CD274

Summary

Gene Symbol: CD274
Description: CD274 molecule
Alias: B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, programmed cell death 1 ligand 1, B7 homolog 1, CD274 antigen, PDCD1 ligand 1
Species: human

Top Publications

  1. doi Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity
    Elena Gianchecchi
    Autoimmunity Laboratory, Immunology Area, Bambino Gesu Children s Hospital IRCCS, Rome, Italy
    Autoimmun Rev 12:1091-100. 2013
  2. doi PD-1/PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation
    Wieger J Norde
    Departments of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Res 71:5111-22. 2011
  3. doi Drug of the year: programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies
    Caroline Robert
    Gustave Roussy Comprehensive Cancer Center, 114 rue Edouard Vaillant, 94800 Villejuif Paris Sud, France
    Eur J Cancer 49:2968-71. 2013
  4. pmc IFN-γ-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1
    Stan de Kleijn
    Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 8:e72249. 2013
  5. ncbi T cell dysfunction by hepatitis C virus core protein involves PD-1/PDL-1 signaling
    Zhi Q Yao
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Viral Immunol 20:276-87. 2007
  6. pmc Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer
    S Muenst
    Institute of Pathology, University Hospital Basel, Schonbeinstrasse 40, CH 4032, Basel, Switzerland
    Breast Cancer Res Treat 146:15-24. 2014
  7. pmc Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
    Nobuhiro Nakamoto
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 134:1927-37, 1937.e1-2. 2008
  8. pmc PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Clin Immunol 129:132-44. 2008
  9. doi Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis
    Jun Lee
    Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Baqiao District, Xi an 710038, P R China
    J Mol Cell Cardiol 46:169-76. 2009
  10. doi Clinical significance of B7-H1 and B7-1 expressions in pancreatic carcinoma
    Liancai Wang
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, 277 West Yanta Road, Xi an, 710061, Shaanxi Province, China
    World J Surg 34:1059-65. 2010

Research Grants

  1. Enhancing TB vaccine with gene silencing
    Jinhee Lee; Fiscal Year: 2013
  2. Regulatory Costimulatory Pathways &Fetomaternal Tolerance
    Indira Guleria; Fiscal Year: 2012
  3. Defu Zeng; Fiscal Year: 2016
  4. Ulrich H von Andrian; Fiscal Year: 2016
  5. Anti-viral immune responses in lymph node
    Ulrich H von Andrian; Fiscal Year: 2012
  6. Orin Bloch; Fiscal Year: 2016
  7. Role of ICOS-B7h Regulatory Costimulatory Pathway in Fetomaternal Tolerance
    Indira Guleria; Fiscal Year: 2010
  8. Role of Negative T Cell Costimulatory Pathways in Allograft Rejection and Toleran
    Mohamed H Sayegh; Fiscal Year: 2012
  9. SUZANNE LOUISE TOPALIAN; Fiscal Year: 2016
  10. Role and mechanism of negative costimulatory pathways in EAE
    Samia J Khoury; Fiscal Year: 2010

Detail Information

Publications199 found, 100 shown here

  1. doi Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity
    Elena Gianchecchi
    Autoimmunity Laboratory, Immunology Area, Bambino Gesu Children s Hospital IRCCS, Rome, Italy
    Autoimmun Rev 12:1091-100. 2013
    ..We finally speculate on the possible development of novel therapeutic treatments in human autoimmunity by modulating the PD-1/PD-L1 pathway. ..
  2. doi PD-1/PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation
    Wieger J Norde
    Departments of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Res 71:5111-22. 2011
    ..Furthermore, they suggest that blocking the PD-1 immune checkpoint offers an appealing immunotherapeutic strategy following alloSCT in patients with recurrent or relapsed disease...
  3. doi Drug of the year: programmed death-1 receptor/programmed death-1 ligand-1 receptor monoclonal antibodies
    Caroline Robert
    Gustave Roussy Comprehensive Cancer Center, 114 rue Edouard Vaillant, 94800 Villejuif Paris Sud, France
    Eur J Cancer 49:2968-71. 2013
    ..Because of all these reasons PD-1/PD-L1 antibodies are considered 'drug of the year'...
  4. pmc IFN-γ-stimulated neutrophils suppress lymphocyte proliferation through expression of PD-L1
    Stan de Kleijn
    Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 8:e72249. 2013
    ..Specific stimulation of neutrophils present at the inflammatory sites might therefore have a pivotal role in regulating lymphocyte-mediated inflammation and autoimmune disease. ..
  5. ncbi T cell dysfunction by hepatitis C virus core protein involves PD-1/PDL-1 signaling
    Zhi Q Yao
    Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    Viral Immunol 20:276-87. 2007
    ..This upregulation of the PD-1 and PDL-1 pathway in humans represents a novel and perhaps common mechanism by which a virus usurps host machinery to facilitate persistence...
  6. pmc Expression of programmed death ligand 1 (PD-L1) is associated with poor prognosis in human breast cancer
    S Muenst
    Institute of Pathology, University Hospital Basel, Schonbeinstrasse 40, CH 4032, Basel, Switzerland
    Breast Cancer Res Treat 146:15-24. 2014
    ..This finding has important implications for the application of antibody therapies targeting the PD-1/PD-L1 signaling pathway in this disease. ..
  7. pmc Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization
    Nobuhiro Nakamoto
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 134:1927-37, 1937.e1-2. 2008
    ..As hepatitis C virus (HCV) persists in the liver with immune-mediated disease pathogenesis, we examined the role of PD-1/PD-L pathway in antigen-specific CD8 T-cell dysfunction in the liver and blood of HCV-infected patients...
  8. pmc PDL-1 upregulation on monocytes and T cells by HIV via type I interferon: restricted expression of type I interferon receptor by CCR5-expressing leukocytes
    Adriano Boasso
    Experimental Immunology Branch, National Cancer Institute NCI, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Clin Immunol 129:132-44. 2008
    ..Finally, T cell proliferation was improved by PDL-1 blockade in HIV-treated PBMC. In the setting of HIV infection, IFN-alpha may negatively affect T cell responses by inducing PDL-1...
  9. doi Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis
    Jun Lee
    Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Baqiao District, Xi an 710038, P R China
    J Mol Cell Cardiol 46:169-76. 2009
    ....
  10. doi Clinical significance of B7-H1 and B7-1 expressions in pancreatic carcinoma
    Liancai Wang
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi an Jiaotong University, 277 West Yanta Road, Xi an, 710061, Shaanxi Province, China
    World J Surg 34:1059-65. 2010
    ..Aberrant B7-H1 and B7-1 expressions may help pancreatic carcinoma (PC) cells escape immune attack; these molecules can be considered as prognostic markers for patients with PC who have undergone radical resection...
  11. doi Antigen-specific transfer of functional programmed death ligand 1 from human APCs onto CD8+ T cells via trogocytosis
    Regina Gary
    Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen Nuremberg, Erlangen, D 91054, Germany
    J Immunol 188:744-52. 2012
    ..The transfer of functionally active coinhibitory molecules from APCs onto human CD8(+) T cells could have a regulatory role in immune responses...
  12. doi PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia
    Rita Tendeiro
    Unidade de Imunologia Clinica, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Clínica de Doenças Infecciosas, Hospital de Santa Maria, Lisboa, Portugal
    AIDS 26:1065-71. 2012
    ..Here we investigated, for the first time, inhibitory molecules in HIV-2 infection, a naturally occurring attenuated form of HIV disease, associated with reduced viremia and very slow rates of CD4 T-cell decline...
  13. doi Intrahepatic expression of programmed death-1 and its ligands in patients with HBV-related acute-on-chronic liver failure
    Dayan Cao
    Institute of Immunology, PLA, Third Military Medical University, Chongqing, 400038, People s Republic of China
    Inflammation 36:110-20. 2013
    ..Our combined results suggest that the expression of PD-L1 and PD-L2 may be biomarkers to identify and diagnose ACLF, and a clear understanding of their functional roles should further elucidate the pathogenesis of this disease...
  14. doi Allogenicity of human cardiac stem/progenitor cells orchestrated by programmed death ligand 1
    Laura Lauden
    Institut National de la Santé et de la Recherche Médicale UMRS940, Institut Universitaire d Hematologie, Université Paris Diderot and Laboratoire d Immunologie et d Histocompatibilité, Hopital Saint Louis, Paris, France
    Circ Res 112:451-64. 2013
    ..Although this has enhanced prospects of using allogeneic CPC for cardiac repair, the mechanisms regulating the behavior of these allogeneic cells, which are central to clinical applications, remain poorly understood...
  15. pmc The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia
    Davide Brusa
    Human Genetics Foundation HuGeF and Department of Medical Sciences, University of Turin, Turin, Italy
    Haematologica 98:953-63. 2013
    ..These observations suggest that pharmacological manipulation of the PD-1/PD-L1 axis may contribute to restoring T-cell functions in the chronic lymphocytic leukemia microenvironment...
  16. pmc Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia
    Lisa Christiansson
    Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    PLoS ONE 8:e55818. 2013
    ..These escape mechanisms should be monitored in trials to understand their importance and how to overcome the immune suppression...
  17. pmc Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1)
    Vamsidhar Velcheti
    Department of Medical Oncology and Pathology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Thorac Oncol 8:803-5. 2013
    ..2%) with SCs are positive for PD-L1 and their levels are higher than in conventional non-small-cell lung carcinoma. These results provide rationale for the potential use of targeted immunotherapy in lung SCs...
  18. doi Programmed death ligand-1 over-expression correlates with malignancy and contributes to immune regulation in ovarian cancer
    Christian J Maine
    Department of Medicine, Imperial College London, London, UK
    Cancer Immunol Immunother 63:215-24. 2014
    ....
  19. pmc Staphylococcus aureus convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) T cells via the PD-1/PD-L1 axis
    Hardis Rabe
    Department of Rheumatology and Inflammation Research, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Immunology 141:467-81. 2014
    ..aureus possess an ability to convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) Treg cells via the PD-1/PD-L1 axis...
  20. pmc Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    Janis M Taube
    Departments of Dermatology, Pathology, Oncology, and
    Clin Cancer Res 20:5064-74. 2014
    ..Immunomodulatory drugs differ in mechanism-of-action from directly cytotoxic cancer therapies. Identifying factors predicting clinical response could guide patient selection and therapeutic optimization...
  21. ncbi Differential binding properties of B7-H1 and B7-DC to programmed death-1
    Pornpan Youngnak
    Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Biochem Biophys Res Commun 307:672-7. 2003
    ..Our results suggest that the differential binding properties of B7-H1 and B7-DC may be responsible for differential contributions of these two PD-1 ligands to immune responses...
  22. pmc PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity
    Irina V Pinchuk
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0366, USA
    Gastroenterology 135:1228-1237, 1237.e1-2. 2008
    ..In the normal human colon, CMFs represent a distinct population of major histocompatibility complex class II(+) cells involved in the regulation of mucosal CD4(+) T-cell responses...
  23. pmc Unexpected acceleration of type 1 diabetes by transgenic expression of B7-H1 in NOD mouse peri-islet glia
    Jason Yantha
    Neuroscience and Mental Health program, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Diabetes 59:2588-96. 2010
    ..To distinguish between these alternatives, we sought to suppress pSC autoimmunity by transgenic expression of the negative costimulatory molecule B7-H1 in NOD pSC...
  24. pmc PD-L1 and PD-L2 differ in their molecular mechanisms of interaction with PD-1
    Marguerite Ghiotto
    Institut National de la Sante et de la Recherche Medicale, Unité 891, Centre de Recherche en Cancerologie de Marseille, Marseille, France
    Int Immunol 22:651-60. 2010
    ..These data further emphasize the differential molecular mechanisms of interaction of PD-L1 and PD-L2 with PD-1, and suggest possible new approach for the therapy of chronic infection, cancer and transplantation...
  25. pmc Hepatic B7 homolog 1 expression is essential for controlling cold ischemia/reperfusion injury after mouse liver transplantation
    Shinya Ueki
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 54:216-28. 2011
    ..b>B7 homolog 1 (B7-H1), a recently identified member of the B7 family, is known to play important roles in regulating local ..
  26. ncbi B7-homolog 1 expression by human glioma: a new mechanism of immune evasion
    Rick Wilmotte
    Laboratory of Tumor Immunology, Division of Oncology, University Hospital Geneva, Geneva, Switzerland
    Neuroreport 16:1081-5. 2005
    ..b>B7 homolog 1 is a member of the B7 family of costimulatory molecules implicated in the negative regulation of T cell immune ..
  27. doi Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients
    Mina Hayashi
    Department of Endocrinology and Metabolism, Internal Medicine, University of the Ryukyus, Uehara 207, Nishihara, Okinawa 903 0215, Japan
    Eur J Endocrinol 158:817-22. 2008
    ..This inhibition down-regulates the immune responses. The association of a PD-L1 polymorphism with Graves' disease (GD) was studied...
  28. doi Expression of tolerance associated gene-1, a mitochondrial protein inhibiting T cell activation, can be used to predict response to immune modulating therapies
    Kathrin Keeren
    Institute of Medical Immunology, Charité University Medicine Berlin Campus Mitte, Germany
    J Immunol 183:4077-87. 2009
    ..Inhibition of proliferation was dependent on enhanced PDL1 expression of APCs...
  29. doi Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility
    Anna L Mitchell
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom
    J Clin Endocrinol Metab 94:5139-45. 2009
    ..Our aim was to determine whether variants in PD-L1 are also associated with autoimmune Addison's disease (AAD) and to replicate the previous association in patients with GD from the United Kingdom...
  30. doi Immunological effects of sublingual immunotherapy: clinical efficacy is associated with modulation of programmed cell death ligand 1, IL-10, and IgG4
    Stefania Piconi
    Department of Allergic Diseases and Clinical Immunology, L Sacco Hospital, Milan, Italy
    J Immunol 185:7723-30. 2010
    ..A more detailed understanding of the interaction of allergen and APCs within the oral mucosa will allow improved targeting of allergy vaccine...
  31. pmc Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice
    Julie A Lucas
    Laboratory of Molecular Autoimmune Disease, Renal Division, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 181:2513-21. 2008
    ..Taken together, we suggest that PD-L1 expression is central to autoimmune heart and lung disease in lupus-susceptible (MRL) mice...
  32. doi B7-H1 up-regulation impairs myeloid DC and correlates with disease progression in chronic HIV-1 infection
    Xicheng Wang
    Department of Infectious Diseases, Beijing You an Hospital Affiliated to Capital Medical University, China
    Eur J Immunol 38:3226-36. 2008
    ....
  33. pmc Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
    Michael R Green
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Blood 116:3268-77. 2010
    ..1 amplification is a disease-specific structural alteration that increases both the gene dosage of PD-1 ligands and their induction by JAK2, defining the PD-1 pathway and JAK2 as complementary rational therapeutic targets...
  34. pmc The PD-1 pathway in tolerance and autoimmunity
    Loise M Francisco
    Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunol Rev 236:219-42. 2010
    ..Thus, this review also discusses how the PD-1 pathway regulates a number of autoimmune diseases and the therapeutic potential of PD-1: PD-L modulation...
  35. doi Programmed death ligand 1 is expressed by non-hodgkin lymphomas and inhibits the activity of tumor-associated T cells
    David J Andorsky
    Division of Hematology and Oncology, Department of Medicine, and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Clin Cancer Res 17:4232-44. 2011
    ..PD-L1 is aberrantly expressed on some epithelial malignancies and Hodgkin lymphomas and may prevent effective host antitumor immunity. The role of PD-L1 in non-Hodgkin lymphomas (NHL) is not well characterized...
  36. ncbi PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children
    Ronghua Ni
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashiku, Fukuoka 812 8582, Japan
    Hum Genet 121:223-32. 2007
    ..In conclusion, the genetic evaluation by association study demonstrated that the PD-1 gene was a predisposing gene to the development of T1D mellitus in the Japanese population...
  37. pmc Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    Junzo Hamanishi
    Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 104:3360-5. 2007
    ..The PD-1/PD-L pathway can be a good target for restoring antitumor immunity in ovarian cancer...
  38. doi Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions
    Takeshi Nagamatsu
    Department of Obstetrics, Gynecology and Women s Health, University of Missouri Columbia, One Hospital Drive, Columbia, MO 65201, USA
    Hum Reprod 24:3160-71. 2009
    ..B7-H1 and B7-DC on peripheral antigen-presenting cells (APC) typically inhibit T cell activation after binding to their corresponding receptor, programmed death-1 (PD-1)...
  39. pmc Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions
    Ke Wu
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 69:8067-75. 2009
    ..Our data indicate that the B7-H1/PD-1 axis contributes to immune suppression in human HCC, with blockade of this pathway carrying important therapeutic implications...
  40. doi The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis
    Amalia P Raptopoulou
    University of Crete School of Medicine, Heraklion, Greece
    Arthritis Rheum 62:1870-80. 2010
    ..The aim of this study was to examine the role of PD-1/PDL-1 in the regulation of human and murine RA...
  41. doi Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis
    Ivana B Alvarez
    Department of Biological Chemistry, University of Buenos Aires, School of Sciences, Buenos Aires, Argentina
    J Infect Dis 202:524-32. 2010
    ..Together, we described a novel inhibitory role played by PD-1:PD-L interactions in innate immunity in tuberculosis...
  42. pmc Innate IFN-γ is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection
    Jared H Rowe
    Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA
    J Immunol 189:876-84. 2012
    ..Thus, innate IFN-γ is essential for PDL-1-mediated T cell stimulation...
  43. doi Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus
    George K Bertsias
    University of Crete Medical School, Heraklion, Crete, Greece
    Arthritis Rheum 60:207-18. 2009
    ..We undertook this study to determine the expression and function of PD-1 in SLE patients...
  44. pmc Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction
    Shengdian Wang
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 197:1083-91. 2003
    ..Our results reveal unique binding characteristics of B7-H1 and B7-DC and provide direct evidence for an independent costimulatory receptor other than PD-1...
  45. ncbi Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes
    C Nielsen
    Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
    Tissue Antigens 62:492-7. 2003
    ..92]. The associated allele is previously shown to alter a transcription factor-binding site (RUNX1/AML1), and the results of this study suggest that this allele could act as an additional susceptibility allele to type 1 diabetes...
  46. ncbi Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers
    Juro Nakanishi
    Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
    Cancer Immunol Immunother 56:1173-82. 2007
    ....
  47. ncbi Cutting edge: Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy
    Woo Sung Chang
    Laboratory of Immunology and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea
    J Immunol 181:6707-10. 2008
    ..Our findings suggest that the PD-1/PD-L1 interaction is essential for the induction and maintenance of iNKT cell anergy...
  48. ncbi B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    H Dong
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Nat Med 5:1365-9. 1999
    ..Our studies thus define a previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses...
  49. pmc Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    G J Freeman
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1027-34. 2000
    ..PD-L1 expression on nonlymphoid tissues and its potential interaction with PD-1 may subsequently determine the extent of immune responses at sites of inflammation...
  50. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
    ..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
  51. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
    ..These findings have implications for the design of T cell-based cancer immunotherapy...
  52. ncbi B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis
    Melissa M Mazanet
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    J Immunol 169:3581-8. 2002
    ..Our results demonstrate that B7-H1 negatively regulates cytokine synthesis in T cells activated by ECs...
  53. ncbi B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression
    Daria Trabattoni
    Chair of Immunolgy, Dipartimento Scienze Precliniche Laboratorio Integrato Tecnologie Avanzate DISP LITA Vialba, University of Milano, Milano, Italy
    Blood 101:2514-20. 2003
    ..B7-H1 is a surrogate marker potentially involved in AIDS disease progression...
  54. ncbi Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production
    Julia A Brown
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:1257-66. 2003
    ..PD-L1 is also highly expressed on most carcinomas but minimally expressed on adjacent normal tissue suggesting a role in attenuating antitumor immune responses...
  55. ncbi B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy
    Nicole Selenko-Gebauer
    Institute of Immunology, University of Vienna Medical School, Vienna, Austria
    J Immunol 170:3637-44. 2003
    ..Our results thus demonstrate that the mAb DF272-defined surface molecule B7-H1 represents a unique receptor structure on DC that might play a role in the induction and maintenance of T cell anergy...
  56. ncbi Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana, USA
    Nat Med 9:562-7. 2003
    ..Therefore, upregulation of B7-H1 on MDCs in the tumor microenvironment downregulates T-cell immunity. Blockade of B7-H1 represents one approach for cancer immunotherapy...
  57. ncbi The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells
    Atsushi Nakazawa
    Immunobiology Center, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Gastroenterology 126:1347-57. 2004
    ..Our aim was to determine whether IECs express novel B7 family members and whether these molecules play a role in IEC:T-cell interactions...
  58. ncbi B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    Jun Konishi
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Clin Cancer Res 10:5094-100. 2004
    ..Furthermore, we examined the correlation between B7-H1 expression on tumor cells and the number of tumor-infiltrating lymphocytes (TILs) or PD-1 expression on TILs...
  59. ncbi Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis
    Bettina Schreiner
    Department of General Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Neuroimmunol 155:172-82. 2004
    ..IFN-beta up-regulates B7-H1 in vitro and in MS patients in vivo and might represent a novel mechanism how IFN-beta acts as a negative modulator on APC T-cell interactions in the periphery...
  60. ncbi Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer
    Yuichiro Ohigashi
    Department of Surgery, Nara Medical University School of Medicine, Nara, Japan
    Clin Cancer Res 11:2947-53. 2005
    ..In this study, we investigated the expression of PD-L1 and PD-L2 in human esophageal cancer to define their clinical significance in patients' prognosis after surgery...
  61. ncbi IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells
    Sang Keun Lee
    Institute of Traditional Medicine and Bioscience, Daejeon University, 96 3 Yongun dong, Daejeon 300 716, Republic of Korea
    J Dermatol Sci 40:95-103. 2005
    ..Programmed cell death ligand 1 (B7-H1) was recently cloned in antigen presenting cells (APCs) and represents a third member of the B7 family. Thus, B7-H1 may be a novel target for clinical intervention in human inflammatory disease...
  62. ncbi Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjögren's syndrome
    Masaya Kobayashi
    Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Rheumatol 32:2156-63. 2005
    ..To investigate the role of the PD-1/PD-L system in the pathology of Sjögren's syndrome (SS), we examined the expression of PD-1 and its ligand PD-L1 in salivary lymphocytes and salivary glands from patients with SS...
  63. ncbi Expression of B7-H1 in inflammatory renal tubular epithelial cells
    Yongwen Chen
    Institute of Immunology, PLA, The Third Military Medical University, Chongqing, PR China
    Nephron Exp Nephrol 102:e81-92. 2006
    ....
  64. ncbi Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro
    Christian Blank
    Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany
    Int J Cancer 119:317-27. 2006
    ..In summary, our data suggest that PD-L1/PD-1 interactions negatively regulate T cell effector functions predominantly in the absence of exogenous cytokine support, indicating an important role for this pathway in tumor evasion...
  65. ncbi Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance
    Changping Wu
    The Third Affiliated Hospital of Suzhou University, Changzhou 213003, China
    Acta Histochem 108:19-24. 2006
    ....
  66. ncbi PD-L1 is induced in hepatocytes by viral infection and by interferon-alpha and -gamma and mediates T cell apoptosis
    Marcus Muhlbauer
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    J Hepatol 45:520-8. 2006
    ..Absence of PD-1 enhanced proliferation of T cells in adenovirus-infected livers and resulted in a rapid clearance of the virus. Here, we aimed to get more insight into hepatic PD-L1 expression, regulation and function...
  67. ncbi Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1)
    Adriana J LaGier
    Evelyn F and William L McKnight Vision Research Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
    Hum Immunol 67:568-78. 2006
    ..We engineered overexpression of B7-H1 in EC (B7H1-EC) to evaluate whether this manipulation could reduce T-cell responses even further...
  68. ncbi Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway
    Jizhong Liu
    Institut National de la Sante et de la Recherche Medicale, Unité 837, Institut de Recherche sur le Cancer de Lille, France
    Blood 110:296-304. 2007
    ..Thus, B7-H1 expression by MM cells represents a possible immune escape mechanism that could be targeted therapeutically through inhibition of MyD88/TRAF6 and MEK/ERK/STAT1...
  69. ncbi Expression of B7-H1 in breast cancer patients is strongly associated with high proliferative Ki-67-expressing tumor cells
    Hazem Ghebeh
    Tumor Immunology Unit, Department Biological and Medical Research, King Faisal Specialist Hospital and Research Center, MBC 03, P O Box 3354, Riyadh 11211, Saudi Arabia
    Int J Cancer 121:751-8. 2007
    ..The relationship between B7-H1 induction and cell proliferation was also thoroughly investigated in vitro, in which a strong link between B7-H1 expression and the presence of the proliferative Ki-67 marker was clearly demonstrated...
  70. ncbi B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B
    Liangen Chen
    Research Center of Biological Therapy, Beijing 302 Hospital, and Center for Infection and Immunity, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, China
    J Immunol 178:6634-41. 2007
    ..Our findings further support the notion that the blockade of B7-H1 may represent a novel therapeutic approach for this disease...
  71. pmc Expression of the programmed death ligand 1, B7-H1, on gastric epithelial cells after Helicobacter pylori exposure promotes development of CD4+ CD25+ FoxP3+ regulatory T cells
    Ellen J Beswick
    Departmen tof Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Infect Immun 75:4334-41. 2007
    ..The functional role of these Treg cells was assessed in proliferation assays when the cells were cocultured with activated T cells, which effectively decreased proliferation of the cells...
  72. ncbi Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis
    Ping Zhang
    Center for Biomedical Research, University of Texas Health Center at Tyler, Tyler, TX 75708, USA
    Mol Immunol 45:1470-6. 2008
    ..Our studies reveal a potential link between chemotherapy and cancer immunoresistance...
  73. ncbi Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart
    Nir Grabie
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 116:2062-71. 2007
    ..PD-L1 is induced on cardiac endothelial cells under inflammatory conditions, but little is known about its role in regulating immune injury in the heart...
  74. ncbi Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection
    Hye Young Jeong
    Department of Microbiology, Center for Viral Disease Research, Bio Marker Research Center for Personalized Therapy, Inje University College of Medicine, Busan 614 735, Korea
    J Leukoc Biol 83:755-64. 2008
    ..Blockade of the B7-H1 pathway thus represents an attractive approach in the treatment of chronic HCV infection...
  75. doi PD-1 and its ligands in tolerance and immunity
    Mary E Keir
    Department of Pathology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115 5727, USA
    Annu Rev Immunol 26:677-704. 2008
    ..In this review, we discuss current understanding of the immunoregulatory functions of PD-1 and its ligands and their therapeutic potential...
  76. doi PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
    Ryo Yamamoto
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Blood 111:3220-4. 2008
    ..Our finding provides a potentially effective immunologic strategy for the treatment of HL...
  77. pmc The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
    David Yin Wei Lin
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook 2, 12441 Parklawn Drive, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 105:3011-6. 2008
    ..The immune receptor-like loops offer a new surface for further study and potentially the design of molecules that would affect PD-1/PD-L1 complex formation and thereby modulate the immune response...
  78. pmc FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy
    Hazem Ghebeh
    Tumor Immunology Section, King Faisal Specialist Hospital and Research Center, P, O, Box 3354, Riyadh 11211, Saudi Arabia
    BMC Cancer 8:57. 2008
    ..Therefore, we investigated TIL-expressing the B7-H1, PD-1, and FOXP3 molecules, in the microenvironment of human breast tumors and their possible association with the progression of the disease...
  79. ncbi Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis
    Javier O Jurado
    Department of Biological Chemistry, School of Sciences, University of Buenos Aires, Buenos Aires, Argentina
    J Immunol 181:116-25. 2008
    ..Together, we demonstrated that PD-1 interferes with T cell effector functions against M. tuberculosis, suggesting that PD-1 has a key regulatory role during the immune response of the host to the pathogen...
  80. pmc Interaction of human PD-L1 and B7-1
    Manish J Butte
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Immunol 45:3567-72. 2008
    ..We show that PD-L1 is induced to a higher level on CD28high T cells than on CD28low T cells upon activation. These results suggest that PD-L1 may play an important and undervalued role on human T cells...
  81. doi TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells
    Yigang Qian
    Department of Hepatobiliary Pancreatic Surgery, Key Lab of Organ Transplantation of Zhejiang Province, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Cancer Invest 26:816-21. 2008
    ..Our results elucidated the molecule mechanism of regulation of B7-H1 expression through TLR4 signaling and may suggest new strategies of down-regulating the cancer-associated B7-H1 expression for bladder cancer treatment...
  82. ncbi Clinical significance of B7-H1 (PD-L1) expression in human acute leukemia
    Xiangli Chen
    Department of Clinical Hematology, Second Hospital of Xi an Jiaotong University, Xi an, Shaanxi Province, China
    Cancer Biol Ther 7:622-7. 2008
    ..In conclusion, B7-H1 is highly expressed on leukemia cells of M5 patients, can significantly affect the immunotherapeutic efficacies of M5 patients and is a novel prognostic marker for M5...
  83. doi PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients
    T Kozako
    Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Leukemia 23:375-82. 2009
    ..These observations suggest that the PD-1/PD-L1 pathway plays a role in fostering persistent HTLV-1 infections, which may further ATLL development and facilitate immune evasion by ATLL cells...
  84. pmc PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer
    C A Crane
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Oncogene 28:306-12. 2009
    ..These observations describe a mechanism for immune escape from tumor dormancy in humans that relates to oncogenesis...
  85. ncbi Cross-linking of B7-H1 on EBV-transformed B cells induces apoptosis through reactive oxygen species production, JNK signaling activation, and fasL expression
    Yeong Seok Kim
    Department of Anatomy and Research Center for Tumor Immunology, Inje University College of Medicine, Busan, Republic of Korea
    J Immunol 181:6158-69. 2008
    ..These results provide a new concept for understanding reverse signaling through B7-H1 and another mechanism of tumor immunotherapy using anti-B7-H1...
  86. pmc Differentiation-induced post-transcriptional control of B7-H1 in human trophoblast cells
    L M Holets
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Placenta 30:48-55. 2009
    ..These results highlight a novel mechanism for regulation of B7 family proteins in the placenta...
  87. pmc Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
    Michal Marzec
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:20852-7. 2008
    ..the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells strongly express the immunosuppressive cell-surface protein CD274 (PD-L1, B7-H1), as determined on the mRNA and protein level...
  88. pmc PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV
    Debora Franceschini
    Dipartimento di Medicina Interna, Sapienza Universita di Roma, Policlinico Umberto I, Viale del Policlinico 155, Rome, Italy
    J Clin Invest 119:551-64. 2009
    ..Notably, PD-L1 blockade upregulated STAT-5 phosphorylation in Tregs ex vivo. These data suggest that PD-L1 negatively regulates Tregs at sites of chronic inflammation by controlling STAT-5 phosphorylation...
  89. pmc B7-H1 is correlated with malignancy-grade gliomas but is not expressed exclusively on tumor stem-like cells
    Yu Yao
    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China
    Neuro Oncol 11:757-66. 2009
    ....
  90. pmc Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    Dong Ming Kuang
    State Key Laboratory of Biocontrol, Sun Yat Sen University, Guangzhou 510 275, China
    J Exp Med 206:1327-37. 2009
    ..Thus, expression of PD-L1 on activated monocytes/Mphi may represent a novel mechanism that links the proinflammatory response to immune tolerance in the tumor milieu...
  91. pmc Chronically inflamed livers up-regulate expression of inhibitory B7 family members
    Rachel Kassel
    Carter Immunology Center, Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
    Hepatology 50:1625-37. 2009
    ..The degree of necroinflammation correlates with expression levels of PD-1 family members...
  92. ncbi Intrahepatic PD-1/PD-L1 up-regulation closely correlates with inflammation and virus replication in patients with chronic HBV infection
    Zhunyi Xie
    Laboratory of Immunoregulation, Institute of Immunology, PLA, Third Military Medical University, Chongqing, PR China
    Immunol Invest 38:624-38. 2009
    ..Our data suggest that the intrahepatic interaction of PD-1 and PD-L1 might play an important role in balancing the immune response to HBV and immune-mediated liver damage in chronic HBV infection...
  93. ncbi [Expression of B7-H1 protein in human pancreatic carcinoma tissues and its clinical significance]
    Xiao Ling Chen
    Department of Oncology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215006, P R China
    Ai Zheng 28:1328-32. 2009
    ..This study was to probe into the correlation between the expression level of B7-H1 protein in pancreatic carcinoma tissues and clinicopathological characteristics and prognosis...
  94. pmc Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1
    Shoba Amarnath
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Biol 8:e1000302. 2010
    ..This identification of a human Treg downstream cellular effector (DC) and molecular mechanism (PD-L1) will facilitate the rational design of clinical trials to modulate alloreactivity...
  95. doi PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients
    Feng Shi
    Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China
    Int J Cancer 128:887-96. 2011
    ..Therefore, this study extends our knowledge of the role of the PD-1/PD-L1 pathway in tumor evasion and provides evidence for a new therapeutic target in HCC patients...
  96. doi PD-L1 expression on tolerogenic APCs is controlled by STAT-3
    Sabine J Wölfle
    Department for Infectious Diseases, Medical Microbiology and Hygiene, University of Heidelberg, Germany
    Eur J Immunol 41:413-24. 2011
    ..Hence, during DC differentiation TLR agonists induce a STAT-3-mediated expression of PD-L1 and favor the development of tolerogenic APCs...
  97. pmc Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis
    Finlay W McNab
    Division of Immunoregulation, MRC National Institute for Medical Research, London, UK
    Eur J Immunol 41:1941-7. 2011
    ....
  98. pmc Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80
    Samuel T Haile
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    J Immunol 186:6822-9. 2011
    Programmed death ligand 1 (PDL1, or B7-H1) is expressed constitutively or is induced by IFN-γ on the cell surface of most human cancer cells and acts as a "molecular shield" by protecting tumor cells from T cell-mediated destruction...
  99. pmc The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo
    Jun Yang
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 187:1113-9. 2011
    The programmed death ligand 1 (PDL1)/programmed death 1 (PD1) costimulatory pathway plays an important role in the inhibition of alloimmune responses as well as in the induction and maintenance of peripheral tolerance...
  100. pmc Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma
    Bao Ju Wang
    Division of Clinical Immunology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    World J Gastroenterol 17:3322-9. 2011
    ..To investigate the expression of programmed death (PD)-1, PD ligand 1 (PD-L1) and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma (HCC)...
  101. pmc Upregulation of circulating PD-L1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma
    Zhen Zeng
    Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, China
    PLoS ONE 6:e23621. 2011
    ..This study was designed to evaluate the association between circulating PD-L1/PD-1 and prognosis after cryoablation in patients with HBV-related hepatocellular carcinoma (HCC)...

Research Grants37

  1. Enhancing TB vaccine with gene silencing
    Jinhee Lee; Fiscal Year: 2013
    ..g. IL-10), DC ligands for T cell inhibitory receptors (e.g. PDL1 and PDL2), and intracellular signaling regulators (e.g. SOCS1, SOCS2, and IRAK-M)...
  2. Regulatory Costimulatory Pathways &Fetomaternal Tolerance
    Indira Guleria; Fiscal Year: 2012
    ..Recent studies from our group have demonstrated that negative T cell costimulatory pathway PD-1-PDL1 is critical for maintaining fetomaternal tolerance...
  3. Defu Zeng; Fiscal Year: 2016
    ..We also observed that donor Treg expansion was markedly reduced in MHC II-/- and B7H1-/- recipients as well as in wild-type (WT) recipients treated with an IFN-? neutralizing antibody...
  4. Ulrich H von Andrian; Fiscal Year: 2016
    ..Sharpe and Wherry will visualize the effects of the negative costimulatory pathways, PD-1:PD-L1, PD-1:PD-L2 and PDL1 :B7.1 on antiviral immunity to influenza and LCMV. In Project 3. Dr...
  5. Anti-viral immune responses in lymph node
    Ulrich H von Andrian; Fiscal Year: 2012
    ..Sharpe and Wherry will visualize the effects of the negative costimulatory pathways, PD-1:PD-L1, PD-1:PD-L2 and PDL1 :B7.1 on antiviral immunity to influenza and LCMV. In Project 3. Dr...
  6. Orin Bloch; Fiscal Year: 2016
    ..B7-Homologue 1 (B7H1), also known as programmed death ligand 1 (PD-L1), is a cell surface protein that inhibits anti-tumor immunity...
  7. Role of ICOS-B7h Regulatory Costimulatory Pathway in Fetomaternal Tolerance
    Indira Guleria; Fiscal Year: 2010
    ..Recent studies from our group has demonstrated that negative T cell costimulatory pathway PD-1-PDL1 is critical for maintaining fetomaternal tolerance...
  8. Role of Negative T Cell Costimulatory Pathways in Allograft Rejection and Toleran
    Mohamed H Sayegh; Fiscal Year: 2012
    ..aims are: AIM I: To investigate the functions and mechanisms of the negative T cell costimulatory pathway PD-1:PDL1/PDL2 in alloimmune responses in vivo using models of solid organ and tissue (skin) transplantation...
  9. SUZANNE LOUISE TOPALIAN; Fiscal Year: 2016
    ..The major ligand for PD-1 is B7-H1 (PDL1), a B7 family member normally expressed by several leukocyte subsets upon activation, and aberrantly expressed in ..
  10. Role and mechanism of negative costimulatory pathways in EAE
    Samia J Khoury; Fiscal Year: 2010
    ..Recently, other pathways that provides negative signaling to T cells has been described, the PD1-PDL1/2 pathway, and the B7-H3 and B7-H4 pathways...
  11. Role of PD-L1 in Ocular Toxoplasmosis
    Ira J Blader; Fiscal Year: 2012
    ..hypothesis is that retinal expression of MHC Class II and the negative costimulatory molecule PD-L1 (also known as B7H1) are important in regulating the T-cells...
  12. PDL1-based rAAV-mediated gene therapy for mouse T1D
    Jide Tian; Fiscal Year: 2007
    ..However, little is known the role of PDL1 -related signaling in T cell responses to (3-cell antigens and the T1D process...
  13. Role and Mechanism of PDI-PDL Pathway in EAE
    Samia Khoury; Fiscal Year: 2007
    ..Recently, another pathway that provides negative signaling to T cells has been described, the PD1- PDL1/2 pathway...
  14. Predicting Melanoma Response to BAY 43-9006/Chemotherapy
    Harriet Kluger; Fiscal Year: 2008
    ..We will assess individual markers as well as panels of markers. [unreadable] [unreadable]..
  15. Tuberous Sclerosis: Mutations and Murine Models
    David Kwiatkowski; Fiscal Year: 2006
    ..Last, the in vivo interaction in the mouse between Tsc2 null alleles and null alleles for p53, p27KIP, p21CIP, Msh2, and gelsolin will be explored. ..
  16. Preclinical Studies of Rapamycin for TSC Brain Disease
    David Kwiatkowski; Fiscal Year: 2006
    ..These studies will provide critical preclinical data that will support the use of rapamycin or analogues in the treatment of TSC patients with cortical tubers and subependymal giant cell astrocytomas. ..
  17. GENOTYPING CENTER FOR INNATE IMMUNITY PGA
    David Kwiatkowski; Fiscal Year: 2004
    ..abstract_text> ..
  18. GELSOLIN: ROLES IN APOPTOSIS AND TUMOR DEVELOPMENT
    David Kwiatkowski; Fiscal Year: 2003
    ..The results should provide major insight into the function of gelsolin in these processes and provide potential therapeutic strategies to modulate apoptosis and malignant potential. ..
  19. MURINE MODELS OF TSC 1: MECHANISMS AND THERAPIES
    David Kwiatkowski; Fiscal Year: 2001
    ....
  20. Impaired T cell function by HCV core
    YOUNG HAHN; Fiscal Year: 2008
    ..In addition, they will provide a basis for the rational design of vaccines and novel therapeutic agents to block the action of HCV core/gC1qR on suppression of T cell function. ..
  21. Effector Mechanisms in Graft Tolerance
    Randolph J Noelle; Fiscal Year: 2010
    ..New evidence strongly implicates IL-9 and mast cells as elements that may be important to peripheral tolerance, and studies are presented to functionally implicate their involvement. ..
  22. Tumor-induced immune suppression.
    Suzanne Ostrand Rosenberg; Fiscal Year: 2010
    ..abstract_text> ..
  23. Alteration of innate immunity by HCV core
    YOUNG HAHN; Fiscal Year: 2009
    ..In addition, they will provide a basis for the rational design of novel therapeutic agents to block the action of HCV-induced immunosuppression. ..
  24. BCMA: Controlling the survival of differentiated B cells
    Randolph Noelle; Fiscal Year: 2008
    ..To investigate the molecular basis of BlyS/APRIL-BCMA signaling in plasma cells and MM cell lines. To develop BCMA as a therapeutic target in MM. ..
  25. Regulation of Dendritic Cells and Cell Mediated Immunity by TNF family members
    Randolph Noelle; Fiscal Year: 2007
    ..We hypothesize that the combined use of TLR and CD40 agonists will be effective immunotherapeutic approaches to manage tumor models of established disease. ..
  26. Mechanisms of CD40 signaling in B lympocytes in vivo
    Randolph Noelle; Fiscal Year: 2006
    ..Assuming the development of autoimmunity in Tg CD40zip mice, mutations in the TRAF binding sites of CD40zip, will be engineered to evaluate the contribution of specific TRAFs to the development of autoimmunity. ..
  27. Purchase of a Xenogen's IVIS Imaging System 200 Workstation
    Randolph Noelle; Fiscal Year: 2006
    ..abstract_text> ..
  28. CNS-RESTRICTED APC FUNCTION IN EAE
    Randolph Noelle; Fiscal Year: 2005
    ..Together, these studies will help define the role of microglial cells as APCs during the priming and effector phase in EAE. ..
  29. Tumor cell antigen presentation to CD4 + T lymphocytes
    Suzanne Ostrand Rosenberg; Fiscal Year: 2004
    ..of anti-tumor immunity? Which effector cells, cytokines, and chemokines are induced during therapy? 5) Does tumor burden correlate with tumor-induced immuno-suppression? Does surgical removal of primary tumor reverse mmuno-suppression? ..
  30. COGNATE ACTIVATION OF B LYMPHOCYTES
    Randolph Noelle; Fiscal Year: 2003
    ..Transitions from TI to TD-type responses will held resolve how each of these components influence B cell immunopoeisis. ..
  31. Affimetrix High Density Workstation
    Randolph Noelle; Fiscal Year: 2002
    ..abstract_text> ..
  32. ASSEMBLY/REGULATION OF CD40 RECEPTOR COMPLEX IN B CELLS
    Randolph Noelle; Fiscal Year: 2001
    ..Studies are proposed which will evaluate if engagement of one TNFR family member can prohibit the recruitment of TRAFs by other family members; and what the functional consequences of receptor desensitization are to the B-cell. ..
  33. Molecular Basis of Suppression of SLE by CD8+ Ti Cells
    Ram Singh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. (m) TOR signaling in EBV-associated lymphomas
    Mariusz Wasik; Fiscal Year: 2007
    ..role of TOR signaling in cell transformation of the lymphoma cells These studies may result in novel diagnostic and therapeutic approaches to the EBV-associated lymphomas in HIV/AIDS and other patients. ..
  35. Jak/STAT signaling in human T-cell lymphomas
    Mariusz A Wasik; Fiscal Year: 2010
    ....
  36. Accelerated arthritis in E and P selectin deficient mice
    Jeffrey Ruth; Fiscal Year: 2007
    ..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. [unreadable] [unreadable] [unreadable]..