CD40

Summary

Gene Symbol: CD40
Description: CD40 molecule
Alias: Bp50, CDW40, TNFRSF5, p50, tumor necrosis factor receptor superfamily member 5, B cell surface antigen CD40, B cell-associated molecule, CD40 molecule, TNF receptor superfamily member 5, CD40L receptor
Species: human

Top Publications

  1. doi Involvement of nuclear factor κB in platelet CD40 signaling
    Ahmed Hachem
    Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec, Canada H1T 1C8
    Biochem Biophys Res Commun 425:58-63. 2012
  2. pmc The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas
    Pauline G Knox
    Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece
    J Cell Biol 192:391-9. 2011
  3. ncbi CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization
    S S Pullen
    Department of Biology, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877 0368, USA
    Biochemistry 37:11836-45. 1998
  4. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
  5. ncbi A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease
    Yaron Tomer
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Thyroid 12:1129-35. 2002
  6. ncbi CD40 ligand gene and Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1 7 22 Suehiro, Tsurumi, Yokohama, Japan
    Eur J Hum Genet 12:1062-8. 2004
  7. pmc Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations
    Hye Soon Lee
    Hanyang University College of Medicine and the Hospital for Rheumatic Diseases, Seoul, South Korea
    Arthritis Rheum 60:364-71. 2009
  8. doi Association analysis of CD40 gene polymorphism with acute coronary syndrome
    Jinchuan Yan
    Department of Medicine, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, 212001, Zhenjiang, Jiangsu Province, People s Republic of China
    Clin Exp Med 10:253-8. 2010
  9. doi The relationship between CD40 gene polymorphism and unstable coronary atherosclerotic plaques
    Cuiping Wang
    Division of Cardiology, Department of Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
    Clin Cardiol 33:E55-60. 2010
  10. doi A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis
    Vassilios M Vazgiourakis
    Laboratory of Molecular Medicine and Human Genetics, Department of Medicine, University of Crete, Heraklion, Greece
    Ann Rheum Dis 70:2184-90. 2011

Research Grants

  1. PROLIFERATIVE CONDITIONING OF TUMOR-COMPETENT DENDRITIC CELL PRECURSORS
    Peter A Cohen; Fiscal Year: 2010
  2. Targeted Dendritic Cell Activation through Multi-Adjuvant Liposomes
    Gretchen Jimenez; Fiscal Year: 2013
  3. Combination gene therapy for metastatic colon cancer
    Shu Hsia Chen; Fiscal Year: 2010
  4. RICHARD SYD KORNBLUTH; Fiscal Year: 2014
  5. Targeted Gene Therapy for Lymphoma
    Bruce F Smith; Fiscal Year: 2010
  6. QIZHI C YAO; Fiscal Year: 2015
  7. Otoniel Martinez-Maza; Fiscal Year: 2016
  8. Positive and Negative Regulatory Pathways In Human Lymphoma
    Richard Ford; Fiscal Year: 2007
  9. Yuri Persidsky; Fiscal Year: 2016
  10. MERVYN N WEITZMANN; Fiscal Year: 2016

Detail Information

Publications235 found, 100 shown here

  1. doi Involvement of nuclear factor κB in platelet CD40 signaling
    Ahmed Hachem
    Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, 5000 Belanger, Montreal, Quebec, Canada H1T 1C8
    Biochem Biophys Res Commun 425:58-63. 2012
    b>CD40 ligand (CD40L) is a thrombo-inflammatory molecule that predicts cardiovascular events...
  2. pmc The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas
    Pauline G Knox
    Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece
    J Cell Biol 192:391-9. 2011
    b>CD40, a tumor necrosis factor (TNF) receptor family member, is widely recognized for its prominent role in the antitumor immune response...
  3. ncbi CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization
    S S Pullen
    Department of Biology, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut 06877 0368, USA
    Biochemistry 37:11836-45. 1998
    b>CD40 is a TNF receptor superfamily member that provides activation signals in antigen-presenting cells such as B cells, macrophages, and dendritic cells...
  4. ncbi CD40-CD40 ligand
    C van Kooten
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 67:2-17. 2000
    b>CD40 is a cell surface receptor that belongs to the tumor necrosis factor-R (TNF-R) family, and that was first identified and functionally characterized on B lymphocytes...
  5. ncbi A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease
    Yaron Tomer
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Thyroid 12:1129-35. 2002
    ..Among the genes mapped to 20q11 was the CD40 gene, an important costimulatory molecule and a good positional candidate gene for GD...
  6. ncbi CD40 ligand gene and Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Gastrointestinal Diseases, SNP Research Center, RIKEN, 1 7 22 Suehiro, Tsurumi, Yokohama, Japan
    Eur J Hum Genet 12:1062-8. 2004
    ..One of the identified peaks was located on the Xq26 region. A recent report of elevated expression of CD40 ligand (CD40L), which maps to Xq26, during the acute-phase KD, and its relationship to the development of coronary ..
  7. pmc Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations
    Hye Soon Lee
    Hanyang University College of Medicine and the Hospital for Rheumatic Diseases, Seoul, South Korea
    Arthritis Rheum 60:364-71. 2009
    ..The aim of this study was to determine whether the genetic variants at 4q27, 6q23, CCL21, TRAF1/C5, and CD40 identified in Caucasians are also associated with RA in a Korean case-control collection...
  8. doi Association analysis of CD40 gene polymorphism with acute coronary syndrome
    Jinchuan Yan
    Department of Medicine, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, 212001, Zhenjiang, Jiangsu Province, People s Republic of China
    Clin Exp Med 10:253-8. 2010
    Current evidence shows that the CD40-CD40 ligand (CD40-CD40L) system plays a crucial role in the development, progression and outcome of acute coronary syndrome (ACS)...
  9. doi The relationship between CD40 gene polymorphism and unstable coronary atherosclerotic plaques
    Cuiping Wang
    Division of Cardiology, Department of Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China
    Clin Cardiol 33:E55-60. 2010
    Recently, CD40 polymorphism was found to be associated with acute coronary syndromes. However, few study was involved in the relationship between CD40 polymorphism and the risk of the vulnerable plaque to rupture so far.
  10. doi A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis
    Vassilios M Vazgiourakis
    Laboratory of Molecular Medicine and Human Genetics, Department of Medicine, University of Crete, Heraklion, Greece
    Ann Rheum Dis 70:2184-90. 2011
    ..SLE) sustained CD40L expression by T cells and platelets activates a variety of cells via its receptor CD40 contributing to disease pathogenesis...
  11. doi Influence of MIF, CD40, and CD226 polymorphisms on risk of rheumatoid arthritis
    Ruiping Liu
    Department of Orthopedics, the Affiliated Hospital of Nanjing Medical University, Changzhou Second People s Hospital, Changzhou, China
    Mol Biol Rep 39:6915-22. 2012
    ..The CD40 is also crucial for some relevant functions of the immune system and may be related to rheumatoid arthritis (RA)...
  12. pmc Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50
    E A Clark
    Proc Natl Acad Sci U S A 83:4494-8. 1986
    Two human B-cell differentiation antigens, Bp35 and Bp50, apparently play distinct roles as signal receptors in B-cell activation...
  13. ncbi The CD40 antigen and its ligand
    J Banchereau
    Schering Plough, Laboratory for Immunological Research, Dardilly, France
    Annu Rev Immunol 12:881-922. 1994
    b>CD40 is an integral membrane protein found on the surface of B lymphocytes, dendritic cells, follicular dendritic cells, hematopoietic progenitor cells, epithelial cells, and carcinomas...
  14. ncbi A novel RING finger protein interacts with the cytoplasmic domain of CD40
    H M Hu
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 269:30069-72. 1994
    b>CD40 is a member of the tumor necrosis factor receptor family and, like other members, it appears to possess no intrinsic signaling capacity (e.g...
  15. ncbi Involvement of CRAF1, a relative of TRAF, in CD40 signaling
    G Cheng
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Science 267:1494-8. 1995
    b>CD40 is a receptor on the surface of B lymphocytes, the activation of which leads to B cell survival, growth, and differentiation...
  16. ncbi TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
    M Rothe
    Molecular Biology Department, Tularik, Inc, South San Francisco, CA 94080, USA
    Science 269:1424-7. 1995
    ..The role of TRAFs in the TNF-R2 and CD40 signal transduction pathways, which result in the activation of transcription factor NF-kappa B, was investigated...
  17. ncbi The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
    G Mosialos
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
    Cell 80:389-99. 1995
    ..LAP1 binds to the p80 TNFR, CD40, and the lymphotoxin-beta receptor, while EBI6 associates with the p80 TNFR...
  18. pmc TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling
    T K Ishida
    Department of Oncology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 93:9437-42. 1996
    Signals emanating from CD40 play crucial roles in B-cell function. To identify molecules that transduce CD40 signalings, we have used the yeast two-hybrid system to done cDNAs encoding proteins that bind the cytoplasmic tail of CD40...
  19. pmc Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway
    M Kashiwada
    Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan
    J Exp Med 187:237-44. 1998
    b>CD40 activates nuclear factor kappa B (NF kappa B) and the mitogen-activated protein kinase (MAPK) subfamily, including extracellular signal-regulated kinase (ERK)...
  20. ncbi CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    V Henn
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Nature 391:591-4. 1998
    b>CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the cytokine TNF-alpha, was originally identified on stimulated CD4+ T cells, and later on stimulated mast cells and basophils...
  21. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
    ..Here we show that signalling through CD40 on the antigen-presenting cells can replace the requirement for TH cells, indicating that T-cell 'help', at least ..
  22. pmc Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40
    N Tsukamoto
    Department of Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 96:1234-9. 1999
    b>CD40 signaling modulates the immune response at least in part by activation of nuclear factor kappaB (NFkappaB)...
  23. ncbi The selective triggering of CD40 on keratinocytes in vivo enhances cell-mediated immunity
    Bruce W Fuller
    Dartmouth Medical School, Department of Microbiology, Lebanon, NH 03756, USA
    Eur J Immunol 32:895-902. 2002
    b>CD40 is expressed on a wide array of hematopoietic and non-hematopoietic cells, including keratinocytes...
  24. ncbi CD40 ligation-induced cytokine production in human skin explants is partly mediated via IL-1
    Arjen R Companjen
    Department of Immunology, Erasmus University and University Hospital Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Int Immunol 14:669-76. 2002
    b>CD40 ligation by CD40 ligand(+) CD4(+) T cells has been claimed to be involved in inflammatory responses in human skin...
  25. ncbi CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis
    Maria Chiara Deregibus
    Cattedra di Nefrologia, Dipartimento di Medicina Interna, Universita di Torino, and Centro Ricerca Medicina Sperimentale CeRMS, Torino 10126, Italy
    J Biol Chem 278:18008-14. 2003
    b>CD40 has been involved in tumor and inflammatory neoangiogenesis...
  26. pmc Differential induction of nuclear factor-kappaB and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferation
    Jalal Ahmed-Choudhury
    Liver Research Laboratories, Medical Research Council Centre for Immune Regulation, University of Birmingham Institute of Clinical Science, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, United Kingdom
    Mol Biol Cell 14:1334-45. 2003
    b>CD40, a tumor necrosis factor receptor superfamily member, is up-regulated on intraheptatic endothelial cells (IHEC) and epithelial cells during inflammatory liver disease, and there is evidence that the functional outcome of CD40 ..
  27. pmc Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions
    Amrie C Grammer
    Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 112:1506-20. 2003
    To determine the role of CD154-CD40 interactions in the B cell overactivity exhibited by patients with active systemic lupus erythematosus (SLE), CD19+ peripheral B cells were examined before and after treatment with humanized anti-CD154 ..
  28. ncbi HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, PA 19104, USA
    Int Immunol 17:103-16. 2005
    ..delivered protein, Vpr down-modulated the expression of several immunologically important molecules including CD40, CD80, CD83 and CD86 costimulatory molecules on MDM (monocyte-derived macrophage) and MDDC (monocyte-derived ..
  29. pmc TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells
    Clare C Davies
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, United Kingdom
    Mol Cell Biol 25:9806-19. 2005
    The emerging role of CD40, a tumor necrosis factor (TNF) receptor family member, in immune regulation, disease pathogenesis, and cancer therapy necessitates the analysis of CD40 signal transduction in a wide range of tissue types...
  30. ncbi Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease
    Alina Kurylowicz
    Department of Endocrinology, Medical Research Center, Polish Academy of Science, Warsaw, Poland
    Thyroid 15:1119-24. 2005
    Recently, a functional polymorphism in the CD40 gene at position -1, C to T change (C-1T) has been identified and the C/C genotype has been reported to be associated with Graves' disease (GD).
  31. ncbi Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS)
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 151:706-11. 2006
    b>CD40/CD40L signaling is known to play an important role in immune response. The proteins are expressed in a variety of cell types and ligation causes cells to produce inflammatory cytokines and cellular adhesion molecules...
  32. ncbi CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system
    Keqiang Chen
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 201101, China
    Cell Mol Immunol 3:163-9. 2006
    b>CD40 and its cognate ligand (CD40L) are a pair of regulators of pro-inflammatory and immune responses...
  33. ncbi CD40-CD40 ligand interaction activates proinflammatory pathways in pancreatic islets
    Florencia M Barbé-Tuana
    Diabetes Research Institute, University of Miami Leonard M Miller School of Medicine, Miami, FL 33136, USA
    Diabetes 55:2437-45. 2006
    ..We recently discovered that CD40, a member of tumor necrosis factor (TNF) receptor family, is expressed in pancreatic beta-cells...
  34. ncbi Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE
    Ju Hyun Park
    Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Hospital, Jung Dong, Wonmi Ku, Bucheon, Gyeonggi Do, Republic of Korea
    Am J Respir Crit Care Med 175:775-82. 2007
    The CD40 protein plays important roles in cell-mediated and humoral immune responses, especially in immunoglobulin class-switching to IgE.
  35. ncbi A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression
    E M Jacobson
    Division of Endocrinology, University of Cincinnati College of Medicine, Vontz Center of Molecular Medicine, Cincinnati, OH 45267, USA
    Genes Immun 8:205-14. 2007
    ..others have demonstrated the association of a C/T single nucleotide polymorphism (SNP), in the Kozak sequence of CD40, with Graves' disease (GD)...
  36. ncbi CD40-40L signaling in vascular inflammation
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 282:18307-17. 2007
    Ligation of CD40 in circulating cells or in the vessel wall may promote mononuclear cell recruitment, participate in the weakening of the plaque, and contribute to thrombosis...
  37. ncbi [Correlation of CD40 gene polymorphisms with acute coronary syndrome, hypertension and diabetes]
    Yan Li
    Department of Clinical Laboratory Science, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Zhonghua Yi Xue Za Zhi 87:690-4. 2007
    To investigate the correlation of CD40-E1SNP (-1C/T) and CD40-E4SNP with acute coronary syndrome (ACS), hypertension and diabetes in Chinese Han population.
  38. doi CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling
    Raquel Pluvinet
    Medical and Molecular Genetics Center, Institut d Investigació Biomèdica de Bellvitge IDIBELL, Hospital Duran i Reynals, L Hospitalet de Llobregat, Barcelona, Spain
    Blood 112:3624-37. 2008
    ..To delineate comprehensively the involvement of CD40 (TNFRSF5) in EC activation, we combined RNAi-mediated CD40 knockdown with comparative genome-wide transcriptional ..
  39. pmc CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1
    Aristides Moschonas
    Division of Basic Sciences, University of Crete Medical School, Heraklion, Crete, Greece
    Mol Cell Biol 28:6208-22. 2008
    ..In this study, we demonstrate that CD40 ligation overcomes this defect through the coordinated action of the transcription factors NF-kappaB and interferon ..
  40. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..We identified a common variant at the CD40 gene locus (rs4810485, P = 0.0032 replication, P = 8.2 x 10(-9) overall, OR = 0.87)...
  41. pmc Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study
    Gisela Orozco
    Epidemiology Unit, Faculty of Medical and Human Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 69:813-6. 2010
    ..association studies (GWAS) in populations of European descent reported novel associations of markers mapping to the CD40, CCL21 and CDK6 genes with rheumatoid arthritis (RA) susceptibility while a large-scale, case-control association ..
  42. doi A novel mutation in CD40 and its functional characterization
    Chun Jian Qi
    Medical Biotechnology Institute and Clinical Immunology Laboratory for Jiangsu Province, Soochow University, Suzhou, China
    Hum Mutat 30:985-94. 2009
    b>CD40 is a costimulatory protein expressed on the surface of many different cells. It delivers signals regulating diverse cellular responses, including proliferation, differentiation, growth suppression, and cell death...
  43. doi A common polymorphism in CD40 Kozak sequence (-1C/T) is associated with acute coronary syndrome
    Caixia Tian
    Department of Clinical Laboratory Science, Renmin Hospital, Yunyang Medical College, Shiyan, Hubei, PR China
    Biomed Pharmacother 64:191-4. 2010
    Evidence suggests the CD40-CD40L pathway as a key process in the development, progression, and outcome of acute coronary syndrome (ACS)...
  44. pmc Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers
    Darren Plant
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1548-53. 2010
    ..Genome-wide association studies have identified non-human leucocyte antigen RA susceptibility loci which associate with RA with low-to-moderate risk...
  45. doi CD40-1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke
    Alberto del Rio-Espinola
    Neurovascular Research Laboratory, Institut de Recerca, Hospital Vall d Hebron, Pg Vall d Hebron 119 129, 08035, Barcelona, Spain
    Pharmacogenomics 11:763-72. 2010
    ..To find genetic predictors of reocclusion after successful fibrinolytic therapy during the acute phase of ischemic stroke...
  46. doi Influence of CD40 rs1883832 polymorphism in susceptibility to and clinical manifestations of biopsy-proven giant cell arteritis
    Luis Rodríguez-Rodríguez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC and Department of Internal Medicine, Hospital Clinico San Cecilio, Granada, Spain
    J Rheumatol 37:2076-80. 2010
    To assess the potential association between CD40 rs1883832 polymorphism and biopsy-proven giant cell arteritis (GCA)...
  47. doi Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway
    Daniel Yacoub
    Laboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Montreal, Quebec, Canada
    Arterioscler Thromb Vasc Biol 30:2424-33. 2010
    b>CD40 ligand is a thromboinflammatory molecule that predicts cardiovascular events...
  48. doi The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study
    Ming Wang
    Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China
    DNA Cell Biol 30:173-8. 2011
    ..A functional polymorphism (-1C>T, rs1883832) in the 5' untranslated region of TNFRSF5 gene has been reported to affect CD40 expression and be associated with several chronic inflammatory and ..
  49. pmc Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent apoptosis, but are insensitive to direct activation with exogenous Fas ligand
    Elizabeth H Humphreys
    Centre for Liver Research, MRC Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 5:e14037. 2010
    ..tightly regulated via co-operative interactions between two tumour necrosis family (TNF) receptor family members; CD40 and Fas (CD95)...
  50. doi CD40 signal expression in gastric cancer tissue and its correlation with prognosis of gastric cancer patients
    Rui Li
    Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Key Laboratory of Medicine and Clinical Immunology of Jiangsu Province, Suzhou 215006, China
    Mol Biol Rep 39:8741-7. 2012
    b>CD40 signaling plays a critical role in the survival rate of gastric cancer patients...
  51. pmc Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients
    Mercedes García-Bermúdez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, IPBLN C S I C, Granada, Spain
    PLoS ONE 7:e49214. 2012
    ..Since CD40-CD154 binding has direct consequences on inflammation process initiation, we aimed to replicate previous findings ..
  52. doi Association of CD40--1C/T polymorphism with cerebral infarction susceptibility and its effect on sCD40L in Chinese population
    Bikui Zhang
    Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China
    Int Immunopharmacol 16:461-5. 2013
    This study aims to determine whether functional polymorphism of CD40 is associated with the cerebral infarction (CI) susceptibility, and to investigate the effect of CD40 gene polymorphism on CD40 mRNA expression in PBMCs and plasma ..
  53. ncbi TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages
    Lata Mukundan
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Immunol 174:1081-90. 2005
    The interaction between CD40 and its ligand, CD154, has been shown to play a role in the onset and maintenance of inflammatory disease...
  54. ncbi Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling
    B S Hostager
    Departments of Microbiology and Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 275:15392-8. 2000
    Signals delivered to antigen-presenting cells through CD40 are critical for the activation of immune responses...
  55. pmc Regulation of CD40 function by its isoforms generated through alternative splicing
    M Tone
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 98:1751-6. 2001
    b>CD40 is a member of the tumor necrosis factor receptor superfamily...
  56. pmc Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis
    F Mach
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:1931-6. 1997
    Increasing evidence supports involvement of inflammation and immunity in atherogenesis. We report here that CD40 ligand (CD40L), an immunoregulatory signaling molecule heretofore considered largely restricted to recently activated CD4+ T ..
  57. ncbi Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in Japanese
    Yoshiyuki Ban
    Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Thyroid 16:443-6. 2006
    ..Furthermore, a novel single nucleotide polymorphism (SNP) in the CD40 gene, which is located in 20q11, was found to be associated and linked with GD in Caucasians and in Koreans.
  58. ncbi The CD40-induced protection against CD95-mediated apoptosis is associated with a rapid upregulation of anti-apoptotic c-FLIP
    Jonna Eeva
    Department of Clinical Microbiology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Mol Immunol 44:1230-7. 2007
    CD95/Fas and CD40 receptors are important regulators of cell survival during germinal center reaction...
  59. ncbi Analysis of the C/T(-1) single nucleotide polymorphism in the CD40 gene in multiple sclerosis
    D Buck
    Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Department of Neurology, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    Tissue Antigens 68:335-8. 2006
    The costimulatory CD40-CD40L pathway plays a critical role in the generation and maintenance of adaptive immune responses...
  60. pmc Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK
    Yun Jung Ha
    Division of Life and Pharmaceutical Sciences, Department of Life Science, College of Natural Sciences, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
    Exp Mol Med 43:101-10. 2011
    Previously, we reported that CD40-induced production of reactive oxygen species (ROS) by NADPH oxidase requires the TNF receptor-associated factor (TRAF) 3, as well as the activities of phosphatidylinositol 3-kinase (PI3K) and Rac1...
  61. pmc Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia
    Peter Chu
    The Chronic Lymphocytic Leukemia Research Consortium, Biomedical Sciences Graduate Program, Division of Hematology Oncology, Stein Institute for Research on Aging, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0663, USA
    Proc Natl Acad Sci U S A 99:3854-9. 2002
    ..CD4 T cell lines can induce apoptosis of CD40-activated CLL cells via a CD95 ligand (CD95-L)-dependent mechanism...
  62. ncbi The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase
    Jesse A Flaxenburg
    Division of Nephrology, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Immunol 172:7503-9. 2004
    Ligation of endothelial cell (EC) CD40 induces the expression of several proinflammatory cytokines as well as angiogenesis factors, including vascular endothelial growth factor (VEGF)...
  63. pmc CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells
    Jian Zheng
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Cell Mol Immunol 7:44-50. 2010
    ..Both CD40-activated B cells (CD40-B) and immature dendritic cells (imDCs) have been used as professional antigen-presenting ..
  64. pmc A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis
    Alexandra Nieters
    Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 128:1481-5. 2011
    ..studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma...
  65. doi Polymorphisms of the genes encoding CD40 and growth differentiation factor 15 and in the 9p21.3 region in patients with rheumatoid arthritis and cardiovascular disease
    Lisbeth Arlestig
    Department of Public Health and Clinical Medicine, Rheumatology, Umea University, Umea, Sweden
    J Rheumatol 39:939-45. 2012
    ..Genes or gene products associated with coronary artery disease in the general population were analyzed in rheumatoid arthritis (RA) patients with atherothrombotic manifestations (ATM)...
  66. pmc A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas
    I Stamenkovic
    Department of Genetics, Harvard Medical School, Boston, MA
    EMBO J 8:1403-10. 1989
    B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B-cell maturation and epithelial neoplasia...
  67. ncbi Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells
    S H Hanissian
    Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 6:379-87. 1997
    b>CD40 is a receptor that is critical for the survival, growth, differentiation, and isotype switching of B lymphocytes...
  68. ncbi Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth
    Amanda J Baxendale
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TA, UK
    Oncogene 24:7913-23. 2005
    b>CD40, a tumour necrosis factor (TNF) receptor family member, is expressed in a variety of cell types, including B lymphocytes, macrophages, fibroblasts, endothelial and epithelial cells, and this widespread expression is likely to account ..
  69. pmc C4b binding protein binds to CD154 preventing CD40 mediated cholangiocyte apoptosis: a novel link between complement and epithelial cell survival
    Kevin T Williams
    The Liver Research Group and MRC Centre for Immune Regulation, Institute of Biomedical Research, The University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 2:e159. 2007
    Activation of CD40 on hepatocytes and cholangiocytes is critical for amplifying Fas-mediated apoptosis in the human liver...
  70. pmc A novel polymorphism of the human CD40 receptor with enhanced function
    Anna L Peters
    Medical Scientist Training Program, University of Iowa, Iowa City, IA 52242, USA
    Blood 112:1863-71. 2008
    b>CD40 signaling is critical for innate and adaptive immunity against pathogens, and the cytoplasmic domain of CD40 is highly conserved both within and between species...
  71. doi Expression of CD40 and growth-inhibitory activity of CD40 ligand in colon cancer ex vivo
    Yugang Wu
    Department of Surgery, The First People Hospital of Changzhou and The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, China
    Cell Immunol 253:102-9. 2008
    b>CD40, a member of the tumor necrosis factor receptor superfamily, is widely expressed on various cell types. Some studies show that CD40 expression is related to several carcinomas, where its function remains largely unknown...
  72. pmc CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility
    Fiona Blanco-Kelly
    Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain
    PLoS ONE 5:e11520. 2010
    A functional polymorphism located at -1 from the start codon of the CD40 gene, rs1883832, was previously reported to disrupt a Kozak sequence essential for translation...
  73. pmc Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China
    Chen Shuang
    Department of Immunology, Harbin Medical University, Harbin, China
    PLoS ONE 6:e23762. 2011
    ..The co-stimulatory molecule CD40 plays a prominent role in immune regulation and homeostasis...
  74. ncbi A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes
    S Paulie
    Cancer Immunol Immunother 20:23-8. 1985
    ..A possible relation of the S2C6 antigen to a receptor for B cell growth factors is discussed...
  75. ncbi Coculture of human liver macrophages and cholangiocytes leads to CD40-dependent apoptosis and cytokine secretion
    Edward B Alabraba
    Liver Research Group, University of Birmingham, Birmingham, UK
    Hepatology 47:552-62. 2008
    ..We have previously reported that activation of CD40 on cholangiocytes with either soluble CD154 or cross-linking monoclonal antibody to CD40 induces apoptosis in vitro...
  76. ncbi A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40
    T Sato
    La Jolla Cancer Research Foundation, Oncogene and Tumor Suppressor Gene Program, CA 92037
    FEBS Lett 358:113-8. 1995
    b>CD40 is a member of the tumor necrosis factor receptor (TNF-R) family that regulates B-lymphocyte proliferation, immunoglobulin class-switching, and apoptosis through poorly defined signal transduction mechanisms...
  77. ncbi Proangiogenic function of CD40 ligand-CD40 interactions
    Marlies E J Reinders
    Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 171:1534-41. 2003
    ..However, little is known of the immunologic mediators of angiogenesis factor production. Interactions between CD40 ligand (CD40L) and CD40 have been shown to have pluripotent functions in inflammation, including the production of ..
  78. pmc A functional TNFRSF5 gene variant is associated with risk of lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Blood 111:4348-54. 2008
    ..We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5 and TNFSF5 encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional ..
  79. ncbi [Immunoglobulin production by human peripheral B cells against Staphylococcus aureus]
    T Miyashita
    Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Kansenshogaku Zasshi 72:1269-74. 1998
    ..In the presence of interleukin-2 (IL-2) or supplemental recombinant CD40 ligand plus IL-2, Ig production by SAC-induced B cells was dramatically enhanced...
  80. ncbi CD154 (CD40 ligand)
    U Schonbeck
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Int J Biochem Cell Biol 32:687-93. 2000
    b>CD40 ligand, a type II transmembrane protein recently renamed CD154, was originally considered restricted to activated T lymphocytes, functioning as a mediator of T cell-dependent B cell activation, proliferation, and differentiation...
  81. ncbi CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4
    Seema S Ahuja
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Endocrinology 144:1761-9. 2003
    ..It was observed that the MLO-Y4 osteocyte-like cells express CD40 antigen and MHC class I antigen, but they are negative for a series of other dendritic cells markers (DEC-205, ..
  82. ncbi Effect of a synthetic lipid immunomodulator on the regulation of the transcription factor NF-kappaB
    S Pollet
    , La Tronche, France
    Immunopharmacol Immunotoxicol 22:653-69. 2000
    ..Antibodies to various NF-kappaB proteins supershifted p50, p65 and to a lesser extent c-rel...
  83. ncbi Dacetuzumab, a humanized mAb against CD40 for the treatment of hematological malignancies
    Sapna Khubchandani
    Roswell Park Cancer Institute, Department of Medicine and Immunology, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Curr Opin Investig Drugs 10:579-87. 2009
    Dacetuzumab, a humanized mAb targeting the CD40 antigen, is in development by Seattle Genetics Inc and licensee Genentech Inc for the potential treatment of hematological malignancies...
  84. ncbi Rapid induction of CD40 on a subset of granulocyte colony-stimulating factor-mobilized CD34(+) blood cells identifies myeloid committed progenitors and permits selection of nonimmunogenic CD40(-) progenitor cells
    D Rondelli
    Institute of Hematology and Medical Oncology, Seragnoli, University of Bologna, Bologna, Italy
    Blood 94:2293-300. 1999
    ..on dendritic cells (DC) and activated B cells, which induces T-cell proliferation through the binding with CD40L receptor. In this study, we evaluated CD40 expression on normal CD34(+) blood cells and functionally characterized CD34(..
  85. pmc A three-dimensional collagen lattice induces protein kinase C-zeta activity: role in alpha2 integrin and collagenase mRNA expression
    J Xu
    Department of Dermatology, School of Medicine, SUNY at Stony Brook, New York 11794-8165, USA
    J Cell Biol 136:473-83. 1997
    ..The composition of the NF-kappaB/Rel complexes that contained p50, was not changed...
  86. ncbi Possible role of nuclear factor-kappa B activity in germline C epsilon transcription in a human Burkitt lymphoma B cell line
    Y Yanagihara
    Clinical Research Center for Allergy, National Sagamihara Hospital, Kanagawa, Japan
    Cell Immunol 176:66-74. 1997
    ..We report here that the signaling cascade triggered by interleukin-4 (IL-4) or anti-CD40 monoclonal antibody (mAb) participates in NF-kappa B activation responsible for germline C epsilon transcription in ..
  87. ncbi Salt-induced immobilizations of DNA oligonucleotides on an epoxide-activated high-performance liquid chromatographic affinity support
    J B Wheatley
    Terrapin Technologies, South San Francisco, CA 94080, USA
    J Chromatogr A 726:77-90. 1996
    ..Purified p50 protein, the DNA binding element of NF-kappa B, and nuclear extracts from phorbol ester-stimulated HeLa cells were ..
  88. doi Regression of established AB1 murine mesothelioma induced by peritumoral injections of CpG oligodeoxynucleotide either alone or in combination with poly(I:C) and CD40 ligand plasmid DNA
    Geoffrey W Stone
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0679, USA
    J Thorac Oncol 4:802-8. 2009
    Stimulation of the CD40 receptor using an agonistic anti-CD40 antibody can slow the growth of AB1 tumors...
  89. doi Enhanced levels of soluble CD40 ligand and C-reactive protein in a total of 312 patients with metabolic syndrome
    Ilkay Tugba Unek
    Department of Internal Medicine, Dokuz Eylul University School of Medicine, 35340 Inciralti, Izmir, Turkiye
    Metabolism 59:305-13. 2010
    ..Increasing evidence indicates that CD40-CD40 ligand interactions constitute an important mediator for vascular inflammation...
  90. ncbi Abundant expression of CD40 and CD40-ligand (CD154) in paediatric Langerhans cell histiocytosis lesions
    R M Egeler
    Southern Alberta Children s Cancer Program, Alberta Children s Hospital Tom Baker Cancer Centre, Department of Oncology and Pediatrics, University of Calgary, Alberta, Calgary, Canada
    Eur J Cancer 36:2105-10. 2000
    ..The interaction between CD40 on antigen-presenting cells (APC) like Langerhans cells and CD40 ligand (CD40L) (CD154) expressed by activated CD4+ ..
  91. ncbi Analysis of the CD40/CD40L role in the sustenance of alloreactive antibody production
    A S Shoker
    Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Transpl Immunol 8:219-28. 2001
    b>CD40 ligand (CD40L) is important for T/B lymphocyte interaction...
  92. pmc CD40-CD40 ligand interactions promote trafficking of CD8+ T cells into the brain and protection against West Nile virus encephalitis
    Elizabeth Sitati
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Virol 81:9801-11. 2007
    ..Binding of CD40 by CD40 ligand (CD40L) on activated CD4+ T cells provides an important costimulatory signal for immunoglobulin ..
  93. ncbi High-sensitivity C-reactive protein and soluble CD40 ligand as indices of inflammation and platelet activation in 880 patients with nonvalvular atrial fibrillation: relationship to stroke risk factors, stroke risk stratification schema, and prognosis
    Gregory Y H Lip
    Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, England, UK
    Stroke 38:1229-37. 2007
    ..We tested the hypothesis that plasma levels of C-reactive protein (CRP; an index of inflammation) and soluble CD40 ligand (an index of platelet activation, with links to inflammation) could be related to 3 established stroke risk ..
  94. ncbi Inhibition of NF-kappaB-DNA binding by mercuric ion: utility of the non-thiol reductant, tris(2-carboxyethyl)phosphine hydrochloride (TCEP), on detection of impaired NF-kappaB-DNA binding by thiol-directed agents
    F J Dieguez-Acuna
    Department of Environmental Health, 4225 Roosevelt Way NE, Suite 100, University of Washington, Seattle, WA 98105, USA
    Toxicol In Vitro 14:7-16. 2000
    ..of nuclear factor kappaB (NF-kappaB) by mercaptide bond formation with a critical cysteine moiety (cys(62)) on the p50 subunit required for DNA binding...
  95. pmc Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
    W W Hancock
    Department of Pathology, New England Deaconess Hospital, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 93:13967-72. 1996
    Recent data implicates a role for the CD40-CD40 ligand (CD40L) pathway in graft rejection. One potential mechanism is direct costimulation of T cells through CD40L...
  96. ncbi Expression of CD23/CD21 and CD40/CD40 ligand in vernal keratoconjunctivitis
    A M Abu El-Asrar
    Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Eye (Lond) 15:217-24. 2001
    ..CD23/CD21 and CD40/CD40 ligand (CD40L) interactions have been proposed to be involved in the regulation of IgE synthesis...
  97. ncbi Multivalent, but not divalent, antigen receptor cross-linkers synergize with CD40 ligand for induction of Ig synthesis and class switching in normal murine B cells. A redefinition of the TI-2 vs T cell-dependent antigen dichotomy
    C M Snapper
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814
    J Immunol 154:1177-87. 1995
    ..Previous work also indicated a critical role, in these responses, for CD40-mediated signaling mediated by binding of the inducible T cell membrane protein, CD40 ligand (CD40L)...
  98. ncbi The CD40 ligand expressed by human B cells costimulates B cell responses
    A C Grammer
    Immunology Graduate Program, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 154:4996-5010. 1995
    The possibility that activated B cells might express a ligand for CD40 that was of functional importance for B cell responses was examined by using highly purified human peripheral blood B cells, as well as a variety of B lymphoblastoid ..
  99. ncbi CD40-CD40 ligand interactions stimulate B cell antigen processing
    A E Faassen
    Department of Biochemistry, Molecular Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Eur J Immunol 25:3249-55. 1995
    The interactions between B cell CD40 and T cell CD40 ligand (CD40L) have been shown recently to play an important role in T cell-dependent activation of B cells...

Research Grants66

  1. PROLIFERATIVE CONDITIONING OF TUMOR-COMPETENT DENDRITIC CELL PRECURSORS
    Peter A Cohen; Fiscal Year: 2010
    ..and IL-12p70 secretion;(3) it licenses spontaneous DC maturation, bypassing normal requirements for signals such as CD40 ligand or toll-like receptor (TLR) agonists;(4) it confers resistance to tumor-associated immunosuppressants such ..
  2. Targeted Dendritic Cell Activation through Multi-Adjuvant Liposomes
    Gretchen Jimenez; Fiscal Year: 2013
    ..innovation is a dual adjuvant system where VesiVax(R) lipid vesicles are formulated with a TLR9 agonist (CpG) and CD40 Ligand fused to the Company's proprietary Hydrophobic Domain (HD) technology...
  3. Combination gene therapy for metastatic colon cancer
    Shu Hsia Chen; Fiscal Year: 2010
    ..Furthermore, agonistic anti-CD40 antibody prevented MSC-mediated Treg induction...
  4. RICHARD SYD KORNBLUTH; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): CD40 ligand (CD40L or CD154) is widely recognized as one of the most important endogenous activators of the immune system...
  5. Targeted Gene Therapy for Lymphoma
    Bruce F Smith; Fiscal Year: 2010
    ..We propose a novel approach to redirect a virus to target lymphoma using CD40 and CD40 ligand. This approach will be tested in spontaneous canine lymphoma, a rigorous model of the human disease...
  6. QIZHI C YAO; Fiscal Year: 2015
    ..We have developed and characterized chimeric CD40 ligand/simian-human immunodeficiency (CD40L/SHIV) virus-like particles (VLPs) which possess the antigen presenting ..
  7. Otoniel Martinez-Maza; Fiscal Year: 2016
    ..We also found that HIV virions carrying CD40 ligand (CD40L), a T cell-produced B cell stimulatory molecule, can drive B cell activation and AICDA expression...
  8. Positive and Negative Regulatory Pathways In Human Lymphoma
    Richard Ford; Fiscal Year: 2007
    ..growth characteristics, while retaining typical B cell immuno-phenotypes, including expression of characteristic CD40 and SIg. cell surface receptors...
  9. Yuri Persidsky; Fiscal Year: 2016
    ..We uncovered molecular mechanisms of BBB dysfunction [tight junction (TJ) phosphorylation, CD40/CD40 ligand interactions at BBB and signaling events behind the direct effects of HIV on brain endothelium]...
  10. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..additional source of OPG in vivo, and that B cell OPG production is regulated by costimulatory signals such as CD40 Ligand (CD40L) derived from T cells...
  11. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..and hemostasis (hsCRP, MCP-1, IL-6, sTNFRII, sVCAM-1, sICAM-1, serum amyloid A, MMP-9, E-selectin, P-selectin, CD40 ligand, fibrinogen, von Willebrand factor, and D-dimer)...
  12. MOLECULAR AND CELLULAR REGULATION OF TOLERANCE
    Yongwon Choi; Fiscal Year: 2010
    ..We believe the third goal is a logical extension of this work because TRAF6 is a key signal transducer for CD40 and IL-1/Toll-like receptors...
  13. Manipulation of Follicular Helper T Cells in Immunity and Autoimmunity
    Joseph Craft; Fiscal Year: 2013
    ..In GCs, T follicular helper (Tfh) cells provide B cells with survival and differentiation signals, including CD40 ligand (CD40), programmed death receptor-1 (PD-1), and IL-21, essential for B cell selection with maturation into ..
  14. Vince N Montes; Fiscal Year: 2014
    ..Other co-stimulatory pathways that may be synergistic include the CD40-CD40L pathway. T cell activation is highly dependent on the co- stimulatory actions of these pathways...
  15. Identification and Significance of Biologic Mediators in Red Cell Concentrates
    Richard P Phipps; Fiscal Year: 2012
    ..Laboratory measures include CD40 ligand, C-reactive protein, D-dimer, blood cell count and differential...
  16. ANTIBODY V GENE EXPRESSION B CELL LYMPHOCYTIC LEUKEMIA
    Thomas J Kipps; Fiscal Year: 2013
    ..of strategies for inducing anti- leukemia immune responses via the use of CLL cells that are activated via CD40-ligation...
  17. Mechanisms of CD40/CD40L in vascular injury and repair
    Guohong Li; Fiscal Year: 2013
    ..Abundant evidence indicates that the CD40-CD40 ligand (CD40L) pathway plays a pivotal role in immune and inflammatory responses...
  18. MICHELLE MEGAN KIEBALA; Fiscal Year: 2014
    ..that HIV infection is associated with increased levels of molecules known to activate platelets, including soluble CD40 ligand (sCD40L), and platelet activating factor (PAF)...
  19. Phase I, Open-Label Dose-Escalation
    Januario E Castro; Fiscal Year: 2010
    ..clinical activity of a new modality of immuno-gene therapy mediated by transduction of leukemia cells with CD154 (CD40 Ligand) using direct intra-lymph node (intranodal) injection of a replication-defective adenovirus vector that ..
  20. LORI RUTH COVEY; Fiscal Year: 2014
    ..Historically, there has been a widespread appreciation of the functional significance of interactions between CD40 ligand (CD40L, CD154) on activated CD4+ T cells and CD40 expressed on antigen presenting cells (APC) in both ..
  21. David Gozal; Fiscal Year: 2014
    ..we will examine IL-6, TNF-1, and ApoE polymorphisms, as well as plasma levels of IL-6, TNF-1 , soluble CD40 ligand, and high sensitivity CRP, and adipokines such as leptin, adiponectin, resistin, visfatin, and ghrelin...
  22. Development of Immunotherapeutic Strategies in the Treatment of Lung Cancer
    Scott J Antonia; Fiscal Year: 2012
    ..The vaccines are (1) a dendritic cell-based vaccine using p53 as the tumor antigen, and (2) a GM-CSF and CD40 ligand-expressing bystander cell line admixed with tumor cells as the source of tumor antigens...
  23. CD40 and TLR Agonists in Melanoma
    Jeffrey S Weber; Fiscal Year: 2010
    ..An important molecule involved in T cell regulation is CD40 which is expressed on antigen-presenting cells and B cells...
  24. WILLIAM CHARLES SPANOS; Fiscal Year: 2015
    ..Modalities include optimizing radiation dosing for clearance and determining whether CD40 ligand modulation of the immune system improves tumor clearance...
  25. HUMAN B CELL DIFFERENTIATION IN A MODEL SYSTEM
    LORI COVEY; Fiscal Year: 2009
    ..A critical molecule in this regard is the CD40 ligand (CD40L, CD154), which is expressed on activated T cells and through its interaction with CD40 on B cells, ..
  26. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2003
    ..of T and B cells is dependent upon the interaction of the TCR/MHC as well as co-stimulatory molecules, including CD40-CD40L...
  27. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2005
    ..of T and B cells is dependent upon the interaction of the TCR/MHC as well as co-stimulatory molecules, including CD40-CD40L...
  28. INTERLEUKIN 12 AS IMMUNOTHERAPY IN LEISHMANIASIS
    FREDERICK HEINZEL; Fiscal Year: 2001
    ..infection in leishmaniasis to investigations on how IL-12 is regulated by the accessory cell receptor protein, CD40. CD40 is activated by antigen-specific T cells bearing the CD40 ligand and induces IL-12 necessary for Th1 CD4+ ..
  29. HIV-1 DNA VACCINES THAT TARGET AND ACTIVATE CD40
    JEFFREY LEDBETTER; Fiscal Year: 2001
    ..We propose to utilize CD40 activation and targeting in an attempt to improve the ability of HIV-1 env DNA vaccines to generate strong cellular ..
  30. Using Genechips to Study the Immunological Roles of CD40
    Genhong Cheng; Fiscal Year: 2005
    DESCRIPTION (Provided by the Applicant): CD40, a member of the tumor necrosis factor receptor (TNFR) superfamily, is expressed on the surface of B-cells, activated macrophages, epithelial cells, dendritic cells and a variety of tumor ..
  31. REDUCED CYTOKINE PRODUCTION BY NEONATAL T CELLS
    David Lewis; Fiscal Year: 2000
    DESCRIPTION (Adapted from Applicant's Description): The CD40-ligand (CD40-L) is a T cell-derived cytokine that, via its interaction with CD40, provides critical signals for B cell antibody production and isotype switching, and priming of ..
  32. AKNA, germinal center reaction and immunity.
    Hector Martinez Valdez; Fiscal Year: 2007
    ..B cell activation requires cognate receptor/ligand interactions, among which, the ligation of B cetl- CD40 by the T celI-CD40 ligand (CD154) provides the essential stimuli for cell proliferation, survival, and induction of ..
  33. CONTROL OF SWITCH RECOMBINATION BY CD40 LIGAND
    MICHAEL BERTON; Fiscal Year: 2000
    ..T-cell contact-dependent signals required for isotype switching are provided by the CD40 ligand (CD40L)-CD40 interaction, but nothing is known about how these signals regulate isotype switching...
  34. Role of the CD40/CD40L dyad in atherosclerosis
    Masanori Aikawa; Fiscal Year: 2006
    ..Previous work by the applicants established a prominent role of the CD40/CD40 ligand (CD40L) dyad in atherogenesis in vitro and in vivo, and furthermore identified the interruption of CD40/..
  35. Role of Aryl hydrocarbon receptor (AhR) and RelB during the initiation of dendrit
    Christoph F A Vogel; Fiscal Year: 2010
    ..response of the DCs based on the measurement of selected activation markers such as surface expression of CD1a, CD40, CD80, CD86 and MHCII by flow cytometry and chemokines relevant for the function of DCs like DC-CK1, DC-STAMP, and ..
  36. Role of B cells in host defense against Pneumocystis
    Beth A Garvy; Fiscal Year: 2012
    ..murine models, we have found that B-T cell interactions through costimulatory molecules such as MHC class II and CD40 on B cells have profound effects on T cell function...
  37. Dendritic Cells, Rapamycin and Transplant Tolerance
    Angus W Thomson; Fiscal Year: 2010
    ..action on T cell growth, stably suppresses DC maturation, inhibiting their responses to Toll-receptor and CD40 ligation and pro-inflammatory cytokines...
  38. HSV encoded viral functions
    Bin He; Fiscal Year: 2012
    ..In this process, co-stimulatory molecules such as MHC class II, CD40, CD80, and CD86 are up-regulated...
  39. FOLLICULAR ANTIGEN BINDING DENDRITIC CELLS
    John Tew; Fiscal Year: 2009
    ..we believe are important in FDC-B cell-T cell interactions including: Ag-Ab complexes, CD21L, CD23, CD32/FcyRIIB, CD40, CD44, CD54/ICAM-1, CD106/VCAM-1, and CD320/8D6;3) Products secreted by FDCs that influence GC reactions include ..
  40. Role of Infiltrating CD4+ T Lympoocytes in Neuropathic Pain
    Ling Cao; Fiscal Year: 2010
    ..a model system for investigating possible adaptive immune response-related therapeutic targets (such as CD40-CD40L blockade) in neuropathic pain...
  41. Enhancement of Dendritic Cells for Improved Immunotherapy
    David Spencer; Fiscal Year: 2009
    ..These include engineering a drug-inducible CD40 (iCD40) receptor that permits temporally controlled DC-specific activation within the context of an immunological ..
  42. Dorothy J Becker; Fiscal Year: 2016
    ..treated ex vivo with antisense phosphorothioate-modified oligonucleotides targeting the primary transcripts of the CD40, CD80 and CD86 co-stimulatory molecules (immunoregulatory DC;iDC)...
  43. OVARIECTOMY UPREGULATES BONE TURNOVER THROUGH T CELL-STROMAL CROSSTALK
    Roberto Pacifici; Fiscal Year: 2012
    ..SC production of osteoclastogenic cytokines, and promote SC differentiation into OBs through stimulation of CD40 signaling in SCs by T cell expressed CD40L...
  44. Targeting mTOR and CD40 Pathways for Adjuvanting HIV Vaccines
    Rama Rao Amara; Fiscal Year: 2013
    ..In this HIVRAD, we will use molecules that target mTOR (mammalian target of rapamycin) and CD40 pathways as novel adjuvants to elicit high levels of polyfunctional virus-specific CD8 T cells, CD4 T cells that ..
  45. A New Anti-CD27 Monoclonal Antibody Adjuvant for Pancreatic Cancer Vaccines
    SARAH JANE SCHLESINGER; Fiscal Year: 2013
    ..Anti-CD27 will also be compared to the combination of poly IC and agonistic anti-CD40, a combination that is the most powerful known inducer of CD70 expression on DCs...
  46. Harnessing Human DC Subsets for Improved Muscosal Vaccines
    Gerard Zurawski; Fiscal Year: 2013
    ..antibody a) binding to two different cell surface antigens, such as specific lectin for antigen delivery and CD40 for activation, or to two different DC subsets, to harness their capacity to induce different type of immune ..
  47. Sandra J Gendler; Fiscal Year: 2015
    ..However, the function of old DCs could be restored if old DCs were stimulated with CpG-ODN plus anti-CD40. Additionally, our results indicate that a higher number of old naive CD8+ T cells express B7-H1...
  48. The Role of DC's Tolerance
    Shoshana Katzman; Fiscal Year: 2010
    ..We will address whether activation signals such as CpG-oligonucleotides or anti-CD40 signaling are enough to change the status of the DC's and break tolerance...
  49. Innate immunity and dendritic cells in cryptosporidiosis
    SAUL R TZIPORI; Fiscal Year: 2010
    ..produced by dendritic cells, is critical in controlling Cryptosporidium infection, and 3) bone marrow-derived CD40-positive cells are required for mice to clear C. parvum infection...
  50. Clustered receptor-signaling domains as novel HIV vaccine genetic adjuvants
    GEOFFREY WILLIAM STONE; Fiscal Year: 2012
    ..Other models have shown protection from tumor challenge with mixtures of TLR7 agonists and CD40 stimulation...
  51. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2011
    ..g. CD86 and CD40) in iNOS-/- mice compared to WT mice out to day 7 after injury...
  52. Advanced Design of a Nicotine Vaccine for Smoking Cessation
    Christopher H Clegg; Fiscal Year: 2013
    ..We hypothesize that targeted nicotine delivery to dendritic cells using agonistic mAbs to CD40 combined with a TLR4-based adjuvant will stimulate a superior antibody response...
  53. Franco R D'Alessio; Fiscal Year: 2014
    ..g. CD86 and CD40) in iNOS-/- mice compared to WT mice out to day 7 after injury...
  54. Dendritic cells in psoriasis and effects of efalizumab
    Michelle A Lowes; Fiscal Year: 2010
    ..anti-CD11a) for psoriasis, we identified a new type of cutaneous dendritic cell (DC) (CD11c+, HLA-DR+, CD86+, CD40+), which constitutes the most abundant type of leukocyte in psoriasis lesions...
  55. Implication of HUCBC: a novel therapeutic strategy for Alzheimer's disease
    Jun Tan; Fiscal Year: 2013
    ..In addition we recently demonstrated sera derived from HUCBC-infused PSAPP mice significantly inhibited microglial CD40 expression induced by IFN-? and markedly increased microglial A[unreadable] phagocytic activity without ..
  56. Yong Jun Liu; Fiscal Year: 2014
    ..and knocking down DHX9 expression was associated with a diminished TNF and IL-6 response and blocking of NF-kB p50 nuclear translocation induced by to CpG-B. The DExD/H helicase family has over 50 members...
  57. Boosting therapeutic immunity against Ovarian Cancer through CD40/TLR agonists
    UCIANE KIMBLE SCARLETT; Fiscal Year: 2010
    ..The specific aims of the project are: 1. Determine how CD40/TLR agonists impact the immune response against ovarian cancer. 2...
  58. Gourisankar Ghosh; Fiscal Year: 2016
    ..The combinatorial NF-?B dimers are formed from five family members;p50, p52, RelA (p65), cRel and RelB...
  59. Gourisankar Ghosh; Fiscal Year: 2015
    ..NF-?B1 (also called p105/p50) and NF-?B2 (also called p100/p52) belong to both the NF-?B and I?B families...
  60. Perfluorooctane Sulfonate (PFOS) affects 1gM Production via IL-2
    Margie M Peden Adams; Fiscal Year: 2010
    ..We have also shown that alterations in IL-4, IL-5, IL-6 and CD40, CD154 expression and signalling are not related to suppression of IgM production...
  61. Anna K Mapp; Fiscal Year: 2016
    ..small (drug-like) molecules that inhibit the function of two transcriptional activators, ESX and NF- kappaB (p50/p65 heterodimer) implicated in approximately 30% of breast cancers...
  62. Use p105(sr) to study p50 homodimer in skin tumor/cancer
    Li Lin; Fiscal Year: 2009
    ..However, unlike other types of cancers where NF-kappaB heterodimer p50/RelA activity is elevated, chemical-induced skin papillomas and squamous cell carcinomas (SCC), exhibit ..
  63. Nonviral Gene Medicine for Hemophilia A
    Carol H Miao; Fiscal Year: 2010
    ..and the best strategy of blocking the co-stimulation pathway using a combination of Ctla4-Ig and anti-murine CD40 ligand mAb (MR1) induced long- term tolerance to factor VIII in mice...
  64. ROLE OF CD40-CD40 LIGAND IN PRIMARY BILIARY CIRRHOSIS
    MARLYN MAYO; Fiscal Year: 2003
    ..is that T cells orchestrate the immune attack on cholangiocytes via signaling to other cells in the liver through CD40 ligand...
  65. HTLV Deregulation of CD40(L) in Cancer&Neurodegeneration
    Edward Harhaj; Fiscal Year: 2007
    ..This proposal is centered on the deregulated expression of CD40 Ligand (CD40L) and its receptor CD40 in HTLV-l-infected T cells...
  66. DIFFERENTIATION AND FUNCTION OF HUMAN HELPER T CELLS
    SETH LEDERMAN; Fiscal Year: 2000
    ..The progress from our lab and others has demonstrated that the CD4+ T cell surface protein, CD40-ligand (CD40-L)(previously termed 5c8 Ag or T-BAM in this grant) and its receptor, CD4O, play important roles in ..