CEACAM5

Summary

Gene Symbol: CEACAM5
Description: carcinoembryonic antigen related cell adhesion molecule 5
Alias: CD66e, CEA, carcinoembryonic antigen-related cell adhesion molecule 5, meconium antigen 100
Species: human

Top Publications

  1. doi Evaluation of tumor markers (HER-2/neu oncoprotein, CEA, and CA 15.3) in patients with locoregional breast cancer: prognostic value
    Rafael Molina
    Hospital Clinic, Barcelona, Spain
    Tumour Biol 31:171-80. 2010
  2. doi The importance of preoperative elevated serum levels of CEA and CA15-3 in patients with breast cancer in predicting its histological type
    A K Agrawal
    2nd Department of General and Oncological Surgery, Wroclaw Medical University, Wroclaw, Poland
    Folia Histochem Cytobiol 48:26-9. 2010
  3. ncbi HER-2 gene amplification, serum nucleosomes, CEA and CA15.3 tumor markers in breast cancer patients
    M M Zeiwar
    Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
    Egypt J Immunol 14:29-41. 2007
  4. ncbi Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth
    Thomas Wirth
    Department of Oncology and Surgery, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Clin Exp Metastasis 19:155-60. 2002
  5. pmc Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers
    Rosalyn D Blumenthal
    Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ 07109, USA
    BMC Cancer 7:2. 2007
  6. pmc Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen
    N Beauchemin
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 7:3221-30. 1987
  7. ncbi Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence
    S Oikawa
    Biochem Biophys Res Commun 142:511-8. 1987
  8. pmc Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts
    F J Eidelman
    McGill Cancer Centre, Biochemistry Department, McGill University, Montreal, Quebec, Canada
    J Cell Biol 123:467-75. 1993
  9. ncbi Human carcinoembryonic antigen functions as a general inhibitor of anoikis
    C Ordonez
    McGill Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Cancer Res 60:3419-24. 2000
  10. ncbi Controlled ribozyme targeting demonstrates an antiapoptotic effect of carcinoembryonic antigen in HT29 colon cancer cells
    E Soeth
    Department of Oncology and Surgery, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Clin Cancer Res 7:2022-30. 2001

Research Grants

  1. A MACROPHAGE PROTEIN IN COLON TUMORIGENESIS
    Aniruddha Ganguly; Fiscal Year: 2001
  2. Mechanism of Cognitive Dysfunction: CEA and Stenting
    ERIC JOHN HEYER; Fiscal Year: 2012
  3. Carotid angioplasty and stenting in the elderly
    Brahmajee Nallamothu; Fiscal Year: 2009
  4. Robert Harris; Fiscal Year: 2015
  5. Victor C Yang; Fiscal Year: 2015
  6. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    Lopa Mishra; Fiscal Year: 2010
  7. Comparative Effectiveness of Treatment Options for Asymptomatic Carotid Disease
    Steven D Pizer; Fiscal Year: 2013
  8. Salomeh Keyhani; Fiscal Year: 2016
  9. PET/MRI of atherosclerosis
    Chun Yuan; Fiscal Year: 2012
  10. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012

Patents

  1. Cea binding agents to reverse cea-mediated tumorigenic effects onhuman cancer cells and uses thereof

Detail Information

Publications976 found, 100 shown here

  1. doi Evaluation of tumor markers (HER-2/neu oncoprotein, CEA, and CA 15.3) in patients with locoregional breast cancer: prognostic value
    Rafael Molina
    Hospital Clinic, Barcelona, Spain
    Tumour Biol 31:171-80. 2010
    ..5%, carcinoembryonic antigen (CEA) in 15.9%, and cancer antigen (CA) 15.3 in 19.7% of the patients...
  2. doi The importance of preoperative elevated serum levels of CEA and CA15-3 in patients with breast cancer in predicting its histological type
    A K Agrawal
    2nd Department of General and Oncological Surgery, Wroclaw Medical University, Wroclaw, Poland
    Folia Histochem Cytobiol 48:26-9. 2010
    ..was to assess relationship between breast cancer histological type and the presence of increased serum levels of CEA and CA 15-3. The study population was 428 patients (all women, mean age 52...
  3. ncbi HER-2 gene amplification, serum nucleosomes, CEA and CA15.3 tumor markers in breast cancer patients
    M M Zeiwar
    Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
    Egypt J Immunol 14:29-41. 2007
    ..The study was designed to assess the usefulness of HER-2 gene amplification, serum nucleosomes, CEA and CA15...
  4. ncbi Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth
    Thomas Wirth
    Department of Oncology and Surgery, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Clin Exp Metastasis 19:155-60. 2002
    It has been suggested that carcinoembryonic antigen (CEA) enhances metastatic seeding of colon cancer cells due to its homo- and heterophilic binding properties...
  5. pmc Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers
    Rosalyn D Blumenthal
    Garden State Cancer Center, Center for Molecular Medicine and Immunology, Belleville, NJ 07109, USA
    BMC Cancer 7:2. 2007
    Many breast, pancreatic, colonic and non-small-cell lung carcinoma lines express CEACAM6 (NCA-90) and CEACAM5 (carcinoembryonic antigen, CEA), and antibodies to both can affect tumor cell growth in vitro and in vivo...
  6. pmc Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen
    N Beauchemin
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 7:3221-30. 1987
    Carcinoembryonic antigen (CEA) expression is perhaps the most prevalent of phenotypic changes observed in human cancer cells. The molecular genetic basis of this phenomenon, however, is completely unknown...
  7. ncbi Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence
    S Oikawa
    Biochem Biophys Res Commun 142:511-8. 1987
    ..to the mRNA encoding a polypeptide which is immunoreactive with the antisera specific to carcinoembryonic antigen (CEA) (1) are cloned...
  8. pmc Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts
    F J Eidelman
    McGill Cancer Centre, Biochemistry Department, McGill University, Montreal, Quebec, Canada
    J Cell Biol 123:467-75. 1993
    Human carcinoembryonic antigen (CEA), a widely used tumor marker, is a member of a family of cell surface glycoproteins that are overexpressed in many carcinomas...
  9. ncbi Human carcinoembryonic antigen functions as a general inhibitor of anoikis
    C Ordonez
    McGill Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Cancer Res 60:3419-24. 2000
    Human carcinoembryonic antigen (CEA), a widely used tumor marker, and CEACAM6 [formerly nonspecific cross-reacting antigen (NCA)] are up-regulated in many types of human cancers, whereas family member CEACAM1 [formerly biliary ..
  10. ncbi Controlled ribozyme targeting demonstrates an antiapoptotic effect of carcinoembryonic antigen in HT29 colon cancer cells
    E Soeth
    Department of Oncology and Surgery, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Clin Cancer Res 7:2022-30. 2001
    Clinical studies suggest that carcinoembryonic antigen (CEA) is associated with metastatic progression of colon cancer. However, the biological function of CEA is not well understood...
  11. ncbi Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells
    Regina Hampton
    Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA
    Oncogene 21:7817-23. 2002
    ..In colon cancer patients, carcinoembrynic antigen (CEA) and cytokeratin 20 (CK20) have been frequently used for RT-PCR based tumor cell detection, but the specificity in ..
  12. pmc Elevation of carcinoembryonic antigen and CA-125 in a patient with multivisceral tuberculosis
    M Mansour
    Department of Medicine, Interfaith Medical Center, Brooklyn, New York, USA
    J Natl Med Assoc 89:142-3. 1997
    ..Her carcinoembryonic antigen (CEA) and CA-125 levels were elevated (400 micrograms/L and 331 micrograms/L, respectively)...
  13. ncbi An experimental model for pharmacokinetic studies of monoclonal antibodies in human colonic cancer
    H Ahlstrom
    Department of Diagnostic Radiology, Akademiska sjukhuset, Uppsala, Sweden
    Acta Oncol 26:447-51. 1987
    ..125I-labelled anti-carcinoembryonic antigen (anti-CEA) monoclonal antibodies were injected intra-arterially (i.a...
  14. pmc The production of a bispecific anti-CEA, anti-hapten (4-amino-phthalate) hybrid-hybridoma
    F Lloyd
    Roswell Park Memorial Institute, Buffalo, New York
    J Natl Med Assoc 83:901-4. 1991
    ..fusion technique was used to produce a monoclonal antibody capable of binding both carcinoembryonic antigen (CEA) and the hapten 4-amino-phthalate...
  15. ncbi Brenner tumor of the ovary: a comparative immunohistochemical and ultrastructural study with transitional cell carcinoma of the bladder
    N G Ordonez
    University of Texas M D Anderson Cancer Center, Houston, USA
    Ultrastruct Pathol 24:157-67. 2000
    ..the bladder using antibodies to thrombomodulin (TM), cytokeratin 20, cytokeratin 7, and carcinoembryonic antigen (CEA), all of which have been shown to react with TCCs of urothelial origin...
  16. ncbi Radioimmunodetection of head and neck cancer. A review
    E V Hopsu
    Department of Otolaryngology, Helsinki University Central Hospital, Finland
    Acta Oncol 32:735-40. 1993
    ..A review of the clinical trials reported in the literature, and our own results with 111In-labeled anti-carcinoembryonic antigen (CEA) antibody in 42 patients are presented.
  17. ncbi Labeling of monoclonal antibody conjugates with 90Y
    C Motta Hennessy
    Center for Molecular Medicine and Immunology, Newark, NJ 07103
    Int J Rad Appl Instrum A 42:421-6. 1991
    An anti-carcinoembryonic antigen (CEA) antibody, NP-4, was labeled with 90Y using p-isothiocyanatobenzyl DTPA (SCN-Bz-DTPA) and its derivatives 1-(p-isothiocyanatobenzyl)-3-methyl-DTPA (1B3M), 2-(p-isothiocyanatobenzyl)-4-methyl-DTPA (..
  18. ncbi Feasibility of radioimmunoguided surgery of colorectal carcinoma using indium 111 CEA specific antibody and simulation with a phantom using 2 steps targetting with bispecific antibody
    A Hamy
    Clinique Chirurgicale, CHU Nantes, France
    Tumori 81:103-6. 1995
    ..the potential use of radiolabelled (Indium 111 or Technetium 99 m) carcinoembryonic antigen specific antibody (CEA f(ab')2) for the radioimmunodetection of colorectal cancer using an intraoperative hand-held gamma probe...
  19. ncbi [Diagnostic value of the tumor markers TPA-M, CYPFRA 21-1 and CEA in pleural effusion. Prospective comparison of thoracoscopic investigations in patients with pleural effusion]
    U Riedel
    Pneumologische Abt. II, Lungenklinik Heckeshorn, Berlin
    Pneumologie 53:471-6. 1999
    The diagnostic value of tumour markers in pleural effusion is not yet clearly defined. CEA (Carcinoembryonic Antigen), CYFRA 21-1 (Cytokeratin 19-Fragment) and TPA-M, a new monoclonal-based radioimmunoassay for TPA (Tissue Polypeptide ..
  20. ncbi Tumor markers in mammary carcinoma. An evaluation of carcinoembryonic antigen, placental alkaline phosphatase, pseudouridine and CA-50
    T Rasmuson
    Department of Oncology, , Sweden
    Acta Oncol 26:261-7. 1987
    In 104 patients with breast cancer, carcinoembryonic antigen (CEA), placental alkaline phosphatase (PLAP) and the carbohydrate antigen CA-50 were analysed in serum...
  21. ncbi Host markers and prognosis in recurrent rectal carcinomas treated with radiotherapy
    E Hannisdal
    Department of Oncology, Norwegian Radium Hospital, Oslo
    Acta Oncol 33:415-21. 1994
    ..LD), erythrocyte sedimentation rate (ESR), alpha 1-, alpha 2-globulin, fibrinogen, carcinoembryonic antigen (CEA), C-reactive protein (CRP), haptoglobin, granulocytosis and thrombocytosis were the most important ones (p < or =..
  22. ncbi Serum tumor markers for detection of bone metastasis in breast cancer patients
    A Aydiner
    Dept. of Medical Oncology, Istanbul Faculty of Medicine, Turkey
    Acta Oncol 33:181-6. 1994
    ..15-3 (CA 15-3) and 19-9 (CA 19-9), cancer antigen 125 (CA 125), alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), beta-2 microglobulin (BMG), ferritin, and tissue polypeptide antigen (determined by the M3 monoclonal antibody, ..
  23. ncbi Diagnostic potential of carcinoembryonic antigen and ferritine in tuberculous and malignant pleural effusion
    R Loncar
    Central Institute for Tumors and Allied Diseases, Zagreb, Croatia
    Tumori 81:440-4. 1995
    The aim of the study was to determine the diagnostic value of carcinoembryonic antigen (CEA) and ferritine in malignant and tuberculous non-bloody pleural effusion...
  24. ncbi Leukocyte alkaline phosphatase and carcinoembryonic antigen in metastatic colorectal cancer patients
    N Walach
    Department of Oncology, Assaf Harofeh Medical Center, Zerifin, Israel
    Tumori 77:164-6. 1991
    ..hundred percent of the metastatic cancer patients had elevated LAP scores and 73% of these patients had elevated CEA levels...
  25. ncbi Vaginal fluid and serum CEA, CA125 and SCC in normal conditions and in benign and malignant diseases of the genital tract
    A Sarandakou
    Second Department of Obstetrics and Gynecology, Areteion University Hospital, Athens, Greece
    Acta Oncol 36:755-9. 1997
    Carcinoembryonic antigen (CEA), CA125, and squamous cell carcinoma antigen (SCC) were evaluated in paired vaginal fluid and serum samples from 69 women, mean age 40.6 (20-78) years...
  26. ncbi Determination of carcinoembryonic antigen levels in peripheral and draining venous blood in patients with colorectal carcinoma
    Jaques Waisberg
    Surgical Gastroenterology, Hospital do Servidor Publico Estadual, Sao Paulo, SP, Brazil
    Arq Gastroenterol 41:88-92. 2004
    The problem of the relationship between blood carcinoembryonic antigen (CEA) levels and tissue CEA content in colorectal carcinoma, and the mechanisms for CEA release from tumor cells in tissue adjacent to the neoplasm is important to ..
  27. ncbi Imaging of tumours in the parotid region with indium-111 labelled monoclonal antibody reacting with carcinoembryonic antigen
    K J Kairemo
    Division of Nuclear Medicine, Helsinki University Central Hospital, Finland
    Acta Oncol 29:539-43. 1990
    ..gland region were examined by planar scintigraphy at 22-28 h after injection of 111In-labelled monoclonal anti-CEA-antibody. Two patients were also examined with emission tomography...
  28. ncbi Simultaneous determination of alpha-fetoprotein and carcinoembryonic antigen in human serum by time-resolved fluoroimmunoassay
    K Matsumoto
    Department of Chemistry, Waseda University, Shinjuku ku, Japan Science and Technology Corporation, Tokyo, 169 8555, Japan
    Anal Biochem 276:81-7. 1999
    A novel simultaneous measurement method for alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in human sera by time-resolved fluoroimmunoassay (TR-FIA) is described...
  29. ncbi Carcinoembryonic antigen in anal carcinoma
    G Tanum
    Norwegian Radium Hospital, Oslo
    Acta Oncol 31:333-5. 1992
    ..squamous cell carcinoma of the anal canal occasionally present with an elevated level of carcinoembryonic antigen (CEA) in serum. The present study was performed to evaluate the clinical importance of this observation...
  30. ncbi Immunohistochemical demonstration of carcinoembryonic antigen and related antigens in various cutaneous keratinous neoplasms and verruca vulgaris
    K Egawa
    Department of Dermatology, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860, Japan
    Br J Dermatol 139:178-85. 1998
    Carcinoembryonic antigen (CEA), which is a well-known marker for the normal sweat gland apparatus and its neoplasms in the skin, was recently demonstrated in sebaceous neoplasms...
  31. ncbi Regulation of cytokine production in carcinoembryonic antigen stimulated Kupffer cells by beta-2 adrenergic receptors: implications for hepatic metastasis
    Peter Thomas
    Laboratory of Surgical Biology, Department of Surgery, Boston University School of Medicine, 801 Albany St, S310, Boston, MA 02118, USA
    Cancer Lett 209:251-7. 2004
    Elevated Carcinoembryonic antigen (CEA) levels in the serum indicate a poor prognosis for colorectal cancer patients...
  32. pmc Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers
    Veronique Garambois
    INSERM, EMI0227 Centre de Recherche en Cancérologie, CRLC Val d Aurelle Paul Lamarque, F 34298 Cedex 5 Montpellier, France
    BMC Cancer 4:75. 2004
    ..Carcinoembryonic antigen (CEA) being the reference antigen for immunotargeting of these tumors, we developed human anti-CEA MAbs.
  33. ncbi Vaccine-based therapy directed against carcinoembryonic antigen demonstrates antitumor activity on spontaneous intestinal tumors in the absence of autoimmunity
    John W Greiner
    Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 62:6944-51. 2002
    By virtue of its tissue-specific expression, carcinoembryonic antigen (CEA) is an important self, tumor-associated antigen, which is expressed by different human adenocarcinomas and also serves as a target for active-specific ..
  34. ncbi Utility of slot-blot-ELISA as a new, fast, and sensitive immunoassay for detection of carcinoembryonic antigen in the urine samples of patients with various gastrointestinal malignancies
    Samir El-Masry
    Molecular and Cellular Biology Department, Genetic Engineering and Biotechnology Research Institute, Minufiya University, Sadat City, Minufiya, Egypt
    J Immunoassay Immunochem 28:91-105. 2007
    Carcinoembryonic antigen (CEA) is the most widely used clinical tumor marker. CEA immunoassay has found acceptance as a diagnostic adjunct in clinical diagnosis of gastrointestinal tumors (GIT)...
  35. ncbi Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas
    John L Marshall
    Lombardi Cancer Center, Georgetown University Medical Center, 3800 Reservoir Rd, NW, Washington, DC 20007, USA
    J Clin Oncol 23:720-31. 2005
    ..Our previous clinical experience with vaccinia and replication-defective avipox recombinant carcinoembryonic antigen (CEA) vaccines has demonstrated safety and clinical activity with a correlation between CEA-specific immune response and ..
  36. pmc A phase I study of a combination of yttrium-90-labeled anti-carcinoembryonic antigen (CEA) antibody and gemcitabine in patients with CEA-producing advanced malignancies
    Stephen Shibata
    City of Hope, Duarte, California 91010, USA
    Clin Cancer Res 15:2935-41. 2009
    To determine the maximum tolerated dose of combined therapy using an yttrium-90-labeled anti-carcinoembryonic antigen (CEA) antibody with gemcitabine in patients with advanced CEA-producing solid tumors.
  37. ncbi Immunogenicity of the carcinoembryonic antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma patients
    Pedro M S Alves
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, Hopital Orthopedique, HO 05, rue Pierre Decker, 4, 1005, Lausanne, Switzerland
    Cancer Immunol Immunother 56:1795-805. 2007
    Carcinoembryonic antigen (CEACAM5) is commonly overexpressed in human colon cancer. Several antigenic peptides recognized by cytolytic CD8+ T-cells have been identified and used in colon cancer phase-I vaccination clinical trials...
  38. ncbi Immunization with mimotopes prevents growth of carcinoembryonic antigen positive tumors in BALB/c mice
    Kira H Brämswig
    Department of Pathophysiology, Medical University Vienna, Vienna, Austria
    Clin Cancer Res 13:6501-8. 2007
    The carcinoembryonic antigen (CEA) is a glycoprotein that is overexpressed in nearly 50% of all human and veterinarian tumors. At present, anti-CEA antibodies are being tested in clinical studies as passive immunotherapeutics...
  39. ncbi Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors
    Andreas Scorilas
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, ON, Canada
    Gene 310:79-89. 2003
    Carcinoembryonic antigen (CEA) is a complex immunoreactive glycoprotein belonging to a large and heterogeneous group of cross-reacting proteins known as the CEA gene family, which contains 29 genes/pseudogenes...
  40. ncbi Prognostic significance of circulating antibodies against carcinoembryonic antigen (anti-CEA) in patients with colon cancer
    K Albanopoulos
    First Department of Propaedeutic Surgery, Hippocration Hospital, Athens, Greece
    Am J Gastroenterol 95:1056-61. 2000
    OBJECTIVE: The discovery of antibodies against carcinoembryonic antigen (CEA) in patients with digestive cancers, in the late 1970s, initiated a number of studies on the role of these antibodies in patients with cancers of the GI tract...
  41. ncbi Coexpression of carcinoembryonic antigen and E-cadherin in colorectal adenocarcinoma with liver metastasis
    Jin C Kim
    Department of Surgery, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Seoul, South Korea
    J Gastrointest Surg 7:931-8. 2003
    Carcinoembryonic antigen (CEA) has been suggested as a metastatic activator in colorectal carcinoma, whereas the E-cadherin expression is downregulated in a variety of carcinomas...
  42. pmc Species-specific evolution of immune receptor tyrosine based activation motif-containing CEACAM1-related immune receptors in the dog
    Robert Kammerer
    Tumor Immunology Laboratory, LIFE Center, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr, 23, 81377 Munich, Germany
    BMC Evol Biol 7:196. 2007
    ..The CEA (carcinoembryonic antigen) gene family codes for such proteins and indeed shows tremendous species-specific ..
  43. ncbi Streptococcal preparation OK-432 promotes the capacity of dendritic cells (DCs) to prime carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocyte responses induced with genetically modified DCs that express CEA
    Toshiyasu Ojima
    Second Department of Surgery, Wakayama Medical University, School of Medicine, 811 1 Kimidera, Wakayama 641 8510, Japan
    Int J Oncol 32:459-66. 2008
    ..In this study, we established carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes (CTLs) using in vitro stimulation with adenovirally modified human DCs that ..
  44. ncbi A prospective study of 2-[18F] fluoro-2-deoxy-D-glucose/positron emission tomography scan, 99mTc-labeled arcitumomab (CEA-scan), and blind second-look laparotomy for detecting colon cancer recurrence in patients with increasing carcinoembryonic antigen le
    S K Libutti
    Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1502, USA
    Ann Surg Oncol 8:779-86. 2001
    An increasing carcinoembryonic antigen (CEA) level in the absence of disease on imaging studies can present a diagnostic challenge...
  45. ncbi The adhesion and differentiation-inhibitory activities of the immunoglobulin superfamily member, carcinoembryonic antigen, can be independently blocked
    Maryam Taheri
    McGill Cancer Centre and Departments of Biochemistry and Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 278:14632-9. 2003
    ..Human carcinoembryonic antigen (CEA), an Ig superfamily cell surface glycoprotein used widely as a clinical tumor marker, undergoes homophilic ..
  46. ncbi Carcinoembryonic antigen in the staging and follow-up of patients with colorectal cancer
    Mitchell J Goldstein
    Division of Neoplastic Diseases, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Invest 23:338-51. 2005
    b>CEA is a complex glycoprotein produced by 90% of colorectal cancers and contributes to the malignant characteristics of a tumor. It can be measured in serum quantitatively, and its level in plasma can be useful as a marker of disease...
  47. ncbi Effective production of carcinoembryonic antigen by conversion of the membrane-bound into a recombinant secretory protein by site-specific mutagenesis
    Fakhraddin Naghibalhossaini
    Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran
    Pathol Oncol Res 11:211-7. 2005
    Carcinoembryonic antigen (CEA), the most widely used human tumor marker, is a heavily glycosylated protein over-expressed by a wide range of tumors...
  48. ncbi Preoperative carcinoembryonic antigen and albumin in predicting survival in patients with colon and rectal carcinomas
    Teeranut Boonpipattanapong
    Faculty of Medicine, Department of Surgery, Songklanagarind Hospital, Prince of Songkla University, Hatyai, Songkla, Thailand
    J Clin Gastroenterol 40:592-5. 2006
    ..between postoperative outcomes of colorectal carcinoma patients and preoperative serum carcinoembryonic antigen (CEA) and albumin (ALB) levels and evaluate if these levels can accurately predict outcomes and/or be factor indicating ..
  49. doi A comparison of tumour M2-PK with carcinoembryonic antigen and CA19-9 in patients undergoing liver resection for colorectal metastases
    Yogesh Kumar
    University Department of Surgery, HPB and Liver Transplant Unit, Royal Free Hospital, Royal Free and University College Medical School, University College London, London, UK
    Eur J Gastroenterol Hepatol 20:1006-11. 2008
    ..This study has measured TuM2-PK levels in patients before and after resection of colorectal liver metastases (CLM)...
  50. doi Late administration of plasmid DNA by intradermal electroporation efficiently boosts DNA-primed T and B cell responses to carcinoembryonic antigen
    Andreas Brave
    Department of Virology, Swedish Institute for Infectious Disease Control, Stockholm, Sweden
    Vaccine 27:3692-6. 2009
    ..We have previously shown that administration of recombinant carcinoembryonic antigen (CEA) efficiently boosts humoral responses in mice primed with CEA DNA...
  51. ncbi Carcinoembryonic antigen gene and carcinoembryonic antigen expression in the liver metastasis of colorectal carcinoma
    J C Kim
    Department of Surgery, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Seoul, Korea
    Mol Cells 9:133-7. 1999
    The presence of the carcinoembryonic antigen (CEA) gene and CEA expression in the liver was tested to identify their possible roles in the liver metastasis of colorectal carcinoma...
  52. ncbi An evaluation of the tumour markers, carcinoembryonic antigen (CEA), cytokeratin marker (CYFRA 21-1) and neuron-specific enolase (NSE) in the differentiation of malignant from benign solitary pulmonary lesions
    M D Seemann
    Department of Diagnostic Radiology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Lung Cancer 26:149-55. 1999
    The aim of this prospective study was to assess the diagnostic value of the tumour markers carcinoembryonic antigen (CEA), cytokeratin 19 fragment marker (CYFRA 21-1) and neuron-specific enolase (NSE) in the differentiation of malignant (..
  53. ncbi Phase I study in advanced cancer patients of a diversified prime-and-boost vaccination protocol using recombinant vaccinia virus and recombinant nonreplicating avipox virus to elicit anti-carcinoembryonic antigen immune responses
    J L Marshall
    Georgetown University Medical Center, Vincent T Lombardi Cancer Center, Washington, DC 20007, USA
    J Clin Oncol 18:3964-73. 2000
    ..This trial sought to determine, for the first time, the validity in human vaccinations of using two different recombinant vaccines in diversified prime-and-boost regimens to enhance T-cell responses to a tumor antigen...
  54. ncbi A re-evaluation of carcinoembryonic antigen (CEA) as a serum marker for breast cancer: a prospective longitudinal study
    F Guadagni
    Laboratory of Clinical Pathology, Regina Elena Cancer Institute, Via Chianesi 53, 00144 Rome, Italy
    Clin Cancer Res 7:2357-62. 2001
    Carcinoembryonic antigen (CEA) is still a widely used test for monitoring breast cancer, although recent reports discourage its routine use because of low sensitivity. This is a prospective study evaluating the efficacy of CEA and CA 15...
  55. ncbi Serum cytokeratin fragment 21.1 (CYFRA 21.1) as tumour marker for breast cancer: comparison with carbohydrate antigen 15.3 (CA 15.3) and carcinoembryonic antigen (CEA)
    Luca Giovanella
    Laboratory of Endocrinology and Oncology, University Hospital Ospedale di Circolo e Fondazione Macchi, Varese, Italy
    Clin Chem Lab Med 40:298-303. 2002
    Serum carbohydrate antigen 15.3 (CA 15.3) and carcinoembryonic antigen (CEA) are currently employed in clinical practice as markers for breast cancer, particularly in the follow-up and therapy monitoring...
  56. ncbi Carcinoembryonic antigen-producing cell-specific oncolytic adenovirus, OV798, for colorectal cancer therapy
    Yuanhao Li
    Cell Genesys, Inc, South San Francisco, CA 94080, USA
    Mol Cancer Ther 2:1003-9. 2003
    Human carcinoembryonic antigen (CEA) is overexpressed in most colorectal cancers and has been widely used as a clinical marker for the management of colon cancer patients...
  57. ncbi Successful cancer vaccine therapy for carcinoembryonic antigen (CEA)-expressing colon cancer using genetically modified dendritic cells that express CEA and T helper-type 1 cytokines in CEA transgenic mice
    Toshiyasu Ojima
    Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
    Int J Cancer 120:585-93. 2007
    ..the vaccination of genetically modified dendritic cells (DCs) simultaneously expressing carcinoembryonic antigen (CEA), granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 12 (IL-12) can overcome the peripheral ..
  58. ncbi Diagnostic accuracy of serum-carcinoembryonic antigen in recurrent colorectal cancer: a receiver operating characteristic curve analysis
    Hartwig Körner
    Department of Surgery, Stavanger University Hospital, P O Box 8100, 4068, Stavanger, Norway
    Ann Surg Oncol 14:417-23. 2007
    Serial measurements of carcinoembryonic antigen (CEA) are frequently used in the follow-up after colorectal cancer (CRC), but its usefulness remains debatable...
  59. ncbi Prognostic value of carcinoembryonic antigen and CYFRA21-1 in patients with pathological stage I non-small cell lung cancer
    Katsunari Matsuoka
    Department of Thoracic Surgery, Japanese Red Cross Society Wakayama Medical Center, Japan
    Eur J Cardiothorac Surg 32:435-9. 2007
    ..of this retrospective study was to assess the prognostic value of serum tumor markers (carcinoembryonic antigen (CEA) and CYFRA21-1) in patients with pathologic (p-) stage I non-small cell lung cancer (NSCLC) undergoing complete ..
  60. ncbi Multinucleated giant stromal tumor of the omentum: report of a case with immunohistochemical and ultrastructural investigation
    K W Min
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Ultrastruct Pathol 20:89-99. 1996
    ..positive for actin along the periphery of the cytoplasm, and negative for cytokeratin, EMA, myoglobin, S-100, CEA, Factor XIIIa, HMB-45, and HAM56 and KP-1...
  61. ncbi Characterization of murine carcinoembryonic antigen gene family members
    F Rudert
    Institut fur Immunbiologie, Universitat Freiburg, FRG
    Mamm Genome 3:262-73. 1992
    The carcinoembryonic antigen (CEA) is a human tumor marker whose gene belongs to a family with more than 20 members...
  62. ncbi Serum carcinoembryonic antigen level in surgically resected clinical stage I patients with non-small cell lung cancer
    Noriyoshi Sawabata
    Division of Surgery, Toneyama National Hospital, Toyonaka, Osaka, Japan
    Ann Thorac Surg 74:174-9. 2002
    There is little general agreement concerning the effectiveness of serum carcinoembryonic antigen (CEA) as a prognostic indicator for non-small cell lung cancer (NSCLC) in clinical stage I patients...
  63. ncbi Preoperative serum levels of the carcinoembryonic antigen in hereditary non-polyposis colorectal cancer compared to levels in sporadic colorectal cancer
    Uwe Schiemann
    Medizinische Klinik, Munchen, Germany
    Cancer Detect Prev 29:356-60. 2005
    Carcinoembryonic antigen (CEA) serves as the most widely used and most cost-effective tumor marker in colorectal cancer for almost 30 years...
  64. ncbi Carcinoembryonic antigen-stimulated THP-1 macrophages activate endothelial cells and increase cell-cell adhesion of colorectal cancer cells
    Cary B Aarons
    Department of Surgery, Boston University School of Medicine, Boston, MA 02118, USA
    Clin Exp Metastasis 24:201-9. 2007
    ..by colorectal cancer, and numerous studies have shown a relationship between serum carcinoembryonic antigen (CEA) levels and metastasis to this site...
  65. pmc Prognostic significance of serum and tissue carcinoembryonic antigen in patients with gastric adenocarcinomas
    Seong Hoon Park
    Department of Surgery, Kyungpook National University Hospital, Daegu, Korea
    Cancer Res Treat 40:16-21. 2008
    PURPOSE: Carcinoembryonic antigen (CEA) is known to be elevated in nearly all solid malignancies. The prognostic role of CEA in gastric cancers however, is still controversial...
  66. doi Lead time of carcinoembryonic antigen elevation in the postoperative follow-up of colorectal cancer did not affect the survival rate after recurrence
    Chin Hsin Chen
    Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan, Republic of China
    Int J Colorectal Dis 25:567-71. 2010
    The role of carcinoembryonic antigen (CEA) in the early detection of recurrence during the postoperative follow-up of colorectal cancer remains unclear...
  67. doi The impact of carcinoembryonic antigen flare in patients with advanced colorectal cancer receiving first-line chemotherapy
    A S Strimpakos
    Department of Medicine, Royal Marsden Hospital, London and Surrey, UK
    Ann Oncol 21:1013-9. 2010
    Carcinoembryonic antigen (CEA) flare may have a favourable response to chemotherapy, but its impact on survival is unknown...
  68. ncbi [Tumor markers in the diagnosis of pancreatic cancer]
    G Cappelli
    U.O. Medicina Nucleare, Azienda Ospedaliera Careggi, Firenze, Italia
    Tumori 85:S19-21. 1999
    ..1 but they are not better than CA 19-9. The use of a "triplet" of tumor markers as CA 19-9, CA 125 and CEA is the best diagnostic tool for cancer of pancreas in an "integrated" use with ultrasonographic evaluation of the ..
  69. ncbi Myoepithelial carcinoma arising in a benign myoepithelioma: immunohistochemical, ultrastructural, and flow-cytometrical study
    J A Bombi
    Department of Pathology, Universitat de Barcelona, Spain
    Ultrastruct Pathol 20:145-54. 1996
    ..2, and were negative for GFAP, muscle-specific actin, CEA, and desmin. Flow cytometry showed a change in the DNA content profile...
  70. ncbi Malignant epithelial mesothelioma of the peritoneum: observations on a problem case
    B P Eyden
    Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, UK
    Ultrastruct Pathol 20:337-44. 1996
    ..Immunohistochemistry gave positive results for Ber-EP4, LeuM1, and CEA, markers, favoring carcinoma...
  71. ncbi Establishment and characterization of a cell line HR-8348 derived from human poorly differentiated adenocarcinoma of rectum
    Z X Zhang
    Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou
    Sci Sin B 30:522-32. 1987
    ..Chromosomal analysis reveals a mode of 70 chromosomes per cell, with a marker chromosome. CEA in cells is detected positively both qualitatively and quantitatively...
  72. ncbi Radioimmunoguided surgery: clinical experience with different monoclonal antibodies and methods
    V Di Carlo
    Department of Surgery, University of Milano, S. Raffaele Hospital, Italy
    Tumori 81:98-102. 1995
    ..With the new method, based on the avidin-biotin binding, it is possible to use anti-Cea MoAbs and to reduce the preoperative waiting time, injecting biotinylated MoAbs and avidin...
  73. ncbi Atypical carcinoid tumor of the larynx: an immunohistochemical, ultrastructural, and flow cytometric analysis
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Ultrastruct Pathol 21:431-8. 1997
    ..2, CEA, chromogranin A, and calcitonin...
  74. ncbi Enhanced uptake of intra-arterially injected anti-CEA monoclonal antibodies in human colonic cancer after mannitol infusion in an experimental model
    H Ahlstrom
    Department of Diagnostic Radiology, Akademiska sjukhuset, University of Uppsala, Sweden
    Acta Oncol 26:453-8. 1987
    ..a.) with 125I-labelled anti-carcinoembryonic (anti-CEA) monoclonal antibodies. The i.a...
  75. ncbi Reversal of resistance to doxifluridine and fluorouracil in metastatic colorectal cancer: the role of high-dose folinic acid
    M Colleoni
    Division of Medical Oncology B, Istituto Nazionale Tumori, Milan, Italy
    Tumori 78:258-61. 1992
    ..In 5 cases a significant decrease in baseline CEA values was observed. Therapy was well tolerated, and no grade 4 toxicity was encountered...
  76. ncbi The spatial distribution of parenterally administered monoclonal antibodies against CEA in a human colorectal tumour xenograft
    H Ahlstrom
    Department of Diagnostic Radiology, Uppsala University, Sweden
    Acta Oncol 28:81-6. 1989
    ..125I-labelled anti-carcinoembryonic (anti-CEA) monoclonal antibodies were injected either intra-arterially after a bolus injection of mannitol, or intra-..
  77. ncbi Radioimmunoimaging of non-small cell lung cancer with 111In- and 99mTc-labeled monoclonal anti-CEA-antibodies
    K J Kairemo
    Department of Clinical Chemistry, Helsinki University Central Hospital, Finland
    Acta Oncol 32:771-8. 1993
    Radiolabeled monoclonal anti-CEA antibodies were used for radioimmunolocalization (RIL) of non-small cell lung cancer; in 30 patients with 111In labeled anti CEA F(ab')2 fragment (BW 431/31) and in 16 with 99mTc-labeled intact MoAb (BW ..
  78. ncbi Comparative ultrastructural study of atypical adenomatous hyperplasia and adenocarcinoma of the human lung
    M Mori
    Department of Pathology, Tohoku University, Sendai, Japan
    Ultrastruct Pathol 22:459-66. 1998
    ..the results of immunohistochemical studies for surfactant apoprotein A, urine protein 1, cytochrome P-450s, CEA, p53, c-erbB-2, Ki67, and bcl-2 well reflected the ultrastructural findings...
  79. ncbi Subepithelial basement membrane deposition and intermediate filament expression in choroid plexus neoplasms and ependymomas
    P N Furness
    Department of Histopathology, University Hospital, Nottingham, UK
    Histopathology 16:251-5. 1990
    ..cytokeratin and glial fibrillar acidic protein (GFAP) and the epithelial marker carcino-embroyonic antigen (CEA) was also assessed...
  80. ncbi A putative mechanism for the non-specific uptake of intact radiolabelled monoclonal antibodies in the testes and prostate
    K E Ahlström
    Department of Diagnostic Radiology, Umea University, Umea, Sweden
    Acta Oncol 35:303-7. 1996
    Non-specific testicular accumulation of radiolabelled intact anti-CEA monoclonal antibody (MAb), (A431/26, Behringwerke AG) was observed in 11 out of 12 patients with the testes and prostate included in the examination field at ..
  81. ncbi Image subtraction analysis with technetium-99M labeled monoclonal antibody and colloid for evaluation of liver lesions. Phantom measurements and patient studies
    K J Kairemo
    Department of Clinical Chemistry, Helsinki University Central Hospital, Finland
    Acta Oncol 32:763-9. 1993
    ..technique was applied in 32 breast and lung cancer patients after injecting about 1,000 MBq 99mTc-labeled anti-CEA MoAb; 24 h after the antibody injection 75 MBq 99mTc-phytate was injected...
  82. ncbi [Leu-M1, CEA and intermediate filament proteins in histochemical differential diagnosis of malignant pleural mesothelioma]
    M Heckmayr
    Pneumologisch-Onkologische Abteilung, Krankenhaus Grosshansdorf
    Pneumologie 44:618-9. 1990
    ..Pleuramesotheliomas are Leu-M1 negative. Intermediary filament proteins, CEA and Leu-M1 are important "markers" in the diagnosis of malignant pleuraneoplasias...
  83. ncbi [Pulmonary blastoma. Immunohistochemical characterization of heteromorphic tumor components]
    M Brockmann
    ,
    Pneumologie 44:605-6. 1990
    ..It was not possible to label any tumour cells with the antibodies anti-beta-HCG, anti-NSE, anti-lysozyme or anti-CEA. The negative response of the CEA reaction can be useful for the differentiation from pulmonary adenocarcinoma, in ..
  84. ncbi Tumor markers in serum of patients with primary squamous cell carcinoma of the esophagus
    M Gion
    Division of Radiotherapy, Regional General Hospital, USSL, Venice, Italy
    Tumori 75:489-93. 1989
    ..Three markers specific for digestive tract malignancies--CEA, CA19.9 and CA50--and two non organ specific indicators of malignancy--ferritin and TPA--were evaluated...
  85. ncbi The Danish Breast Cancer Group (DBCG) biochemical tumor marker program
    P Winkel
    Department of Clinical Chemistry KK, Rigshospitalet, Copenhagen, Denmark
    Acta Oncol 27:611-5. 1988
    ..Such a model is presented and its application for the assessment of the usefulness of 14 common tumor markers reviewed. Only P-CEA proved to be of any value but its usefulness was marginal.
  86. ncbi Fluorouracil plus folinic acid in metastatic adenocarcinoma of unknown primary site suggestive of a gastrointestinal primary
    F Nole
    Division of Medical Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 79:116-8. 1993
    ..The results of treatment strategies for carcinoma of an unknown primary location have been discouraging. Currently, no chemotherapeutic approach can be considered standard...
  87. ncbi Duct-acinar-islet cell tumor of the pancreas
    A Nonomura
    Pathology Section, Kanazawa University Hospital, Japan
    Ultrastruct Pathol 16:317-29. 1992
    ..of the tumor; they were positive for mucin and immunoreactive for cytokeratin and carcinoembryonic antigens (CEA). The acinar component was the minor element of the tumor in both cases...
  88. ncbi Bladder tumor markers: need, nature and application. 2. Tumor and tumor-associated antigens
    M M Kirollos
    Urology Department, Torbay Hospital, South Devon Health Care Trust, UK
    Int Urogynecol J Pelvic Floor Dysfunct 9:228-35. 1998
    ..Some of the markers used, such as hCG and CEA, are far better known in other fields and seem to be expressed in only a minority of urothelial tumors...
  89. ncbi Leukocyte alkaline phosphatase, CA15-3, CA125, and CEA in cancer patients
    N Walach
    Department of Oncology, Assaf Harofeh Medical Center, Zerifin, Israel
    Tumori 84:360-3. 1998
    Peripheral blood leukocyte alkaline phosphatase (LAP) scores and CA15-3, CA125, and CEA levels in plasma were measured in 57 patients with metastatic breast, ovarian, and colorectal cancer, respectively, and in 79 patients with the same ..
  90. ncbi [CEA as a tumor marker on the cell surface and in the exudate. Comparison in thoracoscopy examined pleural effusions]
    H Grosser
    Lungenklinik Heckeshorn, Berlin
    Pneumologie 44:529-30. 1990
    A prospective comparison was conducted in 43 patients to assess comparatively the ranking of cytology and CEA determined in the pleural effusions and by immunocytology on the cell surface (the latter two compared with each other) and ..
  91. ncbi Radioimmunolocalization of hepatic metastases and subcutaneous xenografts from a human colonic cancer in the nude rat. Aspects of tumour implantation site and mode of antibody administration
    A Sundin
    Department of Diagnostic Radiology, Uppsala University, Sweden
    Acta Oncol 32:877-85. 1993
    ..p.) or intravenous (i.v.) injection of the 125I-labelled anti-CEA-MAb I-38S1 in 44 nude rats, in order to evaluate the influence of tumour implantation site and the route of MAb ..
  92. ncbi Recent achievements in the development of radiolabeled monoclonal antibodies for diagnosis, therapy and biologic characterization of human tumors
    S M Larson
    Nuclear Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, NY
    Acta Oncol 32:709-15. 1993
    ..Tumors which are otherwise occult, particularly for colorectal (anti-CEA and anti-TAG-72 antibodies) and ovarian cancer (anti-TAG-72 and anti-HMFG), are detected in a significant fraction ..
  93. ncbi Suspected extragonadal germ-cell cancer syndrome presenting with an orbital mass and elevation of serum CEA, CA 19-9 and CA50 levels
    J J Cruz
    Department of Oncology, University Hospital, Salamanca, Spain
    Tumori 81:378-80. 1995
    ..We report the case of a young man presenting an orbital tumor and high serum levels of CEA, CA 19-9 and CA50 for whom an initial diagnosis of metastatic poorly differentiated carcinoma was made...
  94. ncbi Evaluation of the circulating glycoprotein CA549 in mammary cancer and other malignancies
    L Clocchiatti
    Divisione di Oncologia Medica, Ospedale Civile di Udine, Italy
    Tumori 77:395-8. 1991
    ..For comparison, CEA and CA15-3 were also investigated. The CA549 cutoff was 11 U/ml...
  95. ncbi Adenoid cystic carcinoma of sweat glands: report of two cases
    C Urso
    Istituto di Anatomia e Istologia Patologica, , Italy
    Tumori 77:264-7. 1991
    ..Histologically, the neoplasms showed the classic appearance of ACC. CEA, actin and S-100 protein were immunocytochemically demonstrated to be contained in some neoplastic cells...
  96. ncbi [Modeling of the relation between plasma concentration of the active metabolite of perindopril and inhibition of the activity of plasma converting enzyme in healthy volunteers]
    E Bellissant
    Service de Pharmacologie Clinique, ,
    Arch Mal Coeur Vaiss 83:1285-9. 1990
    ..Cp) of perindoprilat (P), the active metabolite of perindopril, and plasma converting enzyme activity (CEA) after a single oral administration of perindopril...
  97. ncbi Plasma and tissue CEA and TPA markers in operable breast cancer. Preliminary results
    G Saccani Jotti
    Istituto di Anatomia ed Istologia Patologica, , Italia
    Tumori 74:681-8. 1988
    b>CEA and TPA were studied in sera and in histologic specimens of 200 patients with benign (77) or malignant (123) breast pathology. The frequency and expression of the two markers was different in benign and in cancer tissues...
  98. ncbi [Immunohistochemical markers in lung tumors--a status evaluation]
    K M Muller
    Institut fur Pathologie, Berufsgenossenschaftlichen Krankenanstalten Bergmannsheil, Universitatsklinik, Bochum
    Pneumologie 45:140-6. 1991
    ..most informative parameter in adenocarcinomas was the distinguished expression of the carcino embryonic antigen (CEA)...
  99. ncbi Immunoscintigraphy in laryngeal and pharyngeal carcinomas using indium-111 labelled monoclonal antibody
    K J Kairemo
    Division of Nuclear Medicine, Helsinki University Central Hospital, Finland
    Acta Oncol 29:533-8. 1990
    ..of squamous cell or adenocarcinoma was determined with radioimmunoscintigraphy using monoclonal radiolabelled anti-CEA-antibody. In 12 of the 13 cases, immunohistochemical stainings were positive for CEA...
  100. ncbi Tumour therapy with Vinca alkaloids targeted by a hybrid-hybrid monoclonal antibody recognising both CEA and Vinca alkaloids
    J R Corvalan
    Lilly Research Centre, Windlesham, Surrey, UK
    Int J Cancer Suppl 2:22-5. 1988
    The functional properties of a hybrid-hybrid monoclonal antibody (MAb) recognising both CEA and Vinca alkaloids have been explored in vivo in nude mice xenografted with MAWI, a human colorectal tumour...
  101. ncbi Serum soluble interleukin-2 receptor in colorectal cancer
    S Murakami
    Second Department of Surgery, Saitama Medical School, Japan
    Acta Oncol 33:19-21. 1994
    ..cancer, and correlated with various factors as stage, lymph node metastasis, liver metastasis, grade, serum CEA and IAP (immunosuppressive acidic protein)...

Research Grants65

  1. A MACROPHAGE PROTEIN IN COLON TUMORIGENESIS
    Aniruddha Ganguly; Fiscal Year: 2001
    Carcinoembryonic antigen (CEA) is an intercellular adhesion molecule that plays a major role in colon tumorigenesis. We have identified a novel protein on human monocytes that binds to CEA...
  2. Mechanism of Cognitive Dysfunction: CEA and Stenting
    ERIC JOHN HEYER; Fiscal Year: 2012
    ....
  3. Carotid angioplasty and stenting in the elderly
    Brahmajee Nallamothu; Fiscal Year: 2009
    ..provided by applicant): Each year approximately 100,000 elderly Americans undergo carotid endarterectomy (CEA) to reduce their risk of stroke and death...
  4. Robert Harris; Fiscal Year: 2015
    ..To further increase the specificity, we will take advantage of the expression of carcinoembryonic antigen (CEA) by colorectal cancer cells and have designed an AAV2 vector where hNMNAT2 is driven by CEA...
  5. Victor C Yang; Fiscal Year: 2015
    ..First, carcinoembryonic antigen (CEA), a surface antigen known to associate with tumor growth/metastasis, was shown to be overly expressed in colonic ..
  6. METASTATIC POTENTIAL OF COLORECTAL CARCINOMA
    Lopa Mishra; Fiscal Year: 2010
    ..host liver as arresting tumor cells create an ischemia/reperfusioninjury, 2) CRC release Carcinoembryonic Antigen (CEA), a 180 kDa glycoprotein, that binds to heterogeneous RNA-binding protein M4 on Kupffer cells (the CEA receptor or ..
  7. Comparative Effectiveness of Treatment Options for Asymptomatic Carotid Disease
    Steven D Pizer; Fiscal Year: 2013
    ..Impacts on Veterans'Healthcare At the present time it is not known how many carotid endarterectomy (CEA) procedures are performed in the VA on patients with asymptomatic carotid disease and how many are performed on ..
  8. Salomeh Keyhani; Fiscal Year: 2016
    ..provided by applicant): Randomized controlled trials (RCTs) have established that carotid endarterectomy (CEA) is superior to medical therapy in preventing stroke in both asymptomatic and symptomatic patients with carotid ..
  9. PET/MRI of atherosclerosis
    Chun Yuan; Fiscal Year: 2012
    ..micro-PET imaging to establish a gold standard of localized signal in ex vivo carotid endarterectomy (CEA) specimens...
  10. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..Tumor cells expressing model tumor antigens, such as, ovalbumin (OVA) and carcinoembryonic antigen (CEA) will be used in these studies...
  11. Evanthia Galanis; Fiscal Year: 2014
    ..into the first human clinical trial of a measles virus derivative producing human carcinoembryonic antigen, MV-CEA (CEA added to facilitate viral monitoring) in recurrent GBM patients...
  12. Peter Thomas; Fiscal Year: 2014
    ..is to examine how ethanol exposure can lead to altered processing and degradation of carcinoembryonic antigen (CEA), a glycoprotein secreted by tumor cells, and whose increase in the circulation has been linked to increased ..
  13. Optimizing Measles Virotherapy in the Treatment of Ovarian Cancer
    Kah Whye Peng; Fiscal Year: 2012
    ..approach into a phase I clinical trial of a measles virus derivative producing human carcinoembryonic antigen, MV-CEA (CEA added to facilitate monitoring of viral gene expression) in recurrent ovarian cancer patients...
  14. Histopathologic and Immunohistochemical Features of Tissue Adherent to the Electr
    CONSTANTINOS THASOS SOFOCLEOUS; Fiscal Year: 2011
    ..to the electrode and obtained with needle biopsy) with peripheral blood levels of carcinoembryonic antigen (CEA)...
  15. Therapeutic Vaccine for HIV/HPV-associated Oropharyngeal and Tonsillar Malignanci
    FRANK R JONES; Fiscal Year: 2011
    ..In a murine cancer model employing the carcinoembryonic antigen (CEA) gene insert, tl...
  16. Defining Secreted Glycan Alterations in Pancreatic Cancer
    Brian B Haab; Fiscal Year: 2010
    ..The sensitivity and specificity of detecting pancreatic cancer using measurements of glycans on mucins, CEA proteins, and proteins identified in the R33 phase will be characterized in a large set of serum samples from ..
  17. Development of a Novel CEA Expressing Ad5 [E1-, E2b-] Vector for Treatment
    FRANK R JONES; Fiscal Year: 2010
    ..by applicant): The objective of this project is to continue to develop an adenoviral vector vaccine against CEA that is effective in stimulating cell-mediated immune responses in subjects previously immune to Adenovirus...
  18. TAS::75 0849 - TOPIC 255 PHASE II, CGMP MANUFACTURE OF A NOVEL CEA EXPRESSING A
    FRANK R JONES; Fiscal Year: 2011
    Etubics Corporation is clinically testing a new vaccine targeting carcinoembryonic antigen (CEA) expressing cancers in a Phase I/II clinical trials under FDA IND14325...
  19. ANTIIDIOTYPE VACCINE THERAPY OF HUMAN COLORECTAL CANCER
    MALAYA CHATTERJEE; Fiscal Year: 2002
    ..a murine monoclonal anti-idiotype ( antibody, 3Hl, that is the internal image of the carcinoembryonic antigen (CEA)...
  20. Cell-type specific targting of curcumin
    BIDDANDA PONNAPPA; Fiscal Year: 2005
    ..Recent studies show that curcumin has both anti-inflammatory and anti-cancer properties. Carcinoembryonic antigen (CEA), a glycosylated protein secreted by tumor cells, has been implicated in the development of hepatic metastasis of ..
  21. Rational Design of Therapeutic Vaccines for CEA+ Tumors
    SUNIL CHATTERJEE; Fiscal Year: 2007
    ..vaccination with an anti-idiotype (Id) antibody (3H1) that mimics an epitope of human carcinoembryonic antigen (CEA) has the potential to augment survival benefits...
  22. ANTIGEN PRESENTATION BY CEA DIRECTED TUMOR VACCINES
    Howard Kaufman; Fiscal Year: 2003
    Carcinoembryonic antigen (CEA) is a common tumor-associated antigen. Several T-cell specific epitopes have been identified within the terminal repeat domains of CEA, suggesting that CEA may be a target for vaccine development...
  23. RADIOIMMUNOTHERAPY OF ADVANCED REFRACTORY OVARIAN CANCER
    Malik Juweid; Fiscal Year: 1999
    ..EOC is known to produce carcinoembryonic antigen (CEA)...
  24. TFF3 GENE EXPRESSION IN METASTATIC COLON CANCER
    Steven Itzkowitz; Fiscal Year: 2001
    ..We have also demonstrated that placing the suicide gene under the control of the carcinoembryonic antigen (CEA) promoter affords greater tissue specificity...
  25. STRUCTURE/FUNCTION OF A HEPATIC CEA BINDING PROTEIN
    Peter Thomas; Fiscal Year: 2000
    Carcinoembryonic antigen (CEA) is involved in the development of hepatic metastases from colorectal cancers. The major hepatic CEA binding protein is 80kD Kupffer cell surface molecule...
  26. RECOMBINANT TUMOR VACCINE--CATBRM
    Albert LoBuglio; Fiscal Year: 1999
    ..The program is currently carrying out a phase Ib trial of recombinant vaccinia-carcinoembryonic antigen (CEA) immunization in resected Dukes' C colorectal cancer patients and a phase I trial of baculovirus recombinant CEA ..
  27. CEA directed cancer treatment with gene-modified T cells
    Mark McKee; Fiscal Year: 2007
    ..his proposed research, he will study the biology and genetics of T cells that recognize carcinoembryonic antigen (CEA)...
  28. CANARYPOX VACCINE EXPRESSIONG CEA AND B7
    Howard Kaufman; Fiscal Year: 1999
    ..Nearly 500,000 patients are diagnosed annually with solid tumors that express carcinoembryonic antigen (CEA)...
  29. Evaluation of the Vaccine rF-CEA(6D)/TRICOM +/-GM-CSF
    Margaret von Mehren; Fiscal Year: 2002
    ..Specifically, a vaccine model vaccinating against the tumor associated antigen carcinoembryonic antigen (CEA) demonstrated an increase in the CEA-specific T-cell response using a vaccine with the three costimulatory ..
  30. CEA DENTRITIC CELL VACCINE FOR COLORECTAL CANCER
    Frank Scappaticci; Fiscal Year: 2002
    ..vaccine in order to elicit a humoral and cell-mediated cytotoxic response against carcinoembryonic antigen (CEA) expressing tumor cells...
  31. 12th International CEA/PSG Symposium
    Douglas Hixson; Fiscal Year: 2001
    This application is being submitted to request partial funding support for the Twelfth International CEA Symposium, to be held July 29- August 1, 2001 in Providence, Rhode Island...
  32. IMMUNOTHERAPY OF CANCER WITH ANTIID BASED DNA VACCINE
    SUNIL CHATTERJEE; Fiscal Year: 1999
    ..Our anti-Id, 3H1, which resembles an epitope of the carcinoembryonic antigen (CEA), acts as a surrogate for CEA, and we have completed a phase Ib trial of colon cancer patients with this anti-Id...
  33. ANTICEA IGTCR MODIFIED T CELLS FOR CANCER THERAPY
    Richard Junghans; Fiscal Year: 2000
    Carcinoembryonic antigen (CEA) is expressed as a tumor-associated antigen in a large number of human malignancies...
  34. FUSION PROTEINS AGAINST CARCINOEMBRYONIC ANTIGEN
    F Primus; Fiscal Year: 2003
    ..for the targeting of cytokines and/or co-stimulatory molecules to tumors expressing carcinoembryonic antigen (CEA) for immunotherapy. These studies will use a high affinity anti-CEA Mab, T84...
  35. JAMES FRANCIS BURKE; Fiscal Year: 2016
    ..to estimate the expected net benefit of carotid endarterectomy (CEA) vs...
  36. Kang Kim; Fiscal Year: 2014
    ..the tissue mimicking phantoms, the human tissue specimens from autopsy, amputation and carotid endarterectomy (CEA), and high cholesterol-fed rabbit model...
  37. Wei Zhou; Fiscal Year: 2015
    ..Carotid endarterectomy (CEA) and stenting (CAS) have shown to be effective in stroke prevention...
  38. Alice J Sheffet; Fiscal Year: 2016
    ..Stenting Trial (CREST) that is designed to establish the relative efficacy of carotid endarterectomy (CEA) versus carotid artery stenting (CAS)...
  39. Neuroimaging Correlates of Memory Decline Following Carotid Interventions
    Wei Zhou; Fiscal Year: 2013
    ..Whereas both carotid endarterectomy (CEA) and carotid stenting (CAS) are effective treatments for stroke prevention in patients with severe carotid ..
  40. Carotid Revascularization Endarterectomy vs Stenting Trial
    Thomas G Brott; Fiscal Year: 2010
    ..However, randomized clinical trial data contrasting the efficacy of CAS and carotid endarterectomy (CEA), the gold standard treatment for carotid atherosclerosis, are not available except in restricted populations...
  41. KARL D WITTRUP; Fiscal Year: 2014
    ..affinity both to chelated metal ions and to tumor antigens (specifically, the colorectal carcinoma antigens A33 or CEA). New data is presented that demonstrates the robust expression and solubility characteristics of the bsAbs...
  42. Subhash C Pandey; Fiscal Year: 2014
    ..of BDNF expression and related signaling pathways, thereby affecting dendritic spines in the central amygdala (CeA) and medial amygdala (MeA), but not in the basolateral amygdala (BLA);and 2) tolerance at the level of BDNF, via ..
  43. Beverley Greenwood-Van Meerveld; Fiscal Year: 2016
    ..amygdala is abnormal in adult rats following ELS, We will also determine whether down regulation of GR or MR in the CeA using antisense oligodeoxynucleotides (ODNs) affects anxiety and colonic hypersensitivity...
  44. Subhash C Pandey; Fiscal Year: 2016
    ..cytoskeleton-associated protein (Arc) expression, and dendritic spine density (DSD) were lower in the central (CeA) and medial nucleus of amygdala (MeA) but not basolateral amygdala (BLA) of P rats as compared with NP rats...
  45. Beverley Greenwood-Van Meerveld; Fiscal Year: 2016
    ..induced by either i) direct application of corticosterone micropellets onto the central nucleus of the amygala (CeA) or ii) repeated water avoidance stress (WAS), we will investigate whether knockdown of amygdaloid gene expression ..
  46. Subhash C Pandey; Fiscal Year: 2016
    ..The extended amygdala, which includes central nucleus of amygdala (CeA), medial nucleus of amygdala (MeA), nucleus accumbens (NAc) shell, and bed nucleus of stria terminalis (BNST) ..
  47. Ned H Kalin; Fiscal Year: 2016
    ..In terms of brain mechanisms, indirect evidence implicates increased central nucleus of the amygdala (CeA) activity and corticotropin-releasing hormone (CRH) system activity as factors underlying the risk to develop ..
  48. ANATOMY AND PHARMACOLOGY OF FEAR-POTENTIATED STARTLE
    MICHAEL NMN DAVIS; Fiscal Year: 2010
    ..whether fear potentiated startle results from activation of GABA containing neurons in the lateral division of the CeA (lateral CeA), which then inhibit GABA containing projection neurons in the medial CeA, thereby disinhibiting the ..
  49. Rong Zhang; Fiscal Year: 2015
    ..Our central hypothesis is that dysregulation of central amygdala (CeA) CRH is responsible for the stress-induced Depression by assessing the genetic and environmental risk factors...
  50. Anantha Shekhar; Fiscal Year: 2016
    ..network functions in 1) the bed nucleus of the stria terminalis (BNST);2) the central nucleus of the amygdala (CeA);and 3) the infralimbic prefrontal cortex (IL) to delay the extinction of conditioned fear...
  51. Scott D Moore; Fiscal Year: 2016
    ..Specific amygdaloid subnuclei, particularly the central amygdala nucleus (CeA) have been identified as part of a functional system essential to mediating the response to many drugs of abuse, ..
  52. Howard J Edenberg; Fiscal Year: 2015
    ..focus on key INIA regions: the shell of the nucleus accumbens (Nac-shell), the central nucleus of the amygdala (CeA), and the ventral tegmental area (VTA);we have microarray data from adult males that show many significant ..
  53. Role of the Central Amygdala in Ghrelin-Mediated Reward-Based Eating Behavior
    Jeffrey M Zigman; Fiscal Year: 2013
    ..we will test the hypothesis that corticotrophin releasing factor (CRF)- producing neurons of the central amygdala (CeA) contribute to ghrelin's actions on reward-based eating...
  54. Garret D Stuber; Fiscal Year: 2016
    ..Even though the central amygdala (CeA) is known to play an important role in stress-induced negative affect after CIA exposure, unknown is the role input ..
  55. Todd E Thiele; Fiscal Year: 2016
    ..drinking is associated with a significant reduction of NPY immunoreactivity in the central nucleus of the amygdala (CeA) and the bed nucleus of the stria terminalis (BNST)...
  56. David J Anderson; Fiscal Year: 2016
    ..is on understanding the function of subpopulations of interneurons located in the central nucleus of the amygdala (CeA), a brain region involved in emotion...
  57. Robert E Taylor; Fiscal Year: 2016
    ..receptor 4 (TLR4) innate immunity receptors, and using specific siRNA vectors infused into the central amygdala (CeA), demonstrated that regulation of binge drinking at this site is mediated by GABAA a2 regulated TLR4 (a2/TLR4 axis)...
  58. Kelly M Dumais; Fiscal Year: 2014
    ..previously found correlations of OT receptor (OTR) densities in the medial amygdala (MeA) and central amygdala (CeA) with social interest...
  59. Phenotypic and Functional Determination of Central Extended Amygdala Cell Groups
    HEIDI E DAY; Fiscal Year: 2010
    ..focuses on a brain area that is part of the central extended amygdala: the central nucleus of the amygdala (CEA). The CEA is involved in a number of responses to fear, stress and anxiety and contains distinct cell populations...
  60. LINDA M RINAMAN; Fiscal Year: 2016
    ..interconnected regions of the paraventricular nucleus of the hypothalamus (PVN), central nucleus of the amygdala (CeA), and anterolateral bed nucleus of the stria terminalis (alBST)...
  61. Kerry J Ressler; Fiscal Year: 2014
    ..However, we provide the first evidence that Tac2, NkB and Nk3, all highly expressed in the central amygdala (CeA, a key substructure for the formation of fear memories) are involved in emotional learning processes...
  62. Jonathan E Ploski; Fiscal Year: 2014
    ..AAV), viral serotypes that maximally infect the rat Basal Lateral and Central nuclei of the Amygdala (BLA and CeA)...
  63. AMYGDALA AMPA GLUR2 DELETION AND OPIOID DEPENDENCE
    Michael J Glass; Fiscal Year: 2010
    ..There is evidence that ionotropic AMPA-type glutamate receptors in the central nucleus of the amygdala (CeA) may be important molecular substrates of opioid dependence...
  64. KRISTEN ELIZABETH PLEIL; Fiscal Year: 2014
    ..that regulate alcohol drinking and anxiety-related behaviors, including the central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST) in the extended amygdala...
  65. AAV-Based Plasmacytoid Dendritic Cell Cancer Vaccine
    Pierre L Triozzi; Fiscal Year: 2010
    ..provided by applicant): The objective is to develop a vaccine approach targeting carcinoembryonic antigen (CEA), an oncofetal antigen expressed by many common cancers...

Patents1

  1. Cea binding agents to reverse cea-mediated tumorigenic effects onhuman cancer cells and uses thereof
    Patent Number: WO2004031238-A2; Date:2004-04-15