CD56

Summary

Gene Symbol: CD56
Description: neural cell adhesion molecule 1
Alias: CD56, MSK39, NCAM, neural cell adhesion molecule 1, antigen recognized by monoclonal antibody 5.1H11, neural cell adhesion molecule, NCAM
Species: human

Top Publications

  1. ncbi Alternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecule
    S Huerta
    Department of Surgery, VA Greater Los Angeles Health Care System UCLA School of Medicine, Los Angeles, CA 90073, USA
    Surgery 130:834-43. 2001
  2. ncbi Bile ducts and ductules are positive for CD56 (N-CAM) in most cases of extrahepatic biliary atresia
    Michael Torbenson
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 27:1454-7. 2003
  3. ncbi PSA-NCAM immunoreactivity in chandelier cell axon terminals of the human temporal cortex
    Jon I Arellano
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Cereb Cortex 12:617-24. 2002
  4. ncbi A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation
    Shalu Shiv Mendiratta
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Biol Chem 281:36052-9. 2006
  5. ncbi HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets
    Maria Giovanna Quaranta
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    FASEB J 21:2323-34. 2007
  6. pmc Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule
    Federico Carafoli
    Department of Life Sciences, Biophysics Section, Blackett Laboratory, Imperial College London, London SW7 2AZ, UK
    J Mol Biol 377:524-34. 2008
  7. ncbi Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals
    Makoto Arai
    Department of Schizophrenia Research, Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Biol Psychiatry 55:804-10. 2004
  8. ncbi Diagnostic value of HBME-1, CD56, Galectin-3 and Cytokeratin-19 in papillary thyroid carcinomas and thyroid tumors of uncertain malignant potential
    Adela Nechifor-Boilă
    Department of Histology, University of Medicine and Pharmacy of Tirgu Mures, Romania
    Rom J Morphol Embryol 55:49-56. 2014
  9. pmc Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A
    Natasja Nielsen
    Translational Immunology, Novo Nordisk A S, Måløv, Denmark
    PLoS ONE 7:e31959. 2012
  10. doi Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells
    Korehito Kashiwagi
    Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Pathol Int 62:232-45. 2012

Research Grants

  1. Natural Killer Cell Receptor Diversity and CMV in Hematopoietic Cell Transplantat
    STEVEN AARON PERGAM; Fiscal Year: 2013
  2. Pediatric Immune Correlates of Early Anti-HIV Therapy
    Luis J Montaner; Fiscal Year: 2010
  3. BIOCHEMICAL CONSEQUENCES OF CELL-CELL CONTACT
    Urs Rutishauser; Fiscal Year: 1990
  4. MOLECULAR DETERMINANTS OF AXON GROWTH
    CARL LAGENAUR; Fiscal Year: 1999
  5. Force Probe Investigations of NCAM Adhesion
    Deborah Leckband; Fiscal Year: 2004
  6. Immunophenotyping and Lymphocyte Effector Functions in Sarcoidosis
    Laura L Koth; Fiscal Year: 2010
  7. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
  8. NK CELL ADCC AND CD4+ CELL APOPTOSIS IN HIV+ TISSUES
    Gail Skowron; Fiscal Year: 2003
  9. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
  10. Rene Hen; Fiscal Year: 2016

Detail Information

Publications654 found, 100 shown here

  1. ncbi Alternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecule
    S Huerta
    Department of Surgery, VA Greater Los Angeles Health Care System UCLA School of Medicine, Los Angeles, CA 90073, USA
    Surgery 130:834-43. 2001
    The neural cell adhesion molecule (NCAM) has numerous isoforms resulting from alternative splicing of mRNA...
  2. ncbi Bile ducts and ductules are positive for CD56 (N-CAM) in most cases of extrahepatic biliary atresia
    Michael Torbenson
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 27:1454-7. 2003
    ..Several previous studies have noted that biliary epithelium is positive for CD56 in the setting of extrahepatic biliary tract disease...
  3. ncbi PSA-NCAM immunoreactivity in chandelier cell axon terminals of the human temporal cortex
    Jon I Arellano
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Cereb Cortex 12:617-24. 2002
    In the adult central nervous system, the expression of polysialylated forms of the cell-surface glycoprotein NCAM (PSA-NCAM) is thought to be confined to areas particularly susceptible to plastic changes...
  4. ncbi A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation
    Shalu Shiv Mendiratta
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Biol Chem 281:36052-9. 2006
    ..acid is a developmentally regulated, anti-adhesive glycan that is added to the neural cell adhesion molecule, NCAM. Polysialylated NCAM is critical for brain development and plays roles in synaptic plasticity, axon guidance, and ..
  5. ncbi HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets
    Maria Giovanna Quaranta
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    FASEB J 21:2323-34. 2007
    ..We demonstrate that Nef up-regulates the ability of DCs to stimulate the immunoregulatory NK cells (CD56(bright)) as assessed by the activated phenotype, up-regulation of their proliferative response and INF-gamma ..
  6. pmc Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule
    Federico Carafoli
    Department of Life Sciences, Biophysics Section, Blackett Laboratory, Imperial College London, London SW7 2AZ, UK
    J Mol Biol 377:524-34. 2008
    Activation of the fibroblast growth factor receptor (FGFR) by neural cell adhesion molecule (NCAM) is essential for NCAM-mediated neurite outgrowth...
  7. ncbi Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals
    Makoto Arai
    Department of Schizophrenia Research, Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Biol Psychiatry 55:804-10. 2004
    ..b>Neural cell adhesion molecule 1 (NCAM1) is known to play important roles in cell migration, neurite growth, axonal guidance, and ..
  8. ncbi Diagnostic value of HBME-1, CD56, Galectin-3 and Cytokeratin-19 in papillary thyroid carcinomas and thyroid tumors of uncertain malignant potential
    Adela Nechifor-Boilă
    Department of Histology, University of Medicine and Pharmacy of Tirgu Mures, Romania
    Rom J Morphol Embryol 55:49-56. 2014
    We aimed to evaluate four immunohistochemical markers (HBME-1, Galectin-3, Cytokeratin-19 and CD56) used alone or in panels in a series of papillary thyroid carcinoma (PTC) and thyroid tumors of uncertain malignant potential (TT-UMP) cases...
  9. pmc Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A
    Natasja Nielsen
    Translational Immunology, Novo Nordisk A S, Måløv, Denmark
    PLoS ONE 7:e31959. 2012
    ..Two subsets of human NK cells can be phenotypically distinguished as CD16(+)CD56(dim) and CD16(dim/-)CD56(bright)...
  10. doi Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells
    Korehito Kashiwagi
    Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Pathol Int 62:232-45. 2012
    b>Neural cell adhesion molecule 1 (NCAM1), synaptophysin (SYPT), and chromogranin A (CGA) are immunohistochemical markers for diagnosing lung neuroendocrine tumors (LNETs)...
  11. ncbi Molecular characterization of eukaryotic polysialyltransferase-1
    M Eckhardt
    Institut fur Medizinische Mikrobiologie, Medizinische Hochschule Hannover, Germany
    Nature 373:715-8. 1995
    ..PSA) is a dynamically regulated product of post-translational modification of the neural cell adhesion molecule, NCAM. Presence of the large anionic carbohydrate modulates NCAM binding properties and, by increasing the intercellular ..
  12. ncbi FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection
    Timothy J Wilson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Blood 109:3786-93. 2007
    ....
  13. ncbi The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system
    L C Rønn
    Protein Laboratory, Institute for Molecular Pathology, University of Copenhagen, Denmark
    Exp Gerontol 33:853-64. 1998
    The neural cell adhesion molecule (NCAM) is a member of the immunoglobulin superfamily and is strongly expressed in the nervous system...
  14. ncbi The fibroblast growth factor receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of neural cell adhesion molecule
    Elena Sanchez-Heras
    Wolfson Centre for Age Related Diseases, King s College London, London SE1 1UL, United Kingdom
    J Biol Chem 281:35208-16. 2006
    Interactions between the neural cell adhesion molecules NCAM and N-cadherin with the fibroblast growth factor receptor (FGFR) are important for a number of developmental events and have also been implicated in tumor progression...
  15. ncbi PSA-NCAM expression in the human prefrontal cortex
    Emilio Varea
    Neurobiology Unit and Program in Basic and Applied Neurosciences, Cell Biology Department, Universitat de Valencia, Dr Moliner 50, Burjassot 46100, Spain
    J Chem Neuroanat 33:202-9. 2007
    ..The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) may mediate these structural changes through its anti-adhesive properties...
  16. pmc Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain
    I Jakovcevski
    Neuroscience Department, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
    Neuroscience 149:328-37. 2007
    ..The polysialic acid (PSA) modification of neural cell adhesion molecule, which reduces neural cell adhesion molecule (NCAM) - mediated cell adhesion, is involved in several developmental processes, such as cell migration, axonal growth, ..
  17. pmc Developmental regulation of neural cell adhesion molecule in human prefrontal cortex
    E T Cox
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuroscience 162:96-105. 2009
    Neural cell adhesion molecule (NCAM) is a membrane-bound cell recognition molecule that exerts important functions in normal neurodevelopment including cell migration, neurite outgrowth, axon fasciculation, and synaptic plasticity...
  18. ncbi Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain
    G Dickson
    Cell 50:1119-30. 1987
    ..7 kb muscle transcript. The MSD1 is also absent from chick and mouse brain mRNAs of 4.0 and 2.9 kb. These results show that diversity in N-CAM primary structure can be found in the extracellular domain in a tissue-specific manner...
  19. ncbi NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn)
    H E Beggs
    Department of Biochemistry, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7260, USA
    J Biol Chem 272:8310-9. 1997
    ..Neurite outgrowth mediated by the neural cell adhesion molecule (NCAM) requires the src family tyrosine kinase p59(fyn) in nerve growth cones, but the molecular basis for this ..
  20. ncbi NCAM regulates cell motility
    Søren Prag
    Protein Laboratory, Institute of Molecular Pathology, University of Copenhagen, Denmark
    J Cell Sci 115:283-92. 2002
    ..We show here that expression of or exposure to the neural cell adhesion molecule (NCAM) strongly affected the motile behaviour of glioma cells independently of homophilic NCAM interactions...
  21. ncbi Costimulation of T cell receptor-triggered IL-2 production by Jurkat T cells via fibroblast growth factor receptor 1 upon its engagement by CD56
    Ferdynand J Kos
    Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA
    Immunol Cell Biol 80:364-9. 2002
    ..While it is known that CD56 is a molecular isoform of NCAM expressed on human NK cells and a subset of T cells, it remains poorly characterized,..
  22. ncbi Expression patterns of PSA-NCAM in the human ganglionic eminence and its vicinity: role of PSA-NCAM in neuronal migration and axonal growth?
    Norbert Ulfig
    Neuroembryonic Research Laboratory, Department of Anatomy, University of Rostock, Rostock, Germany
    Cells Tissues Organs 177:229-36. 2004
    ..To investigate the roles of the highly polysialylated isoform of the neural cell adhesion molecule (PSA-NCAM) in cell migration and axonal growth within the GE and its neighbouring structures, the spatio-temporal expression ..
  23. ncbi CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation
    Nicola Dalbeth
    Division of Medicine, Imperial College London, Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    J Immunol 173:6418-26. 2004
    Human NK cells may be divided into a CD56(dim) subset and a CD56(bright) subset. In peripheral blood, CD56(dim) NK cells dominate, whereas in lymph nodes, CD56(bright) NK cells are more common...
  24. ncbi Induction of CD56 and TCR-independent activation of T cells with aging
    Bonnie H Lemster
    Department of Pediatrics, University of Pittsburgh, PA 15213, USA
    J Immunol 180:1979-90. 2008
    ..Monitoring of T cells driven to senescence showed de novo induction of CD56, the prototypic receptor of NK cells...
  25. pmc Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users
    Li Ye
    Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 5:e9602. 2010
    b>CD56(+) T cells are abundant in liver and play an important role in host innate immunity against viral infections, including hepatitis C virus (HCV) infection, a common infection among heroin abusers...
  26. pmc Functional consequences of the interactions among the neural cell adhesion molecule NCAM, the receptor tyrosine kinase TrkB, and the inwardly rectifying K+ channel KIR3.3
    Ralf Kleene
    Zentrum für Molekulare Neurobiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 85, 20246 Hamburg, Germany
    J Biol Chem 285:28968-79. 2010
    ..3 directly binds to the neural cell adhesion molecule (NCAM) and neurotrophin receptor TrkB...
  27. pmc Neural cell adhesion molecule (NCAM) association with PKCbeta2 via betaI spectrin is implicated in NCAM-mediated neurite outgrowth
    Iryna Leshchyns'ka
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Germany
    J Cell Biol 161:625-39. 2003
    In hippocampal neurons and transfected CHO cells, neural cell adhesion molecule (NCAM) 120, NCAM140, and NCAM180 form Triton X-100-insoluble complexes with betaI spectrin...
  28. ncbi Neuroprotection mediated by subtoxic dose of NMDA in SH-SY5Y neuroblastoma cultures: activity-dependent regulation of PSA-NCAM expression
    Jaspreet Singh
    Department of Biotechnology, Neurochemistry and Neuroendocrinology Lab, Guru Nanak Dev University, Amritsar, Punjab, India
    Brain Res Mol Brain Res 137:223-34. 2005
    ..NMDA receptor stimulation has been shown to regulate polysialylated neural cell adhesion molecule (PSA-NCAM) expression in glial cell cultures and in hippocampal slice cultures...
  29. pmc Isopentenyl pyrophosphate-activated CD56+ {gamma}{delta} T lymphocytes display potent antitumor activity toward human squamous cell carcinoma
    Alan A Z Alexander
    Department of Otorhinolaryngology Head and Neck Surgery, University of Maryland School of Medicine, MD 21201, USA
    Clin Cancer Res 14:4232-40. 2008
    The expression of CD56, a natural killer cell-associated molecule, on alphabeta T lymphocytes correlates with their increased antitumor effector function. CD56 is also expressed on a subset of gammadelta T cells...
  30. ncbi Immunoelectron microscopic localization of the neural recognition molecules L1, NCAM, and its isoform NCAM180, the NCAM-associated polysialic acid, beta1 integrin and the extracellular matrix molecule tenascin-R in synapses of the adult rat hippocampus
    T Schuster
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Hamburg, Germany
    J Neurobiol 49:142-58. 2001
    ..types of long-term potentiation (LTP), may express the immunoglobulin superfamily recognition molecules L1 and NCAM, the extracellular matrix molecule tenascin-R, and the extracellular matrix receptor constituent beta1 integrin in ..
  31. ncbi Polysialylated neural cell adhesion molecules expressed in human pituitary tumors and related to extrasellar invasion
    Jacqueline Trouillas
    Laboratoire d Histologie et d Embryologie moléculaires et Institut National de la Sante et de la Recherche Médicale U433, Faculté de Médecine Lyon RTH Laënnec, Lyon, France
    J Neurosurg 98:1084-93. 2003
    ..The polysialylated neural cell adhesion molecule (NCAM), which is highly expressed in embryonic tissues such as the brain and pituitary, is detected in some and ..
  32. ncbi Disturbed Purkinje cell migration due to reduced expression of Reelin by X-irradiation in developing rat cerebellum
    W Darmanto
    Research Institute of Environmental Medicine, Nagoya University
    Biol Sci Space 12:254-5. 1998
    ..place at the first week after birth of the rat and cell adhesion molecules such as neural cell adhesion molecule (NCAM), fibronectin, tenascin and Reelin are also suggested to play an important role for the cell patterning...
  33. ncbi Immunophenotypes and cytotoxic functions of lymphocytes in patients with hepatocellular carcinoma
    S S Chavan
    Cellular Immunology Unit, Tata Memorial Centre, Parel, Bombay, India
    Tumori 83:762-7. 1997
    ..were phenotyped by single and dual color flow cytometry using monoclonal antibodies specific for CD4, CD8, CD56 and HLA-DR markers...
  34. ncbi [Effects of fluoride on neural cell adhesion molecules mRNA and protein expression levels in primary rat hippocampal neurons]
    Tao Xia
    Department of Occupational and Environmental Health MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Yu Fang Yi Xue Za Zhi 41:475-8. 2007
    To investigate the effects of fluoride on the growth and viability, and mRNA and protein expression levels of neural cell adhesion molecules (NCAM) in primary rat hippocampal neurons.
  35. ncbi CD56 and PGP expression in acute myeloid leukemia: impact on clinical outcome
    Donatella Raspadori
    Department of Hematology, University of Siena, Italy
    Haematologica 87:1135-40. 2002
    ..Recently, we demonstrated that the presence of CD56 antigen, an isoform of the neural adhesion molecule, in AML cells is a negative independent prognostic factor for ..
  36. ncbi Amygdala upregulation of NCAM polysialylation induced by auditory fear conditioning is not required for memory formation, but plays a role in fear extinction
    Kamila Markram
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, Switzerland
    Neurobiol Learn Mem 87:573-82. 2007
    ..We investigate here whether polysialylated NCAM (PSA-NCAM) contributes to auditory fear conditioning in the amygdala...
  37. pmc Identification of a cDNA clone that contains the complete coding sequence for a 140-kD rat NCAM polypeptide
    S J Small
    Division of Basic Research, Children s Hospital Research Foundation, Cincinnati, Ohio 45229
    J Cell Biol 105:2335-45. 1987
    ..In this study, we report the isolation of NCAM clones from an adult rat brain cDNA library...
  38. ncbi Prognostic significance of CD56 antigen expression in acute myeloid leukemia
    Eros Di Bona
    Department of Cellular Therapy and Hematology, Division of Hematology, San Bartolo Hospital, Vicenza, Italy
    Haematologica 87:250-6. 2002
    b>CD56 antigen expression has been reported in several hematologic malignancies...
  39. doi Contribution of neural cell adhesion molecule (NCAM) to hemopoietic system in monkeys
    Junko Kato
    1st Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan
    Ann Hematol 87:797-807. 2008
    Neural cell adhesion molecules (CD56) are important adhesion molecules that are mainly expressed on neural cells and natural killer cells...
  40. doi Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens
    Pau Montesinos
    Hospital Universitario La Fe, Valencia, Spain
    Blood 117:1799-805. 2011
    The expression of CD56 antigen in acute promyelocytic leukemia (APL) blasts has been associated with short remission duration and extramedullary relapse...
  41. ncbi Immunological alterations associated with Plasmodium vivax malaria in South Korea
    H K Lee
    Department of Clinical Pathology, College of Medicine, Catholic University of Korea, 62 Youido dong, Youngdeungpo gu, Seoul, 150 713, South Korea
    Ann Trop Med Parasitol 95:31-9. 2001
    ..Cells of most of the lymphocyte subsets investigated [i.e. CD3+, CD8+, CD19+, CD56+, CD3-/CD56+ and CD8+/CD56+ but not CD4+, CD3+/CD56+ or CD25+] were significantly less common among the lymphocytes ..
  42. ncbi [Hematodermic CD4/CD56 neoplasm]
    Tony Petrella
    Centre de Pathologie, 33 rue Nicolas Bornier, BP189, 21005, Dijon Cedex, France
    Ann Pathol 24:241-55; quiz 227. 2004
    Hematodermic CD4/CD56 neoplasm is a recently described entity...
  43. ncbi Neuroendocrine properties of adrenocortical cells
    M Ehrhart-Bornstein
    National Institute of Health, Bethesda, MD 20892, USA
    Horm Metab Res 30:436-9. 1998
    ..In our studies, the expression of neuronal cell adhesion molecule (NCAM) could be shown in the zona glomerulosa of the normal human adrenal and in the human adrenocortical cell line NCI-..
  44. ncbi Impaired perforin-dependent NK cell cytotoxicity and proliferative activity of peripheral blood T cells is associated with metastatic melanoma
    V Jovic
    Institute for Oncology and Radiology of Serbia, Belgrade
    Tumori 87:324-9. 2001
    ..The aim of this study was to investigate in more detail not only the percentage but also the activation status and function of NK and T cells in patients with metastatic melanoma prior to therapy...
  45. ncbi Benign clear cell tumor of the lung
    T Hashimoto
    Department of Internal Medicine, Mito Saiseikai General Hospital, Ibaraki, Japan
    Ultrastruct Pathol 25:479-83. 2001
    ..A few clear cells were positive for HMB-45 and NCAM 123C3 (CD56)...
  46. ncbi [Increase in perforin-positive peripheral blood lymphocytes in extrinsic and intrinsic asthma]
    V Arnold
    Pneumologische Abteilung, , Deutschland
    Pneumologie 54:468-73. 2000
    ..Lymphocytes were identified using flow cytometry and subdivided into CD3(+), CD4(+), CD8(+), CD16(+), and CD56(+) subpopulations after staining with appropriate monoclonal antibodies...
  47. ncbi CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 26:322-7. 2007
    ..Some types, including granulosa and Sertoli cell tumor, may be confused with a neuroendocrine neoplasm. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and is commonly used as ..
  48. ncbi The neural cell adhesion molecule (NCAM) provides clues to the development of testicular Leydig cells
    A Mayerhofer
    Abteilung Anatomie und Zellbiologie der Universitat, Ulm, Germany
    J Androl 17:223-30. 1996
    ..shown, Leydig cells in culture dramatically up-regulate the expression of the neural cell adhesion molecule (NCAM) gene and express alternatively spliced forms...
  49. ncbi Interferon therapy shifts natural killer subsets among Egyptian patients with chronic hepatitis C
    Amal Fathy
    Department of Clinical Pathology, Suez Canal University, Egypt
    Braz J Infect Dis 14:398-405. 2010
    Natural killer cells can be divided into five subpopulations based on the relative expression of CD16 and CD56 markers. The majority of natural killer cells are CD56(dim), which are considered to be the main cytotoxic effectors...
  50. ncbi Mistletoe lectin I-induced effects on human cytotoxic lymphocytes. I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity
    C N Baxevanis
    Cancer Immunology and Immunotherapy Center, St. Savas Cancer Hospital, Athens, Greece
    Immunopharmacol Immunotoxicol 20:355-72. 1998
    ..NK) and lymphokine-activated killer (LAK) cytotoxicity is mainly mediated by resting (NK) and IL-2-activated (LAK) CD56-positive (+) cells respectively...
  51. ncbi Phenotypic difference of normal plasma cells from mature myeloma cells
    H Harada
    Department of Internal Medicine, Hiroshima University, Japan
    Blood 81:2658-63. 1993
    ..flow cytometry with FITC-anti-CD38 antibody and phycoerythrin staining with antibody to VLA-4, MPC-1, CD44, CD56, CD19, CD20, CD24, or CD10...
  52. ncbi Immunotoxin therapy of small-cell lung cancer: a phase I study of N901-blocked ricin
    T J Lynch
    Hematology Oncology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Clin Oncol 15:723-34. 1997
    ..N901 is a murine monoclonal antibody that binds to the CD56 (neural cell adhesion molecule [NCAM]) antigen found on cells of neuroendocrine origin, including SCLC...
  53. ncbi [Expression of CD56, as a potential diagnostic marker, in small cell carcinoma]
    Jing Ping Yun
    State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, P R China
    Ai Zheng 24:1140-3. 2005
    ..This study was to investigate the expression of CD56, a neural cell adhesion molecule (NCAM), in small cell carcinoma tissues, and to explore the possibility of CD56 as ..
  54. ncbi Expression of neural cell adhesion molecule (NCAM) during the first molar development in the mouse
    N Obara
    Department of Oral Anatomy, School of Dentistry, Higashi Nippon Gakuen University, Hokkaido, Japan
    Anat Embryol (Berl) 187:209-19. 1993
    b>NCAM, the neural cell adhesion molecule, was immunolocalized in the mandibular first molar tooth germ of the mouse...
  55. ncbi alpha-Tocopherol affects neuronal plasticity in adult rat dentate gyrus: the possible role of PKCdelta
    Paola Ferri
    Institute of Morphological Sciences, University of Urbino Carlo Bo, Italy
    J Neurobiol 66:793-810. 2006
    ..Hippocampus dentate gyrus (DG) is characterized by neuronal plasticity processes in adulthood, and polysialylation of NCAM promotes neuronal plasticity...
  56. ncbi Generation of CD3+ CD56+ cytokine-induced killer cells and their in vitro cytotoxicity against pediatric cancer cells
    Suradej Hongeng
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Int J Hematol 77:175-9. 2003
    ..Adoptive cellular immunotherapy with effector cells has the potential to overcome this escape. In adults, the CD3+ CD56+ cell, a cytokine-induced killer (CIK) cell, appears to be a promising effector cell type with the greatest ..
  57. ncbi Simple enumerations of peripheral blood natural killer (CD56+ NK) cells, B cells and T cells have no predictive value in IVF treatment outcome
    M Y Thum
    Lister Fertility Clinic, Lister Hospital, London, UK
    Hum Reprod 20:1272-6. 2005
    To evaluate the association between the absolute counts of the peripheral natural killer (NK) cells (including total CD56(+) NK cells, CD56(dim) NK cells and CD56(bright) NK cells), B cells and T cells on the implantation rate and ..
  58. ncbi Papillary carcinoma of the thyroid: low expression of NCAM (CD56) is associated with downregulation of VEGF-D production by tumour cells
    S Scarpino
    Dipartimento di Medicina Sperimentale, II Facolta di Medicina e Chirurgia, Ospedale Sant Andrea, Universita La Sapienza, Roma, Italy
    J Pathol 212:411-9. 2007
    The expression of NCAM was investigated in tissue sections of 61 cases of papillary carcinoma and in 14 lymph node metastases using immunohistochemistry...
  59. ncbi Sequence of expression of MyoD1 and various cell surface and cytoskeletal proteins in regenerating mouse muscle fibers following treatment with sodium dihydrogen phosphate
    D Figarella-Branger
    Laboratoire de Biopathologie nereuse et musculair JE 2053, Faculte de Medecine, Marseille, France
    J Neurol Sci 165:106-15. 1999
    ..in order to evaluate the sequence of expression of various cell surface proteins [neural cell adhesion molecule (NCAM) and its polysialylated isoform, PSA NCAM, and utrophin], cytoskeletal proteins (myosin heavy chain isoforms, ..
  60. doi Relative role of upstream regulators of Akt, ERK and CREB in NCAM- and FGF2-mediated signalling
    Dorte Kornerup Ditlevsen
    Protein Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Panum Institute, Building 6 2, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
    Neurochem Int 53:137-47. 2008
    Although a large number of signalling cascades are known to be activated downstream of NCAM, only little is known regarding the hierarchical relationship between the involved molecules in the individual cascades and the level of cross ..
  61. ncbi Macrochimerism of donor type CD56+ CD3+ T cells in donor specific transfusion via portal vein following living related donor liver transplantation
    Yoshinobu Sato
    First Department of Surgery, Niigata University School of Medicine, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Hepatogastroenterology 50:2161-5. 2003
    ..She did not suffer from acute cellular rejection and was discharged on day 30 the after operation. CD56+ CD3+ T cells in the liver increased notably from 20% to 50% after transplantation...
  62. ncbi NCAM in the organ of Corti of the developing mouse
    D S Whitlon
    Department of Neurology, University of Wisconsin, Madison
    J Neurocytol 19:970-7. 1990
    During development in the cochlea, NCAM is present on all neuronal systems--radial fibres, inner spiral bundle, inner pillar bundle (described by Sobkowicz & Emmerling, 1989), and outer spiral fibres...
  63. ncbi Distribution of the neural cell adhesion molecule (NCAM) during pre- and postnatal development of mouse incisors
    N Obara
    Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Anat Embryol (Berl) 195:193-202. 1997
    Developmental changes in the distribution of the neural cell adhesion molecule (NCAM) were investigated in mouse incisors by means of the indirect immunofluorescence method...
  64. ncbi An immunohistochemical study of CD4, CD8, TIA-1 and CD56 subsets in inflammatory skin disease
    Jeff D Harvell
    Department of Surgical Pathology, Stanford University Medical Center, Stanford, CA, USA
    J Cutan Pathol 30:108-13. 2003
    Antibodies to CD4, CD8, TIA-1, and CD56 are available which perform well in formalin-fixed and paraffin-embedded tissue...
  65. ncbi CD56 expression in ovarian granulosa cell tumors, and its diagnostic utility and pitfalls
    Yoshihiro Ohishi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Gynecol Oncol 107:30-8. 2007
    The purpose of this study is to investigate CD56 staining in ovarian granulosa cell tumor and its morphological mimics in order to determine the value of CD56 staining in a diagnostic setting.
  66. ncbi Expression of NCAM and its polysialylated isoforms during mdx mouse muscle regeneration and in vitro myogenesis
    C Dubois
    Laboratoire de Biologie Cellulaire, Faculte de Medecine Saint Antoine, Paris, France
    Neuromuscul Disord 4:171-82. 1994
    ..of the muscular regenerative process which occurs in mdx mice, the expression of neural cell adhesion molecule (NCAM) isoforms and their polysialylated (PSA) derivatives were studied during the postnatal development of normal and ..
  67. ncbi Detection of micrometastasis of neuroblastoma to bone marrow and tumor dissemination to hematopoietic autografts using flow cytometry and reverse transcriptase-polymerase chain reaction
    Kam Sze Tsang
    Division of Hematology Blood and Marrow Transplantation, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, China
    Cancer 97:2887-97. 2003
    ..The identification of neuroblastoma metastases to bone marrow (BM) is requisite in staging disease for risk-adopted therapy. However, micrometastases were not elucidated fully...
  68. pmc Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1
    Venkata Lokesh Battula
    University of Tubingen, Department of Internal Medicine II, Medical, Otfried Muller Str 10, 72076, Tubingen, Germany
    Haematologica 94:173-84. 2009
    ..with superior selectivity for mesenchymal stem cells, including the monoclonal antibodies W8B2 against human mesenchymal stem cell antigen-1 (MSCA-1) and 39D5 against a CD56 epitope, which is not expressed on natural killer cells.
  69. ncbi [The immunophenotypic analysis of CD7+ and (or) CD56+ acute myeloid leukemic stem cells and its applications in minimal residual disease detection]
    Hui Cao
    People s Hospital of Peking University, Beijing 100044, China
    Zhonghua Xue Ye Xue Za Zhi 29:23-8. 2008
    To explore the immunophenotypic characteristics of CD7 and/or CD56 positive acute myeloid leukemic stem cells, and the relationship between minimal residual disease (MRD) and the leukemic stem cells (LSC).
  70. ncbi Temporal changes in NCAM immunoreactivity during taste cell differentiation and cell lineage relationships in taste buds
    Hirohito Miura
    National Food Research Institute, 2 1 12 Kannondai, Ibaraki 305 8642, Japan
    Chem Senses 30:367-75. 2005
    Neural cell adhesion molecule (NCAM) is a type III cell marker in the taste buds...
  71. ncbi Extracellular adenosine triphosphate affects neural cell adhesion molecule (NCAM)-mediated cell adhesion and neurite outgrowth
    G Skladchikova
    Protein Laboratory, Institute of Molecular Pathology, University of Copenhagen, Copenhagen, Denmark
    J Neurosci Res 57:207-18. 1999
    The neural cell adhesion molecule (NCAM) plays an important role in synaptic plasticity in embryonic and adult brain. Recently, it has been demonstrated that NCAM is capable of binding and hydrolyzing extracellular ATP...
  72. ncbi Overexpression of neural cell adhesion molecule (NCAM) antigens on intestinal smooth muscles in hypoganglionosis: is hypoganglionosis a disorder of the neuromuscular junction?
    Hiroyuki Kobayashi
    Department of Pediatric Surgery, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, 113 8421 Tokyo, Japan
    Pediatr Surg Int 19:190-3. 2003
    ..The purpose of the present study was to investigate the neuromuscular junction (NMJ) in small- and large-intestine biopsy specimens from patients with HP...
  73. ncbi Expression of cell adhesion molecules and tumour infiltrating leucocytes in conjunctival melanoma
    Gerasimos Anastassiou
    Department of Ophthalmology, University of Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Melanoma Res 14:381-5. 2004
    ..We investigated the expression of cell adhesion molecules and the grade of tumour infiltration with lymphocytes and macrophages as important members for the communication between tumour cells and the immune system...
  74. ncbi 3alpha,5alpha-Tetrahydroprogesterone (allopregnanolone) and gamma-aminobutyric acid: autocrine/paracrine interactions in the control of neonatal PSA-NCAM+ progenitor proliferation
    Nathalie Gago
    INSERM U 488, Bicetre, France
    J Neurosci Res 78:770-83. 2004
    ..neural progenitors are cells that express the polysialylated form of the neural cell adhesion molecule (PSA-NCAM). One of these progenitors is the early PSA-NCAM+ progenitor (ePSA-NCAM+ progenitor; Gago et al...
  75. ncbi Oxytocin neuron activation in NCAM-deficient mice: anatomical and functional consequences
    D T Theodosis
    Laboratory of Morphofunctional Neurobiology, INSERM U 378, University Victor Segalen, 733770 Bordeaux, France
    Eur J Neurosci 20:3270-80. 2004
    ..We identified polysialic acid on the neural cell adhesion molecule (NCAM) as an important mediator of such plasticity...
  76. ncbi Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia
    J R Novotny
    Department of Haematology, University Hospital of Essen, Essen, Germany
    Eur J Haematol 76:299-308. 2006
    ..The possible contribution of surface molecules to the development of leukostasis syndrome in hyperleukocytic acute myeloid leukaemia (AML) was assessed by routine immunophenotyping and grading of the probability of clinical leukostasis...
  77. ncbi [Immunophenotype characteristics and prognosis of acute leukemia patients with cross expressing lymphoid and myeloid lineage associated antigens]
    Neng Gang Jiang
    Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1405-9. 2010
    ..The cross-expressed antigens analyzed for AML included CD2, CD7, CD19, CD56 and other co-expressed lymphoid antigens...
  78. ncbi CD56 expression is an indicator of poor clinical outcome in patients with acute promyelocytic leukemia treated with simultaneous all-trans-retinoic acid and chemotherapy
    F Ferrara
    Divisione di Ematologia, Sezione TERE, Servizio di Immunoematologia, Ospedale Cardarelli, Naples, Italy
    J Clin Oncol 18:1295-300. 2000
    Preliminary reports suggest that leukemic cell expression of CD56, a neural cell adhesion molecule, is associated with adverse clinical outcome in either acute myeloid leukemia with t(8;21) or acute promyelocytic leukemia (APL)...
  79. ncbi Thyroid hormone down-regulates neural cell adhesion molecule expression and affects attachment of gonocytes in Sertoli cell-gonocyte cocultures
    A L Laslett
    Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Endocrinology 141:1633-41. 2000
    ..Specifically, down-regulation of neural cell adhesion molecule (NCAM)-based intercellular adhesion during postnatal maturation is likely to be important for appropriate differentiation ..
  80. ncbi NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status
    Y H Ko
    Department of Pathology, Sungkyunkwan University, Samsung Medical Center, Seoul, Korea
    Histopathology 44:480-9. 2004
    To analyse the clinicopathological findings of extranasal CD56+ cytotoxic T- or NK-cell lymphomas in different organs and to compare Epstein-Barr virus (EBV)+ and EBV- lymphoma of non-blastoid cytomorphology.
  81. ncbi Acute activation of CB1 cannabinoid receptors transiently decreases PSA-NCAM expression in the dentate gyrus of the rat hippocampus
    Marzena Mackowiak
    Laboratory of Pharmacology and Brain Biostructure, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, 12 Smetna Street, Poland
    Brain Res 1148:43-52. 2007
    Recent evidence indicates that the polysialylated neural cell adhesion molecule (PSA-NCAM) is involved in hippocampal plasticity...
  82. ncbi [CD56 and CD11b antigen expressions in patients with acute monocytic leukemia and the clinical implications]
    Na Xu
    Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 50515, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:1605-8. 2009
    To investigate the expressions of cell surface differentiation antigen CD56 and CD11b antigen in acute monocytic leukemic (AML-M(5)) cells and their clinical significance.
  83. doi Neural cell adhesion molecule is a cardioprotective factor up-regulated by metabolic stress
    Kazuya Nagao
    Department of Cardiovascular Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Mol Cell Cardiol 48:1157-68. 2010
    ..One of the genes identified was that for neural cell adhesion molecule (NCAM, CD56), a major regulator of development, cell survival, migration, and neurite outgrowth in the nervous system...
  84. ncbi Expression of the neural cell adhesion molecule (NCAM) during second- and third-molar development in the mouse
    N Obara
    Department of Oral Anatomy, School of Dentistry, Higashi Nippon Gakuen University, Hokkaido, Japan
    Anat Embryol (Berl) 188:13-20. 1993
    Distribution of the neural cell adhesion molecule (NCAM) during the development of the mandibular second- and third-molars of the mouse was studied by indirect immunofluorescence techniques...
  85. ncbi Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice
    O Stork
    Department of Neurobiology, Swiss Federal Institute of Technology, Honggerberg, CH 8093 Zurich, Switzerland
    J Neurobiol 40:343-55. 1999
    Mice deficient in the neural cell adhesion molecule (NCAM) show behavioral abnormalities as adults, including altered exploratory behavior, deficits in spatial learning, and increased intermale aggression...
  86. ncbi Association between intracranial plasmacytoma and multiple myeloma: clinicopathological outcome study
    T H Schwartz
    Department of Neurosurgery, Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 East 68th Street, New York, NY 10021, USA
    Neurosurgery 49:1039-44; discussion 1044-5. 2001
    ..Attention has recently been focused on the role of the cell adhesion molecules CD56 and CD31 in the pathogenesis of myeloma...
  87. ncbi Characterization of a novel NCAM ligand with a stimulatory effect on neurite outgrowth identified by screening a combinatorial peptide library
    Lars C B Rønn
    Protein Laboratory, Institute of Molecular Pathology, Panum Institute 6 2, Blegdamsvej 3, DK 2200, Copenhagen N, Denmark
    Eur J Neurosci 16:1720-30. 2002
    The neural cell adhesion molecule, NCAM, plays a key role in neural development and plasticity mediating cell adhesion and signal transduction...
  88. ncbi Non-B, non-T neoplasms with lymphoblast morphology: further clarification and classification
    Kennosuke Karube
    Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7 45 1, Jonan ku, Fukuoka 814 0180, Japan
    Am J Surg Pathol 27:1366-74. 2003
    ..was further divided based on immunohistochemistry into: 1) CD7+ stem cell lymphoma (CD7+SCL) [CD4-, CD7+, CD33+/-, CD56-], 2) blastic natural killer cell lymphoma (B-NKL) [CD4-, CD7+/-, CD33-, CD56+, CD123-], 3) myeloid/NK precursor ..
  89. ncbi CD56+ hematological neoplasms presenting in the skin: a retrospective analysis of 23 new cases and 130 cases from the literature
    M W Bekkenk
    Department of Dermatology, Leiden University Medical Center, Leiden
    Ann Oncol 15:1097-108. 2004
    The aim of this study was to define prognostic parameters and guidelines for diagnosis and treatment for CD56+ hematological neoplasms with first presentation in the skin.
  90. ncbi PSA-NCAM in mammalian structural plasticity and neurogenesis
    Luca Bonfanti
    Department of Veterinary Morphophysiology, University of Turin, Via Leonardo da Vinci 44, 10095 Grugliasco, Italy
    Prog Neurobiol 80:129-64. 2006
    ..of alpha2-8-N acetylneuraminic acid whose major carrier in vertebrates is the neural cell adhesion molecule (NCAM). PSA serves as a potent negative regulator of cell interactions via its unusual biophysical properties...
  91. doi Estrogens regulate posttranslational modification of neural cell adhesion molecule during the estrogen-induced gonadotropin surge
    Orkun Tan
    Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York 10016, USA
    Endocrinology 150:2783-90. 2009
    ..Because in situ enzymatic desialization of hypothalamic polysialylated (PSA) neural cell adhesion molecule (NCAM) blocked EISP, we examined the presence and amount of NCAM isotopes, PSA-NCAM, and sialylation enzymes in ..
  92. ncbi Nodular lesions of the liver in multiple myeloma: a role for cytoadhesion molecules?
    P Musto
    Department of Hematology, IRCCS Casa Sollievo della Sofferenza Hospital, S Giovanni Rotondo, Italy
    Tumori 78:300-4. 1992
    ..In particular, the expression on neoplastic plasma cells of the cytoadhesion molecules CD56 and CD11a, which are involved in the cellular process of recirculation and homing, suggests a possible role for ..
  93. ncbi Expression of GPI-anchored complement regulatory proteins CD55 and CD59 differentiates two subpopulations of human CD56+ CD3- lymphocytes (NK cells)
    K R Solomon
    Laboratory of Infectious Diseases, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Cell Immunol 165:294-301. 1995
    ..Using three-color cytofluorographic analysis with antibodies recognizing CD56, CD3, and CD59 or CD55 we determined that CD56+CD3- lymphocytes (NK cells) expressed both CD55 and CD59 but at ..
  94. ncbi Human uterine natural killer cells
    A King
    Department of Pathology, University of Cambridge, UK
    Nat Immun 15:41-52. 1996
    The human uterine mucosa is infiltrated by large numbers of CD56+ natural killer (NK) cells which are particularly abundant around the time of implantation and during early pregnancy...
  95. ncbi Expression of major histocompatibility complex antigens and induction of human T-lymphocyte proliferation by astrocytes and macrophages from porcine fetal brain
    T Brevig
    Department of Clinical Immunology, Odense University Hospital, Odense C, DK 5000, Denmark
    Exp Neurol 159:474-83. 1999
    ..nonautofluorescent cells stained positive for the astrocyte marker glial fibrillary acidic protein and CD56 (NCAM isoform)...
  96. ncbi Expansion of cytotoxic CD3+ CD56+ cells from peripheral blood progenitor cells of patients undergoing autologous hematopoietic cell transplantation
    J C Alvarnas
    Department of Medicine, Stanford University Medical Center, California, USA
    Biol Blood Marrow Transplant 7:216-22. 2001
    ..We have characterized the ex vivo expansion, up to 1000-fold, of CD3+ CD56+ lymphocytes from the peripheral blood lymphocytes (PBL) of healthy donors...
  97. ncbi Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion
    T Hayashi
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikata machi, 700 8558, Okayama, Japan
    Brain Res 907:130-3. 2001
    The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth...
  98. ncbi Immunolocalization of FAS and FAS ligand in inflammatory myopathies
    J L De Bleecker
    Ghent University Hospital, Department of Neurology, Belgium
    Acta Neuropathol 101:572-8. 2001
    ..Fas signal occurred on the sarcolemma, and to a lesser extent in the sarcoplasm of neural cell adhesion molecule (NCAM)-positive or developmental myosin heavy chain-positive regenerating muscle fibers and of injured fibers with ..
  99. ncbi Prediction of malignant behavior of pheochromocytomas and paragangliomas using immunohistochemical techniques
    Nobue Kumaki
    Department of Pathology, Tokai University, School of Medicine, Isehara, Kanagawa, Japan
    Endocr Pathol 13:149-56. 2002
    ..The markers used in this study were chromogranin A, synaptophysin, NCAM (CD56), SNAP25, neuron-specific enolase, S-100 protein, and MIB-1...
  100. ncbi Xenopus X-box binding protein 1, a leucine zipper transcription factor, is involved in the BMP signaling pathway
    Hui Zhao
    Department of Zoophysiology, University of Essen, Universitatsstrasse 5, D 45117 Essen, Germany
    Dev Biol 257:278-91. 2003
    ..fusing the DNA-binding domain to the even-skipped repressor domain leads to upregulation of the neural markers NCAM and nrp-1 in animal cap assay...
  101. ncbi Apoptosis of extravillous trophoblast cells limits the trophoblast invasion in uterine but not in tubal pregnancy during first trimester
    U von Rango
    Department of Anatomy and Reproductive Biology, RWTH University of Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Placenta 24:929-40. 2003
    ..labelling, maternal leukocyte subtypes were co-localized to apoptotic cells and in this context, the number of CD56(+)NK cells was analyzed. Our data show that apoptosis is confined to the decidua basalis...

Research Grants103 found, 100 shown here

  1. Natural Killer Cell Receptor Diversity and CMV in Hematopoietic Cell Transplantat
    STEVEN AARON PERGAM; Fiscal Year: 2013
    ..In addition, our data suggests that fewer cytotoxic CD56[unreadable]"/KIR* natural killer cells in the post-HCT period increase the risk of CMV reactivation...
  2. Pediatric Immune Correlates of Early Anti-HIV Therapy
    Luis J Montaner; Fiscal Year: 2010
    ..and development of antiviral effector mechanisms (development and retention of plasmacytoid CD123+ dendritic cell, CD56+ Natural Killer cells and CD4+/CD8+ proliferative antiviral responses) that will be positively associated with a ..
  3. BIOCHEMICAL CONSEQUENCES OF CELL-CELL CONTACT
    Urs Rutishauser; Fiscal Year: 1990
    ..of membranes can be blocked by the addition of Fab fragments directed against the neural cell adhesion molecules (NCAM)...
  4. MOLECULAR DETERMINANTS OF AXON GROWTH
    CARL LAGENAUR; Fiscal Year: 1999
    ..and neurite outgrowth that is distinct from the pattern observed with other cell adhesion molecules, such as L1 or NCAM. Cerebellar granule cells growing on P84-coated substrates extend neurites with large growth cones and very active ..
  5. Force Probe Investigations of NCAM Adhesion
    Deborah Leckband; Fiscal Year: 2004
    ..structure, the fundamental physical mechanisms of homophilic adhesion between neural cell adhesion molecules (NCAM) and the regulation of NCAM adhesion by post-translational modification...
  6. Immunophenotyping and Lymphocyte Effector Functions in Sarcoidosis
    Laura L Koth; Fiscal Year: 2010
    ..of iNTK cells with lower frequencies of the CD4-CD8- subset compared to controls, and 3) had higher percentages of CD56+ iNKT cells which correlated with the degree of airway obstruction...
  7. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
    ..both on the initial DBS), a second whole blood specimen is assessed by flow cytometry (CD3, CD4, CD8, CD19, CD56, CD45 and CD45RO);low counts warrant immediate referral and assessment at the Immune Deficiency Clinic at CHW...
  8. NK CELL ADCC AND CD4+ CELL APOPTOSIS IN HIV+ TISSUES
    Gail Skowron; Fiscal Year: 2003
    ..and the expression of p24, gp120 and gp41), the presence of NK cells in lymphoid tissues (measured as CD16+, CD56+, CD57+ and/or CD94+ cells), the cytolytic potential of CD16+ and CD8+ cells (measured by expression of granzyme B ..
  9. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..The cadherin Neural Cell Adhesion Molecule (NCAM) is key in leukocyte adhesion to endothelial cells...
  10. Rene Hen; Fiscal Year: 2016
    ..multipotent progenitor cells (Nestin, Pax6, GFAP), neuronal progenitors cells and neuroblasts (TUC-4, TUJ-1, PSA-NCAM), or immature glia (Vimentin) will be used to establish the phenotype of the dividing cells...
  11. BIOSYNTHESIS OF MEMBRANE PROTEIN GLYCOLIPID ANCHORS
    Anant K Menon; Fiscal Year: 2010
    ..GPI)-anchored proteins (such as the folate receptor, prion protein, and the neural cell adhesion molecule (NCAM)) is critical for normal cell growth, and perturbed in human cancers as well as a number of genetic diseases...
  12. Mechanism of the Protein Specific Polysialylation of NCAM
    JOSEPH LOUIS ZAPATER; Fiscal Year: 2013
    ..the polysialylation of a limited number of substrate glycoproteins, with the neural cell adhesion molecule (NCAM) being the primary substrate...
  13. Mechanisms for depleting tumor immunity in AIDS
    CHARLES DAVID PAUZA; Fiscal Year: 2012
    ..2008) that the subset of [unreadable][unreadable] T cells expressing cell surface CD56 is potently cytotoxic against squamous cell carcinoma cell lines and resists TNF[unreadable] or Fas-mediated ..
  14. ENRIQUE J RODRIGUEZ-BOULAN; Fiscal Year: 2016
    ..g. the coxsackie adenovirus receptor (CAR) and neural adhesion molecule (NCAM))...
  15. Karen J Colley; Fiscal Year: 2015
    ..Polysialic acid (polySia) is best known for its ability to block neural cell adhesion molecule (NCAM)-dependent cell adhesion and signaling, and for its roles in cell migration, axon guidance, synaptic plasticity, an ..
  16. CD8 T Cells in Rheumatoid Arthritis
    Cornelia M Weyand; Fiscal Year: 2010
    ..This proposal is designed to explore the mechanisms through which CD8+CD28~CD56+ T suppressor cells inhibit rheumatoid synovitis and how they can be developed into a novel adoptive immunotherapy ..
  17. MOLECULAR DISSECTION OF TUMOR INVASION
    SCOTT A GOODE; Fiscal Year: 2010
    ..The basolateral junction is comprised of Immunoglobulin superfamily members Fasciclin2 (human NCAM) and Neuroglian (human L1), and scaffolding molecules Discslarge (hDIg) and Lethal Giant larvae (hLgl)...
  18. Protein-Specific Polysialylation
    Karen J Colley; Fiscal Year: 2010
    ..acid (PSA) is a developmental regulated, anti-adhesive glycan that is added to the neural cell adhesion molecule (NCAM), the most abundant of five mammalian polysialylated proteins...
  19. TISSUE AND SERUM INDICATORS OF LUNG CANCER RECURRENCE
    David Harpole; Fiscal Year: 2000
    ..factor viii), proliferation markers (K1-67) and markers of cellular differentiation (Blood group A, H/LeV/LeB, NCAM, CD44)...
  20. Mapping Genes for comorbidity of SUDs and Depression
    Bao zhu Yang; Fiscal Year: 2012
    ..Identifying genetic and environmental causes of this comorbidity can have a significant impact on the design of effective treatments and prevention strategies, and fulfills NIDA's mission. ..
  21. CDP/CUT AND MYELOID DIFFERENTIATION
    Nancy Berliner; Fiscal Year: 2001
    ..expressed in other tissues, and has been implicated in regulating expression of widely disparate genes such as NCAM, g-globin, and c-myc...
  22. ADHESION MOLECULES AND EPIDERMAL STRATIFICATION
    ROBERT LAVKER; Fiscal Year: 2001
    ..Using chimeric constructs, i.e., substituting the NCAM extracellular domain, the investigators will establish the relevance of the specificity of the interaction...
  23. Mechanisms of Neuromuscular Repair by Schwann Cells
    Young Jin Son; Fiscal Year: 2006
    ..In Aim 3, we will test the hypothesis that NCAM and N-cadherin, the two cell adhesion molecules (CAMs) upregulated in activated tSCs, elicit sprouting...
  24. AXON GUIDANCE IN THE SPINAL CORD
    Zaven Kaprielian; Fiscal Year: 2007
    ..guidance systems (Robo-Slit, Npn-Sema, Wnt-Fz, Shh signaling) and contact-dependent guidance signals (NrCAM, PSA-NCAM, L1, Eph/ephrins) regulate the pathfinding of post-crossing d!1 and d!2 axons, even in the absence of FP contact...
  25. Hippocampal atrophy in major depression
    Craig Stockmeier; Fiscal Year: 2007
    ..factor (BDNF), growth associated protein-43 (GAP-43) and polysialylated-nerve cell adhesion molecule (PSA-NCAM)] throughout the hippocampus in MDD...
  26. IMMUNE MONITOR FOR COG TRIAL OF ANTI-GD2 IN NEUROBLASTOMA
    Alice Yu; Fiscal Year: 2009
    ..In addition to ADCC, CD56+ lymphocytes which consist of NK (CD3-) and NK-T (CD3+) cells are believed to be major players in immune ..
  27. CYTOSKELETAL DISORGANIZATION ALZHEIMER'S DISEASE
    Ann McKee; Fiscal Year: 1993
    ..be examined using markers associated with growth cones, including actin, GAP 43, and neural cell adhesion molecule (NCAM)...
  28. Activation of Innate Immunity Effector Cells
    ARTHUR BUCHBERG; Fiscal Year: 2007
    ..We have defined that immature CD161+CD56 - NK cells have highest proliferative potential in response to interleukin (IL)-4, can not mediate granule ..
  29. Perinatal Neurodegeneration and Schizophrenia
    Kenneth Johnson; Fiscal Year: 2004
    ..Premature loss of striatal PSA-NCAM at PN 15 suggested the possibility that PCP treatment results in altered striatal function...
  30. CORTICAL CONTROL OF STRIATAL GENE EXPRESSION
    Marie Francoise Chesselet; Fiscal Year: 1999
    ..growth factor (bFGF), neurotrophins (BDNF, NT3), and the highly polysialilated neural cell adhesion molecule (PSA-NCAM)...
  31. MECHANISM OF TOXICANT INDUCED INJURY IN NEONATAL TESTES
    Joanne Orth; Fiscal Year: 2002
    ..4] To determine whether phthalates impair Sertoli cell and/or gonocyte development by interfering with normal NCAM-and/or c-kit-based cell-cell interactions...
  32. CONTACT DEPENDENT ENDOTHELIAL ACTIVATION BY NK CELLS
    Jeffrey Bender; Fiscal Year: 2003
    ..We have previously demonstrated that, in a beta2 integrin-ICAM adhesion-dependent fashion, human CD56+, CD3- NK cells efficiently induce activation of EC MHC class II genes...
  33. GUIDANCE OF NEURONAL MIGRATION IN EMBRYONIC DEVELOPMENT
    PHILIP COPENHAVER; Fiscal Year: 2005
    ..Like its vertebrate counterpart NCAM, MFas Il is a member of the immunoglobulin related adhesion receptor family...
  34. CELL RECOGNITION DURING NEURONAL DEVELOPMENT
    COREY GOODMAN; Fiscal Year: 1999
    ..contact-mediated attractive guidance molecule of the immunoglobulin superfamily and is closely related to mammalian NCAM. Semaphorin II is a chemorepellent/inhibitor and is closely related to mammalian semaphorin III/collapsin and other ..
  35. CELL-CELL ADHESION MOLECULES IN DEVELOPMENT
    Urs Rutishauser; Fiscal Year: 1993
    ..The major focus of this work is the neural cell adhesion molecule (NCAM), which is a broadly distributed cell surface protein believed to influence a wide variety of cell interactions...
  36. CHARACTERIZATION OF HSPGS IN NEURAL DEVELOPMENT
    GREGORY COLE; Fiscal Year: 1991
    The neural cell adhesion molecule NCAM plays a critical role in mediating cell-cell interactions in the developing nervous system...
  37. Glycoproteins in Neural Cells and Cancer
    Minoru Fukuda; Fiscal Year: 2010
    The primary objective of this proposal is to determine the roles of polysialic acid, NCAM, and HNK-1 glycan in neural development and cancer. In the past few years, we have made critical progress in this field...
  38. BIOLOGICAL RHYTHMS, PLASTICITY AND BEHAVIOR
    John Glass; Fiscal Year: 2000
    ..The polysialylated NCAM (PSA-NCAM) is a cell surface component which plays key roles in neurogenesis and is retained in regions of the ..
  39. PROTEIN SYNTHESIS MEMORY AND PEDIATRIC BRAIN INJURY
    Larry Jenkins; Fiscal Year: 2002
    ..The neural cell adhesion molecule (NCAM) has been associated with hippocampal synaptic plasticity both during development in the immature and learning in ..
  40. Therapeutic Cloning in Parkinsonian Mice
    Lorenz Studer; Fiscal Year: 2003
    ..Fluorescence activated cell sorting (FACS) for the neural-specific surface molecule PSA-NCAM will be used to eliminate-any remaining undifferentiated cell populations...
  41. STUDIES OF SYNAPSE FORMATION
    LYNN LANDMESSER; Fiscal Year: 2007
    ..the cellular and molecular mechanisms underlying the recently identified roles of the different isoforms of NCAM in bringing about the structural and functional maturation of the neuromuscular junction required for normal motor ..
  42. Development Therapy for Metastatic Colorectal Cancer
    Janet Houghton; Fiscal Year: 2007
    ..to disease progression, response, and how changes in Fas expression correlate with elevated expression in CD15+ and CD56+ cells, as well as toxicity and IFN-gamma pharmacokinetics, will be determined...
  43. CELL ADHESION IN DEVELOPMENT OF THE EYE
    Urs Rutishauser; Fiscal Year: 1999
    ..The major focus of this work is the neural cell adhesion molecule (NCAM), which is a broadly distributed cell surface protein whose binding properties and unusual polysialic acid (PSA) ..
  44. TROPHIC DETERMINANTS OF OLIGODENDROCYTE DEVELOPMENT
    ANTHONY GARD; Fiscal Year: 1999
    ..specific cell adhesion molecules in the immunoglobulin superfamily, the myelin- associated glycoprotein (MAG) and NCAM, which also promote growth by augmenting myelin-like membrano-genesis...
  45. DEVELOPMENT AND TROPHIC NEURAL INTERACTIONS
    LYNN LANDMESSER; Fiscal Year: 2009
    ..from stages 20-23 was recently shown to alter the expression of specific adhesion/guidance molecules such as PSA-NCAM, EphA4, and CRYPD,to cause alterations in axon fasciculation, and to produce motor axon pathfinding errors...
  46. Sex specific adaptations to muscle unloading
    Michael R Deschenes; Fiscal Year: 2010
    ..efficacy, neuromuscular junction morphology, myofiber profiles (fiber type and size) and the expression of NCAM and Synaptotagmin, two important regulatory molecules of synaptic function and structure...
  47. CELL ADHESION AND CARDIOGENESIS
    Michiko Watanabe; Fiscal Year: 1992
    Research on the neural cell adhesion molecule (NCAM) has advanced the understanding of basic events in neural and skeletal muscle development...
  48. NEUROTROPHIN LIKE SMALL MOLECULE FOR ALZHEIMERS DISEASE
    ALAN O CONNELL; Fiscal Year: 1999
    ..Like NGF, ABS 205 enhances expression of the neural cell adhesion molecule (NCAM) and causes its posttranslational modification (polysialylation)...
  49. Neurocognitive Assessment Meter For Psychiatric Drugs
    Alan Gevins; Fiscal Year: 2003
    ..The NeuroCognitive Assessment Meter (NCAM) will combine neurophysiological and behavioral measures to exploit the complementary forms of information that ..
  50. CELL-CELL ADHESION IN DEVELOPMENT
    Urs Rutishauser; Fiscal Year: 2003
    ..The major focus of this work is the neural cell adhesion molecule (NCAM), which is a broadly distributed cell surface protein whose binding functions and unusual polysialic acid (PSA) ..
  51. NEURONAL MIGRATION IN THE DEVELOPING BRAIN
    Huaiyu Hu; Fiscal Year: 2003
    ..to the olfactory bulb in "chains," a process requiring the polysialic acid moiety of neural cell adhesion molecule (NCAM). The long-term goal is to elucidate the molecular mechanisms that regulate neuronal migration...
  52. Anti-HIV-1 Effect of TALL-104 Cells
    Jihed Chehimi; Fiscal Year: 2005
    ..approach based on antiviral activity of a MHC non-restricted human cytotoxic T cell line, TALL-104 (CD3/TCR+ CD8+ CD56+ CD16-)...
  53. Jianhua Yu; Fiscal Year: 2016
    ..and molecular level, including some recent intriguing data that may define the lymph node as a site of human CD56 (bright) NK cell development...
  54. SRC KINASES IN THE DEVELOPING NERVOUS SYSTEM
    Patricia Maness; Fiscal Year: 2004
    Cell adhesion molecules of the Ig family (L1 ,NCAM) play important roles in axonal growth throughout the nervous system, and have potentially novel functions in axon targeting, dendrite development, and synapse formation...
  55. Recognition Molecules in Cortical Development
    Patricia Maness; Fiscal Year: 2008
    ..This investigation can reveal new molecular determinants and novel mechanisms governing cortical area development and provide insight into the pathology associated with mental retardation. ..
  56. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
    ..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
  57. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
    ..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
  58. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  59. A Rapid Immunoassay for Detection of Yersinia Pathogens
    John Glass; Fiscal Year: 2002
    ..Furthermore, this prototype assay will be reduced to a production model, validated for regulatory approval, and finalized for manufacture through a joint venture partner. ..
  60. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  61. Development of a T cell specific multiple sclerosis drug
    Arthur Vandenbark; Fiscal Year: 2005
    ..The proposed studies will address key milestones to establish clinical safety of VG1000 needed for subsequent proof-of-principle trials to evaluate inhibition of MOG-specific T cell responses and clinical efficacy. ..
  62. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  63. VIRAL AND IMMUNE RESPONSE TO THERAPY FOR HIV IN THE GALT
    Andrew Talal; Fiscal Year: 2003
    ..This project amy provide important insights into the amount of time needed to treat HIV- infected individuals and may provide novel approaches by which to monitor therapeutic responses in these individuals. ..
  64. Facilitating Cells for Fetal Hematopoietic Transplant
    Laurence Shields; Fiscal Year: 2005
    ..Future directions will be towards the use of this model to explore the role and function of developmentally regulated adhesion molecules and their receptors as they relate to fetal hematopoietic transplantation. ..
  65. GI Inflammation: Novel G-Protein Coupled PMN Responses
    David Jaye; Fiscal Year: 2006
    ..He will also have access to a wealth of seminars in the scientific community at Emory University and formal didactic training within the Graduate School. ..
  66. Pilot Intervention for PTSD, Nonadherence and HIV Risk
    Douglas Delahanty; Fiscal Year: 2007
    ....
  67. VEGF and bone remodeling in skeletal metastases
    Evan Keller; Fiscal Year: 2005
    ..In this aim, we will test which VEGF isoform contributes to CaP cells' osteoblastic activity. We will also evaluate if VEGF induces this activity through MAPK. ..
  68. Chromatin Pathology in Cerebral Cortex of Schizophrenics
    Schahram Akbarian; Fiscal Year: 2006
    ..Finally, the proposed studies will provide the framework for future proposals designed to map histone modification patterns across entire chromosomes in human brain, including alterations in major psychiatric disease. ..
  69. Approaches to the Genetics of Substance Dependence
    Joel Gelernter; Fiscal Year: 2007
    ..This proposal would permit the PI to make a major investment in mentorship, and allow a broadening of his research program in substance dependence. [unreadable] [unreadable] [unreadable] [unreadable]..
  70. Mast Cell Role in Masseter Muscle Repair
    JOYCE MORRIS WIMAN; Fiscal Year: 2005
    ....
  71. HIV and the Mucosal Immune System:New Vaccine Strategies
    Karol Sestak; Fiscal Year: 2006
    ..Moreover, this proposed study might identify important correlates of protective immune responses that will be useful in designing effective therapeutic strategies. ..
  72. Human Monoclonal Antibodies from Immunized Patient Lymphocytes
    Philip Livingston; Fiscal Year: 2008
    ..Establishment of new metastasis would no longer be possible so aggressive local therapies including surgery or radiation therapy might result in long term control of even metastatic cancers. [unreadable] [unreadable] [unreadable]..
  73. Low-level toxicant perturbation of neural cell function
    Mark D Noble; Fiscal Year: 2010
    ....
  74. LASER CAPTURE MICROSCOPE
    Carol Petito; Fiscal Year: 2001
    ..Consequently, we request a camera and a workstation for the double headed microscope. This will be exclusively be utilized by Users of the LCM facility. ..
  75. Microarrays & Proteomics in MZ Twins Discordant for CFS
    Patrick Sullivan; Fiscal Year: 2006
    ..If successful, this work could lead to profound changes in the understanding of CFS and resolution of some attendant controversies. ..
  76. Major Depression: Stage 1 Genomewide Association in Population-Based Samples
    Patrick Sullivan; Fiscal Year: 2007
    ..This is arguably the best and most comprehensive sample collection for MDD in the world. [unreadable] [unreadable] [unreadable]..
  77. INTERACTION BETWEEN NICOTINE AND STRESS
    BURT SHARP; Fiscal Year: 2009
    ..Together, the studies in this proposal will clarify the effects of chronic nicotine SA on HPA responsiveness to stressors and on underlying adaptive changes in the brainstem HPA axis. ..
  78. Endogenous MHC class II antigen processing via autophagy
    CHRISTIAN MUNZ; Fiscal Year: 2008
    ..These studies will allow us to understand better how tumors can be detected by the immune system and how we can enhance immune responses to cancer. [unreadable] [unreadable] [unreadable]..
  79. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  80. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2009
    ....
  81. GENETICS OF COCAINE INDUCED PSYCHOSIS
    Joel Gelernter; Fiscal Year: 2003
    ..This program of research will improve our understanding of the genetics underlying human brain responses to chronic cocaine exposure, thus leading to better diagnosis and treatments for cocaine dependence and other addictive disorders. ..
  82. GENETIC & ENVIRONMENT DETERMINANTS OF SMOKING CESSATION
    Patrick Sullivan; Fiscal Year: 2006
    ....
  83. Transmission genetics of mammalian mitochondrial DNA
    Eric Shoubridge; Fiscal Year: 2008
    ..abstract_text> ..
  84. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur A Vandenbark; Fiscal Year: 2010
    ..abstract_text> ..
  85. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  86. Pilot trial with a tetravalent conjugate vaccine against small cell lung cancer
    Philip Livingston; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  87. OPIATE RECEPTOR-MEDIATED EFFECTS OF STRESS ON IMMUNITY
    BURT SHARP; Fiscal Year: 2008
    ..In summary, by focusing on the attenuation of TCR signaling and the downregulation of CXCR4, these studies will provide a mechanistic basis for understanding the opposing effects of DORS. ..
  88. Innate-like hepatic CD1d-reative NKT cells:Liver Disease
    Mark Exley; Fiscal Year: 2008
    ..I. on acute HCV infection in chimpanzees, as well as on liver immunology and on 'NKT' cells in general. ..
  89. Innate Immune Responses During Therapy for Chronic HCV
    HUGO ROSEN; Fiscal Year: 2009
    ..abstract_text> ..
  90. SPHINGOGLYCOLIPIDS OF NORMAL AND PATHOLOGICAL BRAINS
    Robert K Yu; Fiscal Year: 2010
    ..abstract_text> ..
  91. CD1D REACTIVE T CELLS IN BONE MARROW TRANSPLANTATION
    Mark Exley; Fiscal Year: 2002
    ..These preclinical studies are necessary to evaluate the hypothesis that human CD1d-reactive T cells have the therapeutic potential to selectively suppress acute GvH in the context of conventional BM and PBPC transplants for cancer. ..
  92. VIRAL SANCTUARY IN THE CENTRAL NERVOUS SYSTEM
    Carol Petito; Fiscal Year: 2003
    ..The hypotheses and their specific aims address the central goal and selective subaims of RFA #NS99-002, "Central Nervous System as the HIV Sanctuary". ..
  93. Markers of olfactory neurotransmission in Schizophrenia
    Lise Rioux; Fiscal Year: 2004
    ..The effect of the antipsychotic on the expression of these proteins will also be investigated in mice chronically treated with haloperidol to discriminate between disease- and treatment related changes. ..
  94. Alcohol Dependence Genetics in a Large Chinese Pedigree
    Joel Gelernter; Fiscal Year: 2008
    ..This study will improve understanding of the genes that influence risk for alcohol dependence, in Chinese populations, and in comparison with European-American populations. [unreadable] [unreadable] [unreadable]..
  95. 1/5-The Psychiatric GWAS Consortium: Integrated & Coordinated GWAS Meta-Analyses
    Patrick Sullivan; Fiscal Year: 2008
    ..Finally, the PGC proposes to abide as fully as possible with the NIH's GWAS data sharing policies and we provide a detailed data sharing plan and timetable. [unreadable] [unreadable] [unreadable]..
  96. Aging, physical activity and toll-like receptor 4.
    Michael Flynn; Fiscal Year: 2003
    ..These experiments will help to determine whether age and physical activity related differences in cytokine production are linked to TLR4 and whether heat shock proteins play a role in TLR4 regulation. ..
  97. Prevention of PTSD with Early Cortisol Treatment
    Douglas Delahanty; Fiscal Year: 2007
    ..abstract_text> ..
  98. Neuropeptide Y and dipeptidyl-peptidase IV (CD26) in chronic fatigue syndrome
    Mary Fletcher; Fiscal Year: 2007
    ..Specific Aim 3 is to define the relationship of NPY and CD26 to NKCC in CFS. Specific Aim 4 is to determine the relationship of NPY and CD26 to clinical severity in CFS patients. [unreadable] [unreadable] [unreadable]..