CD40 ligand

Summary

Gene Symbol: CD40 ligand
Description: CD40 ligand
Alias: CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand, CD40 antigen ligand, CD40-L, T-B cell-activating molecule, T-cell antigen Gp39, TNF-related activation protein, tumor necrosis factor (ligand) superfamily member 5
Species: human

Top Publications

  1. ncbi CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    V Henn
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Nature 391:591-4. 1998
  2. ncbi Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia
    Ziye Sui
    Interdepartmental Program in Neuroscience, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 178:3226-36. 2007
  3. pmc Functional interaction of CD154 protein with α5β1 integrin is totally independent from its binding to αIIbβ3 integrin and CD40 molecules
    Youssef El Fakhry
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, Montreal, Quebec, Canada
    J Biol Chem 287:18055-66. 2012
  4. doi CD40 ligand shedding is regulated by interaction between matrix metalloproteinase-2 and platelet integrin alpha(IIb)beta(3)
    W S Choi
    National Research Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea
    J Thromb Haemost 8:1364-71. 2010
  5. ncbi The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
    A Aruffo
    Bristol Myers Squibb, Pharmaceutical Research Institute, Seattle, Washington 98121
    Cell 72:291-300. 1993
  6. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
  7. ncbi Platelet CD40 ligand (CD40L)--subcellular localization, regulation of expression, and inhibition by clopidogrel
    A Hermann
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Platelets 12:74-82. 2001
  8. ncbi CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism
    Patrick Andre
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 8:247-52. 2002
  9. ncbi Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells
    Anita Challa
    MRC Centre for Immune Regulation and the Institute for Cancer Studies, The University of Birmingham, Birmingham, United Kingdom
    Blood 99:3411-8. 2002
  10. pmc Levels of soluble CD40 ligand (CD154) in serum are increased in human immunodeficiency virus type 1-infected patients and correlate with CD4(+) T-cell counts
    Nikolaos V Sipsas
    Department of Pathophysiology, Laikon General Hospital and School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
    Clin Diagn Lab Immunol 9:558-61. 2002

Detail Information

Publications1036 found, 100 shown here

  1. ncbi CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    V Henn
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Nature 391:591-4. 1998
    b>CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the cytokine TNF-alpha, was originally identified on stimulated CD4+ T cells, and later on stimulated mast cells and basophils...
  2. ncbi Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia
    Ziye Sui
    Interdepartmental Program in Neuroscience, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Immunol 178:3226-36. 2007
    ..To investigate the inflammatory aspects of the disease, we examined the levels of soluble CD40L (sCD40L) in paired samples of plasma and cerebrospinal fluid obtained from 25 HIV-infected individuals...
  3. pmc Functional interaction of CD154 protein with α5β1 integrin is totally independent from its binding to αIIbβ3 integrin and CD40 molecules
    Youssef El Fakhry
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, Montreal, Quebec, Canada
    J Biol Chem 287:18055-66. 2012
    In addition to its classical CD40 receptor, CD154 also binds to αIIbβ3, α5β1, and αMβ2 integrins. Binding of CD154 to these receptors seems to play a key role in the pathogenic processes of chronic inflammation...
  4. doi CD40 ligand shedding is regulated by interaction between matrix metalloproteinase-2 and platelet integrin alpha(IIb)beta(3)
    W S Choi
    National Research Laboratory, Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea
    J Thromb Haemost 8:1364-71. 2010
    b>CD40 ligand (CD40L, CD154) in the circulatory system is mainly contained in platelets, and surface-expressed CD40L on activated platelets is subsequently cleaved by proteolytic activity to generate soluble CD40L (sCD40L)...
  5. ncbi The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome
    A Aruffo
    Bristol Myers Squibb, Pharmaceutical Research Institute, Seattle, Washington 98121
    Cell 72:291-300. 1993
    The prominent role of the CD40 receptor in B cell responses led us to investigate the role of the gp39-CD40 interaction in a group of primary immunodeficient patients with defective antibody production...
  6. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
    ..In addition, the CD40-ligand (CD40-L/CD154), a member of the TNF family, is also expressed more widely than activated CD4+ T cells only...
  7. ncbi Platelet CD40 ligand (CD40L)--subcellular localization, regulation of expression, and inhibition by clopidogrel
    A Hermann
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Platelets 12:74-82. 2001
    ..localization and the regulation of expression of the platelet activation markers CD62P and CD63 with CD40 ligand (CD40L) on the surface of washed human platelets...
  8. ncbi CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism
    Patrick Andre
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 8:247-52. 2002
    b>CD40L, a member of the tumor necrosis factor family of ligands, plays a major role in immune responses via its receptor, CD40. Recently, CD40L has been detected on the surfaces of activated platelets and shown to activate endothelium...
  9. ncbi Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells
    Anita Challa
    MRC Centre for Immune Regulation and the Institute for Cancer Studies, The University of Birmingham, Birmingham, United Kingdom
    Blood 99:3411-8. 2002
    ..Below a normally suicidal threshold number of cells, low picomolar quantities of exogenous CD40 ligand (CD40L/CD154) were found to sustain the clone without the discernible shift in phenotype that accompanies high ..
  10. pmc Levels of soluble CD40 ligand (CD154) in serum are increased in human immunodeficiency virus type 1-infected patients and correlate with CD4(+) T-cell counts
    Nikolaos V Sipsas
    Department of Pathophysiology, Laikon General Hospital and School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
    Clin Diagn Lab Immunol 9:558-61. 2002
    b>CD40 ligand (CD40L or CD154) is a costimulatory molecule expressed mainly on activated CD4(+) T cells...
  11. ncbi CD40L association with protection from severe malaria
    P Sabeti
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Genes Immun 3:286-91. 2002
    b>CD40 ligand (CD40L), a glycoprotein involved in B cell proliferation, antigen presenting cell activation, and Ig class switching, is important in the immune response to infection...
  12. ncbi Platelet-CD40 ligand interaction with melanoma cell and monocyte CD40 enhances cellular procoagulant activity
    A Amirkhosravi
    Clinical and Research Laboratories, Florida Hospital Cancer Institute, Orlando 32804, USA
    Blood Coagul Fibrinolysis 13:505-12. 2002
    ..Activated platelets express and release CD40 ligand (CD40L), which induces endothelial TF expression by ligation to CD40...
  13. pmc Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression
    B JoNell Hamilton
    Departments of Medicine Microbiology and Immunology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Mol Cell Biol 23:510-25. 2003
    The expression of CD154 (CD40 ligand) by activated T lymphocytes plays a central role in humoral and cellular immunity...
  14. ncbi Soluble CD40 ligand plasma levels in lung cancer
    Mario Roselli
    Medical Oncology, Department of Surgery, University Tor Vergata, Rome, Italy
    Clin Cancer Res 10:610-4. 2004
    Tumor-induced platelet activation may cause the release of various cytokines, including CD40 ligand (CD40L)...
  15. pmc The dinucleotide repeat polymorphism in the 3'UTR of the CD154 gene has a functional role on protein expression and is associated with systemic lupus erythematosus
    M J Citores
    Fundacion LAIR, Madrid, Spain
    Ann Rheum Dis 63:310-7. 2004
    To investigate the association of the (CA)n dinucleotide repeat in the 3' untranslated region (3'UTR) of the CD154 gene with systemic lupus erythematosus (SLE), and its functional role in protein expression.
  16. ncbi Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS)
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 151:706-11. 2006
    CD40/CD40L signaling is known to play an important role in immune response. The proteins are expressed in a variety of cell types and ligation causes cells to produce inflammatory cytokines and cellular adhesion molecules...
  17. ncbi Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets
    Jan K Damås
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Immunol 177:2699-706. 2006
    ..1) Patients with ATBF (n = 15) had increased serum levels of soluble CD40 ligand (sCD40L), which decreased during follow-up...
  18. ncbi Increased CD154 expression in uninfected infants born to HIV-positive mothers exposed to antiretroviral prophylaxis
    Maria Fiammetta Romano
    Department of Biochemistry and Medical Biotechnologies, Federico II Medical School, Naples University, Naples, Italy
    Viral Immunol 19:363-72. 2006
    ..In particular, treatment with nucleoside analogs was found to increase CD40 ligand (CD40L; CD154) levels, an inducible molecule expressed on activated T lymphocytes...
  19. ncbi CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
    Strong evidence supports a role for CD40 ligand (CD40L) as marker and mediator of inflammatory diseases such as atherosclerosis...
  20. pmc Association of the microsatellite in the 3' untranslated region of the CD154 gene with rheumatoid arthritis in females from a Spanish cohort: a case-control study
    Trinidad Martin-Donaire
    Fundacion LAIR, Madrid, Spain
    Arthritis Res Ther 9:R89. 2007
    CD40-CD154 interaction is an important mediator of inflammation and has been implicated in T helper type 1-mediated autoimmune diseases including rheumatoid arthritis (RA)...
  21. ncbi Influence of genetic polymorphisms in oxidative stress related genes and smoking on plasma MDA-LDL, soluble CD40 ligand, E-selectin and soluble ICAM1 levels in patients with coronary artery disease
    Takahiro Ueno
    Department of Medicine, Division of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan
    Med Sci Monit 15:CR341-8. 2009
    ..Previous studies have shown that oxidative stress plays an important role in coronary heart disease. Polymorphisms in key enzymes that regulate oxidative stress may play a role in atherogenicity and were investigated in this study...
  22. doi Phosphoinositide 3-kinase mediates CD40 ligand-induced oxidative stress and endothelial dysfunction via Rac1 and NADPH oxidase 2
    M Xia
    Department of Nutrition, School of Public Health, Sun Yat Sen University, Guangzhou, China
    J Thromb Haemost 8:397-406. 2010
    b>CD40 ligand (CD40L) has been implicated as an inducer of reactive oxygen species (ROS) generation in endothelial cells, but definitive evidence for this and the in vivo relevance haves not been demonstrated fully...
  23. doi CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease
    Anna Missiou
    Department of Cardiology, University of Freiburg, Freiburg, Germany
    Thromb Haemost 103:788-96. 2010
    b>CD40L figures prominently in atherogenesis. Recent data demonstrate elevated levels of sCD40L in the serum of patients with the metabolic syndrome (MS)...
  24. doi Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway
    Daniel Yacoub
    Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 30:2424-33. 2010
    b>CD40 ligand is a thromboinflammatory molecule that predicts cardiovascular events...
  25. pmc Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role
    Jianping Huang
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 120:3030-8. 2012
    ..In this study, we showed that an extracellular portion of a membrane-bound ligand of CD40 (soluble CD40 ligand; sCD40L) was significantly elevated in the serum of cancer patients compared with healthy donors...
  26. ncbi Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis
    M H Blotta
    Department of Pediatrics, Stanford University, CA 94305, USA
    J Immunol 156:3133-40. 1996
    ..synthesis, using immobilized mAbs against several T cell surface molecules, including CD3, CD28, and the CD40 ligand (CD40L)...
  27. ncbi Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
    U Korthauer
    Max Planck Gesellschaft, Arbeitsgruppe Immunologie, Universitat Erlangen, Germany
    Nature 361:539-41. 1993
    X chromosome-linked immunodeficiency with hyper-IgM (HIGM1, MIM number 308230) is a rare disorder characterized by recurrent bacterial infections, very low or absent IgG, IgA and IgE, and normal to increased IgM and IgD serum levels...
  28. ncbi Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1
    Udo Bavendiek
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:25032-9. 2002
    ..However, the molecular mechanisms of tissue factor gene expression triggered by CD40 ligand (CD40L) in this cell type remain unknown...
  29. ncbi Upregulation of CD40-CD40 ligand (CD154) in patients with acute cerebral ischemia
    C D Garlichs
    Medical Clinic II, Friedrich Alexander University Erlangen Nuremberg, David Morgenstern Weg 14, 91056 Erlangen, Germany
    Stroke 34:1412-8. 2003
    ..Both can be mediated by the CD40 system. This study investigated whether the CD40 system and related mediators are upregulated in patients with transient ischemic attack (TIA) or stroke...
  30. pmc The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells
    Sebastian A Mikolajczak
    University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 199:1025-31. 2004
    The role of CD40 ligand (CD40L)/CD40 signaling in T cell-dependent B cell differentiation and maturation has been amply documented...
  31. ncbi Prolactin effect on CD69 and CD154 expression by CD4+ cells from systemic lupus erythematosus patients
    K Chavez-Rueda
    Laboratory of Autoimmunity, Immunology Research Unit, Pediatric Hospital, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social IMSS, Mexico, DF
    Clin Exp Rheumatol 23:769-77. 2005
    ..The aim was to explore the role of prolactine (PRL) in the lymphocyte activation process in active and inactive systemic lupus erythematosus (SLE) patients in an in vitro model...
  32. pmc Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154
    He Xu
    Transplantation Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Clin Invest 116:769-74. 2006
    b>CD154 is a cell surface molecule expressed on activated T cells that binds to CD40, an activating molecule on APCs...
  33. doi Critical role of lipid rafts in CD154-mediated T cell signaling
    Youssef El Fakhry
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Hopital Saint Luc, Montreal, Que, Canada H2X 1P1
    Eur J Immunol 40:770-9. 2010
    Although signal pathways triggered via the CD40 molecule are well characterized, those induced via CD154 are less known. This study demonstrates that engagement of CD154 in Jurkat D1...
  34. doi Association between serum levels of soluble CD40/CD40 ligand and organ damage in hypertensive patients
    Ming Yuan
    Department of Cardiology, Xijing Hospital, Xi an Shaanxi, China
    Clin Exp Pharmacol Physiol 37:848-51. 2010
    1. CD40 and CD40 ligand (CD40L) have a critical role in the pathophysiology and risk prediction of coronary artery syndrome, including atherothrombosis and atherosclerosis...
  35. doi CD40 translocation to lipid rafts: signaling requirements and downstream biological events
    Amal Nadiri
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, St Luc Hospital, Montreal, QC, Canada
    Eur J Immunol 41:2358-67. 2011
    ..Its interaction with its ligand, CD154, plays a pivotal role in humoral and cell-mediated immunity...
  36. pmc Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion
    M K Spriggs
    Department of Molecular Biology, Immunex Research and Development Corporation, Seattle, Washington 98101
    J Exp Med 176:1543-50. 1992
    ..A comparison of the efficacy of the hCD40-L and mCD40-L in these assays is presented...
  37. ncbi A T cell-specific enhancer of the human CD40 ligand gene
    Lisa A Schubert
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Biol Chem 277:7386-95. 2002
    We observed that the human CD40 ligand (CD40L) gene 5'-flanking region conferred weak promoter activity in activated CD4 T cells, suggesting that additional regions are required for optimal CD40L gene transcription...
  38. ncbi Analysis of a CD40 ligand dinucleotide microsatellite in multiple sclerosis
    Y Dai
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, S 141 86 Stockholm, Sweden
    Eur J Immunogenet 29:81-5. 2002
    In recent years, numerous reports have described the diverse roles of the CD40-CD40 ligand receptor-ligand pair. The interaction of these two cell-surface molecules regulates both humoral and cell-mediated immune functions...
  39. ncbi Clustering of CD40 ligand is required to form a functional contact with CD40
    Heike Grassme
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 277:30289-99. 2002
    ..We show that clustering of the CD40 receptor depends on reciprocal clustering of the CD40 ligand (gp39, CD154)...
  40. ncbi CD154 (CD40 ligand)
    U Schonbeck
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Int J Biochem Cell Biol 32:687-93. 2000
    b>CD40 ligand, a type II transmembrane protein recently renamed CD154, was originally considered restricted to activated T lymphocytes, functioning as a mediator of T cell-dependent B cell activation, proliferation, and differentiation...
  41. ncbi [Linkage of modified human papillomavirus type 16 E7 to CD40 ligand enhances specific CD8+ T-lymphocyte induction and anti-tumour activity of DNA vaccine]
    Qing yong Wang
    Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 29:584-91. 2007
    ..To develop human papillomavirus (HPV) 16 DNA vaccine for the treatment of HPV16 infection and its related tumors...
  42. pmc Patients with acute coronary syndromes express enhanced CD40 ligand/CD154 on platelets
    C D Garlichs
    Medical Clinic II, Friedrich Alexander University Erlangen Nurnberg, Ostliche Stadmauerstrasser 29, 91054 Erlangen, Germany
    Heart 86:649-55. 2001
    To investigate whether CD40L/CD154 on platelets and soluble CD40L/CD154 may play a role in the inflammatory process of acute coronary syndromes.
  43. pmc CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes
    Marta Epeldegui
    Department of Microbiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11448. 2010
    ..Since HIV produced in PBMC contains host cell CD40 ligand (CD40L) incorporated into the viral membrane, and CD40L is known to induce AID expression in human B cells, the ..
  44. ncbi alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity
    S L Peng
    Section of Rheumatology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 158:2464-70. 1997
    ..T cells and gamma delta T cells regulate systemic autoimmunity, lupus-prone mice were rendered deficient in CD40 ligand and/or alpha beta T cells by intercrossing CD40L -/- and TCR-alpha -/- knockouts, generating CD40L-intact or -..
  45. pmc CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with histoplasma capsulatum
    P Zhou
    Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 187:1315-24. 1998
    ..Costimulatory molecules such as CD40 ligand (CD40L) have been shown to be a central regulator of type 1 responses in vivo...
  46. ncbi Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells. A redefinition of the TI-2 vs T cell-dependent antigen dichotomy
    C M Snapper
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814
    J Immunol 154:1177-87. 1995
    ..in these responses, for CD40-mediated signaling mediated by binding of the inducible T cell membrane protein, CD40 ligand (CD40L)...
  47. pmc Multiple cytokines sharing the common receptor gamma chain can induce CD154/CD40 ligand expression by human CD4+ T lymphocytes via a cyclosporin A-resistant pathway
    J D Fayen
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Immunology 104:299-306. 2001
    Expression of CD154/CD40 ligand (CD154/CD40L), an important molecular component of CD4+ T-cell help, can be triggered by T-cell receptor (TCR) stimulation...
  48. ncbi Estrogen increases CD40 ligand expression in T cells from women with systemic lupus erythematosus
    V Rider
    School of Biological Sciences, University of Missouri Kansas City, USA
    J Rheumatol 28:2644-9. 2001
    To examine the in vitro effects of estrogen on CD40 ligand (CD40L) expression in peripheral blood T cells isolated from patients with systemic lupus erythematosus (SLE) and normal controls.
  49. ncbi Blockade of CD40-CD40 ligand protects against renal injury in chronic proteinuric renal disease
    Lukas Kairaitis
    Department of Renal Medicine, The University of Sydney at Westmead Hospital, Westmead, Sydney, Australia
    Kidney Int 64:1265-72. 2003
    Interaction between CD40 and CD40 ligand (CD40L) is involved in both cognate and innate immune responses. Blockade of CD40-CD40L interactions reduces severity of renal injury in murine lupus nephritis and membranous nephropathy...
  50. ncbi Characterization of RNA binding proteins associated with CD40 ligand (CD154) mRNA turnover in human T lymphocytes
    W F Rigby
    Department of Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 163:4199-206. 1999
    CD154 (CD40 ligand (CD40L)) has been demonstrated to play an essential role in the development of humoral and cellular immunity through its interaction with CD40...
  51. ncbi Isolation of cDNAs encoding T-BAM, a surface glycoprotein on CD4+ T cells mediating contact-dependent helper function for B cells: identity with the CD40-ligand
    L R Covey
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    Mol Immunol 31:471-84. 1994
    ..Taken together, these data unify the biology and structure of T-BAM and CD40-L and this synthesis has implications for understanding the T cell regulation of the humoral immune response...
  52. ncbi Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer
    A W Tong
    Cancer Immunology Research Laboratory, Baylor Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas 75246, USA
    Clin Cancer Res 7:691-703. 2001
    ..Treatment with the soluble recombinant CD40 ligand (CD40L) molecules gp39 or CD40L-trimer significantly reduced [3H]thymidine uptake in BT-20 and T47D cells by up ..
  53. ncbi Regulation of CD40 ligand expression on naive CD4 T cells: a role for TCR but not co-stimulatory signals
    A I Jaiswal
    Department of Biology, University of California San Diego 92093 0063, USA
    Int Immunol 8:275-85. 1996
    We have investigated the roles of TCR and accessory co-stimulatory signals in the induction of CD40 ligand (CD40L) on CD4 cells...
  54. ncbi Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions
    M N Kweon
    Department of Oral Biology, Immunobiology Vaccine Center, University of Alabama Medical Center, Birmingham 35294, USA
    J Immunol 162:1904-9. 1999
    b>CD40 ligand (CD40L) gene-disrupted (CD40L-/-) mice were employed to examine the role of costimulatory signals via CD40L-CD40 interactions in mucosally induced tolerance...
  55. pmc CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis
    P J Blair
    National Institute of Diabetes and Digestive and Kidney Diseases Navy Transplantation and Autoimmunity Branch, Naval Medical Research Center, Bethesda, Maryland 20889 5607, USA
    J Exp Med 191:651-60. 2000
    Signals generated through CD28-B7 and CD40 ligand (CD40L)-CD40 interactions have been shown to be crucial for the induction of long-term allograft survivability...
  56. ncbi CD40 ligand in pathogenesis of autoimmune ovarian disease of day 3-thymectomized mice: implication for CD40 ligand antibody therapy
    Colin Sharp
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 170:1667-74. 2003
    The blockade of CD40 ligand (CD40L) is effective in autoimmune disease prevention. Recently, a brief period of CD40L mAb treatment was reported to induce tolerance and enhancement of CD4(+)CD25(+) regulatory T cell activity...
  57. ncbi Effect of CD40--CD40 ligand interaction on diacylglycerol-protein kinase C and inositol trisphosphate-Ca(2+) signal transduction pathway in human umbilical vein endothelial cells
    Jin Chuan Yan
    Department of Cardiology, Affiliated Zhong Da Hospital, Southeast University, Nanjing 210009, China
    Clin Chim Acta 337:133-40. 2003
    Increasing evidence shows that CD40-CD40L interaction plays a crucial role in the pathogenesis of atherosclerosis and coronary artery disease. The mechanism of CD40-CD40L interaction might be related to signal transduction via receptor...
  58. ncbi Gene transfer of the CD40-ligand to human dendritic cells induces NK-mediated antitumor effects against human carcinoma cells
    Kei Tomihara
    Department of Molecular Medicine, Sapporo Medical University, Sapporo, Japan
    Int J Cancer 120:1491-8. 2007
    The CD40-ligand (CD40L) is a key molecule for the activation of dendritic cells (DCs), followed by the induction of DC maturation and cytokine production...
  59. ncbi Percutaneous transluminal mitral valvuloplasty reduces circulating soluble CD40 ligand in rheumatic mitral stenosis
    Mien Cheng Chen
    Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, 123Ta Pei Rd, Niao Sung Hsiang, Kaohsiung Hsien 83301, Taiwan, ROC
    Chest 128:36-41. 2005
    Recent data suggest that the pathogenesis of vascular inflammation and thrombosis involves CD40 ligand (CD40L), which is mostly derived from platelets...
  60. ncbi Effect of alternate-day hydrocortisone therapy on the immunologically immature rat. II: Changes in T- and B-cell areas in spleen
    A F el Fouhil
    Department of Pharmacology and Toxicology, New Jersey Medical School, UMDNJ, Newark 07103 2714
    Toxicol Pathol 21:383-90. 1993
    ..Medium-sized B lymphocytes of the spleen, reported to be responsible for IgM synthesis, appeared to be subjected to a different mechanism of hydrocortisone action, other than lysis, resulting ..
  61. pmc Leptospiral proteins recognized during the humoral immune response to leptospirosis in humans
    H Guerreiro
    , Oswaldo Cruz Foundation, Brazilian Ministry of Health, 40295-001, Brazil
    Infect Immun 69:4958-68. 2001
    ..acute and convalescent phases of illness, antibodies to lipopolysaccharide were predominantly immunoglobulin M (IgM) while antibodies to proteins were exclusively IgG...
  62. ncbi Functional maturation of immature B cells accumulated in the periphery by an intraperitoneal administration of a traditional Chinese medicine, xiao-chai-hu-tang (Japanese name: shosaiko-to)
    T Kawakita
    Kampo Research Laboratories, Kanebo Co. Ltd, Osaka, Japan
    Immunopharmacol Immunotoxicol 9:299-317. 1987
    ..Relative decrease of IgM+IgD+ cells at early phase was more profound in peritoneal cells (PC) than in spleen cells...
  63. ncbi Rapid purification and monitoring of immunoglobulin M from ascites by perfusion ion-exchange chromatography
    E McCarthy
    PerSeptive Biosystems, Inc, Framingham, MA 01701, USA
    J Chromatogr A 743:163-70. 1996
    A purification and on-line monitoring procedure for IgM was developed. Perfusion ion-exchange chromatography was used for rapid purification of IgM from ascites fluid and hybridoma supernatant...
  64. ncbi Immunoglobulin M and G antibodies in mice in response to Toxoplasma gondii (S-273) infection and their antigen recognition patterns in western blotting on various post-infection days
    S K Rai
    Department of Pathology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal
    Kansenshogaku Zasshi 68:1318-23. 1994
    ..antigens were studied on various post-infection days (PIDs) (2nd to 36th PIDs) using a commercially available IgM and IgG enzyme linked immunosorbent assay (ELISA) test systems and Western blotting (WB) technique...
  65. ncbi Sample preparation for the analysis of flavors and off-flavors in foods
    J G Wilkes
    Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA
    J Chromatogr A 880:3-33. 2000
    ..Purge-and-trap GC analysis of dairy products, seafoods, and garlic may require heating, microwave-mediated distillation, purging ..
  66. ncbi [Detection of bactericidal antibody in the breast milk of a mother infected with enterohemorrhagic Escherichia coli O157:H7]
    E Adachi
    Department of Infectious Diseases Research, National Children's Medical Research Center
    Kansenshogaku Zasshi 73:451-6. 1999
    ..In the colostrum and mature milk, high levels of IgA and IgM, and no IgG antibodies against EHEC O157 LPS were detected...
  67. ncbi Immunoglobulin M and G antibody response in rabbits after experimental Haemophilus ducreyi infection
    F Muller
    Department of Medical Microbiology, Institute of Hygiene, Hamburg
    Zentralbl Bakteriol Mikrobiol Hyg A 268:238-44. 1988
    ..Basically, the kinetics of IgM and IgG antibody synthesis was the same as in other bacterial infections...
  68. ncbi Cluster headache is not associated with signs of a systemic inflammation
    I N Remahl
    Departments of Neurology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    Headache 40:276-82. 2000
    ..counts, creatinine, albumin, creatine kinase, electrophoreses of serum (with haptoglobin, orosomucoid, IgG, IgM), von Willebrand's factor, antinuclear antibodies, rheumatoid factor, cytoplasmic antineutrophil cytoplasmic ..
  69. ncbi Analysis of codeine, dihydrocodeine and their glucuronides in human urine by electrokinetic capillary immunoassays and capillary electrophoresis-ion trap mass spectrometry
    A B Wey
    Department of Clinical Pharmacology, University of Berne, Switzerland
    J Chromatogr A 895:133-46. 2000
    ..conjugated codeinoids in these urines and their identification was accomplished by capillary electrophoresis-ion trap mass spectrometry (CE-MS)...
  70. pmc Hantavirus infection in children in Argentina
    N C Pini
    Instituto Nacional de Enfermedades Virales Humanas, Pergamino, Argentina
    Emerg Infect Dis 4:85-7. 1998
    Clinical hantavirus infection was diagnosed in five Argentine children ages 5 to 11 years by immunoglobulin M (IgM)- capture enzyme-linked immunosorbent assay using Sin Nombre virus (SNV) antigens...
  71. ncbi Effects of Ajoene on lymphocyte and macrophage membrane-dependent functions
    E L Romano
    , Caracas, Venezuela
    Immunopharmacol Immunotoxicol 19:15-36. 1997
    ..PHA), phorbol myristate acetate (PMA) and anti-CD3, and the capping formation induced in B lymphocytes by anti-IgM antibodies...
  72. ncbi Evaluation of purge-and-trap-high-resolution gas chromatography-mass spectrometry for the determination of 27 volatile organic compounds in marine water at the ng l(-1) concentration level
    T Huybrechts
    Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Belgium
    J Chromatogr A 893:367-82. 2000
    Purge-and-trap combined with high-resolution gas chromatography and detection by mass spectrometry was evaluated for the analysis of 27 volatile organic compounds (VOCs) in marine water samples down to ng l(-1) concentration levels...
  73. ncbi [Responsiveness of a new parvovirus B19 antigen produced in baculovirus expression system to B19-specific IgG and IgM antibodies in every epidemic, 1968, 1980, 1987 and 1992 in Japan]
    T Nunoue
    School of Health Sciences, Kyushu University
    Kansenshogaku Zasshi 69:546-52. 1995
    ..parvovirus infection by other methods as radio immunoassay and/or enzyme-linked immunosolvent assay for B19-IgG and IgM using other antigens and by detection of B19-genome DNA using the polymerase chain reaction...
  74. ncbi Non-phagocytic adherent cells as contaminants in peritoneal macrophage cultures from conventionally housed mice
    B Johne
    Institute of Microbiology, Dental Faculty, University of Oslo, Norway
    Acta Pathol Microbiol Immunol Scand C 95:233-9. 1987
    ..as B-lymphocytes by demonstrating surface immunoglobulin with fluorescence labelled goat-F(ab)2-anti-mouse IgG + IgM antibody, as non-phagocytes by latex beads phagocytosis test, and as non-T cells with an anti-Thy 1 monoclonal ..
  75. ncbi [A case of hemolytic uremic syndrome documented co-infection of vertoxin producing Escherichia coli O157 and other pathogens]
    Y Yagi
    Department of Pediatrics, Ibara Municial Hospital
    Kansenshogaku Zasshi 71:935-8. 1997
    ..coli O125, which is one of the enteropathogenic E. coli, were detected from her stool culture. However, the IgM antibody against verotoxin producing E...
  76. ncbi Acrylamide induced immunosuppression in rats and its modulation by 6-MFA, an interferon inducer
    S I Zaidi
    Preventive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India
    Immunopharmacol Immunotoxicol 16:247-60. 1994
    ..Potentiation of EAC-rosettes, hemagglutination titre, IgM-PFC and DTH response against SRBC was observed. It is concluded that 6-MFA ameliorate the ACR induced toxicity...
  77. ncbi [Two cases of spotted fever group rickettsiosis contracted in southern parts of Africa]
    M Kimura
    Department of Infectious Diseases and Applied Immunology, University of Tokyo
    Kansenshogaku Zasshi 72:1311-6. 1998
    ..conorii) for both IgM and IgG classes...
  78. ncbi [A case of neonatal herpes simplex virus encephalitis with calcifications of thalamus and basal ganglia]
    H Takahashi
    Department of Pediatrics, Juntendo University, Juntendo Urayasu Hospital, Chiba
    No To Hattatsu 22:179-83. 1990
    ..were 1:4 to 1:8 during hospitalization and those in CSF were not increased significantly, ELISA titers for IgG and IgM in serum and CSF rose significantly. The diagnosis of HSV encephalitis was made at 41 days of age...
  79. ncbi Antibody to silicone and native macromolecules in women with silicone breast implants
    A Vojdani
    Immunosciences Laboratory, Inc, Beverly Hills, CA 90211
    Immunopharmacol Immunotoxicol 16:497-523. 1994
    ..At least at the level of two standard deviation silicone specific antibodies, IgG, IgA IgM, IgE and IgG+IgA+IgM antibodies were detected above the mean of normal controls...
  80. ncbi Enhancement of cellular and humoral immunity in young broilers by the dietary supplementation of beta-hydroxy-beta-methylbutyrate
    A L Peterson
    Department of Poultry Science, North Carolina State University, Raleigh 27695-7608, USA
    Immunopharmacol Immunotoxicol 21:307-30. 1999
    ..During the secondary response, birds consuming the 0.10% HMB diet had elevated IgM levels as well as increased total anti-SRBC levels over the controls in Experiments 1 and 3...
  81. ncbi [Circadian rhythm in allergic inflammation]
    C R Baumgarten
    , ,
    Pneumologie 48:91-2. 1994
    ..Total plasma protein IgA, IgM, IgG and IgE show a distinct bioperiodicity with a minimum during the night, cellular elements like T11, T4 and B-..
  82. ncbi Immunological alterations associated with Plasmodium vivax malaria in South Korea
    H K Lee
    Department of Clinical Pathology, College of Medicine, Catholic University of Korea, 62 Youido dong, Youngdeungpo gu, Seoul, 150 713, South Korea
    Ann Trop Med Parasitol 95:31-9. 2001
    ..Although serum concentrations of IgE (and, to a lesser extent, IgM) were elevated in the patients at diagnosis, they were subnormal on day 10 post-treatment and normal at the day-59 ..
  83. ncbi [Study on local immune response in Escherichia coli-induced experimental urinary tract infection in mice--infiltration of Ia-positive cells, macrophages, neutrophils, T cells and B cells]
    T Hirose
    Department of Urology, Sapporo Medical College
    Kansenshogaku Zasshi 66:964-73. 1992
    ..were stained, including Ia-positive cells, macrophages, neutrophils, T cells (CD4+ and CD8+) and B cells (IgA, IgM, IgG-positive B cell)...
  84. ncbi [Localization of immunoglobulins in the central nervous system]
    M Ariizumi
    Department of Pediatrics, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama
    No To Hattatsu 25:107-13. 1993
    ..Developing human brains were obtained from autopsies, and the regional localization of IgG, IgA and IgM was examined as a function of age...
  85. ncbi Production and characterization of monoclonal antibodies specific for pathogenic serogroups O:3, O:8, and O:9 of Yersinia enterocolitica
    M Schmidt
    PROGEN Biotechnical Laboratories, Heidelberg
    Zentralbl Bakteriol Mikrobiol Hyg A 265:113-23. 1987
    ..Finally, 2 MAbs 4C2 (IgM) and 6G5 (IgM), showed reactivity both in IFA and agglutination assays with "esculin negative" biogroups 1 (..
  86. ncbi Adriamycin custom-tailored immunoconjugates in the treatment of human malignancies
    R K Oldham
    Williamson Medical Center, Biological Therapy Institute, Franklin, TN 37065-1676
    Mol Biother 1:103-13. 1988
    ..Preliminary serologic evidence suggests that the development of an IgM antibody, which is specific against the mouse monoclonal antibody, has the specificity and sensitivity to predict ..
  87. ncbi [Fluctuations in serum antigens and antibodies in a patient with primary cutaneous aspergillosis associated with acute leukemia]
    S Fujita
    Department of Clinical Laboratory of Medicine, School of Medicine, Kanazawa University
    Kansenshogaku Zasshi 69:218-22. 1995
    ..Ig) A class antibody determined by ELISA, while sera obtained on day 24 showed seroconversion of IgG and IgM class antibodies...
  88. ncbi Occurrence and determination of organic pollutants in tap and surface waters of the Gdańsk district
    M Biziuk
    Faculty of Chemistry, Technical University of Gdansk, Poland
    J Chromatogr A 733:171-83. 1996
    ..chromatography-electron capture detection (GC-ECD) for determination of volatile organohalogen compounds: purge and trap with a gas chromatography-flame ionization detection for determination of volatile hydrocarbons; sorption on solid ..
  89. ncbi Serum opsonins to group B meningococci
    H Sjursen
    Medical Department, University of Bergen, Haukeland Hospital, Norway
    Acta Pathol Microbiol Immunol Scand C 95:283-9. 1987
    ..Two weeks later all had a marked increase in IgG, IgM and IgA serum antibodies. Vaccination caused a marked increase in serum IgG antibodies...
  90. ncbi Modulator effect of Toxoplasma lysate antigen in mice experimentally infected with Plasmodium berghei
    N Suzuki
    Department of Veterinary Physiology, Obihiro University, Hokkaido, Japan
    Zentralbl Bakteriol Mikrobiol Hyg A 264:422-34. 1987
    ..By the indirect fluorescent antibody technique, anti-Plasmodium IgM and IgG titers were detected in sera from mice treated with TLA or TLA-Obioactin before infection.
  91. ncbi [A case of diffuse panbronchiolitis with SLE complicated by fungal infection]
    Y Wada
    Department of Pediatrics, Kashiwa Hospital, Tokyo Jikei University School of Medicines
    Kansenshogaku Zasshi 75:970-6. 2001
    ..Regarding serum virus antibody values at the time of SLE diagnosis, IgG and IgM of human Parvovirus B19 (B19) were positive by the EIA test and also by the serum PCR test...
  92. ncbi [Murine typhus infected in Oku-etsu area, Fukui Prefecture]
    K Takagi
    First Department of Internal Medicine, Fukui Medical University, Shimoaizuki 23-3, Matsuoka, Fukui 910-1193, Japan
    Kansenshogaku Zasshi 75:341-4. 2001
    ..Titers of anti-Rickettsia typhi serum antibodies (IgM, -G) were elevated (1:80, 1:640) and she was diagnosed as having murine typhus...
  93. ncbi A dengue outbreak among camp participants in a Caribbean island, 1995
    R Lyerla
    National Center for Infectious Diseases, CDC, Public Health Service, US Department of Healthand Humam Services, Atlanta, GA, USA
    J Travel Med 7:59-63. 2000
    ..tested for virus isolation, polymerase chain reaction (PCR), plaque-reduction neutralization (PRNT) or anti-dengue IgM and IgG antibody...
  94. ncbi [Serological cross-reaction among Bartonella henselae, Chlamydia pneumoniae and Coxiella burnetii by indirect fluorescence antibody method]
    H Tsuneoka
    Department of Clinical Laboratory, Yamaguchi-ken Kouseiren Nagato General Hospital
    Kansenshogaku Zasshi 75:406-10. 2001
    ..pneumoniae infection, and was positive in 3 (titers being 1:64) of 12 patients with Q fever, whereas B. henselae IgM antibody was negative in all the patients with C. pneumoniae infection or Q fever. C...
  95. ncbi Beneficial effect of indapamide in experimental myocardial ischemia
    F R Boucher
    Laboratoire de Physiologie Cellulaire Cardiaque, , Grenoble, France
    Am J Hypertens 5:22-5. 1992
    ..ESR) analysis of coronary effluents, collected during the first minutes of reperfusion in the presence of the spin-trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO), revealed a significant modification in the treated group...
  96. ncbi Platelet antibodies in patients with migraine
    M Schabet
    , , Germany
    Headache 38:472-4. 1998
    ..5% of patients with migraine without aura, 7.6% of patients with migraine with aura, and in 7.5% of controls; IgM antibodies were found in 11.9% of patients with migraine without aura, in 30...
  97. ncbi A study of bronchus-associated lymphoid tissue in a rat model of chronic pulmonary infection with Pseudomonas aeruginosa
    H Kitazawa
    Department of Internal Medicine, Hamamatsu University School of Medicine
    Kansenshogaku Zasshi 71:214-21. 1997
    ..Immunohistochemical examination demonstrated that Ia+ cells, helper T cells, surface IgM-positive (sIgM+) cells and sIgA+ cells had gradually increased in BALT and the walls of peripheral airways during ..
  98. ncbi [Studies on immune response in mouse model of experimental Chlamydia trachomatis intrauterine infections]
    T Satoh
    Department of Urology, School of Medicine, Sapporo Medical University
    Kansenshogaku Zasshi 68:304-13. 1994
    ..among the B cell lineage, there was moderate infiltration by IgA-positive B cells, whereas the infiltration by IgM-positive B cells and IgG-positive B cells was very slight. 2. C...
  99. pmc Rapid and simple hepatitis assays: encouraging results from a blood donor population in Zimbabwe
    D Mvere
    National Blood Transfusion Service, Harare, Zimbabwe
    Bull World Health Organ 74:19-24. 1996
    ..An HCV IgM test (Abbott) was used for samples that produced discordant results, and all HCV-reactive samples were confirmed ..
  100. ncbi [Monoclonal antibodies to herpes simplex viruses antigens--specificity and utility in rapid serotyping of clinical isolates]
    T Kojima
    Eiken Chemical Co, Ltd
    Kansenshogaku Zasshi 65:293-8. 1991
    ..The remaining three antibodies, two of which were found to be immunoglobulin type IgM, reacted with neither HSV-1 nor HSV-2 antigens in WB assay...
  101. ncbi Intersegmental interneurons serving larval and pupal mechanosensory reflexes in the moth Manduca sexta
    B Waldrop
    Arizona Research Laboratories, University of Arizona, Tucson 85721
    J Comp Physiol A 171:195-205. 1992
    1. Intersegmental interneurons (INs) that participate in the larval bending reflex and the pupal gin trap closure reflex were identified in the isolated ventral nerve cord of Manduca sexta...

Research Grants67

  1. Preclinical development of recombinant antigen diagnostics for Lassa fever
    Robert F Garry; Fiscal Year: 2013
    ..In MILESTONE 1 we will development commercial Lassa fever recombinant antigen-capture and immunoglobulin M (IgM) and immunoglobulin G (IgG) antibody-capture ELISA using a Performance Panel of well-characterized sera...
  2. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..In the proposed studies, we will examine and compare SIV-specific IgA, IgG and IgM immune responses and antibody binding properties in peripheral blood, and mucosal secretions of macaques inoculated ..
  3. Immune Tolerance in Non-clonal Immune Systems
    David Nemazee; Fiscal Year: 2013
    ..Macroself Ag transgenics with specificity for IgM, Ig-kappa, IgD, and IgG2a allowed analysis of immune tolerance in different cell compartments and developmental ..
  4. Arturo Casadevall; Fiscal Year: 2014
    ..Abs with identical V regions;3) To establish whether constant region-mediated changes in specificity extend to IgM, IgE and IgA isotypes;and 4) Construction of a second-generation mouse-human chimeric Ab suitable for human trials...
  5. Absorption of maternal antibodies from the gastrointestinal tract
    Lynn Puddington; Fiscal Year: 2012
    ..radiolabeled antibodies purified from serum of myeloma patients to show intestinal uptake of IgG, but not IgA, IgE, IgM or IgD (10)...
  6. High throughput screening of bacterial collections for surface proteins of commer
    Roy H Hammerstedt; Fiscal Year: 2010
    ..this hypothesis using a subset of the PEARL collection, as bar coded bacteria, and immunoglobins [IgG1, IgG3, IgM, IgA] selected because of their medical and commercial significance as the target ligands...
  7. Diffusion of viruses across human airway mucus and trapping by antibodies
    SAMUEL LAI; Fiscal Year: 2012
    ..Thus, one approach to block pulmonary infections is to adhesively trap viruses in mucus...
  8. Otoniel Martinez-Maza; Fiscal Year: 2016
    ..We also found that HIV virions carrying CD40 ligand (CD40L), a T cell-produced B cell stimulatory molecule, can drive B cell activation and AICDA expression...
  9. Positive and Negative Regulatory Pathways In Human Lymphoma
    Richard Ford; Fiscal Year: 2007
    ..We will also study the signaling pathways controlling gene expression of the CD40 ligand, CD154, that we believe is intimately involved with driving the signalosome pathway, to ascertain the mechanism ..
  10. ANTIBODY V GENE EXPRESSION B CELL LYMPHOCYTIC LEUKEMIA
    Thomas J Kipps; Fiscal Year: 2013
    ..I and early phase II clinical trials using recombinant adenovirus vectors encoding a recombinant CD40-ligand (Ad- CD154) are direct manifestations of work performed on this proposal...
  11. Phase I, Open-Label Dose-Escalation
    Januario E Castro; Fiscal Year: 2010
    ..activity of a new modality of immuno-gene therapy mediated by transduction of leukemia cells with CD154 (CD40 Ligand) using direct intra-lymph node (intranodal) injection of a replication-defective adenovirus vector that encodes ..
  12. Th17 cell regulation of intestinal IgA production
    Yingzi Cong; Fiscal Year: 2010
    ..hypothesize that 1) Th17 cells promote intestinal IgA production via mechanisms involving IL-17, IL-21, as well as CD40L-CD40 interactions;2) Th17-IgA pathway mediates mucosal IgA response to cholera toxin, which depends on cholera ..
  13. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..additional source of OPG in vivo, and that B cell OPG production is regulated by costimulatory signals such as CD40 Ligand (CD40L) derived from T cells...
  14. Carol E Schrader; Fiscal Year: 2014
    Antibody (immunoglobulin, Ig) class switch causes B lymphocytes to switch from producing IgM to producing IgG, IgA or IgE, which improves the ability of the antibody to remove pathogens and bacterial toxins from the body...
  15. Uttiya Basu; Fiscal Year: 2016
    ..Human patients with inactivating mutations in the AID gene suffer from Hyper-IgM syndrome (HIGM2), whereas aberrant expression of AID may lead to various B and T cell malignancies...
  16. Id3/B Lymphocytes and Atherosclerosis
    Coleen A McNamara; Fiscal Year: 2010
    ..b>IgM and IgG antibodies have been detected in atherosclerotic plaques and titers of antibodies against various oxidized ..
  17. Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B cells
    BRIAN L DIZON; Fiscal Year: 2010
    ..The absolute numbers, phenotype, and tissue distribution of GlcNAc-specific B cells, as well as GlcNAc-specific IgM titers, will be measured by flow cytometry, ELISA, ELISPOT, and immunofluorescence microscopy utilizing clonal ..
  18. Mucosal Immune Ontogeny and Intestinal Microbiota in Infants
    Edward N Janoff; Fiscal Year: 2010
    ..Among plasma cells, the switch from a predominance of those producing IgM to IgA will accompany the acquisition of activated T cells, and 2) The evolution of T and B cell memory cells and ..
  19. Molecular Pathogenesis of Monoclonal B Cell Lymphocytosis and CLL
    Mark C Lanasa; Fiscal Year: 2013
    ..we have found that MBL commonly have mutated immunoglobulin heavy chains (IgVH), express lower levels of surface IgM than CLL, and show enhanced B cell receptor (BCR) signaling when compared to memory B cells...
  20. Paolo Casali; Fiscal Year: 2016
    ..We also contend that estrogen greatly enhances CD154:CD40-induced HoxC4 expression by triggering the binding of estrogen receptors (ERs) to two conserved estrogen ..
  21. Vince N Montes; Fiscal Year: 2014
    ..The CD40-CD40L pathway can be inhibited by a neutralizing antibody to CD40 ligand (CD40L)...
  22. Targeted Dendritic Cell Activation through Multi-Adjuvant Liposomes
    Gretchen Jimenez; Fiscal Year: 2013
    ..is a dual adjuvant system where VesiVax(R) lipid vesicles are formulated with a TLR9 agonist (CpG) and CD40 Ligand fused to the Company's proprietary Hydrophobic Domain (HD) technology...
  23. Glycoproteins and Glycan-Binding IgGs: Biomarkers for Cancer and Inflammatory Di
    Hyesook Kim; Fiscal Year: 2013
    ..and fractionation technologies dependent on glycan structures and glycan-binding specificity of the IgG or IgM (2 major Igs involved with cancer) show promise of obtaining molecular signatures to distinguish prostate cancer ..
  24. Mechanisms of CD40/CD40L in vascular injury and repair
    Guohong Li; Fiscal Year: 2013
    ..Abundant evidence indicates that the CD40-CD40 ligand (CD40L) pathway plays a pivotal role in immune and inflammatory responses...
  25. LORI RUTH COVEY; Fiscal Year: 2014
    ..Historically, there has been a widespread appreciation of the functional significance of interactions between CD40 ligand (CD40L, CD154) on activated CD4+ T cells and CD40 expressed on antigen presenting cells (APC) in both humoral ..
  26. RICHARD SYD KORNBLUTH; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): CD40 ligand (CD40L or CD154) is widely recognized as one of the most important endogenous activators of the immune system...
  27. IgM Antileucocyte Autoantibodies Inhibit Kidney Allograft Rejections
    PETER LOBO; Fiscal Year: 2010
    This research project involves studying naturally occurring IgM autoantibodies that bind to leucocytes (IgM-ALA)...
  28. QIZHI C YAO; Fiscal Year: 2015
    ..We have developed and characterized chimeric CD40 ligand/simian-human immunodeficiency (CD40L/SHIV) virus-like particles (VLPs) which possess the antigen presenting ..
  29. HUMAN B CELL DIFFERENTIATION IN A MODEL SYSTEM
    LORI COVEY; Fiscal Year: 2009
    ..A critical molecule in this regard is the CD40 ligand (CD40L, CD154), which is expressed on activated T cells and through its interaction with CD40 on B cells, ..
  30. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2005
    ..Blockade of CD154 is effective in ameliorating the manifestations of several autoimmune diseases and thus has become an attractive ..
  31. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2003
    ..T and B cells is dependent upon the interaction of the TCR/MHC as well as co-stimulatory molecules, including CD40-CD40L. CD40 and its ligand have been shown to play a critical role in the regulation of both humoral and cell-mediated ..
  32. Eptifibatide as Treatment for Acute Pain Episodes in Sickle Cell Disease
    Kenneth Ataga; Fiscal Year: 2009
    ..The potent inflammatory mediator, CD40 ligand (CD40L), is known to increase leukocyte proliferation, endothelial adhesiveness and procoagulant activity, once ..
  33. Immunotherapy of CLL with lentiviral expressed CD40-ligand
    Boro Dropulic; Fiscal Year: 2006
    ..of the lentiviral vector (LV) to provide efficient and clinically feasible delivery system for CD40-ligand (CD154), a very well known stimulator of T cells in chronic lymphocytic leukemia (CLL)...
  34. ANTIRAT CD40L EFFECTS ON ISLET ALLOGRAFT SURVIVAL
    Karen Kover; Fiscal Year: 1999
    ..The objective of this proposal is to determine the effects of blocking the co-stimulatory molecule, CD40 ligand (using a novel antibody from Biogen, Inc...
  35. AKNA, germinal center reaction and immunity.
    Hector Martinez Valdez; Fiscal Year: 2007
    ..requires cognate receptor/ligand interactions, among which, the ligation of B cetl- CD40 by the T celI-CD40 ligand (CD154) provides the essential stimuli for cell proliferation, survival, and induction of B cell memory...
  36. CD40 Ligand Dysregulation and HIV Pathogenesis
    Claire Chougnet; Fiscal Year: 2009
    ..Interactions between CD40 (on APC) and CD40Ligand [CD40L] (on activated CD4+ T cells) are crucial for such CD4 help...
  37. Regulation of Th1 responses by IL-2 receptor blockade
    John McDyer; Fiscal Year: 2007
    ..We hypothesize CD40 ligand (CD40L)/CD40 interactions play a major role in HAT-mediated inhibition of IL-12- dependent Thl responses and ..
  38. CONTROL OF SWITCH RECOMBINATION BY CD40 LIGAND
    MICHAEL BERTON; Fiscal Year: 2000
    ..T-cell contact-dependent signals required for isotype switching are provided by the CD40 ligand (CD40L)-CD40 interaction, but nothing is known about how these signals regulate isotype switching...
  39. MODEL FOR GENE THERAPY OF X LINKED HYPER IGM
    Ramsay Fuleihan; Fiscal Year: 2001
    ..X- linked hyper IgM, HIGMS-1) is a primary immune deficiency disease that results from defects in the genenfor CD40 ligand (CD40L)...
  40. MOLECULAR MECHANISMS REGULATING CD40L GENE EXPRESSION
    Francis Lobo; Fiscal Year: 2000
    b>CD40 ligand (CD40L) is a T cell surface molecule that is expressed early and transiently after cell activation...
  41. Role of the CD40/CD40L dyad in atherosclerosis
    Masanori Aikawa; Fiscal Year: 2006
    ..Previous work by the applicants established a prominent role of the CD40/CD40 ligand (CD40L) dyad in atherogenesis in vitro and in vivo, and furthermore identified the interruption of CD40/CD40L ..
  42. IgM Fc receptor in CLL
    Hiromi Kubagawa; Fiscal Year: 2013
    ..of this application are to determine the clinical relevance of the enhanced expression of the Fc receptor for IgM (Fc[unreadable]R) by CLL B cells and to explore the role of Fc[unreadable]R signaling in promoting CLL-cell ..
  43. ACTIVATION INDUCED DEAMINASE (AID) INTERACTING PROTEINS
    Michel C Nussenzweig; Fiscal Year: 2011
    ..proteins, that could function in the assumed recruitment of AID to specific RNAs, we have employed MALDI-ion trap MS/MS analysis to identify proteins that are co-purified with flag/HA-tagged AID...
  44. B1 B cells in abdominal obesity and diet-accelerated atherosclerosis in SLE
    Xuemei Zhong; Fiscal Year: 2013
    ..B1 B cells are the source of natural IgM antibodies that protect from atherosclerosis through masking oxidized LDL, inhibiting uptake by macrophage and ..
  45. Regulation of cyclin D3 in B lymphocyte development
    Marcus R Clark; Fiscal Year: 2013
    ..Early in B lymphopoiesis, Igm assembles with surrogate light chain and Iga/Igb to form a pre-BCR that first expands pre-B cell populations ..
  46. TIMOTHY L MANSER; Fiscal Year: 2014
    ..these HISmice with the spirochete bacteria Borrelia hermsii results in a course of infection and resolution via an IgM response that is qualitatively similar, but is not as robust as those observed in infected humans and mouse models...
  47. Homeostasis of the ER in Differentiating B-cells
    Robert A Barrington; Fiscal Year: 2013
    ..This correlates with accelerated induction of XBP1(S) and IgM secretion, but little production of other antibody isotypes...
  48. B cells in CNS autoimmunity
    Scott S Zamvil; Fiscal Year: 2013
    ..BCR only, and one containing B cells that express membrane MOG-specific BCR and can secrete MOG-specific IgM. We will compare EAE susceptibility in these mice to B cell-deficient and MOG-specific BCR knock-in mice that can ..
  49. Defining the interaction of FCRLA with immunoglobulin
    PETER DANIEL BURROWS; Fiscal Year: 2013
    ..Unique among Fc receptors, FCRLA can associate with multiple isotypes of Ig, IgM, IgG and IgA...
  50. J Oriol Sunyer; Fiscal Year: 2016
    ..by applicant): Rainbow trout (our fish model), is known to contain at least three immunoglobulin isotypes, IgM, IgD and the recently discovered IgT...
  51. Biochemical Basis of Somatic Hypermutation
    MYRON GOODMAN; Fiscal Year: 2013
    ..Specific Aim 2 examines the deamination properties of WT AID compared to AID mutants associated with hyper-IgM-2 syndrome in humans, in which Ab diversification fails to occur...
  52. MARK DOUGLAS OKUSA; Fiscal Year: 2014
    ..by applicant): The overall goal of this multi-PI proposal is to investigate the role of naturally occurring IgM anti-leucocyte autoantibodies in inhibiting inflammatory processes that occur after ischemia-reperfusion injury (..
  53. Lynn B Dustin; Fiscal Year: 2015
    ..found that patients with MC have clonal or oligoclonal expansions of B cells expressing rheumatoid factor (RF)-like IgM, frequently encoded by VH1-69, JH4, and V:3-20 Ig gene segments...
  54. Katherine L Knight; Fiscal Year: 2015
    ..GALT explants and TLR and NLR agonists and antagonists to determine the contribution of TLR and NLR ligands and IgM-binding bacterial superantigen-like molecules to B cell proliferation and Ig gene diversification;we will also use ..
  55. Leptin and B cell Function
    Giovanni Franchin; Fiscal Year: 2012
    ..analysis following immunization with NP-Ficoll (T-independent response) revealed increased numbers of NP-specific IgM, but not IgG B cells in ob/ob and db/db mice, in contrast with significantly lower levels of serum IgM or IgG anti-..
  56. Martin F Flajnik; Fiscal Year: 2016
    ..This IgM is expressed in plasma cells as a first wave during development, followed by at least two other waves of plasma ..
  57. Amy L Kenter; Fiscal Year: 2014
    ..development in the bone marrow is characterized by DNA rearrangements termed VDJ joining, leading to expression of IgM antibodies...
  58. Defining genetic pathways to severe systemic autoimmunity
    Edward K Wakeland; Fiscal Year: 2010
    ..with Sle1;and 2) B cell functional polymorphisms leading to B cell expansions in vivo and increased production of IgM autoantibodies recognizing a variety of autoantigens...
  59. Kaihong Su; Fiscal Year: 2015
    ..antibody recognizes a novel pattern recognition receptor NLRC5/NOD27 and induces neutrophil extracellular trap (NET) formation. Furthermore, administration of S4Ab2 or S4Ab4 antibodies in NZB/W F1 mice induces kidney damage...
  60. Chaitan Khosla; Fiscal Year: 2016
    ..A) Mapping TG2-Trx interactions by alanine-scanning mutagenesis;(B) Engineering a Trx mutant to covalently trap and structurally characterize the transient TG2- Trx complex;and (C) Engineering small molecule inhibitors to ..
  61. Lee Ann Garrett-Sinha; Fiscal Year: 2014
    ..undergo enhanced differentiation into ASCs many of which secrete autoantibodies as demonstrated by high titers of IgM and IgG autoantibodies in the serum...
  62. Studies of the role of microRNA miR-16-1 in the NZB mouse model of CLL
    Elizabeth S Raveche; Fiscal Year: 2012
    ..These mice also characteristically make an IgM anti- erythrocyte autoantibody response and polyclonal autoantibodies...
  63. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  64. CD40 LIGAND IN SYSTEMIC LUPUS ERYTHEMATOSUS
    MARY CROW; Fiscal Year: 2002
    ..b>CD40 ligand (C40L), a member of the TNF gene family, mediates the Th cell signals that drive B cell activation and ..
  65. BLyS, APRIL and antibody production in HIV infection
    Andrea Cerutti; Fiscal Year: 2004
    ..switching from IgM to IgG and IgA, is thought to be highly dependent upon engagement of CD40 on B cells by CD40 ligand (CD40L) on antigen-activated CD4+ T cells...
  66. IMMUNE MECHANISMS OF ANTICD40L TRIAL IN SLE
    SYAMAL DATTA; Fiscal Year: 2001
    ..objective is to study the basic immunologic mechanisms underlying the therapeutic effects of a humanized anti-CD40 ligand antibody (anti-CD40L, BG9588) administered into patients with active lupus nephritis...
  67. Using Genechips to Study the Immunological Roles of CD40
    Genhong Cheng; Fiscal Year: 2005
    ..CD40 is activated as a trimer after interaction with its partner, the CD40 ligand (CD40L), which is expressed on the surface of activated CD4+ helper T-cells...