Gene Symbol: CD48
Description: CD48 molecule
Alias: BCM1, BLAST, BLAST1, MEM-102, SLAMF2, hCD48, mCD48, CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, CD48 antigen (B-cell membrane protein), SLAM family member 2, TCT.1, leukocyte antigen MEM-102, signaling lymphocytic activation molecule 2
Species: human

Top Publications

  1. ncbi Coexpression of CD58 or CD48 with intercellular adhesion molecule 1 on target cells enhances adhesion of resting NK cells
    Domingo F Barber
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 1727, USA
    J Immunol 170:294-9. 2003
  2. ncbi Activating interactions in human NK cell recognition: the role of 2B4-CD48
    H Nakajima
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1676-83. 1999
  3. pmc Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3
    Y W Wong
    Medical Research Council Cellular Immunology Research Unit, Sir William Dunn School of Pathology, University of Oxford, England
    J Exp Med 171:2115-30. 1990
  4. ncbi The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1
    V Korinek
    Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha
    Immunogenetics 33:108-12. 1991
  5. ncbi The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation
    D Garnett
    MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, GB
    Eur J Immunol 23:2540-4. 1993
  6. ncbi [Ataxia telangiectasia and characterization of its immunological disorders]
    S Matsumoto
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo
    No To Hattatsu 22:103-11. 1990
  7. ncbi Identification, purification and characterization of a putative novel growth-inhibitory and/or apoptotic protein from rat liver
    S S Dadke
    Cellular Carcinogenesis Laboratory, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India
    Tumori 84:14-20. 1998
  8. ncbi Lymphoepithelioma-like carcinoma of the lung. Two cases diagnosed in Caucasian patients
    G Ferrara
    Servizio di Anatomia Patologica, Azienda Ospedaliera Gaetano Rummo, Benevento, Italy
    Tumori 81:144-7. 1995
  9. ncbi [Non-Hodgkin's lymphoma complicated by recurrent intractable generalized herpes zoster responsive to long-term acyclovir therapy]
    K Endo
    First Department of Internal Medicine, Saitama Medical School
    Kansenshogaku Zasshi 73:341-5. 1999
  10. ncbi Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells
    A B Deora
    Chemotherapy and Stem Cell Biology Division, Tata Memorial Center, Parel, Mumbai, India
    Tumori 83:756-61. 1997

Detail Information

Publications1279 found, 100 shown here

  1. ncbi Coexpression of CD58 or CD48 with intercellular adhesion molecule 1 on target cells enhances adhesion of resting NK cells
    Domingo F Barber
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 1727, USA
    J Immunol 170:294-9. 2003
    ..Coexpression of either LFA-3 (CD58) or CD48 with ICAM-1 resulted in strong adhesion by resting NK cells, even in the absence of cytokines...
  2. ncbi Activating interactions in human NK cell recognition: the role of 2B4-CD48
    H Nakajima
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1676-83. 1999
    ..Recently, 2B4 was shown to bind CD48 by molecular binding assays and surface plasmon resonance...
  3. pmc Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3
    Y W Wong
    Medical Research Council Cellular Immunology Research Unit, Sir William Dunn School of Pathology, University of Oxford, England
    J Exp Med 171:2115-30. 1990
    The mouse BCM1 (OX45, Blast-1) antigen has been cDNA cloned and sequenced to provide data supporting the view that BCM1, LFA3, and CD2 constitute a subgroup within the Ig superfamily...
  4. ncbi The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1
    V Korinek
    Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha
    Immunogenetics 33:108-12. 1991
    ..between the broad pan-leucocyte expression of the between the broad pan-leucocyte expression of the MEM-102/CD48 antigen and much more restricted expression of the epitope recognized by the previously described mAb defining the ..
  5. ncbi The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation
    D Garnett
    MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, GB
    Eur J Immunol 23:2540-4. 1993
    ..from detergent lysates and in vitro immune complex kinase reactions the GPI-anchored molecules Thy-1 and CD48 are shown to be associated with multimolecular complexes of phosphoproteins including the protein tyrosine kinases ..
  6. ncbi [Ataxia telangiectasia and characterization of its immunological disorders]
    S Matsumoto
    Department of Pediatrics, Hokkaido University School of Medicine, Sapporo
    No To Hattatsu 22:103-11. 1990
    ..levels of CD 3 and CD 4 positive T lymphocytes, impaired delayed hypersensitivity, hypoplasia of thymus, decreased blast transformation in vitro in response to mitogen or antigenic stimulation, and decreased levels of serum IgA, IgE, ..
  7. ncbi Identification, purification and characterization of a putative novel growth-inhibitory and/or apoptotic protein from rat liver
    S S Dadke
    Cellular Carcinogenesis Laboratory, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India
    Tumori 84:14-20. 1998
    ..Comparing this sequence using a BLAST protein data base indicated that there was no significant homology between the sequence of the growth-inhibitory ..
  8. ncbi Lymphoepithelioma-like carcinoma of the lung. Two cases diagnosed in Caucasian patients
    G Ferrara
    Servizio di Anatomia Patologica, Azienda Ospedaliera Gaetano Rummo, Benevento, Italy
    Tumori 81:144-7. 1995
    ..The neoplastic nuclei, blast-like in appearance, together with the immunohistochemical profile of the neoplastic cells (positivity for ..
  9. ncbi [Non-Hodgkin's lymphoma complicated by recurrent intractable generalized herpes zoster responsive to long-term acyclovir therapy]
    K Endo
    First Department of Internal Medicine, Saitama Medical School
    Kansenshogaku Zasshi 73:341-5. 1999
    ..Involvement of the central nervous system and meninges was diagnosed on September 12, 1997. Blast cells were detected in the peripheral blood on September 26...
  10. ncbi Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells
    A B Deora
    Chemotherapy and Stem Cell Biology Division, Tata Memorial Center, Parel, Mumbai, India
    Tumori 83:756-61. 1997
    ..They are blast cells...
  11. ncbi [Background and prognostic factors of fungemia in patients with hematological disease]
    H Ujiie
    Fifth Department of Internal Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases
    Kansenshogaku Zasshi 72:912-7. 1998
    ..patients with following factors: 1) advanced disease, such as relapse of acute leukemia or malignant lymphoma or blast crisis of chronic myelogenous leukemia; 2) neutrophil count less than 100/microliter; 3) administration of ..
  12. ncbi Clinical evaluation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing instant and lasting relief of dentin hypersensitivity
    Thomas Schiff
    Scottsdale Center for Dentistry, San Francisco, California, USA
    Am J Dent 22:8A-15A. 2009
  13. pmc Fibrin glue eliminates the need for packing after complex liver injuries
    A J Feinstein
    Department of Surgery, University of Miami School of Medicine, FL 33101, USA
    Yale J Biol Med 74:315-21. 2001
    ..Anesthetized swine (n = 6, 18 to 19 kg) received an external blast to the right upper abdomen and were immediately anticoagulated with intravenous heparin (200 u/kg)...
  14. ncbi Lymphocyte transformation in cutaneous leishmaniasis patients
    P G Sells
    Department of Tropical Medicine, Liverpool School of Tropical Medicine
    Ann Trop Med Parasitol 81:105-16. 1987
    ..and phytohaemagglutinin (PHA) were measured in twenty-three cutaneous leishmaniasis patients, using the lymphocyte blast transformation test (LTT)...
  15. ncbi Levamisole in the treatment of advanced breast cancer. A ten-year follow-up of a randomized study
    P Klefström
    Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland
    Acta Oncol 30:347-52. 1991
    ..The results correlated with potentiation of intracutaneous PPD test. In the lymphocyte blast transformation tests, the suppression of T-cell response to mitogens two weeks after the start of chemotherapy was ..
  16. ncbi The BLAST algorithms: practical application in molecular cloning, marker-assisted selection (MAS) and introgression of wheat
    P Hernandez
    Instituto de Agricultura Sostenible CSIC, Cordoba, Spain
    DNA Seq 11:339-47. 2000
    b>BLAST (Basic Local Alignment Search) analyses of Hordeum chilense RAPD markers have shown DNA sequence similarities with several plant genes...
  17. ncbi Kit ligand/mast cell growth factor-independent differentiation of mast cells in myelodysplasia and chronic myeloid leukemic blast crisis
    P Valent
    Department of Internal Medicine, University of Vienna, Austria
    Blood 84:4322-32. 1994
    ..Of the 52 patients tested, 2 patients with refractory anemia with excess of blast cells in transformation and 1 patient suffering from chronic myeloid leukemia blast crisis (CML-BC) were diagnosed ..
  18. ncbi Pathologic features of suicidal deaths caused by explosives
    M Tsokos
    Institute of Legal Medicine, University of Hamburg, Butenfeld 34, 22529 Hamburg, Germany
    Am J Forensic Med Pathol 24:55-63. 2003
    ..All explosions were set off in confined spaces. The injury patterns consisted of a combination of primary blast injuries (e.g...
  19. ncbi Immunotoxicity of cocaethylene
    F Chiappelli
    Laboratory of Human Oral and Molecular Immunology, UCLA School of Dentistry 90024-1668, USA
    Immunopharmacol Immunotoxicol 17:399-417. 1995
    ..The formation of concanavalin A-induced blast cells was decreased by increasing concentrations of cocaethylene...
  20. ncbi Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride relative to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm
    S Nathoo
    Oral Health Clinical Services LLC, Piscataway, NJ, USA
    J Clin Dent 20:123-30. 2009
  21. ncbi Effects of lentinan on cytotoxic functions of human lymphocytes
    G Peter
    Second Department of Medicine, Semmelweis University, Budapest, Hungary
    Immunopharmacol Immunotoxicol 10:157-63. 1988
    ..cell-mediated cytotoxicity (ADCC), lectin-dependent cell-mediated cytotoxicity (LDCC) and mitogen-induced blast transformation were studied in patients with solid tumors and chronic lymphocytic leukemia (CLL)...
  22. ncbi Eye injuries in twentieth century warfare: a historical perspective
    T Y Wong
    Singapore National Eye Center, Singapore
    Surv Ophthalmol 41:433-59. 1997
    ..The main causes of eye injury have changed with advances in techniques and weaponry of warfare, with blast fragmentation injuries accounting for 50-80% of cases...
  23. doi Tympanic membrane perforation after combat blast exposure in Iraq: a poor biomarker of primary blast injury
    Corey D Harrison
    Department of Emergency Medicine, UMassMemorial Medical Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Trauma 67:210-1. 2009
    ..Otologic blast injury and tympanic membrane (TM) perforation have traditionally been used as a predictor, or biomarker, of ..
  24. ncbi Immunotherapy in chronic brucellosis. Effect of levamisole and interferon; mechanisms of action and clinical value
    S Printzis
    2nd Medical Department, Aristotelian University, Thessaloniki, Greece
    Immunopharmacol Immunotoxicol 16:679-93. 1994
    ..The effect of treatment on T lymphocyte blast formation in the presence of PHA, specific cell mediated immunity against brucella antigens, titers of brucella ..
  25. ncbi Fractionated cyclophosphamide added to the IVAP regimen (idarubicin-vincristine-L-asparaginase-prednisone) could lower the risk of primary refractory disease in T-lineage but not B-lineage acute lymphoblastic leukemia: first results from a phase II clinic
    R Bassan
    Ematologia, Ospedali Riuniti, Largo Barozzi 1, 24100 Bergamo, Italy
    Haematologica 84:1088-93. 1999
    ..incidence being higher in T-cell or Philadelphia (Ph) chromosome/BCR-ABL rearrangement positive ALL cases with a blast cell count >25x10(9)/L (RES-ALL rate 19%, p=0.04)...
  26. ncbi [Clinical significance of gastrointestinal decontamination under protected environment]
    T Nagao
    Fourth Department of Internal Medicine, School of Medicine, Tokai University
    Kansenshogaku Zasshi 65:40-6. 1991
    ..Thirty-eight patients with acute leukemia and two patients with blast crisis of chronic myelocytic leukemia were treated under a protected environment with or without prophylactic ..
  27. ncbi The clinical effect of a single direct topical application of a dentifrice containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride on dentin hypersensitivity: the use of a cotton swab applicator versus the use of a fingertip
    T Schiff
    Scottsdale Center for Dentistry, San Francisco, CA, USA
    J Clin Dent 20:131-6. 2009
    ..A secondary objective was to evaluate the effect on dentin hypersensitivity of the dentifrice after seven days of twice-daily at-home brushing, subsequent to the single direct topical application performed at the beginning of the study...
  28. doi The proto-oncogene expression varies over the course of chronic myeloid leukemia
    Ana Vidovic
    Institute of Hematology, Clinical Center of Serbia, Belgrade, Serbia
    Hematology 13:34-40. 2008
    ..The accelerated phase (AP) and blast crisis (BC) of CML are usually manifested by additionally acquired oncogene aberrations, resistance to therapy, ..
  29. ncbi Multiparametric evaluation of retinoic acid-induced terminal differentiation of blastoid cells from acute non-lymphocytic leukemia patients in vitro
    K S Joshi
    Cancer Research Institute, Tata Memorial Centre, Bombay, India
    Tumori 75:435-42. 1989
    ..induces terminal granulocytic differentiation of the human promyelocytic leukemia cell line HL-60 in vitro and blast cell maturation in patients suffering from acute non-lymphocytic leukemia (ANLL) prompted an investigation on the ..
  30. ncbi Replantation and revascularization at the transmetacarpal level: long-term functional results
    N Weinzweig
    Division of Plastic Surgery, University of Illinois at Chicago 60612 7316, USA
    J Hand Surg Am 21:877-83. 1996
    ..Ten patients (11 hands) sustained crush injuries, 1 withstood an explosive blast, and 1 suffered a guillotine amputation...
  31. pmc Genome signature analysis of thermal virus metagenomes reveals Archaea and thermophilic signatures
    David T Pride
    Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA
    BMC Genomics 9:420. 2008
    ..However, study of viral metagenomes has been hampered by its nearly complete reliance on BLAST algorithms for identification of DNA sequences...
  32. ncbi Leukocyte interferon in the treatment of chronic myelogenous leukemia in second chronic phase
    A Wahlin
    Department of Medicine, University Hospital, , Sweden
    Acta Oncol 30:611-5. 1991
    ..treated with 18-42 x 10(6) IU of purified natural leukocyte IFN-alpha per week, after high-dose chemotherapy for blast phase and attainment of 2nd chronic phase...
  33. ncbi Secretion of neutral and acid DNases in cultivated human lymphocytes after incubation with DNA; possible consequences for inhalation anesthesia
    M Reitz
    , , Bundesrepublik Deutschland
    Z Naturforsch C 50:419-24. 1995
    ..The released DNase activities do not originate from dead cells and are not influenced by blast cell formation. The anesthetic halothane can inhibit the released neutral and acid DNase activities...
  34. ncbi Pharmacodynamic and DNA methylation studies of high-dose 1-beta-D-arabinofuranosyl cytosine before and after in vivo 5-azacytidine treatment in pediatric patients with refractory acute lymphocytic leukemia
    V I Avramis
    Department of Pediatrics, School of Medicine, University of Southern California, Childrens Hospital of Los Angeles 90027
    Cancer Chemother Pharmacol 24:203-10. 1989
    The primary development of clinical resistance to 1-beta-D-arabinofuranosyl cytosine (ara-C) in leukemic blast cells is expressed as decreased cellular concentrations of its active anabolite...
  35. ncbi [Clinical efficacy and side effects of STI571 in treatment of patients with chronic myeloid leukemia]
    Xiao Li Liu
    Department of Hematology, Nanfang Hospital, The First Military Medical University, Guangzhou, Guangdong, 510515, PR China
    Ai Zheng 23:421-5. 2004
    ..and greatly improve the clinic curative effect on CML in chronic phase, its effect on CML in accelerated phase and blast crisis is not clear...
  36. ncbi Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate
    Yin Xu
    Department of Pathology and Laboratory Medicine, University of Minnesota School of Medicine, Minneapolis, USA
    Arch Pathol Lab Med 128:980-5. 2004
    ..In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.
  37. pmc Injuries to the bowel and bladder
    E E Cornwell
    Division of Trauma Critical Care, Howard University College of Medicine, Washington, DC
    J Natl Med Assoc 84:971-2. 1992
    ..Intestinal perforations following penetrating trauma are caused by direct penetration or by blast effect, and are most commonly diagnosed by physical examination (signs of peritoneal irritation) or peritoneal ..
  38. ncbi Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis
    Stefan Fruehauf
    Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cancer 109:1543-9. 2007
    ..allogeneic stem cell transplantation (allo-SCT), the prognosis of patients with chronic myeloid leukemia (CML) in blast crisis remains poor...
  39. ncbi Non-explosive blast injury of the tympanic membrane in Umuahia, Nigeria
    F T Orji
    Department of Otolarlaryngology, University of Nigeria Teaching Hospital Ituku Ozalla, Enugu State, Nigeria
    Niger J Med 18:365-9. 2009
    To examine the clinical features and causes of non-explosive blast injury to the ear, as well as the frequency of the State police involvement.
  40. pmc Homotypic cell to cell cross-talk among human natural killer cells reveals differential and overlapping roles of 2B4 and CD2
    Eun Ok Kim
    Department of Biochemistry, Division of Brain Korea 21 Program for Biomedical Science, Global Research Lab, Korea University College of Medicine, Seoul, Korea
    J Biol Chem 285:41755-64. 2010
    Human natural killer (NK) cells express an abundant level of 2B4 and CD2 on their surface. Their counter-receptors, CD48 and CD58, are also expressed on the NK cell surface, raising a question about the functional consequences of ..
  41. ncbi Isochromosome 17q in blast crisis of chronic myeloid leukemia and in other hematologic malignancies is the result of clustered breakpoints in 17p11 and is not associated with coding TP53 mutations
    T Fioretos
    Department of Clinical Genetics, Lund University Hospital, Sweden
    Blood 94:225-32. 1999
    ..We have analyzed 21 hematologic malignancies (8 CML in blast crisis, 8 myelodysplastic syndromes [MDS], 2 acute myeloid leukemias, 2 chronic lymphocytic leukemias, and 1 acute ..
  42. pmc IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
    A Tefferi
    Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Leukemia 24:1302-9. 2010
    ..thrombocythemia (ET), 421 polycythemia vera (PV), 312 primary myelofibrosis (PMF), 95 post-PV/ET MF and 51 blast-phase MPN. A total of 38 IDH mutations (18 IDH1-R132, 19 IDH2-R140 and 1 IDH2-R172) were detected: 5 (0...
  43. ncbi Gunshot wound injury of the testis: the use of tunica vaginalis and polytetrafluoroethylene grafts for reconstruction
    Genoa Goetz Ferguson
    Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Urol 178:2462-5. 2007
    Gunshot wounds to the scrotum and testis are rare. Blast injury from gunshot wounds can result in blast defects that are difficult to close...
  44. ncbi Outcome of tissue sparing surgical intervention in mine blast limb injuries
    Mohammad Iqbal Khan
    Department of Surgery, Islamic International Medical College, Rawalpindi
    J Coll Physicians Surg Pak 16:773-6. 2006
    To describe the pattern of mine blast limb injuries in civilian population of Kashmir, to evaluate the outcome of tissue sparing surgical intervention in these injuries and to determine the sensitivity of hand-held percutaneous Doppler ..
  45. pmc Polyphasic taxonomic analysis establishes Mycobacterium indicus pranii as a distinct species
    Vikram Saini
    Department of Biochemistry, University of Delhi South Campus, New Delhi, India
    PLoS ONE 4:e6263. 2009
    ..vaccae. The novelty of this bacterium was accredited to its immunological ability to undergo antigen driven blast transformation of leukocytes and delayed hypersensitivity skin test in leprosy patients, a disease endemic in the ..
  46. ncbi Chronic myeloid leukemia with monoclonal gammopathy terminating in myeloid crisis and immunoblastic lymphoma
    L M Larocca
    Instituti di Anatomia Patologica, , Roma, Italy
    Tumori 75:106-9. 1989
    A patient, with chronic myeloid leukemia and IgA monoclonal gammopathy, who contemporaneously developed myeloid blast crisis and immunoblastic lymphoma is reported...
  47. ncbi Chemical and mineralogical characterization of blast-furnace sludge from an abandoned landfill
    Tim Mansfeldt
    Arbeitsgruppe Bodenkunde and Bodenökologie, Fakultät für Geowissenschaften, Ruhr Universitat Bochum, D 44780 Bochum, Germany
    Environ Sci Technol 38:5977-84. 2004
    b>Blast-furnace sludge is generated during the production of pig iron and is disposed of in the environment in large surface landfills...
  48. ncbi [Blast injuries of the hands. Patterns of trauma and plastic surgical treatment]
    G A Giessler
    Berufsgenossenschaftliche Unfallklinik Ludwigshafen, Plastische und Handchirurgie der Universität Heidelberg, Ludwig Guttmann Strasse 13, 67071 Ludwigshafen, Deutschland
    Unfallchirurg 109:956-63. 2006
    b>Blast injuries of the hand represent a demanding surgical emergency for the reconstructive hand surgeon...
  49. doi Characteristics and rehabilitation outcomes among patients with blast and other injuries sustained during the Global War on Terror
    Nina A Sayer
    Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN 55417, USA
    Arch Phys Med Rehabil 89:163-70. 2008
    To describe characteristics and rehabilitation outcomes among patients who received inpatient rehabilitation for blast and other injuries sustained in Iraq and Afghanistan during the Global War on Terror.
  50. ncbi Blast injury of the ears: the experience from Yala Hospital, Southern Thailand
    Sunee Tungsinmunkong
    Otolaryngology Unit, Yala Provincial Hospital, Yala, Thailand
    J Med Assoc Thai 90:2662-8. 2007
    To report acute and subacute consequences of blast injury to the ear from terrorists' bombings experienced from Yala Provincial Hospital, Southern Thailand
  51. ncbi N-ras mutations in myeloid leukemias
    G Saglio
    , Italy
    Tumori 75:337-40. 1989 onset and in four patients with Ph1 positive chronic myelogeneous leukemia (CML) either in chronic phase or in blast crisis. Four remission samples and four relapses from the AML cases were also studied...
  52. ncbi Blast injury in a civilian trauma setting is associated with a delay in diagnosis of traumatic brain injury
    Grant V Bochicchio
    R Adams Cowley Shock Trauma Center, Division of Clinical and Outcomes Research, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am Surg 74:267-70. 2008
    High-pressure waves (blast) account for the majority of combat injuries and are becoming increasingly common in terrorist attacks...
  53. ncbi Pathology of blast-related brain injury
    Jeffery D Kocsis
    Yale University School of Medicine, Neuroscience Research Center 127A, VA CT Healthcare System, West Haven, CT 06516, USA
    J Rehabil Res Dev 46:667-72. 2009
    ..Direct injuries to the brain result from rapid shifts in air pressure (primary blast injury), from impacts with munitions fragments and other objects propelled by the explosion (secondary blast ..
  54. pmc Prognostic study of continuous variables (white blood cell count, peripheral blast cell count, haemoglobin level, platelet count and age) in childhood acute lymphoblastic leukaemia. Analysis Of a population of 1545 children treated by the French Acute Lym
    J Donadieu
    , Institut Gustave Roussy, rue Camille Desmoulins, Villejuif, 94800, France
    Br J Cancer 83:1617-22. 2000 categorize continuous variables in childhood acute lymphoblastic leukaemia (white blood cell count, peripheral blast cell count, haemoglobin level, platelet count and age), and have been used to define therapeutic subgroups...
  55. pmc TF Target Mapper: a BLAST search tool for the identification of Transcription Factor target genes
    Sebastiaan Horsman
    Department of Cell Biology, Erasmus Medical Center, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
    BMC Bioinformatics 7:120. 2006
    ..Routinely, thousands of such sequenced clones are used in BLAST searches to map their exact location in the genome and the genes located in the vicinity...
  56. ncbi Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    B J Druker
    Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland 97201, USA
    N Engl J Med 344:1038-42. 2001 patients in the chronic phase, we evaluated STI571 (formerly known as CGP 57148B), a specific inhibitor of the BCR-ABL tyrosine kinase, in patients who had CML in blast crisis and in patients with ALL who had the Ph chromosome.
  57. doi Biomechanical assessment of brain dynamic responses due to blast pressure waves
    M S Chafi
    Department of Mechanical Engineering and Applied Mechanics, North Dakota State University, Fargo, ND 58105 5285, USA
    Ann Biomed Eng 38:490-504. 2010
    ..element method (FEM) that implements a simultaneous conduction of explosive detonation, shock wave propagation, blast-head interactions, and the confronting human head...
  58. doi What is the role of JAK2(V617F) mutation in leukemic transformation of myeloproliferative neoplasms?
    Rodrigo Lopes da Silva
    Servico de Hematologia, Hospital Santo António dos Capuchos CHLC, Lisboa, Portugal
    Lab Hematol 17:12-6. 2011
    ..The aim of this study was to evaluate both the JAK2(V617F) mutational status of the rare cases in which blast crisis occurred in our institution and the response after intensive treatment.
  59. ncbi Predictors of mortality in close proximity blast injuries during Operation Iraqi Freedom
    Thomas J Nelson
    Department of Surgery, Naval Hospital Camp Pendleton, Marine Corps Base, Camp Pendleton, CA 92055, USA
    J Am Coll Surg 202:418-22. 2006
    b>Blast injury is an increasingly common problem faced by military surgeons in the field. Because of urban terrorism worldwide, blast injury is becoming more common in the civilian sector as well...
  60. pmc Fold-recognition and comparative modeling of human alpha2,3-sialyltransferases reveal their sequence and structural similarities to CstII from Campylobacter jejuni
    M S Sujatha
    School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India
    BMC Struct Biol 6:9. 2006
    ..Sequence alignment algorithms such as BLAST and PSI-BLAST could not detect a homolog of these enzymes from the protein databank...
  61. ncbi Susceptibility of rice to the blast fungus, Magnaporthe grisea
    Cecile Ribot
    UMR 5240 CNRS UCB INSA BCS, Bayer CropScience, 14 20 rue Pierre Baizet BP9163, 69263 Lyon Cedex 09, France
    J Plant Physiol 165:114-24. 2008
    The interaction between rice and the blast fungus Magnaporthe grisea is the focus of extensive studies on rice disease resistance and fungal infection mechanisms...
  62. ncbi Influence of spray equipment and water volume on coverage of citrus and control of citricola scale, Coccus pseudomagnoliarum (Hemiptera: Coccidae) with mineral oil
    P Chueca
    Centro de Agroingeniería, Instituto Valenciano de Investigaciones Agrarias IVIA, Ctra de Moncada a Náquera km 4, 5, Moncada 46113 Valencia, Spain
    J Econ Entomol 102:296-303. 2009
    ..5 liters/ha of an nC24 agricultural mineral oil treatment applied by two different methods: a conventional air blast sprayer and a rotary atomizer...
  63. pmc Human embryonic stem cells hemangioblast express HLA-antigens
    Grzegorz Wladyslaw Basak
    Rebecca and John Moore s Cancer Center, University of California, La Jolla, CA 92093, USA
    J Transl Med 7:27. 2009
    ..We hypothesized that these cells with dual hematopoietic/endothelial potential could be used in future regenerative medicine...
  64. ncbi Cognitive deficits following blast injury-induced neurotrauma: possible involvement of nitric oxide
    I Cernak
    Institute for Medical Research, Military Medical Academy, Belgrade, Yugoslavia
    Brain Inj 15:593-612. 2001
    b>Blast injuries, that is injuries caused by the complex pressure wave generated by some explosions, show increasing frequency throughout the world...
  65. ncbi Blast lung injury
    Scott M Sasser
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Prehosp Emerg Care 10:165-72. 2006
    ..This results in the formation of a blast wave that travels out from the epicenter of the blast...
  66. doi Computational biology - modeling of primary blast effects on the central nervous system
    David F Moore
    Defense and Veterans Brain Injury Center, Walter Reed Army Medical Center, Building 1, Room B207, 6900 Georgia Avenue NW, Washington DC 20309 5001, USA
    Neuroimage 47:T10-20. 2009 these particular conflicts as opposed to others is unclear but may result from the increased survivability of blast due to improvements in body armor...
  67. ncbi Binding properties and proliferative effects of human recombinant granulocyte-macrophage colony-stimulating factor in primary leukemia and lymphoma
    Y F Piao
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
    Jpn J Cancer Res 80:887-94. 1989
    Binding of radiolabeled human granulocyte-macrophage colony-stimulating factor (GM-CSF) was studied with blast cells from eight patients with acute myeloblastic leukemia (AML), and neoplastic lymphoid cells from one patient with acute ..
  68. pmc Blast injury research models
    E Kirkman
    Biomedical Sciences, Dstl Porton Down, Salisbury SP4 0JQ, UK
    Philos Trans R Soc Lond B Biol Sci 366:144-59. 2011
    b>Blast injuries are an increasing problem in both military and civilian practice...
  69. ncbi Traumatic axial dislocations of the carpus
    M Garcia Elias
    Department of Orthopedics, Mayo Clinic Mayo Foundation, Rochester, Minn 55905
    J Hand Surg Am 14:446-57. 1989
    ..Most of these were crush or blast injuries...
  70. ncbi Primary blast injuries to the eye: a review of the evidence
    R Abbotts
    Biomedical Sciences, Defence Science and Technology Laboratory, Porton, Salisbury, SP4 0JQ
    J R Army Med Corps 153:119-23. 2007
    ..The majority of these are caused by secondary fragments. Primary blast injury to the eye (from the air-blast alone) has been described historically, but the differentiation of air-blast ..
  71. ncbi Bomb blast mass casualty incidents: initial triage and management of injuries
    S H Goh
    Accident and Emergency Department, Changi General Hospital, Singapore
    Singapore Med J 50:101-6. 2009
    Bomb blast injuries are no longer confined to battlefields. With the ever present threat of terrorism, we should always be prepared for bomb blasts...
  72. ncbi Effect of dipyridamole, theophyllamine and verapamil on spontaneous in vitro proliferation of myelogenous leukaemia cells
    O Bruserud
    Medical Department, Haukeland Sykehus, Bergen, Norway
    Acta Oncol 31:53-8. 1992
    ..with acute myelogenous leukaemia (n = 9), chronic myelogenous leukaemia in first chronic phase (n = 4) and blast phase (n = 1)...
  73. doi Physiological and cytological mechanisms of silicon-induced resistance in rice against blast disease
    Kunzheng Cai
    Institute of Tropical and Subtropical Ecology, South China Agricultural University, Guangzhou 510642, China
    Physiol Plant 134:324-33. 2008
    Rice (Oryza sativa L.) blast disease caused by Magnaporthe grisea is one of the most destructive diseases in the rice-growing areas of the world. Silicon is an important nutritional element especially for rice...
  74. ncbi Dynamic axial carpal instability: a case report
    A Y Shin
    Naval Medical Center San Diego, Department of Orthopaedic Surgery, CA, USA
    J Hand Surg Am 24:781-5. 1999
    The concept of distal carpal row dissociation is not new. It has occurred secondary to high-energy crush or blast injuries, with resultant axial dislocations of both carpal rows and metacarpals...
  75. ncbi Imatinib activity in vitro in tumor cells from patients with chronic myeloid leukemia in chronic phase and blast crisis
    Ulla Olsson-Stromberg
    Department of Hematology, University Hospital, Uppsala, Sweden
    Anticancer Drugs 17:631-9. 2006
    ..In nine samples (six chronic phase, three blast crisis), the drug sensitivities in tumor cells from blood versus from bone marrow and fresh tumor cells versus ..
  76. ncbi Traumatic dislocations of the distal carpal row
    C H Pai
    Department of Orthopaedic Surgery, Fangliao General Hospital, Pingtung, Taiwan, Republic of China
    J Hand Surg Br 19:576-83. 1994
    13 patients who sustained high-energy crush or blast injury of the carpal bones were reviewed after a mean follow-up period of 30 months...
  77. ncbi [Intracellular retention of cytarabine-triphosphate (Ara-CTP) in blasts of children with acute lymphoblastic leukemia. Correlation with clinical course parameters]
    M Schiller
    Klinik und Poliklinik für Kinderheilkunde, Westfalische Wilhelms Universitat Munster
    Klin Padiatr 208:151-9. 1996
    ..Therefore, the role of intracellular Ara-CTP formation and retention was investigated in blast cells from children with acute lymphoblastic leukemia (ALL).
  78. ncbi Rays as weapons
    H Vogel
    Asklepios Klinik St Georg, Röntgenabteilung, Lohmuhlenstrasse 5, 20099 Hamburg, Germany
    Eur J Radiol 63:167-77. 2007
    ..However, there are differences between a nuclear bomb explosion, the largest imaginable accident in a nuclear power plant, and an attack with a dirty bomb. It is intended to point them out...
  79. ncbi [A new prognostic stratification for patients with acute myeloid leukemia]
    Bo Jiang
    Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China
    Zhonghua Nei Ke Za Zhi 48:316-20. 2009
    ..To refine AML risk-stratification by combining the percentage of residual blast cells (T1 or/and T2) with cytogenetic data based the South West Oncology Group (SWOG) criteria.
  80. ncbi Morphological diagnoses of the Japan adult leukemia study group acute myeloid leukemia protocols: central review
    K Kuriyama
    Department of Hematology and Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Japan
    Int J Hematol 73:93-9. 2001
    ..The survival of patients with >50% myeloperoxidase (MPO)-positive blast cells was better than those with < or =50% MPO+ blast cells in AML-87/-89...
  81. ncbi Morphologic, immunologic, and cytogenetic characteristics of secondary acute unclassifiable leukemia in Hodgkin's disease
    A Orazi
    Divisione di Anatomia Patologica e Citologia, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italia
    Tumori 74:439-50. 1988
    b>Blast cells from five cases of secondary unclassifiable leukemia following therapy for Hodgkin's disease were studied by cytochemical, immunological and cytogenetic analyses...
  82. ncbi Use of combined myeloperoxidase and immunogold technique in hybrid leukemia: a case report
    V T Shetty
    Electron Microscope Department, Jaslok Hospital and Research Centre, Bombay, India
    Ultrastruct Pathol 16:569-75. 1992
    A case of hybrid leukemia is presented. A 30-year-old man had two blast cell populations with bone marrow...
  83. ncbi Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp
    S E Fisher
    Department of Biochemistry, Oxford University, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Genomics 45:340-7. 1997
    ..Sequence data were extensively analyzed using computer programs such as CENSOR (to mask repeats), BLAST (for homology searches), and GRAIL and GENE-ID (to predict exons)...
  84. ncbi Comparative sequence analyses of sixteen reptilian paramyxoviruses
    W Ahne
    Institute of Zoology, Fishery Biology and Fish Diseases, University of Munich, Germany
    Virus Res 63:65-74. 1999 the hemagglutinin-neuraminidase (HN) and polymerase (L) genes of mammalian paramyxoviruses were identified by BLAST search...
  85. ncbi HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110
    Ying Liu
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 277:23854-63. 2002
    ..GenBank BLAST search revealed that Tip110 was almost identical to a previously cloned KIAA0156 gene with unknown functions...
  86. ncbi Evidence for infanticide in bottlenose dolphins of the western North Atlantic
    Dale G Dunn
    Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    J Wildl Dis 38:505-10. 2002
    ..The lesions were not compatible with predation, boat strike, fisheries interactions, rough-surf injury, or blast injury...
  87. ncbi A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells
    Edward Melkun
    Department of Veterinary Science, The Schreyer s Honors College, and the Graduate Program in Biochemistry, Microbiology and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Blood 100:3804-11. 2002
    ..Fv2 has also been implicated in the control of cell cycling in early erythroid progenitors (erythroid blast-forming units [BFU-Es])...
  88. pmc A comparison of common programming languages used in bioinformatics
    Mathieu Fourment
    Department of Biological Sciences, Macquarie University, Sydney, NSW 2109, Australia
    BMC Bioinformatics 9:82. 2008
    ..Programs for the Sellers algorithm, the Neighbor-Joining tree construction algorithm and an algorithm for parsing BLAST file outputs were implemented in C, C++, C#, Java, Perl and Python.
  89. doi Possible ancient origin of heterochromatic JNK sequences in chromosomes 2R of Secale vavilovii Grossh
    M Achrem
    University of Szczecin, Faculty of Natural Sciences, Chair of Cell Biology, Waska 13, 71 415 Szczecin, Poland
    J Appl Genet 51:1-8. 2010
    Employing FISH analysis as well as BLAST and CUSTAL W (1.82) programs, we investigated types of DNA nucleotide sequences building an additional heterochromatic band in 2R chromosomes of 3 lines of Secale vavilovii Grossh...
  90. doi Characterization of rice nucleotide sugar transporters capable of transporting UDP-galactose and UDP-glucose
    Junichi Seino
    Glyco chain Functions Laboratory, RIKEN FRS, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biochem 148:35-46. 2010
    Using the basic local alignment search tool (BLAST) algorithm to search the Oryza sativa (Japanese rice) nucleotide sequence databases with the Arabidopsis thaliana UDP-galactose transporter sequences as queries, we found a number of ..
  91. doi Molecular cloning, characterization and expression analysis of heat shock protein 90 from Pacific abalone, Haliotis discus hannai Ino in response to dietary selenium
    Wenbing Zhang
    The Key Laboratory of Mariculture, Education Ministry of China, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China
    Fish Shellfish Immunol 30:280-6. 2011
    ..134 kDa and theoretical isoelectric point of 4.619. BLAST analysis revealed that HdhHSP90 shared high similarity with other known HSP90s, and the five conserved amino acid ..
  92. ncbi Expression specificity of CBP1 is regulated by transcriptional repression during vegetative growth of Magnaporthe oryzae
    Yuichi Nakajima
    Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan
    J Gen Appl Microbiol 56:437-45. 2010
    The rice blast fungus Magnaporthe oryzae produces appressoria during the infection of a host. In M...
  93. pmc Trisomy 11 as an isolated abnormality in acute myeloid leukemia is associated with unfavorable prognosis but not with an NPM1 or KIT mutation
    Faisal M Alseraye
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA
    Int J Clin Exp Pathol 4:371-7. 2011
    ..Only 1 patient achieved complete remission after undergoing stem cell transplantation. The bone marrow median blast count was 65% (range, 22 to 86) and 14 patients had blasts >50%...
  94. doi Comparative genome analysis with the human genome reveals chicken genes associated with fatness and body weight
    T Twito
    Institute of Plant Sciences, ARO Volcani Center, Bet Dagan, Israel
    Anim Genet 42:642-9. 2011
    ..that are associated with obesity and obesity-related traits in humans, for which we found chicken orthologues by BLAST searches...
  95. doi BCR-ABL1 doubling times more reliably assess the dynamics of CML relapse compared with the BCR-ABL1 fold rise: implications for monitoring and management
    Susan Branford
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia
    Blood 119:4264-71. 2012
    ..Distinct groups were examined: (1) acquired clinical resistance because of blast crisis and/or BCR-ABL1 mutations; and (2) documented imatinib discontinuation/interruption...
  96. doi A dissection of the CD45/side scatter "blast gate"
    Alexandra M Harrington
    Department of Pathology, Medical College of Wisconsin, Milwaukee, USA
    Am J Clin Pathol 137:800-4. 2012
    ..However, other cells contaminate the "blast gate" (BG); CD45/SS gating is thus imprecise, particularly when there are few blasts...
  97. doi Development of metal-chelating inhibitors for the Class II fructose 1,6-bisphosphate (FBP) aldolase
    Genevieve Labbe
    Department of Chemistry, University of Waterloo, 200 University Ave W, Waterloo, ON, Canada N2L 3G1
    J Inorg Biochem 112:49-58. 2012
    ..from Mycobacterium tuberculosis, Pseudomonas aeruginosa, Bacillus cereus, Bacillus anthracis, and from the Rice Blast causative agent Magnaporthe grisea. The aldolase from M...
  98. doi Transcriptome-wide polymorphisms of red abalone (Haliotis rufescens) reveal patterns of gene flow and local adaptation
    Pierre De Wit
    Department of Biology, Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA
    Mol Ecol 22:2884-97. 2013
    ..05). From these, it was possible to identify 163 genes through BLAST annotation, 34 of which contained more than one outlier SNP...
  99. doi Blast cell deficiency of CD11a as a marker of acute megakaryoblastic leukemia and transient myeloproliferative disease in children with and without Down syndrome
    Heidrun Boztug
    Department of Pediatrics, St Anna Kinderspital and Children s Cancer Research Institute, Medical University of Vienna, Vienna, Austria
    Cytometry B Clin Cytom 84:370-8. 2013 expressed throughout all stages of maturation of megakaryocytes and has therefore been described as a specific blast cell marker in AML M7 as well as in transient myeloproliferative disease (TMD) of patients with Down syndrome (DS)...
  100. ncbi [Sequence analysis of LEAFY homologous gene from Dendrobium moniliforme and application for identification of medicinal Dendrobium]
    Wen Rui Xing
    College of Life Sciences, Nanjing Normal University, Nanjing 210023, China
    Yao Xue Xue Bao 48:597-603. 2013
    ..The complete sequence of DenLFY gene was 3 575 bp which contained three exons and two introns. Using BLAST method, comparison analysis among the exon of LFY homologous gene indicted that the DenLFY gene had high identity ..
  101. doi Identification of differentially-expressed genes potentially implicated in drought response in pitaya (Hylocereus undatus) by suppression subtractive hybridization and cDNA microarray analysis
    Qing Jie Fan
    Guizhou Key Laboratory of Agricultural Bioengineering, Guizhou University, Guiyang 550025, Guizhou Province, PR China
    Gene 533:322-31. 2014
    ..156 from reverse library, were obtained, and 138 unique ESTs were identified after sequencing by clustering and blast analyses, which included genes that had been previously reported as responsive to water stress as well as some ..

Research Grants77

  1. Clinical and Molecular Biology of Acute and Chronic Traumatic Encephalopathies
    JAMES WAVELL AIKEN; Fiscal Year: 2011 major public health issues, especially in the context of sports-related head injury and battlefield blast (military) exposure...
  2. Frontal Lobe Neuroimaging as a Biomarker of Chronic Traumatic Encephalopathy
    JULIE MARIE STAMM; Fiscal Year: 2012 sports across all levels as well as military personnel who have experienced repetitive brain trauma from blast injuries, an improved understanding of frontal lobe dysfunction in CTE and other factors that influence the ..
  3. Frontal Lobe Injury and Executive Control of Cognition and Emotion
    Diane Swick; Fiscal Year: 2013
    ..previously deployed military personnel have sustained TBIs during their service in OEF and OIF, primarily due to blast injuries. The majority of these injuries can be classified as mild TBI or concussion...
  4. Improved manufacture of bone transport plates
    TIMOTHY MULONE; Fiscal Year: 2009
    ..Furthermore, segmental bone loss may result from blast injuries, high impact trauma, or repeated surgical debridement for treatment of chronic osteomyelitis of the ..
  5. Ameliorating systemic gentamicin uptake by sensory hair cells
    PETER STEPHEN STEYGER; Fiscal Year: 2013
    ..judiciously and personalize gentamicin therapy for individual cases prior to treatment for life-threatening bacterial sepsis, tuberculosis and for prophylaxis in premature babies, and casualties with severe burns and blast injuries.
  6. Cochlear trafficking and hair cell uptake of aminoglycosides
    PETER STEPHEN STEYGER; Fiscal Year: 2013
    ..uptake of aminoglycosides will allow clinicians to use aminoglycosides more aggressively for treating life-threatening bacterial sepsis, specific agents of bioterrorism, and for prophylaxis in combat, severe burns and blast injuries.
  7. Molecular targets of Corneal Anti-fibrosis
    Royce Mohan; Fiscal Year: 2013
    ..The exposed cornea is first to also become involved in ocular infections, chemical or blast injuries, and rapidly develops angiogenesis and fibrosis, which ultimately leads to scarring and corneal blindness...
  8. Vestibular Consequences of Blast-related Mild Traumatic Brain Injury
    FAITH AKIN; Fiscal Year: 2009
    ..Project Summary: The goal of this project is to determine the effects of mild traumatic brain injury (mTBI) and blast exposure on the vestibular system and CNS...
  9. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..common final pathways which is sufficient for myeloproliferation and necessary for susceptibility to myeloid blast crisis...
  10. Molecular Mechanisms of Disease Progression in Myeloid Malignancy
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..Increased [unreadable]catenin activity in CML- CSC/LSC precedes progression to blast crisis (BC), but does not correlate with Wnt expression or CTNNB1 transcription...
  11. Genome instability in leukemia stem cell
    Tomasz Skorski; Fiscal Year: 2010
    ..resistance to ABL kinase inhibitor imatinib mesylate (IM), and to malignant progression of CML- CP to aggressive blast crisis (CML-BC). Resistance to IM is often caused by mutations encoding amino acid substitutions in BCR/ABL kinase...
  12. The role of ICSBP in the pathogenesis of chronic myeloid leukemia
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..Increased ?catenin activity precedes blast crisis (BC) in CML, but does not correlate with Wnt expression or CTNNB1 transcription...
  13. AID-mediated genetic instability in BCR-ABL1-transformed B cell lineage leukemia
    MARKUS MUSCHEN; Fiscal Year: 2013
    ..In a subgroup of patients with CML, however, the disease progresses into B lymphoid blast crisis (CML-LBC), in which treatment responses are as short-lived as in Ph+ ALL...
  14. Proteasome/HDAC Inhibition in Leukemia/MDS; Phase I Trial and Correlative Studies
    Steven Grant; Fiscal Year: 2010
    ..PXD-101) and the proteasome inhibitor (PI) bortezomib in patients with refractory AML, high-risk MDS, CML-blast crisis, and ALL...
  15. GVL Resistance: Immune selection, T cell ignorance and T cell exhaustion
    Warren D Shlomchik; Fiscal Year: 2013
    ..As we hoped, the CD8+ TM from miHA-vaccinated donors were potent mediators of GVL against a GVL-resistant model of blast crisis CML (mBC-CML) induced by the retroviral transfer of bcr-abl and NUP98-HOXA9 fusion cDNAs...
  16. Leukemia Stem Cells: Essential Targets for GVL and Mediators of GVL-Resistance
    Warren D Shlomchik; Fiscal Year: 2013
    ..The basis for differential susceptibility, even between such closely related leukemias as CP-CML and GVL-resistant blast crisis CML (BC-CML) is unknown...
  17. Role of Setbp1 in leukemic stem cell self-renewal
    Yang Du; Fiscal Year: 2013
    ..and BCR/ABL in the generation and maintenance of LSCs in a mouse model of chronic myeloid leukemia (CML) myeloid blast crisis...
  18. "BCR/ABL-PI-3k-ROS pathway induce genomic instability ...."
    Tomasz Skorski; Fiscal Year: 2013
    ..CML usually starts as a relatively benign chronic phase (CML-CP), which progresses to an aggressive disease - blast crisis (CML-BC)...
  19. Role of RNA Binding Proteins in BCR/ABL Leukemogenesis
    Danilo Perrotti; Fiscal Year: 2012
    ..We extensively reported that altered mRNA metabolism is a key feature of blast crisis CML (CML-BC). Indeed, loss-of-function of tumor suppressors (e.g...
  20. c-Myb fusion proteins in Adenoid Cystic Carcinoma
    Timothy P Bender; Fiscal Year: 2012 bone marrow progenitors transduced with a p210BCR/ABL producing virus and extended survival in a model of CML blast crisis...
  21. Novel SET Antagonists for the Treatment of Chronic Myelogenous Leukemia
    Dale J Christensen; Fiscal Year: 2013
    ..The protracted myelopoliferative chronic phase is followed by a rapidly fatal blast crisis...
  22. c-Myb controls survival, proliferation and differentiation during B-lymphopoiesis
    Timothy P Bender; Fiscal Year: 2013 bone marrow progenitors transduced with a p210BCR/ABL producing virus and extended survival in a model of CML blast crisis...
  23. Bypassing Oncogene Addiction: Mechanisms of off-target resistance in CML
    GABRIEL ANTHONY REYES; Fiscal Year: 2013
    ..The natural history of CML involves progression to a more aggressive disease blast crisis phase, where terminal differentiation is impaired, and the disease exhibits features of acute leukemia...
  24. Oncogene Cooperativity in Leukemia Stem Cells
    Craig T Jordan; Fiscal Year: 2013
    ..identification of "cooperativity response genes" or CRGs in the context of a genetically defined murine model of blast crisis CML...
  25. Targeting the C/EBPalpha-Gfi-pathway in CML stem cells
    Bruno Calabretta; Fiscal Year: 2013
    ..Moreover, its ectopic expression in myeloid leukemia lines and in primary blast cells from chronic myelogenous leukemia (CML)-blast crisis patients induces granulocytic differentiation and ..
  26. Dose-dependent Activation of the MEK/ERK Pathway in Hematopoiesis
    Jing Zhang; Fiscal Year: 2013
    ..determine whether inhibition of MEK1/2 and Jak2 blocks Nras G12D/G12D-mediated MPD and its transformation to a blast crisis...
  27. Sequence Based FISH Analysis of Philadelphia Chromosomes
    JOAN KNOLL; Fiscal Year: 2003
    ..These deletions appear to be prognostic for early blast crisis. We hypothesize that these deletions result in hemizygosity of additional genes adjacent to ABLI...
  28. Nostalgia in the WNT signaling pathway; fatty acids, epigenetics and leukemia
    Vincent Sollars; Fiscal Year: 2009
    ..cancer progression, omega fatty acids, and SFRP methylation a mouse BCR-ABL chronic myelogenous leukemia (CML) blast crisis model will be used. In the first Specific Aim, we will determine the effect of high omega 3 canola oil vs...
    Martin Cline; Fiscal Year: 1993
    Consistent molecular changes associated with the transition of chronic myelocytic leukemia (CML) to blast crisis were not identified until an analysis of the p53 gene in human malignancies revealed a frequent association of alterations ..
    Giuseppina Nucifora; Fiscal Year: 1999
    ..3;21)(q26;q22) is a recurring abnormality in the malignant cells of patients with chronic myelogenous leukemia in blast crisis and with acute myeloid leukemia primarily following treatment with topoisomerase II inhibitors...
  31. Detecting Homology in the "Twilight Zone" of Sequence Similarity
    RANDEN LEE PATTERSON; Fiscal Year: 2012
    ..Results from this Gestalt Domain Detection Algorithm-Basic Local Alignment Tool (GDDA-BLAST) provide phylogenetic profiles that have the capacity to model SF&E relationships of various proteins...
  32. TLS and TLS Fusion Proteins in Leukemia
    Liu Yang; Fiscal Year: 2005
    ..In acute myelogenous leukemia (AMIL), chronic myelogenous leukemia (CML) in blast crisis, and myelodysplastic syndromes, the TLS (translocation liposarcoma) gene is fused to the ERG (ets-related ..
  33. Gleevec plus novel anti-Bcr-Abl strategies in Leukemias
    Kapil Bhalla; Fiscal Year: 2005
    ..However, these studies need to be extended to patient-derived, CD34+ CML-blast crisis (BC) and Bcr-Abl positive ALL progenitor cells...
  34. Therapeutic Mechanisms in Chronic Myelogenous Leukemia
    George Daley; Fiscal Year: 2005
    ..leukocytosis during the initial chronic phase of CML, but does nothing to alter the inevitable development of blast crisis, an acute leukemia that ultimately proves fatal...
  35. Arsenic Based Therapy of Bcr Abl Positive Leukemias
    Kapil Bhalla; Fiscal Year: 2003
    The leukemic clone in virtually all of the patients with chronic myeloid leukemia with blast crisis (CML-BC) and approximately one-third of the adults with acute lymphoblastic leukemia (ALL) expresses the bcr-abl fusion gene encoded p210 ..
  36. Leukemic transformation by the AML1/MDS1/EVI1 Protein
    Archibald Perkins; Fiscal Year: 2009
    ..The t(3;21) occurs in the setting of therapy-related AML, the blast crisis phase of CML, and de novo AML, and is associated with a particularly poor prognosis...
    HIREMAGALUR JAYARAM; Fiscal Year: 1993
    Our recent studies on the treatment of twenty-four patients with end stage acute myeloid leukemia and myeloid blast crisis of granulocytic leukemia with tiazofurin revealed that in this poor prognosis group of patients five attained ..
    Jerry Radich; Fiscal Year: 2003
    ..clinically benign state ( chronic phase ), which invariably evolves to an incurable aggressive disease ( blast crisis )...
  39. CODEHOP: Unique web-based technology for gene discovery
    TIMOTHY ROSE; Fiscal Year: 2009
    ..Unlike the "Basic Local Sequence Alignment Tool (BLAST) used to detect related sequences in silico, CODEHOPs can search for related sequences in the genome content of ..
  40. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    DESCRIPTION (provided by applicant): Mild traumatic brain injury (mTBI) caused by blast effects of explosive devices is the "signature injury" of the current Iraq and Afghanistan conflicts, affecting an estimated 18% of deployed ..
  41. Essential Features of Neural Damage in Mild Traumatic Brain Injury
    Scott R Sponheim; Fiscal Year: 2012
    ..intervention allow soldiers to survive explosions, a growing number of veterans will have disability stemming from blast-related brain damage...
  42. A Mouse Model for Emotional Disorder Caused by Mild Traumatic Brain Injury
    ANTON J REINER; Fiscal Year: 2013
    ..Mild TBI involves closed-head injury from a primary blast shock wave, or head acceleration - deceleration during a collision...
  43. Blast Wave Effects: Hearing, Memory, Therapy
    Richard J Salvi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Blast wave explosions are a major cause of hearing loss among military personnel, but blasts can also induce traumatic brain injury and impair memory...
  44. Regulation of Calcium Signaling in Retinal Ganglion Cells after Nerve Injury
    Nicholas C Brecha; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ocular and traumatic brain injuries (TBI) from blunt trauma or blast injury to the head occur with high frequency on the battlefield, and they are often accompanied by multiple visual dysfunctions, ..
  45. NIH Director's Pioneer Award
    Junying Yuan; Fiscal Year: 2009
    ..No Abstract provided ..
  46. Contribution of blast wave components to mild traumatic brain injury
    DEXTER VINCENT RENEER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Blast-induced Traumatic brain injury (bTBI) has become the "signature injury" of Operations Iraqi/Enduring Freedom (OIF/OEF) and is also increasingly frequent in civilians as a result of industrial ..
  47. Central Auditory Processing Deficits Associated with Blast Exposure
    Marjorie R Leek; Fiscal Year: 2012
    ..Dennis (2009) reports that during 2005-2007, 68% of U.S. military personnel injured in the OEF/OIF conflicts had blast-related injuries and 28%-31% of those evacuated to Walter Reed Army Medical Center (WRAMC), Washington, DC had ..
  48. Blood-Brain Barrier Disruption in Blast Neurotrauma
    DESCRIPTION (provided by applicant): Blast-related traumatic brain injury (TBI), the "signature injury" of the Iraq and Afghanistan wars, affects 12- 23% of the 2.2 million U.S. servicemen and women deployed in these conflicts...
  49. Targeting Muller Cells to Treat Optic Nerve Injury
    Sherry Ball; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE Significance of Research: Patients with TBI resulting from blast injury display an array of visual deficits collectively referred to as Post Trauma Vision Syndrome (Padula et al...
  50. The National Neurotrauma Society 30th Annual Conference (Phoenix July 22-25,2012)
    KEVIN KA WANG WANG; Fiscal Year: 2012
    ..On the other hand, during this past year, we continue to see an explosion of interests and publications in blast brain injury (Scheibel, et al., 2011;Bass et a., 2011) which will be featured in the conference...
    ..The development of computerized 3-dimensional (3D) models for electrical arc events and their use in severity rating blast conditions for planning triage and prevention is proposed...
  52. Infant Screening and Diagnosis of Duchenne Muscular Dys*
    Paul Fernhoff; Fiscal Year: 2007
    ..campaign using newspapers, parent magazines, parent websites, Georgia American Academy of Pediatrics (AAP) Blast fax, professional organization newsletters, prenatal classes, and development of parent-targeted posters and ..
  53. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..are numerous where hepatic injury is a vital component of multi-organ failure caused by complex trauma including blast injury, septic shock, and graft failure after liver transplantation often leading to death of the patient...
  54. Cell signaling as a leukemia biomarker
    ..the signal analysis and determine any age or gender effects;2) to measure signaling in 75 MDS and 75 AML patient blast cells to test the hypothesis that signaling can be classified by patterns and determine any age or gender effects;..
  55. Eosinophil ORMDL3 and allergic inflammation
    P Sriramarao; Fiscal Year: 2012
    ..The potential regulation of IL-3-induced ORMDL3 expression via a CD48- mediated pathway will also be investigated...
  56. Using Mass Spectroscopy to Characterize Transcription Proteins and F2-Isoprostane
    BETTYE HENNINTON; Fiscal Year: 2011
    ..Interestingly, a recent Psi-Blast analysis of Gcr1 yielded evidence for a human homolog, MLL3, that is found on a region of chromosome 7 that is ..
  57. Basic Mechanisms in Hearing Loss of Cochlear Origin
    Allen F Ryan; Fiscal Year: 2013
    ..Sensorineural hearing loss (SNHL) is strongly associated with many aspects of military service including blast injury. The objectives of this proposal are to improve the prevention and treatment of SNHL in veterans...
  58. Mechanisms mediating hematopoietic stem and progenitor cell trafficking
    Paul S Frenette; Fiscal Year: 2013
    ..In addition, we have found that these Nestin+ cells are anatomically and functionally associated with CD150+ CD48- Lin- HSCs near blood vessels of the BM...
  59. Immune and genetic determinants of murine glomerulonephritis
    Elahna Paul; Fiscal Year: 2012
    Abstract CD48 is a member of the SLAM/CD2 family of leukocyte cell surface regulatory molecules whose gene is located within the lupus-associated Sle1b region of mouse chromosome 1. C57BL/6 (B6) mice with genetic ablation of CD48 (B6...
  60. Regulation of Hematopoietic Progenitors by de novo DNA Methylation
    Margaret Goodell; Fiscal Year: 2013
    ..MDS is a state of dysregulated hematopoiesis that is characterized by increasing anemia accompanied by high marrow blast counts...
  61. Brain injury due to transcranial versus transthoracic blast exposure
    J Marc Simard; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Blast-induced traumatic brain injury (blast-TBI) is a leading cause of death and disability in soldiers and veterans involved in recent wars in the Middle East, and in civilians exposed to terrorist ..
  62. Role of mesenchymal stem cells in the blood stem cell niche
    Paul S Frenette; Fiscal Year: 2012
    ..Our preliminary data suggest that the vast majority of CD150+CD48- HSCs and SNS-fibers are localized near Nestin+ cells, and that these cells express high levels of key genes ..
  63. Restoring Immune Function Following Radiation Injuries by TLR9 Agonist Treatment
    James A Lederer; Fiscal Year: 2013
    ..The unpredictable nature as well as the complexity of the injuries from a nuclear blast makes this a challenging world health problem...
  64. Src Kinases in Ph+ Lymphoblastic Leukemia
    Shaoguang Li; Fiscal Year: 2009
    ..Gleevec) is highly effective in treating chronic phase CML patients, but is much less effective in treating CML blast crisis and Ph+ B-ALL patients...
  65. Acute Myeloid Leukemia: MRD Analysis Using Modular uFluidics and uFlow Cytometry
    Steven Allan Soper; Fiscal Year: 2013
    ..Following blast release, they will be detected using an impedance sensor to direct them into a containment reservoir possessing a ..
  66. High-Resolution Mapping of Susceptibility Genes for NIHL
    Rick A Friedman; Fiscal Year: 2013 The damage sustained by the cochlea from chronic impulse noise (subsonic) or sudden blast exposure (supersonic) leads to permanent and debilitating hearing loss and tinnitus...
  67. The Osteoblast as a Determinant of Leukemogenesis
    Stavroula Kousteni; Fiscal Year: 2013
    ..More recently, osteoblast precursors have been involved in the fate of another stem cell, the leukemia blast. We have found that an activating mutation in canonical Wnt signaling in osteoblast precursors disrupts ..
  68. Traumatic brain injury: early mechanosensitive events in astrocytes
    ZONGLU S HUA; Fiscal Year: 2013
    Abstract Traumatic brain injury (TBI) is brain damage resulting from an external mechanical force, such as blast or crashes...
  69. Role of CD48:CD244 Pathway in Systemic Lupus Erythematosus
    DANIEL RABIN BROWN; Fiscal Year: 2013
    ..applicant): Project Summary The main goal of this K08 Award is to investigate the roles of the SLAM family members CD48 and CD244 in murine and human Systemic Lupus Erythematosus (SLE). The K08 Award will be mentored by Dr...
  70. Role of Redox Dependent Signaling in Leukemia
    Joya Chandra; Fiscal Year: 2010 imatinib mesylate, have dramatically altered the treatment of chronic phase disease, but are less effective in blast crisis and against specific point mutations in BCR/ABL...
  71. Evaluation of Approaches to Auditory Rehabilitation for Mild TBI
    Gabrielle Saunders; Fiscal Year: 2009
    ..Many are veterans of the OIF/OEF conflicts who have been exposed to blast - the most common wounding etiology in these conflicts...
    Kathleen Kreiss; Fiscal Year: 1991
    ..Persons with beryllium disease have cell-mediated immune responses to beryllium, detected by beryllium-specific blast transformation of lung lymphocytes obtained through bronchoalveolar lavage...
  73. STAT Palm-Sized Blood Counter
    EUGENE YAN HO CHAN; Fiscal Year: 2010
    ..For instance, a rapidly rising white blood cell count may occur during infections or leukemic blast crises. Hematocrit values may rapidly decline in traumas, gastrointestinal bleeds, and post-procedure recoveries...
  74. HIV Evasion of NK Cells in Lymph Nodes
    Allan R Tenorio; Fiscal Year: 2010
    ..e., CD48 and NTB-A) while maintaining the expression of inhibitory molecules (i.e., HLA-C)...
  75. Targeting protein synthesis in AML
    ARTHUR FRANKEL; Fiscal Year: 2006
    ..These molecules consist of the catalytic and translocation domains of diphtheria toxin (DT388) fused to leukemic blast selective ligands...
  76. Urological Studies of Ideopathic Lower Tract Syndrome
    JOHN KRIEGER; Fiscal Year: 2005
    ..Sequences will be compared to available databases using BLAST searches and phylogeny software...
  77. Anthrax spore-surface antigens for biosensor development
    Manohar John; Fiscal Year: 2004
    ..Genes isolated using this combination strategy, will then be identified by a BLAST search against sequences contained in the National Center for Biotechnology Information (NCBI) non-redundant ..