CD41

Summary

Gene Symbol: CD41
Description: integrin subunit alpha 2b
Alias: BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GTA, HPA3, PPP1R93, integrin alpha-IIb, GPalpha IIb, alphaIIb protein, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), platelet fibrinogen receptor, alpha subunit, platelet glycoprotein IIb of IIb/IIIa complex, platelet membrane glycoprotein IIb, platelet-specific antigen BAK, protein phosphatase 1, regulatory subunit 93
Species: human

Top Publications

  1. ncbi Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain
    U P Naik
    Department of Pharmacology, Center for Thrombosis and Hemostasis, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 272:4651-4. 1997
  2. ncbi Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations
    Renhao Li
    Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 300:795-8. 2003
  3. pmc Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling
    Jieqing Zhu
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Blood 110:2475-83. 2007
  4. pmc Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3
    Naohide Watanabe
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 181:1211-22. 2008
  5. pmc The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling
    Tong Lay Lau
    Department of Biochemistry and Molecular Biology, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    EMBO J 28:1351-61. 2009
  6. pmc G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling
    Haixia Gong
    Department of Pharmacology, University of Illinois at Chicago, 835 South Wolcott Avenue, Room E403, Chicago, IL 60612, USA
    Science 327:340-3. 2010
  7. pmc Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force
    Rustem I Litvinov
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Biophys J 100:165-73. 2011
  8. pmc Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3
    Bryan N Kahner
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e34056. 2012
  9. ncbi Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation
    D A Law
    COR Therapeutics, Inc, South San Francisco, California 94080, USA
    J Biol Chem 271:10811-5. 1996
  10. ncbi Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3
    I Knezevic
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 271:16416-21. 1996

Detail Information

Publications348 found, 100 shown here

  1. ncbi Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain
    U P Naik
    Department of Pharmacology, Center for Thrombosis and Hemostasis, The University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 272:4651-4. 1997
    The mechanism by which platelets regulate the function of integrin alphaIIbbeta3 (or GPIIb/IIIa), the platelet fibrinogen receptor, is unknown but may involve the binding of proteins or other factors to integrin cytoplasmic domains...
  2. ncbi Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations
    Renhao Li
    Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 300:795-8. 2003
    ..These results suggest that homomeric associations involving transmembrane domains provide a driving force for integrin activation. They also suggest a structural basis for the coincidence of integrin activation and clustering...
  3. pmc Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling
    Jieqing Zhu
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Blood 110:2475-83. 2007
    ..This defect was rescued by reduction of the disulfide bond. Our results demonstrate that the separation of transmembrane domains is required for integrin outside-in signal transduction...
  4. pmc Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3
    Naohide Watanabe
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 181:1211-22. 2008
    ..Thus, talin recruitment to alphaIIbbeta3 by RIAM mediates agonist-induced alphaIIbbeta3 activation, with implications for hemostasis and thrombosis...
  5. pmc The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling
    Tong Lay Lau
    Department of Biochemistry and Molecular Biology, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    EMBO J 28:1351-61. 2009
    ..The structurally unique, highly conserved integrin alphaIIbbeta3 TM complex rationalizes bi-directional signalling and represents the first structure of a heterodimeric TM receptor complex...
  6. pmc G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling
    Haixia Gong
    Department of Pharmacology, University of Illinois at Chicago, 835 South Wolcott Avenue, Room E403, Chicago, IL 60612, USA
    Science 327:340-3. 2010
    ..We conclude that integrins are noncanonical Galpha13-coupled receptors that provide a mechanism for dynamic regulation of RhoA...
  7. pmc Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force
    Rustem I Litvinov
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Biophys J 100:165-73. 2011
    ..Taken together, these data provide important quantitative and qualitative characteristics of αIIbβ3-fibrinogen binding and unbinding that underlie the dynamics of platelet adhesion and aggregation in blood flow...
  8. pmc Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3
    Bryan N Kahner
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e34056. 2012
    ..Thus, kindlins do not promote initial talin recruitment to αIIbβ3, suggesting that they co-activate integrin through a mechanism independent of recruitment...
  9. ncbi Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation
    D A Law
    COR Therapeutics, Inc, South San Francisco, California 94080, USA
    J Biol Chem 271:10811-5. 1996
    ..The data suggest that tyrosine phosphorylation of an integrin beta subunit may be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin...
  10. ncbi Direct binding of the platelet integrin alphaIIbbeta3 (GPIIb-IIIa) to talin. Evidence that interaction is mediated through the cytoplasmic domains of both alphaIIb and beta3
    I Knezevic
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 271:16416-21. 1996
    ..Although talin has been suggested to act as a linkage protein mediating the attachment of GPIIb-IIIa to actin filaments, direct binding of GPIIb-IIIa to this cytoskeletal protein has not been demonstrated...
  11. ncbi Distinct domains of alphaIIbbeta3 support different aspects of outside-in signal transduction and platelet activation induced by LSARLAF, an alphaIIbbeta3 interacting peptide
    J M Derrick
    University of Memphis, Department of Microbiology and Molecular Cell Biology, TN 38152, USA
    Thromb Haemost 86:894-901. 2001
    ..Furthermore, these studies suggest that not all alphaIIbbeta3-dependent platelet responses require an intact beta3 cytoplasmic tail...
  12. pmc The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling
    Junling Liu
    Department of Microbiology and Molecular Cell Sciences, University of Memphis, Memphis, TN 38152, USA
    Blood 105:4345-52. 2005
    ....
  13. ncbi Integrins and Src: dynamic duo of adhesion signaling
    Sanford J Shattil
    Hematology Oncology Division, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Trends Cell Biol 15:399-403. 2005
    ..Here, the biochemical basis for and biological significance of this integrin-SFK interaction is summarized, and I propose a general mechanism for initiation of outside-in integrin signaling...
  14. ncbi Regulation of integrin alphaIIbbeta3 activation by distinct regions of its cytoplasmic tails
    Yan Qing Ma
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Biochemistry 45:6656-62. 2006
    ..Together, these data provide molecular insights into how distinct regions of the cytoplasmic tails differentially and cooperatively regulate integrin activation...
  15. ncbi Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease
    Thomas J Kunicki
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Thromb Haemost 101:123-33. 2009
    ..03) and plasma von Willebrand Factor antigen levels (p < 0.001), which likely contributes to resistance to the inhibitory effects of ASA in the PFA-100...
  16. pmc Membrane binding of the N-terminal ubiquitin-like domain of kindlin-2 is crucial for its regulation of integrin activation
    H Dhanuja Perera
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Structure 19:1664-71. 2011
    ..These data suggest a membrane-binding function of the ubiquitin-like domain of kindlin-2, which is likely common for all kindlins to promote their localization to the plasma membrane and control integrin activation...
  17. ncbi Tickling the tails: cytoplasmic domain proteins that regulate integrin alphaIIbbeta3 activation
    Tina M Leisner
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Curr Opin Hematol 14:255-61. 2007
    ....
  18. pmc Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets
    Peter Wonerow
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 364:755-65. 2002
    ....
  19. ncbi [From the physiopathology of thrombosis to therapeutic targets]
    P Nurden
    UMR 5533 CNRS, , 33604 Pessac
    Arch Mal Coeur Vaiss 94:1210-7. 2001
    ..Since then, newer strategies involving drugs acting on the fibrinogen receptor (the GPIIb-IIIa complex) or on ADP receptors have evolved largely as a result of the increased knowledge of the biological ..
  20. pmc Dynamics of platelet glycoprotein IIb-IIIa receptor expression and fibrinogen binding. I. Quantal activation of platelet subpopulations varies with adenosine diphosphate concentration
    M M Frojmovic
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    Biophys J 67:2060-8. 1994
    ..that maximal platelet activation with adenosine diphosphate (100 microM ADP) causes rapid expression of all GPIIb-IIIa receptors for fibrinogen (FgR) (< 1-3 s), measured with FITC-labeled PAC1 by flow cytometry...
  21. ncbi [Mechanisms of platelet activation and development of antiplatelet agents]
    J P Cazenave
    INSERM U 311, Strasbourg
    Arch Mal Coeur Vaiss 89:1501-6. 1996
    ..which fix circulating stimuli such as ADP, thrombin and TXA2 and inhibitors of the binding of adhesive proteins such as fibrinogen to the GPIIb-IIIa integrin or of von Willebrand factor to the leucine-rich glycoprotein complex GPIb-V-IX.
  22. ncbi [Inhibitors of GPIIb/IIIa platelet receptors]
    B Chanu
    , ,
    Arch Mal Coeur Vaiss 92:893-902. 1999
    ..The activation of the GPIIb/IIIa receptors which contribute to the formation of the fibrin bridge between two platelets represents the final ..
  23. pmc Regulation of platelet glycoprotein IIb/IIIa (integrin alpha IIB beta 3) function via the thrombin receptor
    A N Giesberts
    Department of Haematology, University Hospital Utrecht, The Netherlands
    Biochem J 309:613-20. 1995
    ..Here we show that the thrombin receptor agonist peptide (TRAP) (SFLLRN; 15 microM) opens almost the same number of GPIIb/IIIa molecules as 0...
  24. ncbi Serine 752 in the cytoplasmic domain of the beta 3 integrin subunit is not required for alpha v beta 3 postreceptor signaling events
    N Kieffer
    Laboratoire Franco Luxembourgeois de Recherche Biomédicale, Center Universitaire Luxembourg, Grand Duchy
    Cell Adhes Commun 4:25-39. 1996
    ..substitution) in the beta subunit cytoplasmic domain of the platelet fibrinogen receptor GPIIb-IIIa (integrin alpha IIb beta 3), causing Glanzmann's thrombasthenia, has been shown to abrogate bidirectional transmembrane ..
  25. ncbi GpIIb/IIIa is the main receptor for initial platelet adhesion to glass and titanium surfaces in contact with whole blood
    Marita Broberg
    Department of Anatomy and Cell Biology, University of Gothenburg, Box 420, SE 405 30 Gothenburg, Sweden
    J Lab Clin Med 139:163-72. 2002
    ..Several different antibodies directed against platelet integrins and receptors (CD9, FcgammaRII, GPIIb/IIIa, vitronectin receptor, GPIb/V/IX) were used in an attempt to block platelet adhesion to the surfaces...
  26. ncbi Immunological comparisons of integrin alpha IIb beta 3 (GPIIb-IIIa) expressed on platelets and human erythroleukemia cells: evidence for cell specific differences
    L K Jennings
    Department of Medicine, University of Tennessee, Memphis, USA
    Blood Cells Mol Dis 22:23-35. 1996
    Platelet glycoprotein IIb-IIIa (GPIIb-IIIa, alpha IIb beta 3) is expressed on the cell surface of the human erythroleukemia (HEL) cell line...
  27. pmc The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation
    Brian G Petrich
    Department of Medicine, UCSD School of Medicine, La Jolla, California 92093 0726, USA
    J Clin Invest 117:2250-9. 2007
    ..that binding of talin to the beta(3) integrin cytoplasmic domain (tail) results in integrin alpha(IIb)beta(3) (GPIIb-IIIa) activation...
  28. ncbi Effects of Ajoene on lymphocyte and macrophage membrane-dependent functions
    E L Romano
    , Caracas, Venezuela
    Immunopharmacol Immunotoxicol 19:15-36. 1997
    ..extracts of garlic that impairs platelet aggregation by inhibiting the functional exposure of platelet integrins GPIIb/IIIa. In vitro, Ajoene is toxic for several tumoral cell lines, and exert an antiproliferative effect on T...
  29. ncbi Simultaneous isolation of platelet factor 4 and glycoprotein IIb-IIIa complex from rabbit platelets, and characterization of specific chicken antibodies to assay them
    Marcelo Larami Santoro
    Laboratory of Pathophysiology, Institute Butantan, Av Vital Brazil, 1500, 05503 900, Sao Paulo SP, Brazil
    J Immunol Methods 284:55-72. 2004
    ..a protocol for the simultaneous purification of rabbit platelet factor 4 (PF4) and platelet glycoprotein IIb-IIIa (GPIIb-IIIa, integrin alpha(IIb)beta(3)) is described...
  30. ncbi [Modern "antiplatelet agents" in unstable angina]
    A Vahanian
    Service de cardiologie, , Tenon, Paris
    Arch Mal Coeur Vaiss 89:1521-6. 1996
    ..Research for new antiplatelet agents has been concentrated on developing molecules which block the GPIIb/IIIa receptors which are the final step of platelet aggregation...
  31. ncbi (alpha)IIb Integrin, a novel marker for hemopoietic progenitor cells
    Catherine Corbel
    Institut Cochin, INSERM U567, Paris, France
    Int J Dev Biol 49:279-84. 2005
    Integrin (alpha)IIb(beta)3 (abbreviated as (alpha)IIb), also known as GPIIb-IIIa or CD41/CD61, is a cell adhesion molecule expressed on cells belonging to the megakaryocytic lineage...
  32. ncbi Membrane-activated form of glycoproteins IIb/IIIa complex on newborn platelets
    Alicja Wasiluk
    Department of Neonatology and Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland
    Fetal Diagn Ther 21:177-80. 2006
    b>GPIIb/IIIa complex is one of the laboratory markers of platelet activation. Closely associated with this process is exposure of the fibrinogen-binding site which is essential for platelets aggregation...
  33. ncbi A Cys374Tyr homozygous mutation of platelet glycoprotein IIIa (beta 3) in a Chinese patient with Glanzmann's thrombasthenia
    C M Grimaldi
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood 88:1666-75. 1996
    ..Immunoblotting of platelet lysates demonstrated decreased levels of GPIIb (approximately 30% to 35% of normal) and GPIIIa (approximately 10% of normal), and the GPIIb had undergone normal ..
  34. ncbi [The best in 2000 on thrombosis]
    E Ferrari
    CHU de Nice, Service de cardiologie, 30, avenue de la Vole-Romaine, 06002 Nice
    Arch Mal Coeur Vaiss 94:69-73. 2001
    ..On the other hand, the electric syringe will continue to be required for the integration of the anti-GPIIB-IIIA for the treatment of unstable angina after the recommendations published concomitantly in the United States ..
  35. ncbi Optimization and validation of chiral high-performance liquid chromatographic method for analysis of a fibrinogen (gpIIb/IIIa) receptor antagonist
    R C Williams
    DuPont Pharmaceuticals Company, Wilmington, DE 19880-0353, USA
    J Chromatogr A 844:171-9. 1999
    ..The proposed method was optimized for mobile phase buffer concentration, organic modifier, and temperature using experimental design. The method was then validated for use in release testing of the roxifiban drug substance...
  36. ncbi [Indications for intravenous GPIIb/IIIa receptor inhibitors in acute coronary syndrome without prolonged ST syndrome]
    O Varenne
    Service de cardiologie, , 46, rue Henri-Huchard, 75877 Paris
    Arch Mal Coeur Vaiss 94:1251-8. 2001
    ..Inhibitors of the GPIIb/IIIa receptors block the final step of platelet aggregation...
  37. ncbi Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells
    Maria Teresa Mitjavila-Garcia
    INSERM U 362, Institut Gustave Roussy, Villejuif 94805, Cedex, France
    Development 129:2003-13. 2002
    ..Surprisingly, the CD41 antigen (alphaIIb integrin, platelet GPIIb), essentially considered to be restricted to megakaryocytes, was found on a large proportion of cells within ..
  38. ncbi A high-throughput biotin-avidin-ELISA for studying expression of platelet membrane glycoproteins and its clinical application
    Youtao Zhang
    Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Key Laboratory of Thrombosis and Haemostasis, Ministry of Health, Suzhou, Jiangsu, China
    Tohoku J Exp Med 222:83-8. 2010
    ..enzyme-linked immunosorbent assay (BA-ELISA) with the monoclonal antibodies (mAbs), 7E3 against the complex of GPIIb and GPIIIa (GPIIb/IIIa), SZ-51 against P-selectin, and SZ-2 against GPIb, respectively...
  39. ncbi A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (alphaIIbbeta3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia-like phenotype
    C Ruiz
    Laboratoire d Immunologie and Laboratoire d Hématologie, Institut de Biologie, Centre Hospitalier Universitaire, Nantes, France
    Blood 98:2432-41. 2001
    ..severely reduced platelet-aggregation response to a series of agonists and approximately 20% of surface-expressed GPIIb-IIIa...
  40. ncbi Identification of an abnormal gene for the GPIIIa subunit of the platelet fibrinogen receptor resulting in Glanzmann's thrombasthenia
    P F Bray
    Department of Medicine, University of California, San Francisco 94143 0128
    Blood 75:881-8. 1990
    The platelet fibrinogen receptor, which is composed of glycoproteins IIb (GPIIb) and IIIa (GPIIIa), belongs to a large family of receptors that participate in a multitude of biologically important adhesive interactions...
  41. ncbi Thrombasthenia with an abnormal platelet membrane glycoprotein IIb of different molecular weight
    S M Jung
    Department of Biochemistry II, Jichi Medical School, Tochigi, Japan
    Blood 71:915-22. 1988
    ..dodecyl sulfate-polyacrylamide gel electrophoresis of her platelets indicates that they contain two types of GPIIb molecules: one with an abnormal mol wt (122 kd, unreduced; 128 kd, reduced) and one with a normal mol wt (128 kd, ..
  42. ncbi Arginyl-glycyl-aspartyl (RGD) epitope of human apolipoprotein (a) inhibits platelet aggregation by antagonizing the IIb subunit of the fibrinogen (GPIIb/IIIa) receptor
    D E Barre
    School of Education, Health and Wellness, Cape Breton University, Sydney, Nova Scotia, Canada
    Thromb Res 119:601-7. 2007
    ..An unknown epitope of apolipoprotein (a) antagonizes fibrinogen binding to agonist-stimulated platelet's fibrinogen (GPIIb/IIIa) receptor yielding lipoprotein (a) mediated decreased platelet aggregation...
  43. ncbi [Pre-hospitalization treatment with Abciximab in the preparation of patients for primary angioplasty in the acute phase of myocardial infarct. Immediate and long-term (one month) results]
    B Glatt
    , Centre Cardiologique du Nord, Saint-Denis
    Arch Mal Coeur Vaiss 92:1301-8. 1999
    ..Stent implantation with antiplatelet drug regimen (aspirin, ticlid) limits these risks. Abciximab (new GPIIb/IIIa receptors inhibitor) reduces PTCA complications rate in the acute coronary syndromes...
  44. ncbi Migration behavior and separation of active components in Glycyrrhiza uralensis Fisch and its commercial extract by micellar electrokinetic capillary chromatography
    G Li
    Department of Chemistry, Lanzhou University, China
    J Chromatogr A 863:105-14. 1999
    ..MECC) method for the separation and determination of five components, glycyrrhizic acid (GA), glycyrrhetinic acid (GTA) and 3,4'-dimethoxy-5-hydroxychalone, fermononetin and isoliquiritigenin, in extracts of Glycyrrhiza uralensis ..
  45. ncbi Regulation of autoimmune anti-platelet antibody-mediated adhesion of monocytes to platelet GPIIb/GPIIIa: effect of armed monocytes and the Mac-1 receptor
    K B Hymes
    New York University Medical School, NY 10016
    Blood 75:1813-9. 1990
    ..interaction was studied by utilization of a specific monoclonal antibody (MoAb) 10E5 to trap and immobilize the GPIIb-GPIIIa complex on microtiter plates...
  46. ncbi Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura
    M Kuwana
    Institute for Advanced Medical Research and the Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Blood 98:130-9. 2001
    It was recently reported that autoreactive CD4(+) T cells to glycoprotein IIb-IIIa (GPIIb-IIIa) mediate antiplatelet autoantibody production in patients with immune thrombocytopenic purpura (ITP)...
  47. ncbi Adhesive and signaling properties of a naturally occurring allele of glycoprotein IIIa with an amino acid substitution within the ligand binding domain-the Pena/Penb platelet alloantigenic epitopes
    R Wang
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA
    Blood 92:3260-7. 1998
    ..Whether these allelic variants of the GPIIb-IIIa complex differ in the ability to interact with the adhesive ligand fibrinogen (Fg) is still unknown...
  48. ncbi Comparison of the effects of desflurane and sevoflurane on the expression of platelet surface glycoproteins in unstimulated and adenosine diphosphate-induced platelets in vitro
    Ahmet Koroglu
    Department of Anesthesiology and Reanimation, Inonu University Faculty of Medicine, Malatya 44315, Turkey
    J Clin Anesth 19:328-33. 2007
    ..alveolar concentration (MAC) desflurane and sevoflurane on the expression of CD42b (glycoprotein [GP] Ib), CD41 (GPIIb), CD61 (GPIIIa), CD62P (P-selectin), and CD63 in both unstimulated and adenosine diphosphate (ADP)-stimulated ..
  49. doi Acquired Glanzmann's thrombasthenia caused by glycoprotein IIb/IIIa autoantibodies of the immunoglobulin G1 (IgG1), IgG2 or IgG4 subclass: a study in six cases
    L Porcelijn
    Immunohematology Diagnostic Services Department, Sanquin Diagnostic Services, Amsterdam, The Netherlands
    Vox Sang 95:324-30. 2008
    ..Covering of the fibrinogen binding site of GPIIb/IIIa results in a moderate-to-severe bleeding tendency.
  50. ncbi Effect of glycoprotein IIb-IIIa receptor antagonism on platelet membrane glycoproteins after coronary stent placement
    M Gawaz
    Medizinische Klinik, Klinikum rechts der Isar and Deutsches Herzzentrum, Technische Universitat Munchen, Germany
    Thromb Haemost 80:994-1001. 1998
    ..platelet membrane glycoproteins of patients with angina who underwent coronary stenting and were treated with the GPIIb-IIIa antagonist abciximab (n=20) or with heparin (n=23) were studied...
  51. ncbi Phosphorylation of human platelet glycoprotein IIIa (GPIIIa). Dissociation from fibrinogen receptor activation and phosphorylation of GPIIIa in vitro
    C A Hillery
    Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill 27599
    J Biol Chem 266:14663-9. 1991
    Glycoprotein IIb-IIIa (GPIIb-IIIa) is the fibrinogen receptor on activated platelets. GPIIIa is phosphorylated in resting platelets and the incorporation of 32Pi increases with platelet activation...
  52. pmc Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family
    J J Calvete
    Instituto de Quimica Fisica, C S I C, Madrid, Spain
    Biochem J 274:63-71. 1991
    ..is the common beta-subunit of the beta 3 subfamily of integrins, which, when associated with glycoprotein IIb (GPIIb), constitutes the receptor for fibrinogen and other adhesive proteins at the platelet surface (the GPIIb-IIIa ..
  53. ncbi Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17
    J P Rosa
    U150 INSERM, Hopital Lariboisiere, Paris
    Blood 72:593-600. 1988
    ..requires the binding of adhesive proteins such as fibrinogen to the heterodimer of membrane glycoproteins IIb (GPIIb) and IIIa (GPIIIa). Human erythroleukemia (HEL) cells synthesize both GPIIb and GPIIIa...
  54. ncbi Molecular cloning and expression of glycoprotein IIb and IIIa
    Yanhong Liu
    Department of Laboratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, P R China
    Mol Biol Rep 34:121-5. 2007
    To amplify the cDNA genes of GPIIb, GPIIIa, then construct the eukaryotic expression carriers of GPIIb and GPIIIa respectively, finally establish CHO cell lines stably expressing GPIIb and GPIIIa.
  55. ncbi Immunohistochemical analysis of beta3 integrin (CD61): expression in pig tissues and human tumors
    A Merono
    Department of Genetic, Spanish Research Council University of Córdoba, Spain
    Histol Histopathol 17:347-52. 2002
    CD61 is a membrane glycoprotein that associates with CD41 (alphaIIb) to form the heterodimeric complex gpIIb/IIIa (CD41/CD61), predominantly expressed in platelets and megakariocytes...
  56. doi Antiaggregatory and proangiogenic effects of a novel recombinant human dual specificity anti-integrin antibody
    R Escher
    Department of General Internal Medicine and Central Haematology Laboratory, University Hospital Berne, Berne, Switzwerland
    J Thromb Haemost 7:460-9. 2009
    ..Cross-reactive ligands with antiaggregatory and proangiogenic effects, both desirable in peripheral vasculopathies, have not yet been described...
  57. ncbi Decreased stability and structural heterogeneity of the residual platelet glycoprotein IIb/IIIa complex in a variant of Glanzmann's thrombasthenia
    P W Modderman
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam
    Br J Haematol 73:514-21. 1989
    ..antibody binding in the presence of divalent cations, the platelets contained about 15% of the normal amount of GPIIb and GPIIIa and only 6% of the normal amount of intact GPIIb/IIIa complex...
  58. ncbi Talin does not associate exclusively with alpha 2b beta 3 integrin in activated human platelets
    G Escolar
    , Barcelona, Spain
    J Lab Clin Med 125:597-607. 1995
    ..that may stabilize connections between cytoplasmic actin and the submembrane portion of glycoprotein IIb-IIIa (GPIIb-IIIa) (alpha 2b beta 3 integrin) in thrombin-stimulated human platelets...
  59. pmc New low-frequency platelet glycoprotein polymorphisms associated with neonatal alloimmune thrombocytopenia
    Julie A Peterson
    Blood Research Institute and Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, Wisconsin 53201 2178, USA
    Transfusion 50:324-33. 2010
    ..Recent reports suggest that maternal immunization against low-frequency, platelet (PLT)-specific glycoprotein (GP) polymorphisms is a more common cause of neonatal alloimmune thrombocytopenia (NATP) than previously thought...
  60. ncbi Platelet alpha-granule and plasma membrane share two new components: CD9 and PECAM-1
    E M Cramer
    INSERM U 348, Hopital Lariboisiere, Paris, France
    Blood 84:1722-30. 1994
    ..CD9 and PECAM-1 thus appear to have an intracellular distribution identical to GPIIb-IIIa, a major aggregation platelet receptor...
  61. ncbi Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates
    N Debili
    Institut National de la Santé et de la Recherche Médicale INSERM U 362, Institut Gustave Roussy, Cedex, France
    Blood 97:2023-30. 2001
    The glycoprotein (Gp) IIb/IIIa integrin, also called CD41, is the platelet receptor for fibrinogen and several other extracellular matrix molecules...
  62. ncbi Recombinant anti-idiotypic antibodies inhibit human natural anti-glycoprotein (GP)IIb/IIIa autoantibodies
    R Escher
    Central Hematology Laboratory, University Hospital, Bern, Switzerland
    J Autoimmun 18:71-81. 2002
    ..We have previously reported on the generation of two recombinant anti-GPIIb/IIIa autoantibody fragments (PDG-X, PDG-B), that are specific for conformationally intact GPIIb/IIIa and inhibit ..
  63. ncbi [Angioplasty in acute myocardial infarction]
    P G Steg
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 92:1627-35. 1999
    ..Recent studies have demonstrated that stents and adjuvant pharmacological therapies, specially GpIIb/IIIa antagonists are associated with improved results...
  64. ncbi Presence of growth factors in palmar and plantar fibromatoses
    R L Zamora
    St Mary s Health Center, Richmond Heights, MO
    J Hand Surg Am 19:435-41. 1994
    ..growth factor-beta, epidermal growth factor, procollagen type 1, fibronectin, phosphotyrosine residues, and CD41 platelet antigen were used in standard immunoperoxidase staining to study 36 nodules and 24 cords obtained from ..
  65. pmc Thrombin promotes platelet-mediated melanoma cell adhesion to endothelial cells under flow conditions: role of platelet glycoproteins P-selectin and GPIIb-IIIA
    R Dardik
    National Hemophilia Center and Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel
    Br J Cancer 77:2069-75. 1998
    ..ECs by TRAP-activated platelets was virtually abolished by blockade of the platelet glycoproteins P-selectin and GPIIb-IIIa by monoclonal antibodies...
  66. ncbi Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of alphaIIbbeta3 integrin (ITGA2B, ITGB3)
    Hava Peretz
    Clinical Biochemistry Laboratory, Sourasky Medical Center, Tel Aviv, Israel
    Hum Mutat 27:359-69. 2006
    ....
  67. ncbi Endogenous platelet fibrinogen surface expression on activated platelets
    H R Gralnick
    Hematology Service, Clinical Center, National Institutes of Health, Bethesda, MD 20892
    J Lab Clin Med 118:604-13. 1991
    ..Studies correlating platelet fibrinogen surface expression with the presence of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex showed that in the presence of ethylene glycol tetraacetic acid (EGTA) at 37 degrees C, neither the ..
  68. pmc Primary arrest of circulating platelets on collagen involves phosphorylation of Syk, cortactin and focal adhesion kinase: studies under flow conditions
    Gemma Arderiu
    Servei d Hemoterapia Hemostasia, Hospital Clinic, Institut de Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Spain
    Biochem J 364:65-71. 2002
    ..occurs through platelet glycoprotein (GP) Ib and collagen receptors; then platelets spread and aggregate through a GPIIb-IIIa-dependent mechanism...
  69. pmc The heptapeptide LSARLAF mediates platelet activation through phospholipase Cgamma2 independently of glycoprotein IIb-IIIa
    Andrew C Pearce
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Biochem J 378:193-9. 2004
    The seven-amino-acid peptide LSARLAF has been reported to activate platelets via the integrin GPIIb-IIIa (glycoprotein IIb-IIIa)...
  70. ncbi [The clinical use of the GPIIb/IIIa inhibitors eptifibatide and tirofiban in the treatment of acute coronary syndromes of the "non-ST elevation" type]
    M Galli
    Divisione di Cardiologia, Fondazione Salvatore Maugeri, IRCCS, Veruno
    Ital Heart J Suppl 1:202-11. 2000
    ..Although the combination of GP IIb/IIIa inhibition and standard doses of unfractionated heparin is associated with an increased risk of major bleeding, such risk can be remarkably reduced adopting simple technical suggestions...
  71. doi AlphaIIbbeta3 integrin: new allelic variants in Glanzmann thrombasthenia, effects on ITGA2B and ITGB3 mRNA splicing, expression, and structure-function
    Vincent Jallu
    Platelet Immunology Laboratory, INTS, Paris, France
    Hum Mutat 31:237-46. 2010
    ....
  72. ncbi Sevoflurane inhibits unstimulated and agonist-induced platelet antigen expression and platelet function in whole blood in vitro
    N A Horn
    Department of Anesthesiology, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Anesthesiology 95:1220-5. 2001
    ..Previous studies have reported conflicting results about the effect of sevoflurane on platelet aggregation. To clarify this point, we investigated the effects of sevoflurane on platelet antigen expression and function in vitro...
  73. ncbi Increased local procoagulant action: a mechanism contributing to the favorable hemostatic effect of recombinant FVIIa in PLT disorders
    Ana Maria Galán
    Hematherapy and Hemostasis Service, Hospital Clinic, Faculty of Medicine, IDIBAPS, Barcelona, Spain
    Transfusion 43:885-92. 2003
    ....
  74. ncbi GPIIb-IIIa antagonist-induced reduction in platelet surface factor V/Va binding and phosphatidylserine expression in whole blood
    M I Furman
    Center for Platelet Function Studies, University of Massachusetts Medical School, Worcester, PA 01655, USA
    Thromb Haemost 84:492-8. 2000
    In addition to inhibition of platelet aggregation, GPIIb-IIIa antagonists may reduce thrombotic events via other mechanisms...
  75. ncbi Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells
    M Kerr
    Department of Oral Biology, University of Florida, Gainesville 32610
    Biochim Biophys Acta 1218:375-87. 1994
    ..This activity is dependent upon the expression of the GTA-kinase (p58) in these cells...
  76. ncbi Facilitated percutaneous coronary intervention (PCI) in patients with acute ST-elevation myocardial infarction: comparison of prehospital tirofiban versus fibrinolysis before direct PCI
    Martin Mockel
    Department of Cardiology, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Int J Cardiol 103:193-200. 2005
    ..It is not clear whether GPIIb/IIIa-blockade or fibrinolysis better facilitates PCI.
  77. ncbi Platelet activation status decreases after menopause
    Jose M Aldrighi
    Heart Institute InCor, University of Sao Paulo Medical School, Rua Afonso de Oliveira Santos 50, 3o andar, CEP 05663 030 São Paulo, SP, Brazil
    Gynecol Endocrinol 20:249-57. 2005
    ..The aim of the study was to investigate the impact of the climacterium (before and after menopause) on platelet activation...
  78. ncbi Characterization of cation-binding sequences in the platelet integrin GPIIb-IIIa (alpha IIb beta 3) by terbium luminescence
    C S Cierniewski
    Department of Biophysics, Medical University in Lodz, Poland
    Biochemistry 33:12238-46. 1994
    The binding of cations to purified GPIIb-IIIa (alpha IIb beta 3) and synthetic peptides corresponding to the potential cation-binding sites within this integrin has been assessed by terbium luminescence spectroscopy...
  79. doi The membrane insertion of helical antimicrobial peptides from the N-terminus of Helicobacter pylori ribosomal protein L1
    Tzong Hsien Lee
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Rd, Clayton, Vic, 3800, Australia
    Biochim Biophys Acta 1798:544-57. 2010
    The interaction of two helical antimicrobial peptides, HPA3 and HPA3P with planar supported lipid membranes was quantitatively analysed using two complementary optical biosensors...
  80. ncbi Evaluation of a GPIIb/IIIa antagonist YM337 in a primate model of middle cerebral artery thrombosis
    S Kaku
    Department of Pharmacology, Hamamatsu University School of Medicine, Japan
    Eur J Pharmacol 345:185-92. 1998
    We compared the antithrombotic effect of anti-GPIIb/IIIa antibody Fab fragment YM337 with that of a thromboxane A2 synthetase inhibitor, sodium ozagrel...
  81. ncbi [Coronary stents]
    M Hamon
    Service des Maladies du Coeur et des Vaisseaux, CHU de Caen
    Arch Mal Coeur Vaiss 92:1551-61. 1999
    ..The anti GPIIb/IIIa molecules and the association of ticlopidine and aspirin are part of the pharmacological environment which ..
  82. ncbi Sodium nitroprusside in patients with compromised left ventricular function undergoing coronary bypass: reduction of cardiac proinflammatory substances
    P Massoudy
    Department of Cardiovascular Surgery, University of Essen, Essen, Germany
    J Thorac Cardiovasc Surg 119:566-74. 2000
    ....
  83. ncbi [Preparation of coated tablets of glycyrrhetic acid-HP-beta-cyclodextrin tablets for colon-specific release]
    Qi Hua Cui
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China
    Zhongguo Zhong Yao Za Zhi 33:2339-43. 2008
    To prepare coated tablets of glycyrrhetinic acid and hydroxypropyl-beta-cyclodextrin (GTA-HP-beta-CYD) inclusion complex tablets for colon-specific release.
  84. ncbi Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454
    Ali Amirkhosravi
    Clinical and Research Laboratories, Florida Hospital Cancer Institute, 2501 N Orange Ave, Suite 786, Orlando, Florida 32804, USA
    Thromb Haemost 90:549-54. 2003
    ..Previous experimental studies have suggested that platelet GpIIb/IIIa may be a therapeutic target...
  85. doi Membrane type sialidase inhibits the megakaryocytic differentiation of human leukemia K562 cells
    Un Ho Jin
    Molecular and Cellular Glycobiology Unit, Department of Biological Science, Sungkyunkwan University, Chunchun Dong 300, Suwon, Kyunggi Do 440 746, South Korea
    Biochim Biophys Acta 1780:757-63. 2008
    ..ganglioside GM3 and reduction of Neu3 by PMA, are linked for the expression of differentiation marker protein, CD41b surface antigen...
  86. pmc The cleaved peptide of the thrombin receptor is a strong platelet agonist
    M I Furman
    Center for Platelet Function Studies, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 95:3082-7. 1998
    ..fibrinogen binding site on the glycoprotein (GP) IIb-IIIa complex; and (iii) fibrinogen binding to the activated GPIIb-IIIa complex...
  87. pmc FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia
    Hana Raslova
    Institut National de la Santé et de la Recherche Médicale U 362, Villejuif, France
    J Clin Invest 114:77-84. 2004
    ..FISH analysis on pre-mRNA and single-cell RT-PCR revealed that FLI1 expression is mainly monoallelic in CD41(+)CD42(-) progenitors, while it is predominantly biallelic in the other stages of megakaryopoiesis...
  88. ncbi The impact of genetic variation in the region of the GPIIIa gene, on Pl expression bias and GPIIb/IIIa receptor density in platelets
    Aisling M O'Halloran
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Br J Haematol 132:494-502. 2006
    ..have suggested that genetic variability in the glycoprotein (GP) IIIa gene modulates expression of platelet GPIIb/IIIa (alpha(2b)beta(3))...
  89. ncbi Gene frequencies of human platelet antigens in the Macedonian population
    M Pavkovic
    Department of Haematology, Faculty of Medicine, University Ss Kiril and Metodij, Skopje, Republic of Macedonia
    Tissue Antigens 67:241-6. 2006
    ..091 for HPA-5b. Results of our study were not significantly different from those reported in the other European studies. Our population displayed the highest frequency for HPA-2b allele (0.148) reported among European population...
  90. doi Using triple antiplatelet therapy in patients with non-ST elevation acute coronary syndrome managed invasively: a cost-effectiveness analysis
    Jaime Latour-Pérez
    Intensive Care Unit, Hospital General Universitario de Elche, Elche, Spain
    Value Health 11:853-61. 2008
    To assess the incremental cost-effectiveness ratio (ICER) of glycoprotein IIb/IIIa (GPIIb/IIIa) inhibitors in patients with non-ST elevation acute coronary syndrome (NSTE-ACS) pretreated with aspirin and clopidogrel undergoing an early ..
  91. doi Low concentration detergent sclerosants induce platelet activation but inhibit aggregation due to suppression of GPIIb/IIIa activation in vitro
    Kurosh Parsi
    Haematology Research Laboratory, St Vincent s Hospital, Sydney, Australia
    Thromb Res 130:472-8. 2012
    ..The aim of this study was to investigate the in vitro effects of detergent sclerosants Sodium Tetradecyl Sulphate (STS) and Polidocanol (POL) on platelet activation and aggregation...
  92. doi LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa
    Yi Kong
    School of Life Science and Technology, China Pharmaceutical University, 24 Tong Jia Street, Nanjing 210009, PR China State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China Electronic address
    J Pharmacol Sci 127:462-6. 2015
    ..Furthermore, the ELISA revealed that LX0702 inhibited fibrinogen binding with GPIIb/IIIa in a dose dependent manner with an IC50 value of 1.26 ± 0.13 μM...
  93. doi Transdifferentiation of erythroblasts to megakaryocytes using FLI1 and ERG transcription factors
    Darin Siripin
    Prof Surapol Issaragrisil, Division of Hematology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Tel 662 419 4448 50, Fax 662 411 2012, E mail
    Thromb Haemost 114:593-602. 2015
    ..of megakaryocytes including morphology, expression of specific genes (cMPL and TUBB1) and a marker protein (CD41)...
  94. pmc Transcriptional Repression of the VC2105 Protein by Vibrio FadR Suggests that It Is a New Auxiliary Member of the fad Regulon
    Rongsui Gao
    Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaTartu University
    Appl Environ Microbiol 82:2819-32. 2016
    ..region of the vc2105 gene, encoding a putative thioesterase, was mapped, and a putative FadR-binding site (AA CTG GTA AGA GCA CTT) was proposed...
  95. doi Two novel copy number variations involving the α-globin gene cluster on chromosome 16 cause thalassemia in two Chinese families
    Lingling Hu
    Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, People s Republic of China
    Mol Genet Genomics 291:1443-50. 2016
    ..Proband A is a coinheritance of β(CD41-42) and αααα(282) and showed severe β-thalassemia intermedia phenotype...
  96. pmc A Conceptual Framework for Graduate Teaching Assistant Professional Development Evaluation and Research
    Todd D Reeves
    Educational Research and Assessment, Northern Illinois University, DeKalb, IL 60115
    CBE Life Sci Educ 15:. 2016
    ..This essay proposes a conceptual framework for biology GTA teaching professional development (TPD) program evaluation and research with three overarching variable categories ..
  97. doi Interferon regulatory factor 5 gene polymorphism in Egyptian children with systemic lupus erythematosus
    A Hammad
    1 Pediatric Nephrology Unit, Department of Pediatrics, Faculty of Medicine, Mansoura University, Egypt
    Lupus . 2017
    ..Haplotype GTA of rs10954213, rs2004640 and rs2280714, respectively, was more frequent in lupus patients in comparison to controls ..
  98. ncbi The Fli-1 proto-oncogene, involved in erythroleukemia and Ewing's sarcoma, encodes a transcriptional activator with DNA-binding specificities distinct from other Ets family members
    L Zhang
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Oncogene 8:1621-30. 1993
    ..Furthermore, we have identified an octanucleotide core sequence that is required in vitro for optimal binding of Fli-1 to the Drosophila E74 target and the promoter sequence of the human GPIIB gene.
  99. ncbi Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction
    V L Serebruany
    Center for Thrombosis Research, Sinai Hospital, Baltimore, MD 21215, USA
    Am Heart J 136:398-405. 1998
    ..Platelets play an important role in the natural history of acute myocardial infarction (AMI)...
  100. pmc Time and force dependence of the rupture of glycoprotein IIb-IIIa-fibrinogen bonds between latex spheres
    H L Goldsmith
    McGill University Medical Clinic, Montreal General Hospital Research Institute, Montreal, Quebec, Canada
    Biophys J 78:1195-206. 2000
    ..shear-induced breakup of doublets of aldehyde/sulfate (A/S) latex spheres covalently linked with purified platelet GPIIb-IIIa receptor, and cross-linked by fibrinogen...
  101. ncbi Integrin alphaIIbbeta3 and its antagonism
    Martin J Quinn
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology NB50, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44195, USA
    Arterioscler Thromb Vasc Biol 23:945-52. 2003
    ..An in-depth understanding of how antagonists engage and influence the function of alphaIIbbeta3 and platelets in the context of the new structural insights may explain its salutary and potential deleterious effects...

Research Grants66

  1. Development of Platelet & Coagulation Activation Assays
    RONALD SHEBUSKI; Fiscal Year: 2001
    ..to develop the technology to determine "early" markers of platelet activation (membrane and soluble P-selectin and GPIIb/lIIa) and coagulation activation (prothrombin fragment 1...
  2. Defining the Role of TREM-Like Transcript-1 in Platelet Aggregation
    A Washington; Fiscal Year: 2009
    ..Clot retraction in platelets is mediated by the CD41/CD61 interaction with its ligand fibrin(ogen)...
  3. Defining the Role of TREM-Like Transcript-1 in Platelet Aggregation
    A Washington; Fiscal Year: 2007
    ..Clot retraction in platelets is mediated by the CD41/CD61 interaction with its ligand fibrin(ogen)...
  4. HOW DOES P24/CD9 FUNCTION IN CELL ADHESION
    Lisa Jennings; Fiscal Year: 1999
    ..or has any functional ties with the b1 integrins and will explore the preliminary finding that CD9 interacts with GpIIb/IIIa...
  5. Postmenopause CHD risk: Platelet genes & hormone therapy
    Paul Bray; Fiscal Year: 2006
    ..between functional polymorphisms of platelet genes and specific cardiovascular therapies (aspirin, statins, and GPIIb-Illa blockers)...
  6. A NOVEL RGD-BINDING MEMBRANE PROTEIN ON BLOOD PLATELETS
    Stephen Lam; Fiscal Year: 1993
    ..b>GPIIb-IIIa is a receptor for these adhesive proteins and binds to peptides containing the RGD sequence...
  7. Novel Chaperone Mechanism for Platelet Disorder
    Zihai Li; Fiscal Year: 2010
    ..Moreover, loss of gp96 causes concurrent reduction of cell surface GPIb but not aIIb[unreadable]3 integrin (GPIIb/IIIa). A variety of small molecule inhibitors are already available for targeting HSP90, including gp96...
  8. Aberrant Platelet Mechanisms in Inherited Human Platelet Function Disorders
    ANGARA KONETI RAO; Fiscal Year: 2010
    ..an inherited thrombocytopenia, impaired platelet responses (including myosin and pleckstrin phosphorylation and GPIIb-llla activation), and a heterozygous mutation in transcription factor CBFA2 (Core-binding factor A2), thereby ..
  9. FLOW/SURFACE EFFECTS ON PLATELET GPIIB-IIIA
    Steven Slack; Fiscal Year: 1992
    ..By means of such carefully controlled studies, they hope to better characterize factors governing blood-foreign material interactions...
  10. STRUCTURAL STUDIES OF PLATELET GPIIB/IIIA ACTIVATION
    JOEL BENNETT; Fiscal Year: 1999
    ..Fibrinogen and von Willebrand factor binding to glycoprotein IIb- IIIa (GPIIb-IIIa) complexes on agonist-stimulated platelets is a prerequisite for platelet aggregation...
  11. Pharmacogenetic Antiplatelet Strategies in CHD Patients
    Glen Cooke; Fiscal Year: 2007
    ..formation of a platelet thrombus, a process that requires the binding of extracellular adhesive ligands to the GPIIb-IIIa receptor on the surface of platelets...
  12. EXAMINATION OF GENDER DIFFERENCES IN GPIIB/IIIA FUNCTION
    Nauder Faraday; Fiscal Year: 2000
    ..Fibrinogen binding to its platelet receptor (GPIIb-IIIa or integrin aIIbB3) is required for aggregation and thrombus formation...
  13. PEPTIDE INHIBITORS OF PLATELET AGGREGATION
    Israel Charo; Fiscal Year: 1990
    ..I of the work will complete development of a solid-phase microtiter plate assay for the binding of fibrinogen to GPIIb-IIIa, and will identify the fibroingen-binding domains on GPIIIa will be tested for their ability to inhibit ..
  14. BIOSYNTHESIS NAD STRUCTURE OF THE FIBRINOGEN RECEPTOR
    Paul Bray; Fiscal Year: 1990
    ..Platelet membrane glycoproteins IIb (GPIIb) and IIIa (GPIIIa) exist as a heterodimeric complex in the platelet membrane and function as the receptor for ..
  15. CELLULAR CONSEQUENCES OF DEFECTIVE IIB AND IIIA GENES
    Paul Bray; Fiscal Year: 1993
    ..of genomic sequences controlling the normal expression of the genes for platelet membrane glycoproteins IIb (GPIIb) and IIIa (GPIIIa), and (2) to analyze the cellular consequences of these defects...
  16. ANGARA KONETI RAO; Fiscal Year: 2016
    ..phosphorylation of pleckstrin and myosin light chain (MLC), decreased PKC- and impaired activation of GPIIb-IIIa. This patient has a heterozygous mutation in RUNX1...
  17. Modulation of integrin function by cytoplasmic signals
    Ulhas Naik; Fiscal Year: 2007
    ..Specific aims of the project are to 1) Study the mechanism of regulation of integrin alphaIIb-beta3 (GPIIb/IIIa) by CIB; 2) Identify the role of Plk3 activity in platelet function; 3) Determine the role of CIB and Plk3 in ..
  18. PHYSICAL FORCES EFFECTS ON PLATELETS
    J Hellums; Fiscal Year: 2000
    ..wall shear stresses cause plasma von Willebrand factor (Vwf) to bind to the platelet glycoprotein (GP) Ib/IX/V and GPIIb-IIIa complexes, and that this binding leads to platelet activation associated with secretion and aggregation...
  19. Development of a novel small molecule, UTL-5g, to treat oxaliplatin-induced throm
    Jiajiu Shaw; Fiscal Year: 2013
    ..For all these studies, when applicable, we will conduct counts/analyses on platelets, WBC, bone marrow and CD41+ megakaryocytes. We will also monitor the injuries on liver and kidney by analyzing AST, ALT, BUN, and creatine...
  20. TRANSPORT CHARACTERISTICS OF PEPTIDE MIMETICS
    RONALD BORCHARDT; Fiscal Year: 2003
    ..g., HIV protease inhibitors, gpIIb/IIIa receptor antagonsits)...
  21. GLYCOPROTEINS IIB AND IIIA IN PLATELETS AND NEUTROPHILS
    Lisa Jennings; Fiscal Year: 1991
    Human platelet glycoproteins IIb and IIIa (GPIIb and GPIIIa) are proteins on the membrane surface which mediate the aggregation of platelets in response to vascular injury...
  22. THE IMMUNOGENICITY OF HUMAN PLATELET PROTEINS
    Thomas Kunicki; Fiscal Year: 1990
    ..In view of the importance of certain membrane glycoproteins (GP) in platelet physiology, particularly GPIb and GPIIb/IIIa, the elucidation and further characterization of those structures which make them immunogenic in man will ..
  23. MOLECULAR BASIS OF PLATELET FUNCTION
    Thomas Kunicki; Fiscal Year: 1992
    ..b>GPIIb-IIIa also functions as an activation-dependent fibronectin (Fn) receptor...
  24. BIOSYNTHESIS AND GENETICS OF GLYCOPROTEINS IIB AND IIIA
    Marc Shuman; Fiscal Year: 1993
    ..characterize structure-function relationships of the platelet cytoadhesive receptor, glycoproteins IIb and IIIa (GPIIb-IIIa). The heterodimer is the primary receptor for fibrinogen, and is critical for normal blood clotting...
  25. INTERACTION OF CELLS WITH POLYMERIZING FIBRIN
    Stefan Niewiarowski; Fiscal Year: 1992
    ..The GPIIIa and 80kDa components bind to insolubilized anti-GPIIb/IIIa monoclonal antibody, which blocks fibrinogen binding to platelets, whereas the 66kDa component does not ..
  26. THE STRUCTURE AND FUNCTION OF PLATELET GPIIB-IIIA
    Edward Plow; Fiscal Year: 2003
    ..These sites will be localized and characterized, and the reactivity of therapeutic GPIIb-IIIa blockers with these two sites will be analyzed...
  27. Development of ex vivo Expanded Megakaryocyte Progenitors for Platelet Recovery F
    Holger Karsunky; Fiscal Year: 2009
    ..peripheral blood stem cell transplants it has been noted that platelet recovery correlates with the number of CD34+CD41+ MKP...
  28. Mary Jackson; Fiscal Year: 2015
    ..Glutaraldehyde (GTA) is the most widely used chemical disinfectant for heat-sensitive medical devices in hospitals worldwide...
  29. JAMEY MARTH; Fiscal Year: 2015
    ..Using AMR-dependent and AMR-independent platelet clearance mechanisms, recombinant NanA neuraminidase and anti-CD41 treatment will similarly establish thrombocytopenia in comparing the outcomes on coagulopathy and mortality during ..
  30. Edward J Smith; Fiscal Year: 2016
    ..Transformative Graduate Education" program that includes courses like "Preparing the Future Professoriate", "GTA Workshop", and "Citizen Scholar Seminar...
  31. Syamal K Datta; Fiscal Year: 2014
    ..Sle mice. The autoimmune Th17 inducers in Lin-c- Kit+CX3CR1- splenocytes were c-Kit+CD41+CD151+ with properties of megakaryocyte (MkP) and/or bipotent megakaryocyte/erythroid progenitors (MEP) of bone ..
  32. DIRECTED DIFFERENTIATION OF ES AND IPS CELLS TO HEMATOPOIETIC STEM CELLS
    Kyunghee Choi; Fiscal Year: 2012
    ..Flk-1+ hemangioblasts were sorted and further differentiated on OP9 cells, we were able to efficiently generate CD41+cKit+CD150+ cells, which have been previously identified as ES derived HSC/progenitors (3)...
  33. Combination Treatment of tPA and Apyrase for Stroke
    Ridong Chen; Fiscal Year: 2011
    ..we will determine whether apyrase therapy is more effective while having lower bleeding risk than aspirin and a GPIIb/IIIa receptor antagonist, in combination with r-tPA for thrombolysis of stroke occlusion...
  34. The Molecular Pathogenesis of Hookworm Anemia
    Michael Cappello; Fiscal Year: 2005
    ..The platelet inhibitor blocks the function of two important platelet integrins, glycoprotein Jib/lila (GPIIb/IIIa) and GPIa/Iia, which mediate platelet binding to fibrinogen and collagen, respectively...
  35. The Molecular Pathogenesis of Hookworm Anemia
    Michael Cappello; Fiscal Year: 2001
    ..ceylanicum, and its mechanism of action will be characterized using in vitro assays of GPIa/IIa and GPIIb/IIIa integrin binding. Using a reproducible animal model of A...
  36. Regulation of GPIIb-IIIa by the platelet cytoskeleton
    Joan Fox; Fiscal Year: 2003
    ..Further, the studies may lead to an increased understanding of key mechanisms involved in integrin-mediated functions such as platelet adhesion and aggregation, wound healing, angiogenesis, inflammation, metastasis, and cell migration. ..
  37. Cell-Selective Liposomal Drug Delivery In Restenosis
    Roger Marchant; Fiscal Year: 2005
    ..cell surface molecules expressed in thrombosis and restenosis: (1) high affinity RGD peptides that bind integrin GPIIb-IIIa on activated platelets; (2) Factor VII-derived peptides that bind tissue factor on stimulated endothelial ..
  38. INTERACTION OF GPIIB-IIIA WITH THE PLATELET CYTOSKELETON
    Stephen Lam; Fiscal Year: 2003
    ..Using this system, we will also investigate the role of integrin-cytoskeleton interaction on "outside-in" signaling through pp60src, pp125FAK and MAP kinase. ..
  39. DETERMINANTS OF CORONARY DISEASE IN HIGH RISK FAMILIES
    Lewis Becker; Fiscal Year: 2001
    ..polymorphisms of candidate genes which may be associated with premature thrombotic CHD events (platelet proteins GPIIB/IIIa[PlA1/A2 and Baka/b] and GPIbB, endothelial nitric oxide synthase, angiotensin converting enzyme, ..
  40. IMMUNOCHEMICAL ANALYSIS OF LIGAND-RECEPTOR INTERACTION
    ANDREW FRELINGER; Fiscal Year: 1990
    ..monoclonal antibody, anti-LIBS1, has been developed which preferentially recognizes ligand-occupied conformers of GPIIb-IIIa and inhibits clot retraction...
  41. MICROVASCULAR FAILURE IN MURINE AND PRIMATE STROKE
    E Connolly; Fiscal Year: 2000
    ..Guided by the results of aim #1 and aim #2 the PI plans to use either an anti-platelet strategy (GPIIb/GPIIIa antagonist) or an anti-adhesion receptor strategy (humanized anti P and E-selectin antibody) to demonstrate ..
  42. Depression, Epinephrine, Serotonin, & Platelet Function
    Dominique Musselman; Fiscal Year: 2005
    ..acute coronary syndromes, but patients with major depression exhibit increased numbers of the functional platelet GPIIb/IIIa receptor, the receptor for fibrinogen and other ligands, and the final common pathway by which platelet ..
  43. The Biology of Zebrafish Hematopoietic Stem Cells
    Robert Handin; Fiscal Year: 2009
    ..repopulation assays using hematopoietic stem cells (HSCs) from the whole kidney marrow of zebrafish carrying the CD41-GFP transgene;2) construct transgenic fish lines using the Gal4/UAS system to study the effect of the Wnt, Notch ..
  44. Platelet Liposomal Drug Delivery--Thrombosis /Restenosis
    Shuwu Wang; Fiscal Year: 2006
    ..we shall focus on the design and development of high affinity Arg-Gly-Asp (RGD)-containing liposomes to platelet GPIIb-llla expressed in thrombosis and restenosis...
  45. PEPTIDE INHIBITORS OF THE PLATELET ADHESION RECEPTOR
    MICHAEL PIERSCHBACHER; Fiscal Year: 1990
    ..distinct receptors for the RGD sequence in fibronectin and vitronectin, whereas in platelets a common receptor (gpIIb/IIIa) binds fibronectin, vitronectin, fibrinogen and vWF...
  46. MECHANISMS OF ARTERIAL THROMBOSIS IN WOMEN
    Paul Bray; Fiscal Year: 1999
    ..e., GPIIb IIIa, resulting in a greater fibrinogen binding in women...
  47. LEUKOCYTE ADHESION RECEPTORS AND THROMBOSIS IN STROKE
    David Pinsky; Fiscal Year: 2006
    ..in murine stroke shows that upregulated expression of leukocyte adhesion receptors (ICAM-1, P- and E-selectin), GPIIb/IIIa-receptor mediated aggregation of platelets, and diminished endogenous fibrinolysis are all contributory...
  48. SPECIALIZED REPRODUCTIVE SCIENCES RESEARCH CENTER
    JAMES CATTERALL; Fiscal Year: 2001
    ..that they regulate testicular gene expression will be expanded into a comprehensive analysis of the interaction of GTA factors, especially GATA-1 and GATA-4, with the inhibin/activins genes in testicular cells...
  49. MEGAKARYOCYTE EXPANSION FROM MOBILIZED PERIPHERAL BLOOD
    Alan Smith; Fiscal Year: 1999
    ..MK output will be assessed by cell morphology, flow cytometry (CD34, CD61, CD41, ploidy), and colony assay...
  50. MOLECULAR BIOLOGY OF CYTOADHESINS--ORAL TISSUE MODEL
    GILBERT WHITE; Fiscal Year: 1990
    ..During cell activation, GPIIb and GPIIIa as one cell bind fibrinogen and contact GPIIb and GPIIIa on another cell to form an adherent complex...
  51. SURFACE AND LIGAND RECEPTOR INTERACTIONS OF VWF
    Roger Marchant; Fiscal Year: 1999
    ..peptide segments of the Al domain and RGDX ligand binding to platelet integral membrane receptors GPIb and GPIIb-IIIa and to collagen or heparinized substrata...
  52. A novel platelet inhibitor from bloodfeeding hookworms
    Michael Cappello; Fiscal Year: 2003
    ..This novel protein is the first naturally occurring compound shown to block the binding of platelet integrins GPIIb/IIIa and GPIa/IIa, the cell surface receptors for fibrinogen and collagen, respectively...
  53. MECHANISM OF ACTIVATION OF PLATELET GPIIB AND GPIIIA
    Jeffrey Smith; Fiscal Year: 2001
    The long term objective of this study is to understand the mechanism of activation of the platelet integrin GPIIb-IIIa. GPIIb-IIIa is key to platelet adhesion and aggregation...
  54. ROLE OF VITRONECTIN IN TUMOR CELL METASTASIS
    RICHARD CHERNY; Fiscal Year: 1992
    ..For example, the alpha/v/beta/5 receptor on lung carcinoma cells binds VN alone, while the platelet glycoprotein GPIIb/IIIa the major receptor for fibrinogen, interacts with von Willebrand factor, fibronectin and VN...
  55. BIOMEDICAL RESEARCH SUPPORT
    HARRY KOSTENBAUDER; Fiscal Year: 1991
    ..Gavras); 2) synthesis of peptides recognized by the platelet (GPIIb-IIIa) and other cell adhesion receptors termed integrins, synthesis of peptides corresponding to the platelet ..
  56. IDENTIFICATION OF TSP RECEPTORS ON HUMAN CELLS
    Martha Aiken; Fiscal Year: 1992
    ..Moreover, TSP associates with the cell surface of thrombasthenic platelets which lack GPIIb-IIIa...
  57. SIGNALING MECHANISM OF PLATELET GLYCOPROTEIN IB/IX
    Xiaoping Du; Fiscal Year: 1999
    ..between GPIb-IX and 14-3-3, second, examine the functions of P29 and how it is modulated by ligand binding to GPIIb-IX, third, characterize and express the phosholipase activity of P29, fourth, characterize the structural basis of ..
  58. STRUCTURE/FUNCTION OF BLOOD PLATELET GPIIB-IIIA
    JOSEPH LOFTUS; Fiscal Year: 1999
    ..Major concerns from last review were about interpreting data from loss-of-function mutation, and the need to establish feasibility of methods that had been proposed. ..
  59. STRUCTURE AND FUNCTION OF PLATELET GPIIB/IIIA
    Virgil Woods; Fiscal Year: 1991
    The platelet GPIIb/IIIa complex is a receptor for several adhesive glycoproteins and has been found to be a prototypic member of a family of Arg-Gly-Asp (RGD)-specific adhesion receptors...
  60. IMMUNOGENICITY OF HUMAN PLATELET PROTEINS
    Thomas Kunicki; Fiscal Year: 1999
    ..In the case of GPIIb/IIIa, many antigenic sequences are present because of its tertiary structure...
  61. MODULATION OF PLATELET FUNCTION BY GPIIB - IIIA CYCLING
    JUNE WENCEL; Fiscal Year: 1999
    ..Adapted from Applicant's Abstract) This application seeks to examine the phenomenon of fibrinogen-bound GPIIb/IIIa internalization and cycling...
  62. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. USE OF TEG TO MONITOR GPIIB/IIIA AT THE BEDSIDE
    Eli Cohen; Fiscal Year: 2001
    ..the modified Thrombelastograph(R) Coagulation Analyzer (TEG(R)) assay to monitor platelet glycoprotein Ilb/IIIa (GPIIb/IIla) receptor blockade in patients being treated with c7E3 Fab provides an equivalent or better assessment of ..
  64. HUMAN PLATELET ACTIVATION AND PHOSPHOLIPID METABOLISM
    SUSAN RITTENHOUSE; Fiscal Year: 2000
    ..This phenomenon has been detected by the GPIIb/IIIa antibody, known as PAC-1. Dr...
  65. REGULATION OF ACINAR CELL PROLIFERATION
    MICHAEL HUMPHREYS BEHER; Fiscal Year: 1999
    ..to elucidate the biological effects of beta 1,4-galactosyltransferase (Gal Tase), and the expression of GTA-K on acinar cell growth response...
  66. ISGS: The Ischemic Stroke Genetics Study
    JAMES MESCHIA; Fiscal Year: 2006
    ..to be tested are the beta fibrinogen gene and genes that code for components of 3 platelet glycoprotein receptors GPIIb/IIIa, GPIb, and GPla...