CD46

Summary

Gene Symbol: CD46
Description: CD46 molecule
Alias: AHUS2, MCP, MIC10, TLX, TRA2.10, membrane cofactor protein, CD46 antigen, complement regulatory protein, CD46 molecule, complement regulatory protein, antigen identified by monoclonal antibody TRA-2-10, complement membrane cofactor protein, measles virus receptor, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), trophoblast leucocyte common antigen, trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen
Species: human

Top Publications

  1. ncbi The human CD46 molecule is a receptor for measles virus (Edmonston strain)
    R E Dörig
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    Cell 75:295-305. 1993
  2. ncbi Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria
    H Källström
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    Mol Microbiol 25:639-47. 1997
  3. ncbi Genetic studies into inherited and sporadic hemolytic uremic syndrome
    P Warwicker
    Department of Medicine, University of Newcastle upon Tyne, England, United Kingdom
    Kidney Int 53:836-44. 1998
  4. ncbi CD46 is a cellular receptor for human herpesvirus 6
    F Santoro
    Unit of Human Virology, DIBIT, San Raffaele Scientific Institute, Milano, Italy
    Cell 99:817-27. 1999
  5. ncbi Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation
    G Wang
    Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 164:1839-46. 2000
  6. ncbi MCP-1 promoter polymorphism in Spanish patients with systemic lupus erythematosus
    F Aguilar
    Servicio de Inmunologia, Hospital Universitario Virgen del Rocio, Servicio Andaluz de Salud, Sevilla, Spain
    Tissue Antigens 58:335-8. 2001
  7. ncbi Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF
    Mitsue Kurita-Taniguchi
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka, Japan
    Mol Immunol 38:689-700. 2002
  8. pmc Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes
    Olga Barreiro
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
    J Cell Biol 157:1233-45. 2002
  9. pmc The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3
    Dominique Sirena
    Institute of Molecular Biology, University of Zurich, CH 8057 Zurich, Switzerland
    J Virol 78:4454-62. 2004
  10. pmc CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7
    Marko Marttila
    Department of Virology, Umea University, SE 901 85 Umea, Sweden
    J Virol 79:14429-36. 2005

Research Grants

  1. Val S Goodfellow; Fiscal Year: 2014
  2. Lipoprotein Receptors and Inflammation in the Vessel Wall
    Dudley K Strickland; Fiscal Year: 2011
  3. The Role of Microglia in Prolonged Anxiety-like Behavior following Social Stress
    Eric S Wohleb; Fiscal Year: 2013
  4. Ronald G Collman; Fiscal Year: 2015
  5. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
  6. Elizabeth J Kovacs; Fiscal Year: 2016
  7. Molecular Mechanisms of Genistein in the Prevention of Inflammatory Cytokine (TNF
    Zhenquan Jia; Fiscal Year: 2010
  8. 3D Culture of Adipose Tissue for Screening Obesity-related Drugs
    Kacey G Marra; Fiscal Year: 2012
  9. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
  10. T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced Obesity
    CHRISTIE MITCHELL BALLANTYNE; Fiscal Year: 2013

Patents

  1. CD46 VARIANTS

Detail Information

Publications408 found, 100 shown here

  1. ncbi The human CD46 molecule is a receptor for measles virus (Edmonston strain)
    R E Dörig
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec
    Cell 75:295-305. 1993
    ..A study of lymphocyte markers suggested that the complement regulator known either as membrane cofactor protein or CD46 was the measles virus receptor...
  2. ncbi Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria
    H Källström
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    Mol Microbiol 25:639-47. 1997
    ..This is a migration pattern typical of membrane cofactor protein (MCP or CD46). MCP is a widely distributed human complement regulatory protein...
  3. ncbi Genetic studies into inherited and sporadic hemolytic uremic syndrome
    P Warwicker
    Department of Medicine, University of Newcastle upon Tyne, England, United Kingdom
    Kidney Int 53:836-44. 1998
    ..In light of these findings and previous reports of HUS in patients with factor H deficiency, we postulate that abnormalities of factor H may be involved in the etiology of HUS...
  4. ncbi CD46 is a cellular receptor for human herpesvirus 6
    F Santoro
    Unit of Human Virology, DIBIT, San Raffaele Scientific Institute, Milano, Italy
    Cell 99:817-27. 1999
    ..Here, we show that the two major HHV-6 subgroups (A and B) use human CD46 as a cellular receptor. Downregulation of surface CD46 was documented during the course of HHV-6 infection...
  5. ncbi Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation
    G Wang
    Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 164:1839-46. 2000
    b>Membrane cofactor protein (MCP; CD46) is a widely expressed type 1 transmembrane glycoprotein that inhibits complement activation on host cells...
  6. ncbi MCP-1 promoter polymorphism in Spanish patients with systemic lupus erythematosus
    F Aguilar
    Servicio de Inmunologia, Hospital Universitario Virgen del Rocio, Servicio Andaluz de Salud, Sevilla, Spain
    Tissue Antigens 58:335-8. 2001
    ..role of the functional polymorphism located in the regulatory region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to systemic lupus erythematosus (SLE) was investigated...
  7. ncbi Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF
    Mitsue Kurita-Taniguchi
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka, Japan
    Mol Immunol 38:689-700. 2002
    Human CD46, formerly membrane cofactor protein (MCP), binds and inactivates complement C3b and serves as a receptor for measles virus (MV), thereby protecting cells from homologous complement and sustaining systemic viral infection...
  8. pmc Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes
    Olga Barreiro
    Servicio de Inmunologia, Hospital de la Princesa, Universidad Autonoma de Madrid, 28006 Madrid, Spain
    J Cell Biol 157:1233-45. 2002
    ..These results provide the first characterization of an endothelial docking structure that plays a key role in the firm adhesion of leukocytes to the endothelium during inflammation...
  9. pmc The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3
    Dominique Sirena
    Institute of Molecular Biology, University of Zurich, CH 8057 Zurich, Switzerland
    J Virol 78:4454-62. 2004
    ..Using Sindbis virus-mediated cDNA library expression, we identify here the membrane cofactor protein CD46 as a surface receptor of species B Ad3...
  10. pmc CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7
    Marko Marttila
    Department of Virology, Umea University, SE 901 85 Umea, Sweden
    J Virol 79:14429-36. 2005
    ..We have previously demonstrated that adenovirus type 11 (species B) uses CD46 (membrane cofactor protein) as a cellular receptor instead of the coxsackie-adenovirus receptor (A. Segerman et al., J. Virol...
  11. ncbi Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor
    Christoph Fleischli
    Institute of Molecular Biology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Gen Virol 88:2925-34. 2007
    We recently characterized the domains of the human cofactor protein CD46 involved in binding species B2 adenovirus (Ad) serotype 35...
  12. pmc Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype
    T W Post
    Department of Medicine, Washington, University School of Medicine, St Louis, Missouri 63110
    J Exp Med 174:93-102. 1991
    b>Membrane cofactor protein (MCP) is a complement regulatory protein that is expressed on human cells and cell lines as two relatively broad species with Mr of 58,000-68,000 and 48,000-56,000...
  13. ncbi Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation
    A Astier
    Institut National de la Santé et de la Recherche Médicale Unité 503, Ecole Normale Superieure de Lyon, France
    J Immunol 164:6091-5. 2000
    The widely expressed transmembrane molecule CD46 is the complement regulatory receptor for C3b as well as the receptor for several pathogens. Beside its binding functions, CD46 is also able to transduce signals...
  14. ncbi A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization
    Mandy J Ludford-Menting
    Peter MacCallum Cancer Institute, Trescowthick Research Laboratories, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    J Biol Chem 277:4477-84. 2002
    Using a yeast two-hybrid screen, we identified a physical interaction between CD46 and DLG4. CD46 is a ubiquitous human cell-surface receptor for the complement components C3b and C4b and for measles virus and human herpesvirus 6...
  15. ncbi CD46/CD3 costimulation induces morphological changes of human T cells and activation of Vav, Rac, and extracellular signal-regulated kinase mitogen-activated protein kinase
    Y Zaffran
    Institut National de la Santé et de la Recherche Médicale Unité 503, Centre Européen de Recherche en Virologie et Immunologie, Lyon, France
    J Immunol 167:6780-5. 2001
    ..We recently showed that CD46, a complement regulatory receptor for C3b as well as a receptor for several pathogens, could act as a potent ..
  16. pmc CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae
    Shaun W Lee
    Department of Molecular Microbiology and Immunology, L220, Oregon Health and Science University, Portland, OR 97201
    J Cell Biol 156:951-7. 2002
    The Neisseria type IV pilus promotes bacterial adhesion to host cells. The pilus binds CD46, a complement-regulatory glycoprotein present on nucleated human cells (Källström et al., 1997)...
  17. pmc Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46
    Yasuko Mori
    Department of Microbiology, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Virol 76:6750-61. 2002
    ..Furthermore, the fusion event was dependent on the expression of the HHV-6 entry receptor, CD46, on the target cell membrane...
  18. ncbi Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells
    Maria L Barilla-LaBarca
    Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 168:6298-304. 2002
    C4b and C3b deposited on host cells undergo limited proteolytic cleavage by regulatory proteins. Membrane cofactor protein (MCP; CD46), factor H, and C4b binding protein mediate this reaction, known as cofactor activity, that also ..
  19. ncbi Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation
    Julien C Marie
    INSERM U404, Immunité et Vaccination, CERVI, 21 Avenue Tony Garnier, 69365 Lyon, Cedex 07, France
    Nat Immunol 3:659-66. 2002
    b>CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products...
  20. ncbi Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa
    Rebecca C Riley
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Reprod Dev 62:534-46. 2002
    b>Membrane cofactor protein (MCP; CD46) is a complement regulator widely expressed as four isoforms that arise via alternative splicing...
  21. ncbi CD46 in meningococcal disease
    Linda Johansson
    Microbiology and Tumor Biology Center, Nobels vag 16, Box 280, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Science 301:373-5. 2003
    ..The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation...
  22. ncbi Ligand binding determines whether CD46 is internalized by clathrin-coated pits or macropinocytosis
    Blessing Crimeen-Irwin
    Peter MacCallum Cancer Centre, Trescowthick Research Laboratories, St Andrew s Place, East Melbourne, Victoria 3002, Australia
    J Biol Chem 278:46927-37. 2003
    b>CD46 is a ubiquitous human cell surface receptor for the complement components C3b and C4b and for various pathogens, including the measles virus and human herpes virus 6...
  23. pmc Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome
    Anna Richards
    Institute of Human Genetics, University of Newcastle upon Tyne, Newcastle NE1 4LP, United Kingdom
    Proc Natl Acad Sci U S A 100:12966-71. 2003
    b>Membrane cofactor protein (MCP; CD46) is a widely expressed transmembrane complement regulator. Like factor H it inhibits complement activation by regulating C3b deposition on targets...
  24. ncbi Familial haemolytic uraemic syndrome and an MCP mutation
    Marina Noris
    Mario Negri Institute for Pharmacological Research, Clinical Research Center for Rare Diseases, Aldo e Cele Daccò, Villa Camozzi Ranica, Bergamo, Italy
    Lancet 362:1542-7. 2003
    ..However, most patients with D-HUS have no HF1 mutations, despite decreased serum concentrations of C3. Our aim, therefore, was to assess whether genetic abnormalities in other complement regulatory proteins are involved...
  25. pmc Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation
    Jane Oliaro
    Immune Signalling Laboratory, Peter MacCallum Cancer Centre, Faculty of Medicine, University of Melbourne, St Andrew s Place, East Melbourne, VIC 3010, Australia
    Proc Natl Acad Sci U S A 103:18685-90. 2006
    ..We investigated the effect of ligation of the immunoregulatory cell surface receptor, CD46, on lymphocyte polarity during antigen presentation and cytotoxic effector function...
  26. pmc Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome
    Celia J Fang
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 111:624-32. 2008
    ..Genetic studies demonstrate that heterozygous mutations of membrane cofactor protein (MCP;CD46) predispose to atypical HUS (aHUS), which is not associated with exposure to Shiga toxin (Stx)...
  27. doi Inherited deficiency of membrane cofactor protein expression and varying manifestations of recurrent atypical hemolytic uremic syndrome in a sibling pair
    Lionel Couzi
    CHU Bordeaux, Hopital Pellegrin, Bordeaux, France
    Am J Kidney Dis 52:e5-9. 2008
    ..Complement factor H (CFH), factor I, and membrane cofactor protein (MCP; CD46), 3 regulators of the alternative pathway of the complement system activation, have been ..
  28. doi Restriction analysis of otosclerosis-associated CD46 splicing variants
    Péter Csomor
    Department of Otolaryngology Head and Neck Surgery, University of Debrecen Medical and Health Science Center, Nagyerdei krt 98, Debrecen, 4032, Hungary
    Eur Arch Otorhinolaryngol 267:219-26. 2010
    ..The human cellular receptor of measles virus is the membrane cofactor protein (MCP, CD46), which has 14 well-described splicing variants...
  29. pmc Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome
    Iain Moore
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Blood 115:379-87. 2010
    ..In 5 patients mutations were identified: 1 in CFH, 1 in CFI, 1 in CD46, and 2 in C3...
  30. pmc Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection
    Nathan J Weyand
    BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA
    J Immunol 184:694-701. 2010
    b>CD46 is a type I transmembrane protein with complement and T cell regulatory functions in human cells...
  31. pmc The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation
    Siobhan Ni Choileain
    Institute of Immunology and Infection Research, Edinburgh, United Kingdom
    PLoS ONE 6:e16287. 2011
    Adequate termination of an immune response is as important as the induction of an appropriate response. CD46, a regulator of complement activity, promotes T cell activation and differentiation towards a regulatory Tr1 phenotype...
  32. pmc Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins
    D M Lublin
    Department of Pathology, Washington University, St Louis, Missouri 63110
    J Exp Med 168:181-94. 1988
    b>Membrane cofactor protein (MCP), a regulatory molecular of the complement system with cofactor activity for the factor I-mediated inactivation of C3b and C4b, is widely distributed, being present on leukocytes, platelets, endothelial ..
  33. pmc Membrane cofactor protein (CD46) is a keratinocyte receptor for the M protein of the group A streptococcus
    N Okada
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Proc Natl Acad Sci U S A 92:2489-93. 1995
    ..b>Membrane cofactor protein (MCP), or CD46, is a short consensus repeat-containing protein found on the surface of keratinocytes, ..
  34. pmc Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus
    D Naniche
    CNRS ENS Lyon UMR 49, France
    J Virol 67:6025-32. 1993
    ..glycoprotein (gp57/67) was immunopurified, and N-terminal amino acid sequencing identified it as human membrane cofactor protein (CD46), a member of the regulators of complement activation gene cluster...
  35. pmc Crystal structure of two CD46 domains reveals an extended measles virus-binding surface
    J M Casasnovas
    Department of Biosciences at Novum, Karolinska Institute, 14157 Huddinge, Sweden
    EMBO J 18:2911-22. 1999
    ..The cell surface receptor for measles virus in humans is CD46, a complement cofactor. We report here the crystal structure at 3...
  36. ncbi Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence
    H Källström
    Microbiology and Tumorbiology Centre, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Cell Microbiol 3:133-43. 2001
    Pili of Neisseria gonorrhoeae mediate binding of the bacteria to human host cells. Membrane cofactor protein (MCP or CD46), a human cell-surface protein involved in regulation of complement activation, acts as a cellular pilus receptor...
  37. ncbi Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
    Claudia Kemper
    Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 421:388-92. 2003
    ..Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4+ T cells...
  38. pmc Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome
    Jessica Caprioli
    Mario Negri Institute for Pharmacologic Research, Clinical Research Center for Rare Diseases, Aldo e Cele Daccò, Bergamo, Italy
    Blood 108:1267-79. 2006
    ..We undertook genetic analysis on membrane cofactor protein (MCP), complement factor H (CFH), and factor I (IF) in 156 patients with non-Stx-HUS...
  39. ncbi ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells
    Juha Hakulinen
    Department of Pathology, Haartman Institute and Biomedicum Helsinki, University of Helsinki and Helsinki University Hospital, Finland
    J Biol Chem 281:21369-76. 2006
    b>Membrane cofactor protein CD46 controls complement activation on cells, is a receptor for several pathogens, and modulates immune responses by affecting CD8(+) T cells...
  40. ncbi Cutting edge: abortive proliferation of CD46-induced Tr1-like cells due to a defective Akt/Survivin signaling pathway
    Gregory Meiffren
    Institut National de la Santé et de la Recherche Médicale Unité 503 IFR 128 BioSciences Lyon Gerland Université Claude Bernard Lyon 1, Lyon, France
    J Immunol 177:4957-61. 2006
    T regulatory cell 1 (Tr1) are low proliferating peripherally induced suppressive T cells. Engaging CD3 and CD46 on human CD4+ T cells induces a Tr1-like phenotype...
  41. pmc CD46-induced immunomodulatory CD4+ T cells express the adhesion molecule and chemokine receptor pattern of intestinal T cells
    Shannon K Alford
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:2544-55. 2008
    ..Activation of human primary CD4(+) T cells in the presence of CD46 cross-linking induces the development of a distinct immunomodulatory T cell population characterized by high IL-10/..
  42. pmc CD46-induced human Treg enhance B-cell responses
    Anja Fuchs
    Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, MO, USA
    Eur J Immunol 39:3097-109. 2009
    ..be induced by the concomitant stimulation of human CD4(+) T cells through CD3 and the membrane complement regulator CD46. These complement (CD46)-induced regulatory T cells (cTreg) potently inhibit bystander T-cell proliferation through ..
  43. doi Autophagy induction by the pathogen receptor CD46
    Pierre Emmanuel Joubert
    Universite de Lyon, Lyon, F 69003, France
    Cell Host Microbe 6:354-66. 2009
    ..We report here that the engagement of CD46, a ubiquitous human surface receptor able to bind several different pathogens, is sufficient to induce autophagy...
  44. pmc The development of atypical haemolytic-uraemic syndrome is influenced by susceptibility factors in factor H and membrane cofactor protein: evidence from two independent cohorts
    V Fremeaux-Bacchi
    Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, Paris, France
    J Med Genet 42:852-6. 2005
    ..have been reported in regulators of the alternative complement pathway including factor H (CFH), membrane cofactor protein (MCP), and the serine protease factor I (IF)...
  45. pmc Integrating host genomics with surveillance for invasive bacterial diseases
    Dana C Crawford
    Vanderbilt University, Nashville, Tennessee, USA
    Emerg Infect Dis 14:1138-40. 2008
    ..Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to ..
  46. pmc Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46)
    M Manchester
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 92:2303-7. 1995
    The human complement regulatory protein membrane cofactor protein (CD46) is the cellular receptor for measles virus (MV), whereas decay accelerating factor (DAF; CD55), a structurally similar complement regulatory protein, does not bind ..
  47. pmc The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells
    H Tanaka
    Pharmaceutical Discovery Research Laboratories, Teijin Institute for Biomedical Research, Tokyo, Japan
    Br J Pharmacol 116:2298-302. 1995
    ..of various prostaglandins (PGs) to inhibit monocyte chemotaxis induced by monocyte chemoattractant protein-1 (MCP-1) was investigated with a human monocytic leukaemia cell line, THP-1...
  48. ncbi The sagittal band: anatomic and biomechanical study
    C M Young
    Hand Surgery Section, Orthopedic Surgery Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    J Hand Surg Am 25:1107-13. 2000
    ..The SB was observed to be part of a complex retinacular system in proximity to the metacarpophalangeal (MCP) joint collateral ligaments and the palmar plate...
  49. ncbi Effects of finger posture on carpal tunnel pressure during wrist motion
    P J Keir
    Division of Occupational Medicine, Department of Medicine, University of California, San Francisco, USA
    J Hand Surg Am 23:1004-9. 1998
    ..Range of motion tasks of wrist flexion-extension and radioulnar deviation were repeated with metacarpophalangeal (MCP) joint angles of 0 degrees, 45 degrees, and 90 degrees flexion...
  50. ncbi Alizapride alone or alizapride-dexamethasone compared with metoclopramide-dexamethasone in patients at high risk of acute emesis after cisplatin. A randomized cross-over study
    C F Pollera
    Division of Medical Oncology I, Regina Elena Institute for Cancer Research, Rome, Italy
    Acta Oncol 30:725-9. 1991
    ..or in combination with dexamethasone (DXM, 40 mg) was compared to a combination of DXM (40 mg) and metoclopramide (MCP, 4 mg/kg) in a randomized cross-over trial conducted on 21 out-patients at high emetic risk after moderate-dose ..
  51. ncbi Enzyme injection as nonsurgical treatment of Dupuytren's disease
    M A Badalamente
    Department of Orthopaedics, State University of New York at Stony Brook, Health Science Center, Stony Brook, NY, USA
    J Hand Surg Am 25:629-36. 2000
    ..4,800, and 9,600 U collagenase injected into the cord that was causing contracture of the metacarpophalangeal (MCP) joint. There were no beneficial clinical effects of these injections...
  52. ncbi An immunohistochemical study of the distribution of the measles virus receptors, CD46 and SLAM, in normal human tissues and subacute sclerosing panencephalitis
    Stephen McQuaid
    Neuropathology Laboratory, Royal Victoria Hospital, Queen s University Belfast, Northern Ireland
    Lab Invest 82:403-9. 2002
    We have compared the expression of the known measles virus (MV) receptors, membrane cofactor protein (CD46) and the signaling lymphocyte-activation molecule (SLAM), using immunohistochemistry, in a range of normal peripheral tissues (..
  53. ncbi Cilostazol, a cAMP phosphodiesterase inhibitor, attenuates the production of monocyte chemoattractant protein-1 in response to tumor necrosis factor-alpha in vascular endothelial cells
    Y Nishio
    Third Department of Medicine, Shiga University of Medical Science, Japan
    Horm Metab Res 29:491-5. 1997
    The induction of monocyte chemoattractant protein-1 (MCP-1) in vascular endothelial cells is thought to be an initial event in the development of atherosclerotic lesions...
  54. ncbi The effect of thumb metacarpophalangeal ulnar collateral ligament attachment site on joint range of motion: an in vitro study
    C H Bean
    Harborview Medical Center, Department of Orthopedics, University of Washington, Seattle 98104, USA
    J Hand Surg Am 24:283-7. 1999
    Although reconstruction of the torn thumb metacarpophalangeal (MCP) joint ulnar collateral ligament (UCL) has been shown to reduce symptoms, final joint motion may be different from that of the uninjured state...
  55. ncbi Glomerular expression of C-C chemokines in different types of human crescentic glomerulonephritis
    Zhi Hong Liu
    Research Institute of Nephrology, Nanjing University School of Medicine, Jinling Hospital, Nanjing, PR China
    Nephrol Dial Transplant 18:1526-34. 2003
    ..C-C chemokines, monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha and beta (MIP-1alpha and MIP-1beta), are major chemoattractants for ..
  56. ncbi Peripheral median nerve block impairs precision pinch movement
    Zong Ming Li
    Hand Research Laboratory, Departments of Orthopaedic Surgery and Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Clin Neurophysiol 117:1941-8. 2006
    ..The objective of this study was to investigate the effects of a simulated peripheral median nerve lesion on precision pinch movement by the thumb and index finger...
  57. ncbi Effects of metoclopramide on the growth hormone response to galanin in normal man
    A Giustina
    Cattedra di Clinica Medica, University of Brescia, Italy
    Horm Metab Res 25:489-92. 1993
    ..via dopaminergic pathways evaluating the effects of a potent central dopaminergic receptor blocker, metoclopramide (MCP), on the galanin-induced growth hormone (GH) secretion in normal subjects...
  58. ncbi Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo
    G Angus McQuibban
    Department of Biochemistry and Molecular Biology and the Biomedical Research Centre, University of British Columbia, Vancouver, Canada
    Blood 100:1160-7. 2002
    Monocyte chemoattractant protein (MCP)-3 is inactivated upon cleavage by the matrix metalloproteinase (MMP) gelatinase A (MMP-2)...
  59. pmc Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis
    Cheng Zhang
    Department of General Surgery, 201 Hospital of Chinese PLA, Liaoyang 111000, Liaoning Province, China
    World J Gastroenterol 11:6770-4. 2005
    ..To investigate the effect of IL-4 on the altered expression of complement activation regulators in pancreas and pancreatic necrosis during experimental severe acute pancreatitis (SAP)...
  60. ncbi The CC chemokine antagonist Met-RANTES inhibits eosinophil effector functions through the chemokine receptors CCR1 and CCR3
    J Elsner
    Hannover Medical School, Department of Dermatology, Germany
    Eur J Immunol 27:2892-8. 1997
    ..Met-RANTES, on human eosinophil effector functions in response to RANTES, monocyte chemoattractant protein (MCP)-3 and eotaxin...
  61. ncbi 5-HT1-, but not 5-HT2-serotonergic, M1-, M2-muscarinic cholinergic or dopaminergic receptors mediate the ACTH/cortisol response to metoclopramide in man
    V Coiro
    University Clinic of Internal Medicine, School of Medicine, University of Parma, Italy
    Horm Res 33:233-8. 1990
    ..muscarinic cholinergic and/or serotonergic receptors in the response of ACTH/cortisol to metoclopramide (MCP) was evaluated in 27 normal men...
  62. ncbi Long-term results of cemented Steffee arthroplasty of the thumb metacarpophalangeal joint
    R M McGovern
    Department of Orthopaedic Surgery, Division of Hand and Microsurgery, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    J Hand Surg Am 26:115-22. 2001
    A retrospective evaluation of the Steffee metacarpophalangeal (MCP) thumb joint prostheses was performed to determine the long-term outcome and survivorship of the prosthesis...
  63. pmc Chemokines in the limbal form of vernal keratoconjunctivitis
    A M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Br J Ophthalmol 84:1360-6. 2000
    ..this study were to investigate the expression of the CC chemokines, RANTES, eotaxin, monocyte chemotactic protein (MCP) 1, MCP-2, and MCP-3 in the conjunctiva of patients with vernal keratoconjunctivitis (VKC) and to determine the ..
  64. ncbi Shiga toxin-2 triggers endothelial leukocyte adhesion and transmigration via NF-kappaB dependent up-regulation of IL-8 and MCP-1
    Carla Zoja
    Mario Negri Institute for Pharmacological Research, Azienda Ospedaliera, Ospedali Riuniti di Bergamo, Via Gavazzeni 11, 24125 Bergamo, Italy
    Kidney Int 62:846-56. 2002
    ..cells under flow; (2) the effect of Stx-2 on endothelial expression of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) and their functional role in the adhesive phenomena; and (3) the role of nuclear factor-..
  65. ncbi Passive axial rotation of the metacarpophalangeal joint
    J Krishnan
    Orthopaedic Department, Repatriation General Hospital, Daw Park, Australia
    J Hand Surg Br 22:270-3. 1997
    We measured passive axial rotation at the metacarpophalangeal (MCP) joints of the index, long, ring and small fingers of both hands in 100 healthy subjects using a magnetic position and orientation system called an Isotrak...
  66. ncbi Circulating levels of ICAM-1, VCAM-1, and MCP-1 are increased in haemodialysis patients: association with inflammation, dyslipidaemia, and vascular events
    Aikaterini Papayianni
    Department of Nephrology, Hippokration General Hospital, Thessaloniki, Greece
    Nephrol Dial Transplant 17:435-41. 2002
    ....
  67. ncbi Analysis of intrinsic-extrinsic muscle function through interactive 3-dimensional kinematic simulation and cadaver studies
    William L Buford
    Department of Orthopaedics and Rehabilitation, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Hand Surg Am 30:1267-75. 2005
    ..of intrinsic muscle function and its relationship to the overall flexion moment at the index metacarpophalangeal (MCP) joint. Prior studies reported inconsistent levels of intrinsic contribution varying from 12...
  68. doi Effects of monocrotophos on the reproductive axis in the male goldfish (Carassius auratus): potential mechanisms underlying vitellogenin induction
    Hua Tian
    Marine Life Science College, Ocean University of China, 5 Yushan Road, Qingdao 266003, Shandong Province, PR China
    Aquat Toxicol 98:67-73. 2010
    Monocrotophos (MCP) is a highly toxic organophosphorus pesticide that has been banned in many countries...
  69. ncbi Reliability and sensitivity to change of various measures of hand function in relation to treatment of synovitis of the metacarpophalangeal joint in rheumatoid arthritis
    P H Goossens
    Department of Rheumatology and. Medical Statistics, Leiden University Medical Centre, The Netherlands
    Rheumatology (Oxford) 39:909-13. 2000
    ..in order to obtain tests suitable for the evaluation of local treatment of an arthritic metacarpophalangeal (MCP) joint...
  70. ncbi Human T-cell leukemia virus type I tax activates transcription of the human monocyte chemoattractant protein-1 gene through two nuclear factor-kappaB sites
    N Mori
    Department of Preventive Medicine and AIDS Research, Institute of Tropical Medicine, Nagasaki University, Japan
    Cancer Res 60:4939-45. 2000
    ..One such chemokine is monocyte chemoattractant protein (MCP)-1, a member of the C-C subfamily of chemokines...
  71. ncbi Muscarinic cholinergic, but not serotoninergic mediation of arginine vasopressin response to metoclopramide in man
    V Coiro
    Cattedra di Clinica Medica Generale, Universita di Parma, Italy
    Clin Endocrinol (Oxf) 31:491-8. 1989
    The possibility that metoclopramide (MCP) stimulates arginine vasopressin (AVP) secretion in man through a serotoninergic and/or a cholinergic muscarinic pathway was studied...
  72. ncbi Monocyte chemotactic protein-1 is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intra-amniotic infection
    M Sean Esplin
    Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    J Matern Fetal Neonatal Med 17:365-73. 2005
    Pro-inflammatory chemokines have been associated with preterm parturition. Monocyte chemotactic protein-1 (MCP-1) is a chemokine capable of recruiting monocytes/macrophages into sites of inflammation, as well as stimulating the ..
  73. pmc Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes
    Jelena Mojsilovic-Petrovic
    Neurobiology Program, Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
    J Neuroinflammation 4:12. 2007
    ..In this study, we demonstrate the role of HIF-1alpha in hypoxia-induced up-regulation of inflammatory chemokines, human monocyte chemoattractant protein-1 (MCP-1/CCL2) and mouse MCP-5 (Ccl12), in human and mouse astrocytes, respectively.
  74. ncbi Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome
    Anna Richards
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, Campus Box 8045, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Immunol 44:111-22. 2007
    ..Mutations in membrane cofactor protein (MCP; CD46) that predispose to the development of aHUS were first identified in 2003...
  75. ncbi [Effect of ginsenoside Rgl on the expression of TNF-alpha and MCP-1 in rats with diabetic nephropathy]
    Li Na Zhang
    Department of Nephrology, State Key Laboratory of Biotherapy of Human Disease, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:466-71. 2009
    To investigate the effects of Ginsenoside Rgl on proteinuria and the expression of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in rats with diabetic nephropathy (DN).
  76. doi MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP
    Craig W Younce
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA
    Biochem J 426:43-53. 2010
    b>MCP-1 (monocyte chemotactic protein-1) plays a critical role in the development of heart failure that is known to involve apoptosis. How MCP-1 contributes to cell death involved in the development of heart disease is not understood...
  77. ncbi Three-dimensional metacarpophalangeal joint kinematics using two markers on the phalanx
    A D Speirs
    Department of Mechanical Engineering, Queen s University, Kingston, Ontario, Canada
    Proc Inst Mech Eng H 215:415-9. 2001
    A protocol for analysing three-dimensional metacarpophalangeal (MCP) joint motion in vivo using two markers on the proximal phalanx is described...
  78. ncbi The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated by the liver growth agents, phenobarbital and methylclofenapate
    N J Plant
    School of Biological Sciences, Molecular Toxicology Division, University of Nottingham, University Park, UK
    Carcinogenesis 19:1521-7. 1998
    ..system which supports high level induction of DNA synthesis by the peroxisome proliferator, methylclofenapate (MCP) (Plant, N.J. et al., 1998, Carcinogenesis, 19, 925-931)...
  79. ncbi The cardiovascular effects of metoclopramide in multiple system atrophy and pure autonomic failure
    F Magnifico
    Institute of Neurology, University of Bologna, Italy
    Clin Auton Res 11:163-8. 2001
    Metoclopramide (MCP), a central and peripheral dopaminergic blocker with cholinergic activity, has been proposed to treat orthostatic hypotension (OH) on the basis that it could antagonize the vasodilator and natriuretic effects of ..
  80. ncbi Antiemetic efficacy of ondansetron and metoclopramide, both combined with corticosteroid, in malignant lymphoma patients receiving non-cisplatin chemotherapy
    M Jørgensen
    Department of Internal Medicine, Copenhagen County Hospital Herlev, Denmark
    Acta Oncol 35:159-63. 1996
    The aim of the present study was to compare the antiemetic efficacy of ondansetron (OND) with metoclopramide (MCP), both combined with corticosteroid (CS) in patients with malignant lymphoma...
  81. ncbi CC chemokine concentrations increase in respiratory distress syndrome and correlate with development of bronchopulmonary dysplasia
    R John Baier
    Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
    Pediatr Pulmonol 37:137-48. 2004
    ..Tracheal aspirate concentrations of monocyte chemoattractant proteins-1,2,3 (MCP-1,2,3) and macrophage inflammatory proteins-1alpha and -1beta (MIP-1alpha, MIP-1beta) were determined by enzyme-..
  82. ncbi Metacarpophalangeal joint prostheses: a review of past and current designs
    D J Beevers
    Rheumatology and Rehabilitation Research Unit, University of Leeds
    Proc Inst Mech Eng H 207:195-206. 1993
    The anatomy and biomechanics of the metacarpophalangeal (MCP) joint are briefly described...
  83. ncbi Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics
    S Ying
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Immunol 163:6321-9. 1999
    ..We examined the expression of eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), MCP-4, and CCR3 in the bronchial mucosa from atopic (AA) and nonatopic (intrinsic; NAA) asthmatics and compared ..
  84. ncbi Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification
    Nozomu Murabayashi
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    Microbes Infect 4:785-94. 2002
    Human CD46 (membrane cofactor protein, or MCP) and CDw150 (signaling lymphocyte activation molecule, or SLAM) serve as receptors for measles virus (MV), which induces marked host immune suppression...
  85. ncbi Thumb reconstruction with a wraparound free flap according to the level of amputation
    K S Lee
    Department of Orthopaedic Surgery, College of Medicine, Korea University, Seoul, Korea
    J Hand Surg Am 25:644-50. 2000
    We surgically treated 37 thumbs amputated distal or proximal to the metacarpophalangeal (MCP) joint using a wraparound free flap from the great toe for the reconstruction...
  86. doi A randomised controlled equivalence trial to determine the effectiveness and cost-utility of manual chest physiotherapy techniques in the management of exacerbations of chronic obstructive pulmonary disease (MATREX)
    J Cross
    School of Allied Health Professions, University of East Anglia, Norwich, UK
    Health Technol Assess 14:1-147, iii-iv. 2010
    To estimate the effect, if any, of manual chest physiotherapy (MCP) administered to patients hospitalised with chronic obstructive pulmonary disease (COPD) exacerbation on both disease-specific and generic health-related quality of life...
  87. ncbi Sodium homeostasis and hormonal responses during dopaminergic blockade in normal humans
    P Coruzzi
    Institute of Semeiotica Medica, University of Parma, Italy
    Am J Hypertens 3:87S-89S. 1990
    ..to 2 h water immersion (WI) with and without pharmacological dopaminergic (DA) blockade with metoclopramide (MCP). Urinary sodium excretion showed a marked increase during WI alone while it was blunted during WI plus DA blockade...
  88. ncbi Parenteral iron treatment induces MCP-1 accumulation in plasma, normal kidneys, and in experimental nephropathy
    Richard A Zager
    Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    Kidney Int 68:1533-42. 2005
    Monocyte chemoattractant protein-1 (MCP-1) promotes renal inflammation, thereby contributing to acute and chronic nephropathies. Its production is stimulated by oxidative stress...
  89. ncbi Immunohistochemical study of monocyte chemoattractant protein-1 in the pancreas of NOD mice following cyclophosphamide administration and during spontaneous diabetes
    Yan Bai
    School of Biological Sciences, University of Auckland, Private Bag, 92019, Auckland, New Zealand
    J Mol Histol 37:101-13. 2006
    ..The chemokine, monocyte chemoattractant protein-1 (MCP-1), previously shown to be important in leukocyte trafficking in other disease systems, may be a key participant in ..
  90. ncbi Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors
    X Gong
    Intramural Research Support Program, SAIC Frederick, NCI FCRDC, Frederick, Maryland 21702, USA
    J Biol Chem 272:11682-5. 1997
    Monocyte chemotactic protein (MCP)-2 is a member of the C-C chemokine subfamily, which shares more than 60% sequence homology with MCP-1 and MCP-3 and about 30% homology with macrophage inflammatory protein (MIP)-1alpha, regulated on ..
  91. pmc Induction of the gene encoding macrophage chemoattractant protein 1 by Orientia tsutsugamushi in human endothelial cells involves activation of transcription factor activator protein 1
    Nam Hyuk Cho
    Department of Microbiology and Immunology, Seoul National University College of Medicine, and Institute of Endemic Disease, Seoul National University Medical Research Center, Chongno Gu, Seoul 110 799, Republic of Korea
    Infect Immun 70:4841-50. 2002
    Human macrophage chemoattractant protein 1 (MCP-1) is a potent mediator of macrophage migration and therefore plays an essential role in early events of inflammation...
  92. ncbi The MCP-1-2518 (A to G) single nucleotide polymorphism in Czech patients with pulmonary sarcoidosis: association with Löfgren's syndrome
    Zdenka Navratilova
    Palacky University Olomouc, Czech Republic
    Sarcoidosis Vasc Diffuse Lung Dis 24:33-8. 2007
    The chemokine Monocyte Chemoattractant Protein (MCP)-1/CCL2, a chemoattractant for mononuclear cells, has already been implicated in the pathogenesis of sarcoidosis...
  93. pmc Absence of spermatozoal CD46 protein expression and associated rapid acrosome reaction rate in striped field mice (Apodemus agrarius)
    Leanne E Clift
    Division of Immunology, School of Infection and Host Defence, University of Liverpool, Liverpool, UK
    Reprod Biol Endocrinol 7:29. 2009
    In rodents, the cell surface complement regulatory protein CD46 is expressed solely on the spermatozoal acrosome membrane. Ablation of the CD46 gene is associated with a faster acrosome reaction...
  94. ncbi Effect of transdermal iontophoresis codelivery of hydrocortisone on metoclopramide pharmacokinetics and skin-induced reactions in human subjects
    M Cormier
    ALZA Corporation, 950 Page Mill Road, P O Box 10950, Palo Alto, California 94303 0802, USA
    J Pharm Sci 88:1030-5. 1999
    The effects of transdermal iontophoresis (IP) codelivery of hydrocortisone (HC) on metoclopramide hydrochloride (MCP) pharmacokinetics and on skin-induced reactions were evaluated in a randomized, crossover clinical study...
  95. ncbi Dual regulation of tumor necrosis factor-alpha-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-kappaB and activator protein-1: modulation by type III phosphodiesterase inhibition
    Yung Ming Chen
    Department of Medicine, National Taiwan University Hospital, 7, Chung Shan South Rd, Taipei, 10016, Taiwan
    J Pharmacol Exp Ther 309:978-86. 2004
    ..a critical initial step in atherogenesis, in which CC chemokine ligand 2 (CCL2)/monocyte chemoattractant protein-1 (MCP-1) is thought to play a key role...
  96. ncbi Monocyte chemoattractant protein 1-induced monocyte infiltration produces angiogenesis but not arteriogenesis in chronically infarcted myocardium
    Ernst R Schwarz
    Department of Cardiology, Rheinisch Westfaelisch Technische Hochschule University Hospital Aachen, Germany
    J Cardiovasc Pharmacol Ther 9:279-89. 2004
    Monocyte chemoattractant protein 1 (MCP-1) stimulates the invasion of monocytes into ischemic tissue with concomitant adhesion to endothelial cells...
  97. ncbi [Effects of induction of tubular epithelial-myofibroblast transition by monocyte chemoattractant protein-1 and mechanism thereof: an in vitro experiment]
    Hui lin Li
    Division of Nephrology, Peking Union Medical College Hospital, Peking Union Medical Chinese, Chinese Academy of Medical Scieces, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 88:400-5. 2008
    To examine the effects of monocyte chemoattractant protein-1 (MCP-1) on epithelial-myofibroblast transition (EMT) of renal proximal tubular epithelial cells and the possible mechanism involved.
  98. doi Porphyromonas gingivalis mediates the shedding and proteolysis of complement regulatory protein CD46 expressed by oral epithelial cells
    H Mahtout
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec City, QC, Canada
    Oral Microbiol Immunol 24:396-400. 2009
    ..In this study, we hypothesized that Porphyromonas gingivalis, the major etiological agent of chronic periodontitis, causes the shedding or proteolysis of the complement regulatory protein CD46 expressed by oral epithelial cells.
  99. ncbi [High mobility group box-1 stimulates proinflammatory cytokine production in endothelial cells via MAP kinases]
    Tian Yu Zhong
    Key Laboratory of Proteomics of Guangdong Province, Southern Medical University, Guangzhou 510515, China zhongtianyu gmail com
    Nan Fang Yi Ke Da Xue Xue Bao 29:1517-20. 2009
    ..protein and lipopolysaccharides (LPS) on the release of interleukin-8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) in human umbilic vein endothelial cells (HUVECs), and explore the role of mitogen-activated protein kinases (..
  100. ncbi Fusion of the thumb metacarpophalangeal joint to treat posttraumatic arthritis
    H J Hagan
    Indiana Center for Surgery and Rehabilitation of the Hand and Upper Extremity, Indianapolis
    J Hand Surg Am 13:750-3. 1988
    Thumb metacarpophalangeal (MCP) fusion to treat posttraumatic arthritis is retrospectively reviewed in 18 patients, 16 of whom were examined and functionally tested, with an average follow-up of 18 months. All patients were satisfied...
  101. pmc RANTES and MCP-3 inhibit the replication of T-cell-tropic human immunodeficiency virus type 1 strains (SF-2, MN, and HE)
    D Schols
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Virol 71:7300-4. 1997
    The effects of the C-C chemokines RANTES (regulation upon activation normal T-cell expressed and secreted) and MCP-3 (monocyte chemotactic protein 3) on human immunodeficiency virus (HIV) replication in normal human peripheral blood ..

Research Grants85

  1. Val S Goodfellow; Fiscal Year: 2014
    ..in the cerebrospinal fluid and postmortem brain tissues of HAND patients: TNF-??, the monocyte chemoattractant MCP-1, and mixed-lineage kinase 3 (MLK3), an important control point in MAPK kinase regulated inflammation pathways...
  2. Lipoprotein Receptors and Inflammation in the Vessel Wall
    Dudley K Strickland; Fiscal Year: 2011
    ..evidence that LRP increases the gene expression of several inflammatory cytokines and chemokines, including MCP-1...
  3. The Role of Microglia in Prolonged Anxiety-like Behavior following Social Stress
    Eric S Wohleb; Fiscal Year: 2013
    ..from RSD mice causes amplified production of inflammatory cytokines and chemokines, such as TNF-[unreadable], CCL2 (MCP-1), and IL-6...
  4. Ronald G Collman; Fiscal Year: 2015
    ..M/M releases cytokines, small molecules or viral proteins that injure neurons, as well as chemokines such as MCP-1 that recruit additional M/M...
  5. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..The purpose of this study is to investigate the mechanisms by which monocyte chemoattractant protein (MCP)-1 regulates liver regeneration. MCP-1 is a small, secreted protein in the family of C-C chemokines...
  6. Elizabeth J Kovacs; Fiscal Year: 2016
    ..and 2) increased pulmonary production of pro-inflammatory cytokines (IL-6 and TNFa) and chemokines (MIP-2 and MCP-1)...
  7. Molecular Mechanisms of Genistein in the Prevention of Inflammatory Cytokine (TNF
    Zhenquan Jia; Fiscal Year: 2010
    ..2) genistein significantly suppressed TNF-alpha-induced production of monocyte chemoattractant protein -1 (MCP-1) and interleukin-8 (IL-8), two chemokines that are the key factors in the firm adhesion of monocytes to activated ..
  8. 3D Culture of Adipose Tissue for Screening Obesity-related Drugs
    Kacey G Marra; Fiscal Year: 2012
    ..has been shown that involved cytokine behavior in obesity includes the increased expression of, but not limited to: MCP-1 (monocyte chemotactic protein-1, which can recruit macrophages to adipose tissue), TNF-1 (tumor necrosis factor-1,..
  9. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
    ..mice which inhaled CNTs have increased platelet-derived growth factor (PDGF) and monocyte chemotactic protein-1 (MCP-1), two important mediators of fibrosis, asthma, and pleural disease...
  10. T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced Obesity
    CHRISTIE MITCHELL BALLANTYNE; Fiscal Year: 2013
    ..T-cell expressed and secreted (RANTES) and its receptor, CCR5, along with monocyte chemoattractant protein-1 (MCP-1) and receptor CCR2, are upregulated in adipose tissue of obese insulin-resistant mice and in human visceral ..
  11. Role of SHP-1 in monocyte-mediated demyelination
    Paul T Massa; Fiscal Year: 2013
    ..Specific aim 2 will focus on the role for the chemokine MCP-1 and its receptor CCR2 in the spreading of TMEV to monocytes in peripheral tissues and eventual movement of these ..
  12. Harmeet Malhi; Fiscal Year: 2016
    ..enhancing macrophage activation and cytokine secretion via targeting the cytokines monocyte chemotactic protein-1 (MCP-1) and interleukin-1beta (IL-1[unreadable]), and ii) how the CHOP branch of the UPR increases the antiinflammatory ..
  13. Chemokines in pathogenesis of Experimental Arthritis
    SEEMA SINGH AHUJA; Fiscal Year: 2010
    Monocyte chemotactic protien-1 (MCP-1/CCL2) and its high affinity receptor CCR2 play a critical role in leukocyte migration and the generation of inflammatory response...
  14. Edgar A Jaimes; Fiscal Year: 2014
    ..of several pro- inflammatory and pro-fibrotic cytokines and will also determine the transcriptional regulation of MCP-1 and CTGF by ETS-1 in mesangial cells...
  15. Opioid Modulation of Inflammatory Monocyte Activity Involved in HIV Susceptibilit
    Thomas J Rogers; Fiscal Year: 2012
    ..on the expression of the critical chemokine receptor CCR2, as well as the very important pro-inflammtory chemokine MCP-1...
  16. Sex Hormones and the Innate Immune Response to Influenza Infection
    DIONNE ROBINSON; Fiscal Year: 2012
    ..One chemokine in particular, MCP-1, is significantly elevated in females as early as 3 days post-inoculation...
  17. MECHANISMS OF PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2010
    ..and is known to express several key cytokines with fibrogenic activities, including monocyte chemotactic protein-1 (MCP-1), transforming growth factors a (TGFa) and (}(TGFp)...
  18. Genistein for the Prevention and Treatment of Diabetic Vascular Inflammation
    Dongmin Liu; Fiscal Year: 2009
    ..analysis showed that genistein suppressed high glucose- induced production of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in human aortic ECs (HAECs), two chemokines that are the key factors in the firm ..
  19. Role of Cocaine in Neuro-AIDS by HIV 1B and C Clades
    Madhavan P Nair; Fiscal Year: 2012
    ..absence of cocaine on production and gene expression of pro-inflammatory cytokines, (TNF1 &IL-6), chemokines (MCP-1&RANTES), and neurotoxin (IDO) by primary monocytes and CNS cells (astrocytes, neurons, microglial cells), and ..
  20. Madhavan P Nair; Fiscal Year: 2014
    ..clade B and C virus on production and gene expression of pro-inflammatory cytokines (TNF1 &IL-6), chemokines (MCP-1 &RANTES), and neurotoxin (IDO) by primary monocytes and CNS cells (astrocytes, microglial cells) and examine (..
  21. Chaim Putterman; Fiscal Year: 2014
    ..Treatment of podocytes with TWEAK leads to increased expression of key pathogenic cytokines, including MCP-1, RANTES, VCAM-1, and IP-10...
  22. Pulmonary defense against aspergillus fumigatus
    Chad Steele; Fiscal Year: 2013
    ..fumigatus challenge, as are the chemokines CXCL12/SDF-1 and CCL2/MCP-1. These results suggest that Dectin-1 may control IL-17 levels in the lungs after A...
  23. Canine Influenza Virus Induction of TNF
    William L Castleman; Fiscal Year: 2013
    ..and equine influenza virus isolates to replicate in primary airway epithelial cells and induce chemokines (IL-8 and MCP-2)...
  24. Richard J Miller; Fiscal Year: 2015
    ..In particular, we shall investigate whether these cells are responsive to key chemokines such as SDF-1 and MCP-1 whose expression is upregulated as part of the innate immune response...
  25. Role of Darc-Chemokine Interaction in the Trafficking of Osteoclast Precursors
    Bouchra Edderkaoui; Fiscal Year: 2012
    ..dependent bone marrow cells derived from Darc-knockout (Darc-KO) mice exhibit reduced binding to chemokines such as MCP-1 and RANTES;2) femurs isolated from Darc-KO mice showed reduced TRAP positive bone resorbing surface compared to ..
  26. Gadiparthi N Rao; Fiscal Year: 2016
    ..wall remodeling in response to various cues, we have recently discovered that monocyte chemoattractant protein-1 (MCP-1), a potent chemokine that appears to play an important role in vascular diseases, possesses the capacity to ..
  27. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..emigration as well as lung levels of IL-17, IFN? as well as the downstream Th17 and Th1 target genes (KC, G-CSF, MCP-1 and MIG, IP-10 respectively)...
  28. Role of Epithelial Chemokines in Kidney Injury-Molecule-1 Induced Renal Fibrosis
    Benjamin D Humphreys; Fiscal Year: 2010
    ..kidney through epithelial cell production of the chemokines CXCL-1, CXCL-10 and macrophage chemoattract protein-1 (MCP-1)...
  29. Mechanisms of MCP-1 in lung contusion with and without gastric aspiration
    Krishnan Raghavendran; Fiscal Year: 2013
    ..Emphasis is on mechanistic understanding of the protective roles of MCP-1and MCP-5 in the pathogenesis of these injuries alone and in combination, including specific effects of this ..
  30. Dissecting the Role of HIV-1 Tat &Chemokine Axis in Subtype-Specificity of HAD
    Vinayaka R Prasad; Fiscal Year: 2012
    ..In Aim 3, we will examine the role of monocyte chemoattractant protein, MCP-1 and its receptor, CCR2 by first generating gene knockout mice lacking each of these genes respectively in the ..
  31. Marc B Hershenson; Fiscal Year: 2014
    ..neutrophilic and eosinophilic response that is mediated in part by macrophage production of eotaxin-1/CCL11 and MCP-1/CCL2...
  32. Guo Ping Shi; Fiscal Year: 2016
    ..Along with reduced body weight gain and increased glucose tolerance, serum levels of leptin, chemokine MCP-1, cytokine TNF-a, and obesity pertinent protease cathepsin S are also reduced in mast cell-deficient mice or those ..
  33. HO-1 and granuloma formation in TB pleurisy
    Veena B Antony; Fiscal Year: 2010
    ..the site of tuberculous infection by the interaction of C-C chemokines, (mainly monocyte chemoattractant protein-1, MCP- 1) and monocyte expression of the CCR2 receptor...
  34. Histone deacetylase 7 and its interacting proteins in endothelial cells
    Hung Ying Kao; Fiscal Year: 2013
    ..2) To investigate the mechanisms by which HDAC7 mediates TNF1-induced MCP-1 transcription...
  35. Alan Daugherty; Fiscal Year: 2015
    ..This infers a role for monocyte chemoattractant protein-1 (MCP-1) in TAAs, although CCR2 also interacts with other chemokines...
  36. In Vivo Brain Dialysis of Neuropeptides and Neuroimmune Signaling Proteins
    Julie A Stenken; Fiscal Year: 2012
    ..Our primary focus will be on a select group of cytokines and neuropeptides related to epilepsy (cytokines {CCL2 [MCP-1], CCL3 [MIP-1a], CCL4 [MIP-12], CCL5 [RANTES], KC/GRO, IL-1b, IL-6, IL-10, and TNF-a} and neuropeptides {..
  37. Mechanisms of Pulmonary Mast Cell Recruitment and Maturation
    MICHAEL FAGERSTEN GURISH; Fiscal Year: 2012
    ..Although MCs and MC progenitors (MCp) are sparse in mouse lung at baseline, the appearance of mature MCs in tracheobronchial epithelium (intraepithelial ..
  38. Identification of Molecular Interactions Between a Chemokine Receptor and Ligand
    CATHERINA L SALANGA; Fiscal Year: 2010
    ..aim to elucidate the molecular mechanism of activation of the chemokine receptor, CCR1, by the chemokine agonist, MCP-3...
  39. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
    ..CaOx and CaP crystals is associated with increased production of the chemokine, monocyte chemoattractant protein-1 (MCP-1)...
  40. MARIO TOMAS PHILIPP; Fiscal Year: 2014
    ..into the cerebrospinal fluid of rhesus macaques with Lyme meningitis is the chemokine C-C motif ligand 2 (CCL2, aka MCP-1)...
  41. Lisa R Young; Fiscal Year: 2016
    ..of the HPS2 defect significantly attenuated type II cell apoptosis, excess monocyte-chemotactic protein-1 (MCP-1) secretion, AM activation, and susceptibility to bleomycin-induced fibrosis...
  42. Effect of Nutritional Factors on Macrophage Accumulation in Adipose Tissue
    Alan Chait; Fiscal Year: 2012
    ..the expression in adipocytes of monocyte chemotactic factors, including monocyte chemoattractant protein-1 (MCP-1) and serum amyloid A3 (SAA3), the form of SAA produced by adipocytes...
  43. The role of MCPIP1 in regulating NF-kB signaling and macrophage activation
    Mingui Fu; Fiscal Year: 2012
    ..However, the molecular mechanisms limiting macrophage inflammation are not completely understood. MCP-induced protein 1 (MCPIP1) is a recently identified CCCH-zinc finger containing protein, which was significantly ..
  44. Israel F Charo; Fiscal Year: 2014
    ..other NIH funded worked we discovered and cloned CCR2, the chemokine receptor that regulates monocyte migration to MCP-1, and showed that CCR2-/- mice are protected in murine models of atherosclerosis...
  45. Bo Liu; Fiscal Year: 2014
    ..The pro-inflammatory function of PKCd is mediated through monocyte chemoattactant protein-1 (MCP-1)...
  46. Olga I Stenina; Fiscal Year: 2016
    ..Mechanistically reduced expression of multiple leukocyte adhesion molecules and monocyte chemotactic protein (MCP-1) by endothelial cells (EC) in TSP-4 KO mice leads to few macrophages (M[unreadable]) accumulating into developing ..
  47. Stuart B Goodman; Fiscal Year: 2016
    ..Monocyte Chemoattractant Protein-1 (MCP-1) is the most important chemokine regulating systemic and local trafficking of monocyte/macrophages in ..
  48. Victoria L Seewaldt; Fiscal Year: 2015
    ..Fat cells within the breast tissue of obese women secrete a monocyte chemo-attractant protein-1 (MCP-1) that promotes the recruitment of macrophages into breast adipose tissue...
  49. LAUREN ASHLEY COWART; Fiscal Year: 2016
    ..Specifically, we observed decreased levels of obesity-indcued proinflammatory cytokines including IL-6 and MCP-1, which may link obesity to its downstream pathology...
  50. MARINA CINTHIA PELUFFO; Fiscal Year: 2016
    ..The PI's preliminary results from domestic cats demonstrated that the chemokine MCP-1 and its receptor (CCR2) are expressed in the oocyte and cumulus cells of COCs from small antral follicles...
  51. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..Primary study outcomes are serum markers of inflammation including monocyte chemoattractant protein-1 (MCP-1), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-1) and soluble intercellular adhesion molecule-1 (sICAM-..
  52. Role of Bone Marrow-Derived Fibroblast Precursors in Cardiac Fibrosis
    Yanlin Wang; Fiscal Year: 2013
    ..g. MCP-1) which are also high in CKD...
  53. Neal L Weintraub; Fiscal Year: 2016
    ..Moreover, preliminary data suggest that transplanting PVAT from mice lacking the chemokine MCP-1 attenuates neointimal formation, consistent with pleiotropic effects of MCP-1 to promote vascular remodeling...
  54. Edward W Inscho; Fiscal Year: 2014
    ..Impaired autoregulation in hypertension coincides with increased renal cytokine production, such as TGF-2 and MCP-1, which may be involved in hypertension-induced renal microvascular dysfunction...
  55. Lara Longobardi; Fiscal Year: 2014
    ..The overall objective is to determine whether the regulation of the cytokine monocyte chemoattractant protein-5 (MCP-5) is a key down- stream mediator of TGF-alpha (a) type II receptor (TaRII) signaling in joint maintenance and post-..
  56. Robert E Taylor; Fiscal Year: 2016
    ..elucidate the mechanism responsible for the TLR4 effect, focusing on the chemokine monocyte chemotactic protein-1 (MCP-1) and the dopamine rate- limiting enzyme tyrosine hydroxylase (TH)--implicated by data obtained after the ..
  57. Supressor ANGII Determines Acute & Chronic Renal Injury
    Luis A Juncos; Fiscal Year: 2010
    ..e. monocyte chemoattractant protein-1;MCP-1) which promote renal injury...
  58. Role of TGF-Beta in the Recruitment of Bone Marrow Progenitors in Vascular Injury
    PASITHORN SUWANABOL; Fiscal Year: 2010
    ..array studies have demonstrated that in TGF-Beta-stimulated Smad3-expressing SMCs, Monocyte Chemotactic Protein-1 (MCP-1) is expressed over 80-fold...
  59. RETO H R ASMIS; Fiscal Year: 2015
    ..responsible for the deactivation of both phospho-ERK and phospho-p38MAPK, the two principal MAPK pathways mediating MCP-1-induced monocyte adhesions and migration...
  60. SETH BERNAT FURGESON; Fiscal Year: 2015
    ..Along with neointima size, we will measure production of chemokines (IL-6, MCP-1, SDF-11, and KC), recruitment of bone marrow-derived cells and macrophages, and cellular proliferation...
  61. Ceramide membrane microdomains regulate cytokine secretion
    Brij B Singh; Fiscal Year: 2013
    ..play a critical role in anti-microbial immunity by secreting cytokines, such as monocyte chemoattractant protein (MCP-1) against P. aeruginosa (PA) infection. However, the mechanism of cytokine secretion is largely unknown...
  62. Lung epithelium collaborates with alveolar macrophages in host defense
    Min Wu; Fiscal Year: 2012
    ..b>MCP-1 is a major chemokine secreted by alveolar epithelial cells type II (AECII)...
  63. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..cystatin C, ADMA, uric acid, 25(OH)vitamin D, parathyroid hormone);and (4) inflammation and hemostasis (hsCRP, MCP-1, IL-6, sTNFRII, sVCAM-1, sICAM-1, serum amyloid A, MMP-9, E-selectin, P-selectin, CD40 ligand, fibrinogen, von ..
  64. CT Evaluation of the Myocardial Effects of Risk Factors
    Lilach O Lerman; Fiscal Year: 2013
    ..rarefaction and remodeling, which are partly mediated by inflammation through monocyte chemoattractant protein-1 (MCP-1), and that consequent microvascular loss interferes with compensatory mechanisms meant to protect the heart from ..
  65. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..IL-2, IL4, IL-3, IL-5, IL-6, IL-7, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17, IP-10, KC, LIF, LIX, MCP-1, M-CSF, MIG, MIP-1[unreadable], MIP-1[unreadable], MIP-2, RANTES, TNF-[unreadable], and VEGF...
  66. Regulation of NFkappaB activity by the Estrogen Receptor
    Kendall W Nettles; Fiscal Year: 2012
    ..the molecular interactions required for ER-mediated suppression of NF-B, we will measure their recruitment to the MCP-1, IL-6, IL-8, MIP-1 and TNF-a genes by chromatin immunoprecipitation, and assay the effects of RNA interference ..
  67. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..6, 24, and 44 weeks) and use QD-antibody conjugates injected in vivo to detect the inflammatory markers VCAM-1, MCP-1, MSR, and dimerized fibrin (D-dimer) on plaque surfaces, which serve as relatively early and late indicators of ..
  68. Adonis K Hijaz; Fiscal Year: 2014
    ..injury) and delayed recovery from VD induced SUI;c) following VD, expression of monocyte chemotactic protein-3 (MCP-3)- a mesenchymal stem cell (MSC) homing cytokine- is dramatically increased in the urethra;and d) selective homing ..
  69. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..increases the level of antioxidant enzyme Superoxide Dismutase, and reduces pro-inflammatory factors TNF-alpha, MCP-1, and RANTES. Recently, we further identified the active component of AX-3...
  70. Mechanisms of Astrocyte Development
    Teri L Belecky Adams; Fiscal Year: 2010
    ..in the regulation of Pax2 in primary retinal astrocytes by moderating the activity of the suppressor protein TLX. The studies proposed in this application involve a multi-disciplinary approach, including 1) in vitro and in vivo ..
  71. Effects of Metabolic Disorders on Bone Marrow-Derived Cell Function
    Gina C Schatteman; Fiscal Year: 2012
    ..four molecules, tumor necrosis factor alpha (TNF1), interleukin 12 (IL-12), monocyte chemoattractant factor 1 (MCP-1), and vascular endothelial growth factor A (VEGF-A) that share a common regulatory pathway that appears to ..
  72. K Craig Kent; Fiscal Year: 2016
    ..Moreover, we will test the hypothesis that monocyte chemoattractant protein-1 (MCP-1) is the chemoattractant that mediates TGF-2 and Smad3's effect...
  73. Lilach O Lerman; Fiscal Year: 2015
    ..renal MV remodeling that is partly mediated by inflammation, and in which monocyte chemoattractant protein-1 (MCP-1) plays a pivotal role...
  74. CLINICAL/EXPERIMENTAL RADIATION RESEARCH
    Paul Okunieff; Fiscal Year: 2002
    ..to these early cytokines by triggering in turn the CC chemokine family of genes--monocyte chemoattractant proteins MCP-1, MCP-2, MCP-3, the macrophage inflammatory proteins MIP-1alpha, MIP-1beta, and RANTES--all of which have ..
  75. CHEMOKINES AND IMMUNE DISEASES
    Lili Feng; Fiscal Year: 2000
    ..Preliminary studies with recombinant MCP-1 RA generated in E. coli...
  76. THE CHEMOKINE RECEPTOR CXCR-2 IN ATHEROSCLEROSIS
    William Boisvert; Fiscal Year: 2002
    ..in part from observations by others, including the finding that in apoE knockout mice which are deficient in the MCP-1 receptor CCR2, atherosclerosis is diminished, but lesion size and complexity still progress from 5-13 weeks...
  77. ROLE OF CD46 IN MEASLES ENTRY AND IMMUNOSUPPRESSION
    Marianne Manchester; Fiscal Year: 2004
    ..For MV, the cell-surface receptor has been identified as the complement receptor CD46. The normal function of CD46 is to bind complement components on the cell surface and prevent their deposition on ..
  78. VIRUS-RECEPTOR INTERACTIONS IN MEASLES PATHOGENESIS
    Marianne Manchester; Fiscal Year: 2000
    ..For MV, the cell-surface receptor has been identified as the complement receptor CD46. The normal function of CD46 is to bind complement components on the cell surface and prevent their deposition on ..
  79. PLATELET REGULATION OF MONOKINE SYNTHESIS
    ANDREW WEYRICH; Fiscal Year: 2000
    ..Among the IE genes expressed, interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) were synthesized and secreted by monocytes exposed to activated platelets...
  80. MEASLES VIRUS AND ITS CELLULAR RECEPTOR CD46
    Thilo Stehle; Fiscal Year: 2003
    ..We will determine the three- dimensional structures of measles virus hemagglutinin and of human CD46, a measles virus receptor. The physiological role for CD46 is as a cofactor that accelerates the deactivation of the third and ..
  81. OXIDANT INDUCED BETA CHEMOKINES IN GRANULOMA FORMATION
    Jeffrey Warren; Fiscal Year: 2000
    ..Monocyte chemoattractant protein-1 (MCP-1) activity is required for full development of granulomas. There is an early (1-4 hrs...
  82. MONOCYTE CHEMOATTRACTANT PROTEIN 1 IN THE CORPUS LUTEUM
    PAUL KEYES; Fiscal Year: 1999
    ..in the rat corpus luteum is mediated by the chemokine, monocyte chemoattractant/activating protein l (MCP-l), and that the expression of this protein is essential for the physiological destruction of the corpus luteum...
  83. CD46: Protecting the Host from Complement Attack
    JOHN PATTERSON ATKINSON; Fiscal Year: 2010
    b>Membrane cofactor protein (MCP, CD46) is a complement regulatory protein that binds C3b andC4b and serves as a cofactor for their limited protedytic degradation...
  84. CHEMOKINE THERAPEUTIC TARGETS FOR KIDNEY DISEASE
    VICKI KELLEY; Fiscal Year: 2004
    ..Monocyte chemoattractant protein-1(MCP-1) belongs to a family of "chemokines" which attract leukocytes to tissues targeted for inflammation...

Patents1

  1. CD46 VARIANTS
    Patent Number: WO9118097-A1; Date:1991-11-28