CD244

Summary

Gene Symbol: CD244
Description: CD244 molecule
Alias: 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, natural killer cell receptor 2B4, CD244 molecule, natural killer cell receptor 2B4, NK cell activation inducing ligand NAIL, NK cell activation-inducing ligand, NK cell type I receptor protein 2B4, SLAM family member 4, h2B4, signaling lymphocytic activation molecule 4
Species: human

Top Publications

  1. ncbi 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function
    Jennifer Klem
    Department of Pathology and Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    J Immunol 169:55-62. 2002
  2. pmc Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes
    N M Valiante
    Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
    J Exp Med 178:1397-406. 1993
  3. pmc 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48
    M H Brown
    Medical Research Council Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Exp Med 188:2083-90. 1998
  4. ncbi Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
    S G Tangye
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA, USA
    J Immunol 162:6981-5. 1999
  5. ncbi Activating interactions in human NK cell recognition: the role of 2B4-CD48
    H Nakajima
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1676-83. 1999
  6. pmc X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells
    S Parolini
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Brescia, 25123 Brescia, Italy
    J Exp Med 192:337-46. 2000
  7. ncbi NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)
    C Watzl
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 165:3545-8. 2000
  8. ncbi 2B4-mediated activation of human natural killer cells
    S G Tangye
    Centenary Institute for Cancer Medicine and Cell Biology, Immune Relation Group, University of Sydney, Locked Bag 6, Newtown, NSW 2042, Sydney, Australia
    Mol Immunol 37:493-501. 2000
  9. pmc Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells
    M Morra
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 20:5840-52. 2001
  10. ncbi 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways
    S S Chuang
    Department of Molecular Biology and Immunology and Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Immunol 167:6210-6. 2001

Research Grants

Detail Information

Publications323 found, 100 shown here

  1. ncbi 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function
    Jennifer Klem
    Department of Pathology and Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    J Immunol 169:55-62. 2002
    b>2B4 is a receptor belonging to the Ig superfamily and is found on all murine NK cells as well as a small subset of T cells...
  2. pmc Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes
    N M Valiante
    Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
    J Exp Med 178:1397-406. 1993
    ..Taken as a whole, our results suggest that p38 may have a direct role in the recognition, signal transduction, and/or lytic mechanisms of non-MHC-restricted cytotoxicity...
  3. pmc 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48
    M H Brown
    Medical Research Council Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Exp Med 188:2083-90. 1998
    b>2B4 is a cell surface glycoprotein related to CD2 and implicated in the regulation of natural killer and T lymphocyte function...
  4. ncbi Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP
    S G Tangye
    Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA, USA
    J Immunol 162:6981-5. 1999
    ..SLAM exhibits homology with the mouse cell surface receptor 2B4. The human homologue of 2B4 has now been identified. It is recognized by the c1...
  5. ncbi Activating interactions in human NK cell recognition: the role of 2B4-CD48
    H Nakajima
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1676-83. 1999
    b>2B4 is a cell surface glycoprotein of the immunoglobulin superfamily structurally related to CD2-like molecules...
  6. pmc X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells
    S Parolini
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Brescia, 25123 Brescia, Italy
    J Exp Med 192:337-46. 2000
    b>2B4 is a surface molecule involved in activation of the natural killer (NK) cell-mediated cytotoxicity...
  7. ncbi NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)
    C Watzl
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 165:3545-8. 2000
    b>2B4 is an NK cell activation receptor that can provide a co-stimulatory signal to other activation receptors and whose mode of signal transduction is still unknown...
  8. ncbi 2B4-mediated activation of human natural killer cells
    S G Tangye
    Centenary Institute for Cancer Medicine and Cell Biology, Immune Relation Group, University of Sydney, Locked Bag 6, Newtown, NSW 2042, Sydney, Australia
    Mol Immunol 37:493-501. 2000
    b>2B4 is a member of the CD2 subset of the immunoglobulin superfamily of cell surface receptors. Other members of this family include CD2, CD48, CD58, CD84, signaling lymphocytic activation molecule and Ly-9...
  9. pmc Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells
    M Morra
    Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 20:5840-52. 2001
    ..EAT-2 binds to the phosphorylated receptors CD84, CD150, CD229 and CD244, and acts as a natural inhibitor, which interferes with the recruitment of the tyrosine phosphatase SHP-2...
  10. ncbi 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways
    S S Chuang
    Department of Molecular Biology and Immunology and Institute for Cancer Research, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    J Immunol 167:6210-6. 2001
    2B4 (CD244), a member of the CD2 subset of the Ig superfamily receptors, is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes...
  11. pmc Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors
    Riyan Chen
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Quebec, Canada
    Mol Cell Biol 24:5144-56. 2004
    b>2B4 is a SLAM-related receptor expressed on natural killer (NK) cells and cytotoxic T cells. It can regulate killing and gamma interferon secretion by NK cells, as well as T-cell-mediated cytotoxicity...
  12. ncbi SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells
    Loïc Dupré
    San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, 20132 Milan, Italy
    Blood 105:4383-9. 2005
    ..This defect is associated with the defective polarization of 2B4, perforin, and lipid rafts at the contact area of CTLs with EBV-positive targets...
  13. ncbi Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244)
    Philipp Eissmann
    Institute for Immunology, University Heidelberg, Germany
    Blood 105:4722-9. 2005
    Triggering of 2B4 (CD244) can induce natural killer (NK)-cell activation, costimulation, or even inhibition of NK-cell activity. Here, we investigate the molecular basis for the different signals generated by 2B4...
  14. ncbi Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase
    Nicholas G Clarkson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 282:25385-94. 2007
    Engagement of the receptor CD244 (2B4) by its ligand CD48 has inhibitory and activating potential, and this differs depending on experimental systems in mouse and human...
  15. pmc Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1
    Nicholas G Clarkson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 284:24725-34. 2009
    Regulation by the NK and T cell surface receptor CD244 in mice and humans depends both on engagement at the cell surface by CD48 and intracellular interactions with SAP and EAT-2...
  16. doi The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function
    Bijan Raziorrouh
    Medical Department II and Institute for Immunology, Ludwig Maximilians University Munich, Munich, Germany
    Hepatology 52:1934-47. 2010
    ..present study, we investigated the role of the signaling lymphocyte activation molecule (SLAM)-related receptor CD244 and of programmed death 1 (PD-1) in HBV infection in 15 acutely and 66 chronically infected patients as well as 9 ..
  17. pmc 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis
    ANYA T BIDA
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, United States
    Mol Immunol 48:1149-59. 2011
    b>2B4 is a member of the SLAM receptor family capable of activating NK cell cytotoxicity in the context of EBV infection...
  18. pmc Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells
    Verena Schlaphoff
    Department for Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS Pathog 7:e1002045. 2011
    ..The NK cell receptor 2B4 (CD244) is a transmembrane protein belonging to the Ig superfamily which can also be expressed by CD8+ T cells...
  19. ncbi Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4
    K S Boles
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
    Tissue Antigens 54:27-34. 1999
    ..However, we have previously described an activating receptor, 2B4, expressed on all murine NK cells and a subset of T cells that mediate non-major histocompatibility complex (MHC) ..
  20. ncbi Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48
    M Z Kubin
    Department of Immunobiology, Immunex Corporation, Seattle, USA
    Eur J Immunol 29:3466-77. 1999
    ..and a proportion of CD8(+) T cells, we cloned a novel molecule we refer to as NK cell activation-inducing ligand (NAIL)...
  21. ncbi Molecular basis of the dual functions of 2B4 (CD244)
    Lukasz K Chlewicki
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 180:8159-67. 2008
    b>2B4 belongs to the CD2 family of molecules and is expressed on all NK, gammadelta, and memory CD8(+) (alphabeta) T cells...
  22. ncbi Identification of the 2B4 molecule as a counter-receptor for CD48
    Y Latchman
    Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    J Immunol 161:5809-12. 1998
    The CD48 molecule belongs to a subfamily of the Ig superfamily that also includes the CD2, CD58, 2B4, Signaling lymphocyte activation molecule (SLAM), and Ly-9 molecules...
  23. ncbi Pachyonychia congenita: therapeutic and immunologic aspects
    A E Rohold
    Department of Dermatology, Odense University Hospital, Denmark
    Pediatr Dermatol 7:307-9. 1990
    A 4-year-old girl with pachyonychia congenita was followed from birth. During childhood, slow progression of the nail hypertrophy was seen because she was not willing to have the nails ground or cut...
  24. ncbi Herlitz junctional epidermolysis bullosa presenting at birth with anonychia: a case report and review of H-JEB
    K Parsapour
    Departments of Pediatrics and Dermatology, Henry Ford Hospital, Detroit, Michigan, USA
    Pediatr Dermatol 18:217-22. 2001
    A 15-day-old Yemeni boy presented with anonychia and granulomatous nail beds and white patches in the mouth. Biopsy specimens from the nail beds were nondiagnostic...
  25. ncbi Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate
    M J Finnen
    Prostrakan Pharmaceuticals, Buckholm Mill Brae, Galashiels TS1 2HB, UK
    Br J Dermatol 157:494-500. 2007
    Topical treatment of nail diseases is hampered by the nail plate barrier, consisting of dense cross-linked keratin fibres held together by cysteine-rich proteins and disulphide bonds, which prevents penetration of antifungal agents to the ..
  26. doi Yellow nail syndrome: treatment with octreotide
    Gunnar Hillerdal
    Department of Lung Medicine and Allergy Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Clin Respir J 1:120-1. 2007
    The yellow nail syndrome (YNS) is the triad of 'yellow' nails, peripheral oedema and pleural effusions. For diagnosis, which is clinical, at least two of these findings are necessary...
  27. ncbi Cytochrome b5 increases the rate of product formation by cytochrome P450 2B4 and competes with cytochrome P450 reductase for a binding site on cytochrome P450 2B4
    Haoming Zhang
    Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan 48105, USA
    J Biol Chem 282:29766-76. 2007
    The kinetics of product formation by cytochrome P450 2B4 were compared in the presence of cytochrome b(5) (cyt b(5)) and NADPH-cyt P450 reductase (CPR) under conditions in which cytochrome P450 (cyt P450) underwent a single catalytic ..
  28. ncbi Congenital atrichia with nail dystrophy, abnormal facies, and retarded psychomotor development in two siblings: a new autosomal recessive syndrome?
    B R Vogt
    Department of Dermatology, University of Munster, West Germany
    Pediatr Dermatol 5:236-42. 1988
    ..We therefore conclude that we may be dealing with a new genetic entity. The occurrence of the disorder in two siblings with unaffected parents suggests an autosomal recessive mode of inheritance...
  29. doi Complications of titanium and stainless steel elastic nail fixation of pediatric femoral fractures
    Eric J Wall
    Division of Pediatric Orthopaedic Surgery, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Bone Joint Surg Am 90:1305-13. 2008
    ..The purpose of the present study was to compare the complications associated with the use of similarly designed titanium and stainless steel elastic nails for the fixation of pediatric femoral fractures...
  30. doi [Intramedullary nailing of the tibia with the expert tibia nail]
    Matthias Hansen
    Klinik für Unfall, Hand und Wiederherstellungschirurgie, Klinikum Worms, Worms, Germany
    Oper Orthop Traumatol 21:620-35. 2009
    ..Restoration of axis, length, and rotation of the lower leg. Sufficient primary stability of the osteosynthesis for functional aftercare. Early functional aftercare to maintain joint mobility. Good bony healing in closed and open fractures...
  31. ncbi [Three cases of removal of intrabronchial metal nails]
    Jun Nohara
    Department of Respiratory Medicine, Nagahama City Hospital
    Nihon Kokyuki Gakkai Zasshi 47:1098-102. 2009
    ..They were all carpenters, and often held nails between their lips. Case 1: a 72-year-old man had aspirated a nail three months earlier, but did not seek medical assistance at the time...
  32. ncbi A survey of childhood psoriasis in Kuwait
    A S Al-Fouzan
    Department of Dermatology, Al-Sabah Hospital, Kuwait
    Pediatr Dermatol 11:116-9. 1994
    ..A majority of the children had a milder form of disease. Nail involvement was seen in 36%, with pitting the most common feature (87%). Seven percent had mucosal involvement...
  33. ncbi Cutaneous manifestations of childhood systemic lupus erythematosus
    S Wananukul
    Department of Pediatrics, Chulalongkorn University, Bangkok, Thailand
    Pediatr Dermatol 15:342-6. 1998
    ..All 11 discoid LE patients were girls. Periungual erythema, Raynaud's phenomenon, periungual gangrene, nail involvement, and subacute LE were rare...
  34. ncbi Steroid sulfatase activity in nails: screening for X-linked ichthyosis
    T Matsumoto
    Department of Pediatrics, Hiroshima University School of Medicine, Japan
    Pediatr Dermatol 7:266-9. 1990
    ..We established a method of assaying nail steroid sulfatase activity for diagnostic use...
  35. ncbi Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity
    Robert H Rice
    Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616 8588, USA
    Arch Dermatol Res 297:127-33. 2005
    ..cornified envelopes (CEs) have been reported by light or electron microscopic examination in epidermal scale, nail and/or hair...
  36. ncbi Comparison of nail bed repair versus nail trephination for subungual hematomas in children
    S E Roser
    Department of Orthopaedic Surgery, University of Arkansas for Medical Science, Little Rock 72205, USA
    J Hand Surg Am 24:1166-70. 1999
    ..Criteria for inclusion into the study were an intact nail and nail margin with subungual hematoma and no previous nail abnormality...
  37. ncbi Lichen planus limited to the nails in childhood: case report and literature review
    A M Peluso
    Department of Dermatology, University of Bologna, Italy
    Pediatr Dermatol 10:36-9. 1993
    Although nail abnormalities have been reported to occur in 1% to 10% of patients with lichen planus, in children with lichen planus they are rarely mentioned in the literature...
  38. doi Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model
    Mahmoud A Ghannoum
    Center for Medical Mycology, Case Western Reserve University, Cleveland, OH 44106 5028, USA
    Mycoses 52:35-43. 2009
    Currently available topical antifungals are often not satisfactory for the treatment of nail infections, because of the inability to penetrate the nail plate...
  39. ncbi [DNA extraction and identification of Trichophyton rubrum by real-time polymerase chain reaction from direct nail scraping specimens of patients with onycomycosis]
    Elife Berk
    Kayseri Research and Training Hospital, Microbiology Clinics, Kayseri, Turkey
    Mikrobiyol Bul 45:150-8. 2011
    ..rubrum by comparing to DME and culture methods, from nail samples of patients with the complaints of onychomycosis...
  40. ncbi Epidermolysis bullosa simplex herpetiformis of Dowling-Meara with mottled pigmentation: the relationship between EBS herpetiformis and EBS with mottled pigmentation
    Y K Tay
    Department of Dermatology, University of Colorado Health Sciences Center, Denver 80262, USA
    Pediatr Dermatol 13:306-9. 1996
    ..features include generalized herpetiform blistering of the skin, healing without scars, intraoral blistering, nail dystrophy, palmoplantar keratoderma, and improvement with age...
  41. ncbi The sequelae of reflex sympathetic dystrophy
    A Zyluk
    Department of General and Hand Surgery, Pomeranian Medical University, Szczecin, Poland
    J Hand Surg Br 26:151-4. 2001
    ..of pain related to the weather, and many complained of cold intolerance (44%), slight pain after use (34%), nail and hair growth changes (34%), sensory disturbances (34%) and stiffness of fingers in the morning (28%)...
  42. ncbi Herlitz junctional epidermolysis bullosa: a case report and review of current diagnostic methods
    T Basarab
    Department of Dermatology, Ealing Hospital NHS Trust, Middlesex, England
    Pediatr Dermatol 14:307-11. 1997
    ..bullosa (JEB) presenting at birth with erosions on the scalp, thigh and periumbilical area in addition to nail abnormalities...
  43. ncbi Single-blind, randomized, prospective study on terbinafine and itraconazole for treatment of dermatophyte toenail onychomycosis in the elderly
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
    J Am Acad Dermatol 44:479-84. 2001
    ..Although comparative studies have been performed evaluating the efficacy of these 2 agents in adults, no such studies have been reported specifically in the elderly subset...
  44. pmc Homotypic cell to cell cross-talk among human natural killer cells reveals differential and overlapping roles of 2B4 and CD2
    Eun Ok Kim
    Department of Biochemistry, Division of Brain Korea 21 Program for Biomedical Science, Global Research Lab, Korea University College of Medicine, Seoul, Korea
    J Biol Chem 285:41755-64. 2010
    Human natural killer (NK) cells express an abundant level of 2B4 and CD2 on their surface...
  45. ncbi A computer assisted orthopaedic surgical system for distal locking of intramedullary nails
    W J Viant
    Department of Computer Science, University of Hull
    Proc Inst Mech Eng H 211:293-300. 1997
    ..software to analyse the operation site and calculate the trajectory required for a screw to lock an intramedullary nail. This involves the capture of two X-ray images from which are extracted the projections of the nail's edge ..
  46. ncbi The handheld dermatoscope as a nail-fold capillaroscopic instrument
    Reuven Bergman
    Departments of Dermatology and Rheumatology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Arch Dermatol 139:1027-30. 2003
    The presence of nail-fold capillary abnormalities may be useful in diagnosing several connective tissue disorders, including scleroderma, dermatomyositis, and mixed connective tissue disease, and in differentiating primary Raynaud ..
  47. pmc The interaction of microsomal cytochrome P450 2B4 with its redox partners, cytochrome P450 reductase and cytochrome b(5)
    Sang Choul Im
    University of Michigan Medical School and VA Medical Center, Ann Arbor, MI 48105, USA
    Arch Biochem Biophys 507:144-53. 2011
    Cytochrome P450 2B4 is a microsomal protein with a multi-step reaction cycle similar to that observed in the majority of other cytochromes P450...
  48. ncbi Nail matrix arrest following hand-foot-mouth disease: a report of five children
    G C Clementz
    Department of Pediatrics, Northwestern University Medical School, Children's Memorial Hospital, Chicago, Illinois, USA
    Pediatr Dermatol 17:7-11. 2000
    ..b>Nail matrix arrest has been associated with a variety of drug exposures and systemic illnesses, including infections, ..
  49. ncbi Nephropathy of nail-patella syndrome
    T Taguchi
    Department of Pathology and Pediatrics, School of Medicine, Fukuoka University, Japan
    Ultrastruct Pathol 12:175-83. 1988
    Ultrastructural renal lesions of a sporadic case of nail-patella syndrome are described...
  50. ncbi New concepts in the treatment of ankle joint fractures. The IP-XS (XSL) and IP-XXS (XXSL) nail in the treatment of ankle joint fractures
    J Gehr
    Klinikum Aschaffenburg, Abtl Unfall Hand und Wiederherstellungschirurgie, Am Hasenkopf 1, 63739, Aschaffenburg, Germany
    Arch Orthop Trauma Surg 124:96-103. 2004
    ..The choice of surgical access route, in particular in the case of critical arterial circulation, and the possible irritation of the soft tissue by the osteosynthesis material prompted us to seek alternative osteosynthesis techniques...
  51. ncbi Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed
    C Perrin
    Hôpital L Pasteur, Laboratoire d Anatomie Pathologique, 30 Av voie Romaine, B P 69, 06002 Nice, Cedex 1, France
    Br J Dermatol 151:362-71. 2004
    Recently, the expression profiles of the members of the complex hair keratin family have been determined in the human anagen hair follicle. In contrast, the details of hair keratin expression in the human nail unit are poorly known.
  52. ncbi Diagnosis of Trichophyton rubrum from onychomycotic nail samples using polymerase chain reaction and calcofluor white microscopy
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Center, and the University of Toronto, Toronto, Ontario, Canada
    J Am Podiatr Med Assoc 98:224-8. 2008
    ..These methods include microscopic observation of potassium hydroxide-digested nail clippings and culture methods using agar-based media supplemented with cycloheximide, chloramphenicol, and ..
  53. ncbi A clinical study of childhood alopecia areata in Chandigarh, India
    V K Sharma
    Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pediatr Dermatol 13:372-7. 1996
    ..5% for circumscribed and severe alopecia, respectively; p > 0.05). Nail changes were found in 60 (30%) children and were more frequent in severe alopecia (53%) than in circumscribed ..
  54. ncbi Clinical features and long-term follow-up of 20 cases of parakeratosis pustulosa
    A Tosti
    Department of Dermatology, University of Bologna, Italy
    Pediatr Dermatol 15:259-63. 1998
    ..Of these, three children had skin psoriasis at the time of our observation, two developed nail psoriasis, and three developed psoriatic pitting during follow-up...
  55. ncbi Expression of follicular sheath keratins in the normal nail with special reference to the morphological analysis of the distal nail unit
    Christophe Perrin
    Hôpital L Pasteur, Laboratoire Central d Anatomie Pathologique, University of Nice, France
    Am J Dermatopathol 29:543-50. 2007
    The origin and the histology of the distal nail unit remain controversial. For some authors the nail bed is completely derived from the matrix epithelium and is not a self-regenerating, independent structure...
  56. ncbi A randomized trial of amorolfine 5% solution nail lacquer in association with itraconazole pulse therapy compared with itraconazole alone in the treatment of Candida fingernail onychomycosis
    D Rigopoulos
    National and Kapodistrian University of Athens, Department of Dermatology and Venereology, A Sygros Hospital, 5 Dragoumi Str, Athens 16121, Greece
    Br J Dermatol 149:151-6. 2003
    ..Therefore, it is worthwhile to consider the combination of systemic and topical antifungals to improve the cure rates further and to reduce the duration of systemic treatment...
  57. ncbi Free and island vascularized joint transfer for proximal interphalangeal reconstruction: a series of 27 cases
    G Foucher
    SOS Main Strasbourg, France
    J Hand Surg Am 19:8-16. 1994
    ..Four complications occurred in the homodigital island joint series: one sepsis, one nail dystrophy, one failed distal arthrodesis, and one bone abutment in flexion...
  58. ncbi Psoriasiform acral dermatitis: a peculiar clinical presentation of psoriasis in children
    A Patrizi
    Department of Clinical and Experimental Medicine, Division of Dermatology, University of Bologna, Italy
    Pediatr Dermatol 16:439-43. 1999
    ..It is characterized by cutaneous involvement of the digits without nail dystrophy...
  59. ncbi Congenital hypertrophy of the lateral nail folds of the hallux: clinical features and follow-up of seven cases
    B M Piraccini
    Department of Dermatology, University of Bologna, Italy
    Pediatr Dermatol 17:348-51. 2000
    Congenital hypertrophy of the nail folds of the hallux describes an abnormality of the periungual soft tissues of the big toe characterized by hypertrophy of the nail fold which partially covers the nail plate and is frequently associated ..
  60. ncbi The effect of concurrent fibular fracture on the fixation of distal tibia fractures: a laboratory comparison of intramedullary nails with locked plates
    Eric J Strauss
    Department of Orthopedic Surgery, NYU Hospital for Joint Diseases, New York, NY 10016, USA
    J Orthop Trauma 21:172-7. 2007
    ..To compare the fixation stability of intramedullary nails to that of locked plates for the treatment of distal metaphyseal tibia and fibula fractures...
  61. ncbi [Treatment of mallet finger with dorsal nail glued splint: retrospective analysis of 270 cases]
    S Facca
    SOS Main Strasbourg Hôpitaux Universitaires, Centre de Chirurgie Orthopédique et de la Main, 10, avenue Achille Baumann, 67403 Illkirch Cedex
    Rev Chir Orthop Reparatrice Appar Mot 93:682-9. 2007
    ..Despite the large number of orthopedic methods proposed, none has proven superiority. We report here our experience with a dorsal adhesive splint which preserves digital pulp function and improves observance...
  62. pmc Study to prospectively evaluate reamed intramedually nails in patients with tibial fractures (S.P.R.I.N.T.): study rationale and design
    Mohit Bhandari
    SPRINT Methods Center, Department of Clinical Epidemiology and Biostatistics, 1200 Main Street West, Room 2C9 Hamilton, Ontario, Canada
    BMC Musculoskelet Disord 9:91. 2008
    ..of operative treatment of tibial fractures - the most common of long bone fractures - with an intramedullary rod or nail. Rates of re-operation remain high - between 23% and 60% in prior trials - and the two alternative nailing ..
  63. ncbi Digital replantation at the level of the distal interphalangeal joint and the distal phalanx
    R D Goldner
    Division of Orthopaedic Surgery, Duke University Medical Center, Durham, N C 27710
    J Hand Surg Am 14:214-20. 1989
    ..soft tissue coverage, adequate sensibility without painful neuroma, good metacarpophalangeal and proximal interphalangeal joint motion; it preserves the nail, maintains digit length, is cosmetically pleasing, and the patient is satisfied.
  64. ncbi Immediate weight-bearing after treatment of a comminuted fracture of the femoral shaft with a statically locked intramedullary nail
    R J Brumback
    Section of Orthopaedics, Program in Trauma, The R Adams Cowley Shock Trauma Center, The University of Maryland Medical System, Baltimore 21201 1595, USA
    J Bone Joint Surg Am 81:1538-44. 1999
    The purpose of this two-part investigation was to test the feasibility, safety, and efficacy of immediate weight-bearing after treatment of fractures of the shaft of the femur with a statically locked intramedullary nail.
  65. ncbi Cytochrome b5 inhibits electron transfer from NADPH-cytochrome P450 reductase to ferric cytochrome P450 2B4
    Haoming Zhang
    Department of Anesthesiology, University of Michigan Medical School and Veterans Affairs Medical Center, Ann Arbor, Michigan 48105, USA
    J Biol Chem 283:5217-25. 2008
    Experiments demonstrating that cytochrome (cyt) b5 inhibits the activity of cytochrome P450 2B4 (cyt P450 2B4) at higher concentrations suggested that cyt b5 was occupying the cyt P450 reductase-binding site on cyt P450 2B4 and ..
  66. pmc Distraction osteogenesis technique using an intramedullary nail and a monolateral external fixator in the reconstruction of massive postosteomyelitis skeletal defects of the femur
    Zhihong Li
    Department of Orthopaedics, 2nd Xiangya Hospital, Center South University, Changsha, Hunan, China
    Can J Surg 52:103-11. 2009
    ..of our study was to summarize our experience performing a distraction osteogenesis technique using an intramedullary nail and a monolateral external fixator in the reconstruction of massive postosteomyelitis skeletal defects of the femur.
  67. ncbi Results of treatment of subtrochanteric femoral fractures with the AO/ASIF Long Trochanteric Fixation Nail (LTFN)
    E Muñoz-Mahamud
    Department of Orthopaedic and Trauma Surgery, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain
    Acta Chir Orthop Traumatol Cech 76:451-5. 2009
    This retrospective study reports on the clinical results of a group of 23 patients with subtrochanteric femoral fractures using the Long Trochanteric Fixation Nail (LTFN).
  68. ncbi Epidermolysis bullosa dystrophica inversa in a child
    L Bruckner-Tuderman
    Department of Dermatology, University Hospital, , Switzerland
    Pediatr Dermatol 7:116-21. 1990
    ..Notably, the hands and feet were completely spared, with only mild nail dystrophy. Ultrastructural analysis revealed dermolytic blistering and absent or rudimentary anchoring fibrils...
  69. ncbi Diffuse whitening of the oral mucosa in a child
    A Hernandez-Martin
    Department of Dermatology, Hospital Universitario of Salamanca, Spain
    Pediatr Dermatol 14:316-20. 1997
    ..No other mucosae were affected and there were no skin or nail abnormalities...
  70. ncbi [The prosthesis nail -- a new stable fixation device for periprosthetic fractures and critical fractures of the proximal femur]
    A Probst
    Abteilung für Unfall und Handchirurgie, Hegau Klinikum GmbH, Singen
    Unfallchirurg 106:722-31. 2003
    ..The prosthesis nail is a hybrid of a hip prosthesis and an intramedullary nail allowing immediate full weight bearing and early ..
  71. ncbi Internal fixation of diaphyseal fractures of the forearm by interlocking intramedullary nail: short-term results in eighteen patients
    Hong Gao
    Department of Orthopaedics, The Sixth Affiliated People s Hospital of Jiaotong University, Shanghai, China of PR
    J Orthop Trauma 19:384-91. 2005
    This study was designed to evaluate the efficacy of the treatment of diaphyseal fractures of the forearm using the ForeSight forearm interlocking intramedullary nail.
  72. ncbi Itraconazole in the treatment of two young brothers with chronic mucocutaneous candidiasis
    A Tosti
    Department of Dermatology, University of Bologna, Italy
    Pediatr Dermatol 14:146-8. 1997
    ..This therapy produced a rapid cure of both candidal nail and mouth infections...
  73. ncbi Cosegregation of open-angle glaucoma and the nail-patella syndrome
    P R Lichter
    Department of Ophthalmology, University of Michigan, Ann Arbor 48105, USA
    Am J Ophthalmol 124:506-15. 1997
    To evaluate two families ascertained only for the presence of glaucoma in which both nail-patella syndrome and glaucoma occur in several generations and to determine whether the two diseases are genetically related.
  74. doi Improvement of psoriatic onychodystrophy by a water-soluble nail lacquer
    F Cantoresi
    Department of Dermatology, La Sapienza University, Rome, Italy
    J Eur Acad Dermatol Venereol 23:832-4. 2009
    There is a strong need for effective products, simple to use and safe for a chronic use in the management of nail psoriasis...
  75. pmc Fibular strut grafting for fibrous dysplasia of the femoral neck
    D D Bryant
    Division of Orthopaedic Surgery, Howard University Hospital, Washington, DC
    J Natl Med Assoc 84:893-7. 1992
    ..Surgical options include curettage and cancellous bone grafting, osteotomy and nail-plate fixation, intramedullary rodding, and cortical bone grafting...
  76. ncbi Epidermolysis bullosa simplex associated with muscular dystrophy: a new case
    A Patrizi
    Department of Dermatology, University of Bologna, Italy
    Pediatr Dermatol 11:342-5. 1994
    ..simplex characterized by an autosomal recessive pattern of inheritance, severe cutaneous involvement, oral and nail lesions, associated with muscular dystrophy, and a poor prognosis, due to extracutaneous disease...
  77. ncbi Prevalence and nature of nail alterations in pediatric patients
    A Iglesias
    Department of Pediatric Dermatology, National Institute of Pediatrics, Mexico City, Mexico
    Pediatr Dermatol 18:107-9. 2001
    ..The first 20 patients with nail alterations seen each year during a 5-year period from 1992 through 1996 were included, totaling 100 patients...
  78. ncbi [Nail susceptibility to fungal infection in patients with type 1 and 2 diabetes under long term poor glycaemia control]
    Anna B Macura
    Zakład Mykologii Katedry Mikrobiologii, Collegium Medicum, Uniwersytetu Jagiellonskiego w Krakowie
    Przegl Lek 64:406-9. 2007
    ..Its prevalence increases also in diabetics. The objective of the study was: 1) evaluation of finger and toe nail susceptibility to Candida albicans and Trichophyton mentagrophytes infection in patients with type 1 and type 2 ..
  79. ncbi Nail primer cosmetics: correlations between product pH and adequacy of labeling
    A D Woolf
    Children s Hospital, Boston, Massachusetts 02115, USA
    J Toxicol Clin Toxicol 37:827-32. 1999
    We have previously reported on injuries suffered by young children exposed to methacrylic acid-containing nail primers and the need for public education efforts concerning this potential household hazard...
  80. ncbi Molecular characterization of the rat NK cell receptor 2B4
    P R Kumaresan
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    Mol Immunol 37:735-44. 2000
    2B4 (CD244) is a cell surface glycoprotein of the immunoglobulin superfamily involved in the regulation of natural killer and T lymphocyte function. It is the high affinity counter-receptor for CD48...
  81. ncbi [Duration of surgery in osteosynthesis of fractures of the trochanter]
    J Bartonicek
    Ortopedicko traumatologická klinika 3 LF UK a FNKV, Praha Vinohrady
    Acta Chir Orthop Traumatol Cech 68:294-9. 2001
    ..To analyze duration of surgery in individual types of internal fixation of fractures of the trochanteric massif and identify factors which have an impact on it...
  82. ncbi Down syndrome, alopecia universalis, and trachyonychia
    S A Norton
    Department of Medicine, Fitzsimons Army Medical Center, Aurora, Colorado
    Pediatr Dermatol 10:187-8. 1993
    ..We were unable to detect fungi, and believe that his nail changes are most consistent with alopecia-associated trachyonychia (formerly 20-nail dystrophy), a condition not ..
  83. ncbi Anatomic variations in sensory innervation of the hand and digits
    H Bas
    Department of Surgery, University of Louisville School of Medicine, KY, USA
    J Hand Surg Am 24:1171-84. 1999
    ..The dorsal sensory nerves (the terminal branch of radial or ulnar sensory nerves) extending to the nail bed area were found in 46% of the digits, thus confirming that sensory supply to the dorsum of the distal phalanx ..
  84. ncbi Examination of the anatomic relationship of the proximal germinal nail matrix to the extensor tendon insertion
    C Shum
    Department of Orthopaedic Surgery, New York Orthopaedic Hospital, Columbia University, New York, NY, USA
    J Hand Surg Am 25:1114-7. 2000
    ..was to delineate the relationship of the terminal extensor tendon insertion to the proximal limit of the germinal nail matrix...
  85. ncbi [Treatment of intracapsular femoral neck fractures with the use of a proximal femoral nail]
    P Visna
    Traumatologické oddelení, Chirurgická klinika 2 LF UK a FN Motol, Praha
    Acta Chir Orthop Traumatol Cech 74:37-46. 2007
    ..The aim of this study was to evaluate the outcomes of surgical therapy using a different type of implant (proximal femoral nail) for intracapsular femoral neck fractures.
  86. ncbi Open fractures of the tibia treated by immediate intramedullary tibial nail insertion without reaming: a prospective study
    S Kakar
    Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA 02118, USA
    J Orthop Trauma 21:153-7. 2007
    Does immediate tibial nail insertion without reaming as part of protocol-driven management provide a safe and effective treatment for open tibia fractures?
  87. doi Provider factors associated with intramedullary nail use for intertrochanteric hip fractures
    Mary L Forte
    Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA
    J Bone Joint Surg Am 92:1105-14. 2010
    ..Non-patient factors that are associated with intramedullary nail use among Medicare patients have not been examined...
  88. ncbi Proximal femoral fractures: a biomechanical study to compare intramedullary and extramedullary fixation
    M J Curtis
    Johns Hopkins University, Baltimore, Maryland
    Injury 25:99-104. 1994
    ..and unstable intertrochanteric fractures were studied in paired femora after internal fixation with the Gamma nail and Richards 135 degrees classic hip-screw implants; in subtrochanteric fractures, the 95 degrees Richards condylar ..
  89. ncbi Enhanced econazole penetration into human nail by 2-n-nonyl-1,3-dioxolane
    Xiaoying Hui
    Department of Dermatology, University of California San Francisco, Surge pound 110, Box 0989, 90 Medical Center Way, San Francisco, California 94143 0989, USA
    J Pharm Sci 92:142-8. 2003
    ..of 2-n-nonyl-1,3-dioxolane on the penetration of econazole, an antifungal drug, into the deeper layers of the human nail where fungal infection resides. Aliquots (10 microL) of Econail lacquer formulation containing 0...
  90. ncbi The Targon PH nail as an internal fixator for unstable fractures of the proximal humerus
    Jochen Mathews
    Chirurgie, Krankenhaus Soltau, Heidekreis Klinikum, Soltau
    Oper Orthop Traumatol 19:255-75. 2007
    ..Exercise-stable internal fixation of unstable fractures of the proximal humerus...
  91. doi Bilayered nail lacquer of terbinafine hydrochloride for treatment of onychomycosis
    H N Shivakumar
    Department of Pharmaceutics, The University of Mississippi, University, Mississippi 38677, USA
    J Pharm Sci 99:4267-76. 2010
    The present study aimed to develop bilayered nail lacquer of terbinafine hydrochloride (TH) for treatment of onychomycosis...
  92. ncbi Prevalence of nail abnormalities in children with alopecia areata
    A Tosti
    Department of Dermatology, University of Bologna, Italy
    Pediatr Dermatol 11:112-5. 1994
    We assessed the prevalence of nail abnormalities in 272 children with alopecia areata who were seen in our department during an eight-year period...
  93. ncbi [Yellow nail syndrome]
    M Hausmann
    Pneumologische Abteilung, Klinik Barmelweid
    Pneumologie 48:30-3. 1994
    The yellow nail syndrome, first described in 1964 by Samman and White, consists of yellowish, dystrophic nails, lymphedema and pleural effusion...
  94. ncbi Retrograde femoral interlocking nail in complex fractures
    Khare Anup
    S R Hospital, Agra, India
    J Orthop Surg (Hong Kong) 10:17-21. 2002
    Retrograde interlocking nail was used as the method of fixation in 35 different cases of combination of complex femoral fractures...
  95. ncbi [Osteosynthesis of proximal femoral fractures using short proximal femoral nails]
    T Pavelka
    Klinika ortopedie a traumatologie pohybového ústrojí FN Plzeň
    Acta Chir Orthop Traumatol Cech 70:31-8. 2003
    A group of 147 patients with proximal femoral fractures treated with the use of the proximal femoral nail, manufactured by the Synthes company, in the period between October 1997 and June 2001 were retrospectively evaluated.
  96. ncbi Bioadhesive patch-based delivery of 5-aminolevulinic acid to the nail for photodynamic therapy of onychomycosis
    Ryan F Donnelly
    School of Pharmacy, Queens University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    J Control Release 103:381-92. 2005
    The in vitro penetration of 5-aminolevulinic acid (ALA) across human nail and into neonate porcine hoof when released from a novel bioadhesive patch containing 50 mg cm(-2) ALA is described...
  97. ncbi Cephalomedullary nails in the treatment of high-energy proximal femur fractures in young patients: a prospective, randomized comparison of trochanteric versus piriformis fossa entry portal
    Adam J Starr
    Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390 8883, USA
    J Orthop Trauma 20:240-6. 2006
    The purpose of this study is to compare a cephalomedullary nail that uses a piriformis fossa starting point to one that uses a trochanteric starting point, in the treatment of high-energy proximal femur fractures in young patients...
  98. pmc Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel
    Sean C Gay
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, USA
    Biochemistry 49:8709-20. 2010
    Prior X-ray crystal structures of rabbit cytochrome P450 2B4 (2B4) in complexes with various imidazoles have demonstrated markedly different enzyme conformations depending on the size of the inhibitor occupying the active site...
  99. ncbi A modified approach to the histologic diagnosis of onychomycosis
    Anwell Chang
    Section of Dermatopathology, New York University School of Medicine, New York, New York 10016, USA
    J Am Acad Dermatol 57:849-53. 2007
    Histologic examination of nail clippings with periodic acid-Schiff staining is the most sensitive diagnostic test for onychomycosis; however, difficulties in processing nail plates limit its use...
  100. ncbi Congenital onychodysplasia of the index fingers
    T Miura
    Department of Orthopaedic Surgery, School of Medicine, Nagoya University, Japan
    J Hand Surg Am 15:793-7. 1990
    ..Some cases of congenital onychodysplasia of the index fingers were inherited. These findings suggest that impediments to the membranous ossification center can lead to a dysplastic crescent-shaped cap with nail anomalies.
  101. ncbi Nail regeneration in digits replanted after amputation through the distal phalanx
    G Nishi
    Department of Orthopaedic Surgery, Aichiken Koseiren Kainan Hospital, Aichi, Japan
    J Hand Surg Am 21:229-33. 1996
    b>Nail regeneration was studied in 48 digits replanted after amputation through the distal phalanx. Twenty-seven were amputated through Tamai's zone I, at the nailbed level, and 21 digits were amputated through zone II, proximal to the nail...

Research Grants88

  1. Iontophoresis to Improve Nail Disease Treatment
    KEVIN S LI; Fiscal Year: 2012
    ..has fewer adverse effects than systemic administration, but has not been very successful due to the resistive nail barrier. Transungual drug delivery for nail diseases has remained a challenge to pharmaceutical scientists...
  2. SPRINT- Randomized Trial of Tibial Fracture Fixation
    Marc Swiontkowski; Fiscal Year: 2006
    ..However, the decision to, ream or enlargen the intirarnedullary canal prior to nail insertion remains controversial...
  3. Electropulsation mediated drug therapy for Onychomycosis
    SATHYANARAYANA MURTHY; Fiscal Year: 2009
    ..Onychomycoses are fungal infections of both the fingernails and the toenails accounting for up to 50% of all the nail disorders. They are currently treated by oral and topical administration of the antifungal drugs...
  4. A molecular toolbox for hypothesis testing in the dermatophytes
    Theodore C White; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Dermatophytes are pathogenic fungi responsible for a variety of skin and nail infections, including athlete's foot and tinea capitis, a common fungal infection of the head in patients in ..
  5. BLOOD AND DATA BANK FOR CANCER RISK FACTOR STUDIES
    George Comstock; Fiscal Year: 1992
    ..participants will be asked to complete dietary questionnaires at their leisure and to return them along with a toe nail clipping for trace metal analyses...
  6. INTERLOCKING NAIL PLACEMENT WITHOUT FLUOROSCOPY
    GREGORY MERCURI; Fiscal Year: 2000
    ..targeting device and guide system is proposed for securing distal interlocking screws to a cannulated, interlocking nail during stabilization of long bone fractures...
  7. TARGETING DEVICE FOR INTRAMEDULLARY NAIL LOCKING SCREWS
    RUBEN ZAMORANO; Fiscal Year: 1999
    DESCRIPTION (Adapted from the applicant's abstract): Spry Medical's proposed Fixator for Interlocking Nail (FIN) system seeks to reduce or eliminate the placement difficulties and operating room personnel radiation exposure related to ..
  8. Ultraviolet-C Therapy for Onychomycosis
    MICHAEL HAMBLIN; Fiscal Year: 2006
    ..Onychomycosis is a fungal nail infection that affects approximately 30 million Americans...
  9. MOLECULAR GENETICS OF NAIL PATELLA SYNDROME
    Iain McIntosh; Fiscal Year: 2004
    b>Nail Patella Syndrome (NPS) is a diverse phenotype inherited in an autosomal dominant manner. The syndrome is characterized by dysplasia of the nails, patellae and elbows, as well as open angle glaucoma and potentially lethal nephropathy...
  10. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..family style meals, and 7) an effective lay health intervention to reduce chemical exposure in the workplace among nail salon workers...
  11. JAMES TILFORD ELDER; Fiscal Year: 2016
    ..peripheral PsA and nail involvement, and (iii) systemic co-morbidities including obesity and cardiovascular disease...
  12. NATIONAL CHILDREN'S STUDY - CACHE COUNTY STUDY CENTER
    Edward Clark; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  13. Monica Bessler; Fiscal Year: 2014
    ..form of BMF associated with a classic triad of mucocutaneous features including abnormal pigmentation, dystrophic nail changes, and leukoplakia of the oral mucosa...
  14. George J Schwartz; Fiscal Year: 2016
    ..CBL also provides the kits and instructions for collection and shipment of blood, plasma, sera, urine, hair, and nail samples to NIH repositories...
  15. NATIONAL CHILDREN'S STUDY SUPPORT
    Betty Wood; Fiscal Year: 2013
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  16. NATIONAL CHILDREN'S STUDY -CLINICAL BIOLOGICAL ANALYSIS
    VELAZQUEZ FRANCISCO; Fiscal Year: 2011
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  17. NATIONAL CHILDREN'S STUDY SUPPORT
    Betty Wood; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  18. NATIONAL CHILDREN'S STUDY SUPPORT
    Betty Wood; Fiscal Year: 2011
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  19. Kathleen M Egan; Fiscal Year: 2014
    ..b>Nail clippings to measure levels of trace elements and oral DNA samples to study genetic susceptibility are available ..
  20. NATIONAL CHILDREN'S STUDY COORDINATING CENTER
    Elaine D Eaker; Fiscal Year: 2009
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  21. NATIONAL CHILDREN'S STUDY
    William Hogan; Fiscal Year: 2013
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  22. NATIONAL CHILDREN'S STUDY
    DANA DABALEA; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  23. SUPPORT OF THE NATIONAL CHILDREN'S STUDY INFORMATION SYSTEM
    JAMES TER MAAT; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  24. NATIONAL CHILDREN'S STUDY
    Helen Koo; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  25. NATIONAL CHILDREN'S STUDY BIOMEDICAL (APPLIED/EXPLORATORY)
    Lee Smith; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  26. NATIONAL CHILDREN'S STUDY SUPPORT
    Russell Walker; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  27. NATIONAL CHILDREN'S STUDY
    Helen Koo; Fiscal Year: 2013
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  28. NATIONAL CHILDREN'S STUDY
    Kristina Lewis; Fiscal Year: 2013
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  29. NATIONAL CHILDREN'S STUDY BIOMEDICAL (APPLIED/EXPLORATORY)
    Lee Smith; Fiscal Year: 2011
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  30. Sujuan Gao; Fiscal Year: 2014
    ..finding that apolipoprotein E (APOE) 54 allele carriers had significantly lower selenium levels measured in nail samples even though the two genotype groups did not differ on dietary intake of selenium...
  31. NATIONAL CHILDREN'S STUDY - PROGRAM &PLANNING SUPPORT FOR THE NCS PROGRAM OFFICE
    RAJNI SAMAVEDAM; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  32. NATIONAL CHILDREN'S STUDY - PROGRAM &PLANNING SUPPORT FOR THE NCS PROGRAM OFFICE
    RAJNI SAMAVEDAM; Fiscal Year: 2013
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  33. NATIONAL CHILDREN'S STUDY - SCHUYLKILL COUNTY STUDY CENTER
    Jennifer Culhane; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  34. LOGISTICS FOR NATIONAL CHILDREN'S STUDY
    David J Tollerud; Fiscal Year: 2009
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  35. NATIONAL CHILDREN'S STUDY
    JANUARY HRICISAK; Fiscal Year: 2013
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  36. Eric B Larson; Fiscal Year: 2014
    ..susceptibility, specifically to Clostridium difficile diarrhea, shingles from varicella zoster virus, and fungal nail infection, responses to antihypertensive drugs, serotonin-specific reuptake inhibitors, and statins, including ..
  37. NATIONAL CHILDREN'S STUDY, VANGUARD CENTER
    PHIL LANDRIGAN; Fiscal Year: 2011
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  38. NATIONAL CHILDREN'S STUDY BIOLOGICAL AND ENVIRONMENTAL SAMPLE REPOSITORY
    HANNAH ELSON; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  39. NATIONAL CHILDRENS STUDY
    TORRISE WOODY; Fiscal Year: 2011
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  40. NATIONAL CHILDREN'S STUDY
    LOUIS FLICK; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  41. NATIONAL CHILDREN'S STUDY
    George Lister; Fiscal Year: 2011
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  42. NATIONAL CHILDREN'S STUDY
    Cheryl Wiggins; Fiscal Year: 2013
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  43. NATIONAL CHILDREN'S STUDY
    Edward Clark; Fiscal Year: 2013
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  44. NATIONAL CHILDREN'S STUDY - COORDINATING CENTER
    CLAIRE GREENING; Fiscal Year: 2013
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  45. NATIONAL CHILDREN'S STUDY
    Stephen Buka; Fiscal Year: 2011
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  46. NATIONAL CHILDREN'S STUDY
    Anthony Mawson; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  47. NATIONAL CHILDREN'S STUDY, VANGUARD CENTER
    Barbara Entwisle; Fiscal Year: 2012
    ..Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children;blood, urine, and hair from fathers;cord blood, umbilical cord and placental ..
  48. Cortical connections with the limbic territory of the basal ganglia
    Michelle Morrow; Fiscal Year: 2007
    ..of the external segment of the Globus Pallidus (GPe) evoke abnormal behaviors including excessive grooming, nail biting, and communicative gestures...
  49. HEMOSTATIC DEFECTS AND THYROID HORMONE THERAPY
    WINIFRED DODDS; Fiscal Year: 1990
    ..The levels of FVIII:C, VWF:Ag and VWF:RCoF will be correlated with alterations in cuticle (toe nail) bleeding times and FVIII multimeric profiles...
  50. Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania
    Joseph Himle; Fiscal Year: 2007
    ..could be used to help treat other body-focused repetitive behavior problems such as skin picking, finger and nail biting...
  51. ELIA Tactile Label Maker
    ANDREW CHEPAITIS; Fiscal Year: 2009
    ..distinguishing objects typically include varying the number or placement of rubber bands, dots made of glue, felt, nail polish, strands of yarn, safety pins, magnets, pieces of tape, or other common materials...
  52. Community Mapping of Environmental Hazards and Barriers in an Immigrant Populatio
    Peggy Reynolds; Fiscal Year: 2010
    ..project focused on the recently high profile concerns of health risks from chemical exposures in the burgeoning nail salon industry, an industry dominated in California by Vietnamese immigrant workers...
  53. TRACE ELEMENTS & CANCERS OF THE LARYNX/ESOPHAGUS & MOUTH
    David Thomas; Fiscal Year: 1991
    ..to what has already been collected will be obtained from interviews, dietary questionnaires, and analysis of nail specimens...
  54. MSX GENES IN WOUND HEALING AND REGENERATION
    Ken Muneoka; Fiscal Year: 2000
    ..g. epidermis, nail, nailbed, dermis, adipose, bone), and in response to amputation, a perfect replica of the tip of the digit ..