Genomes and Genes
Gene Symbol: CD25
Description: interleukin 2 receptor subunit alpha
Alias: CD25, IDDM10, IL2R, IMD41, TCGFR, p55, interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2R subunit alpha, TAC antigen, interleukin 2 receptor, alpha
Publications402 found, 100 shown here
- Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresourceCalliope A Dendrou
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
Nat Genet 41:1011-5. 2009..to show that differences in surface expression of the human interleukin-2 (IL-2) receptor alpha (IL2RA, or CD25) protein are restricted to particular immune cell types and correlate with several haplotypes in the IL2RA region ..
- Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell functionGarima Garg
Department of Immunobiology, School of Medicine, King s College London, London SE1 9RT, United Kingdom
J Immunol 188:4644-53. 2012Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory ..
- The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elementsH P Kim
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
Immunity 15:159-72. 2001..Thus, the IL-2 inducibility of the IL-2Ralpha gene is unexpectedly mediated by two widely separated regulatory Stat5-dependent elements, located both upstream and downstream of the transcription initiation sites...
- Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptorDeborah J Stauber
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:2788-93. 2006..The IL-2/gamma(c) interface itself exhibits the smallest buried surface and the fewest hydrogen bonds in the complex, which is consistent with its promiscuous use in other cytokine receptor complexes...
- Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptorN Sharfe
Department of Pediatrics, University of Toronto, ON, Canada
Proc Natl Acad Sci U S A 94:3168-71. 1997..here a novel human immune aberration arising from a truncation mutation of the interleukin-2 receptor alpha chain (CD25), a subunit of the tripartite high-affinity receptor for interleukin 2...
- Variant of TYR and autoimmunity susceptibility loci in generalized vitiligoYing Jin
Human Medical Genetics Program, School of Medicine, University of Colorado, P O Box 6511, Mailstop 8300, Aurora, CO 80045, USA
N Engl J Med 362:1686-97. 2010..Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases...
- Aggressive non-Hodgkin's lymphoma: concomitant evaluation of interleukin-2, soluble interleukin-2 receptor, interleukin-4, interleukin-6, interleukin-10 and correlation with outcomeElizabeth Fabre-Guillevin
Department of Medical Oncology, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, France
Leuk Lymphoma 47:603-11. 2006..However, sIL-2R and IL-6 measurements may improve risk assignment by IPI and allow a better prognostic evaluation of patients with intermediate prognosis NHL...
- GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell linesJanos Matko
Department of Biophysics and Cell Biology, Cell Biophysics Research Group of the Hungarian Academy of Sciences, University of Debrecen, Health Science Center, Debrecen, Hungary
Eur J Biochem 269:1199-208. 2002..gamma(c) chains constitutively expressed in detergent-resistant membrane fractions (DRMs) of T cells, IL-2Ralpha (CD25) was also found in DRMs, independently of its ligand-occupation...
- Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptorsMarcin L Pekalski
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom
J Immunol 190:2554-66. 2013..In this study we present evidence that the frequency of naive CD4 T cells that express CD25 (IL-2 receptor α-chain) increases with age on subsets of both CD31(+) and CD31(-) naive CD4 T cells...
- Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responsesLisa M Maier
Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 182:1541-7. 2009..In summary, we propose that before disease onset, strong genetic factors associated with disease risk dictate sIL-2RA levels that may be further modulated with onset of chronic systemic inflammation associated with MS...
- T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignanciesCamilla A Lindqvist
Division of Clinical Immunology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
Immunology 131:371-6. 2010..It binds to the IL-2 receptor consisting of three chains, the α (CD25), β and common γ (γc)...
- IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunityJinguo Wang
Julia McFarlane Diabetes Research Centre JMDRC and Department of Microbiology and Infectious Diseases, Institute of Inflammation, Infection and Immunity, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada T2N 4N1
Semin Immunol 21:363-71. 2009..Here, we summarize what we know about the genetics of T1D with an emphasis on the contributions of mouse Il2 and human IL2RA polymorphisms and the IL-2-IL-2R pathway to autoimmunity and, more specifically, Treg development and function...
- Shared and distinct genetic variants in type 1 diabetes and celiac diseaseDeborah J Smyth
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
N Engl J Med 359:2767-77. 2008..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
- Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptorsXinquan Wang
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, 299 Campus Drive, Fairchild D319, Stanford, CA 94305, USA
Science 310:1159-63. 2005..This complex structure provides a framework for other gammac-dependent cytokine-receptor interactions and for the engineering of improved IL-2 therapeutics...
- Risk alleles for multiple sclerosis identified by a genomewide studyDavid A Hafler
Division of Molecular Immunology, Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, and Harvard Medical School, Boston, USA
N Engl J Med 357:851-62. 2007..Multiple sclerosis has a clinically significant heritable component. We conducted a genomewide association study to identify alleles associated with the risk of multiple sclerosis...
- Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulationTodd M Brusko
Department of Pathology, University of Florida, Gainesville, Florida, United States of America
PLoS ONE 4:e7980. 2009b>CD25, a component of the IL-2 receptor, is important in T cell proliferation, activation induced cell death, as well as the actions of both regulatory (Treg) and effector (Teff) T cells...
- Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjectsMatthew W Klinker
Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA
Immunogenetics 62:101-7. 2010..These findings suggest that the IL2RA locus controls both the susceptibility to disease and its time of occurrence. Thus, we believe the IL2/IL2R axis represents a potential therapeutic target for delaying the onset of disease.
- A cis-acting regulatory variant in the IL2RA locusHui Qi Qu
Endocrine Genetics Lab, The McGill University Health Center and Montreal Children s Hospital, Montreal, Quebec, Canada
J Immunol 183:5158-62. 2009....
- Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritisSampath Prahalad
Emory University School of Medicine, Atlanta, Georgia 30322, USA
Arthritis Rheum 60:2124-30. 2009....
- A variant of the Il2ra / Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptorD A Chistiakov
Department of Molecular Diagnostics, National Research Center GosNIIgenetika, Moscow, Russia
Scand J Immunol 74:496-501. 2011Alpha-subunit of the IL-2 receptor (IL-2Rα) encoded by the IL2RA/CD25 gene binds IL-2 that plays a pivotal role in the regulation of T cell function...
- IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways?Ewald Lindner
Department of Ophthalmology, General Hospital Klagenfurt, Austria
Invest Ophthalmol Vis Sci 52:8295-9. 2011..Recently, IL-2 receptor alpha (IL2RA, also called CD25) and IL-7 receptor alpha (IL7RA) gene variants (rs2104286, rs12722489, and rs6897932) have been identified to play ..
- Genome-wide association study in alopecia areata implicates both innate and adaptive immunityLynn Petukhova
Department of Dermatology, Columbia University, New York, New York 10032, USA
Nature 466:113-7. 2010..cells), cytotoxic T lymphocyte-associated antigen 4 (CTLA4), interleukin (IL)-2/IL-21, IL-2 receptor A (IL-2RA; CD25) and Eos (also known as Ikaros family zinc finger 4; IKZF4), as well as the human leukocyte antigen (HLA) region...
- Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA'sM Hatakeyama
Institute for Molecular and Cellular Biology, Osaka University, Japan
Science 244:551-6. 1989Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain...
- IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D)Antonio Alcina
Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Granada, Spain
PLoS ONE 4:e4137. 2009IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity.
- IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor productionLisa M Maier
Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 5:e1000322. 2009..We demonstrate that multiple variants independently correlate with sIL-2RA levels...
- Binding of HMG-I(Y) imparts architectural specificity to a positioned nucleosome on the promoter of the human interleukin-2 receptor alpha geneR Reeves
Biochemistry Biophysics, School of Molecular Biosciences, Washington State University, Pullman 99164, USA
Mol Cell Biol 20:4666-79. 2000..Together, these findings suggest a role for the HMG-I(Y) protein in assisting the remodeling of a critically positioned nucleosome on the PRRII promoter element during IL-2Ralpha transcriptional activation in lymphocytes in vivo...
- Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel diseaseAna Marquez
Immunology Department, Hospital Clinico San Carlos, Madrid 28040, Spain
Am J Gastroenterol 104:1968-75. 2009..Therefore, we decide to investigate the association of polymorphisms in the IL-2 axis (IL2, IL2RA, and IL2RB genes) with inflammatory bowel diseases (IBDs)...
- Toward further mapping of the association between the IL2RA locus and type 1 diabetesHui Qi Qu
Endocrine Genetics Laboratory, McGill University Health Center Montreal Children s Hospital, Montreal, Quebec, Canada
Diabetes 56:1174-6. 2007....
- Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitisEdward J Carr
Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0XY, UK
BMC Med Genet 10:22. 2009....
- Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosusMichael Bonelli
Division of Rheumatology, Internal Medicine III, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria
J Immunol 182:1689-95. 2009CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) that specialize in the suppression of immune responses might be critically involved in the pathogenesis of autoimmune diseases...
- Association of the IL2RA/CD25 gene with juvenile idiopathic arthritisAnne Hinks
University of Manchester, Manchester, UK
Arthritis Rheum 60:251-7. 2009IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide ..
- Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivoMilica Vukmanovic-Stejic
Department of Immunology and Molecular Pathology, Division of Infection and Immunity, Windeyer Institute of Medical Sciences, University College London, London, United Kingdom
J Clin Invest 116:2423-33. 2006..T lymphocytes were highly proliferative, with a doubling time of 8 days, compared with memory CD4+ CD45RO+ Foxp3- CD25- (24 days) or naive CD4+ CD45RA+ Foxp3- CD25- populations (199 days)...
- Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPsOliver J Brand
Department of Medicine, Division of Medical Sciences, Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
Clin Endocrinol (Oxf) 66:508-12. 2007..identified genetic association between type 1 diabetes (T1D) and the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region on chromosome 10p15...
- Altered interleukin-2 receptor alpha-chain is expressed in human T-cell leukaemia virus type-I-infected T-cell lines and human peripheral blood mononuclear cells of adult T-cell leukaemia patients through an alternative splicing mechanismS Horiuchi
Department of Microbiology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
Immunology 91:28-34. 1997..Our results indicate that an altered IL-2R alpha chain is expressed in HTLV-I-infected T lymphocytic cell lines and in ATL patients...
- Temporal and subunit-specific modulations of the Rel/NF-kappaB transcription factors through CD28 costimulationB Kahn-Perles
Unité de Cancérologie Expérimentale, U119 INSERM, 27 Boulevard Lei Roure, 13009 Marseille, France
J Biol Chem 272:21774-83. 1997..dependent on persistent autocrine secretion of interleukin 2 (IL-2), high and prolonged expression of inducible CD25/IL-2 receptor alpha chain (IL-2Ralpha), and secretion of growth factors such as the granulocyte-macrophage colony-..
- Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis riskMaría L Cavanillas
Immunology Department, Hospital Clinico San Carlos, Madrid, Spain
Eur J Hum Genet 18:794-9. 2010..The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation...
- Soluble interleukin-2 receptor in cancerSaburo Murakami
Department of Surgery, Saitama Medical School, Morohongo 38, Moyorama machi, Iruma gunn, Saitama, 350 0495, Japan
Front Biosci 9:3085-90. 2004..Serum sIL-2R is a useful parameter for evaluating the disease stage and monitoring the disease progression during the post-treatment follow-up, though it is not an organ-specific parameter...
- Levels of circulating regulatory CD4+CD25+ T cells are decreased in breast cancer patients after vaccination with a HER2/neu peptide (E75) and GM-CSF vaccineMatthew T Hueman
Clinical Breast Care Project, Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
Breast Cancer Res Treat 98:17-29. 2006..We have investigated the impact of this vaccine on circulating levels of regulatory T cells (Treg) and the resulting effects on antitumor responses...
- IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populationsF Weber
Max Planck Institute of Psychiatry, Munich, Germany
Genes Immun 9:259-63. 2008..1 to 1.5. The discovery and validation of new genetic risk factors in independent populations may help toward the understanding of MS pathogenesis by providing valuable information on biological pathways to be investigated...
- In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cellsM Algarte
INSERM U119, Marseille, France
EMBO J 14:5060-72. 1995..b>CD25/IL-2R alpha can be efficiently induced in primary human T cells since approximately 100% express this gene when ..
- Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteinsS John
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892
Mol Cell Biol 15:1786-96. 1995....
- A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?Thea G A Strieder
Academic Medical Center, University of Amsterdam, Department of Endocrinology, 1105 AZ, Amsterdam Zuidoost, The Netherlands
Autoimmunity 39:93-8. 2006..subsets of activated (MHC class-II, CD25 (IL-2R), CD71 or CD69+) CD4+ T cells and the level of the soluble (s)-IL2R in serum...
- Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain geneB B Lin
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
Mol Cell Biol 10:850-3. 1990..Thus, it is possible that both positive and negative elements may be important in the regulation of IL-2R alpha gene transcription...
- Structure of the human interleukin-2 receptor geneW J Leonard
Science 230:633-9. 1985..Receptor gene transcription is initiated at two principal sites in normal activated T cells. Adult T cell leukemia cells infected with HTLV-I show activity at both of these sites, but also at a third transcription initiation site...
- IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibilityFuencisla Matesanz
J Neurol 254:682-4. 2007
- Both integrated and differential regulation of components of the IL-2/IL-2 receptor systemHyoung Pyo Kim
Laboratory of Molecular Immunology, Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, United States
Cytokine Growth Factor Rev 17:349-66. 2006..We now cover an under-reviewed area-the regulation of genes encoding IL-2 and IL-2R components, with an effort to integrate/explain this knowledge...
- Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphismsAdrian Vella
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Addenbrooke s Hospital, Cambridge, United Kingdom
Am J Hum Genet 76:773-9. 2005..associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the biological candidate gene IL2RA (CD25), which encodes a subunit (IL-2R alpha) of the high-affinity interleukin-2 (IL-2) receptor complex...
- Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetesChristopher E Lowe
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, UK
Nat Genet 39:1074-82. 2007..635). Furthermore, we have associated IL2RA T1D susceptibility genotypes with lower circulating levels of the biomarker, soluble IL-2RA (P = 6.28 x 10(-28)), suggesting that an inherited lower immune responsiveness predisposes to T1D...
- Modulating effects on CD25 and CD71 antigen expression by lectin-stimulated T lymphocytes in the elderlyS Antonaci
University of Bari Medical Faculty, Italy
Immunopharmacol Immunotoxicol 13:87-100. 1991..aged peripheral blood mononuclear cells (PBMC) were stimulated with phytohemagglutinin (PHA) and assessed for CD25 (IL-2 receptor) and CD71 (transferrin receptor) expression at different intervals of time...
- Halothane inhibits T cell proliferation and interleukin-2 receptor expression in ratsJ G Hamra
Department of Anesthesiology, University of California, San Diego, LaJolla 92093-0818, USA
Immunopharmacol Immunotoxicol 18:323-36. 1996..The ability of T lymphocytes to express both the CD8 and CD25 (IL-2) receptors in response to PHA were suppressed...
- Immunohistochemical demonstration of subclasses of inflammatory cells and active, collagen-producing fibroblasts in the synovial plicae of lumbar facet jointsY T Konttinen
Fourth Department of Medicine, University of Helsinki, Central Hospital, Finland
Spine (Phila Pa 1976) 15:387-90. 1990....
- Defective expression of IL-2 receptors on peripheral blood lymphocytes from patients with cluster headacheP Martelletti
Headache Centre, , Rome, Italy
Headache 30:228-31. 1990..ml) and after 72 hours. The following Becton Dickinson MAbs have been used: anti-Leu-4 (CD3), anti-IL-2 receptors (CD25), anti-Transferrin receptor (TFR) and anti-Leu-11b (CD16)...
- [The serum level of the secreted interleukin 2 receptor (sIL-2R): a lymphocyte activity parameter in sarcoidosis]J Muller-Quernheim
III Med Klinik Schwerpunkt Pneumologie, Universitätskliniken Mainz
Pneumologie 44:213-4. 1990....
- [Monitoring sarcoidosis therapy with immunopathologic parameters]J Muller-Quernheim
III Med Klinik, Schwerpunkt Pneumologie, Johannes Gutenberg Universitat, Mainz
Pneumologie 48:47-9. 1994..Bronchoalveolar lavage yields different cytological patterns typical for the acute and chronic forms of the disease permitting the identification of the subpopulation on risk for functional deterioration...
- [Serum adenosine deaminase as a parameter for activity in sarcoidosis]E Wetzel
Krankenanstalt, , Akademisches Lehrkrankenhaus,
Pneumologie 53:323-8. 1999..In comparison to the other parameters, measurement of the serum ADA indicates a greater discrimination between active and inactive disease...
- Peripheral blood and tumor infiltrating lymphocytes in non-small cell lung cancer: analysis at the population and clonal levelM Viale
Istituto Nazionale per la Ricerca sul Cancro, Laboratorio di Farmacologia, Genova, Italy
Tumori 76:488-94. 1990..Differences were found in the expression of CD25 (IL-2 receptor) and DR (MHC class II) antigens, which were increased in TILs, and in the percentage of CD16+ ..
- Evaluation of cellular immune responses and soluble mediators in patients with chronic hepatitis C virus (cHCV) infectionE Jirillo
Faculty of Medicine, University of Bari, Italy
Immunopharmacol Immunotoxicol 17:347-64. 1995..In conclusion, the overall results indicate a condition of peripheral immune depression in cHCV patients with an exaggerated shedding of various mediators endowed with noxious effects for the host...
- Serum levels of interleukins 2, 6 and 8, soluble interleukin-2 receptor and intercellular adhesion molecule-1 during treatment with interleukin-2 plus interferon-alfaM S Vuoristo
Department of Oncology, Tampere University Hospital, Finland
Immunopharmacol Immunotoxicol 18:337-54. 1996..Thus, no definite conclusions could be drawn. However, it seems worthwhile to measure IL-2, sIL-2R and sICAM-1 during immunotherapy; their prognostic value should be further evaluated in a larger patient population...
- Re-infection in human schistosomiasis mansoni: a prospective field study 18 months after praziquantel therapyK Zwingenberger
Ann Trop Med Parasitol 84:457-65. 1990..The results indicate a dissociation of factors regulating fibrogenesis and immunomodulation after treatment and re-infected...
- Circulating soluble IL-2 receptor levels are low in patients with hypothyroid autoimmune thyroiditisA Loviselli
Institute of Internal Medicine, University of Cagliari, Italy
Horm Metab Res 26:548-51. 1994..They also suggest that the measurement of soluble Interleukin 2 receptors could be used as a marker of the peripheral action of thyroid hormones...
- Garlic extracts stimulate proliferation of rat lymphocytes in vitro by increasing IL-2 and IL-4 productionM Colic
Institute of Medical Research, Military Medical Academy, Belgrade, Yugoslavia
Immunopharmacol Immunotoxicol 22:163-81. 2000..These results suggest that the potentiating effect of garlic extracts on lymphocyte proliferation in vitro differs depending on specific stimulators of cell proliferation and probably on the type of responding cells...
- Immunotoxicity of cocaethyleneF Chiappelli
Laboratory of Human Oral and Molecular Immunology, UCLA School of Dentistry 90024-1668, USA
Immunopharmacol Immunotoxicol 17:399-417. 1995....
- Analysis of interleukin-2/interleukin-2 receptor system in advanced non-small-cell lung cancerF De Vita
Department of Internal and Experimental Medicine F. Magrassi, II University of Naples, Italy
Tumori 84:33-8. 1998..Circulating CD25+ cells were analyzed by flow cytoflorimetry...
- [Study on cellular immunity in children with respiratory syncytial virus associated acute lower respiratory infection]Z Chen
Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan 430030
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:263-6. 1997..These results suggested that human body had a functional disturbance in cellular immunity when infected with RSV...
- Increased level of soluble interleukin-2 receptor in advanced solid tumors: a preliminary studyF Rovelli
Laboratorio di Radioimmunologia, Ospedale San Gerardo, Milano, Italia
Tumori 74:633-7. 1988..Further studies will be needed to establish if elevated concentrations of IL-2R in the serum can contribute to the immunoincompetence of patients with disseminated solid neoplasms...
- Modulation of the interleukin 2 receptor by maternal and cord blood serumY E Vanderbeeken
Department of Immunology, Hospital St-Pierre, Brussels, Belgium
Immunopharmacol Immunotoxicol 12:211-36. 1990..inhibitive action, of maternal serum (retroplacental and peripheral), and cord blood serum on the expression of the Il2r has been studied. Calf and male serum were used as a control...
- Interleukin-2 receptor levels in non-Hodgkin's lymphoma. Correlation to histological degree of malignancy and presence of constitutional symptomsJ M Tangen
Department of Oncology, , Oslo, Norway
Acta Oncol 29:581-3. 1990..All three parameters should therefore be taken into account when the clinical significance of Il-2R levels is evaluated...
- Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble interleukin-2 receptor, prolactin and cortisolM Maes
CRC-MH, Department of Psychiatry, AZ Stuivenberg, Antwerp, Belgium
Eur Arch Psychiatry Clin Neurosci 245:172-8. 1995..There were also significant positive correlations between plasma prolactin and sIL-2R concentrations in major depressed subjects and in the combined groups of normal and major depressed subjects...
- Soluble interleukin-2 receptor levels in patients with malignant melanoma and renal cell cancerB Ostenstad
Institute of Immunology and Rheumatology, Oslo, Norway
Acta Oncol 31:413-5. 1992..sIL-2R is possibly a marker of the host immune response to the tumour, but further investigations are needed to see if it has any predictive value concerning prognosis or response to immune therapy...
- Serum soluble interleukin-2 receptor in colorectal cancerS Murakami
Second Department of Surgery, Saitama Medical School, Japan
Acta Oncol 33:19-21. 1994..Preoperative serum IL-2R levels thus seem to reflect the stage of the disease...
- Mitoxantrone as a single agent in pretreated metastatic breast cancer: effects on T lymphocyte subsets and their relation to clinical responseS Barni
Divisione di Radioterapia Oncologica, Ospedale San Gerardo, Monza, Milano, Italy
Tumori 77:227-31. 1991..T suppressor cells (CD8+/CD57+), T cytotoxic cells (CD8+/CD57-), NK (CD16) and IL-2 receptor-expressing cells (CD25) were also measured at the same time...
- Sodium arsenite reduces proliferation of human activated T-cells by inhibition of the secretion of interleukin-2L Vega
, UNAM, ,
Immunopharmacol Immunotoxicol 21:203-20. 1999..In order to understand the mechanism of this suppression, the effect of As was evaluated on the expression of CD25, and IL-2 secretion in human peripheral blood mononuclear cells (PBMC)...
- Possible correlation between some biologic effects and the clinical course in patients treated with continuous infusion of interleukin-2 plus alpha-2 interferon for metastatic renal cell carcinomaC Baiocchi
Divisioni Oncologia Medica Falck, , Milano, Italy
Tumori 80:348-52. 1994..Some of our patients showed a significant increase in eosinophils, CD25+ lymphocytes and antithyroid antibodies...
- Immunological alterations associated with Plasmodium vivax malaria in South KoreaH K Lee
Department of Clinical Pathology, College of Medicine, Catholic University of Korea, 62 Youido dong, Youngdeungpo gu, Seoul, 150 713, South Korea
Ann Trop Med Parasitol 95:31-9. 2001..e. CD3+, CD8+, CD19+, CD56+, CD3-/CD56+ and CD8+/CD56+ but not CD4+, CD3+/CD56+ or CD25+] were significantly less common among the lymphocytes of patients at diagnosis than among those of the controls...
- Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using lowB Hausen
Transplantation Immunology, Department of Cardiothoracic Surgery, Stanford University, Palo Alto, California 94305, USA
Transplantation 69:488-96. 2000..CsA and high-dose SDZ RAD (CTL group) to triple therapy using the chimeric anti-interleukin-2 (IL-2) receptor (CD25) monoclonal antibody (mAb) basiliximab (anti-IL-2 receptor mAb) for induction therapy (basiliximab: 5 mg ..
- Successful in vivo blockade of CD25 (high-affinity interleukin 2 receptor) on T cells by administration of humanized anti-Tac antibody to patients with psoriasisJ G Krueger
Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10021 6399, USA
J Am Acad Dermatol 43:448-58. 2000Daclizumab is a humanized antibody to the alpha-subunit (CD25) of the interleukin 2 (IL-2) receptor that blocks normal IL-2 binding to this receptor...
- Comparison of the prevalence of inflammatory cells in subtypes of disc herniations and associations with straight leg raisingJ Virri
Department of Orthopaedics, University of Helsinki, Finland
Spine (Phila Pa 1976) 26:2311-5. 2001..Monoclonal antibodies to T cells in general (CD2), activated T cells (CD25), B cells (CD22), and macrophages (CD68) were used...
- Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesS Sakaguchi
Precursory Research for Embryonic Science and Technology PRESTO, Research and Development Corporation of Japan JRDC, Tsukuba Life Science Center
J Immunol 155:1151-64. 1995..CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules...
- Functional responses of T cells blocked by anti-CD25 antibody therapy during cardiac rejectionC C Baan
Department of Internal Medicine I, University Hospital Rotterdam Dijkzigt, The Netherlands
Transplantation 69:331-6. 2000Despite anti-CD25 (interleukin [IL]-2 receptor alpha chain) monoclonal antibody (mAb) therapy, rejection can still occur...
- [Expression of regulatory T cells and related cytokines in mice allogenic corneal transplantation rejection]Xin Wang
Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, China
Zhonghua Yan Ke Za Zhi 45:1118-26. 2009To study the changes of CD4(+)CD25(+) and CD8(+)CD103(+) regulatory T cells and their relevant cytokines in corneal allograft transplantation in mice.
- Generation of Affibody ligands binding interleukin-2 receptor alpha/CD25Caroline Grönwall
Department of Molecular Biotechnology, School of Biotechnology, AlbaNova University Center, Royal Institute of Technology KTH, SE 106 91 Stockholm, Sweden
Biotechnol Appl Biochem 50:97-112. 2008Affibody molecules specific for human IL-2Ralpha, the IL-2 (interleukin-2) receptor alpha subunit, also known as CD25, were selected by phage-display technology from a combinatorial protein library based on the 58-residue Protein A-..
- Dysregulated expression of CD69 and IL-2 receptor alpha and beta chains on CD8+ T lymphocytes in flaky skin miceN J Abernethy
Genesis Research and Development Corporation Limited, Auckland, New Zealand
Immunol Cell Biol 78:596-602. 2000..the present study, the expression of the inducible T-cell activation antigens CD69 and IL-2 receptor alpha chain (CD25) on PLN cells from fsn/fsn mice and their phenotypically normal littermates is examined...
- Immunohistochemical assessment of CD25 is equally sensitive and diagnostic in mastocytosis compared to flow cytometryC Baumgartner
Medical University of Vienna, Vienna, Austria
Eur J Clin Invest 38:326-35. 2008..In most cases, the bone marrow is involved. Expression of CD25 in bone marrow MC, with or without coexpression of CD2, is an important minor SM criterion...
- Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and rapamycin in xenogeneic islet transplantationH Pan
Department of General Surgery West China Hospital, Si Chuan University, Chengdu, Sichuan, China
Transplant Proc 39:3452-4. 2007..The aim of this study was to investigate whether classical anergy and/or regulation by interleukin (IL)2-dependent CD25+ T regulatory cells played roles in the induction and maintenance of tolerance in this model.
- [Changes of regulatory T cell number in hepatocellular carcinoma-bearing mice and its relationship with tumor growth]Pin Zhang
Institute of Immunology, Medical School of Shandong University, Jinan 250012, China
Zhonghua Zhong Liu Za Zhi 29:342-5. 2007..To study the relationship between the change of regulatory T cell number in CD4+ T subset and the growth of tumor in H22 hepatocellular carcinoma-bearing mice...
- Interleukin-2 blocks the antitumour activity caused by depletion of CD25 cells in a murine renal adenocarcinoma modelTakumi Takeuchi
Department of Urology, Faculty of Medicine, University of Tokyo, Japan
BJU Int 94:171-6. 2004To test the effectiveness of antimouse CD25 monoclonal antibody (mAb) against murine renal adenocarcinoma (RENCA) cells, as immunoregulatory/suppressor cells are known to be involved in tumour development in vivo, but the functions of ..
- Adoptive transfusion of ex vivo donor alloantigen-stimulated CD4(+)CD25(+) regulatory T cells ameliorates rejection of DA-to-Lewis rat liver transplantationLi Yong Pu
Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Surgery 142:67-73. 2007..In this study, we examined the therapeutic potential of CD4(+)CD25(+) Treg cells in a naive rejection model of rat liver transplantation.
- Mechanism of action of maternal serum on the interleukin2 receptor expressionY E Vanderbeeken
Service d'Immunologie, , Brussels, Belgium
Immunopharmacol Immunotoxicol 14:491-513. 1992..The Il2R expression was significantly downregulated among maternal serum treated cells...
- Immunosuppression for neural xenografts: a comparison of cyclosporin and anti-CD25 monoclonal antibodyC R Honey
Division of Neurosurgery, University of British Columbia, Vancouver, Canada
J Neurosurg 91:109-13. 1999..was to compare the effects of short- and long-term immunosuppression induced by cyclosporin with those of immunosuppression induced by a monoclonal antibody against the rat interleukin-2 receptor (anti-CD25 mAb) in rats with xenografts.
- Induction of inducible CD4+CD25+Foxp3+ regulatory T lymphocytes by porcine reproductive and respiratory syndrome virus (PRRSV)P Wongyanin
Interdisciplinary Program of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand
Vet Immunol Immunopathol 133:170-82. 2010..Recently, the existence of porcine CD4(+)CD25(+) Tregs has been demonstrated. We investigated the effect of PRRSV on the CD4(+)CD25(+) Tregs...
- [Inhibition of CD4+ CD25+ regulatory T cells in chronic hepatitis B patients]Heng Hui Zhang
Hepatology Institute, People s Hospital, Peking University, Beijing, China
Zhonghua Yi Xue Za Zhi 88:511-5. 2008To evaluate the inhibition of CD4+ CD25+ regulatory T cells (Treg) in the chronic hepatitis B patients.
- [Effect of apoptosis of CD4+ CD25+ regulatory T lymphocytes on polarization of helper T lymphocytes and potential interventional influence of Xuebijing injection in septic rats]Xin gui Dai
Intensive Care Unit, Xiangya Hospital of Central South University, Changsha 410008, Hunan, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:135-8. 2009To evaluate the influence of apoptosis of CD4(+)CD25(+) regulatory T lymphocyte (Treg) on polarization of helper T lymphocyte (Th) and effect of Xuebijing injection in septic rats.
- Impact of CD4+CD25high regulatory T-cells and FoxP3 expression in the peripheral blood of patients with systemic lupus erythematosusMaha Atfy
Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt
Egypt J Immunol 16:117-26. 2009..Regulatory T cells (Tregs) CD4+CD25+ play an important role in maintaining tolerance to self-antigens controlling occurrence of autoimmune diseases...
- CD4+CD25+ regulatory T lymphocytes in malignant pleural effusionYi Qiang Chen
Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, P R China
Am J Respir Crit Care Med 172:1434-9. 2005Active suppression by CD4(+)CD25(+) regulatory T lymphocytes plays an important role in the downregulation of T-cell responses to foreign and self-antigens.
- Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4+CD25- T lymphocytesEmilie Brillard
INSERM U645, University of Franche Comte, EFS Bourgogne Franche Comte, Besancon, France
Exp Hematol 35:416-25. 2007CD4(+)CD25(+) regulatory T lymphocytes (Treg) have been initially shown to prevent organ-specific autoimmunity. It is now accepted that Treg homeostasis depends in part on the peripheral conversion of naïve CD4(+)CD25(-) T cells...
- Simultaneous blockade of costimulatory signals CD28-CD80 and CD40-CD154 combined with monoclonal antibody against CD25 induced a stable chimerism and tolerance without graft-versus-host disease in ratZ X Zhu
Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, Shanghai, PR China
Eur Surg Res 46:109-17. 2011..Our aim was to explore a nontoxic strategy for the induction of mixed chimerism by pretreatment with anti-CD25 monoclonal antibody (mAb), cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin (CTLA4Ig) and anti-CD154 mAb.
- Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosaSuzana Radulovic
Department of Upper Respiratory Medicine, Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital London, London, United Kingdom
J Allergy Clin Immunol 121:1467-72, 1472.e1. 2008Regulatory T (Treg) cells play an important role in controlling allergic inflammation. The transcription factor Foxp3 regulates the development and function of natural and adaptive CD4(+)CD25(+) Treg cells.
- Functional role of CD4+CD25+ regulatory T cells and transforming growth factor-beta1 in childhood immune thrombocytopenic purpuraNehal M A Fahim
Department of Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Egypt J Immunol 13:173-87. 2006CD4+CD25+ regulatory T cells (Tregs) are critical in maintaining self tolerance and preventing organ specific autoimmune diseases...
- Regulation of transplant arteriosclerosis by CD25+CD4+ T cells generated to alloantigen in vivoGregor Warnecke
Transplantation Research Immunology Group, Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford, UK
Transplantation 83:1459-65. 2007b>CD25+CD4+ regulatory T cells have been shown to suppress alloimmunity in various experimental settings. Here, we hypothesized that alloantigen-reactive regulatory T cells would reduce the severity of transplant arteriosclerosis.
- Role for CD4(+)CD25(+) T cells in inhibition of graft rejection by extracorporeal photopheresisJames F George
Department of Surgery, University of Alabama at Birmingham, AL 35294, USA
J Heart Lung Transplant 27:616-22. 2008..We created a mouse model of ECP to determine the effects of ECP on T-cell responses in vivo and the contribution of CD4(+)CD25(+) T cells.
- Nebraska/Kansas Blood and Marrow Transplant Research NetworkJULIE MARIE VOSE; Fiscal Year: 2013..The BMT/CTN including our consortium will be the only clinical cooperative group to accomplish this goal. ..
- The IL-2 receptor in T regulatory cell developmentThomas R Malek; Fiscal Year: 2012..It is now appreciated that signaling through IL2R is mandatory for Treg cells...
- Role of MEK1 in T cell function in asthmaRafeul Alam; Fiscal Year: 2013..We will examine genetically modified mouse strains and/or T cells, and an anti-IL2 receptor (anti-CD25) antibody for their effect on airway hyperreactivity, inflammation, mucus production and airway remodeling in this ..
- Homing and Homeostasis of Regulatory T cellsDaniel J Campbell; Fiscal Year: 2012..TR were initially identified by their constitutive expression of the high affinity IL-2 receptor component CD25, and IL-2 is required for proper TR function in vivo...
- Cytokines in T Regulatory Cell FunctionJames W Verbsky; Fiscal Year: 2013..We have shown that a patient lacking CD25, the high affinity IL-2 receptor, exhibits an autoimmune disease similar to patients lacking Foxp3...
- T1D:Investigating the Gut Microbiome, Urinary Proteome and MetabolomeRamana Madupu; Fiscal Year: 2011..We propose to study the complex interplay of environmental, immunological and genetic factors to discover molecular signatures with a potential to advance clinical diagnosis and therapy at or before the onset of T1D. ..
- Bridging Pediatric and Adult Biomarkers of Graft-Versus-Host-DiseaseJamie L Renbarger; Fiscal Year: 2013..Ultimately, we propose the discovery of a GVHD-specific drug to increase efficacy and lower toxicity. ..
- Development of Intestinal Immune Regulation in Human InfantsJOERN HENDRIK WEITKAMP; Fiscal Year: 2013..are professional immune suppressor cells that are typically characterized as interleukin-2 receptor a (IL-2Ra = CD25)''"3'''CD4^ CD45RO* IL-7R (CD127)*"'T cells expressing high levels of the ..
- Regulatory T Cell-Deficient Mouse Model Rapidly Develops Sjogren's SyndromeShyr Te Ju; Fiscal Year: 2010..This study should identify new and useful models for Sjogren's syndrome research. It should identify new mechanism(s) for the pathogenesis of the disease and provide potential treatment of the disease. ..
- IMMUNOREGULATION OF ERYTHROPOIESISLee Levitt; Fiscal Year: 1992..activity (BPA) from resting T cell and NK cells A 70KD IL2R has been identified in the absence of Tac antigen on resting T and NK cells. GM-CSF and IL3 have potent BPA...
- DESIGN OF MULTIMERIC INTERLEUKIN-2 RECEPTOR ECTODOMAINSThomas Ciardelli; Fiscal Year: 2000..4. To obtain detailed structure-activity data on these complexes by co-crystallizing them with IL-2 and determining their X-ray structures to high resolution. ..
- REGULATORY MECHANISMS IN HUMAN NATURAL CYTOTOXICITYTakashi Makinodan; Fiscal Year: 1990..This results in (a) increased IL2 receptor (IL2R) affinity and/or increased numbers of IL2R/ cell and/or increased numbers of cells with IL2R; and (b) increased IL2 ..
- ROLE OF IL2 RECEPTOR POSITIVE CELLS IN TRANSPLANTATIONNicholas Tilney; Fiscal Year: 1991..The role of activated leukocytes developing receptors for interleukin 2 (IL2R+ cells) in rejection will be emphasized, and their modulation by various IL2R targeted therapies assessed, a novel ..
- SPOTTED FEVER RICKETTSIAL ANTIGENSDavid H Walker; Fiscal Year: 2013..by remarkable suppression of lymphocyte proliferation and IL-2 and IFN-gamma production by IL-10 producing CD4+CD25+ T regulatory cells in acute fatal murine spotted fever rickettsiosis compared to self-limited infection...
- Phase-I-II Study of DAB389 (ONTAK) in Patients with Adv. Refractory Breast CancerLupe Salazar; Fiscal Year: 2007..to direct the cytocidal action of DT to malignant cells that express the high affinity form of the IL-2 receptor (CD25) while minimizing damage to normal cells that do not express the receptor...
- Therapeutic immune mechanisms of daclizumab in psoriasisJames Krueger; Fiscal Year: 2004..b>CD25 is the a-subunit of the IL-2R that is expressed selectively on activated T cells and dendritic antigen presenting ..
- Biology and Function of anti-HSV CD8 T CellsStephen Jennings; Fiscal Year: 2007..ability to express CTL function was intimately linked with the increased expression of the IL-2 receptor c_-chain, CD25. This observation lead to the conclusion that expression of high levels of CD25 was mandatory for the expression of ..
- Immunity to Ehrlichial InfectionsNagaraja Ramavadhani Thirumalapura; Fiscal Year: 2013..Further the study indicated that persistent E. muris infection induces expansion of CD4+CD25+ T regulatory cells and enhanced production of TGF-[unreadable]1 in the spleen, which may facilitate ehrlichial ..
- Characterization of Human Regulatory T cell-induced Dendritic CellsMICHAEL ALONSO; Fiscal Year: 2010DESCRIPTION (provided by applicant): CD4+CD25+Foxp3+ T regulatory cells (Tregs) and dendritic cells (DCs) are central to the immunosuppressive environment characteristic of many types of cancer including breast cancer...
- Immune Response to Cat: Regulatory and Effector T CellsJudith A Woodfolk; Fiscal Year: 2013..Low expression of CD127 (IL-7R 1 chain) will be used to isolate natural (CD25+CD127lo) and adaptive (CD25negCD127lo) Tregs from AD patients...
- Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat ModelGREGORY TODD PHARR; Fiscal Year: 2010..Treg cells will be identified in placental sections by immunofluorescent labeling with antibodies to CD4, CD25, and FoxP3. Confocal microscopy will be used to quantify these cells...
- Role of Memory T Cells in Pathogenesis and Resolution of Inflammatory DiseasesRichard B Bankert; Fiscal Year: 2010..nasal polyp tissues expand progressively following their implantation into severely immunocompromised NOD/SCID/IL2Rγnull mice, the contributions of lymphocytes and monocytes (and the biologically active factors they ..
- Interleukin-2 and autoimmune diseaseAbul K Abbas; Fiscal Year: 2012..immune dysregulation and systemic autoimmunity because the obligatory function of this cytokine is to maintain CD4+ CD25+ FoxP3+ regulatory T-lymphocytes (Treg)...
- Control of Treg Homeostasis and Function by the Lipid Phosphatase PTENLaurence A Turka; Fiscal Year: 2013..Surprisingly, although these mice have elevated numbers of Tregs, a high proportion of those cells are CD25- and CD62Llo, and the animals develop a severe polyclonal lymphoproliferative disorder...
- Pathophysiology of Adult T-cell Leukemia/LymphomaUTPAL P DAVE; Fiscal Year: 2013..infection, viral proteins expressed by HTLV-1, notably tax, transcriptionally activate expression of IL2 and IL2R genes resulting in lymphoproliferation by autocrine signaling...
- Characterization of a novel T cell activating protein in arthritisRaphael Hirsch; Fiscal Year: 2013..Furthermore, FSTL-1 prolongs expression of the T cell activation molecule, CD25. To characterize the T cell activating properties of FSTL-1, we will determine the T cell activation phenotype ..
- Perfluorooctane Sulfonate (PFOS) affects 1gM Production via IL-2Margie M Peden Adams; Fiscal Year: 2010..suppresses antibody production via altered T-cell IL-2 production but not macrophage cytokine production or altered CD25, CD27, or CD70 expression. Aim 1...
- S. aureus and Regulatory T cells in the Failure of Oral ToleranceAnne Marie Singh; Fiscal Year: 2013..aureus plays a crucial role in the cutaneous inflammation of atopic eczema and activation of CD25+ Treg cells with S. aureus enterotoxin B (SEB) abrogated their suppressive phenotype...
- Immunization against AtherosclerosisGuoxing Zheng; Fiscal Year: 2012..Importantly, CD4+CD25+Foxp3+ regulatory T cells (Treg), a subset of T cells that function to suppress the response of Teff, have been ..
- Transfusion-associated immune hemolysisKarina Yazdanbakhsh; Fiscal Year: 2010..Increasing evidence indicates that CD4+ regulatory T cells (Tregs) characterized by co- expression of CD25 and the forkhead/winged helix transcription factor(Foxp3) are key suppressors of immunopathological immune ..
- Selective MicoRNA modification to enhance regulatory T cell function in IBDColm Collins; Fiscal Year: 2013..e. TNF[unreadable]ARE) that recapitulates many features of Crohn's disease;demonstrated expansion of CD4+CD25+Foxp3+ regulatory T cells (Tregs) in the inflamed ileum along the disease timecourse by both flow cytometry and RT-..
- Purification &Characterization of Adenosine ReceptorsJoel M Linden; Fiscal Year: 2009..Possible targets of AaA agonists are CD4+ T effector cells (CD25-) NKT cells, antigen presenting cells (including macrophages and dendritic cells) and T regulatory cells (CD25+)...
- Estrogen and Immunoprotection in Experimental StrokePatricia D Hurn; Fiscal Year: 2013..to abnormal activation of splenic immunocytes, particularly T lymphocytes that have a regulatory phenotype (CD4+CD25+FoxP3+ Treg cells) and ordinarily provide endogenous immunosuppression...
- T regulatory cell suppression of CD8+ cell responses during FIV InfectionJONATHAN FOGLE; Fiscal Year: 2012..dysfunction is the result of "clonal anergy" induced by membrane-bound TGF-beta (mTGF-beta) on virus activated CD4+CD25+ T reg cells that engage TGF-betaRII on the target cell...
- Immunoregulation and immunotherapy of breast cancerRobert H Vonderheide; Fiscal Year: 2012..a novel vaccine against the human telomerase reverse transcriptase (hTERT) and survivin in combination with anti-CD25 antibody daclizumab in patients with hormone receptor positive (HR+) metastatic disease...
- Role of Regulatory T Cells in Chronic Obstructive Pulmonary DiseaseWissam M Chatila; Fiscal Year: 2012..nonsmokers), by isolating CD4+CD25hi cells from the peripheral blood of subjects and performing conventional CD4+CD25- and CD8+ proliferative and cytokine production assays;3) to determine the effect of smoking on Treg cell function ..
- ASTHMA AND ALLERGIC DISEASE CENTERThomas A Platts Mills; Fiscal Year: 2010..Project 2: CD25+CD4+ T cells and IgE-mediated disease in humans: The phenotype and function of a novel CD25+CD4+ subset associated ..
- CD4 aptamer-siRNA chimeras to prevent HIV transmissionJudy Lieberman; Fiscal Year: 2013..Preliminary data obtained after intravaginal application of CD4 aptamer-siRNA chimeras in NOD/scid/IL2R?-/- mice reconstituted with human bone marrow, fetal liver and thymus (BLT mice) show both uptake of Cy3-labeled ..
- T Regulatory Cells in HIV InfectionDouglas F Nixon; Fiscal Year: 2010The overall aim of this study is to determine the phenotype, function, and role of CD4+CD25+ regulatory T cells (Treg cells) in HIV infected and uninfected humans...
- KLF10, T regulatory cells, and atherogenesisMark W Feinberg; Fiscal Year: 2012..Recent studies have shown a critical role for CD4+CD25+ T regulatory cells for inhibiting the progression of atherosclerosis, an effect dependent in part on TGF-2 ..
- The immunobiology of CD4+ CD25+ T regulatory cellsThomas R Malek; Fiscal Year: 2013..Understanding the factors that reverse autoimmunity in the IL-2Rb- deficient model may also provide new information concerning the etiology and potential therapy that may be generally common to several human autoimmune diseases. ..
- A Novel Therapy for Restricted Induction of Tolerance to Treat Diabetes MellitusKanneganti Murthy; Fiscal Year: 2013..may result from excess pathogenic Th1/Th17 cells and deficient tolerance-inducing antigen (Ag)-specific Treg (FOXp3+CD25+) and Tr1 CD4+ cells (FOXp3-CD25- IL-10high)...
- H. Pylori infection and manipulation of the host inflammatory responseVICTORIA ELIZABETH RUIZ; Fiscal Year: 2010..pylori infection. The second aim is to elucidate the role of CD4+CD25+Foxp3+ regulatory T-lymphocytes during chronic H...
- Blood Stem Cell Transplantation as ImmunotherapySamuel Strober; Fiscal Year: 2013..S. Negrin, Leader) will perform additional preclinical studies that elucidate the function of donor CD4+CD25+ Treg cells and show how they can be used more effectively to prevent GVHD while maintaining graft anti-tumor (GVT) ..
- Role of Dendritic Cells in H pylori-induced Treg-mediated Host Immune ToleranceJohn Y Kao; Fiscal Year: 2013..pylori-stimulated BMDCs into mice to induce H. pylori- specific Tregs and then use CD25 neutralizing antibodies to study the effect of Treg depletion on H. pylori tolerance...
- An Immune Tolerance Strategy for Prevention and Treatment of AtherosclerosisJAYME contact BORENSZTAJN; Fiscal Year: 2011..indicates that tolerance induced by antigen-coupled cells is due, at least in part, to the up-regulation of CD4+CD25+FoxP3+ regulatory T cells (Tregs) that function in the suppression of pathogenic T cells...
- Immunology of Factor IX Gene Transfer to LiverRoland W Herzog; Fiscal Year: 2013..IX transgene product. Tolerance induction critically depended on a CD4+CD25+FoxP3+ regulatory T cell (Treg) response...
- Regulation of Foxp3 FunctionAndrew D Wells; Fiscal Year: 2012..Expression of Foxp3 initiates a unique transcriptional program which includes the induction of genes such as GITR, CD25, CTLA-4, IL-10 and TGF2, and repression of pro-inflammatory cytokine genes such as IL-2 and IFN?...
- T CELL RESPONSE TO MYELIN PROTEOLIPID PROTEINVijay K Kuchroo; Fiscal Year: 2013..the Fox-P3 transcription factor, we have generated a Foxp3- EGFP "knock-in" mouse strain in order to track CD4+ CD25+ Fox-P3+ Tregs by GFP-expression...
- Innate Regulation and CD4+Th1/17 Immunity in TMEV-Induced DemyelinationStephen D Miller; Fiscal Year: 2013..Employing depletion, supplementation and genetic approaches, Aim 1 will test the hypothesis that activation of CD4+CD25+Foxp3+ Tregs plays a major role in regulating susceptibility to TMEV-IDD by inhibiting development of virus-..
- GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTIONDAVID WILLIAM SCOTT; Fiscal Year: 2013..Importantly, we found that CD25+, FoxP3+ regulatory T cells were required for both the induction and maintenance of tolerance in this system...
- Lung Transplantation and Immune Tolerance in Young RecipientsRichard Nash; Fiscal Year: 2007..been further characterized and the findings are consistent with a peripheral mechanism involving regulatory (CD4+ CD25+) T cells...
- Novel Strategies for Cancer Immunotherapy in Stem Cell TransplantYiping Yang; Fiscal Year: 2013..production of immune inhibitory cytokines, and induction of tumor-specific T cell tolerance mediated by CD4+CD25+ regulatory T (TReg) cells...
- Treg Migration in GVHDJonathan Serody; Fiscal Year: 2009..The expansion of alloreactive T cells is controlled both by homeostatic proliferation and regulatory T cells. CD4+/CD25+ Treg cells have been shown to be capable of inhibiting GVHD in multiple different murine models and the expansion ..
- Integrin CD11b and its role in immune suppressionLi Zhang; Fiscal Year: 2010..including CD11b+CD11c- macrophages and CD11c+ dendritic cells (DC), and also on the formation of a distinct CD4+CD25+ T regulatory (Treg) cell population that expresses the transcription factor Foxp3...
- T Cell Homeostasis in Systemic AutoimmunityArgyrios N Theofilopoulos; Fiscal Year: 2012..receptor downregulation and their implications to autoimmunity by determining the dynamic regulation of CD127 and CD25, the downregulation of CD127 on chronically-activated transgenic CD4 T cells by the regulated expression of a ..
- APOPTOSIS OF SMOOTH MUSCLE CELLS IN CAROTID PLAQUESDevendra K Agrawal; Fiscal Year: 2013..Also, stronger immunoreactivity of Foxp3, IL-10 and CD25 with preponderance of CD4? T cells in carotid plaques of asymptomatic than symptomatic patients...
- BDNF-engineered stem cell mediated neuroprotection in EAESUHAYL S DHIB JALBUT; Fiscal Year: 2010..pathogenic T cells by suppressing production of proinflammatory cytokines and/or promoting differentiation of CD4+CD25+ regulatory T cells (Tregs)...
- Role of Novel T Cell Costimulatory Pathways in Allograft Rejection and ToleranceMohamed H Sayegh; Fiscal Year: 2011..preliminary data, that the TIM-1 :TIM-4 pathway may have an important role in the generation and/or function of CD4+CD25+ regulatory T cells in vivo...
- Immune mechanisms of CAM intervention in autoimmunityBRIAN CALVIN ASTRY; Fiscal Year: 2013..reduction of IL- 17 response is owing to an altered balance between CD4+ T helper 17 (Th17) and CD4+CD25+Foxp3+ T regulatory cells (Treg), which is influenced in part by altered processing and presentation of the disease-..
- IMMUNOREGULATION AND PATHOLOGY OF CHRONIC-RELAPSING EAEStephen D Miller; Fiscal Year: 2013..antigen representation (cross-tolerance) and induction of both clonal anergy and activation of antigen-specific CD4+CD25+ iTregs which together regulate both na[unreadable]ve and activated encephalitogenic Th1/17 cells...
- The Effect of Bromelain on CD4+ T Cell Function in AsthmaERIC RICHARD SECOR; Fiscal Year: 2012..We have observed that Br treatment reduces CD25, a key activation marker on CD4+ T cells as well as alters MHC-II and CD86 levels on antigen presenting cells (APCs)..
- Immunological Monitoring of Heart Allograft RecipientsNicole Suciu Foca; Fiscal Year: 2006..Daclizumab, a humanized anti-CD25 antibody has been added to conventional immunosuppression to block and delete alloreactive T cells which express ..
- Consequences of Aging on Immune Response and Transplant OutcomeSTEFAN GUNTHER TULLIUS; Fiscal Year: 2013..At the same time, we observed a well preserved suppressor function of old alloantigen-specific CD4+CD25+FoxP3+ T cells...
- IL-2-dependent mechanisms in T1DThomas R Malek; Fiscal Year: 2013..However, other than induction of Foxp3 and CD25, little is known concerning the mechanisms activated in Tregs by weak IL-2R signaling...
- Modulation of HIV-1 Replication and T Cell Activation by FoxP3Lishan Su; Fiscal Year: 2007Overt immune activation is associated with AIDS. Given their proven activity in suppressing immune responses, CD4+CD25+FoxP3+ Treg cells may play an important role in HIV-1 diseases progression; With the CD4 receptor and CCR5/CXCR4 ..
- Monoclonal Antibodies Against T-Regulatory CellsAlan Epstein; Fiscal Year: 2005..of a tumor targeting monoclonal antibody (TNT) and the human chemokine LEC (Liver-expressed chemokine, CCL16) and CD25+ T-regulatory cell depletion can produce complete and lasting cures of two solid tumor models of the BALB/c mouse...