CD45

Summary

Gene Symbol: CD45
Description: protein tyrosine phosphatase, receptor type C
Alias: B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, receptor-type tyrosine-protein phosphatase C, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide
Species: human

Top Publications

  1. pmc Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR
    M Streuli
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    EMBO J 9:2399-407. 1990
  2. ncbi Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase
    N K Tonks
    Department of Biochemistry, University of Washington, Seattle 98195
    Biochemistry 27:8695-701. 1988
  3. pmc Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain
    T Furukawa
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 91:10928-32. 1994
  4. ncbi Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease
    C Kung
    Howard Hughes Medical Institute, St Louis, Missouri 63110, USA
    Nat Med 6:343-5. 2000
  5. ncbi A point mutation in PTPRC is associated with the development of multiple sclerosis
    M Jacobsen
    Department of Neurology, Philipps University, Marburg, Germany
    Nat Genet 26:495-9. 2000
  6. ncbi A deletion in the gene encoding the CD45 antigen in a patient with SCID
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, United Kingdom
    J Immunol 166:1308-13. 2001
  7. ncbi Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis
    A Elhabazi
    Institut National de la Sante et de la Recherche Medicale, Unité 448, Faculté de Médecine de Créteil, Creteil, France
    J Immunol 166:4341-7. 2001
  8. ncbi Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45
    T A Baldwin
    Department of Medical Microbiology and Immunology, 6 70 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada, T6G 2S2
    J Immunol 167:3829-35. 2001
  9. ncbi Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population
    Clara Ballerini
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Pieraccini 6, 50134, Florence, Italy
    Neurosci Lett 328:325-7. 2002
  10. ncbi Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases
    Christophe Blanchetot
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands
    J Biol Chem 277:47263-9. 2002

Research Grants

  1. P-glycoprotein Function in Allograft Rejection
    Markus Frank; Fiscal Year: 2004
  2. Impact of genetic variation on response to GO therapy in COG-AML clinical trials
    ROLAND BRUNO WALTER; Fiscal Year: 2013
  3. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
  4. Davide Trotti; Fiscal Year: 2015
  5. Kenneth A Krohn; Fiscal Year: 2015
  6. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
  7. Hong Gang Wang; Fiscal Year: 2016
  8. Hans Schreiber; Fiscal Year: 2016
  9. Vijay Sharma; Fiscal Year: 2015
  10. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013

Detail Information

Publications2699 found, 100 shown here

  1. pmc Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR
    M Streuli
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    EMBO J 9:2399-407. 1990
    ..analyzed the effects of deletion and point mutations within the cytoplasmic region of the receptor-linked PTPases, LCA and LAR...
  2. ncbi Demonstration that the leukocyte common antigen CD45 is a protein tyrosine phosphatase
    N K Tonks
    Department of Biochemistry, University of Washington, Seattle 98195
    Biochemistry 27:8695-701. 1988
    It has been proposed on the basis of amino acid sequence homology that the leukocyte common antigen CD45 represents a family of catalytically active, receptor-linked protein tyrosine phosphatases [Charbonneau, H., Tonks, N. K., Walsh, K...
  3. pmc Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain
    T Furukawa
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 91:10928-32. 1994
    The CD45 transmembrane protein-tyrosine phosphatase (PTPase, EC 3.1.3.48) plays an essential role in T-cell activation by activating the Lck and/or Fyn protein-tyrosine kinases...
  4. ncbi Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease
    C Kung
    Howard Hughes Medical Institute, St Louis, Missouri 63110, USA
    Nat Med 6:343-5. 2000
    The hematopoietic-specific transmembrane protein tyrosine phosphatase CD45 functions to regulate Src kinases required for T- and B-cell antigen receptor signal transduction...
  5. ncbi A point mutation in PTPRC is associated with the development of multiple sclerosis
    M Jacobsen
    Department of Neurology, Philipps University, Marburg, Germany
    Nat Genet 26:495-9. 2000
    ..role of a point mutation in the gene (PTPRC) encoding protein-tyrosine phosphatase, receptor-type C (also known as CD45) in the heterozygous state in the development of MS...
  6. ncbi A deletion in the gene encoding the CD45 antigen in a patient with SCID
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, United Kingdom
    J Immunol 166:1308-13. 2001
    ..investigated the first SCID patient to be described with minimal cell surface expression of the leukocyte common (CD45) Ag...
  7. ncbi Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis
    A Elhabazi
    Institut National de la Sante et de la Recherche Medicale, Unité 448, Faculté de Médecine de Créteil, Creteil, France
    J Immunol 166:4341-7. 2001
    ..Mainly, these findings shed light on a possible function for the semaphorin region of CD100 as a long range guidance cue in the immune system...
  8. ncbi Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45
    T A Baldwin
    Department of Medical Microbiology and Immunology, 6 70 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada, T6G 2S2
    J Immunol 167:3829-35. 2001
    Glucosidase II (GII) stably interacts with the external domain of CD45 in a carbohydrate-dependent manner. We have found that the association occurs in immature cells, but is significantly reduced in mature T cells...
  9. ncbi Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population
    Clara Ballerini
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Pieraccini 6, 50134, Florence, Italy
    Neurosci Lett 328:325-7. 2002
    ..mutation in position 77 of exon 4 of the protein tyrosine phosphatase receptor-type C (PTPRC) gene, coding for the CD45 molecule, for the development of multiple sclerosis (MS) in an Italian continental population...
  10. ncbi Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases
    Christophe Blanchetot
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands
    J Biol Chem 277:47263-9. 2002
    ..Seven RPTPs from four different subfamilies were used: RPTPalpha, RPTPepsilon, LAR, RPTPvarsigma, RPTPdelta, CD45, and RPTP(mu). We found that RPTP-D2s bound to RPTPs with different affinities...
  11. ncbi The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death
    Maho Amano
    Department of Pathology and the Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Biol Chem 278:7469-75. 2003
    ..Expression of the ST6Gal I specifically resulted in increased sialylation of N-glycans on CD45, a receptor tyrosine phosphatase that is a T cell receptor for galectin-1...
  12. ncbi 77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link
    A Vogel
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, D 30625 Hannover, Germany
    Genes Immun 4:79-81. 2003
    ..Here we analyzed the genetic association of the tyrosine phosphatase CD45 and autoimmune hepatitis...
  13. ncbi Enhanced frequency of a PTPRC (CD45) exon A mutation (77C-->G) in systemic sclerosis
    R Schwinzer
    Transplantionslabor, Klinik für Viszeral und Transplantationschirugie, Zentrum Chirugie
    Genes Immun 4:168-9. 2003
    A point mutation in exon A (C to G transversion at position 77) of human PTPRC (CD45) has recently been associated with the development of multiple sclerosis (MS) for at least a subgroup of patients...
  14. ncbi CD45 (PTPRC) as a candidate gene in multiple sclerosis
    Tamara Vyshkina
    Department of Neurology, SLRHC, Columbia University, New York, NY 10019, USA
    Mult Scler 10:614-7. 2004
    The 77C-->G polymorphism in exon 4 of CD45 or protein tyrosine phosphatase receptor-type C (PTPRC) has been investigated in families with multiple sclerosis (MS) and in several cohorts of sporadic patients and controls, however, with ..
  15. ncbi alpha2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: insights into differential effects on CD45RO and CD45RA T cells
    Eliran Ish-Shalom
    Goldyne Savad Institute of Gene Therayp, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Glycobiology 16:173-83. 2006
    ..The recent demonstration of PP14 as lectin has provided insight into how it may mediate its CD45 glycoprotein-dependent T-cell inhibition...
  16. ncbi The 77C->G mutation in the human CD45 (PTPRC) gene leads to increased intensity of TCR signaling in T cell lines from healthy individuals and patients with multiple sclerosis
    Hue Tran Do
    Transplantationslabor, Klinik für Viszeral und Transplantationschirurgie, Hannover, Germany
    J Immunol 176:931-8. 2006
    The 77C-->G mutation in exon A of the human CD45 gene occurs with low frequency in healthy individuals...
  17. ncbi Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, Amsterdam, The Netherlands
    Nat Immunol 7:1200-8. 2006
    ..Glycosylation-dependent interactions of MGL with CD45 on effector T cells negatively regulated T cell receptor-mediated signaling and T cell-dependent cytokine responses,..
  18. ncbi Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation
    J T Pingel
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    Cell 58:1055-65. 1989
    ..An L-CA+ revertant was obtained and the ability to proliferate in response to antigen and cross-linked CD3 was restored. These data indicate that L-CA is required for T cells to enter into cell cycle in response to antigen...
  19. pmc Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens
    M Streuli
    Division of Tumor Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    J Exp Med 166:1548-66. 1987
    Leukocyte common antigens (LCAs, also known as T200 and CD 45) are integral membrane proteins expressed exclusively on hematopoietic cells...
  20. ncbi Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase
    T Mustelin
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Eur J Immunol 25:942-6. 1995
    ..In addition, the CD45 phosphotyrosine phosphatase (PTPase) is required for the induction of tyrosine phosphorylation by the TcR/CD3, ..
  21. ncbi PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients
    L F Barcellos
    Department of Neurology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Genet 29:23-4. 2001
    ..nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS)...
  22. ncbi Does 77C-->G in PTPRC modify autoimmune disorders linked to the major histocompatibility locus?
    I Vorechovsky
    University College London Royal Free Campus, UK
    Nat Genet 29:22-3. 2001
    A 77G allele of the gene encoding CD45, also known as the protein tyrosine phosphatase receptor-type C gene (PTPRC), has been associated with multiple sclerosis (MS)...
  23. ncbi CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease
    J P Wood
    Medical Department 1, Division of Endocrinology, Centre of Internal Medicine, Johann Wolfgang Goethe University Hospital, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Eur J Immunogenet 29:73-4. 2002
    A point mutation in the leukocyte common antigen (CD45, C-->G77, exon 4) was investigated in patients with type 1 diabetes (IDDM), patients with Graves' disease and controls...
  24. pmc PTPRC (CD45) is not associated with multiple sclerosis in a large cohort of German patients
    Bianca Miterski
    Department of Molecular Human Genetics, Ruhr University, 44780 Bochum, Germany
    BMC Med Genet 3:3. 2002
    ..the 77C-->G transition in exon 4 of the protein-tyrosine phosphatase receptor-type C (PTPRC also known as CD45) in a large cohort of German MS patients and controls...
  25. ncbi Negative regulation of T cell activation by placental protein 14 is mediated by the tyrosine phosphatase receptor CD45
    Jacob Rachmilewitz
    Goldyne Savad Institute of Gene Therapy, Hadassah University Hospital, Jerusalem 91120, Israel
    J Biol Chem 278:14059-65. 2003
    b>CD45 is the major protein tyrosine phosphatase receptor on T cell surfaces that functions as both a positive and a negative regulator of T cell receptor (TCR) signaling...
  26. ncbi CD45 isoform expression in autoimmune myasthenia gravis
    B Tackenberg
    Department of Neurology, Philipps University, Rudolf Bultmann Street 8, D 35033 Marburg, Germany
    Autoimmunity 36:117-21. 2003
    ..In this study, we investigated the role of the CD45 molecule in MG, having recently reported an association in multiple sclerosis...
  27. ncbi CD45 and multiple sclerosis: the exon 4 C77G polymorphism (additional studies and meta-analysis) and new markers
    Macarena Gomez-Lira
    Dipartimento Materno Infantile e di Biologia Genetica, Sezione di Biologia e Genetica, Universita di Verona, Verona, Italy
    J Neuroimmunol 140:216-21. 2003
    We re-evaluated the association with multiple sclerosis (MS) of the C77G splicing regulatory variation in the CD45 gene and screened for new mutations the three alternatively spliced exons (#4, 5 and 6)...
  28. ncbi A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population
    H Thude
    Institute for Transfusion Medicine, University of Jena, Jena, Germany
    Eur J Immunogenet 31:245-7. 2004
    To investigate whether a C to G transversion at position 77 in exon A of the CD45 gene is associated with the development of diabetes mellitus type 1 (T1D), we studied 165 patients and 220 control individuals...
  29. ncbi C77G mutation in protein tyrosine phosphatase CD45 gene and autoimmune hepatitis
    Fatemehsadat Esteghamat
    Research Center for Gastroenterology and Liver Disease, 7th Floor, Taleghani Hospital, Tabnak St, Evin, P O Box 19835 178, Tehran, Iran Khatam University, Tehran, Iran
    Hepatol Res 32:154-7. 2005
    ..In this study, we investigated the involvement of C77G mutation in CD45 gene in patients with autoimmune hepatitis among Iranian population by genotyping this mutation in 70 patients and ..
  30. ncbi No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene
    Holger Kirsten
    Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Leipzig, Germany
    J Rheumatol 35:1817-9. 2008
    The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians. We analyzed this association in an independent, larger German cohort.
  31. doi Extracellular ligation-dependent CD45RB enzymatic activity negatively regulates lipid raft signal transduction
    Kaushal Parikh
    Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 113:594-603. 2009
    b>CD45 is the most prominent membrane protein on lymphocytes...
  32. doi An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population
    Attila L Szvetko
    Genomics Research Centre, Griffith Institute for Health and Medical Research, School of Medical Science, Griffith University, Gold Coast Campus, PMB50 GCMC Qld 9726, Queensland, Australia
    Brain Res 1255:148-52. 2009
    ..The Protein tyrosine phosphatase receptor type C gene (PTPRC) encodes the T-cell receptor CD45. Variations within PTPRC have been previously associated with diseases of autoimmune origin such as type 1 diabetes ..
  33. pmc Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy
    Jing Cui
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 62:1849-61. 2010
    ..The aim of the present study was to test established RA genetic risk factors to determine whether the same alleles also influence the response to anti-TNF therapy...
  34. ncbi Subdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylation
    Jackie Felberg
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 279:3455-62. 2004
    b>CD45 is a transmembrane, two-domain protein-tyrosine phosphatase expressed exclusively in nucleated hematopoietic cells...
  35. ncbi CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion
    C Herold
    INSERM U448, Faculty of Medicine, Creteil, France
    J Immunol 157:5262-8. 1996
    ..the molecular relationship between CD100 and another surface structure involved in human T cell proliferation, the CD45 phosphatase...
  36. ncbi Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45
    L B Justement
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO
    Science 252:1839-42. 1991
    b>CD45 is a member of a family of membrane proteins that possess phosphotyrosine phosphatase activity, and is the source of much of the tyrosine phosphatase activity in lymphocytes...
  37. ncbi Phosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis
    Y Wang
    Department of Microbiology, Michigan State University, East Lansing, Michigan 48824 1101, USA
    J Biol Chem 274:7454-61. 1999
    b>CD45 is a receptor-type protein-tyrosine phosphatase (PTP) that is required for antigen-specific stimulation and proliferation in lymphocytes...
  38. ncbi Aggressive small cell tumor of the skull base
    M Arnesen
    Department of Pathology, Abbott Northwestern Hospital, Minneapolis, Minnesota 55407
    Ultrastruct Pathol 18:191-7. 1994
    ..The distinction of pituitary adenomas and particularly of prolactin cell tumors from other adenoma types and from other small cell lesions markedly affects therapy and patient prognosis...
  39. ncbi Lymphohistiocytoid mesothelioma: a rare lymphomatoid variant of predominantly sarcomatoid mesothelioma
    D W Henderson
    Department of Pathology, Flinders Medical Centre, Bedford Park, South Australia
    Ultrastruct Pathol 12:367-84. 1988
    ..Our observations suggest that immunocytochemical or ultrastructural evaluation is mandatory for accurate diagnosis of all pleura-based lymphomatoid lesions with a mixed large and small cell pattern...
  40. ncbi Pleural mesothelioma presenting as an axillary lymph node metastasis with anemone cell appearance
    J Lloreta
    Servei de Patologia, Hospital Universitari del Mar, Barcelona, Spain
    Ultrastruct Pathol 18:293-8. 1994
    ..A pleural needle biopsy confirmed the pleural origin of the proliferation. The patient refused treatment and died 3 years after diagnosis...
  41. ncbi A filiform large cell lymphoma in the spleen: a case report with immunohistochemical and electron microscopic study
    T Ishihara
    First Department of Pathology, Yamaguchi University School of Medicine, Japan
    Ultrastruct Pathol 14:193-9. 1990
    ..They appeared to be parallel but were frequently undulated, curved, or branching, forming in places small tufts. The pattern was more clearly noted on thick sections examined at an accelerating voltage of 200 kV...
  42. ncbi Alveolar rhabdomyosarcoma arising in the nasal cavity of a 3-year-old child
    R J Pardo
    Department of Dermatology, University of Miami School of Medicine, Florida
    Pediatr Dermatol 5:254-6. 1988
    ..These observations are consistent with the diagnosis of alveolar rhabdomyosarcoma...
  43. ncbi Ki-1 lymphoma: a case report
    R Yowell
    LDS Hospital Electron Microscopy Laboratory, University of Utah, Salt Lake City 84143
    Ultrastruct Pathol 16:11-6. 1992
    ..Ultrastructural examination showed pleomorphic tumor cells with irregular nuclei, large nucleoli, and abundant complex cytoplasm with varied organelles...
  44. ncbi Mechanisms of multidrug resistance in cancer treatment
    A L Harris
    Molecular Oncology Laboratory, University of Oxford, John Radcliffe Hospital, Headington, UK
    Acta Oncol 31:205-13. 1992
    ..g. A45. 5) Drug activation. Mitomycin C as well as cyclophosphamide and VP16 require activation for their effects. Low levels of cytochrome p450 reductase are associated with MMC resistance...
  45. pmc Platelet membrane glycoproteins: role in primary hemostasis and component antigens
    D S Beardsley
    Division of Pediatric Hematology, Yale University School of Medicine, New Haven, CT 06510
    Yale J Biol Med 63:469-75. 1990
    ..Current research efforts include characterization of antigenic epitopes, elucidation of mechanisms by which platelet immunization occurs, and determination of the clinical implications of the presence of various platelet antibodies...
  46. ncbi [Treatment of multidrug resistance in oncology and hematology]
    M Petrini
    U.O. Ematologia, , Italy
    Tumori 83:S17-20. 1997
    ..In kidney and lung cancer samples examined, a low percentage of positive samples was detected without any relationship to the evaluated clinical parameters...
  47. ncbi [Erythropoietin: biochemical characteristics, biologic effects, indications and results of use in hematology]
    A M Marmont
    II Divisione di Ematologia, Ospedale San Martino, Genova, Italy
    Tumori 83:S3-15. 1997
    ..Although extremely expensive, this treatment may be life-saving when an otherwise successful allogeneic transplant is at the risk of failure because of this relatively uncommon but severe immunohematologic complication...
  48. ncbi The effects of xenobiotics on the structure and function of thyroid follicular and C-cells
    C C Capen
    Ohio State University, Department of Veterinary Pathobiology, Columbus 43210
    Toxicol Pathol 17:266-93. 1989
    ..Focal or diffuse hyperplasia often precedes the development of C-cell neoplasms. Radiation and the feeding of diets high in vitamin D resulting in hypercalcemia have been reported to increase the incidence of C-cell tumors in rats...
  49. ncbi Characterization of distinct layers of the Mycobacterium avium envelope in respect of their composition by fatty acids, proteins, oligosaccharides and antigens
    H L David
    Unite de la Tuberculose et des Mycobacteries, Institut Pasteur, Paris, France
    Zentralbl Bakteriol Mikrobiol Hyg A 268:193-208. 1988
    ..A 58 Kd protein was present in both the CM and the CYT. The CYT and CM antigens were found absent in surface antigens extracted using sodium dodecyl sulphate (SDS)...
  50. ncbi Corticotropin-releasing hormone-binding protein and its possible role in neuroendocrinological research
    X J Zhao
    Department of Internal Medicine I, University of Leipzig, Germany
    Horm Metab Res 29:373-8. 1997
    ....
  51. ncbi A point mutation within CD45 exon A is the cause of variant CD45RA splicing in humans
    C F Zilch
    Imperial Cancer Research Fund, Tumour Immunology Unit, University College London Medical School, GB
    Eur J Immunol 28:22-9. 1998
    The leukocyte common antigen (CD45) is alternatively spliced, generating various isoforms expressed on hemopoietic cells...
  52. ncbi Manipulation of CD45 antigen in transplantation tolerance
    Saiho Ko
    First Department of Surgery, Nara Medical University, Kashihara, Japan
    Curr Mol Med 2:249-55. 2002
    b>CD45 is known to have tyrosine phosphatase activity for signal transduction of T cells. Immunomodulation of CD45 has been tried to prevent T cell-mediated graft rejection in organ transplantation...
  53. ncbi CD45 (leukocyte common antigen) immunoreactivity in metastatic undifferentiated and neuroendocrine carcinoma: a potential diagnostic pitfall
    M A Nandedkar
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 11:1204-10. 1998
    Leukocyte common antigen (CD45/LCA) and keratin expression are generally mutually exclusive in diagnostic surgical pathology...
  54. ncbi Structural study of the sugar chains of human leukocyte common antigen CD45
    T Sato
    Department of Biochemistry, University of Tokyo, Japan
    Biochemistry 32:12694-704. 1993
    The leukocyte cell surface glycoprotein CD45 is a protein tyrosine phosphatase and is involved in signal transduction mediated by the T cell antigen receptor...
  55. ncbi Immunophenotype and clinical characteristics of CD45-negative and CD45-positive childhood acute lymphoblastic leukemia
    R Ratei
    Department of Hematology, Oncology and Tumor Immunology, Robert Rossle Klinik, Charité Campus Berlin Buch, Humboldt University of Berlin, Germany
    Ann Hematol 77:107-14. 1998
    To evaluate the expression pattern of the leukocyte common antigen CD45 in acute leukemias and to investigate whether the lack of CD45 expression in childhood acute lymphoblastic leukemia (ALL) is associated with other immunophenotypic ..
  56. ncbi Proliferation of immature myeloma cells by interleukin-6 is associated with CD45 expression in human multiple myeloma
    H Ishikawa
    Department of Immunohematology, Yamaguchi University School of Medicine, Ube, Japan
    Leuk Lymphoma 39:51-5. 2000
    ..The expression of the CD45 molecule on myeloma cells is quite variable, and the physiological consequence of CD45 on myeloma cells is still ..
  57. ncbi Hematopoietic and immunomodulatory effects of lytic CD45 monoclonal antibodies in patients with hematologic malignancy
    Robert A Krance
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Blood Marrow Transplant 9:273-81. 2003
    The CD45 antigen is present on all cells of the hematopoietic lineage. In some rodent models, lytic CD45 monoclonal antibodies (MAbs) induce complete marrow aplasia...
  58. pmc CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice
    Yuyan Zhu
    Department of Psychiatry and Behavioral Medicine, University of South Florida, Tampa, FL 33613, USA
    J Neurosci 31:1355-65. 2011
    Converging lines of evidence indicate dysregulation of the key immunoregulatory molecule CD45 (also known as leukocyte common antigen) in Alzheimer's disease (AD)...
  59. ncbi Expression and secretion of beta-galactosidase in Saccharomyces cerevisiae using the signal sequences of GgpI, the major yeast glycosylphosphatidylinositol-containing protein
    R Pignatelli
    Dipartimento di Fisiologia e Biochimica Generali, , Italy
    Biotechnol Appl Biochem 27:81-8. 1998
    ....
  60. ncbi Differential modulation of integrin receptors and extracellular matrix laminin by transforming growth factor-beta 1 in rat alveolar epithelial cells
    N M Kumar
    Department of Internal Medicine, SUNY at Buffalo School of Medicine, Buffalo General Hospital 14203, USA
    Exp Cell Res 221:385-94. 1995
    ..The same treatment resulted in increased laminin protein expression. These data suggest that TGF beta 1 may regulate alveolar epithelial cell differentiation in part through its modulation of integrins and laminin chains...
  61. pmc A sorting signal for the basolateral delivery of the vesicular stomatitis virus (VSV) G protein lies in its luminal domain: analysis of the targeting of VSV G-influenza hemagglutinin chimeras
    T Compton
    Department of Cell Biology, New York University Medical Center, New York 10016
    Proc Natl Acad Sci U S A 86:4112-6. 1989
    ..These results indicate that information specifying the basolateral transport of the G glycoprotein is located within the first 426 N-terminal amino acids of its ectoplasmic portion...
  62. ncbi [Effect of macrolide antibiotics on airway goblet hypersecretion in guinea pigs]
    J Tamaoki
    First Department of Medicine, Tokyo Women's Medical College, Japan
    Kansenshogaku Zasshi 70:591-6. 1996
    ..These results suggest that macrolides protect against goblet cell hypersecretion probably through an inhibition of recruitment of neutrophils into the airway mucosa...
  63. ncbi Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent
    W W Li
    Laboratories of Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 7:2908-11. 2001
    ..ET-743 is an extremely potent cytotoxic agent against human STS cell lines and is being evaluated as an antitumor agent in this disease...
  64. ncbi Biochemical characteristics and recent biological knowledge on prostate-specific antigen
    E Seregni
    Nuclear Medicine Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Tumori 82:72-7. 1996
    ..These new findings will have implications for the clinical application of PSA as a tumor marker for prostate cancer...
  65. ncbi Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells
    M Reyes
    Stem Cell Institute, Department of Medicine, and Cancer Center, University of Minnesota Medical School, Minneapolis 55455, USA
    Blood 98:2615-25. 2001
    ..MPCs were selected by depleting bone marrow mononuclear cells from more than 30 healthy human donors of CD45(+)/glycophorin-A (GlyA)(+) cells...
  66. ncbi Pathology of aging B6;129 mice
    D C Haines
    Veterinary Pathology Section, Pathology Histotechnology Laboratory, SAIC Frederickm, National Institutes of Health, Bethesda, Maryland 20892, USA
    Toxicol Pathol 29:653-61. 2001
    ..The lymphoma most often appeared to arise in the mesenteric node. Immunohistochemistry revealed CD45R expression as well as infiltration by many CD3+ T cells...
  67. ncbi [Effects of angiotensin II and pressure on cellular fibronectin in the vascular wall in organotypic culture]
    N Bardy
    INSERM U141, , Paris
    Arch Mal Coeur Vaiss 87:991-5. 1994
    ..Our results indicate that both angiotensin II and transmural pressure can induce fibronectin expression in the arterial wall, and both act synergically...
  68. ncbi Characterization by capillary electrophoresis of the surface glycoproteins of ovine lentiviruses before and after treatment with glycosidic enzymes
    M J Schmerr
    National Animal Disease Center, USDA, Ames, IA 50010
    J Chromatogr A 652:199-205. 1993
    ..From these results we have concluded that the carbohydrate moieties play an important role in contributing to the surface charge of SU. This charge affects the nature of its surface epitopes and has an impact on its biological function...
  69. pmc EDRF release from canine coronary artery by lectins
    J F Kleha
    Cardiovascular Research, Berlex Biosciences, Richmond, California 94804
    Br J Pharmacol 110:1473-8. 1993
    1. The effect of wheat germ agglutinin (WGA), concanavalin A (Con A) and lentil lectin agglutinin (LCA) were investigated on pre-contracted canine coronary artery rings in vitro. 2...
  70. ncbi Tissue-specific regulation of growth factors and clusterin by angiotensin II
    K H Yoo
    Department of Pediatrics, Korea University, Seoul
    Am J Hypertens 11:715-22. 1998
    ..Suppression of clusterin expression in the liver of hypertensive rats may represent a specific response to high levels of circulating ANG II or a response to hypertensive injury...
  71. ncbi Pathology of perbutylated-N-butyl-1-deoxynojiromycin (an alpha-glucosidase-1 inhibitor) in Sprague-Dawley rats
    K N Khan
    Department of Product Safety Assessment, Searle Research and Development, Skokie, Illinois 60077, USA
    Toxicol Pathol 24:531-8. 1996
    ....
  72. ncbi [Clinical, morphologic and immunophenotypic data based on 10 cases of canine muco-cutaneous epidermotropic T-lymphoma (analogous to Mycosis Funcgoïde). Important of an animal model of spontaneous pathology]
    J P Magnol
    ,
    Bull Acad Natl Med 180:449-62. 1996
    ..For our 10 cases, all the cells of lymphocytic morphology were, without exception, CD3+ and CD45+, irrespective of their situation within the epithelium or the chorion...
  73. ncbi [Von Willebrand factor in coronary disease]
    P Soskin
    Service de cardiologie, ,
    Arch Mal Coeur Vaiss 87:85-93. 1994
    ..Increased VWF concentrations are not proportional to the severity of coronary atherosclerosis. They are, however, related to the infarct size, to the inflammatory reaction and to the prothrombotic phase.(ABSTRACT TRUNCATED AT 250 WORDS)..
  74. ncbi Human recombinant alpha 2-HS glycoprotein is produced in insect cells as a full length inhibitor of the insulin receptor tyrosine kinase
    L Kalabay
    3rd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary
    Horm Metab Res 30:1-6. 1998
    ..1)...
  75. ncbi [Specific treatment of the acute cerebral infarct. Present and future]
    J J Muñoz-Torrero
    Servicio de Neurologia, Unidad de Ictus, Hospital Universitario La Paz, Universidad Autonoma de Madrid, Madrid, Espana
    Rev Neurol 31:959-82. 2000
    ..Studies therefore are still being done. In future their use in combination with thrombolysis may be considered...
  76. ncbi Routine o-glycan characterization in nutritional supplements--a comparison of analytical methods for the monitoring of the bovine kappa-casein macropeptide glycosylation
    N T Tran
    Laboratoire de Chimie Analytique, , , France
    J Chromatogr A 929:151-63. 2001
    ..In conclusion, a combination of electrophoretic and chromatographic techniques was found powerful in studying glycoprotein heterogeneity and assessing batch-to-batch consistency...
  77. ncbi Complement-mediated lysis and infectivity for mouse macrophages and sandflies of virulent and attenuated Leishmania major promastigotes varying in expression of the major surface protease and lipophosphoglycan
    M Camara
    , Facultad de Medicina, Universidad de Murcia, Spain
    Ann Trop Med Parasitol 89:243-51. 1995
    ..A very elongated LPG could be necessary for the survival and proliferation of the parasite in macrophages...
  78. ncbi Expression of functionally P-glycoprotein in MA104 kidney cells
    M A Capella
    , , Universidade Federal do Rio de Janeiro, Brazil
    Z Naturforsch C 54:119-27. 1999
    ..The results taken together suggest that MA104 cells intrinsically have a high expression of functionally P-glycoprotein in their membranes...
  79. ncbi Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces cerevisiae
    G Conseil
    Laboratoire de Biochimie Structurale et Fonctionnelle, Institut de Biologie et Chimie des Prot eines, UPR 412 du Centre National de la Recherche Scientifique, Lyon, France
    Biochemistry 39:6910-7. 2000
    ..In contrast, inhibition of either ATP or UTP hydrolysis occurred at much higher concentrations and appeared to be noncompetitive. Prenyl-flavonoids therefore behave as potent inhibitors of drug binding to the yeast Pdr5p ABC transporter...
  80. ncbi The c-erbA beta thyroid hormone receptor. Expression and cDNA sequence analysis of the hormone-binding domain in human cancer cell lines
    V T Chow
    Department of Microbiology, Faculty of Medicine, National University of Singapore, Kent Ridge
    Acta Oncol 33:499-505. 1994
    ..Sequencing of an aberrant fragment fortuitously amplified from the HT-1080 cDNA library demonstrated concordance with the cDNA of pregnancy-specific glycoprotein 4, which is related to the tumour marker, carcinoembryonic antigen...
  81. ncbi [Study on lymphocyte-response in early stage of respiratory infection--a view point from experimental Klebsiella pneumoniae pneumonia]
    H Watanaba
    First Department of Internal Medicine, Kyorin University School of Medicine
    Kansenshogaku Zasshi 66:696-708. 1992
    ..4. Accumulation of B220:Ly5-LFA1 cell in BALF was not observed in significant difference between the mature group and in the juvenile one...
  82. ncbi A sheep hydatid cyst glycoprotein as receptors for three toxic lectins, as well as Abrus precatorius and Ricinus communis agglutinins
    A M Wu
    Glyco Immunochemistry Research Laboratory, Institute of Molecular and Cellular Biology, Kwei San, Taiwan
    Biochim Biophys Acta 1243:124-8. 1995
    ....
  83. ncbi Porcine platelet antigens recognized by human xenoreactive natural antibodies
    J L Platt
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710
    Transplantation 57:327-35. 1994
    ....
  84. ncbi The hsp150 delta-carrier confers secretion competence to the rat nerve growth factor receptor ectodomain in Saccharomyces cerevisiae
    M Simonen
    Institute of Biotechnology, University of Helsinki, Finland
    Yeast 12:457-66. 1996
    ..The hsp150 delta-carrier may have potential in the production of mammalian proteins, which require elaborate folding and disulphide formation in the ER...
  85. ncbi Dual regulation by heat and nutrient stress of the yeast HSP150 gene encoding a secretory glycoprotein
    P Russo
    Institute of Biotechnology, University of Helsinki, Finland
    Mol Gen Genet 239:273-80. 1993
    ..The HSP150 mRNA level was increased by nitrogen limitation at 24 degrees C, even when under the control of a HSP150 promoter region of 137 bp carrying the mutagenized HSE...
  86. ncbi [3H]tyrosine binding to plasma membrane preparation of rat corpora lutea
    E W Gao
    Department of Physiology, Harbin Medical University
    Sci Sin B 31:1454-66. 1988
    ..It is suggested that the high affinity binding sites might be regarded as "tyrosine receptors" and the low affinity ones glycoprotein carriers for tyrosine across the plasma membrane...
  87. ncbi New mechanisms of hormone secretion: MDR-like gene products as extrusion pumps for hormones?
    K F Becker
    Department of Physiology, University of Munich, Germany
    Horm Metab Res 24:210-3. 1992
    ..If so, the cellular export of hormones by active pumps may represent a new mechanism of hormone secretion...
  88. ncbi Granulomatous slack skin in childhood
    F M Camacho
    Department of Medical-Surgical Dermatology, Hospital Universitario Virgen Macarena, Universidad de Sevilla, Spain
    Pediatr Dermatol 14:204-8. 1997
    ..The lymphoid cells showed the following immunophenotype: CD43+ (MT1), CD45+, CD45RO+, CD20-. The phenotype of the giant cells was lysozyme positive, CD68+ and Mac387-...
  89. ncbi Release of proteins and polysaccharides from the albumen gland of the freshwater snail Helisoma duryi: effect of cAMP and brain extracts
    F Morishita
    Zoological Institute, Faculty of Science, Hiroshima University, Higashi, Japan
    J Comp Physiol A 182:817-25. 1998
    ..These results suggest that a brain peptide promotes the secretion of perivitelline fluid, and this is mediated by the adenylate cyclase/cAMP signal transduction pathway...
  90. ncbi The influence of continuous sliding and subsequent surface wear on the friction of articular cartilage
    H Forster
    School of Mechanical Engineering, University of Leeds, UK
    Proc Inst Mech Eng H 213:329-45. 1999
    ..Although laser profilometry did reveal surface wear which was consistent with a small increase in friction, the primary variable controlling the friction coefficient was the period of loading...
  91. ncbi Chum salmon (Oncorhynchus keta) stanniocalcin inhibits in vitro intestinal calcium uptake in Atlantic cod (Gadus morhua)
    K Sundell
    Department of Zoophysiology, , Sweden
    J Comp Physiol B 162:489-95. 1992
    ..5% and 22.4% at doses of 2.2 and 10.9 nM stanniocalcin, respectively. The results establish the intestine as a target organ for stanniocalcin in marine teleosts...
  92. pmc Foreign glycoproteins expressed from recombinant vesicular stomatitis viruses are incorporated efficiently into virus particles
    M J Schnell
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 93:11359-65. 1996
    ..Recombinant VSVs carrying foreign antigens on the surface of the virus particle may be useful for viral targeting, membrane protein purification, and for generation of immune responses...
  93. ncbi Platelet antibodies in patients with migraine
    M Schabet
    , , Germany
    Headache 38:472-4. 1998
    ..We can not exclude the occurrence of antibodies against neuron-specific serotonin receptors...
  94. pmc A heat shock gene from Saccharomyces cerevisiae encoding a secretory glycoprotein
    P Russo
    Institute of Biotechnology, University of Helsinki, Finland
    Proc Natl Acad Sci U S A 89:3671-5. 1992
    ..Disruption of HSP150 did not lead to inviability or significant effects on growth rate, mating, or thermotolerance. However, heat-regulated antigenic homologs of HSP150 were found in divergent yeasts such as Schizosaccharomyces pombe...
  95. ncbi [Contribution of the vascular interstitial matrix to induced contraction by angiotensin II. In vitro studies on the rabbit aorta, mesenteric artery and vein]
    G E Plante
    , , , Canada
    Arch Mal Coeur Vaiss 89:997-1001. 1996
    ..Correction of the abnormality by calcium enrichment of the Krebs solution suggests that a relative diminution and/or a redistribution of this important cation, obtained following the interstitial degradation of hyaluronan...
  96. ncbi Direct injection of large volumes of plasma/serum on a new biocompatible extraction column for the determination of atenolol, propranolol and ibuprofen. Mechanisms for the improvement of chromatographic performance
    J Hermansson
    ChromTech, , Sweden
    J Chromatogr A 797:251-63. 1998
    ..Linear calibration graphs were obtained and the r values were > or = 0.9999...
  97. ncbi Expression of cell surface glycoprotein CD44 and integrins in breast cancers among Indian women
    M M Menon
    Department of Immunology, Breach Candy Medical Research Centre, Bombay, India
    Tumori 84:589-94. 1998
    ..The reverse was true for non-Parsis. The deviation from the general pattern needs further study based on a large number of samples and appropriate use of splice variants...
  98. ncbi Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas
    S Vidal
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Canada
    Ultrastruct Pathol 23:141-8. 1999
    ..The enhanced susceptibility to develop plurimorphous adenomas of the acidophil cell line may have a genetic basis in the stable population the patients came from...
  99. ncbi Immunohistochemical features of giant cell carcinoma of the lung: patterns of expression of cytokeratins, vimentin, and the mucinous glycoprotein recognized by monoclonal antibody A-80
    G Chejfec
    Department of Pathology, Hines VA Hospital Loyola University School of Medicine, Maywood, Illinois
    Ultrastruct Pathol 15:131-8. 1991
    ..Findings indicate that all GCCL are indeed cytokeratin positive but that most express polypeptides toward the low-molecular weight end of the spectrum; a small subset also expresses heavier polypeptides.(ABSTRACT TRUNCATED AT 250 WORDS)..
  100. ncbi Examination of capillary zone electrophoresis, capillary isoelectric focusing and sodium dodecyl sulfate capillary electrophoresis for the analysis of recombinant tissue plasminogen activator
    J M Thorne
    Northeastern University, Barnett Institute, Boston, MA, USA
    J Chromatogr A 744:155-65. 1996
    ..Finally, the potential of SDS capillary electrophoresis using a coated capillary for an rtPA Type I/Type II purity assay was shown...
  101. ncbi [Analysis of lymphocyte populations with flow cytometry in routine bronchoalveolar lavage diagnosis: comparison of a 3-color method with the alkaline phosphatase anti-alkaline phosphatase immunohistochemistry]
    M Bergmann
    ,
    Pneumologie 51:860-4. 1997
    ..FCM-analysis was performed with the following panel of conjugates: CD3-FITC, CD4- or CD8-PE, CD45-perCP. Lymphocytes were gated by their SSC/CD45 characteristics...

Research Grants84

  1. P-glycoprotein Function in Allograft Rejection
    Markus Frank; Fiscal Year: 2004
    ....
  2. Impact of genetic variation on response to GO therapy in COG-AML clinical trials
    ROLAND BRUNO WALTER; Fiscal Year: 2013
    ..Moreover, this research will provide novel insights into the impact of genetic polymorphisms on efficacy of standard therapeutics with broad implications for the treatment of AML. ..
  3. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..In addition, our studies will measure the magnitude of such interactions. The results of our study should lead to better management of drug therapy and improvement of the drug development process. ..
  4. Davide Trotti; Fiscal Year: 2015
    ..In this application we propose to study the regulation and role of these ABC transporters in ALS. Our ultimate goal is to understand the pathogenic mechanisms of ALS to improve the chances of success of pharmacotherapy for this disease. ..
  5. Kenneth A Krohn; Fiscal Year: 2015
    ..abstract_text> ..
  6. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
    ..Daphnicyclidin A. This recent discovery has revealed a new molecular architecture which exhibits significant antitumor activity. Our research will investigate strategies for chemical synthesis of these complex polycyclic systems. ..
  7. Hong Gang Wang; Fiscal Year: 2016
    ..Importantly, we have documented engraftment in NSG mice of AML subsets defined by integrated genetic profiling. ..
  8. Hans Schreiber; Fiscal Year: 2016
    ..With these antibodies, we will make additional CARs (and fusions proteins) to be used in combination with 5E5 to prevent tumor escape. ..
  9. Vijay Sharma; Fiscal Year: 2015
    ..Successful execution of the outlined objectives should provide a molecular-targeted 68Ga-PET agent for MPI and management of CAD. ..
  10. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..abstract_text> ..
  11. Jessica L Mega; Fiscal Year: 2014
    ..The TIMI Study Group also offers the appropriate training environment to provide Dr. Mega with the skills needed to lead the multicenter clinical trial described in Aim 3. ..
  12. Functions of MRP2 and MRP3 in Drug Disposition
    James M Gallo; Fiscal Year: 2011
    ..These improvements could potentially allow the drugs to be given by mouth instead of intravenously, and also reduce the side effects that are associated with the way the body disposes of anticancer agents. ..
  13. Medications Development for the Pregnant Opiate Addict
    Mahmoud S Ahmed; Fiscal Year: 2010
    ..abstract_text> ..
  14. Novel mycobacterial translocase I inhibitors - a new class of anti-TB drugs
    Venkata M Reddy; Fiscal Year: 2010
    ..abstract_text> ..
  15. Identification of Lactobacillus Secreted Factors in Regulation of Pgp
    Seema Saksena; Fiscal Year: 2013
    ..Since using live bacteria could be a potential risk in the treatment of gut disorders, using secreted bioactive factor (s) instead of live bacteria would lead to an innovative approach for their therapeutic usage. ..
  16. Designing HIV Protease Inhibitors with Lower Dosing Requirements and Lower Toxici
    Mitchell W Mutz; Fiscal Year: 2013
    ..By reducing the toxicity of HIV protease inhibitors, we hope to improve compliance with HAART and therapeutic outcomes. ..
  17. Margaret S Bynoe; Fiscal Year: 2016
    ....
  18. THOMAS PAUL DAVIS; Fiscal Year: 2014
    ..This study may point to novel ways to improve CNS opioid delivery and to avoid unwanted opioid side effects during the treatment of pain. ..
  19. Diffraction Methods in Molecular Biology Gordon Research Conference
    NANCY RYAN GRAY; Fiscal Year: 2010
    ..The 2010 Gordon Research Conference in Diffraction Methods in Structural Biology seeks to advance the techniques used in structure determination by providing a forum for the presentation and discussion of recent developments. ..
  20. Herb-Drug Glucuronidation Interactions
    Reginald F Frye; Fiscal Year: 2011
    ....
  21. Tatiana Nanovskaya; Fiscal Year: 2015
    ..In summary, The information obtained is necessary for evaluating bupropion as a potential medication for aiding in smoking cessation during pregnancy. ..
  22. St. John's wort for Drug Abuse Treatment During Pregnancy
    C LINDSAY LINDSAY DEVANE; Fiscal Year: 2012
    ..The results will be a test of a novel pharmacological strategy for treatment of pregnant women with opioid dependence/addiction. ..
  23. John R Ohlfest; Fiscal Year: 2014
    ..Improving drug delivery could lead to improved patient outcomes, including longer progression free survival and possible cure. ..
  24. Genomic and Cellular Markers and Chronic Renal Allograft Function
    Kathleen M Tornatore; Fiscal Year: 2010
    ....
  25. Studies on a Novel Taxane Pump
    Elizabeth Hopper-Borge; Fiscal Year: 2011
    ..The goal of this proposal is aimed is to obtain information about one of these recently identified proteins. ..
  26. The Role of P-glycoprotein in Sitagliptin Clinical Pharmacology
    Christina L Aquilante; Fiscal Year: 2010
    ..e., clinical pharmacology). The aims of this application are to investigate the clinical pharmacology of sitagliptin in order to promote its safe and effective use in patients with type 2 diabetes. ..
  27. Susan L Mooberry; Fiscal Year: 2015
    ....
  28. Duane D Miller; Fiscal Year: 2016
    ....
  29. Anika M S Hartz; Fiscal Year: 2015
    ....
  30. William M Atkins; Fiscal Year: 2014
    ..Such studies could lead to conformation-specific inhibitors of P-gp with utility in the modulation of pharmacokinetic properties of existing drugs. ..
  31. Development of Dual GABAA and alpah7 Nicotinic Receptor Modulators for AD
    Kelvin W Gee; Fiscal Year: 2013
    ..abstract_text> ..
  32. IMAGING FUNCTIONAL P-GLYCOPROTEIN TRANSPORT AT THE BBB IN ALZHEIMER'S DISEASE
    Vijay Sharma; Fiscal Year: 2011
    ....
  33. Drug Transporters and the Disposition of ADHD Therapeutic Agents
    John S Markowitz; Fiscal Year: 2010
    ....
  34. DRUG INTERACTIONS
    ALLAN EDWARD RETTIE; Fiscal Year: 2012
    ..abstract_text> ..
  35. THOMAS PAUL DAVIS; Fiscal Year: 2016
    ....
  36. Gavril W Pasternak; Fiscal Year: 2016
    ..abstract_text> ..
  37. Sammanda Ramamoorthy; Fiscal Year: 2016
    ..This translational research will promote more informed decisions regarding fetal risk from psychoactive drug use during pregnancy. ..
  38. Effects of Anthocyanins on Cytochrome P450 Enzymes and P-glycoprotein
    MICHAEL JOHN HANLEY; Fiscal Year: 2012
    ....
  39. Curcumin and Piperine in Breast Cancer Prevention
    Madhuri Kakarala; Fiscal Year: 2011
    ....
  40. Michal Toborek; Fiscal Year: 2015
    ....
  41. Structural biology and high resolution studies of P-glycoprotein
    GEOFFREY A CHANG; Fiscal Year: 2013
    ..The structures of Pgp should greatly facilitate the development of new drugs to circumvent multidrug resistance in the future. ..
  42. Chengguo Xing; Fiscal Year: 2016
    ..Aim 3. To validate the anticancer selectivity and mechanism of action for CXL positive lead against drug resistant AML in engraftment models. ..
  43. Amos B Smith; Fiscal Year: 2016
    ..The mechansim of action of another Taxol-like drug, discodermolide will be determined and different structural analogs will be tested for improved chemotherapeutic activity. ..
  44. Understanding polyspecific drug binding in P-glycoprotein
    Ina L Urbatsch; Fiscal Year: 2012
    ..By learning more about how Pgp recognizes the chemicals that it carries out of the cell, scientists may devise new drugs to prevent Pgp from interfering with the valuable effects of anticancer drugs. ..
  45. P-glycoprotein and Alzheimer's Disease
    Jashvant D Unadkat; Fiscal Year: 2010
    ..These proposed studies have the potential to result in identification of P-gp as a novel therapeutic target for the treatment of AD, a disease for which no effective therapy exists. ..
  46. Structural Biology and Inhibition of MDR ABC Transporters
    Geoffrey Chang; Fiscal Year: 2009
    ..4. Structural studies of MsbA with cyclic inhibitors based on cyclosporin A and other MDR cyclopeptides (Class II MsbA inhibitors). 5. Structural studies of a new MDR-ABC transporter from H. Influenza. ..
  47. P-GLYCOPROTEIN MEDIATED CHEMORESISTANCE IN ALS THERAPY
    Davide Trotti; Fiscal Year: 2010
    ....
  48. ROLE OF ATP-BINDING CASSETTE TRANSPORTERS IN INNATE INTESTINAL DEFENSE
    Brien Neudeck; Fiscal Year: 2007
    ..Once this is accomplished, we can use this information to develop protective strategies that exploit these preexisting barriers to L. monocytogenes and potentially other pathogens. [unreadable] [unreadable] [unreadable]..
  49. HUMAN MULTIDRUG RESISTANCE (P GLYCOPROTEIN) GENES
    IGOR RONINSON; Fiscal Year: 1999
    ....
  50. MULTIDRUG RESISTANCE AND P-GLYCOPROTEIN IN HUMAN CANCER
    Victor Ling; Fiscal Year: 1992
    ..We believe that accomplishment of the specific aims described in this application will add significantly to our knowledge of malignant development and therapeutic efficacy in human cancer...
  51. Stuart J Frank; Fiscal Year: 2014
    ..The knowledge gained and the development of inhibitory anti-GH receptor monoclonal antibodies as potential therapeutics may have broad relevance in our understanding of normal physiology and in treatment of cancer. ..
  52. Synthesis of MUC1 glycopeptides and generation of antibodies for the indentificat
    Katja Michael; Fiscal Year: 2011
    ..It is our goal to develop the tools, a set of monoclonal antibodies, which can specifically identify these cell surface glycopeptide epitopes. ..
  53. James M Binley; Fiscal Year: 2016
    ..We will use a new strategy to produce VLPs bearing only authentic Env trimers. By similar methods, we will generate fully authentic soluble Env trimers. Their ability to elicit nAbs will be compared to mock immunogens. ..
  54. Modulation of MUC1 Mucin Trafficking
    Rebecca P Hughey; Fiscal Year: 2010
    ..Our success in these studies will provide novel and fundamental insights into both MUC1-dependent signaling and mislocalization in tumors, which will contribute to a new level of understanding of MUC1 biology in human cancer. ..
  55. Biosynthesis and function of base J in T. brucei
    Robert S Sabatini; Fiscal Year: 2011
    ..These studies may prove useful in identifying novel approaches to prevention, treatment and diagnosis of the debilitating and deadly diseases caused by these parasites. ..
  56. A novel glycosylation-associated protein is required for fimbriae biogenesis
    Haley L Echlin; Fiscal Year: 2013
    ..To test this hypothesis, I propose to investigate these specific aims: 1) assess the biochemical function of Gap2;2) analyze Gap2 interaction with other proteins in the Fap1 cluster;3) determine the role Gap2 plays in Fap1 biogenesis. ..
  57. Activation Defects in T Cells of Aged Mice
    Richard A Miller; Fiscal Year: 2011
    ..In addition, OSGE, a protease specific for O-linked glycoproteins including CD43, CD44, and CD45, has been shown to restore function of aged T cells to levels similar to that of T cells of young donors...
  58. Barbara Imperiali; Fiscal Year: 2015
    ....
  59. Geert Jan Boons; Fiscal Year: 2016
    ..The importance of ligand density, surface attachment methodology, and nature of the solid surface will be investigated in detail. ..
  60. In-process glycoprofiling during recombinant therapeutic glycoprotein production
    Loretta Yang; Fiscal Year: 2012
    ....
  61. Development of a Recombinant Subunit Vaccine for CCHF
    David E Clements; Fiscal Year: 2013
    ..The successful development of a CCHF recombinant subunit vaccine based on this platform supports the concept that a single platform can be utilized to produce vaccines against a number of viral priority pathogens. ..
  62. Michael R King; Fiscal Year: 2014
    ..The simulation will be first applied to the clinical investigation and diagnosis of hereditary bleeding disorders, and in the future will enable phenotype prediction of patients treated with anticoagulants such as aspirin and Plavix. ..
  63. Bibo Li; Fiscal Year: 2016
    ..Identification of novel factors involved in antigenic variation also provides more potential targets for anti-parasite drugs and helps for eventual elimination of this parasite. ..
  64. CD45 Pretargeted Radioimmunotherapy for AML
    Oliver W Press; Fiscal Year: 2013
    ..In this project, we plan to improve the cure rate of AML by targeting radionuclides to the CD45 antigen expressed on AML...
  65. BRENDA MARIE SANDMAIER; Fiscal Year: 2016
    ..relapsed myeloid diseases, but have not been tested in regimens for NHL even though >95% of NHL express the CD45 antigen. We have recently begun exploring 131I-anti-CD45 MAb to improve outcomes for relapsed NHL patients in the ..
  66. Bispecific Antibody Engineering for AML RIT
    Oliver W Press; Fiscal Year: 2013
    ..Aim 2, we will assess the binding characteristics of anti-CD45 x anti-ligand bispecific Abs (scFv2-iFabs) for CD45 antigen and for radiometal ligand chelates in vitro...
  67. Oliver W Press; Fiscal Year: 2015
    ..and lymphomas by targeting radionuclides to neoplastic cells using monoclonal antibodies (Ab) directed at the CD45 antigen present on the surface of these malignancies...
  68. Michael Demetriou; Fiscal Year: 2014
    ..The lattice also binds and localizes the tyrosine phosphatase CD45 to GEMs and the immune synapse, thereby suppressing Lck activity and TCR signaling...
  69. GENETIC ANALYSIS OF REGULATION AND FUNCTION OF CD45
    William Raschke; Fiscal Year: 2002
    The leukocyte common antigen CD45 has received considerable attention recently as evidence accumulates for its role in signal transduction during immune responses...
  70. ASIM AMINSHARIF AHMED; Fiscal Year: 2015
    ..Children's Hospital Boston is committed to this career development plan and has assured the candidate will be able to devote at least 85% full-time effort to the activities described in this proposal. ..
  71. Function and pharmacology of schistosome multidrug resistance proteins
    Robert M Greenberg; Fiscal Year: 2010
    ..We propose to use several approaches to determine the properties of one such schistosome molecule, P-glycoprotein, which, in vertebrates, is also involved in resistance to a broad array of drugs. ..
  72. WI State Public Health Lab Capacity for SCID Screening
    CHARLES DENNIS BROKOPP; Fiscal Year: 2010
    ..both on the initial DBS), a second whole blood specimen is assessed by flow cytometry (CD3, CD4, CD8, CD19, CD56, CD45 and CD45RO);low counts warrant immediate referral and assessment at the Immune Deficiency Clinic at CHW...
  73. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..coli lipopolysaccharide. We are interested in identifying the transport proteins that catalyze lipid flipping in yeast and mammals and understanding how they work. ..
  74. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 2002
    ..abstract_text> ..
  75. MODULATION OF MULTIDRUG RESISTANCE BY CYCLOSPORIN A
    Charles Erlichman; Fiscal Year: 1992
    ..The proposed studies will evaluate the importance of P-glycoprotein in clinical resistance to MDR and determine whether cyclosporin A can reverse the MDR phenotype in patients...
  76. HUMAN MULTIDRUG RESISTANCE--PGLYCOPROTEIN GENES
    IGOR RONINSON; Fiscal Year: 1992
    ..Finally, protocols for detection of mdrl expression in clinical tumor samples, based on in situ RNA hybridization, will be developed and optimized for clinical studies...
  77. A novel transgenic silkworm system for recombinant glycoprotein production
    Donald L Jarvis; Fiscal Year: 2010
    ..Finally, these results will be of great interest to bioengineers working to overcome the evolutionary limitations of lower eukaryotic systems for recombinant glycoprotein production. ..
  78. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Quentin J Baca; Fiscal Year: 2010
    ..will examine the mobility control mechanisms and molecular associations of the receptor-like tyrosine phosphatase CD45, a key regulator of T cell activation...
  79. Development of transformed lactobacilli as a microbicide
    Richard B Markham; Fiscal Year: 2010
    ....
  80. Immune Tolerance and Autoimmunity
    Abul K Abbas; Fiscal Year: 2010
    ..their roles in preventing lymphoproliferation and maintaining homeostasis. Project 3. Regulation of CD45 signaling in tolerance and autoimmunity (PI: A. Weiss)...
  81. Immunoglobulin CDR-H3 and neutralizing antibodies to HIV
    Harry Schroeder; Fiscal Year: 2009
    ....
  82. IN VIVO/IN VITRO STUDIES OF BONE ACIDIC GLYCOPROTEIN-75
    JEFFREY GORSKI; Fiscal Year: 1991
    ....
  83. T. gondii as a model for investigation of Cryptosporidium glycoprotein antigens
    ROBERTA M O apos CONNOR; Fiscal Year: 2010
    ..Currently there are no vaccines or treatments for this parasite. This study investigates the use of Toxoplasma gondii to study Cp antigens that are candidates for inclusion in a vaccine for cryptosporidiosis. ..