CDR1

Summary

Gene Symbol: CDR1
Description: cerebellar degeneration related protein 1
Alias: CDR, CDR34, CDR62A, cerebellar degeneration-related antigen 1, cerebellar degeneration-related protein 1, 34kDa
Species: human

Top Publications

  1. ncbi An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers
    K A Ellis
    Neuropharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Victoria, Australia
    Behav Pharmacol 12:173-82. 2001
  2. ncbi Dementia and work load evaluation of the elderly
    H A Nygaard
    Fyllingsdalen Sykehjem, Bergen, Norway
    Compr Gerontol A 1:65-8. 1987
  3. pmc Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 40:2300-5. 1996
  4. ncbi Analysis of immunoglobulin H gene rearrangement by polymerase chain reaction in primary central nervous system lymphoma
    Johan M Kros
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurosurg 97:1390-6. 2002
  5. doi Characteristics of disc hemorrhage in primary angle-closure glaucoma
    Yu Wen Lan
    Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan
    Ophthalmology 115:1328-33, 1333.e1. 2008
  6. ncbi Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake
    Elaine M Leslie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 69:629-39. 2006
  7. ncbi The Cohen diabetic (non-insulin-dependent) hypertensive rat model. Description of the model and pathologic findings
    A M Cohen
    Department of Medicine, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Am J Hypertens 6:989-95. 1993
  8. doi PAP1 [poly(A) polymerase 1] homozygosity and hyperadenylation are major determinants of increased mRNA stability of CDR1 in azole-resistant clinical isolates of Candida albicans
    Raman Manoharlal
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Microbiology 156:313-26. 2010
  9. pmc A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans
    Alix Coste
    Institute of Microbiology, University Hospital Lausanne, Switzerland
    Genetics 172:2139-56. 2006
  10. ncbi Evolution of blood pressure in patients with Alzheimer's disease: a one year survey of a French Cohort (REAL.FR)
    O Hanon
    Department of Geriatrics, Hopital Broca, 75013 Paris, France
    J Nutr Health Aging 9:106-11. 2005

Research Grants

  1. Andrew D Weinberg; Fiscal Year: 2014
  2. A novel pre-defined CDR library for selection of affinity reagents
    Michael P Weiner; Fiscal Year: 2013
  3. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David R Clemmons; Fiscal Year: 2010
  4. Mucosal Immune Ontogeny and Intestinal Microbiota in Infants
    Edward N Janoff; Fiscal Year: 2010
  5. Role of IG CDR-H3 in Responses to HIV Vaccines
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2013
  6. Mark J Young; Fiscal Year: 2014
  7. Jason T Kimata; Fiscal Year: 2015
  8. Immunoglobulin CDR-H3 and neutralizing antibodies to HIV
    Harry Schroeder; Fiscal Year: 2009
  9. PROTEOLYTIC ANTIBODIES FOR TREATMENT OF PSORIASIS
    ROBERT BALINT; Fiscal Year: 2009
  10. The role of T cell repertoire selection in the NOD mouse model of MOG-induced EAE
    Anthony Quinn; Fiscal Year: 2007

Detail Information

Publications255 found, 100 shown here

  1. ncbi An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers
    K A Ellis
    Neuropharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Victoria, Australia
    Behav Pharmacol 12:173-82. 2001
    ..Twelve healthy young subjects completed the Cognitive Drug Research (CDR) memory battery, following administration of placebo, 900 mg and 1800 mg hypericum (Blackmore's Hyperiforte)...
  2. ncbi Dementia and work load evaluation of the elderly
    H A Nygaard
    Fyllingsdalen Sykehjem, Bergen, Norway
    Compr Gerontol A 1:65-8. 1987
    ..Mental status was estimated by means of the Clinical Dementia Rating scale (CDR), and work load by means of a traditional work load scale...
  3. pmc Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 40:2300-5. 1996
    ..albicans ABC (ATP-binding cassette) transporter gene called CDR1 and of a gene conferring benomyl resistance (BENr), the product of which belongs to the class of major facilitator ..
  4. ncbi Analysis of immunoglobulin H gene rearrangement by polymerase chain reaction in primary central nervous system lymphoma
    Johan M Kros
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurosurg 97:1390-6. 2002
    ..genes by polymerase chain reaction (PCR) to the framework region (FR)3 and FR2 complementarity determining region (CDR)-III and CDR-II of these genes...
  5. doi Characteristics of disc hemorrhage in primary angle-closure glaucoma
    Yu Wen Lan
    Department of Ophthalmology, Mackay Memorial Hospital, Taipei, Taiwan
    Ophthalmology 115:1328-33, 1333.e1. 2008
    ..To analyze the characteristics of disc hemorrhage in primary angle-closure glaucoma (PACG)...
  6. ncbi Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: role of the T-type calcium channel Cacnalpha1G in cadmium uptake
    Elaine M Leslie
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute and National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 69:629-39. 2006
    ..The CdR1-rev cell line was found to have a Cd(2+) uptake and sensitivity level in between that of the CdR1 and MT(-/-) cell ..
  7. ncbi The Cohen diabetic (non-insulin-dependent) hypertensive rat model. Description of the model and pathologic findings
    A M Cohen
    Department of Medicine, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Am J Hypertens 6:989-95. 1993
    ..here a genetic type II diabetic hypertensive model (CDHM) developed by cross breeding the Cohen diabetic rat (CDR) and the SHR...
  8. doi PAP1 [poly(A) polymerase 1] homozygosity and hyperadenylation are major determinants of increased mRNA stability of CDR1 in azole-resistant clinical isolates of Candida albicans
    Raman Manoharlal
    Membrane Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Microbiology 156:313-26. 2010
    ..AS) and azole-resistant (AR) clinical isolates of Candida albicans, we recently demonstrated that CDR1 overexpression in AR isolates is due to its enhanced transcriptional activation and mRNA stability...
  9. pmc A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans
    Alix Coste
    Institute of Microbiology, University Hospital Lausanne, Switzerland
    Genetics 172:2139-56. 2006
    ..situated near the mating-type locus on chromosome 5, is necessary for the upregulation of the ABC-transporter genes CDR1 and CDR2, which mediate azole resistance...
  10. ncbi Evolution of blood pressure in patients with Alzheimer's disease: a one year survey of a French Cohort (REAL.FR)
    O Hanon
    Department of Geriatrics, Hopital Broca, 75013 Paris, France
    J Nutr Health Aging 9:106-11. 2005
    ..To determine the evolution of blood pressure in patients with moderate Alzheimer's disease among a one year longitudinal survey and to evaluate the relationship between blood pressure and cognitive functions...
  11. ncbi Diagnostic strategy using a modified clinical decision rule and D-dimer test to rule out pulmonary embolism in elderly in- and outpatients
    Maaike Sohne
    Academic Medical Center, Department of Vascular Medicine, Room F4 136, Meibergdreef 9, 1105 AZ Amsterdam
    Thromb Haemost 94:206-10. 2005
    ..The safety and efficacy of the combination of a clinical probability (CDR) and d-dimer test in excluding pulmonary embolism in this group is unclear...
  12. doi Cognitive changes after parathyroidectomy in patients with secondary hyperparathyroidism
    Fong Fu Chou
    Department of Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien, Taiwan
    Surgery 143:526-32. 2008
    ..Cognitive impairment was frequently reported in uremic patients with dialysis, but improvements of cognition after parathyroidectomy for symptomatic secondary hyperparathyroidism have never been reported before...
  13. doi Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine
    Maryse Lemaire
    Departement de Pharmacologie, Universite de Montreal, QC, Canada
    Cancer Chemother Pharmacol 63:411-6. 2009
    ..deaminase with respect to the antineoplastic action of inhibitors of DNA methylation, 5-aza-2'-deoxycytidine (5-AZA-CdR) and zebularine. Zebularine has a dual mechanism of action, since it can also inhibit CR deaminase...
  14. pmc Orbital fracture clinical decision rule development: burden of disease and use of a mandatory electronic survey instrument
    Kabir Yadav
    Department of Emergency Medicine, The George Washington University, Washington, DC, USA
    Acad Emerg Med 18:313-6. 2011
    In preparation for development of a clinical decision rule (CDR) to promote more efficient use of computed tomography (CT) for diagnosing orbital fractures, the authors sought to estimate the annual incidence of orbital fractures in ..
  15. ncbi Combination of a thiazide, a vasodilator and reserpine compared with methyldopa plus hydrochlorothiazide in the treatment of hypertension in Zimbabwe
    C M Stein
    Department of Clinical Pharmacology, University of Zimbabwe, Harare
    S Afr Med J 77:243-5. 1990
    ..5 mg) and reserpine (0.1 mg) (CDR) was compared with methyldopa (MD) plus hydrochlorothiazide (HCT) for antihypertensive effect, adverse reactions, ..
  16. ncbi 2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia
    M Koshy
    University of Illinois at Chicago, Chicago, IL, USA
    Blood 96:2379-84. 2000
    ..For patients with no HbF elevation after HU treatment, augmentation of HbF levels by 5-aza-2'-deoxycytidine (5-aza-CdR, decitabine) could serve as an alternate mode of treatment...
  17. ncbi Non-neurological factors are implicated in impairments in gait and mobility among patients in a clinical dementia referral population
    Vince Salazar Thomas
    Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
    Int J Geriatr Psychiatry 17:128-33. 2002
    ..Gait disorders were very prevalent at each level of cognitive function [58.7% for CDR=0, 68.0% for CDR=0.5, 57.9% for CDR=1, 68.1% for CDR=2 and 76.9% for CDR=3, p=0...
  18. ncbi Urban and rural differences in mortality and causes of death in historical Poland
    Alicja Budnik
    Department of Anthropology, Adam Mickiewicz University, 61 614 Poznan, Poland
    Am J Phys Anthropol 129:294-304. 2006
    ..Mortality measures such as crude death rate (CDR), infant death rate (IDR), and neonatal and postneonatal death rates were calculated...
  19. ncbi The increased flexibility of CDR loops generated in antibodies by Congo red complexation favors antigen binding
    Marcin Krol
    Dept of Bioinformatics and Telemedicine, Medical College, Jagiellonian University, Kopernika 17, 31 501 Krakow, Poland
    J Biomol Struct Dyn 23:407-16. 2006
    ..The higher fluctuation of CDR-bearing loops enhances antigen binding, and allows even low-affinity antibodies to be engaged in immune complexes...
  20. ncbi Interaction of lysozyme with synthetic anti-lysozyme D1.3 antibody fragments studied by affinity chromatography and surface plasmon resonance
    E Lasonder
    Laboratory of Medical Microbiology, University of Groningen, Netherlands
    J Chromatogr A 676:91-8. 1994
    ..3 show interaction with lysozyme. Surface plasmon resonance with immobilized CDR peptides showed that this interaction is not based on the antigen-antibody interaction...
  21. ncbi Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase
    C J Winters
    Department of Medicine, Medical College of Virginia, Richmond 23298
    Biochemistry 29:1080-7. 1990
    ..This reaction is controlled by a cytosolic enzyme, chlordecone reductase (CDR), which may be of the aldo-keto reductase family of xenobiotic metabolizing enzymes [Molowa et al. (1986) J. Biol...
  22. ncbi [A longitudinal study of the course of Alzheimer type dementia]
    J A Tellería-Díaz
    Hospital Clinico Quirurgico Hermanos Ameijeiras, La Habana, Cuba
    Rev Neurol 25:1551-6. 1997
    ..We carried out a prospective longitudinal study of 41 patients diagnosed as probably having a mild form of Alzheimer's disease according to the data of an investigation of prevalence done in 1991 in the municipality of Habana Vieja...
  23. pmc Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates
    Alix Coste
    Institute of Microbiology, University of Lausanne and University Hospital Center, Rue du Bugnon 48, CH 1011, Lausanne, Switzerland
    Eukaryot Cell 6:1889-904. 2007
    TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation of the ABC transporters CDR1 and CDR2, which mediate azole resistance in Candida albicans...
  24. pmc Genome-wide expression and location analyses of the Candida albicans Tac1p regulon
    Teresa T Liu
    Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Eukaryot Cell 6:2122-38. 2007
    ..To identify the Tac1p regulon, we analyzed four matched sets of clinical isolates representing the development of CDR1- and CDR2-mediated azole resistance by using gene expression profiling...
  25. doi Analysis of paediatric drowning deaths in Washington State using the child death review (CDR) for surveillance: what CDR does and does not tell us about lethal drowning injury
    Linda Quan
    University of Washington School of Medicine, Seattle, USA
    Inj Prev 17:i28-33. 2011
    Drowning is second cause of paediatric injury death in Washington State. Child death review (CDR) data provide the unique opportunity to identify regional risk factors and opportunities for drowning prevention.
  26. doi Using effectiveness and cost-effectiveness to make drug coverage decisions: a comparison of Britain, Australia, and Canada
    Fiona M Clement
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 302:1437-43. 2009
    ..This study describes how that evidence has been used across 3 jurisdictions (Australia, Canada, and Britain) that have been at the forefront of evidence-based coverage internationally...
  27. ncbi [Effects and mechanisms of 5-aza-2'-deoxycytidine on endometrial cancer cell.]
    Yu Quan Zhang
    Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong 226000, China Email
    Zhonghua Fu Chan Ke Za Zhi 44:861-4. 2009
    To investigate the effects and mechanisms of 5-aza-2'-deoxycytidine (5-Aza-CdR) on endometrial cancer cell.
  28. ncbi Using the cost distribution report in estimating private sector payments: what adjustments should researchers make?
    Gary Nugent
    Nebraska Western Iowa Health Care System, Omaha, NE, USA
    Med Care 41:II80-90. 2003
    ..To reapportion Veterans Health Administration (VA) annual expenditures into benefit categories for comparison with estimated payments by private sector providers...
  29. ncbi Corpus callosum atrophy, white matter lesions, and frontal executive dysfunction in normal aging and Alzheimer's disease. A community-based study: the Tajiri Project
    Kenichi Meguro
    Division of Neuropsychology, Department of Disability Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int Psychogeriatr 15:9-25. 2003
    ..We investigated the relationship between CC atrophy, WMH, and hippocampal atrophy, together with frontal executive dysfunction in both normal aging and AD...
  30. ncbi Electronic laboratory reporting for the infectious diseases physician and clinical microbiologist
    Rebecca Wurtz
    Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Infect Dis 40:1638-43. 2005
    ..Electronic communicable disease reporting (CDR), given its legal mandate and clear public health importance, is a significant early step in the sifting and ..
  31. ncbi Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications
    Ester Fonsatti
    Division of Medical Oncology and Immunotherapy, Department of Oncology, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy
    Clin Cancer Res 13:3333-8. 2007
    To investigate the potential of the DNA hypomethylating agent 5-aza-2'-deoxycytidine (5-aza-CdR) to improve the effectiveness of immunotherapeutic approaches against melanocyte differentiation antigens.
  32. pmc New methods for estimating the tuberculosis case detection rate in high-HIV prevalence countries: the example of Kenya
    John Mansoer
    US Department of Health and Human Services, Centers for Disease Control and Prevention, Nairobi, Kenya
    Bull World Health Organ 87:186-92, 192A-192B. 2009
    To develop new methods for estimating the sputum smear-positive tuberculosis case detection rate (CDR) in a country where infection with HIV is prevalent.
  33. doi Determinants of deforestation in Nepal's Central Development Region
    Keshav Bhattarai
    Department of Geography, University of Central Missouri, Warrensburg, MO 64093, USA
    J Environ Manage 91:471-88. 2009
    The process of deforestation in the Central Development Region (CDR) of Nepal is diverse in space and time, with rapid deforestation still occurring in areas outside the national parks and wildlife reserves...
  34. doi 3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase
    Noel J M Raynal
    Service of Hematology and Oncology, Université de Montréal and Centre de Recherche, CHU Saint Justine, 3175 Ste Catherine Road, Montreal, Quebec, H3T 1C5 Canada
    Leuk Res 35:110-8. 2011
    ..methylation plays an important role in leukemogenesis of ALL, it can be targeted by 5-aza-2'-deoxycytidine (5-AZA-CdR), a potent inhibitor of DNA methylation. 5-AZA-CdR is a prodrug that is activated by deoxycytidine kinase (DCK)...
  35. pmc Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    T C White
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, and Seattle Biomedical Research Institute, 98109, USA
    Antimicrob Agents Chemother 41:1482-7. 1997
    ..levels of total RNA from these isolates, we observed increased mRNA levels of ERG16 (the 14DM-encoding gene), CDR1 (an ABC transporter), and MDR1 (a major facilitator) in this series...
  36. ncbi A novel monoclonal antibody design for radioimmunotherapy
    Andres Forero
    Department of Medicine, Division of Hematology Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Cancer Biother Radiopharm 18:751-9. 2003
    The generation of chimeric and complementary-determining region (CDR) grafted monoclonal antibodies (MAb) have reduced the immunogenicity problem in the clinical application of radioimmunotherapy with monoclonal antibodies...
  37. pmc Utility of the clinical dementia rating in Asian populations
    Wee Shiong Lim
    Department of Geriatric Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
    Clin Med Res 5:61-70. 2007
    ..The Clinical Dementia Rating (CDR) is an informant-based global assessment scale with established reliability and validity that has been widely ..
  38. doi Biochemical markers in persons with preclinical familial Alzheimer disease
    J M Ringman
    UCLA Department of Neurology, Alzheimer Disease Research Center, 10911 Weyburn Ave, Suite 200, Los Angeles, CA 90095 7226, USA
    Neurology 71:85-92. 2008
    ..Persons at risk for familial Alzheimer disease (FAD) provide a model in which biomarkers can be studied in presymptomatic disease...
  39. ncbi Medicine reimbursement recommendations in Canada, Australia, and Scotland
    Joel Lexchin
    School of Health Policy and Management, York University, 4700 Keele St, Toronto, Ontario, Canada M3J 1P3
    Am J Manag Care 14:581-8. 2008
    This study was undertaken to compare the recommendations made by the Canadian Common Drug Review (CDR) regarding whether drugs should be listed on provincial and federal formularies with recommendations made by similar bodies in other ..
  40. pmc Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region
    Gilad Ofek
    Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 84:2955-62. 2010
    ..Here, we mutationally alter a hydrophobic patch on the third complementarity-determining region of the heavy chain (CDR H3) of the 2F5 antibody and assess the abilities of altered 2F5 variants to bind gp41 and to neutralize diverse ..
  41. ncbi Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations
    Vlastimil Král
    Department of Recombinant Expression and Structural Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 166 37 Prague, Czech Republic
    Proteins 71:1275-87. 2008
    ..of the crystal structures of free Fab M75 and its complex with the epitope peptide reveal major readjustments of CDR-H1 and CDR-H3...
  42. doi Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve
    Anthony F Fotenos
    Division of Biology and Biomedical Sciences, Washington University Medical School, St Louis, Missouri, USA
    Arch Neurol 65:113-20. 2008
    ..To assess the relation between socioeconomic status (SES) and structural brain change in nondemented older adults and to ascertain the potential role of preclinical Alzheimer disease (AD)...
  43. ncbi Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity
    Xu Feng Huang
    Department of Biomedical Science, Molecular Neurobiology Laboratory, University of Wollongong, NSW2522, Australia
    Brain Res Mol Brain Res 135:150-61. 2005
    ..and tyrosine hydroxylase (TH) mRNA expression in chronic high-fat diet-induced obese (cDIO) and obese-resistant (cDR) mice...
  44. ncbi Behavioral and psychological symptoms of dementia characteristic of mild Alzheimer patients
    Jin Shimabukuro
    Department of Psychiatry, Tohoku University Hospital, Sendai, Japan
    Psychiatry Clin Neurosci 59:274-9. 2005
    ..BPSD) in patients with mild Alzheimer's disease (AD), BPSD among the severities of Clinical Dementia Rating (CDR) in 74 patients with AD were compared using the Neuropsychiatric inventory (NPI)...
  45. ncbi Increased expression and hotspot mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from vaginitis patients
    Chung Yeng Looi
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    FEMS Microbiol Lett 249:283-9. 2005
    The aims of our research were to investigate the gene expression of the multidrug efflux transporter, CDR1 and the major drug facilitator superfamily transporter, MDR1 gene in azole drug-resistant Candida albicans and Candida glabrata ..
  46. ncbi An audit of intra-oral digital radiographs for endodontics
    R Austin
    Department of Primary Dental Care, King s College London Dental Institute, London, UK
    Int Endod J 43:351. 2010
    ..There were three phases. The first phase compared the Schick CDR system with Digora Optime...
  47. pmc Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo
    Bushra Ateeq
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Neoplasia 10:266-78. 2008
    The mechanism of action of DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-aza-CdR), a potential anticancer agent is believed to be activated by the demethylation of tumor suppressor genes...
  48. ncbi Evaluation of a data warehouse in an academic health sciences center
    J R Schubart
    Department of Health Evaluation Sciences, University of Virginia School of Medicine, P O Box 800717, Charlottesville, VA 22908 0717, USA
    Int J Med Inform 60:319-33. 2000
    The Clinical data repository (CDR) at the University of Virginia Health System is a data warehouse that provides direct access to data for clinical research and effective decision making...
  49. ncbi Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies
    John Paul Vermitsky
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA
    Mol Microbiol 61:704-22. 2006
    ..the predominant mechanism behind azole resistance is upregulated expression of multidrug transporter genes CDR1 and PDH1...
  50. ncbi The clinical dementia rating sum of box score in mild dementia
    C A Lynch
    Mercer s Institute for Research on Ageing, St James s Hospital, Dublin, Ireland
    Dement Geriatr Cogn Disord 21:40-3. 2006
    ..The Clinical Dementia Rating (CDR) scale is a widely used dementia staging instrument, yielding a global score and a summated score (sum of box score)..
  51. ncbi [Effect of a methylation inhibitor 5-aza-2'-deoxycytidine on SHP-1 gene expression, proliferation and apoptosis in K562 cells]
    Jian Min Luo
    Department of Hematology, Hebei Medical University Shijiazhuang 050000, Hebei Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:309-14. 2009
    The aim of this study was to investigate the regulation of 5-aza-CdR on transcription of SHP-1 gene and effects on the proliferation and apoptosis of K562 cells...
  52. ncbi Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene
    D Sanglard
    Institut de Microbiologie Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Microbiology 143:405-16. 1997
    ..When the disruption of CDR2 was performed in the background of a mutant in which CDR1 was deleted, the resulting double delta cdr1 delta cdr2 mutant was more susceptible to these agents than the single ..
  53. ncbi Mechanism for the decrease in the accumulation of cadmium (Cd) in Cd-resistant Chinese hamster V79 cells
    N Tsuchiya
    Department of Environmental Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan
    Arch Toxicol 68:325-31. 1994
    The mechanism for the decrease in the accumulation of cadmium (Cd) in Cd-resistant Chinese hamster V79 (Cdr) cells in culture was investigated in a comparison with Cd-sensitive (Cds) cells...
  54. ncbi An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment
    Haiying Wang
    Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xueyuan Road, Beijing, China
    J Biol Chem 283:2564-74. 2008
    ..was investigated in the human cancer cell lines A549 and HCT116 in response to 5-aza-2'-deoxycytidine (5-aza-CdR) or cytarabine treatment...
  55. ncbi [Effect of (-)-epigallocatechin-3-gallate and 5-AZA-CdR on expression of X-linked inhibitor of apoptosis protein-associated factor 1 in human leukemia HL-60 and K562 cells]
    Yun yan Huang
    Department of Pediatrics, College of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:204-8. 2008
    ..factor 1 (Xaf1) in human leukemia HL-60 and K562 cells treated with interferon alpha (INFalpha) and the demethylating agent 5-AZA-CdR, and observe the synergetic antitumor effect of Xaf1 inducer and (-)-epigallocatechin-3-gallate (EGCG).
  56. doi An initial assessment of the consumer demand roundtable: Results and promise
    Dianne C Barker
    Barker Bi Coastal Health Consultants, Inc, Calabasas, California 91302, USA
    Am J Prev Med 38:S437-46. 2010
    An initial assessment of the National Tobacco Cessation Collaborative's (NTCC) 2005-2007 Consumer Demand Roundtable (CDR) was conducted in 2008 to assess the results and products of CDR, and to offer recommendations to guide ongoing NTCC ..
  57. ncbi Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
    E Masliah
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Neurology 56:127-9. 2001
    ..and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0...
  58. ncbi Maintenance of B lymphocyte-related clones in the cerebrospinal fluid of multiple sclerosis patients
    Monica Colombo
    U O Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 33:3433-8. 2003
    ..e. had the same third complementary determining region (CDR) of the H chain variable region gene (HCDR3) with different mutations in the V(H) segment...
  59. ncbi Neuropsychological and functional measures of severity in Alzheimer disease, frontotemporal dementia, and semantic dementia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, San Francisco, California 94143 1207, USA
    Alzheimer Dis Assoc Disord 18:202-7. 2004
    ..We examined a functional measure of severity (Clinical Dementia Rating scale [CDR] scores) in patients with Alzheimer disease (AD, n = 23), frontotemporal dementia (FTD, n = 24), and semantic ..
  60. pmc The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin
    Ian Giles
    Centre for Rheumatology, Department of Medicine, University College London, UK
    Arthritis Res Ther 7:R47-56. 2005
    ..In CDR exchange studies, VL containing B3VL CDR1 were associated with elevated CL binding, which was reduced significantly by substitution of a CDR1 arginine ..
  61. ncbi An update on antifungal targets and mechanisms of resistance in Candida albicans
    Robert A Akins
    Wayne State University School of Medicine, Departments of Biochemistry and Molecular Biology, 540 East Canfield, Detroit, Michigan 48201, USA
    Med Mycol 43:285-318. 2005
    ..Attention has focused on five major C. albicans genes: ABC transporter genes CDR1 and CDR2, major facilitator efflux gene MDR1, and ergosterol biosynthesis genes ERG11 and ERG3...
  62. ncbi Value of partogram in vaginal birth after caesarean section
    A Omole-Ohonsi
    Department of Obstetrics and Gynaecology, Aminu Kano Teaching Hospital, PMB 3452, Kano, Nigeria
    J Obstet Gynaecol 27:264-6. 2007
    ..The outcomes measured were the duration of labour, cervical dilatation rate (CDR), and average cervical dilatation rate (ACDR). The data obtained were analysed using Z-test and tests of validity...
  63. ncbi Incidence of dementia and associated risk factors in Japan: The Osaki-Tajiri Project
    Kenichi Meguro
    Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Japan
    J Neurol Sci 260:175-82. 2007
    ..The final participants included 204 (65.2%) healthy older adults (Clinical Dementia Rating, CDR 0) and 335 (73.1%) people with questionable dementia (CDR 0.5)...
  64. doi Structural basis for the function of anti-idiotypic antibody in immune memory
    J Vani
    Department of Microbiology and Cell Biology, Indian Institute of Science, C V Raman Avenue, Bangalore 560 012, Karnataka, India
    Mol Immunol 46:1250-5. 2009
    ..Our results show that a large portion of heavy chain containing the CDR regions of Ab(2) resembles the domain of the hemagglutinin housing the epitope regions...
  65. pmc Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire
    Jacob Glanville
    Research Informatics, Rinat Pfizer Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 106:20216-21. 2009
    ..of Kabat column-labeled profile Hidden Markov Models, and translated complementarity determining region (CDR) capture-recapture analysis. Pyrosequencing of domain amplicon and RCA PCR products generated 1...
  66. ncbi A novel route for the synthesis of mesoporous and low-thermal stability materials by coupled dissolution-reprecipitation reactions: mimicking hydrothermal mineral formation
    Joel Brugger
    Department of Mineralogy South Australian Museum North Terrace, Adelaide SA 5000, Australia
    Chimia (Aarau) 64:693-8. 2010
    ..of the metal ions through the mineral, many actually proceed via a coupled dissolution and reprecipitation (CDR) mechanism...
  67. pmc Global clinical dementia rating of 0.5 in MCI masks variability related to level of function
    Y L Chang
    Department of Psychology, National Taiwan University, Taipei, 10617 Taiwan
    Neurology 76:652-9. 2011
    To evaluate whether ratings on Clinical Dementia Rating (CDR) items related to instrumental activities of daily living (IADL) are associated with cognitive or brain morphometric characteristics of participants with mild cognitive ..
  68. doi Gene silencing of EREG mediated by DNA methylation and histone modification in human gastric cancers
    Jiyeon Yun
    Cancer Research Institute, Seoul National University College of Medicine, South Korea
    Lab Invest 92:1033-44. 2012
    ..Treatment with 5-aza-CdR restored EREG expression and demethylated CpG sites in the EREG promoter...
  69. pmc Heterogeneous epigenetic regulation of TIMP3 in prostate cancer
    Toshiaki Shinojima
    Department of Molecular Oncology, John Wayne Cancer Institute at St John s Health Center, Santa Monica, CA, USA
    Epigenetics 7:1279-89. 2012
    ..Treatment of DU145 cells with 5-aza-2'-deoxycytidine (5-Aza-CdR) restored TIMP3 expression, and this was significantly amplified by co-treating the cells with the HDAC inhibitor ..
  70. pmc Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41
    Jia Chen
    Division of Molecular Medicine, Boston Children s Hospital, Boston, Massachusetts, USA
    J Virol 88:1249-58. 2014
    ..show by three independent approaches that 10E8 indeed binds lipid bilayers through two hydrophobic residues in its CDR H3 (third heavy-chain complementarity-determining region)...
  71. pmc Community HIV-1 drug resistance is associated with transmitted drug resistance
    M W Tilghman
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    HIV Med 15:339-46. 2014
    ..load (CVL) measurements are associated with the incidence of new HIV-1 infections in a population, we hypothesized that similarly measured community drug resistance (CDR) could predict the prevalence of transmitted drug resistance (TDR).
  72. pmc A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity
    Xuelian Bai
    Department of Life Science, Ewha Womans University, Seoul, Korea
    PLoS ONE 10:e0141045. 2015
    ..validation of a human scFv library with a novel design approach to synthetic complementarity determining region (CDR) diversification...
  73. doi Stacked ensemble combined with fuzzy matching for biomedical named entity recognition of diseases
    Balu Bhasuran
    DRDO BU Center for Life Sciences, Bharathiar University Campus, Coimbatore 641046, India
    J Biomed Inform 64:1-9. 2016
    ..Our proposed approach shows promised result of 94.66%, 89.12%, 84.10%, and 76.71% of F-measure while on evaluating training and testing set of both NCBI disease and BioCreative V CDR Corpora.
  74. pmc Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM
    J Bajorath
    Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121, USA
    Protein Sci 4:1644-7. 1995
    ..We report the construction, assessment, and analysis of a molecular model of ALCAMD1. The model defines the CDR-analogous loops, the location of N-linked glycosylation sites, and residues that form the beta-sheet faces of the ..
  75. ncbi Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling
    T Olafsen
    Division of Molecular and Cell Biology, University of Oslo, Norway
    Nucl Med Biol 22:765-71. 1995
    ..The V-domains of TP-1 contain a total of 12 lysines, 10 in the framework region and 2 in the CDR region, while the V-domains of TP-3 contain a total of 14 lysines, 11 in the framework region and 3 in the CDR ..
  76. ncbi Importance of a conserved TCR J alpha-encoded tyrosine for T cell recognition of an HLA B27/peptide complex
    P Bowness
    Molecular Immunology Group, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, GB
    Eur J Immunol 28:2704-13. 1998
    ..Eur J. Immunol. 1993. 23: 1417-1421). The role of TCR complementarity-determining region (CDR)3alpha residues 93 and 100-102 was examined by site-directed mutagenesis, following expression of the TCR alpha and ..
  77. ncbi HLA (A*0201) mimicry by anti-idiotypic monoclonal antibodies
    W J Burlingham
    Department of Surgery, University of Wisconsin, Madison 53792, USA
    J Immunol 161:6705-14. 1998
    ..A2 and SN66E3 revealed short regions of homology with both human mAb; a large insert in the light chain CDR1 of mAb SN66E3 distinguished it from both CRll-351 and Ha5C2.A2...
  78. ncbi Users' guides to the medical literature: XXII: how to use articles about clinical decision rules. Evidence-Based Medicine Working Group
    T G McGinn
    Adult Primary Care, Mount Sinai Medical Center, One Gustave Levy Place, New York, NY 10029 6574, USA
    JAMA 284:79-84. 2000
    ..A clinical decision rule (CDR) is a clinical tool that quantifies the individual contributions that various components of the history, physical ..
  79. ncbi Adding value to clinical data by linkage to a public death registry
    R D Pates
    Department of Health Evaluation Sciences, University of Virginia Medical School, Charlottesville, Virginia 22908, USA
    Stud Health Technol Inform 84:1384-8. 2001
    ..of merging detailed statewide mortality data into the master patient index tables of the clinical data repository (CDR) of the University of Virginia Health System (UVAHS)...
  80. ncbi Crystal structure of the liganded anti-gibberellin A(4) antibody 4-B8(8)/E9 Fab fragment
    Takashi Murata
    Department of Applied Biological Chemistry, Division of Agriculture and Agricultural Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 293:489-96. 2002
    ..A small hapten-combining site was made up of three heavy chain CDR loops. On the other hand, CDRs of the light chain did not interact directly with GA(4)...
  81. ncbi The acute nootropic effects of Ginkgo biloba in healthy older human subjects: a preliminary investigation
    Pradeep J Nathan
    Neuropharmacology Laboratory, Brain Sciences Institute, Swinburne University of Technology, Australia
    Hum Psychopharmacol 17:45-9. 2002
    ..of Ginkgo biloba (120 mg) on memory functioning in healthy older volunteers using the cognitive drug research (CDR) battery of memory tests and the Rey auditory verbal learning task (AVLT)...
  82. ncbi The antibody repertoire in evolution: chance, selection, and continuity
    John J Marchalonis
    Department of Microbiology and Immunology, College of Medicine, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724 5049, USA
    Dev Comp Immunol 30:223-47. 2006
    ..structures of shark VH/VL combining sites indicate similarity in framework structure and comparable CDR usage to those of man...
  83. ncbi [Asymptomatic 32 year old female smoker with persistent polyclonal lymphocytosis]
    B Chapuy
    Abteilung für Hämatologie und Onkologie, Universitätsklinikum Göttingen, Gottingen, Deutschland
    Internist (Berl) 48:314-8. 2007
    ..IgH-CDR-3 PCR analysis revealed a polyclonal pattern...
  84. ncbi [Diabetic ketoacidosis in Denmark--registry-based estimation of incidence and mortality. Secondary publication]
    Otto Mølby Henriksen
    Bispebjerg Hospital, Medicinsk Klinik I, Endokrinologisk Sektion, Klinisk Fysiologisk Nuklearmedicinsk Afdeling
    Ugeskr Laeger 169:2335-7. 2007
    ..with a diagnosis of DKA from the Danish National Patient Registry (NPR) and the Danish Cause of Death Registry (CDR) respectively. The annual incidence of DKA in the general population was estimated to 12.9 per 100,000...
  85. ncbi A study in glycation of a therapeutic recombinant humanized monoclonal antibody: where it is, how it got there, and how it affects charge-based behavior
    Cynthia Quan
    Analytical Development, Genentech, South San Francisco, CA 94080, USA
    Anal Biochem 373:179-91. 2008
    ..Low-level glycation on a heavy chain lysine located within a complementarity-determining region (CDR) did not significantly affect binding activity in potency measurements...
  86. doi How long can patients with mild or moderate Alzheimer's dementia maintain both the cognition and the therapy of cholinesterase inhibitors: a national population-based study
    Y Sun
    Department of Neurology, En Chu Kong Hospital, Taipei, Taiwan
    Eur J Neurol 15:278-83. 2008
    ..BNHI, if the score of Mini-Mental Status Examination worsened by more than two points or clinical dementia rating (CDR) worsened by one or more grades in the follow-up every half year, the AChEI treatment would be terminated...
  87. doi Overexpression of rice (Oryza sativa L.) OsCDR1 leads to constitutive activation of defense responses in rice and Arabidopsis
    Bishun Deo Prasad
    Genome Research Centre, Department of Microbiology and Biotechnology Centre, Faculty of Science, The M S University of Baroda, Vadodara, Gujarat, India
    Mol Plant Microbe Interact 22:1635-44. 2009
    ..These results demonstrate the conservation of CDR1 function between rice and Arabidopsis during the disease resistance response.
  88. pmc High affinity anti-inorganic material antibody generation by integrating graft and evolution technologies: potential of antibodies as biointerface molecules
    Takamitsu Hattori
    Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai 980 8579, Japan
    J Biol Chem 285:7784-93. 2010
    ..peptide sequence was first grafted into an appropriate loop of the complementarity determining region (CDR) of a camel-type single variable antibody fragment to create a low affinity material-binding antibody...
  89. doi Humanization strategies for an anti-idiotypic antibody mimicking HIV-1 gp41
    A Mader
    Department of Biotechnology, Institute for Applied Microbiology, BOKU University of Natural Resources and Applied Life Sciences, Muthgasse 11, A 1190 Vienna, Austria
    Protein Eng Des Sel 23:947-54. 2010
    ..were subjected to three different humanization approaches, namely resurfacing, complementarity determining region (CDR)-grafting and superhumanization...
  90. doi Effects of DNMT and MEK inhibitors on the expression of RECK, MMP-9, -2, uPA and VEGF in response to arsenite stimulation in human uroepithelial cells
    Ya Chun Huang
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Toxicol Lett 201:62-71. 2011
    ..However, when the cells were pretreated with inhibitors (5-aza-CdR or U0126) for 24h, the effects of arsenite on RECK, MMP-9, -2, uPA and VEGF expression were suppressed...
  91. pmc Mild cognitive impairment: prodromal Alzheimer's disease or something else?
    William G Britt
    Department of Psychiatry, Loma Linda University, Redlands, CA, USA
    J Alzheimers Dis 27:543-51. 2011
    ..The data includes serial informant-based measures (Clinical Dementia Rating [CDR]) and a comprehensive battery of neuropsychological tests analyzed by two different regression methods...
  92. doi Structure of Fab fragment of malaria transmission blocking antibody 2A8 against P. vivax P25 protein
    Ajay K Saxena
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Int J Biol Macromol 50:153-6. 2012
    ..of native Fab2A8 structure with antigen bound Fab2A8 structure indicates the significant conformational changes in CDR-H1 and CDR-H3 regions of V(H) domain and CDR-L3 region of V(L) domain of Fab2A8...
  93. pmc Vβ2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen
    Onisha Patel
    Protein Crystallography Unit, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    Proc Natl Acad Sci U S A 108:19007-12. 2011
    ..within the Vβ2 NKT TCR-CD1d-αGalCer complex, the CDR2β loop mediated fewer contacts with CD1d, whereas the CDR1β and CDR3β loops contacted CD1d to a much greater extent compared with most Vβ11, Vβ8.2, and Vβ7 NKT TCRs...
  94. pmc Product development studies on surface-adsorbed nanoemulsion of olmesartan medoxomil as a capsular dosage form
    Sumita Singh
    Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, 281001, Uttar Pradesh, India
    AAPS PharmSciTech 13:1212-21. 2012
    ..75% v/v), and double-distilled water (75% v/v) displayed highest percentage cumulative drug release (%CDR; 96.69 ± 1.841), least globule size (17.51 ± 5.87 nm), low PDI (0.203 ± 0...
  95. pmc T-cell receptors binding orientation over peptide/MHC class I is driven by long-range interactions
    Mathias Ferber
    Multidisciplinary Oncology Center, Lausanne University Hospital CHUV, Lausanne, Switzerland
    PLoS ONE 7:e51943. 2012
    ..Results show that most of the driving force leading to the formation of the complex is defined by CDR1,2/MHC interactions...
  96. pmc Improved dose-volume histogram estimates for radiopharmaceutical therapy by optimizing quantitative SPECT reconstruction parameters
    Lishui Cheng
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Phys Med Biol 58:3631-47. 2013
    ..images were reconstructed using QSPECT with compensation for attenuation, scatter and collimator-detector response (CDR). Dose rate distributions were estimated by convolution of the activity image with a voxel S kernel...
  97. pmc Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma
    Julio Finalet Ferreiro
    Center for Human Genetics, KU Leuven, Leuven, Belgium
    PLoS ONE 9:e102977. 2014
    ..Using high resolution array CGH, we profiled all cases and mapped the common deleted region (CDR) at 7p22.1p14.1 (34.88 Mb; 3506316-38406226 bp) and the common gained region (CGR) at 7q22.11q31.1 (38...
  98. pmc Structural basis for the recognition in an idiotype-anti-idiotype antibody complex related to celiac disease
    Anna Vangone
    Department of Chemistry and Biology, University of Salerno, Fisciano, Salerno, Italy
    PLoS ONE 9:e102839. 2014
    ..In the obtained model, AIM2 is directed against the MB2.8 CDR region, especially on its variable light chain. This makes the concurrent formation of the MB2...
  99. doi MiR-335 inhibits migration of breast cancer cells through targeting oncoprotein c-Met
    Yue Gao
    Molecular Medicine and Cancer Research Center, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China
    Tumour Biol 36:2875-83. 2015
    ..MiR-335 expression was increased after 5-aza-2'-deoxycytidine (5-AZA-CdR) treatment, and 5-AZA-CdR treatment resulted in the same phenotype as the effect of miR-335 overexpression...
  100. pmc Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network
    John M Ringman
    1 Mary S Easton Centre for Alzheimer s Disease Research at UCLA, 10911 Weyburn Ave, 200, Los Angeles, CA, 90095, USA
    Brain 138:1036-45. 2015
    ..Inventory-Questionnaire, the 15-item Geriatric Depression Scale and the Clinical Dementia Rating Scale (CDR). Ninety-seven asymptomatic (CDR = 0), 25 mildly symptomatic (CDR = 0.5), and 33 overtly affected (CDR > 0...
  101. ncbi Multimedia Health Records: user-centered design approach for a multimedia uploading service
    Fernando Plazzotta
    Departamento de Informática en Salud, Hospital Italiano de Buenos Aires, Argentina
    Stud Health Technol Inform 210:474-8. 2015
    ..processes of a service which allows media elements to be loaded in a patient clinical data repository (CDR) either through an electronic health record by professionals (EHR) or through a personal health record (PHR) by ..

Research Grants67

  1. Andrew D Weinberg; Fiscal Year: 2014
    ..humanization of the anti-OX40 antibody after insertion of the identical murine antibody's variable region CDR sequences into human IgG frameworks, assessment of OX40 binding and bioactivity in vitro, and development of a ..
  2. A novel pre-defined CDR library for selection of affinity reagents
    Michael P Weiner; Fiscal Year: 2013
    ..We have termed this new library-type as a 'pre-defined CDR'(PDC) library...
  3. Development of a Novel Method for Inhibiting Atherosclerosis in Diabetes
    David R Clemmons; Fiscal Year: 2010
    ..structure of the antibody will be undertaken to determine those residues that are within 10 angstroms of the CDR antigen binding site. These residues will also be modified to reduce their interaction with the binding domain...
  4. Mucosal Immune Ontogeny and Intestinal Microbiota in Infants
    Edward N Janoff; Fiscal Year: 2010
    ..In B cells, immunoglobulin genes, particularly the 3 hypervariable complementarity determining regions (CDR) of heavy chains (VH), show the greatest diversity and contribute most to antigen binding5...
  5. Role of IG CDR-H3 in Responses to HIV Vaccines
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2013
    ..the norm in that each of their antigen binding sites contain a long, H chain complementarity determining region 3 (CDR-H3) that lacks tyrosine and includes patches of hydrophobic and charged amino acids...
  6. Mark J Young; Fiscal Year: 2014
    ..2) Antibody CDR dimers (Specific aim 2)...
  7. Jason T Kimata; Fiscal Year: 2015
    ..data indicate that targeting single-chain Fv (scFv) or the heavy chain third complementarity-determining region (CDR H3) of some anti-HIV-1 Env MAbs to lipid rafts with a glycosyl-phosphatidyl-inositol (GPI)-anchor enhances their ..
  8. Immunoglobulin CDR-H3 and neutralizing antibodies to HIV
    Harry Schroeder; Fiscal Year: 2009
    ..that each of their antigen binding sites contain a long, hydrophobic H chain complementarity determining region 3 (CDR-H3)...
  9. PROTEOLYTIC ANTIBODIES FOR TREATMENT OF PSORIASIS
    ROBERT BALINT; Fiscal Year: 2009
    ..repertoire contain canonical serine protease-like catalytic triads in their complementarity-determining regions (CDR), and some have detectable peptidolytic activity...
  10. The role of T cell repertoire selection in the NOD mouse model of MOG-induced EAE
    Anthony Quinn; Fiscal Year: 2007
    ..Since CDR1 and CDR2 of the TCR V beta 8 chain are encoded by BV8, our findings suggests that the MOG reactive T cell ..
  11. Cocaine degradation: Improving antibody efficacy
    KATHLEEN MCKENZIE; Fiscal Year: 2006
    ..The first involves affinity maturation by complementarity determining region (CDR) walking based on unpublished crystal structure results from the Wilson and Janda laboratories, while the second ..
  12. ENGINEERING OF ANTIDIGOXIN ANTIBODY COMBINING SITES
    MICHAEL MARGOLIES; Fiscal Year: 1999
    ..of mutagenesis, employing, as appropriate, random mutagenesis of entire V regions, site-directed mutagenesis, CDR loop lengthening, and combinatorial mutagenesis involving different CDRs and both chains...
  13. ANTIBODY DISPLAY OF PEPTIDE ANTAGONISTS OF IL-1 RECEPTOR
    Jeffry Watkins; Fiscal Year: 1999
    ..Display of the peptides within the third complementarity-determining region (CDR) of the heavy chain will be optimized by synthesis of expression libraries in which the CDR positions of the ..
  14. Molecular Principles of TCR Recognition and Activation by Peptide MHC
    KENAN CHRISTOPHER GARCIA; Fiscal Year: 2011
    ..MHC may be attributable to specific, germline-encoded recognition rules between residues on the TCR Variable region CDR1 and 2 loops, and residues on the MHC helices...
  15. Conformationally-Constrained PA Anthrax Vaccine
    Maurizio Zanetti; Fiscal Year: 2005
    ..crystallography studies characterized this loop as having the structure of the complementarity-determining region (CDR) of an immunoglobulin (Ig)...
  16. Mark I Greene; Fiscal Year: 2015
    ..We will use a fragment of human HER2 that is structurally like a CDR and link it to human Fc fragments...
  17. Longitudinal study of membrane lipids: pre-clinical Alzheimer's biomarkers
    Michelle M Mielke; Fiscal Year: 2010
    ..and our preliminary data, suggest these lipids are altered in blood, CSF and brain in the earliest stages of AD (CDR 0.5), and vary by AD severity...
  18. Suzanne Craft; Fiscal Year: 2016
    ..Two-hundred and forty participants with aMCI (Petersen criteria, Clinical Dementia Rating/CDR 0.5) or mild AD (NINDS-ADRDA criteria, CDR 0.5-1.0, Mini-mental State Exam20) will be enrolled...
  19. GROVER CLEVELAND GILMORE; Fiscal Year: 2015
    ..Patients will be stratified by AD severity (CDR mild or moderate) and cataract severity (LOCS 1-2 or 3-4) prior to being randomized...
  20. Yvette I Sheline; Fiscal Year: 2015
    ..placebo controlled trial of 54 cognitively normal participants, age 65- 80, (Clinical Dementia Rating scale, [CDR] = 0) recruited from the Washington University ADRC...
  21. Conversational Engagement as a Means to Delay Alzheimer's Disease Onset
    HIROKO HAYAMA DODGE; Fiscal Year: 2012
    ..Aim 2. Among those interviewed in Aim 1, we will recruit 80 subjects with Clinical Dementia Rating Scale (CDR) = 0 and 80 subjects with CDR = 0.5 from the lower end of the social engagement frequencies...
  22. Functional Decline in Three Dementia Types
    WALTER ANTHONY KUKULL; Fiscal Year: 2012
    ..of probable AD, probable VaD, or DLB);2) age 60+ years (visit 1);3) Clinical Dementia Rating-Sum of Boxes (CDR-SOB) score <16 (visit 1);and 4) time between successive visits restricted to 0.5-1.5 years...
  23. Age related Cognitive Loss in Mumbai, India
    Dushyant P Purohit; Fiscal Year: 2010
    ..who come to autopsy and are free of cognitive impairment (based on a postmortem Clinical Dementia Rating Score or CDR of 0)...
  24. Measuring change in Alzheimer's disease dysfunction more precisely with IRT
    Steve Balsis; Fiscal Year: 2012
    ..To do this we will extend our preliminary cross-sectional findings for this measure, the MMSE, and the CDR, to examine data longitudinally in Baylor College of Medicine's Alzheimer's Disease and Memory Disorder ..
  25. DELIRIUM IN PERSONS WITH DEMENTIA
    Donna Fick; Fiscal Year: 2007
    ..of Daily Living Scale (IADL), Charlson Co-morbidity Index, Apache II, the Clinical Dementia Rating scale (CDR), a family semi-structured interview form, and a Modified Blessed Scale...
  26. TARGETING THE B-CELL RECPTOR COMPLEX AND DOWNSTREATM KINASES
    Sydney Welt; Fiscal Year: 2010
    ..Previous strategies to target the BCRC molecules in B-cell malignancies have focused on the unique CDR sequences specific for each monoclonal tumor...
  27. AIDS Related Candidiasis: Dynamic Expression of Drug Resistant Genes
    Theodore C White; Fiscal Year: 2010
    ..four genes are known to be constitutively overexpressed include the target enzyme ERG11, and three efflux pumps, CDR1, CDR2, and MDR1. In susceptible Ca, these genes can be transcriptionally induced when exposed to drugs...
  28. Mechanisms of drug resistance in Candida albicans
    Brian Wong; Fiscal Year: 2007
    ..It also is not known if mutations in these pumps' structural genes (CDR1, CDR2 and MDR1) cause azole resistance in clinical C. albicans strains...
  29. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2012
    ..It is our hypothesis that failure to properly regulate one specific part of the antibody, CDR-H3, in susceptible individuals facilitates production of anti-DNA antibodies and triggers disease...
  30. ERIC M VERDIN; Fiscal Year: 2014
    ..We also found that the inhibitor of DNA methylation, 5-aza-2'deoxycytidine (aza-CdR), synergizes with NF-B activators to reactivate latent HIV...
  31. David A Scheinberg; Fiscal Year: 2016
    Over the last 15 years on this grant, we have established that biologically active, CDR grafted humanized IgG, novel radioconjugates and toxin conjugates, many based on the anti-CD33 Ig HuM195, can be constructed, characterized, and ..
  32. Anaerobic shock as a novel treatment for tuberculosis
    Xilin Zhao; Fiscal Year: 2010
    ..of multiple drug- resistant (MDR) infections and the emergence of extensively/completely drug-resistant (XDR/CDR) tubercle bacilli are making currently chemotherapies less and less effective...
  33. Kate Rittenhouse-Olson; Fiscal Year: 2014
    ..Humanization will precede using modified CDR grafting onto the human antibody molecule variable sequence found to be most like the JAA-F11 mouse sequence in ..
  34. MECHANISMS OF DE NOVO METHYLATION IN CANCER
    Peter A Jones; Fiscal Year: 2013
    ..This research has led to the recent approval by the FDA of two DNA demethylating agents (5-aza-CR and 5-aza-CdR) for the treatment of myeloid dysplastic syndrome...
  35. MOLECULAR ANALYSIS OF CD8, MHC CLASS I INTERACTION
    Paula B Kavathas; Fiscal Year: 2012
    ..We identified critical residues on the CDR-like loops of the immunoglobulin-like domain CD8b protein required for binding to pMHC1 as well as mutants that led ..
  36. Epigenetic alterations underlying tumorigenic potential of Glioblastoma Cells
    Theresa K Kelly; Fiscal Year: 2012
    ..with this information, in the independent phase, I will treat GBM cells with the DNA demethylating agent 5-Aza-CdR and measure the ability of demethylation to restore normal gene expression patterns and resolve aberrant chromatin ..
  37. Jeffrey J Gray; Fiscal Year: 2015
    ..work has isolated the most critical challenges: most of the antibodies in the human repertoire have hypervariable CDR H3 loops longer than that which is predictable using current loop methods;backbone conformational uncertainty and ..
  38. Rachel P Berger; Fiscal Year: 2014
    ..We have also derived a sensitive and specific clinical decision rule (CDR) for predicting ICN using easily measured clinical and laboratory variables...
  39. Molecular studies of lipid presentation and T cell recognition of CD1c
    ERIN JUNE ADAMS; Fiscal Year: 2013
    ..and/or cytotoxicity) and the sequence of their TCRs, specifically to determine whether there are motifs in the CDR loops that are used in this recognition process...
  40. AAC Rehabilitation for Conversation in Dementia
    Melanie Fried Oken; Fiscal Year: 2006
    ..Participants are 60 adults with moderate dementia as defined by a CDR score of 2, MMSE between 5-15, and enrollment in the Oregon Alzheimer's Disease Center...
  41. Characterization of Pathogenic T cells in Alopecia Areata
    EMANUAL M MAVERAKIS; Fiscal Year: 2012
    ..T cells can be identified, characterized and followed longitudinally in patients with alopecia areata by combining CDR-3 length repertoire analysis with magnetic sorting and flow cytometry...
  42. Daniel Starczynowski; Fiscal Year: 2016
    ..We recently identified miR-146a, which is near the distal CDR, to be significantly reduced in del(5q) MDS patients...
  43. BEHZAD MOSLEHI; Fiscal Year: 2015
    ..at the Stanford Medical School, Professor Mark Cutkosky's group at the Stanford Center for Design Research (CDR) and HeartVista, for clinical imaging platform software integration...
  44. Mary Clyde Pierce; Fiscal Year: 2015
    ..b>CDR modeling will be performed using a binary recursive partitioning algorithm...
  45. Janey L Wiggs; Fiscal Year: 2016
    ..primary focus of identifying genes contributing to the POAG-related quantitative endophenotype, cup-to-disc ratio (CDR)...
  46. Lei Liu; Fiscal Year: 2015
    ..methods will be applied to empirical case studies using three real-world databases: Clinical Data Repository (CDR) at the University of Virginia (UVA) Health System, Medical Expenditure Panel Survey (MEPS), and the SEER- Medicare ..
  47. HIV-1 Neutralizing Antibody Binding to Viral Membrane Mimics
    Stefan Zauscher; Fiscal Year: 2013
    ..2) CDR H3 loops on 2F5 and 4E10 embed selectively into mobile domains on HIV-1 Env mimetic membranes...
  48. Targeted Therapy of B-cell Malignancies
    David Goldenberg; Fiscal Year: 2009
    ..the most promising from our own published studies and those of others, and because we now have access to humanized (CDR-grafted) forms of these antibodies...
  49. Lawrence J Stern; Fiscal Year: 2016
    ..We will characterize interactions between TCR alpha subunit residues and beta subunit CDR loops, and vice versa, to determine how these shape MHC-TCR interaction...
  50. Storage and Distribution of Clinical Agents
    Young Kim; Fiscal Year: 2009
    ..requires an agent supply for an NCI study, the clinical trial site submits an order called a Clinical Drug Request (CDR)...
  51. JEFFREY MURRAY BURNS; Fiscal Year: 2016
    ..of Kansas Alzheimer's Disease Center (KU ADC;P30AG035982) will screen 400 sedentary, cognitively normal (CDR 0) individuals age 65 and older with Florbetapir PET imaging to enroll 100 preclinical AD participants into the ..
  52. Storage and Distribution of Clinical Agents
    Young Kim; Fiscal Year: 2010
    ..requires an agent supply for an NCI study, the clinical trial site submits an order called a Clinical Drug Request (CDR)...
  53. Brian M Baker; Fiscal Year: 2015
    ..bases for TCR specificity and cross-reactivity, focusing on three closely related topics: the dynamics of TCR CDR loops, the mechanisms by which TCRs engage pMHC, and the distribution of binding energy within TCR- pMHC interfaces...
  54. Storage and Distribution of Clinical Agents
    Young Kim; Fiscal Year: 2011
    ..requires an agent supply for an NCI study, the clinical trial site submits an order called a Clinical Drug Request (CDR)...
  55. PATHOGENESIS AND PREVENTION OF IDDM
    Hugh McDevitt; Fiscal Year: 2002
    ..These T cell receptor V beta and V alpha sequences have detectable shared CDR 3 sequence motifs, suggesting an antigen specific T cell response...
  56. PATHWAY FOR AUTOIMMUNE RECOGNITION BY GAMMA DELTA CELLS
    CRAIG MORITA; Fiscal Year: 1999
    ..Aim II, we will identify specific Vgamma2 TCR residues that mediate recognition of staphylococcal superantigens by CDR exchanges and site directed mutagenesis...
  57. ROLE OF THE GALLBLADDER IN PATHOGENESIS OF GALLSTONES
    LESTER WILLIAMS; Fiscal Year: 1991
    ..Since (1) GB stasis with increased cystic duct resistance (CDR) occurs early after initiating a lithogenic diet before crystals occur; (2) since increased GB prostaglandin (PG) ..
  58. Mechanisms of Cutaneous Drug Reactions
    CRAIG SVENSSON; Fiscal Year: 2004
    Cutaneous drug reactions (CDR) are among the most frequent adverse medical events. Recent studies suggest that between 30 and 45 percent of all adverse drug reactions involve the skin...
  59. Engineered antibody for reducing localized fibrotic scarring
    Andrzej Fertala; Fiscal Year: 2012
    ..will serve as a catalyst to develop their fully humanized versions through complementarily determining regions (CDR) grafting...
  60. CLONOTYPIC PCR FOR MINIMAL RESIDUAL DISEASE IN LYMPHOMA
    Ariela Noy; Fiscal Year: 2002
    ..The sequences of greatest diversity comprising complementarity region-III (CDR-III) or the V-beta counterpart provide excellent targets for clone specific MRD probes...
  61. NOD T CELL RECEPTORS FOR SPECIFIC ISLET AUTOANTIGENS
    Eric Simone; Fiscal Year: 2000
    ..Finally, young NOD mice will be immunized with either V(alpha)13.3a TCR peptides selected from the polymorphic CDR regions or V(alpha)13.3 DNA constructs, in an attempt to eliminate or immunomodulate endogenous V(alpha)13...
  62. COMBINED RADIOIMMUNOTHERAPY & CHEMOTHERAPY--COLON CANCER
    Malik Juweid; Fiscal Year: 1999
    ..We intend, therefore, to conduct a phase-I trial of combined 5-FU-LV and RAIT with a CDR-grafted (humanized) 131I-MN-14 (hMN-14) second-generation, high affinity anti-CEA MAb...
  63. Radioimmunotherapy: An Anti-Neoplastic Strategy
    Andres Forero; Fiscal Year: 2006
    ..3. The immunogenicity of mCC49, the long half-life (50h) and the projected even longer half-life of a chimeric or CDR-grafted version led to studies directed at humanization with deletion of various parts in search of a construct ..
  64. Developing a Rational Clinical Approach to the Disposition of TIA Cases in the ED
    Mathew Reeves; Fiscal Year: 2009
    ..The ABCD2 rule is a validated clinical decision rule (CDR) developed to risk stratify TIA cases in the ED. The rule stratifies TIA cases into 3 groups (i.e...
  65. Origin of Antibodies with Long CDR-H3 Loops in HIV Infection & Autoimmune Disease
    Jamie Scott; Fiscal Year: 2009
    ..A few broadly(b)-Nt Abs have been discovered: 4E10, 2F5, b12, 447-52D and 2G12;all but 2G12 have longer-than-usual CDR-H3 hypervariable loops (H3s)...
  66. RADIOIMMUNOTHERAPY OF ADVANCED REFRACTORY OVARIAN CANCER
    Malik Juweid; Fiscal Year: 1999
    ..proposal, we plan to conduct a phase I, dose escalating trial to determine the maximum tolerated dose (MTD) of the CDR-grafted (humanized) 131I-labeled MN-14 anti-CEA MAb in combination with peripheral blood stem cell rescue (PBSCR) ..
  67. SYNTHESIS OF ANTITUMOR/VIRAL PYRIMIDINE C-NUCLEOSIDES
    Kyoichi Watanabe; Fiscal Year: 1993
    ..c) Homo-oligomers of 2'-deoxy-pseudo-isocytidine (c-CdR), 2'-deoxy-9- deazaadenosine (c-AdR), 2'-deoxy-9-deazaguanosine (c-GdR) and 2'-deoxy- 9-deazainosine (c-IdR)...