CDH4

Summary

Gene Symbol: CDH4
Description: cadherin 4
Alias: CAD4, R-CAD, RCAD, cadherin-4, R-cadherin, cadherin 4, type 1, R-cadherin (retinal), cadherin 4, type 1, preproprotein, retinal cadherin
Species: human

Top Publications

  1. ncbi R-cadherin influences cell motility via Rho family GTPases
    Emhonta Johnson
    Department of Oral Biology, College of Dentistry, Eppley Institute for Research in Cancer and Allied Diseases, and Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 279:31041-9. 2004
  2. ncbi Co-ordinated expression of phycobiliprotein operons in the chromatically adapting cyanobacterium Calothrix PCC 7601: a role for RcaD and RcaG
    Sanaa Noubir
    Dynamique des Membranes Végétales, Complexes Protéines Pigments, CNRS UMR 8543, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Mol Microbiol 43:749-62. 2002
  3. ncbi Differential expression of cadherin-2 and cadherin-4 in the developing and adult zebrafish visual system
    Q Liu
    Department of Biology, University of Akron, Ohio 44325 3908, USA
    Vis Neurosci 18:923-33. 2001
  4. ncbi Targeting axons to specific fiber tracts in vivo by altering cadherin expression
    Ullrich Treubert-Zimmermann
    Institute of Anatomy, University of Essen Medical School, D 45122 Essen, Germany
    J Neurosci 22:7617-26. 2002
  5. ncbi Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafish
    Q Liu
    Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
    Exp Neurol 177:396-406. 2002
  6. pmc Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue
    S Suzuki
    Department of Ophthalmology, University of Southern California, School of Medicine, Los Angeles 90033
    Cell Regul 2:261-70. 1991
  7. ncbi Expression of cadherin-11 delineates boundaries, neuromeres, and nuclei in the developing mouse brain
    Y Kimura
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Dyn 206:455-62. 1996
  8. doi Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication-competent adenovirus or etoposide
    Xinjian Liu
    Experimental Center, First People s Hospital, Shanghai Jiaotong University, 85 Wu Jin Road, Shanghai, China
    Hum Gene Ther 21:157-70. 2010
  9. pmc Genetic dissection of cadherin function during nephrogenesis
    Ulf Dahl
    Department of Medical Biochemistry, Goteborg University, S 405 30 Goteborg, Sweden
    Mol Cell Biol 22:1474-87. 2002
  10. ncbi Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina
    Michael I Dorrell
    Departmentof Cell BIology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 103:3420-7. 2004

Research Grants

Scientific Experts

  • Ullrich Treubert-Zimmermann
  • D R Allan
  • X Liu
  • S Seshadri
  • Jiankai Luo
  • Qin Liu
  • C Redies
  • Kaichun Wu
  • Daniel Moreno de Lucca
  • Johannes Etzrodt
  • Eiji Matsunaga
  • Yasuyuki Shibuya
  • K Niitsuma
  • Henrik Fagman
  • I J Chalmers
  • Simon C Waller
  • James A Marrs
  • Rachel B Hazan
  • David P Gardner
  • Dario Campana
  • Peter Igarashi
  • GRANT MASTICK
  • Andrew Mesecar
  • GERALD GRUNWALD
  • Stuart Ozer
  • Robin R Gutell
  • Xin Yan
  • Honglin Li
  • Jianchun Wu
  • Franck Comunale
  • Cécile Gauthier-Rouvière
  • Camille Miller
  • Sunny Sun Kin Chan
  • Jian Xie
  • Hui Xu
  • Cédric Plutoni
  • Yunzhen Gao
  • Isabel Martinez-Garay
  • M Zhang
  • Maria Inês Alvelos
  • Myriam Catalano
  • Deepak Kumar
  • I Appolloni
  • P Wang
  • Emmanuel Wenger
  • Pietro Palumbo
  • Wei Qian
  • Zhufeng Yang
  • Sophie Charrasse
  • Lin Zhou
  • G Athanasiadis
  • Caroline Poitou
  • Noriko Takahashi
  • Lei Shang
  • Yinghua Zhang
  • Mei Ren Pan
  • Trevi A Ramirez
  • Huiping Wang
  • A Mauray
  • Leslie Huber
  • Weijia Xu
  • Rory Johnson
  • Tarja Niini
  • Tabetha M Bonacci
  • Junjie Liu
  • K Krishna-K
  • Nicole Hertel
  • Chunping Du
  • Guohua Lei
  • Rochelle Naylor
  • Juntang Lin
  • Changqing Su
  • Arndt Rolfs
  • Samantha A Oblander
  • Mi Ryung Han
  • Margaret Anne Craig
  • Varun Aggarwal
  • Semra Demokan
  • Daniel Moreno-De-Luca
  • Yi Zhi Chen
  • Pengyu Ren
  • M Takeichi
  • Haili Li
  • Li Zou
  • Coralie Bingham
  • M Teresa Rodríguez Monje
  • Sian Ellard
  • Johnny C Wu
  • Cindy Banh
  • Juming Ma

Detail Information

Publications127 found, 100 shown here

  1. ncbi R-cadherin influences cell motility via Rho family GTPases
    Emhonta Johnson
    Department of Oral Biology, College of Dentistry, Eppley Institute for Research in Cancer and Allied Diseases, and Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 279:31041-9. 2004
    ..In addition, we show that R-cadherin induces cell motility when expressed in epithelial cells and that this increased motility is dependent upon Rho GTPase activity...
  2. ncbi Co-ordinated expression of phycobiliprotein operons in the chromatically adapting cyanobacterium Calothrix PCC 7601: a role for RcaD and RcaG
    Sanaa Noubir
    Dynamique des Membranes Végétales, Complexes Protéines Pigments, CNRS UMR 8543, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Mol Microbiol 43:749-62. 2002
    ..PCC 7601 the cpc2 operon encoding phycocyanin 2 (PC2) is expressed if red radiations are available. RcaD was previously identified in extracts from red-light-grown cells as an alkaline phosphatase-sensitive protein that ..
  3. ncbi Differential expression of cadherin-2 and cadherin-4 in the developing and adult zebrafish visual system
    Q Liu
    Department of Biology, University of Akron, Ohio 44325 3908, USA
    Vis Neurosci 18:923-33. 2001
    ..methods, and we compared Cdh2 distribution to that of the previously reported and closely related cadherin-4 (Cdh4, R-cadherin)...
  4. ncbi Targeting axons to specific fiber tracts in vivo by altering cadherin expression
    Ullrich Treubert-Zimmermann
    Institute of Anatomy, University of Essen Medical School, D 45122 Essen, Germany
    J Neurosci 22:7617-26. 2002
    ..This is the first direct evidence that cadherins mediate differential axonal pathfinding in vivo, possibly by a preferentially homotypic adhesive mechanism...
  5. ncbi Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafish
    Q Liu
    Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
    Exp Neurol 177:396-406. 2002
    ..In this study, we examined expression of zebrafish cadherin-2 (Cdh2, N-cadherin) and cadherin-4 (Cdh4, R-cadherin) in the visual system of adult zebrafish after eye or optic nerve lesions using immunocytochemistry and ..
  6. pmc Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue
    S Suzuki
    Department of Ophthalmology, University of Southern California, School of Medicine, Los Angeles 90033
    Cell Regul 2:261-70. 1991
    ..These findings show that the cadherin family of adhesion molecules is much larger than previously thought, and suggest that the new cadherins may play an important role in cell-cell interactions within the central nervous system...
  7. ncbi Expression of cadherin-11 delineates boundaries, neuromeres, and nuclei in the developing mouse brain
    Y Kimura
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Dyn 206:455-62. 1996
    ..We also discussed the possibility that cad11 might be involved in neuronal connections between specific nuclei...
  8. doi Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication-competent adenovirus or etoposide
    Xinjian Liu
    Experimental Center, First People s Hospital, Shanghai Jiaotong University, 85 Wu Jin Road, Shanghai, China
    Hum Gene Ther 21:157-70. 2010
    ..To improve viral gene delivery we coinfected the therapeutic adenovirus with a replication-competent adenovirus (RCAd) at low doses that enhanced the transduction efficiency of the former virus...
  9. pmc Genetic dissection of cadherin function during nephrogenesis
    Ulf Dahl
    Department of Medical Biochemistry, Goteborg University, S 405 30 Goteborg, Sweden
    Mol Cell Biol 22:1474-87. 2002
    ..Surprisingly, however, in none of the compound knockout strains was kidney development affected to a greater extent than within the individual cadherin knockout strains...
  10. ncbi Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina
    Michael I Dorrell
    Departmentof Cell BIology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 103:3420-7. 2004
    ..Thus, R-cadherin antagonists may be useful in the treatment of neovascular diseases in which circulating HSCs contribute to abnormal angiogenesis...
  11. pmc Cadherin-4 plays a role in the development of zebrafish cranial ganglia and lateral line system
    Amy L Wilson
    Department of Biology, University of Akron, Akron, OH 44325 3908, USA
    Dev Dyn 236:893-902. 2007
    ..Cadherin-4 (Cdh4) function in the formation of these structures in zebrafish was studied using morpholino antisense technology...
  12. pmc Differential expression of photoreceptor-specific genes in the retina of a zebrafish cadherin2 mutant glass onion and zebrafish cadherin4 morphants
    Q Liu
    Department of Biology, University of Akron, 302 Buchtel Common, Akron, OH 44325, USA
    Exp Eye Res 84:163-75. 2007
    ..Our results suggest that cadherin2 and cadherin4 play important roles in the differentiation of zebrafish retinal photoreceptors...
  13. ncbi A potential role of R-cadherin in striated muscle formation
    P Rosenberg
    Department of Microbiology, Umea University, Sweden
    Dev Biol 187:55-70. 1997
    ....
  14. ncbi Developmental changes in the subcellular localization of R-cadherin in chick retinal pigment epithelium
    X Liu
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Kyoto University, Japan
    Histochem Cell Biol 108:35-43. 1997
    ....
  15. pmc Expression of classical cadherins in the cerebellar anlage: quantitative and functional aspects
    Michael Gliem
    Anatomisches Institut, Anatomie and Zellbiologie, Rheinischen Friedrich, Wilhelms, Universitat, Nussalle 10, D 53115 Bonn, Germany
    Mol Cell Neurosci 33:447-58. 2006
    ..A. and Steinberg, M.S., 2005. The differential adhesion hypothesis: a direct evaluation. Dev. Biol. 278, 255-263.)...
  16. ncbi [An early detection of recurrence using reverse transcriptase-polymerase chain reaction (RT-PCR) and methylation-specific polymerase chain reaction (MSP) from peripheral blood in patients after gastrectomy]
    Nobuyuki Tani
    Division of Digestive Surgery, Dept of Surgery, Kyoto Prefectural University of Medicine
    Gan To Kagaku Ryoho 33:1720-2. 2006
    ..of the promoter region of at least one gene (3 patients for p16, 3 for E-cadherin, 3 for RARbeta genes, and 1 for CDH4 respectively). No abnormal signal was detected in sera from volunteers who served as controls...
  17. ncbi Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal disease
    Emma L Edghill
    1Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Nephrol Dial Transplant 23:627-35. 2008
    ..phenotype is renal cysts, which is frequently associated with early-onset diabetes in the renal cysts and diabetes (RCAD) syndrome. HNF-1beta gene deletions have recently been shown to cause renal malformations and early-onset diabetes.
  18. doi E2F promoter-regulated oncolytic adenovirus with p16 gene induces cell apoptosis and exerts antitumor effect on gastric cancer
    Juming Ma
    Department of Internal Medicine, 117 Hospital of Chinese People s Liberation Army, Hangzhou, People s Republic of China
    Dig Dis Sci 54:1425-31. 2009
    Replication-competent adenovirus (RCAd) constitutes an alternative in cancer therapy...
  19. pmc Loss of retinal cadherin facilitates mammary tumor progression and metastasis
    Georgia Agiostratidou
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cancer Res 69:5030-8. 2009
    ..Here, we show that another cadherin, retinal cadherin (R-cad), is critical for maintenance of the epithelial phenotype...
  20. pmc Distinct PTPmu-associated signaling molecules differentially regulate neurite outgrowth on E-, N-, and R-cadherin
    Samantha A Oblander
    Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA
    Mol Cell Neurosci 44:78-93. 2010
    ..In summary, distinct PTPmicro-associated signaling proteins are required to promote neurite outgrowth on cadherins...
  21. doi Regional expression of the ADAMs in developing chicken cochlea
    Xin Yan
    Albrecht Kossel Institute for Neuroregeneration, School of Medicine, University of Rostock, D 18147 Rostock, Germany
    Dev Dyn 239:2256-65. 2010
    ..The expression of the ADAMs in the developing cochlea suggests a contribution of the ADAMs to the development of distinct cochlear structures...
  22. pmc Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia
    Daniel Moreno-De-Luca
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 87:618-30. 2010
    ..4 Mb deletion at 17q12, which harbors HNF1B, the gene responsible for renal cysts and diabetes syndrome (RCAD), in 18/15,749 patients, including several with ASD, but 0/4,519 controls...
  23. doi Cadherin expression in the somatosensory cortex: evidence for a combinatorial molecular code at the single-cell level
    K Krishna-K
    University of Jena School of Medicine, Teichgraben 7, D 07743 Jena, Germany
    Neuroscience 175:37-48. 2011
    ..In the present study, we mapped in situ the expression pattern of five classic cadherins (Cdh4, Cdh6, Cdh7, Cdh8, Cdh11) and eight δ-protocadherins (Pcdh1, Pcdh7, Pcdh8, Pcdh9, Pcdh10, Pcdh11, Pcdh17 and ..
  24. doi HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system
    Leslie Huber
    Research Group Developmental Neurobiology, Max Planck Institute for Brain Research, Frankfurt Main, Germany
    Dev Biol 363:219-33. 2012
    ..Other subtype-specific properties like RGS4 and RCad are not induced...
  25. pmc A genome-wide screen for genetic variants that modify the recruitment of REST to its target genes
    Rory Johnson
    Stem Cell and Developmental Biology Group, Genome Institute of Singapore, Singapore, Singapore
    PLoS Genet 8:e1002624. 2012
    ..Amongst the targets of polymorphic RE1 elements are important disease genes including NPPA, PTPRT, and CDH4. Thus, considerable genetic variation exists in the DNA motifs that connect gene regulatory networks...
  26. pmc An Accurate Scalable Template-based Alignment Algorithm
    David P Gardner
    Institute for Cellular and Molecular Biology The University of Texas at Austin Austin, TX, USA
    Proceedings (IEEE Int Conf Bioinformatics Biomed) 2012:1-7. 2012
    ..We have developed a program that utilizes the different dimensions of information in rCAD, a large RNA informatics resource, to establish a profile for each position in an alignment...
  27. pmc A novel mutation of the HNF1B gene associated with hypoplastic glomerulocystic kidney disease and neonatal renal failure: a case report and mutation update
    Maria Inês Alvelos
    From the CICS UBI, Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, Covilha, Portugal MIA, MCL Paediatric Nephrology and Renal Transplantation Unit, Department of Paediatrics, Santa Maria Hospital, Lisbon, Portugal MR, CS Department of Radiology, Santa Maria Hospital, Lisbon, Portugal LL and Genetics Unit, Department of Paediatrics, Santa Maria Hospital, Lisbon, Portugal AM, ABS
    Medicine (Baltimore) 94:e469. 2015
    ..Heterozygous germline mutations of HNF1B are associated with the renal cysts and diabetes syndrome (RCAD)...
  28. pmc Transcriptomic profiling of Arabidopsis thaliana mutant pad2.1 in response to combined cold and osmotic stress
    Deepak Kumar
    Plant Biology Laboratory, Drug Development Diagnostics and Biotechnology Division, CSIR Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata, 700032, India
    PLoS ONE 10:e0122690. 2015
    ..noted down-regulation of UDP-glycosyl transferase, 4-coumarate CoA ligase 8, cinnamyl alcohol dehydrogenase 4 (CAD4), ACC synthase and ACC oxidase which are the important enzymes of phenylpropanoid, lignin and ethylene (ET) ..
  29. pmc Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm
    Sunny Sun Kin Chan
    Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Stem Cell Reports 6:26-34. 2016
    ..myogenic progenitors, and discover surface markers to distinguish cardiac (PODXL+) from the skeletal muscle (CDH4+) CPM derivatives...
  30. pmc Cadherin 2/4 signaling via PTP1B and catenins is crucial for nucleokinesis during radial neuronal migration in the neocortex
    Isabel Martinez-Garay
    Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    Development 143:2121-34. 2016
    ..Here, we show that cadherin 2 (CDH2) and CDH4 cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and α- and β..
  31. doi Long non-coding RNA linc-cdh4-2 inhibits the migration and invasion of HCC cells by targeting R-cadherin pathway
    Yunzhen Gao
    The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, PR China The Liver Center of Fujian Province, Fujian Medical University, Fuzhou 350025, PR China
    Biochem Biophys Res Commun 480:348-354. 2016
    ..Linc-cdh4-2 (TCONS_00027978) is a novel LncRNA that has been identified in HCC tissues from our previous study...
  32. pmc The cadherin-binding specificities of B-cadherin and LCAM
    C Murphy-Erdosh
    Department of Physiology, University of California, San Francisco 94143 0724, USA
    J Cell Biol 129:1379-90. 1995
    ..These data suggest that heterophilic interactions between B-cadherin and LCAM are important during avian morphogenesis and help identify the amino acids in the binding domain that determine cadherin specificity...
  33. pmc E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    J Hülsken
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 127:2061-9. 1994
    ....
  34. ncbi Cadherin expression coincides with birth dating patterns in patchy compartments of the developing chicken telencephalon
    Dominik Heyers
    Institute of Anatomy, University of Essen School of Medicine, D 45122 Essen, Germany
    J Comp Neurol 460:155-66. 2003
    ..This mechanism possibly involves the differential expression of adhesive factors, such as cadherins...
  35. pmc R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons
    Gracie L Andrews
    Department of Biology, Cell and Molecular Biology Graduate Program, University of Nevada, Reno, Nevada 89557, USA
    J Neurosci 23:9873-80. 2003
    ..errors occur in a region of the ventral thalamus in which the expression of the cell adhesion molecule R-cadherin (Cdh4) is lost in Pax6 mutants. In vitro, an R-cadherin substrate promoted pioneer axon outgrowth...
  36. ncbi Endothelial cadherins and tumor angiogenesis
    Ugo Cavallaro
    IFOM FIRC Institute of Molecular Oncology, Italy
    Exp Cell Res 312:659-67. 2006
    ..T cadherin, R-cadherin and VE-cadherin 2 were found in specific regions of the vascular tree but their role in vascular development or angiogenesis is still unclear...
  37. ncbi N-/R-cadherin expression in dorsal root ganglia and spinal cord
    Yasuyuki Shibuya
    Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine
    Kobe J Med Sci 51:35-40. 2005
    ..These findings indicate the possibility that expression pattern of cadherins in the peripheral neuron differs with its functional property (e.g. sensory or motor)...
  38. pmc Profilin-1 overexpression restores adherens junctions in MDA-MB-231 breast cancer cells in R-cadherin-dependent manner
    Li Zou
    Department of Bioengineering, University of Pittsburgh, 306 Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, USA
    Cell Motil Cytoskeleton 66:1048-56. 2009
    ..These findings highlight important role of Pfn1 in the regulation of epithelial cell-cell adhesion...
  39. pmc Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat
    Margaret Anne Craig
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK
    J Mol Cell Cardiol 48:1121-8. 2010
    ..Therefore, remodelling of the intercalated disc in the hearts of SHRSP animals may contribute to the altered function observed in these animals...
  40. doi Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells
    Haili Li
    Department of Obstetrics and Gynecology, Oita University Faculty of Medicine, Oita, Japan
    Cancer Lett 297:198-206. 2010
    ..Of the gene expression changes induced by TPL treatment, up-regulation of LRAP, CDH4, and SFRP1 and down-regulation of cystatin, TNNT 1, and L1-CAM were confirmed using Western blot analysis in all ..
  41. doi A novel immunocompetent murine tumor model for the evaluation of RCAd-enhanced RDAd transduction efficacy
    Huiping Wang
    Experimental Research Center, First People s Hospital, School of Medicine, Shanghai Jiaotong University, 85 Wujin Road, Shanghai 200080, China
    Tumour Biol 33:1245-53. 2012
    ..In this study, we tested whether human replication-competent adenovirus (RCAd) can replicate in T739 mouse bladder transitional tumor cells (BTT) and lung adenocarcinoma cells (LA795), and ..
  42. doi Homozygous deletions of cadherin genes in chondrosarcoma-an array comparative genomic hybridization study
    Tarja Niini
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Cancer Genet 205:588-93. 2012
    ..Deletions were also found to affect genes of the cadherin family, including CDH4 and CDH7, each of which had a targeted homozygous loss in one case, and CDH19, which had a targeted homozygous loss ..
  43. pmc Genome-wide landscapes of human local adaptation in Asia
    Wei Qian
    Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 8:e54224. 2013
    ..Notable examples, such as FOXQ1, MAST2, and CDH4, were found to play a role in hair follicle development and human cancer, signal transduction, and tumor repression,..
  44. doi Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis
    Lin Zhou
    3Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology, West Changle Road, Xi an 710032, China K W
    FASEB J 27:4929-39. 2013
    ..through the direct targeting of its 3'-UTR, and this effect in turn reactivated the slit homologue 3 (Slit3), cadherin 4 (CDH4), and runt-related transcription factor 3 (RUNX3) genes via promoter demethylation...
  45. doi The prognostic value of P-cadherin in non-muscle-invasive bladder cancer
    P Wang
    Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China
    Eur J Surg Oncol 40:255-9. 2014
    ..This research aims to specify the prognostic value of P-cadherin on recurrence and progression in non-muscle-invasive bladder cancers (NMIBC)...
  46. doi Variable phenotype in 17q12 microdeletions: clinical and molecular characterization of a new case
    Pietro Palumbo
    Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy Department of Biology, University of Bari, Bari, Italy
    Gene 538:373-8. 2014
    ..HNF1B) gene, as well as point mutations of this gene, are associated with the Renal Cysts and Diabetes syndrome (RCAD, OMIM 137920) and genitourinary alterations...
  47. doi A cadherin switch underlies malignancy in high-grade gliomas
    I Appolloni
    U O Trasferimento Genico, IRCCS AOU San Martino IST, Largo Rosanna Benzi 10, Genoa, Italy
    Oncogene 34:1991-2002. 2015
    ..is caused by an unusual mechanism of cadherin switch, involving the replacement of N-cadherin with R-cadherin (Rcad) at the cell-cell junctions and the activation of ERK and p27...
  48. doi XPAD X-ray hybrid pixel detector for charge density quality diffracted intensities on laboratory equipment
    Emmanuel Wenger
    Université de Lorraine, CRM2, UMR 7036, Vandoeuvre lès Nancy F 54506, France
    Acta Crystallogr B Struct Sci Cryst Eng Mater 70:783-91. 2014
    ..Deformation electron densities are compared to those already published (based on data collected with CCD APEXII and CAD4 diffractometers).
  49. pmc RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis
    M Zhang
    Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Cell Death Differ 22:1922-34. 2015
    ..b>RCAD/Ufl1 (also known as KIAA0776, NLBP and Maxer) was reported to function as a Ufm1 E3 ligase in ufmylation (Ufm1-..
  50. doi Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells
    Myriam Catalano
    Istituto Pasteur Fondazione Cenci Bolognetti and Department of Physiology and Pharmacology, Sapienza University of Rome, Italy Neuromed IRCCS, Via Atinese, Pozzilli, Italy
    Mol Oncol 9:1612-25. 2015
    ....
  51. pmc P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces
    Cédric Plutoni
    Centre de Recherche de Biochimie Macromoleculaire, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5237, Universites Montpellier, 34293 Montpellier, France
    J Cell Biol 212:199-217. 2016
    ..Thus, we identify a specific role of P-cadherin through β-PIX-mediated Cdc42 activation in the regulation of cell polarity and force anisotropy that drives CCM. ..
  52. pmc Identification of the First Riboflavin Catabolic Gene Cluster Isolated from Microbacterium maritypicum G10
    Hui Xu
    From the Department of Chemistry, Texas A and M University, College Station, Texas 77843
    J Biol Chem 291:23506-23515. 2016
    ..RcaA, RcaB, RcaD, and RcaE were overexpressed and biochemically characterized as riboflavin kinase, riboflavin reductase, ribokinase,..
  53. pmc CDH4 suppresses the progression of salivary adenoid cystic carcinoma via E-cadherin co-expression
    Jian Xie
    Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou, China
    Oncotarget 7:82961-82971. 2016
    The cadherin-4 gene (CDH4) of the cadherin family encodes non-epithelial R-cadherin (R-cad); however, the function of this gene in different types of cancer remains controversial...
  54. doi RCAD/BiP Pathway is Necessary for the Proper Synthesis of Digestive Enzymes and the Secretory Function of the Exocrine Pancreas
    Camille Miller
    Augusta University
    Am J Physiol Gastrointest Liver Physiol . 2017
    ..Among the components of the Ufm1 system, Regulator of C53 and DDRGK1 (RCAD) has recently been identified as an Ufm1-specific E3 ligase that promotes ufmylation of DDRGK1, a RCAD-interacting ..
  55. ncbi Expression of calcium-binding proteins in the mouse claustrum
    M Angeles Real
    Departamento de Biologia Celular, Genética y Fisiología, Universidad de Malaga, Campus de Teatinos, 29071, Malaga, Spain
    J Chem Neuroanat 25:151-60. 2003
    ..In this sense, we propose that a specific zone of the dorsal claustrum with cell bodies that strongly express Rcad and cadherin-8 would be the selective target for parvalbumin-expressing fibers, and that they would be mostly ..
  56. pmc Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment
    Mei Ren Pan
    Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA
    J Biol Chem 287:6764-72. 2012
    ..Taken together, our findings identify an important role of CHD4 in controlling HR repair to maintain genome stability and establish the potential therapeutic implications of targeting CHD4 deficiency in tumors...
  57. doi Maturity onset diabetes of the young: clinical characteristics and outcome after kidney and pancreas transplantation in MODY3 and RCAD patients: a single center experience
    Caroline Poitou
    Service de Nephrologie, Dialyse et Transplantation, IFRNT, Hopital Bicetre, Le Kremlin Bicetre, France
    Transpl Int 25:564-72. 2012
    ..Four HNF1A (MODY3) and eight HNF1B mutations [renal cysts and diabetes (RCAD)] were identified. All MODY3 patients had diabetic nephropathy, but only 50% of RCAD patients...
  58. pmc Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses
    Trevi A Ramirez
    Barshop Institute of Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Hypertens Res 35:811-8. 2012
    ..Out of the 168 inflammatory, extracellular matrix and adhesion molecule genes evaluated, Ltb, Cdh4, Col5a1, Ecm1, MMP-11 and TIMP-2 increased in the LV (range: 87-138%), whereas Tnfrsf1a decreased 27%, indicating ..
  59. pmc Structural constraints identified with covariation analysis in ribosomal RNA
    Lei Shang
    Institute for Cellular and Molecular Biology, Center for Computational Biology and Bioinformatics, The University of Texas at Austin, Austin, Texas, USA
    PLoS ONE 7:e39383. 2012
    ..method (PEC) for quantifying positional covariation with the Gutell lab's new RNA Comparative Analysis Database (rCAD). The PEC and MI-based methods each identify unique base pairs, and jointly identify many other base pairs...
  60. doi Effects of G250 promoter controlled conditionally replicative adenovirus expressing Ki67-siRNA on renal cancer cell
    Junjie Liu
    Laboratory of Urology, Affiliated Hospital of Xuzhou Medical College, China
    Cancer Sci 103:1880-8. 2012
    Replication-competent adenovirus (RCAd) has been used extensively in cancer gene therapy, and tumor-selection is critical for the use of replication-competent adenovirus...
  61. pmc Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking
    Yinghua Zhang
    Department of Biochemistry and Molecular Biology, Cancer Center, Georgia Health Sciences University, Augusta, Georgia, United States of America
    PLoS ONE 7:e48587. 2012
    ..In this report we present the evidence for involvement of RCAD/Ufl1, a putative Ufm1-specific E3 ligase, and its binding partner C53/LZAP protein in ufmylation of endogenous Ufm1 ..
  62. pmc De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity
    Zhufeng Yang
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 140:1774-84. 2013
    ....
  63. ncbi Variation in cadherins and catenins expression is linked to both proliferation and transformation of Rhabdomyosarcoma
    Sophie Charrasse
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UPR 1086, 1919 Route de Mende, 34293 Montpellier Cedex, France
    Oncogene 23:2420-30. 2004
    ..In addition, our data suggest that R-cadherin is a specific diagnostic marker for RMS and is also an important factor of RMS cell proliferation...
  64. doi Small GTPase Rho regulates R-cadherin through Dia1/profilin-1
    Tabetha M Bonacci
    Division of Monoclonal Antibodies, Office of Biotechnology Products, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA
    Cell Signal 24:2102-10. 2012
    ..Additionally, our data suggest an inverse relationship between EGFR signaling and R-cadherin adherens junction formation. Taken together, results from this study indicate that R-cadherin is a critical regulator of epithelial phenotype...
  65. doi Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain
    G Athanasiadis
    Unit of Genomics of Complex Diseases, Research Institute, Hospital de Santa Creu i Sant Pau, Barcelona, Spain
    J Thromb Haemost 11:521-8. 2013
    ..Plasma β2 -GPI levels have a significant genetic component (heritability of ~ 80%)...
  66. doi Differential cadherin expression in the developing postnatal telencephalon of a New World monkey
    Eiji Matsunaga
    Laboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, Wako, 351 0198, Japan
    J Comp Neurol 521:4027-60. 2013
    ..In this study, in situ hybridization analysis was performed for 10 cadherins [nine classic cadherins (Cdh4, -6, -7, -8, -9, -10, -11, -12, and -20) and T-cadherin (Cdh13)] in the developing postnatal telencephalon of the ..
  67. ncbi [Relations between social defense and criminological trends from the 1930s until today]
    F Tagliarini
    Quad Criminol Clin 18:289-352. 1976
    ....
  68. pmc Genomic structure and chromosomal mapping of the mouse N-cadherin gene
    S Miyatani
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Proc Natl Acad Sci U S A 89:8443-7. 1992
    ..The E- and P-cadherin genes are tightly linked and located on chromosome 8 in this species. Thus, N-cadherin is unlinked to these other cadherin loci...
  69. ncbi R-cadherin: a novel Ca(2+)-dependent cell-cell adhesion molecule expressed in the retina
    H Inuzuka
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Neuron 7:69-79. 1991
    ..The pattern of the expression of R-cadherin was different from that of N-cadherin, suggesting distinctive roles in retinal morphogenesis...
  70. ncbi Mouse R-cadherin: expression during the organogenesis of pancreas and gastrointestinal tract
    A Sjodin
    Department of Microbiology, University of Umea, Sweden
    Exp Cell Res 221:413-25. 1995
    ..The subcellular localization in these tissues is on both the apical and basolateral surfaces. The potential function of R-cadherin, in particular its role in pancreas development, is discussed...
  71. ncbi Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos
    Y Kimura
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 169:347-58. 1995
    ..These results suggest that cad-11 is involved in specific associations of subsets of mesenchymal cells and also of some neural cells during early embryogenesis...
  72. ncbi Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressed
    C M Williamson
    MRC Radiobiology Unit, Didcot, Oxon, UK
    Genet Res 65:83-93. 1995
    ..and Ntsr) where a defect could lead to neurological and probably behavioural problems, and 3 genes (Cd40, Plcg1 and Rcad) that are less obvious candidates but sequence information was available for designing primers to test their ..
  73. ncbi Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue
    J C Hutton
    Department of Biochemistry and Biophysics, University of California San Francisco 94143 0534
    Mol Endocrinol 7:1151-60. 1993
    ..Differences in CAD expression might explain the segregation of exocrine and endocrine cells during development of the pancreas and the characteristic morphological distribution of the different endocrine cells within the islet...
  74. ncbi Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene
    H Matsunami
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    J Cell Sci 106:401-9. 1993
    ..Thus, the cell binding specificity of R-cadherin is entirely conserved between the two species, suggesting a conserved role for this protein in morphogenesis. We also located the mouse R-cadherin gene to chromosome 2...
  75. ncbi Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion
    H Matsunami
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 172:466-78. 1995
    ..These results suggest that cadherins confer region-specific adhesiveness on fetal brain cells and that this process may take part in brain segmentation...
  76. ncbi Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain
    A Stoykova
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Development 124:3765-77. 1997
    ..These data suggest a link between the transcription factor, Pax6, R-cadherin expression, cellular adhesion and boundary formation between developing forebrain regions...
  77. pmc Dynamic interaction of PTPmu with multiple cadherins in vivo
    S M Brady-Kalnay
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio 44106 4960, USA
    J Cell Biol 141:287-96. 1998
    ..Our data reinforce the observation of an interaction between PTPmu and E-cadherin in vitro and in vivo, further emphasizing the potential importance of reversible tyrosine phosphorylation in regulating cadherin function...
  78. ncbi Involvement of R-cadherin in the early stage of glomerulogenesis
    S Goto
    Department of Medicine II, Niigata University School of Medicine, Japan
    J Am Soc Nephrol 9:1234-41. 1998
    ..These findings indicate that R-cadherin is uniquely expressed in differentiating VEC, suggesting an important role in the early stages of glomerulogenesis...
  79. ncbi Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma
    I J Chalmers
    Institut fur Pathologie, GSF Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany
    Genomics 57:160-3. 1999
    ..A cadherin gene cluster consisting of three genes was identified on the short arm of chromosome 5. This region of the genome is subjected to frequent allelic loss in malignant disease...
  80. ncbi Spatial correspondence between R-cadherin expression domains and retinal ganglion cell axons in developing zebrafish
    Q Liu
    Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor 48109, USA
    J Comp Neurol 410:290-302. 1999
    ..These results demonstrate that R-cadherin is appropriately distributed to play a role in regulating development of the zebrafish visual system, and in particular, pathfinding and synaptogenesis of retinal ganglion cell axons...
  81. ncbi R-cadherin expression in the developing and adult zebrafish visual system
    Q Liu
    Department of Anatomy and Cell Biology, 4610 Medical Science II, University of Michigan, Ann Arbor 48109, USA
    J Comp Neurol 410:303-19. 1999
    ..These results suggest that R-cadherin-mediated adhesion plays a role in development and maintenance of neuronal connections in zebrafish visual system...
  82. ncbi Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain
    M Rhinn
    IGBMC, CNRS INSERM Universite Louis Pasteur, B P 163, C U de Strasbourg, France
    Development 126:4295-304. 1999
    ..Altogether, this study demonstrates that Otx2 is an important regulator of brain patterning and morphogenesis, through its regulation of candidate target genes such as Rpx/Hesx1, Wnt1, R-cadherin and ephrin-A2...
  83. ncbi Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3
    P Kools
    Molecular Cell Biology Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology VIB, Ghent, Belgium
    Cytogenet Cell Genet 86:26-7. 1999
  84. pmc Functional cis-heterodimers of N- and R-cadherins
    W S Shan
    Department of Biochemistry and Molecular Biology, Program in Cell Adhesion, The Mount Sinai School of Medicine, New York University, New York 10029, USA
    J Cell Biol 148:579-90. 2000
    ..The present study provides a novel paradigm for cadherin interaction whereby selective cis-heterodimer formation may generate new functional units to mediate cell-cell adhesion...
  85. ncbi Differential regulation of cadherins by dexamethasone in human osteoblastic cells
    F Lecanda
    Division of Bone and Mineral Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 77:499-506. 2000
    ..Dexamethasone effects on certain osteoblast differentiated features, such as induction of alkaline phosphatase activity are not strictly dependent on cadherin function...
  86. ncbi Mutation analysis of cadherin-4 reveals amino acid residues of EC1 important for the structure and function
    M Kitagawa
    Department of Clinical Research, Okura National Hospital, Okura, Tokyo, 157 8535, Japan
    Biochem Biophys Res Commun 271:358-63. 2000
    ..the effects of point mutations of well-conserved amino acid residues in the extracellular domain 1 of cadherin-4 (Cdh4) on the adhesion properties by alanine scanning mutagenesis...
  87. ncbi Morphologic fate of diencephalic prosomeres and their subdivisions revealed by mapping cadherin expression
    C Redies
    Institute of Anatomy, University Hospital Essen, Germany
    J Comp Neurol 421:481-514. 2000
    ....
  88. ncbi Role of cadherins in maintaining the compartment boundary between the cortex and striatum during development
    T Inoue
    Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Development 128:561-9. 2001
    ..Thus, the differential expression pattern of cadherins in the embryonic telencephalon is responsible for maintaining the cortico-striatal compartment boundary...
  89. ncbi Calcium-dependent adhesion is necessary for the maintenance of prosomeres
    M McCarthy
    Developmental Genetics Program, Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Dev Biol 233:80-94. 2001
    ..Together our results implicate calcium-dependent adhesion molecules as key mediators of prosomeric organization but suggest that they are not sufficient to bestow regional identities...
  90. ncbi High-pressure single-crystal X-ray diffraction facilities on station 9.8 at the SRS Daresbury Laboratory--hydrogen location in the high-pressure structure of ethanol
    D R Allan
    Department of Physics and Astronomy, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JZ, UK
    J Synchrotron Radiat 8:10-7. 2001
    ..The station has been equipped with a modified Enraf-Nonius CAD4 four-circle diffractometer for high-pressure studies which can be conveniently, and rapidly, interchanged with the ..
  91. ncbi Cadherin expression by embryonic divisions and derived gray matter structures in the telencephalon of the chicken
    C Redies
    Institute of Anatomy, University of Essen, School of Medicine, D 45122 Essen, Germany
    J Comp Neurol 438:253-85. 2001
    ..2000])...
  92. ncbi Cadherin-4 expression in the zebrafish central nervous system and regulation by ventral midline signaling
    Q Liu
    Department of Biology, University of Akron, Akron, OH 44325 3908, USA
    Brain Res Dev Brain Res 131:17-29. 2001
    In this study we show that zebrafish cadherin-4 (R-cadherin) transcript (cad4) and protein are expressed in several defined regions in the embryonic forebrain and in distinctive clusters in the hindbrain and spinal cord...
  93. ncbi Severe hyperglycemia after renal transplantation in a pediatric patient with a mutation of the hepatocyte nuclear factor-1beta gene
    Simon C Waller
    Nephro Urology Unit, Institute of Child Health, University College London and the Department of Diabetes and Vascular Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, England
    Am J Kidney Dis 40:1325-30. 2002
    ..The recent description of renal cysts and diabetes (RCAD) syndrome and a strong paternal family history of early-onset diabetes mellitus prompted genetic screening of the ..
  94. ncbi Abnormal splicing of hepatocyte nuclear factor-1 beta in the renal cysts and diabetes syndrome
    L W Harries
    Molecular Genetics, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetologia 47:937-42. 2004
    ..beta) gene result in disorders of renal development, typically involving renal cysts and early-onset diabetes (the RCAD syndrome/ MODY5)...
  95. ncbi R-cadherin:beta-catenin complex and its association with vascular smooth muscle cell proliferation
    Sadie C Slater
    Bristol Heart Institute, Department of Cardiac, Anesthetic, and Radiological Sciences, University of Bristol, Bristol Royal Infirmary, Bristol, UK
    Arterioscler Thromb Vasc Biol 24:1204-10. 2004
    ..Outside-in signaling from the cadherin:beta-catenin complex can increase transcription of the cell-cycle gene cyclin D1; however, its role in VSMC proliferation has only recently been considered...
  96. ncbi Selective synaptic cadherin expression by traced neurons of the chicken visual system
    D Heyers
    Institute of Anatomy, University of Duisburg Essen School of Medicine, D 45122 Essen, Germany
    Neuroscience 127:901-12. 2004
    ..Our findings support the idea that a cadherin-based adhesive mechanism can mediate synaptic specificity...
  97. ncbi Differential expression of cadherins in the developing and adult zebrafish olfactory system
    Qin Liu
    Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
    J Comp Neurol 478:269-81. 2004
    ..We hypothesize that the differential expression of these three cadherins in the developing zebrafish major olfactory structures reflects functionally different roles in the development of the vertebrate olfactory system...
  98. ncbi Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina
    Takaya Miyawaki
    Department of Ophthalmology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Neurosci 24:8124-34. 2004
    ....
  99. ncbi Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer
    Elena Miotto
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Cancer Res 64:8156-9. 2004
    Gene promoter methylation causes loss of tumor suppressor genes function in human cancer. Here, we show that the CDH4 gene, a member of the cadherin family encoding for R-cadherin, contains a CpG island located at the 5' of the first exon,..
  100. ncbi Localization and expression of R-cadherin in skeletal muscle following nerve injury
    K Niitsuma
    Division of Plastic Surgery, Nara Medical University, Nara, Japan
    Eur Surg Res 37:79-84. 2005
    ..In the sutured group, the levels of R-cadherin expression increased and then decreased to almost control values. These results suggest that R-cadherin plays some role in cells of normal and regenerating muscles...
  101. ncbi Zebrafish R-cadherin (Cdh4) controls visual system development and differentiation
    Sherry G Babb
    Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana 56202 5130, USA
    Dev Dyn 233:930-45. 2005
    In zebrafish, R-cadherin (cadherin-4 or Cdh4) is expressed in the retina and in retinorecipient brain regions, suggesting that Cdh4 functions during visual system development...

Research Grants8

  1. Small Molecule X-Ray Diffraction Instrumentation
    Andrew Mesecar; Fiscal Year: 2002
    ..This instrument will replace the slow, aging, and somewhat unreliable CAD4 diffractometer that is housed on the eat campus near Chemistry...
  2. CELL ADHESION IN RETINAL DEVELOPMENT AND PATHOLOGY
    GERALD GRUNWALD; Fiscal Year: 2004
    ..this application are specifically designed to test the central hypothesis that the coordinated regulation of retinal cadherin cell adhesion molecules is critical to the normal growth and differentiation of retinal cells...
  3. IMMUNOGLOBULIN GENE ARRANGEMENT/EXPRESSION IN LEUKEMIA
    Dario Campana; Fiscal Year: 2005
    ..The development of new automated MRD assays and the identification of new markers of leukemia should improve residual disease evaluation and thereby improve risk-directed therapy selection for every child with ALL. ..
  4. Signals Regulating SAG Development
    James A Marrs; Fiscal Year: 2010
    ..Cdh2, Cdh4 and Cdh6 knockdown experiments (nomenclature: gene names cdh2, cdh4, cdh6 and cdh10;and protein names Cdh2, Cdh4, ..
  5. MicroRNA-Based Therapeutics for Rare Cystic Kidney Diseases
    Peter Igarashi; Fiscal Year: 2010
    ..cystic kidney diseases include autosomal recessive polycystic kidney disease (ARPKD), renal cysts and diabetes (RCAD), and nephronophthisis (NPHP)...
  6. R-Cadherin in Breast Cancer Suppression
    Rachel B Hazan; Fiscal Year: 2013
    ..Establishing the clinical relevance of R-cadherin and identifying the segments which mediate suppression could provide leads into signaling pathways and therapeutic strategies to control breast cancer. ..
  7. PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAIN
    GRANT MASTICK; Fiscal Year: 2004
    ..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
  8. Neurotrophic Factors: Genetic Variation and Serum Levels in Brain Aging
    Sudha Seshadri; Fiscal Year: 2010
    ....