Year: 2010
    ..The underlying hypothesis is that lung cell gene expression, modulated by the genetic background (GWAS) and the environment (epigenetic profiling), will track ..
  23. Mark Larché; Fiscal Year: 2016
    ..Research and Validation Center will use unique Major Histocompatibility (MHO) class II tetramers containing T cell epitopes of the major cat allergen Pel d 1 in order to characterize allergen-specific T cells before and after ..
  24. Vibha N Lama; Fiscal Year: 2016
    ..Our preliminary data further demonstrate that LR-MSCs are capable of both inhibiting T cell responses and undergoing differentiation to fibrogenic myofibroblasts...
  25. LPA and Edg Receptors in the Pulmonary Immune Respose
    STEVEN N GEORAS; Fiscal Year: 2013
    ..is now known to regulate many aspects of immune responses, with recent studies indicating a role in regulating cell homing. Growing evidence indicates that LPA contributes to the pathogenesis of asthma...
  26. Mulago Inpatient Noninvasive Diagnosis of Pneumocystis Pneumonia (MIND PCP) Study
    John Davis; Fiscal Year: 2007
    ..are common, other processes may cause pneumonia in these patients, so bronchoscopy with bronchoalveolar lavage (BAL) is often indicated for definitive diagnosis, especially when empiric treatments fail...
  27. Lynn M Schnapp; Fiscal Year: 2014
    ..To begin to address this question, we will examine whether bronchoalveolar lavage (BAL) from HIV+ patients is enriched with markers of SASP, and can induce senescence of primary lung epithelial cells ..
  28. Andrew H Limper; Fiscal Year: 2016
    ..Numerous studies demonstrate that Pneumocystis (Pc) cell wall components including ?-glucans interact with alveolar macrophages and epithelial cells to stimulate the ..
  29. Brent E Palmer; Fiscal Year: 2016
    ..PD-1 is upregulated on T cells in the setting of chronic antigen exposure, contributing to T cell dysfunction and an inability to clear HIV-1...
  30. Li Shu Wang; Fiscal Year: 2014
    ..short-term treatment of sporadic colorectal cancer patients with oral BRB powder (20g/3x/day) significantly reduced cell proliferation rates and produced a positive trend for changes in apoptosis, angiogenesis, and in genes associated ..
  31. LRH-1: Structure-based Approach to Drug Design for Gastrointestinal Tumors
    James Bayrer; Fiscal Year: 2013
    ..This orphan nuclear receptor has also been shown to be active in cell proliferation via the Wnt/ -catenin and PDX-1 hedgehog pathways, which are active in the tumorigenesis of HCC and ..
  32. Modifiers of Intestinal Tumor Progression
    Linda D Siracusa; Fiscal Year: 2012
    ..The adenomatous polyposis coli (APC) tumor suppressor gene is mutated in Familial Adenomatous Polyposis (FAP), a dominant inherited disorder that predisposes individuals to developing colorectal cancer (Groden et al. 1991)...
  33. Francis M Giardiello; Fiscal Year: 2015
    ..markers of epithelial proliferation (ornithine decarboxylase, polyamines and immunohistochemistry for proliferating cell nuclear antigen), apoptosis (apoptotic index by morphologic measurement and TUNEL assay), and cyclooxygenase- 2 ..
  34. MyFAP: A Multimedia Intervention for Adolescents and Young Adults with FAP
    JEFFERY MCLAUGHLIN; Fiscal Year: 2012
    ..org, for adolescents and young adults (AYAs) with familial adenomatous polyposis (FAP). The main research goal of Phase II is to evaluate the efficacy of MyFAP...
  35. Use of Closely Related Inbred Strains to Identify Modifier Loci of Tumorigenesis
    Linda D Siracusa; Fiscal Year: 2013
    ..The adenomatous polyposis coli (APC) tumor suppressor gene is mutated in Familial Adenomatous Polyposis (FAP), an inherited disorder that predisposes individuals to developing polyps in their intestinal tract and which ..
  36. Eva S Anton; Fiscal Year: 2016
    ..Subsequently, they contribute to the formation of glial cell lineages in the mature brain...
  37. JAMES PETER ROBINSON; Fiscal Year: 2014
    ..The candidate's hypothesis is that aberrant stromal cell signaling following loss or haploinsufficiency of APC drives tumorigenesis in adjacent predisposed epithelial cells...
  38. Doxycycline for COPD in HIV-Infected Patients
    Robert J Kaner; Fiscal Year: 2013
    ..activity in epithelial lining fluid and cells obtained by bronchoscopy and doxycycline levels in blood, ELF and BAL cell pellets...
  39. Kit Inhibition in Asthma (KIA)
    Elliot Israel; Fiscal Year: 2012
    ..Imatinib is a specific tyrosine kinase inhibitor that inhibits cKit the receptor for stem cell factor (SCF) on mast cells. SCF is critical for mast cell homeostasis and function...
  40. William C Hahn; Fiscal Year: 2014
    ..human oncogenes by integrating high throughput functional genomic approaches with experimental models of human cell transformation and on-going structural characterization of cancer genomes, we found that CDK8, a component of the ..
  41. T cell response in scleroderma lung disease: from pathogenesis to clinical care
    Francesco Boin; Fiscal Year: 2012
    ..This proposal will investigate the value of quantifying effector T cell polarization (type 1/type 2) and autoantigen- topoisomerase-1 (topo-1)-specific T cells as measures of lung disease ..
  42. Molecular Characterization of Sporadic Colorectal Cancer in the Young from India
    Jonathan R Pollack; Fiscal Year: 2010
    ..HNPCC) caused mainly due to germline inactivation of mismatch repair genes and the Familial Adenomatous Polyposis (FAP) caused mainly due to the germline inactivation of the Adenomatous Polyposis Coli tumor suppressor gene...
  43. Animal model of Gardner's syndrome, a life threatening form of familial cancer
    Yong Sik Bong; Fiscal Year: 2013
    ..a role for the vitamin D receptor (VDR) in Gardner's syndrome, a derivative of familial adenomatous polyposis (FAP)...
  44. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2011
    ..2. To determine the role of iNOS in modulating alveolar macrophage-Regulatory T cell interactions to promote resolution of ALI...
  45. Franco R D'Alessio; Fiscal Year: 2014
    ..2. To determine the role of iNOS in modulating alveolar macrophage-Regulatory T cell interactions to promote resolution of ALI...
  46. p120 and Kaiso dysregulation in intestinal tumorigenesis
    SARAH PALMER SHORT; Fiscal Year: 2013
    ..Loss of the APC gene product (Apc) activates the Canonical Wnt signaling pathway, culminating in cell proliferation, transformation, and tumor formation...
  47. Oncolytic Viruses with Therapeutic Genes in the Treatment of Breast Cancer
    DANUTA B KOZBOR; Fiscal Year: 2013
    ..determinant of protumorigenic behavior of MDSCs, in tumor-infiltrating granulocytes, ii) reduced percentage of FAP+ cancer associated fibroblasts (CAFs), iii) decreased levels of CXCL12, and iv) collapse of the tumor vasculature...
  48. Combined Chemoprevention in Beta-Catenin Mutant Mice
    Gayle Orner; Fiscal Year: 2004
    ..NSAIDs are effective at preventing polyp formation in familial adenomatous polyposis (FAP) patients having a genetic predisposition to cancer...
  49. Combined effects of tea plus NSAIDS towards colon cancer
    Gayle Orner; Fiscal Year: 2004
    ..NSAIDs are effective at preventing polyp formation in familial adenomatous polyposis (FAP) patients having a genetic predisposition to cancer...
  50. Chemoprevention of Duodenal Polyps in FAP
    James DiSario; Fiscal Year: 2003
    ..on duodenal adenomatous polyps and on adenoma and mucosal apoptosis assays in Familial Adenomatous Polyposis (FAP) patients who have had colectomy or Attenuated Adenomatous Polyposis Coli (AAPC) patients whom may or may not have ..
  51. RELEVANCE OF GENOMIC ALTERATIONS IN COLORECTAL CANCER
    Walter Curran; Fiscal Year: 2004
    ..to this malignancy has been identified among individuals and families with familial adenomatous polyposis (FAP) and with hereditary non-polyposis colorectal cancer (HNPCC)...
  52. MARKERS FOR STEM CELL-LIKE COLONIC CRYPT BASE CELLS
    Bruce Boman; Fiscal Year: 2004
    ..Our immediate objective is to develop markers for colonic stem cell enriched (SCE) preparations...
  53. Multimedia Intervention for Adolescents and Young Adults with FAP
    Susan Peterson; Fiscal Year: 2007
    ..a web-based multimedia intervention program for adolescents and young adults with familial adenomatous polyposis (FAP), an inherited colorectal cancer syndrome...
  54. GENES FROM THE FAP LOCUS
    KENNETH KINZLER; Fiscal Year: 2001
    ..Similarly, familial adenomatous polyposis (FAP) patients, who inherit germline APC mutations, develop hundreds of colorectal tumors...
  55. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2005
    ..elucidation of the genetics of human colorectal cancer has led to the identification of the adenomatous polyposis cell (APC) gene as the putative "gatekeeper" of colorectal carcinogenesis...
  56. AP4 Center for Studies on Hereditary Colorectal Cancer
    Bruce Boman; Fiscal Year: 2004
    ..HCC) because: I) HCC, including Hereditary Non-polyposis Colon Cancer (HNPCC) and Familial Adenomatous Polyposis (FAP) are subsets (approximately 3%, approximately 1%) of colorectal cancer (CRC) and individuals carrying an HCC trait (..
  57. Lobelia Samavati; Fiscal Year: 2016
    ..Recently, we have shown that bronchoalveolar lavage (BAL) cells and alveolar macrophages (AMs) of sarcoid subjects exhibit constitutively active p38, but lack active ERK...
  58. Enhancing Nrf2 by Sulforaphane Treatment in COPD
    Robert A Wise; Fiscal Year: 2012
    ..Collections of alveolar macrophages by BAL, bronchial epithelial cells by endobronchial brushings will be performed at baseline and 4 weeks...
  59. A Brent Carter; Fiscal Year: 2015
    ..Moreover, this decrease in expression was associated with decreased MMP-9 activity in BAL fluid and increased collagen secretion by fibroblasts exposed to BAL fluid...
  60. PIA JOHANNA HAUK; Fiscal Year: 2014
    ..The percentages of BAL neutrophils correlated with metalloproteinase (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1 and MMP-9/..
  61. An Early Diagnostic Marker for Ventilator-Associated Pneumonia
    STEVEN PALAZZO; Fiscal Year: 2010
    ..Suspected clinical cases of VAP are diagnosed using Broncheoalveolar lavage (BAL), an invasive and costly procedure that requires physician-directed access to the lower respiratory tract in order ..
  62. Aveolar Macrophage Apoptosis and Pneumocystis
    Chao Hung Lee; Fiscal Year: 2009
    ..This proposal will use steroid-immunosuppressed rats and L3T4 cell- depleted mice to test the hypothesis that alveolar macrophages apoptosis is caused directly by polyamines or ..
  63. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  64. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..Inflammation is assessed by examining BAL markers of inflammation (protein, PMNs, TNF-[unreadable], and MIP-1[unreadable])...
  65. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..In summary, B cell dysregulation is likely to play a major role in the progression to AIDS in HIV-infected patients...
  66. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..Inflammation is assessed by examining BAL for protein, PMNs, TNF-[unreadable], and MIP-1[unreadable]...
  67. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..We also ask how the intra-store calcium determines how much will move, or when the movement will cease. Therefore, our work should help understand why signals fail, or get out of hand...
  68. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..compounds such as calcineurin inhibitors (Cyclosporine A), FK-506, and rapamycin, which are known suppressors of T-cell function. CyA, FK- 506, and rapamycin suppressed both Th1 and Th17 cells and thus were non-selective...
  69. Bi-functional Therapeutics for Allergy-BFTA
    Swey Shen Chen; Fiscal Year: 2010
    ..directed to C(2-3L constrained within the (-barrel of GFP, inhibit IgE binding to Fc(RI( and prevent mast cell activation...
  70. John W Wiley; Fiscal Year: 2016
    ..studies demonstrating genome-wide distribution of methylation and acetylation sites in primary cells and human cell lines. It is unknown whether chronic stress regulates peripheral pain pathways via epigenetic mechanisms...
  71. Non-coding RNA engineers antibody diversity
    Uttiya Basu; Fiscal Year: 2011
    ..CSR is a B cell-specific DNA rearrangement reaction that replaces an Ig heavy chain constant region gene (CH) from C[unreadable] ..
  72. Pathogenic Mechanisms of PBEF in Ventilator Induced Lung Injury
    Joe G N Garcia; Fiscal Year: 2012
    ..Our genomic-intensive approaches (murine, canine, human ALI models) captured pre-B cell colony enhancing factor (PBEF) as a novel ALI susceptibility candidate gene and novel biomarker in sepsis and ALI...
  73. Natasha N Chattergoon; Fiscal Year: 2016
    ..In larger mammals, like the sheep, cardiomyocytes gradually cease dividing and become primarily binucleated (terminal differentiation) just prior to birth...
  74. Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    ANDRE ELIAS NEL; Fiscal Year: 2010
    ..from the nose of anesthesized animals, will assess OVA-specific IgE levels in parallel with BAL differential cell counts and lung histology. These studies will be carried out in phases through years 1-2...
  75. Brian Till; Fiscal Year: 2016
    ..CD20-specific T cells Non-Hodgkin lymphoma is diagnosed in more than 70,000 Americans each year, and aggressive B-cell lymphomas comprise approximately 35-40% of these cases...
  76. Ming Hui Fan; Fiscal Year: 2014
    ..Dr. Fan will study fibroblast activation protein (FAP)-a type II integral cell surface serine protease with dipeptidyl peptidase, endopeptidase, and collagenase activity-as a critical factor in ..
  77. ORAL CYCLOPHOSPHAMIDE VS ORAL PLACEBO IN SSC ALVEOLITIS
    Daniel Furst; Fiscal Year: 2001
    ..usually preceded by inflammation which can be detected by examination of cells obtained by bronchoalveolar lavage (BAL)...
  78. MULTIDAY EXPOSURE TO O3 IN ASTHMA
    John Balmes; Fiscal Year: 2002
    ..asthmatic subjects has been generated from studies involving bronchoscopy and analysis of bronchoalveolar lavage (BAL) fluid...
  79. SCLERODERMA LUNG STUDY
    Arthur Theodore; Fiscal Year: 2003
    ..usually preceded by inflammation which can be detected by examination of cells obtained by bronchoalveolar lavage (BAL)...
  80. GM-CSF THERAPY FOR ALVEOLAR PROTEINOSIS
    Mary Jane Thomassen; Fiscal Year: 2003
    ..determining cellular source of IL-10 in PAP, the effect of IL-10 on GM-CSF production and the effect of IL-10 on B cell proliferation and antibody production of PAP patients...
  81. TUBERCULOSIS, HIV AND SURFACTANT APOPROTEINS
    William Martin; Fiscal Year: 2002
    ..Studies from this laboratory indicate that bronchoalveolar lavage (BAL) fluid from HIV subjects contains a factor that promotes attachment of MTB to AM...
  82. Green Tea Anticancer Mechanisms in Smokers
    Philip Diaz; Fiscal Year: 2009
    ..hypothesis: in young adult smokers, 6 weeks of 6 cups of green tea/d produces changes in bronchoalveolar lavage (BAL) samples related to improved anti- lung cancer defense mechanisms...
  83. Planning a clinical trial of Flash-heated breast milk to decrease morbidity, impr
    Caroline J Chantry; Fiscal Year: 2010
    ..Many HIV- positive mothers in resource poor areas face a dilemma about how to feed their babies after they cease exclusively breastfeeding...
  84. LUNG LAVAGE PROCOAGULANTS IN LUNG INJURY AND REPAIR
    Steven Idell; Fiscal Year: 1990
    ..A factor X activating procoagulant activity has been found in bronchoalveolar lavage (BAL) from the lungs of patients with ARDS...
  85. PANCREATIC LIPASES AND COLIPASE IN LIPOLYSIS AND OBESITY
    Mark Lowe; Fiscal Year: 2007
    ..The Specific Aims in this grant are to: 1) Define the contribution of carboxyl ester lipase (CEL) and pancreatic lipase related protein 2 (PLRP2) to the digestion of dietary fat...
  86. REGULATION OF CHOLESTEROL ESTERASE IN STEROIDOGENESIS
    FREDRIC KRAEMER; Fiscal Year: 1999
    ..potential substrate enters the steroidogenic pathway as free cholesterol, signifies the important role of cholesterol esterase in the regulation of steroidogenesis...
  87. Irreversible inhibitors of cholesterol esterase
    LORRAINE DECK; Fiscal Year: 2005
    Pancreatic cholesterol esterase (CE) has a dual function in the absorption of dietary cholesterol...
  88. Role of Lipolytic Enzymes in Intestinal Lipid Transport
    David Hui; Fiscal Year: 2009
    ..Our earlier data have shown that carboxyl ester lipase (CEL) influences chylomicron production, possibly by a mechanism related to its ability to hydrolyze ceramides in the ..
  89. Carboxyl Ester Lipase Affects Hepatic HDL Metabolism
    PHILIP HOWLES; Fiscal Year: 2009
    ..Carboxyl ester lipase (CEL), also called cholesterol esterase and bile salt-stimulated lipase, is made and secreted by the liver...
  90. LIPID AND CHOLESTEROL ESTERASE IN NEONATAL GUT INTEGRITY
    PHILIP HOWLES; Fiscal Year: 1999
    ..The milk BSSL is identical to pancreatic cholesterol esterase (CEH) and may serve a similar function before onset of CEH biosynthesis in mature pancreas...