CD36

Summary

Gene Symbol: CD36
Description: CD36 molecule
Alias: BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, platelet glycoprotein 4, CD36 antigen (collagen type I receptor, thrombospondin receptor), CD36 molecule (thrombospondin receptor), GPIIIB, PAS IV, PAS-4 protein, cluster determinant 36, fatty acid translocase, glycoprotein IIIb, leukocyte differentiation antigen CD36, platelet glycoprotein IV, scavenger receptor class B, member 3
Species: human

Top Publications

  1. ncbi Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases
    Miyako Yuasa-Kawase
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 19:263-75. 2012
  2. ncbi Chemical modifications of band 3 protein affect the adhesion of Plasmodium falciparum-infected erythrocytes to CD36
    Enrique Winograd
    Department of Biology, University of California, Riverside, CA 92521, USA
    Mol Biochem Parasitol 136:243-8. 2004
  3. doi CD36 deficiency protects against malarial anaemia in children by reducing Plasmodium falciparum-infected red blood cell adherence to vascular endothelium
    Jaffu Chilongola
    Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical College, Moshi, Tanzania
    Trop Med Int Health 14:810-6. 2009
  4. pmc Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis
    Richard F Collins
    Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 284:30288-97. 2009
  5. pmc Plasmodium falciparum-induced CD36 clustering rapidly strengthens cytoadherence via p130CAS-mediated actin cytoskeletal rearrangement
    Shevaun P Davis
    Department of Microbiology, Immunology, and Infectious Diseases, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    FASEB J 26:1119-30. 2012
  6. ncbi Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    FASEB J 18:1144-6. 2004
  7. ncbi Malaria susceptibility and CD36 mutation
    T J Aitman
    MRC Clinical Sciences Centre, and Imperial College Genetics and Genomics Research Institute, Hammersmith Hospital, London, UK
    Nature 405:1015-6. 2000
  8. pmc CD36 polymorphism is associated with protection from cerebral malaria
    Kazuya Omi
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Hum Genet 72:364-74. 2003
  9. ncbi CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes
    Akihiko Kuniyasu
    Department of Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5 1 Ohe Honmachi, Japan
    FEBS Lett 537:85-90. 2003
  10. pmc CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions
    Fabienne Laugerette
    Physiologie de la Nutrition, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation et Centre Européen des Sciences du Goût, UMR 5170 CNRS 1214 INRA Université de Bourgogne, Dijon, France
    J Clin Invest 115:3177-84. 2005

Detail Information

Publications282 found, 100 shown here

  1. ncbi Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases
    Miyako Yuasa-Kawase
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    J Atheroscler Thromb 19:263-75. 2012
    ..A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids...
  2. ncbi Chemical modifications of band 3 protein affect the adhesion of Plasmodium falciparum-infected erythrocytes to CD36
    Enrique Winograd
    Department of Biology, University of California, Riverside, CA 92521, USA
    Mol Biochem Parasitol 136:243-8. 2004
    ..anion exchanger, band 3 protein (AE1), in the adhesion of Plasmodium falciparum-infected erythrocytes to CD36 and thrombospondin (TSP) was studied...
  3. doi CD36 deficiency protects against malarial anaemia in children by reducing Plasmodium falciparum-infected red blood cell adherence to vascular endothelium
    Jaffu Chilongola
    Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical College, Moshi, Tanzania
    Trop Med Int Health 14:810-6. 2009
    b>CD36 is a receptor that occurs on the surface of activated immune cells, vascular endothelial cells and participates in phagocytosis and lipid metabolism...
  4. pmc Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis
    Richard F Collins
    Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 284:30288-97. 2009
    The class B scavenger receptor CD36 has numerous ligands that include modified forms of low density lipoprotein, fibrillar amyloid, apoptotic cells, and Plasmodium falciparum-infected red blood cells, linking this molecule to ..
  5. pmc Plasmodium falciparum-induced CD36 clustering rapidly strengthens cytoadherence via p130CAS-mediated actin cytoskeletal rearrangement
    Shevaun P Davis
    Department of Microbiology, Immunology, and Infectious Diseases, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    FASEB J 26:1119-30. 2012
    ..cells generated a mean ± sd adhesion force of 167 ± 208 pN from the formation of single or multiple bonds with CD36. The strength of adhesion increased by 5- to 6-fold within minutes of contact through a signaling pathway initiated ..
  6. ncbi Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    Arend Bonen
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    FASEB J 18:1144-6. 2004
    ..individuals, the increased sarcolemmal LCFA transport rate was not associated with an altered expression of FAT/CD36 or FABPpm...
  7. ncbi Malaria susceptibility and CD36 mutation
    T J Aitman
    MRC Clinical Sciences Centre, and Imperial College Genetics and Genomics Research Institute, Hammersmith Hospital, London, UK
    Nature 405:1015-6. 2000
  8. pmc CD36 polymorphism is associated with protection from cerebral malaria
    Kazuya Omi
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Hum Genet 72:364-74. 2003
    The human protein CD36 is a major receptor for Plasmodium falciparum-infected erythrocytes and contributes to the pathology of P. falciparum malaria...
  9. ncbi CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes
    Akihiko Kuniyasu
    Department of Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, 5 1 Ohe Honmachi, Japan
    FEBS Lett 537:85-90. 2003
    ..We here show that AGE-modified bovine serum albumin (BSA) is endocytosed by adipocytes via CD36. Upon differentiation, 3T3-L1 and human subcutaneous adipose cells showed marked increases in endocytic uptake and ..
  10. pmc CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions
    Fabienne Laugerette
    Physiologie de la Nutrition, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation et Centre Européen des Sciences du Goût, UMR 5170 CNRS 1214 INRA Université de Bourgogne, Dijon, France
    J Clin Invest 115:3177-84. 2005
    ..The fatty acid transporter CD36 appears to be a plausible candidate for this function since it has a high affinity for long-chain fatty acids (..
  11. ncbi Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients
    Shizuya Yamashita
    Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Mol Cell Biochem 299:19-22. 2007
    ..Oxidized LDL is taken up by macrophages via scavenger receptors. CD36 is an 88 kDa glycoprotein expressed on platelets, monocyte-macrophages, microvascular endothelial cells, adipose ..
  12. pmc CD36 deficiency leads to choroidal involution via COX2 down-regulation in rodents
    Marianne Houssier
    Institut National de la Santé et de la Recherche Médicale U872, Paris, France
    PLoS Med 5:e39. 2008
    ..The aim of this study is to elucidate the possible implication of the scavenger receptor CD36 in retinal degeneration and choroidal involution, the cardinal features of the dry form of AMD.
  13. pmc Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake
    Jill Smith
    Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:13578-85. 2008
    FAT/CD36 is a membrane scavenger receptor that facilitates long chain fatty acid uptake by muscle. Acute increases in membrane CD36 and fatty acid uptake have been reported in response to insulin and contraction...
  14. pmc Role of human CD36 in bacterial recognition, phagocytosis, and pathogen-induced JNK-mediated signaling
    Irina N Baranova
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:7147-56. 2008
    Scavenger receptor CD36 mediates Staphylococcus aureus phagocytosis and initiates TLR2/6 signaling...
  15. pmc Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans
    Neda Rasouli
    Central Arkansas Veterans Healthcare System, 111J, 4300 West 7th Street, Little Rock, AR 72205, USA
    Arterioscler Thromb Vasc Biol 29:1328-35. 2009
    ..We hypothesized that scavenger receptors are present in human adipose tissue resident macrophages, and their gene expression is regulated by adiponectin and thaizolidinediones...
  16. pmc Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI
    Detao Gao
    Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 285:4447-54. 2010
    Specific oxidized phospholipids (oxPC(CD36)) accumulate in vivo at sites of oxidative stress and serve as high affinity ligands for scavenger receptors class B (CD36 and SR-BI)...
  17. pmc Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase
    Shideh Kazerounian
    Division of Experimental Pathology, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Blood 117:4658-66. 2011
    b>CD36 plays a critical role in the inhibition of angiogenesis through binding to the type 1 repeats of thrombospondin-1 (TSP-1) and activating Fyn tyrosine kinase and MAPK pathways...
  18. pmc Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms
    Arunima Ghosh
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    Blood 117:6355-66. 2011
    b>CD36 modulates platelet function via binding to oxidized LDL (oxLDL), cell-derived microparticles, and thrombospondin-1...
  19. ncbi Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion
    N N Tandon
    Cell Biology Laboratory, American Red Cross, Rockville, Maryland 20855
    J Biol Chem 264:7576-83. 1989
    The role of glycoprotein IV (GPIV) in platelet activation processes has been examined by several different approaches: (i) Fab fragments of a monospecific polyclonal antibody to purified platelet GPIV (approximately 20 micrograms/ml) ..
  20. ncbi CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes
    P Oquendo
    Department of Genetics, Harvard Medical School, Boston, Massachusetts
    Cell 58:95-101. 1989
    ..In apparent reconciliation of these findings, it has been reported that the OKM5 antigen (CD36) is a receptor for thrombospondin...
  21. ncbi CD36 is palmitoylated on both N- and C-terminal cytoplasmic tails
    N Tao
    Department of Pathology, Division of Laboratory Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:22315-20. 1996
    The membrane protein CD36 has been reported to carry out a wide range of potential functions, including serving as a receptor for thrombospondin, collagen, oxidized low density lipoprotein, fatty acids, anionic phospholipids, and ..
  22. ncbi PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    P Tontonoz
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 93:241-52. 1998
    ..monocytic differentiation and promotes uptake of oxLDL through transcriptional induction of the scavenger receptor CD36. These results reveal a novel signaling pathway controlling differentiation and lipid metabolism in monocytic cells,..
  23. ncbi CD36 associates with CD9 and integrins on human blood platelets
    W M Miao
    Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    Blood 97:1689-96. 2001
    The membrane glycoprotein CD36 is involved in platelet aggregation, inhibition of angiogenesis, atherosclerosis, and sequestration of malaria-parasitized erythrocytes...
  24. ncbi A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation
    E Griffin
    Weill Medical College of Cornell University, New York, NY, USA
    Nat Med 7:840-6. 2001
    ..Here we report a glucose-mediated increase in CD36 mRNA translation efficiency that results in increased expression of the macrophage scavenger receptor CD36...
  25. ncbi CD36 deficiency induced by antiretroviral therapy
    Lena Serghides
    Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    AIDS 16:353-8. 2002
    ..The molecular basis of lipodystrophy, a syndrome associated with HIV antiretroviral (ARV) therapy, remains unknown...
  26. pmc Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency
    H Hanawa
    J Med Genet 39:286-91. 2002
  27. ncbi Genomic heterogeneity of type II CD36 deficiency
    Makoto Imai
    Third Division, Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka 569 8686, Japan
    Clin Chim Acta 321:97-106. 2002
    b>CD36 deficiency has been classified in two types, i.e., type I and type II CD36 deficiency. Possible pathological involvement of CD36 deficiency has been suggested in humans, but is still confounding...
  28. ncbi Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    Vidya V Kunjathoor
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:49982-8. 2002
    ..The genetic inactivation of either of two SR family members, SR-A or CD36, has been shown previously to reduce oxidized LDL uptake in vitro and atherosclerotic lesions in mice...
  29. pmc CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum
    Todd G Smith
    Department of Medicine, University of Toronto, Toronto M5S 1A5, Ontario, Canada
    Infect Immun 71:393-400. 2003
    ..Using a number of experimental strategies, we found that the scavenger receptor CD36 mediates the uptake of nonopsonized erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum ..
  30. ncbi Genetic analysis of 22 candidate genes for hypertension in the Japanese population
    Naoharu Iwai
    National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 22:1119-26. 2004
    ..We performed association studies between 118 single-nucleotide polymorphisms (SNPs) of 22 candidate genes (or gene family) and hypertension in a Japanese population...
  31. ncbi A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians
    Xiaowei Ma
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:2197-205. 2004
    b>CD36 is a class B scavenger receptor recognizing a variety of ligands including long-chain fatty acids and modified LDL...
  32. ncbi Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion
    Houtan Noushmehr
    Division Endocrinology and DiabetesMetabolism, Cedars Sinai Medical Center, 8723 Alden Dr, SSB 290, Los Angeles, CA 90048, USA
    Diabetes 54:472-81. 2005
    The membrane receptor FAT/CD36 facilitates the major fraction of long-chain fatty acid (FA) uptake by muscle and adipose tissues...
  33. ncbi Myristic acid stimulates endothelial nitric-oxide synthase in a CD36- and an AMP kinase-dependent manner
    Weifei Zhu
    Department of Pediatrics, University of Kentucky, Lexington, 40536, USA
    J Biol Chem 280:29543-50. 2005
    ..The specific hypothesis tested was that free fatty acid association with CD36, a class B scavenger receptor, induces the activation of endothelial nitric-oxide synthase (eNOS)...
  34. ncbi Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria?
    O K Amodu
    College of Medicine, Institute of Child Health, University of Ibadan, Ibadan, Nigeria
    Acta Trop 95:248-55. 2005
    ..genes coding for four human adhesion molecules at six different loci (ICAM-1 exons 2, 4 and 6, E-selectin exon 2, CD36 exon 10, and PECAM exon 3) were studied...
  35. ncbi Identification of CD36 molecular features required for its in vitro angiostatic activity
    Luca Primo
    Institute for Cancer Research and Treatment, Candiolo, and School of Medicine, University of Torino, Italy
    FASEB J 19:1713-5. 2005
    Thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, acts directly on endothelial cells (EC) via CD36 to inhibit their migration and morphogenesis induced by basic fibroblast growth factor...
  36. pmc Alternative promoter usage of the membrane glycoprotein CD36
    Malin Andersen
    Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology KTH, 106 91 Stockholm, Sweden
    BMC Mol Biol 7:8. 2006
    b>CD36 is a membrane glycoprotein involved in a variety of cellular processes such as lipid transport, immune regulation, hemostasis, adhesion, angiogenesis and atherosclerosis...
  37. ncbi Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting
    Martha Triantafilou
    Infection and Immunity Group, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, United Kingdom
    J Biol Chem 281:31002-11. 2006
    ..attributed to its unique ability to heterodimerize with TLRs 1 and 6 and, most recently, to its association with CD36 in response to diacylated lipoproteins...
  38. ncbi Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance
    E Corpeleijn
    Department of Medicine and Endocrinology, Cardiovascular Research Institute CARIM, University Hospital Maastricht, Maastricht, The Netherlands
    Diabet Med 23:907-11. 2006
    The membrane-bound fatty acid transporter CD36/FAT may play a role in disturbed fatty acid handling as observed in the metabolic syndrome and Type 2 diabetes mellitus (T2DM)...
  39. ncbi Differential roles of CD36, ICAM-1, and P-selectin in Plasmodium falciparum cytoadherence in vivo
    Bryan G Yipp
    Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada
    Microcirculation 14:593-602. 2007
    ..More importantly, the effect of TNF-alpha could be seen only in the presence of CD36. A further increase in adhesion by 4.9-fold was observed after 24 h of TNF-alpha stimulation...
  40. ncbi Soluble CD36 and risk markers of insulin resistance and atherosclerosis are elevated in polycystic ovary syndrome and significantly reduced during pioglitazone treatment
    Dorte Glintborg
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Diabetes Care 31:328-34. 2008
    We investigated the relation between soluble CD36 (sCD36), risk markers of atherosclerosis and body composition, and glucose and lipid metabolism in polycystic ovary syndrome (PCOS).
  41. pmc Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction
    Joshua W Knowles
    Stanford University School of Medicine, Stanford, CA 94305 5405, USA
    Am Heart J 154:1052-8. 2007
    ..Genetic polymorphisms may affect the balance between coagulation and fibrinolysis and thereby affect individual vulnerability to acute myocardial infarction (MI) among patients with underlying coronary atherosclerosis...
  42. pmc Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol
    Latisha Love-Gregory
    Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 17:1695-704. 2008
    ..Within this region, the CD36 gene, which encodes a membrane receptor for long-chain fatty acids and lipoproteins, is a potentially important ..
  43. doi Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes
    Massimo D'Archivio
    National Centre for Food Quality and Risk Assessment, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    FEBS Lett 582:2291-8. 2008
    The effect of oxLDL on CD36 expression has been assessed in preadipocytes induced to differentiate...
  44. pmc The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure
    Michael M Klein
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS Pathog 4:e1000147. 2008
    ..Almost all parasites isolated directly from patients bind the human CD36 receptor...
  45. doi CD36 gene promoter polymorphisms are associated with low density lipoprotein-cholesterol in normal twins and after a low-calorie diet in obese subjects
    Estibaliz Goyenechea
    Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Spain
    Twin Res Hum Genet 11:621-8. 2008
    Common polymorphisms of the CD36 fatty acid transporter gene have been associated with lipid metabolism and cardiovascular disease...
  46. pmc CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima
    Young Mi Park
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Clin Invest 119:136-45. 2009
    ..However, the mechanism by which this occurs is not clearly defined. Here, we tested in mice the hypothesis that CD36, a class B scavenger receptor expressed on macrophages, has a role in this process...
  47. doi Role of PPAR-gamma in the modulation of CD36 and FcgammaRII induced by LDL with low and high degrees of oxidation during the differentiation of the monocytic THP-1 cell line
    Francisco J O Rios
    Laboratórios de Imunofisiopatologia e Imunofarmacologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Brazil
    Cell Physiol Biochem 22:549-56. 2008
    ..The levels of scavenger receptor CD36 are increased in atherosclerotic lesions and there is evidence that some components of oxLDL auto-regulate the ..
  48. pmc Cellular fatty acid uptake: a pathway under construction
    Xiong Su
    Department of Medicine, Center for Human Nutrition, Washington University, St Louis, MO 63110, USA
    Trends Endocrinol Metab 20:72-7. 2009
    ..b>CD36 facilitates a major fraction of FA uptake by key tissues...
  49. pmc Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms
    Bupe R Mwaikambo
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 284:26695-707. 2009
    ..Hypoxia or reduced oxygen tension is considered central to the pathogenesis of these disorders. Although the CD36 scavenger receptor features prominently in ocular homeostasis and pathology, little is known regarding its ..
  50. pmc CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    Cameron R Stewart
    Lipid Metabolism Unit, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:155-61. 2010
    ..Assembly of this newly identified heterodimer is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands...
  51. doi Soluble CD36 (sCD36) clusters with markers of insulin resistance, and high sCD36 is associated with increased type 2 diabetes risk
    A Handberg
    Department of Clinical Biochemistry, Aarhus University Hospital, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 95:1939-46. 2010
    Soluble CD36 (sCD36) may be an early marker of insulin resistance and atherosclerosis...
  52. doi Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade
    Wayne Roberts
    Hull York Medical School, University of Hull, Castle Hill Hospital, Cottingham, UK
    Blood 116:4297-306. 2010
    ..Here we show that thrombospondin-1 (TSP-1) prevents cAMP/protein kinase A (PKA) signaling through a CD36-dependent mechanism...
  53. pmc Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile
    Latisha Love-Gregory
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 20:193-201. 2011
    Membrane CD36 functions in the uptake of fatty acids (FAs), oxidized lipoproteins and in signal transduction after binding these ligands. In rodents, CD36 is implicated in abnormal lipid metabolism, inflammation and atherosclerosis...
  54. doi Soluble CD36- a marker of the (pathophysiological) role of CD36 in the metabolic syndrome?
    Debby P Y Koonen
    Molecular Genetics, Department of Pathology and Medical Biology, University Medical Center Groningen, The Netherlands
    Arch Physiol Biochem 117:57-63. 2011
    b>CD36 is a class B scavenger receptor observed in many cell types and tissues throughout the body...
  55. doi Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C
    María Eugenia Miquilena-Colina
    Liver Research Unit, University Hospital Santa Cristina, Instituto de Investigación Sanitaria Princesa, Madrid, Spain
    Gut 60:1394-402. 2011
    b>Fatty acid translocase CD36 (FAT/CD36) mediates uptake and intracellular transport of long-chain fatty acids in diverse cell types...
  56. pmc Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome
    Lucy B Ochola
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Kilifi, Kenya
    PLoS ONE 6:e14741. 2011
    ..this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype...
  57. pmc Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function
    Khuloud Jaqaman
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 146:593-606. 2011
    ..We used single-molecule tracking to investigate the dynamics of CD36, a clustering-responsive receptor that mediates oxidized LDL uptake by macrophages...
  58. pmc Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age
    Monika Ewa Rać
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111, Szczecin, Poland
    Biochem Genet 50:103-11. 2012
    This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age...
  59. pmc The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes
    Barbara Renga
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Perugia, Italy
    PLoS ONE 7:e35924. 2012
    ..A sustained immune activation supports lipid dysmetabolism and increased risk for development of accelerated atehrosclerosis and ischemic complication in virologically suppressed HIV-infected persons receiving HAART...
  60. doi Functional consequences of CD36 downregulation by TLR signals
    Carlos Zamora
    Department of Immunology, Institut Recerca Hospital S Pau, Barcelona, Spain
    Cytokine 60:257-65. 2012
    ..mononuclear cells (PBMC) with TLR2 (Pam3CSK4 and FSL1) and TLR4 ligand lipopolysaccharide (LPS) and then analyzed CD36 expression on different monocyte subpopulations by flow cytometry...
  61. ncbi CD36 gene is associated with thickness of atheromatous plaque and ankle-brachial index in patients with early coronary artery disease
    Monika Ewa Rać
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Kardiol Pol 70:918-23. 2012
    b>CD36 is a multifunctional molecule engaged in the removal of oxidised LDL from plasma. It is unclear whether mutation of the CD36 gene protects against, or increases, the risk of hypercholesterolaemia, atherosclerosis and its complications...
  62. ncbi FIP2 and Rip11 specify Rab11a-mediated cellular distribution of GLUT4 and FAT/CD36 in H9c2-hIR cells
    Robert W Schwenk
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Auf m Hennekamp 65, D 40225 Dusseldorf, Germany
    Biochem Biophys Res Commun 363:119-25. 2007
    ..two of its effectors, Rip11 and FIP2, in H9c2-hIR cells and measured the cell surface abundance of GLUT4myc and FAT/CD36. We observed that by knocking down Rab11a, both GLUT4myc and FAT/CD36 abundance at the plasma membrane were ..
  63. pmc The C-terminal segment of the cysteine-rich interdomain of Plasmodium falciparum erythrocyte membrane protein 1 determines CD36 binding and elicits antibodies that inhibit adhesion of parasite-infected erythrocytes
    Min Mo
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551
    Infect Immun 76:1837-47. 2008
    ..The interaction between CIDRalpha and CD36 promotes stable adherence of parasitized erythrocytes to endothelial cells...
  64. ncbi CD36 genotype and long-chain fatty acid uptake in the heart
    Taigo Kintaka
    Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan
    Circ J 66:819-25. 2002
    Homozygous or compound heterozygous mutation of the CD36 gene (CD36-/-) in humans results in severe defects of the uptake of long-chain fatty acids (LCFAs) in the heart...
  65. pmc CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria
    Laura K Erdman
    McLaughlin Rotman Centre for Global Health, McLaughlin Centre for Molecular Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Immunol 183:6452-9. 2009
    b>CD36 participates in macrophage internalization of a variety of particles, and has been implicated in inflammatory responses to many of these ligands...
  66. ncbi Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands
    Osamu Sato
    Department of Biochemistry, School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274 8510 Japan
    J Biol Chem 277:15703-11. 2002
    b>Fatty acid translocase (FAT)/CD36 is a glycoprotein involved in multiple membrane functions including uptake of long-chain fatty acids and oxidized low density lipoprotein...
  67. pmc Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes
    Andrew E Fry
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
    Hum Mol Genet 18:2683-92. 2009
    The prevalence of CD36 deficiency in East Asian and African populations suggests that the causal variants are under selection by severe malaria...
  68. pmc Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake
    Jeff S Isenberg
    Laboratory of Pathology and Radiation Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:15404-15. 2007
    ..cell nitric oxide signaling in a CD36-dependent manner, we examined the ability of TSP1 to modulate the fatty acid translocase activity of CD36. TSP1 and a CD36 antibody that mimics the activity of TSP1 inhibited myristate uptake...
  69. pmc The association of CD36 variants with polypoidal choroidal vasculopathy compared to typical neovascular age-related macular degeneration
    Hiroaki Bessho
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    Mol Vis 18:121-7. 2012
    To clarify the association of cluster of differentiation 36 (CD36) variants with polypoidal choroidal vasculopathy (PCV) and compare them with those in typical neovascular age-related macular degeneration (tAMD).
  70. ncbi CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease
    D Teupser
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Clin Exp Pharmacol Physiol 35:552-6. 2008
    ..scavenger receptor class B member 1 (SRB1), lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1), CD36, LDL receptor (LDLR)), reverse cholesterol transport (apolipoprotein E (ApoE), ATP-binding cassette sub-family A ..
  71. ncbi Association of the Pro90Ser CD36 mutation with elevated free fatty acid concentrations but not with insulin resistance syndrome in Japanese
    S Kajihara
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Clin Chim Acta 314:125-30. 2001
    b>CD36 deficiency is reportedly an underlying factor about insulin resistance, defective fatty acid metabolism and hypertriglyceridemia in spontaneously hypertensive rat (SHR), and may be involved in the pathogenesis of insulin resistance ..
  72. ncbi Identification of a serum component that regulates cyclooxygenase-2 gene expression in cooperation with 4-hydroxy-2-nonenal
    Masaya Kanayama
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 282:24166-74. 2007
    ..induction is regulated by two sets of signaling mechanisms, one for the up-regulation of the scavenger receptor CD36 by HNE and one for the CD36-mediated COX induction by oxidized LDL...
  73. ncbi Increased expression of a scavenger receptor (CD36) in monocytes from subjects with Type 2 diabetes
    Michael J Sampson
    Bertram Diabetes Research Unit, Department of Endocrinology and Diabetes, Norfolk and Norwich University Hospital NHS Trust, UK
    Atherosclerosis 167:129-34. 2003
    Uptake of modified low density lipoprotein (LDL) by monocyte-macrophages is mediated by the scavenger receptor CD36, which is upregulated in vitro by high glucose concentrations and oxidatively modified LDL...
  74. pmc Expression of both N- and C-terminal GFP tagged huCD36 and their discrepancy in OxLDL and pRBC binding on CHO cells
    Jianshe Zhang
    Department of Bioengineering and Environmental Science, Changsha University, Changsha, Hunan, China
    Lipids Health Dis 6:24. 2007
    b>CD36, an 88 kDa membrane glycoprotein, is found in several cell types and it has been characterized to have two hydrophobic domains at their N- and C-termini which are essential for protein folding and targeting...
  75. ncbi Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2
    E Fernandez-Ruiz
    Departamento de Immunologia, Hospital de la Princesa, Madrid, Spain
    Genomics 17:759-61. 1993
    The human CD36 is a member of a gene family of structurally related glycoproteins and functions as a receptor for collagen type I and thrombospondin...
  76. ncbi Structural organization of the gene for human CD36 glycoprotein
    A L Armesilla
    Hospital de la Princesa, Madrid, Spain
    J Biol Chem 269:18985-91. 1994
    The cell-surface glycoprotein CD36 interacts with a large variety of ligands, including collagen types I and IV, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, platelet-agglutinating protein p37, oxidized low density ..
  77. pmc Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency
    H Kashiwagi
    Second Department of Internal Medicine, Osaka University Medical School, Japan
    J Clin Invest 95:1040-6. 1995
    b>CD36 deficiency is divided into two subgroups: neither platelets nor monocytes express CD36 (type I deficiency), and monocytes express CD36 in spite of the lack of platelet CD36 (type II deficiency)...
  78. ncbi Genetic study of the CD36 gene in a French diabetic population
    F Lepretre
    Institute of Biology CNRS 8090, Pasteur Institute of Lille, France
    Diabetes Metab 30:459-63. 2004
    b>CD36 is a multifunctional membrane receptor widely expressed in different tissues which binds and internalizes oxidized low-density lipoprotein...
  79. pmc Molecular basis of human CD36 gene mutations
    Monika Ewa Rać
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Mol Med 13:288-96. 2007
    b>CD36 is a transmembrane glycoprotein of the class B scavenger receptor family. The CD36 gene is located on chromosome 7 q11.2 and is encoded by 15 exons...
  80. doi Variants in the CD36 gene locus determine whole-body adiposity, but have no independent effect on insulin sensitivity
    Martin Heni
    Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tubingen, Member of the German Center for Diabetes Research DZD, Tubingen, Germany
    Obesity (Silver Spring) 19:1004-9. 2011
    b>CD36 variants have been associated with type 2 diabetes, features of the metabolic syndrome, and alterations in lipid metabolism...
  81. ncbi A non-sense mutation in Cd36 gene is associated with protection from severe malaria
    A Pain
    Lancet 357:1502-3. 2001
    We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria...
  82. doi Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis
    Lars P Bechmann
    Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
    Liver Int 30:850-9. 2010
    ..We studied the effect of obesity on free fatty acid (FFA) levels, fatty acid transport proteins (FATPs) and on extrinsic and intrinsic activation of apoptosis in the liver...
  83. ncbi Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
    D Calvo
    Hospital de la Princesa, Madrid, Spain
    J Lipid Res 39:777-88. 1998
    ..b>CD36, a multigland glycoprotein structurally related to SR-BI and CLA-1, has been reported to bind oxidized low density ..
  84. pmc The terminal six amino-acids of the carboxy cytoplasmic tail of CD36 contain a functional domain implicated in the binding and capture of oxidized low-density lipoprotein
    Eric Malaud
    INSERM U331, Faculty of Medecine RTH Laënnec, 8 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Biochem J 364:507-15. 2002
    b>CD36, a major adhesion molecule expressed by monocytes/macrophages, plays a key role in the binding and internalization of oxidized low-density lipoprotein (OxLDL)...
  85. ncbi Endocytosis of oxidized low density lipoprotein through scavenger receptor CD36 utilizes a lipid raft pathway that does not require caveolin-1
    Youchun Zeng
    Department of Pathology, Division of Laboratory Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:45931-6. 2003
    The scavenger receptor CD36 binds a diverse array of ligands, including thrombospondin-1, oxidized low density lipoprotein (OxLDL), fatty acids, anionic phospholipids, and apoptotic cells...
  86. pmc Attenuated aerobic exercise capacity in CD36 deficiency
    Hidekatsu Yanai
    Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo 060 8648, Japan
    J Med Genet 44:445-7. 2007
    An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT)...
  87. pmc Positive association of common variants in CD36 with neovascular age-related macular degeneration
    Naoshi Kondo
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Aging (Albany NY) 1:266-74. 2009
    ..Oxidative stress is a hypothesized pathway for the pathophysiology of AMD. CD36 was chosen as a candidate gene for neovascular AMD because the protein plays an important role in this pathway as ..
  88. doi Analysis of human CD36 gene sequence alterations in the oxidized low-density lipoprotein-binding region using denaturing high-performance liquid chromatography
    Monika Ewa Rać
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland
    Genet Test Mol Biomarkers 14:551-7. 2010
    ..could be a simple and cost-effective screening method for mutations and polymorphisms in exons 4, 5, and 6 of the CD36 gene, which encode the protein region responsible for the removal of oxidized low-density lipoprotein...
  89. ncbi Increased CD36 expression on circulating monocytes during HIV infection
    Luca Meroni
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    J Acquir Immune Defic Syndr 38:310-3. 2005
    ..b>CD36 is a multifunctional receptor with a wide tissue distribution that plays a crucial role in the cellular uptake and ..
  90. ncbi Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance
    Aase Handberg
    Department of Clinical Biochemistry, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark
    Circulation 114:1169-76. 2006
    Macrophage CD36 scavenges oxidized low-density lipoprotein, leading to foam cell formation, and appears to be a key proatherogenic molecule...
  91. ncbi Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types
    K T Taylor
    Cell Biology Department, Jerome H Holland Laboratory, American Red Cross, Rockville, MD 20855
    Gene 133:205-12. 1993
    ..6-kb BamHI-EcoRI fragment from the 5'-end of the human gene encoding the cell adhesion receptor, CD36. This region contains the first coding exon, exon 3, as well as two non-coding exons, exons 2a and 2b, from the 5'-..
  92. ncbi A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes
    Frederic Lepretre
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mutat 24:104. 2004
    Mutations in CD36 / fatty acid translocase (FAT) gene are responsible for insulin resistance in the rat but contribution to human Type 2 diabetes is unknown...
  93. ncbi Expression of thrombospondin receptor (CD36) in B-cell chronic lymphocytic leukemia as an indicator of tumor cell dissemination
    S Rutella
    Department of Hematology, Center for the Flow Cytometric Study of Blood Cells, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
    Haematologica 84:419-24. 1999
    The expression of CD36 antigen has not been conclusively associated with human B-lymphocytes although CD36 was recently detected in a human B-cell angiotropic lymphoma where it might be involved in lymphoblast-endothelial cell adhesion...
  94. ncbi The OB protein (leptin) pathway--a link between adipose tissue mass and central neural networks
    L A Campfield
    Department of Metabolic Diseases, Hoffmann-La Roche Inc, Nutley, NJ 07110, USA
    Horm Metab Res 28:619-32. 1996
    ..OB protein provides a communication link from fat tissue and the brain...
  95. ncbi Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features
    W Demark-Wahnefried
    Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Urology 58:47-52. 2001
    OBJECTIVES: Dietary fat and fiber affect hormonal levels and may influence cancer progression. Flaxseed is a rich source of lignan and omega-3 fatty acids and may thwart prostate cancer...
  96. ncbi Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at adipocytes
    G Muller
    Hoechst AG Frankfurt, Germany
    Horm Metab Res 28:469-87. 1996
    ..tissues would imply a similar ranking between the two drugs in glucose utilizing processes in isolated muscle and fat cells...
  97. ncbi Diet, antioxidant vitamins, oxidative stress and risk of coronary artery disease: the Peerzada Prospective Study
    R B Singh
    Centre of Nutrition Research, Medical Hospital and Research Centre, Moradabad, Varanasi College for Women Trivandrum, India
    Acta Cardiol 49:453-67. 1994
    ..Compared with British population, the Indian urbans consumed less total and saturated fat and cholesterol and more polyunsaturated fat and complex carbohydrates...
  98. ncbi Lipoprotein lipase activity and its relationship to high milk fat transfer during lactation in grey seals
    S J Iverson
    Canadian Institute of Fisheries Technology, Technical University of Nova Scotia, Halifax, Canada
    J Comp Physiol B 165:384-95. 1995
    ..is critical for the uptake and secretion of the long-chain fatty acids in milk and for the assimilation of a high-fat milk diet by suckling young...
  99. ncbi The role of diet history and biologic assays in the study of "diet and breast cancer"
    M Gerber
    INSERM Centre Paul Lamarque, Montpellier, France
    Tumori 76:321-30. 1990
    ..A significant difference was found between cases and controls in total fat and cholesterol intake in both populations, and in saturated fatty acid and mono-unsaturated fatty acid consumption ..
  100. ncbi Prolonged oral glucose tolerance test combined with indirect calorimetry and estimation of several substrates and hormones in obese subjects
    J Sonka
    Laboratory for Endocrinology and Metabolism, Ist Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 39:39-47. 1993
    ..The correlations brought additional information. Insulinemia increased parallel with the amount of body fat. The basal level was decisive for most hormones and substrates--the high or low set level could be followed in the ..
  101. ncbi The impact of dietary fats, photoperiod, temperature and season on morphological variables, torpor patterns, and brown adipose tissue fatty acid composition of hamsters, Phodopus sungorus
    F Geiser
    , Marburg, Germany
    J Comp Physiol B 165:406-15. 1995
    ..oil (rich in monounsaturated fatty acids) and least pronounced in individuals on a diet containing 10% coconut fat (rich in saturated fatty acids). Torpor in P...

Research Grants139 found, 100 shown here

  1. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
    ..Strikingly, our FKBP52 heterozygous mice, when fed a high fat diet, acquire symptoms similar to the Metabolic Syndrome;in which they develop hyperglycemia, hyperlipidemia, ..
  2. Endoplasmic Reticulum Chaperone as a Regulator of Obesity and Diabetes
    Amy S Lee; Fiscal Year: 2010
    ..Serendipitously, we discovered that the Grp78 mice in the C57BL/6 background exhibit resistance to high-fat diet (HFD)-induced obesity and improved insulin sensitivity...
  3. NKT cells, fatty acids, and insulin resistance
    CURTIS LEE GABRIEL; Fiscal Year: 2010
    ..To achieve this goal, we will feed mice a lard diet, a fish oil diet or a low-fat diet, and will analyze NKT cells using flow cytometry, ELISA and ex vivo stimulation assays...
  4. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
    ..indicate that other measures of body composition, including lean muscle and intermuscular, liver and pericardial fat, are correlated with adipocytokines and atherosclerotic cardiovascular disease (CVD)...
  5. Effects of resistant starch on lipid and glucose metabolism in insulin resistance
    RONALD M contact KRAUSS; Fiscal Year: 2010
    ..Current dietary guidelines emphasize substitution of carbohydrate calories for total and saturated fat calories for prevention and management of chronic disease...
  6. Effect of Perinatal Diet on Developmental Programming of the Skeleton
    Mary L Bouxsein; Fiscal Year: 2010
    ..Perinatal diet is of particular interest because maternal caloric restriction (CR) and high fat (HF) diet have each been shown to trigger developmental programming that increases the risk of metabolic disease, ..
  7. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..Furthermore, changes in body fat observed in obesity, or changes in body mass index (as observed in patients suffering from functional ..
  8. SH2-B regulation of body weight and energy homeostasis
    Liangyou Rui; Fiscal Year: 2010
    ..Leptin, which is produced by adipose tissue and secreted into the bloodstream in proportion to the total fat mass, binds to and activates its receptor in the hypothalamus, relaying peripheral nutritional signals to the ..
  9. PD2024: A Peripherally Active TNFalpha inhibitor for the treatment of Obesity
    SOMASUNDAR PRASAD GABBITA; Fiscal Year: 2010
    ..of our lead TNF1 inhibitor on food intake, body weight, energy expenditure, circadian activity, and total body fat/lean body mass in high-fat diet-induced obese rats and lean rats fed standard low-fat lab chow...
  10. Metabolic Consequences of Neonatal Programming by a GLP1 Receptor Agonist
    DANIELLA ANGELA BABU; Fiscal Year: 2011
    ..Further, our preliminary data demonstrate that the effect of neonatal Ex-4 on body weight and fat mass is conserved in C57BI6 mice...
  11. Effects of Recombinant IGF-I in HIV Associated Metabolic Disease
    Roy J Kim; Fiscal Year: 2011
    ..the use of these medications is associated with development of a syndrome consisting of abnormal changes in fat distribution, dyslipidemia, and abnormal glucose homeostasis...
  12. Role of the transcriptional coregulator, TRIP Br2, in adipocyte metabolism
    Chong Wee Liew; Fiscal Year: 2011
    ..These studies will determine the mechanisms contributing to high fat diet-induced obesity resistance in our mouse model...
  13. Quantification of Brown Adipose Tissue by MRI in Children and Teenagers
    Vicente Gilsanz; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The objective of this proposal is to develop and validate chemical-shift fat-water MRI methods for the detection and quantification of both metabolically active and inactive brown adipose tissue (BAT)..
  14. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..SCD1 has been shown to increase the synthesis and secretion of triglycerides following a high-saturated fat or high-carbohydrate diet...
  15. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..Second, PDK knock out mice maintained on a high-fat, diabetogenic diet accumulate less fat in their livers, are less obese, and have lower blood glucose levels, better ..
  16. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..of obesity) or WHR (as a measure of abdominal obesity) will be further tested for association with total body fat by DEXA scan (as a confirmatory measure of global obesity) and the ratio of visceral fat / subcutaneous fat by CT ..
  17. Ashraf Gorgey; Fiscal Year: 2016
    ..Within few weeks of injury, there are significant decrease in whole body fat-free mass (FFM), particularly lower extremity skeletal muscle mass and subsequent increase in fat mass (FM)...
  18. METABOLICALLY NORMAL AND ABNORMAL OBESITY
    Samuel Klein; Fiscal Year: 2012
    ..It is not known why weight gain and body fat accumulation causes metabolic abnormalities in some obese persons but not in others...
  19. Noninvasive Measurement of UCP1 in Brown Adipose Tissue
    Joel K Yisraeli; Fiscal Year: 2012
    ..There are at least two clearly distinguishable forms of fat: white adipose tissue (WAT), which stores energy, and brown adipose tissue (BAT), which burns energy for ..
  20. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
    ..to its receptor TrkB;2) BDNF effects on energy balance are mediated by CRHR signaling pathway;3) BDNF prevents high fat diet (HFD) induced obesity;and 4) Chronic BDNF induces proliferation of newborn neurons that impact energy ..
  21. BMP7 and the regulation of central and peripheral energy balance
    Kristy Townsend; Fiscal Year: 2012
    ..Thus far, we have found that mice with BMP7 haploinsufficiency (BMP7-/+) on a high fat diet (HFD) are more obese and hyperphagic than littermate controls, with decreased energy expenditure (oxygen ..
  22. AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
    Clinton T Rubin; Fiscal Year: 2012
    ..In an unexpected finding, these signals also suppress adipogenesis, with 29% less total visceral abdominal fat in mice subject to 12w of LMMS...
  23. Mechanisms by which the protein kinase IKKi regulates energy expenditure
    JONATHAN CARL MOWERS; Fiscal Year: 2012
    ..IKKi expression and activity are dramatically increased in mice on a high fat diet in both liver and white adipose tissue...
  24. Remodeling of Lipid Metabolism by Dietary Methionine Restriction
    ERIC PAUL PLAISANCE; Fiscal Year: 2012
    ..characterized by a cluster of pathologies that includes obesity and impaired regulation of carbohydrate and fat metabolism...
  25. Susan S Smyth; Fiscal Year: 2014
    ..at promoting energy expenditure by increasing brown adipose tissue (BAT) content or activity in adults could reduce fat deposition and obesity...
  26. Is HIV-associated lipodystrophy a risk factor for cirrhosis of the liver?
    George Ioannou; Fiscal Year: 2013
    ..Insulin resistance and increased intra-abdominal fat are also the major predisposing conditions of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic ..
  27. Regulation of energy homeostasis and adiposity by a Golgi-associated PARP enzyme
    Nai Wen Chi; Fiscal Year: 2013
    ..owing to increased energy expenditure, are protected from obesity and lipotoxicity when challenged with a high fat diet. Aim 3 will investigate the adipose-specific roles of TNKS in adiponectin secretion and energy homeostasis...
  28. Nicotinamide N-methyltransferase (NNMT) in obesity and insulin resistance
    Qin Yang; Fiscal Year: 2013
    ..Knockdown of NNMT with antisense oligonucleotides (ASO) in adipose tissue and liver of mice fed a high fat diet induces expression of spermine/spermidine acetyltransferase (SSAT), a key enzyme regulating polyamine flux in ..
  29. Effects of gastric bypass on the gut microbiota and energy balance
    Alice Liou; Fiscal Year: 2012
    ..are heavily influenced by diet and have recently been implicated as powerful regulators of obesity-associated fat deposition, decreased energy expenditure, and insulin resistance...
  30. Scott B Going; Fiscal Year: 2016
    ..The proposed project is designed to clarify the relationship of obesity, fat distribution (visceral adipose tissue and tigh muscle fat content), insulin resistance (HOMA-IR) and inflammation (..
  31. David E Harrison; Fiscal Year: 2014
    ..The following will be determined: body composition and subcutaneous/visceral fat tissue distribution (using computerized tomography imaging);circulating adipokines (adiponectin, resistin, IL-6, ..
  32. Genetic Determinants of Visceral Adiposity
    Yongmei Liu; Fiscal Year: 2013
    ..the proposed study provides a unique opportunity to discover genes (and their variants) involved in visceral fat accumulation and may provide novel insights into the pathophysiology, prevention and promising therapeutic targets ..
  33. Andrew B Muir; Fiscal Year: 2014
    ..Studies, mainly in rodents show that maternal ingestion of a high fat, high sugar, high calorie diet (HCD) during pregnancy and lactation programs behaviors and metabolism that promote ..
  34. Jianhua Shao; Fiscal Year: 2016
    ..By using high fat diet-induced obese dams and adiponectin knockout mice, Specific Aim 3 will study the effects of maternal obesity ..
  35. David G Harrison; Fiscal Year: 2015
    ..vascular ROS production develop exaggerated obesity and insulin resistance/metabolic syndrome when fed high-fat diet. Scavenging of ROS attenuated weight gain in these mice...
  36. Huaizhu Wu; Fiscal Year: 2016
    ..Our preliminary data show that: (1) obesity with insulin resistance induced by high-fat (HF) diet rich in saturated FAs up-regulates CD11c on blood monocytes and AT macrophages;(2) CD11c contributes to ..
  37. The Impact of Heat Shock Protein Expression on Inflammation and Insulin Action
    Andrea L Hevener; Fiscal Year: 2013
    ..genetic overexpression of HSP72 will protect against inflammation, insulin resistance, and obesity induced by high fat diet (HFD) or leptin deficiency...
  38. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..Likewise, whether vitamin D level influences fat, muscle, and bone mass in individuals undergoing weight loss through diet and exercise is unclear...
  39. David A Bernlohr; Fiscal Year: 2016
    ..When placed on high fat diets, FABP knockout mice exhibit attenuated characteristics of the metabolic syndrome including diminished ..
  40. LINDA ANNE BARBOUR; Fiscal Year: 2014
    ..Although frank hyperglycemia from gestational diabetes (GDM) is recognized as a major fuel source affecting fetal fat accretion, the alarming increase in the number of large for gestational age (LGA) infants are being born primarily ..
  41. HEIKE MUENZBERG-GRUENING; Fiscal Year: 2016
    ..g. muscle and white fat) are investigated for leptin induced changes (e.g fat oxidation, mitogenesis)...
  42. Amy Johnson; Fiscal Year: 2015
    ..immune system infiltrate adipose tissue at the onset of weight gain contributing to the inflammatory state of fat, ultimately resulting in systemic insulin resistance, while alternatively activated, anti-inflammatory M2 ..
  43. Keiko Watanabe; Fiscal Year: 2015
    ..rats, we demonstrated that periodontitis accelerates the development of insulin resistance (IR) and T2DM in high fat (HF), but not low fat fed animals...
  44. Stefan A Czerwinski; Fiscal Year: 2014
    ..Recent studies have demonstrated potential mechanistic links between visceral fat accumulation and increased deposition of fat in the liver...
  45. Bette J Caan; Fiscal Year: 2016
    ..Though overweight persons tend to have both higher amounts of lean and fat mass, low levels of muscle mass may be present in overweight or obese people;sarcopenia (muscle wasting) is common ..
  46. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..subjects and did not measure effects on adipocyte lipolysis, adipokine secretion, lipogenesis or visceral fat. We hypothesize that EPA/DHA supplementation will not only reduce plasma TG, but also decrease systemic and tissue ..
  47. Maternal Overweight: Consequences for Insulin Signaling in the Offspring
    Kartik Shankar; Fiscal Year: 2013
    ..objective is to investigate interactions in the offspring, between an obesegenic environment (consumption of a high-fat diet, HFD) and prior exposure to maternal OW during gestation...
  48. GUANG WILLIAM WONG; Fiscal Year: 2016
    ..Transgenic (Tg) mice with elevated circulating CTRP9 are significantly leaner due to reduced fat mass...
  49. Oleg Varlamov; Fiscal Year: 2014
    ..Studies in prostate cancer patients also demonstrated that intensive lifestyle changes, including a low-fat diet (LFD), can slow the progression of prostate cancer, but the benefits of a diet restriction for reducing MS and ..
  50. The Role of H6PDH and 11beta-HSD1 in Type 2 Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2013
    ..hepatic and adipose 112-HSD1 activity that may contribution to insulin sensitivity and weight loss in a high- fat diet model of obesity...
  51. Pamela U Freda; Fiscal Year: 2014
    ..ongoing prospective acromegaly cohort study to characterize novel features of acromegaly including an abnormal fat distribution that may contribute significantly to its increased morbidity and mortality...
  52. Muscle, Fat and NK Lymphocytes in Aging
    Charles T Lutz; Fiscal Year: 2013
    ..Skeletal muscle and fat are known to regulate each other via cytokines, including adipose-derived tumor necrosis factor (TNF) and IL-6, ..
  53. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..If visceral fat is a key factor that increases risk in obese older adults, do weight reducing diets that decrease total fat mass as ..
  54. Anna Eisenstein; Fiscal Year: 2015
    ..Furthermore, administration of a high fat, high cholesterol diet (HFD) vastly upregulates the expression of the A2b adenosine receptor (A2bAR), and A2bAR KO ..
  55. Effects of amino acids on regional lipid metabolism
    Elisabet Borsheim; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Elevated fat level in blood is a risk factor for coronary heart disease, a major cause of death in America...
  56. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
    ..While the close relationship between obesity and diabetes has long been recognized, understanding how an expanded fat mass results in the progressive development of insulin resistance and type 2 diabetes has proven difficult...
  57. Ajay Chawla; Fiscal Year: 2016
    ..Moreover, the recent discovery of brown adipose tissue in humans suggests that activation of brown fat might be useful in the treatment of human obesity...
  58. ALEXANDER BANKS; Fiscal Year: 2014
    ..Phosphorylation of PPAR-gamma at serine 273 occurs shortly after the onset of high fat diet feeding and increases with progressive obesity...
  59. TYPE 2 DIABETES IN HISPANIC ADOLESCENTS
    MICHAEL ISAAC GORAN; Fiscal Year: 2013
    ..several years, and this was associated with a 32% lower beta-cell function, and an accelerated gain in visceral fat over time...
  60. Kerri M Winters-Stone; Fiscal Year: 2014
    ..that active participation in whole-body vibration (WBV) training will result in suppression of accumulation of fat, maintenance of lean muscle mass and reduced levels of risk factors as- sociated with obesity...
  61. JOSHUA ROBERT COOK; Fiscal Year: 2015
    ..I will therefore perform the temperature exposure experiments again following high- fat feeding of A-FoxO1 and WT mice and determine whether A-FoxO1 mice differ significantly in their sensitivity to ..
  62. Sihem Boudina; Fiscal Year: 2016
    ..The adipocyte- specific MnSOD KO (AdSod2KO) mice are lean, have increased whole body fat oxidation and resist diet-induced glucose intolerance, insulin resistance and hepatic steatosis...
  63. IL-15, Body Compositition and Insulin Sensivity in Aging
    LeBris S Quinn; Fiscal Year: 2010
    ..muscle mass (termed sarcopenia), as well as by increases in white adipose tissue mass, resulting in an increased fat:lean body composition ratio...
  64. The AMP-activated protein kinase (AMPK) antagonizes inflammation through SIRT1
    Hang Shi; Fiscal Year: 2012
    ..macrophages, and will characterize the inflammatory status and insulin sensitivity in these mice fed a high-fat diet or infused with lipids...
  65. TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic Disorders
    Andrew S Greenberg; Fiscal Year: 2010
    ..Preliminary Studies demonstrate that relative to wild-type (WT) mice, TPL2 knockout (TPLKO) mice fed a high fat diet (HFD) were substantially protected from 1) macrophage-mediated adipose tissue inflammation, 2) adipose and ..
  66. Beta-adrenergic regulation of adipose tissue function by PKA and MAP kinases
    Sheila Collins; Fiscal Year: 2009
    ..metabolism to control (i) lipolysis for mobilization of stored energy and (ii) adaptive thermogenesis in brown fat. All 3 known [unreadable]AR subtypes are expressed in adipocytes, and [unreadable]ARs are coupled to increases in ..
  67. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..include global cell proliferation (mammary, prostate, skin, liver, lymphocytes), adipose tissue dynamics and fat distribution, insulin sensitivity, and vascular smooth muscle cell proliferation...
  68. T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced Obesity
    CHRISTIE MITCHELL BALLANTYNE; Fiscal Year: 2013
    ..Using a mouse model of obesity induced by a high-fat (HF) diet rich in saturated fatty acids (SFAs), we made the novel finding that T cells are increased and the ..
  69. Functional Analysis of MGAT Enzymes
    Robert V Farese; Fiscal Year: 2010
    ..thought to be important in many essential biological processes in metazoans, including the absorption of dietary fat, the preservation of unsaturated (and essential) fatty acids in tissues, and the assembly and secretion of TG-rich ..
  70. Peter D Reaven; Fiscal Year: 2015
    ..rapid rise in these conditions over the past several decades is related to increases in the caloric load and high fat content of typical diets...
  71. Sogol Mostoufi-Moab; Fiscal Year: 2016
    ..Despite completion of therapy years prior, these recipients had markedly increased whole body fat mass, decreased lean mass, and substantial deficits in trabecular BMD and cortical dimensions compared with >650 ..
  72. LAUREN ASHLEY COWART; Fiscal Year: 2016
    ..Moreover, we found that ablation of SK1 attenuated high-fat diet-induced immune cell infiltrate in adipose tissue...
  73. Vince N Montes; Fiscal Year: 2014
    ..lesion development when placed on a diet that resembles the typical Western diet that is high in saturated fat and cholesterol...
  74. The Role of Visceral Fatty Acids in Relation to Insulin Resistance
    Michelle T Foster; Fiscal Year: 2013
    ..by applicant): Project Summary / Abstract Chronic exposure of the liver to elevated FAs, as occurs on a high-fat diet (HFD), promotes liver gluconeogenesis, reduces enzymes of FA oxidation and increases hepatic lipogenesis, ..
  75. SUNEIL KRISHNA KOLIWAD; Fiscal Year: 2014
    ..Emerging data support the concept that this response is instigated by lipids released from, for example, fat or liver cells, that are taken up by resident MCs, modulating their function to incite an inflammatory sequence in ..
  76. Muredach P Reilly; Fiscal Year: 2015
    ..in a CX3CR1-dependent manner, and CX3CR1 deficiency modulates adipose function and energy homeostasis in high-fat fed mice...
  77. SAGAR PRADEEP BAPAT; Fiscal Year: 2014
    ..These fat-resident Tregs (fTregs) may have a role in suppressing inflammation and preventing insulin resistance in the ..
  78. Timothy E Graham; Fiscal Year: 2016
    ..g., liver, muscle, and fat)...
  79. Metabolic Determinants of Cardiac Bioactive Sphingolipids in Lipid Overload
    Sarah Brice Russo; Fiscal Year: 2013
    ..Obesity and the metabolic syndrome are two overlapping conditions in which the body begins to store excess fat in non-adipose cells, including the heart...
  80. Insulin and CNS Contol of Body Weight and Food Intake
    Stephen C Woods; Fiscal Year: 2013
    ..Since most stored energy is in the form of adipose tissue (fat), and since the brain is the major controller of energy homeostasis, a fundamental requirement is that the brain ..
  81. Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis
    Jennifer J Schlezinger; Fiscal Year: 2013
    ..A newly recognized risk factor is a high fat diet and obesity...
  82. Steven A Farber; Fiscal Year: 2016
    ..the dynamic regulatory signals that coordinate absorption and transport of fatty acids (FA), and morphogenesis and fat storage in adipose tissues, remain unclear...
  83. Allison W Xu; Fiscal Year: 2016
    ..by applicant): Leptin is an adipocyte-derived hormone that circulates at levels proportional to the body's fat mass, which conveys the abundance of peripheral energy stores to the brain...
  84. Brown Adipose Tissue Quantification Using Magnetic Resonance Imaging
    E Brian Welch; Fiscal Year: 2013
    ..To achieve these goals, we will pursue the following specific aims: [1] Develop and optimize MRI measurements of fat signal fraction (FSF), water longitudinal magnetization relaxation rate (T1_H2O), water apparent diffusion ..
  85. ERICA LYN STONE; Fiscal Year: 2015
    ..In this application I propose to 1) investigate the role of T cell subsets in high fat diet -induced insuli resistance and glucose intolerance, 2) investigate the homing of T regulatory cells to the ..
  86. MICHAL MATEUSZ MASTERNAK; Fiscal Year: 2014
    The long-term goal of our research is to determine the effects of visceral fat on insulin sensitivity and longevity...
  87. ANDREW JESS DANNENBERG; Fiscal Year: 2015
    ..inflammation, elevated COX-2 expression and increased aromatase levels occur in both the MG and visceral fat (VF) in mouse models of obesity...
  88. Rachana Shah; Fiscal Year: 2015
    ..models to decrease adipocyte and monocyte inflammation and prevent adipose leukocyte infiltration during high-fat feeding;in vivo human data, however, is lacking...
  89. ROSARIO G SCALIA; Fiscal Year: 2016
    ..this application demonstrate that nutrients overload causes a postprandial infiltration of neutrophils in visceral fat depots. Obviously, this acute response to dietary nutrients occurs well before weight gain and insulin resistance...
  90. Liqing Yu; Fiscal Year: 2014
    ..genetic inactivation or ezetimibe inhibition of NPC1L1 in mice was recently found to protect against high fat diet (HFD)-induced obesity (DIO) and associated metabolic disorders...
  91. Devendra K Agrawal; Fiscal Year: 2016
    ..We hypothesize that obesity-induced inflammatory phenotype of epicardial fat is exacerbated by vitamin D deficiency leading to endothelial dysfunction and enhanced intimal hyperplasia ..
  92. Raghunatha R Yammani; Fiscal Year: 2014
    ..We propose two Specific Aims: Aim 1: To determine if a high-fat diet induces ER stress and the unfolded protein response in joint tissue in vivo...
  93. RANDALL LEE MYNATT; Fiscal Year: 2016
    Considerable evidence supports the idea that oversupply of dietary fat exceeds the storage capacity of adipose tissue and leads to ectopic lipid accumulation resulting in "metabolic stress" in skeletal muscle, liver, pancreas and ..
  94. Angela R Subauste; Fiscal Year: 2014
    ..targeted towards the understanding of an extreme phenotype of insulin resistance characterized by the absence of fat: congenital generalized lipodystrophy secondary to the AGPAT2 mutation...
  95. Michael D Jensen; Fiscal Year: 2016
    ..The cellular factors related to adipocyte lipogenesis that we measured: 1) facilitated inward transport (CD36, FATP-1);2) activation of fatty acids via acyl-CoA synthetase (ACS);3) triglyceride (TG) synthesis -mediated by ..
  96. Analia Loria; Fiscal Year: 2015
    ..to model the growing epidemic of children with extremely poor dietary lifestyles, we exposed the rats to a high fat diet (HFD) as a secondary stressor...
  97. Lipocalin 2 in Inflammation and Metabolic Control
    Xiaoli Chen; Fiscal Year: 2013
    ..impaired BAT thermogenic activation by cold exposure and reduced BAT activity and browning of WAT during high fat diet-induced obesity...
  98. ELVIRA MARIE ISGANAITIS; Fiscal Year: 2015
    ..Altered body composition with increased fat mass is a key contributor to these risks, yet accelerated postnatal adipose tissue growth following prenatal ..
  99. Shingo Kajimura; Fiscal Year: 2016
    ..anti- obesity medications act to repress energy intake, either by suppressing appetite or by inhibiting intestinal fat absorption...
  100. Christopher D Gardner; Fiscal Year: 2016
    ..with SNPs from three genes (FABP2, PPARG, and ADRB2): a low carbohydrate-responsive genotype (LCG) and a low fat-responsive genotype (LFG)...
  101. Feng Liu; Fiscal Year: 2016
    ..Our preliminary studies showed that fat-specific knockout of the Growth factor receptor binding protein-10 (Grb10) in mice substantially increased mTORC1 ..