CD18

Summary

Gene Symbol: CD18
Description: integrin subunit beta 2
Alias: CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin beta-2, cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor), complement component 3 receptor 3 and 4 subunit, complement receptor C3 beta-subunit, integrin beta chain, beta 2, integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), leukocyte cell adhesion molecule CD18, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
Species: human

Top Publications

  1. ncbi Monoclonal antibodies against porcine LFA-1: species cross-reactivity and functional effects of beta-subunit-specific antibodies
    J E Hildreth
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205
    Mol Immunol 26:883-95. 1989
  2. ncbi [Left coronaro-ventricular fistula after myocardial infarction. Apropos of a case]
    D Agostini
    Service de soins intensifs de cardiologie, , Caen
    Arch Mal Coeur Vaiss 85:373-6. 1992
  3. ncbi [Myocardial bridging on the left anterior descending coronary artery and sudden death. Apropos of 19 cases with autopsy]
    P Desseigne
    Laboratoire d'Anatomie Pathologique, , Lyon
    Arch Mal Coeur Vaiss 84:511-6. 1991
  4. ncbi The relation between supraventricular tachyarrhythmias and left ventricular dysfunction after acute myocardial infarction
    M Zoni Berisso
    Divisione di Cardiologia, Ospedali Galliesa, Genova
    Acta Cardiol 43:689-701. 1988
  5. ncbi [Elastic recoil after transluminal coronary angioplasty; implications of clinical and angiographic data]
    J Boschat
    Service de cardiologie, CHU Morvan, Brest
    Arch Mal Coeur Vaiss 87:1663-9. 1994
  6. ncbi Physical and functional association of LFA-1 with DNAM-1 adhesion molecule
    K Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, Center for TARA, University of Tsukuba, Japan
    Immunity 11:615-23. 1999
  7. ncbi JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes
    Georg Ostermann
    Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany
    Nat Immunol 3:151-8. 2002
  8. ncbi Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins
    Minsoo Kim
    CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 301:1720-5. 2003
  9. pmc Two-dimensional kinetics of beta 2-integrin and ICAM-1 bindings between neutrophils and melanoma cells in a shear flow
    Shile Liang
    Dept of Bioengineering, The Pennsylvania State University, University Park, PA 16802 6804, USA
    Am J Physiol Cell Physiol 294:C743-53. 2008
  10. pmc Structure of an integrin with an alphaI domain, complement receptor type 4
    Can Xie
    Department of Pathology, Harvard Medical School, Immune Disease Institute and Children s Hospital, Boston, MA 02115, USA
    EMBO J 29:666-79. 2010

Research Grants

  1. ISOLATED PSGL-1 AND MAC-1 ADHESION TO ENDOTHELIUM
    DOUGLAS GOETZ; Fiscal Year: 2003
  2. Paul S Frenette; Fiscal Year: 2016
  3. SCOTT IRWIN SIMON; Fiscal Year: 2015
  4. M Amin Arnaout; Fiscal Year: 2016
  5. Protein-mediated molecular adhesion: AFM studies
    VINCENT MOY; Fiscal Year: 2006
  6. T CELL ADHESION MOLECULES IN MURINE LUPUS PNEUMONITIS
    Jeffrey Curtis; Fiscal Year: 2002
  7. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
  8. MMPs, Integrins and Microglial activation in HAND
    KATHLEEN ANNE MAGUIRE-ZEISS; Fiscal Year: 2013
  9. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2012
  10. Beta2 Integrin Activation and Signaling
    Vineet Gupta; Fiscal Year: 2010

Detail Information

Publications1290 found, 100 shown here

  1. ncbi Monoclonal antibodies against porcine LFA-1: species cross-reactivity and functional effects of beta-subunit-specific antibodies
    J E Hildreth
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205
    Mol Immunol 26:883-95. 1989
    ..to the human alpha-subunits of LFA-1 (CD11a), Mac-1 (CD11b) and LeuM5 (CD11c), and their common beta-subunit (CD18)...
  2. ncbi [Left coronaro-ventricular fistula after myocardial infarction. Apropos of a case]
    D Agostini
    Service de soins intensifs de cardiologie, , Caen
    Arch Mal Coeur Vaiss 85:373-6. 1992
    ..with anterior wall infarction treated by fibrinolysis and by angioplasty of the left anterior descending artery (LAD) 48 hours later...
  3. ncbi [Myocardial bridging on the left anterior descending coronary artery and sudden death. Apropos of 19 cases with autopsy]
    P Desseigne
    Laboratoire d'Anatomie Pathologique, , Lyon
    Arch Mal Coeur Vaiss 84:511-6. 1991
    ..macroscopic and histological features of 19 cases of myocardial bridging of the left anterior descending artery (LAD) out of a series of 930 medicolegal autopsy studies. The patients (15 men and 4 women) had an average age of 39...
  4. ncbi The relation between supraventricular tachyarrhythmias and left ventricular dysfunction after acute myocardial infarction
    M Zoni Berisso
    Divisione di Cardiologia, Ospedali Galliesa, Genova
    Acta Cardiol 43:689-701. 1988
    ..Age, left atrial dimension (LAD), cardio-thoracic ratio (CTR) and left ventricular ejection fraction (LVEF) at rest differed significantly among ..
  5. ncbi [Elastic recoil after transluminal coronary angioplasty; implications of clinical and angiographic data]
    J Boschat
    Service de cardiologie, CHU Morvan, Brest
    Arch Mal Coeur Vaiss 87:1663-9. 1994
    ..This appeared to be greater than the RC (1.06 +/- 0.30 mm) with respect to the Cx (0.86 +/- 0.23: p < 0.02) or LAD (0.92 +/- 0.25 mm: p < 0.04)...
  6. ncbi Physical and functional association of LFA-1 with DNAM-1 adhesion molecule
    K Shibuya
    Department of Immunology, Institute of Basic Medical Sciences, Center for TARA, University of Tsukuba, Japan
    Immunity 11:615-23. 1999
    ..In addition, cross-linking of LFA-1 induces tyrosine phosphorylation of DNAM-1, for which the Fyn protein tyrosine kinase is responsible. These results indicate that DNAM-1 is involved in the LFA-1-mediated intracellular signals...
  7. ncbi JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes
    Georg Ostermann
    Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany
    Nat Immunol 3:151-8. 2002
    ..Thus, JAM-1 is a counter-receptor for LFA-1 that is ideally situated to guide and control transmigration during leukocyte recruitment...
  8. ncbi Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins
    Minsoo Kim
    CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 301:1720-5. 2003
    ....
  9. pmc Two-dimensional kinetics of beta 2-integrin and ICAM-1 bindings between neutrophils and melanoma cells in a shear flow
    Shile Liang
    Dept of Bioengineering, The Pennsylvania State University, University Park, PA 16802 6804, USA
    Am J Physiol Cell Physiol 294:C743-53. 2008
    ..These findings provide new quantitative understanding of the biophysical basis of leukocyte-tumor cell interactions mediated by specific receptor-ligand interactions under shear flow conditions...
  10. pmc Structure of an integrin with an alphaI domain, complement receptor type 4
    Can Xie
    Department of Pathology, Harvard Medical School, Immune Disease Institute and Children s Hospital, Boston, MA 02115, USA
    EMBO J 29:666-79. 2010
    ..Differences among 10 molecules in crystal lattices provide unprecedented information on interdomain flexibility important for modelling integrin extension and activation...
  11. pmc Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins
    Lu Wang
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
    Immunity 32:518-30. 2010
    ..These results provide an indirect mechanism of cross-inhibition of TLRs and delineate a signaling pathway important for deactivation of macrophages...
  12. doi The lymphoid chemokine CCL21 triggers LFA-1 adhesive properties on human dendritic cells
    Christina Eich
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Immunol Cell Biol 89:458-65. 2011
    ..A thorough understanding of the adhesive events during the DC life cycle will help to improve the outcome of DC-based antitumor clinical trials...
  13. pmc CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1
    R Michael Gower
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Arterioscler Thromb Vasc Biol 31:160-6. 2011
    ..Involvement of β(2)-integrin CD11c/CD18 in atherogenesis was recently shown in dyslipidemic mice, which motivates our study of its inflammatory function ..
  14. doi Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state
    Sara W Feigelson
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 185:7394-404. 2010
    ....
  15. doi The insider's guide to leukocyte integrin signalling and function
    Nancy Hogg
    Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, UK
    Nat Rev Immunol 11:416-26. 2011
    ..This Review focuses on the integrin lymphocyte function-associated antigen 1 (LFA1; also known as αLβ2 integrin), which is expressed by T cells, and explores how disparate signalling pathways synergize to regulate LFA1 activity...
  16. pmc Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design
    Bhuvaneshwari Mahalingam
    Structural Biology Program, Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 187:6393-401. 2011
    ..As with other ligand-mimetic integrin antagonists, the function-blocking mAb 107 binds MIDAS of integrin CD11b/CD18 A domain (CD11bA), but in contrast, it favors the inhibitory Ca(2+) ion over the Mg(2+) ion at MIDAS...
  17. ncbi Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity
    E Bianchi
    Scientific Institute San Raffaele DIBIT, Milano, Italy
    Nature 404:617-21. 2000
    ..We suggest that signalling through the LFA-1 integrin may affect c-Jun-driven transcription by regulating JAB1 nuclear localization. This represents a new pathway for integrin-dependent modulation of gene expression...
  18. pmc beta1 and beta2 integrins activate different signalling pathways in monocytes
    Merit Reyes-Reyes
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas UNAM, Apto Postal 70228, Cd Universitaria, Mexico D F 04510, Mexico
    Biochem J 363:273-80. 2002
    ..These data suggest that distinct integrins activate different signalling pathways in monocytic cells...
  19. ncbi Signaling through integrin LFA-1 leads to filamentous actin polymerization and remodeling, resulting in enhanced T cell adhesion
    Joanna C Porter
    Leukocyte Adhesion Laboratory, Cancer Research U K London Research Institute, London, United Kingdom
    J Immunol 168:6330-5. 2002
    ..The findings demonstrate that LFA-1 acts not only as an adhesion receptor but also as a signaling receptor by actively initiating the F-actin reorganization that is essential for many T cell-dependent processes...
  20. ncbi The fourth blade within the beta-propeller is involved specifically in C3bi recognition by integrin alpha M beta 2
    Yang Li
    Department of Vascular Biology, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:34395-402. 2003
    ....
  21. pmc Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin alphaXbeta2
    Thomas Vorup-Jensen
    Center for Blood Research Institute for Biomedical Research, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:1614-9. 2005
    ..The observations suggest that the pericellular proteolysis at the leading edge of neutrophils not only facilitates passage through the extracellular matrix but also manufactures binding sites for alphaXbeta2...
  22. ncbi Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering
    Christopher W Cairo
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 25:297-308. 2006
    ..Our results suggest that current models of LFA-1 regulation are incomplete and that LFA-1 confinement by cytoskeletal attachment regulates cell adhesion both negatively and positively...
  23. ncbi Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin
    Sotirios N Sotiriou
    Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland 20892, USA
    FASEB J 20:559-61. 2006
    ..These observations suggest a novel mechanism for the atherogenic properties of Lp(a)...
  24. ncbi Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage
    N J Fardon
    Department of Medicine, University of Newcastle-upon-Tyne, United Kingdom
    Am J Hypertens 14:927-33. 2001
    ..Neutrophil accumulation, which occurs by beta2-integrin (CD11b/CD18) expression, followed by release of proinflammatory factors from primary vesicles is an important factor in ..
  25. pmc P-selectin mediates neutrophil rolling on histamine-stimulated endothelial cells
    D A Jones
    Rice University, Houston, Texas 77251 1892
    Biophys J 65:1560-9. 1993
    ..Anti-CD54 MAb R6.5 and anti-CD18 MAb R15...
  26. pmc Induction of CD18-mediated passage of neutrophils by Pasteurella haemolytica in pulmonary bronchi and bronchioles
    M R Ackermann
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011 1250, USA
    Infect Immun 67:659-63. 1999
    ..haemolytica pneumonia are poorly characterized. To determine whether the CD18 family (beta2-integrin) of leukocyte adhesion molecules mediates initial passage of neutrophils into the pulmonary ..
  27. pmc Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators
    D T Walsh
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 114:1343-50. 1995
    ..v. with an anti-CD18 monoclonal antibody 6.5E F(ab')2 (2.5 mg kg-1). The oedema response was unaffected in these animals.6...
  28. pmc Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators
    M M Teixeira
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 113:1363-71. 1994
    ..5. The anti-CD18 monoclonal antibody, (mAb) 6...
  29. ncbi Effects of the AT1 receptor antagonist on adhesion molecule expression in leukocytes and brain microvessels of stroke-prone spontaneously hypertensive rats
    K Takemori
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Am J Hypertens 13:1233-41. 2000
    ..Thus, AII seems to be an important mediator for the hypertensive microvascular injuries...
  30. ncbi Regulation of leukocyte recruitment by polypeptides derived from high molecular weight kininogen
    T Chavakis
    Institute for Biochemistry, and, Third Department of Internal Medicine, Justus Liebig Universitat, Giessen, Germany
    FASEB J 15:2365-76. 2001
    ..behind a two-chain, high molecular weight kininogen (HKa) reported to bind to the beta2-integrin Mac-1 (CR3, CD11b/CD18, alphaMbeta2) on neutrophils and exert antiadhesive properties by binding to the urokinase receptor (uPAR) and ..
  31. ncbi Platelet/polymorphonuclear leukocyte adhesion: a new role for SRC kinases in Mac-1 adhesive function triggered by P-selectin
    P Piccardoni
    Department of Vascular Medicine and Pharmacology, G Bizzozero Laboratory of Blood and Vascular Cell Interactions, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Blood 98:108-16. 2001
    ..stimulated by P-selectin-IgG chimera, SRC kinase inhibition impaired Mac-1 clustering, F-actin accumulation, and CD18 redistribution to the cytoskeleton...
  32. ncbi Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis
    Daniel C Bullard
    Department of Genetics, University of Alabama at Birmingham, 35294, USA
    J Immunol 175:6327-33. 2005
    Mac-1 (CD18/CD11b) is a member of the beta2-integrin family of adhesion molecules and is implicated in the development of many inflammatory diseases...
  33. ncbi Cultured human thymocytes lacking CD2 and CD11a/CD18 antigens are functional and adhere to endothelial cells via CD56 or CDw49d molecules
    A Poggi
    Istituto Scientifico Tumori, Genova, Italy
    Cell Immunol 140:319-30. 1992
    The preferential growth of CD3-CD2-CD11a/CD18- thymocytes was obtained by stimulation of CD2-CD3- thymic cells with low doses of PMA (0.5 ng/ml) and subsequent culture in the presence of recombinant interleukin-2 (100 U/ml)...
  34. ncbi Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation
    L Petruzzelli
    Harvard Medical School, Center for Blood Research, Boston, MA 02115, USA
    J Immunol 160:4208-16. 1998
    ..By examining both ligand binding and aggregation, we have been able to dissect the signaling components critical in the multistep process of LFA-1-mediated cellular adhesion...
  35. pmc Aggravated Lyme carditis in CD11a-/- and CD11c-/- mice
    Mireia Guerau-de-Arellano
    Department of Pathology, Tufts University School of Medicine, Jaharis 512, 150 Harrison Ave, Boston, MA 02111, USA
    Infect Immun 73:7637-43. 2005
    b>CD18 hypomorph mice expressing reduced levels of the common beta2 integrin chain develop aggravated Lyme carditis, compared to that developed by wild-type (WT) mice, upon infection with the spirochete Borrelia burgdorferi...
  36. ncbi Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosis
    Jenny Jongstra-Bilen
    Cell Biology Program, Hospital for Sick Children and the Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 278:45720-9. 2003
    Functional interactions between Fcgamma-receptors (FcgammaR) and the beta2 integrin Mac-1 (CD11b/CD18) have been described, but the molecular basis of this relationship remains unclear...
  37. ncbi Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in beta2 integrin-deficient mice
    Thorsten Peters
    Department of Dermatology, and Allergic Diseases, University of Ulm, Maienweg 12, 89081 Ulm, Germany
    J Leukoc Biol 80:599-607. 2006
    Absence of the common beta chain (CD18) of beta(2) integrins leads to leukocyte-adhesion deficiency type-1 (LAD1) in humans...
  38. ncbi ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18
    Pratima Kodali
    Liver Center, University of California, CA 94110, USA
    Am J Physiol Gastrointest Liver Physiol 291:G355-63. 2006
    ..The objective of this study was to determine whether the beta2-integrin CD18, which plays an important role in leukocyte invasion and cytotoxicity, contributes to ANIT-induced hepatic ..
  39. ncbi Cross-linking of CD18 in human neutrophils induces an increase of intracellular free Ca2+, exocytosis of azurophilic granules, quantitative up-regulation of CD18, shedding of L-selectin, and actin polymerization
    B Walzog
    Department of Physiology, , Germany
    J Leukoc Biol 56:625-35. 1994
    ..PMN adhesion is largely dependent on the function of the beta 2 integrins, CD11a,b,c/CD18. We mimicked engagement of beta 2 integrins by antibody cross-linking of CD18 on isolated human PMNs using both ..
  40. ncbi Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase
    D Wang
    Department of Medicine, and Heart and Vascular Institute, Henry Ford Hospital, Detroit, Michigan 48202-2689, USA
    Am J Hypertens 12:174-82. 1999
    ..Myocardial infarction was induced by ligation of the left anterior descending coronary artery (LAD), and tissue was collected at selected times thereafter from both ligated and sham-operated rats...
  41. pmc Effect of duration of ischaemia on reduction of myocardial infarct size by inhibition of neutrophil accumulation using an anti-CD18 monoclonal antibody
    F M Williams
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 111:1123-8. 1994
    ..aim of this study was to examine whether inhibition of myocardial neutrophil infiltration, using an antibody to the CD18 leukocyte adhesion molecule, was effective in reducing infarct size in anaesthetized rabbits. 2...
  42. ncbi Adhesion receptors and cytokine profiles in controlled tourniquet ischaemia in the upper extremity
    G Germann
    Departments of Plastic, Hand and Burn Surgery, BG Trauma Centre, Ludwigshafen, Germany
    J Hand Surg Br 22:778-82. 1997
    ..Profiles of adhesion molecules (CD11/CD18), key cytokines (TNF-alpha and IL-1), CD4+ and CD8+ lymphocytes, and polymorphonuclear neutrophils were ..
  43. ncbi [Effect of erythromycin on neutrophil adhesion molecules]
    S Kusano
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Kansenshogaku Zasshi 67:7-11. 1993
    ..These findings indicate that EM does not directly reduce the expression of LFA-1 alpha, beta and Mac-1 on peripheral neutrophil obtained from healthy subjects...
  44. ncbi [Analysis of complement-mediated phagocytosis in systemic lupus erythematosus model mice, NZB/W F1]
    T Onogawa
    Department of Immunology and Pathology, School of Health Sciences, Kyorin University
    Kansenshogaku Zasshi 68:332-8. 1994
    ....
  45. ncbi Expression of adhesion molecules in the host response to colon carcinoma
    B F Banner
    Department of Pathology, University of Massachusetts Medical Center, Worcester 01655, USA
    Ultrastruct Pathol 19:113-8. 1995
    ....
  46. ncbi Selective in vivo growth of lymphocyte function- associated antigen-1-positive murine myeloma cells. Involvement of function-associated antigen-1-mediated homotypic cell-cell adhesion
    Kewal Asosingh
    Department of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Exp Hematol 31:48-55. 2003
    ..In this study we used the 5T experimental mouse model to analyze the involvement of LFA-1 in myeloma cell bone marrow homing, survival, and growth...
  47. pmc Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1
    Susan M Keating
    Department of BioAnalytical Research and Development, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Protein Sci 15:290-303. 2006
    ..This binding site overlaps with the ICAM-1 binding site on the alpha subunit of LFA-1, which has previously been localized to the I domain...
  48. ncbi Reduction of ICAM-1 and LFA-1-positive leukocytes in the perivascular space of arteries under mycophenolate mofetil therapy reduces rat heart transplant vasculopathy
    Markus Richter
    Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany
    J Heart Lung Transplant 23:1405-13. 2004
    ..We investigated the correlation between TVP and ICAM-1 expression and accumulation of LFA-1-positive leukocytes in the perivascular space (PVS) of arteries under different immunosuppressive drugs...
  49. ncbi Transfection of non-susceptible cells with Ovis aries recombinant lymphocyte function-associated antigen 1 renders susceptibility to Mannheimia haemolytica leukotoxin
    Paulraj K Lawrence
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Vet Microbiol 125:91-9. 2007
    ..Although it is certain that CD18, the beta subunit of beta(2) integrins, mediates Lkt-induced cytolysis of leukocytes, it is not clear whether CD18 ..
  50. pmc Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation
    T B Issekutz
    Department of Medicine, University of Toronto, Ontario, Canada
    J Exp Med 183:2175-84. 1996
    ..Neutrophil migration out of the blood in joint inflammation involves both the CD18 (beta2) integrins and a CD18 integrin-independent pathway...
  51. ncbi [Study on lymphocyte-response in early stage of respiratory infection--a view point from experimental Klebsiella pneumoniae pneumonia]
    H Watanaba
    First Department of Internal Medicine, Kyorin University School of Medicine
    Kansenshogaku Zasshi 66:696-708. 1992
    ..2. Such a rapid increase in lymphocytes in BALF in mature group depended on L3T4-Ly6c cells and L3T4-LFA 1 cells. These cells in juvenile group were not accumulated in BALF at initial phase of the infection...
  52. ncbi Mechanical strain stimulates a mitogenic response in coronary vascular smooth muscle cells via release of basic fibroblast growth factor
    K Sudhir
    Baker Medical Research Institute, Alfred Hospital, Prahran, Victoria, Australia
    Am J Hypertens 14:1128-34. 2001
    ..Vascular smooth muscle cells were cultured from explants of left anterior descending (LAD) coronary arteries from young sheep...
  53. pmc Role of CD18 in the accumulation of eosinophils and neutrophils and local oedema formation in inflammatory reactions in guinea-pig skin
    M M Teixeira
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 111:811-8. 1994
    ..Monoclonal antibodies to the leukocyte adhesion molecule CD11/CD18 block neutrophil accumulation and prevent neutrophil-dependent oedema formation...
  54. ncbi Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry
    Matthew P Crump
    School of Biological Sciences, University of Southampton, Bassett Crescent East, UK
    Biochemistry 43:2394-404. 2004
    ..Models from the NMR data were assessed by comparison to an X-ray crystallographic structure of the complex, confirming that the method correctly predicted the essential features of the bound ligand...
  55. ncbi Complete left bundle branch block with left QRS axis deviation: defining its clinical importance
    G Parharidis
    1st Department of Cardiology, AHEPA General Hospital, Medical School, Aristotle University of Thessaloniki, Greece
    Acta Cardiol 52:295-303. 1997
    Aim of this study was to elucidate the diagnostic significance of left axis deviation (LAD) in patients (pts) with chronic (> 6 months) left bundle branch block (LBBB)...
  56. ncbi LFA-1 expression by blood eosinophils is increased in atopic asthmatic children and is involved in eosinophil locomotion
    S Lantero
    Pulmonary Division, G Gaslini Institute, Genoa, Italy
    Eur Respir J 12:1094-8. 1998
    ..and nine controls were studied and the expression of lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18), Mac-1 (CD11b/CD18) and very late antigen-4 (VLA-4; CD49d/CD29) on blood eosinophils was evaluated by specific ..
  57. pmc Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domains
    K S Weber
    Institut für Prophylaxe der Kreislaufkrankheiten, Ludwig Maximilians Universitat, D 80336 MUnchen, Germany
    Mol Biol Cell 10:861-73. 1999
    ..Our data suggest that a specific regulation of beta2 integrin avidity by chemokines may be important in leukocyte extravasation and may be triggered by distinct activation pathways transduced via the alpha subunit cytoplasmic domains...
  58. ncbi Cellular adhesion molecules in rat adjuvant arthritis
    M M Halloran
    Northwestern University Medical School, Chicago, Illinois 60611, USA
    Arthritis Rheum 39:810-9. 1996
    ..To examine adhesion molecule expression during the progression of inflammation in a rheumatoid arthritis model of adjuvant-induced arthritis (AIA) in rats...
  59. ncbi Increased expression of neutrophil and monocyte adhesion molecules LFA-1 and Mac-1 and their ligand ICAM-1 and VLA-4 throughout the acute phase of myocardial infarction: possible implications for leukocyte aggregation and microvascular plugging
    S R Meisel
    Department of Cardiology, Sackler School of Medicine, Tel Aviv University, Israel
    J Am Coll Cardiol 31:120-5. 1998
    ..This mechanism may facilitate the occurrence of the "no-reflow" phenomenon or slow coronary filling after acute myocardial infarction...
  60. ncbi Contributions of LFA-1 and Mac-1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusion
    Thiruma V Arumugam
    Dept of Molecular and Cellular Physiology, Louisiana State Univ Health Sciences Center, 1500 Kings Highway, Shreveport, LA 71130, USA
    Am J Physiol Heart Circ Physiol 287:H2555-60. 2004
    ..These findings indicate that both alpha-subunits of the beta2-integrins contribute to the brain injury and blood cell-vessel wall interactions that are associated with transient focal cerebral ischemia...
  61. ncbi Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter
    A Nueda
    Unidad de Biologia Molecular, Hospital de la Princesa, Madrid, Spain
    J Biol Chem 268:19305-11. 1993
    ..with Mac-1 (CD11b/CD18, alpha M/beta 2) and p150,95 (CD11c/CD18, alpha X/beta 2), constitutes the leukocyte integrin beta 2 (CD18) subfamily...
  62. pmc LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ
    Ronen Sumagin
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 185:7057-66. 2010
    ..Using function-blocking Abs, we show that these different crawling patterns were due to CD11a/CD18 (LFA-1)- versus CD11b/CD18 (Mac-1)-mediated crawling...
  63. ncbi [Response of the coronary arteries to cold test and flow velocity increase is improved by deferoxamine but not by L-arginine in diabetic patients]
    A Nitenberg
    Service de Physiologie et d'Explorations Fonctionnelles, INSERM U 426, , Colombes
    Arch Mal Coeur Vaiss 90:1037-41. 1997
    ..Dimensions of the proximal LAD (pLAD) were measured by quantitative angiography...
  64. ncbi Leukocyte-cell adhesion: a molecular process fundamental in leukocyte physiology
    M Patarroyo
    Dept of Immunology, Karolinska Institutet, Stockholm, Sweden
    Immunol Rev 114:67-108. 1990
    ..assay and blocking monoclonal antibodies, several CAMs have been identified, namely the Leu-CAM family (CD11a-c/CD18) and ICAM-1 (CD54)...
  65. ncbi 1H-cyclopenta[b]benzofuran lignans from Aglaia species inhibit cell proliferation and alter cell cycle distribution in human monocytic leukemia cell lines
    F I Bohnenstengel
    Department of Pharmaceutical Biology, Julius von Sachs Institute of Biosciences, , Germany
    Z Naturforsch C 54:1075-83. 1999
    ..Our data suggests that 1H-cyclopenta[b]benzofuran lignans of the rocaglamide type act primarily by a cytostatic mechanism...
  66. ncbi [Effects of Staphylococcus aureus protein A on the production of primary host defense factors against S. aureus infection]
    N Endo
    Department of Immunology, Kyorin University School of Health Sciences
    Kansenshogaku Zasshi 71:39-45. 1997
    ..Increase of Fn production of M phi by PA stimulation may play an important role in the primary host defense against S. aureus infection...
  67. pmc Transfection of cells from patients with leukocyte adhesion deficiency with an integrin beta subunit (CD18) restores lymphocyte function-associated antigen-1 expression and function
    M L Hibbs
    Center for Blood Research, Boston, Massachusetts 02115
    J Clin Invest 85:674-81. 1990
    Leukocyte adhesion deficiency (LAD) is an inherited immunodeficiency disease that is characterized by the deficient expression of the leukocyte adhesion glycoproteins lymphocyte function-associated antigen-1 (LFA-1), Mac-1, and p150,95...
  68. ncbi CD11a/CD18 (LFA-1) epitopes involved in syncytium formation among CD4+ T-cells following cell free HIV-1 infection
    J Goudsmit
    Human Retrovirus Laboratory, Department of Virology, Amsterdam, The Netherlands
    Viral Immunol 3:289-93. 1990
    ..antibodies to epitopes localized at the top of the alpha-subunit (CD11a) and at the stem of the beta-subunit (CD18) of the lymphocyte function associated antigen-1 (LFA-1) block syncytium formation when added to CD4+ T-cells ..
  69. ncbi Sequential flow cytometric analysis of cell-cycle related changes in LFA-1 (CD18/CD11a) expression by trisomy 21 (Down's syndrome) lymphoblastoid cells
    B P McMurray
    Department of Medical Genetics, St Mary s Hospital, Manchester
    Cell Tissue Kinet 22:223-33. 1989
    ..antigen 1 (LFA-1) is a heterodimeric leucocyte adhesion molecule comprising non-covalently associated 95 kD, CD18 and 180 kD, CD11a subunits...
  70. ncbi Modulation, in vivo and in vitro, of surface expression of CD18 by bovine neutrophils
    R O Gilbert
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
    Am J Vet Res 53:1675-8. 1992
    A series of experiments was designed to elucidate some of the factors that may influence surface expression of CD18 by bovine neutrophils. Expression of CD18 was determined by immunofluorescence flow cytometry...
  71. ncbi Impaired transendothelial migration by neonatal neutrophils: abnormalities of Mac-1 (CD11b/CD18)-dependent adherence reactions
    D C Anderson
    Department of Pediatrics, Baylor College of Medicine, Houston, TX
    Blood 76:2613-21. 1990
    In order to evaluate the functions of lymphocyte function antigen-1 (LFA-1) (CD11a/CD18) and Mac-1 (CD11b/CD18) on neonatal neutrophils, we examined neutrophil adhesion to and migration through human umbilical vein endothelial cell (HUVEC)..
  72. ncbi Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1
    M A Jutila
    Department of Pathology, Stanford University Medical Center, CA 94305
    J Immunol 143:3318-24. 1989
    ..These results confirm that both the MEL-14 antigen and Mac-1/LFA-1 are important in neutrophil localization to inflamed sites in vivo, but suggest that their roles in endothelial cell interactions are distinct...
  73. pmc Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice
    Francis X Pizza
    Dept of Kinesiology, The University of Toledo, 2801 W Bancroft Street, Toledo, OH 43606, USA
    J Physiol 562:899-913. 2005
    ..that: (1) neutrophil accumulation after contraction-induced muscle injury is dependent on the beta(2) integrin CD18, (2) neutrophils contribute to muscle injury and oxidative damage after contraction-induced muscle injury, and (3) ..
  74. ncbi [Detection of coronary restenosis using myocardial tomoscintigraphy with thallium 201. A series of 85 cases]
    J R Lusson
    Cardiologie, Hopital Saint Jacques, Clermont Ferrand
    Arch Mal Coeur Vaiss 82:1679-83. 1989
    ..Angioplasty had been performed on a single vessel (LAD in 57 cases, right in 18 cases and CX in 10 cases). After 6.4 +/- 1...
  75. ncbi Mannheimia (Pasteurella) haemolytica leukotoxin utilizes CD18 as its receptor on bighorn sheep leukocytes
    Weiguo Liu
    Department of Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Wildl Dis 43:75-81. 2007
    ..Previously, we have shown that CD18, the beta subunit of beta2 integrins, serves as the receptor for Lkt on bovine leukocytes...
  76. ncbi Natural killer cells and B lymphocytes in L-selectin and Mac-1/LFA-1 knockout mice: marker-dependent, but not cell lineage-dependent changes in the spleen and bone marrow
    Duncan Lejtenyi
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Immunobiology 207:129-35. 2003
    ..the aim of the present study to quantify, in knock-out mice deficient for either the L-selectin addressin, or the CD18:Mac-1/LFA-1 integrins, NK cells and B cells in both the spleen and their bone marrow birth site...
  77. pmc VLA-4 integrin can mediate CD11/CD18-independent transendothelial migration of human monocytes
    H E Chuluyan
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    J Clin Invest 92:2768-77. 1993
    ..7 or 60.3) to CD18 of the CD11/CD18 complex on the monocyte. However, when the HUVE was pretreated for 5 h with IL-1 alpha (0...
  78. ncbi Lipid metabolism in lipoatrophic diabetes
    G Enzi
    Department of Internal Medicine, University of Padua, Italy
    Horm Metab Res 20:587-91. 1988
    Some aspects of lipid metabolism were studied in 4 patients with a congenital lipoatrophic diabetes (LAD) associated to a type IV hyperlipoproteinemia...
  79. ncbi [8 years outcome of 243 trials of coronary angiography performed in the Montreal Institute of Cardiology]
    P Brunel
    Service de Radiologie Thoracique, , Nantes
    Arch Mal Coeur Vaiss 86:867-72. 1993
    ..One segment was dilated in 216 patients and 2 segments in 27 patients. The LAD was dilated in 179 patients, the right coronary in 63 and the left circumflex artery in 20 patients...
  80. ncbi [Cardiac factors predictive of 10-year survival after coronary surgery]
    G Fournial
    Service de chirurgie cardiovasculaire B, , CHU de Toulouse
    Arch Mal Coeur Vaiss 92:851-8. 1999
    ..Cardiac survival at 10 years was significantly better after internal mammary-LAD bypass: 91.4% (CI 87.1-95.1) than after saphenous vein bypass grafting alone: 79.6% (CI 74.8-84.4) (p = 0.012)...
  81. ncbi Differential roles of VLA-4(CD49d/CD29) and LFA-1(CD11a/CD18) integrins and E- and P-selectin during developing and established active or adoptively transferred adjuvant arthritis in the rat
    Andrew C Issekutz
    Departments of Pediatrics, Pathology and Microbiology Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    Immunol Cell Biol 81:397-408. 2003
    ..on P-selectin plus VLA-4 (alpha4B1) and neutrophil recruitment depended (> 80%) on P-selectin plus LFA-1 (CD11a/CD18). E-selectin played a minimal role in inflammatory cell recruitment to the already inflamed joint...
  82. ncbi [Effects of intracoronary injection of SIN-1 on vasoconstriction of epicardial arteries induced by acetylcholine]
    J L Dubois-Rande
    Service de cardiologie, CHU Henri Mondor et INSERM U2, Creteil
    Arch Mal Coeur Vaiss 86:881-7. 1993
    ..Twelve patients with left anterior descending artery (LAD) disease were studied...
  83. ncbi [Use of the radial artery for coronary artery bypass. A new experience after 20 years]
    C Acar
    , , Paris
    Arch Mal Coeur Vaiss 86:1683-9. 1993
    ..The target artery receiving the RA was: circumflex (n = 93), diagonal (n = 39), right coronary (n = 47) and LAD (n = 10). Two patients died (1.3%) and three presented a perioperative myocardial infarct (2.5%)...
  84. ncbi Six months clinical, angiographic, and IVUS follow-up after PTFE graft stent implantation in native coronary arteries
    G Lukito
    Department of Cardiology, Heart Center Hasselt, Virga Jesse Hospital, Belgium
    Acta Cardiol 55:255-60. 2000
    ..RESULTS : The coronary arteries treated were: RCA in 7 patients, LCX in 2 patients, LAD in 1 patient. Mean balloon size was 3.7 mm diameter, and mean inflation pressure was 18 atm (min. 12, max. 23)...
  85. pmc Polymorphonuclear leucocyte migration through human dermal fibroblast monolayers is dependent on both beta 2-integrin (CD11/CD18) and beta 1-integrin (CD29) mechanisms
    J X Gao
    Department of Pediatrics, Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    Immunology 85:485-94. 1995
    ..was partially inhibited (35-70%, depending on the stimulus) by treatment of PMNL with monoclonal antibody (mAb) to CD18 (beta 2-integrins). Most of the CD18-independent migration was inhibited by mAb to beta 1-integrins (CD29)...
  86. ncbi Effect of short-term cocaine administration on the immune system of young and old C57BL/6 female mice
    L L Colombo
    Arizona Prevention Center, College of Medicine, University of Arizona, Tucson 85724, USA
    Immunopharmacol Immunotoxicol 21:755-69. 1999
    ..Cocaine only decreased the absolute number of Thy 1+, CD4+, CD8+, IL-2R+, Mac 1+ and B cells, in the spleen of old mice...
  87. ncbi Non-phagocytic adherent cells as contaminants in peritoneal macrophage cultures from conventionally housed mice
    B Johne
    Institute of Microbiology, Dental Faculty, University of Oslo, Norway
    Acta Pathol Microbiol Immunol Scand C 95:233-9. 1987
    ..The rise in NPAC parallelled the activation of macrophages and may therefore serve as an indication of the functional state of the macrophage cultures...
  88. ncbi [Restoration of normal coronary vasomotricity after intravenous infusion of angiotensin converting-enzyme inhibitor (perindoprilat) in hypertensive patients]
    I Antony
    Service d'Explorations Fonctionnelles, INSERM U251, , Colombes
    Arch Mal Coeur Vaiss 88:1125-8. 1995
    ..Diameter changes of proximal left anterior descending coronary artery (pLAD) and coronary flow velocity in distal LAD have been measured at baseline, during CPT, during recontrol, and after 10 mg papaverine (PAP) injection in the mid ..
  89. ncbi Early detection of left ventricular aneurysm rupture by two-dimensional echocardiography and surgical salvage
    O Yesildag
    Department of Cardiology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey
    Acta Cardiol 48:385-93. 1993
    ..patent and there was minimal stenosis (lesser than 50%) at the proximal 1/3 portion of left anterior descending (LAD) artery. Left ventriculography showed anterolateral and posterolateral hypokinesis...
  90. ncbi Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis
    P A Regidor
    Department of Gynecology, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Gynecol Endocrinol 15:202-9. 2001
    ..The primary objective of this study was to compare the efficacy of the GnRH-agonist leuprorelin acetate depot (LAD) (Enantone-Gyn) 3...
  91. ncbi [Reciprocal changes in the ST segment in acute inferior myocardial infarction. Value of delay in appearance]
    P Geslin
    Service de cardiologie, CHU, Angers
    Arch Mal Coeur Vaiss 80:1161-9. 1987
    ..001) when the left anterior descending artery (LAD) was not involved than when it was involved; (b) there was no difference between patients with and without ST ..
  92. ncbi Peptides derived from the complementarity-determining regions of anti-Mac-1 antibodies block intercellular adhesion molecule-1 interaction with Mac-1
    Y Feng
    Scios Inc, Sunnyvale, California 94086, USA
    J Biol Chem 273:5625-30. 1998
    ..1 CDR peptide with five residues randomized, we were able to identify a novel peptide inhibitor of Mac-1 with substitutions at all five positions. These peptides provide lead structures for development of Mac-1 antagonists...
  93. ncbi [Myocardial infarction caused by acute left main coronary artery occlusion. Apropos of 4 cases and review of the literature]
    M Gilard
    , centre hospitalier de la Cavale Blanche, Brest
    Arch Mal Coeur Vaiss 90:1277-83. 1997
    ..in the 4 cases: significant stenoses were discovered after recanalisation, on the left anterior descending artery (LAD) in 2 cases and the circumflex or marginal arteries in 3 cases...
  94. ncbi Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow
    Aaron F H Lum
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    J Biol Chem 277:20660-70. 2002
    ..acute inflammation is triggered by G-protein-linked chemotactic receptors that in turn activate beta(2) integrin (CD18), deemed a critical step in facilitating cell capture and arrest under the shear force of blood flow...
  95. ncbi [Post-traumatic fistula of the left anterior descending coronary artery and left ventricle. Apropos of a new case]
    F Collet
    Service de cardiologie, Centre Cardio-Vasculaire, Marseille
    Arch Mal Coeur Vaiss 83:267-70. 1990
    ..Color Doppler flow studies showed a mosaic pattern opposite a dilated left anterior descending (LAD) artery. These signs of LAD-LV fistula with a single orific were confirmed at coronary arteriography...
  96. ncbi Impact of delayed reperfusion of myocardial hibernation on myocardial ultrastructure and function and their recoveries after reperfusion in a pig model of myocardial hibernation
    C Chen
    Division of Cardiology, Hartford Hospital, Hartford, CT, USA
    Cardiovasc Pathol 9:67-84. 2000
    ..This study examined the effect of delayed reperfusion of myocardial hibernation from 24 hours to 7 days on myocardial ultrastructural and functional changes and their recoveries after reperfusion...
  97. ncbi [Diagnostic value of exercise tomoscintigraphy with thallium 201 in patients with complete left branch block]
    G Tessonnier
    Service de cardiologie, CHU Timone, Marseille
    Arch Mal Coeur Vaiss 82:209-13. 1989
    ..exercise scintigrams, but in only 4 of them did the coronary disease involve the left anterior descending artery (LAD) (n = 3) or the left main coronary artery (n = 1)...
  98. ncbi [Immediate or delayed angioplasty during the acute phase of myocardial infarction. Apropos of 118 cases]
    G Grollier
    Service des soins intensifs de cardiologie, , Caen
    Arch Mal Coeur Vaiss 83:159-66. 1990
    ..of failed angioplasties occurred in patients with occluded arteries, the majority being left anterior descending (LAD) arteries (71.4%). The incidence of restenosis was 13.4 per cent...
  99. ncbi Inducible accessory function of a macrophage cell line
    F B Aiello
    Biological Carcinogenesis and Development Program, Program Resources Inc./DynCorp, NCI-Frederick Cancer Research and Development Center, MD
    Immunopharmacol Immunotoxicol 15:327-53. 1993
    ..The expression of ICAM-1 and LFA-1 was increased during activation and anti-LFA-1 antibody blocked APC function. This suggests that one important feature of the activation process may be improvement of cellular adhesion...
  100. ncbi [Angioplasty of the proximal left anterior descending artery outside the acute phase of myocardial infarction. Apropos of a series of 100 consecutive patients]
    J M Maillard
    Clinique cardiologique, , Tours
    Arch Mal Coeur Vaiss 89:825-33. 1996
    ..of percutaneous transluminal coronary angioplasty (PTCA) of the proximal left anterior descending artery (LAD 1) must take into consideration the importance of the threatened myocardial territory in case of complications and ..
  101. ncbi Natural killer (NK) cell generation in bone marrow cultures: role of IL-1 alpha
    E Ayroldi
    Institute of Pharmacology, University of Perugia
    Immunopharmacol Immunotoxicol 13:589-606. 1991
    ....

Research Grants64

  1. ISOLATED PSGL-1 AND MAC-1 ADHESION TO ENDOTHELIUM
    DOUGLAS GOETZ; Fiscal Year: 2003
    ..First, we have proposed and found evidence for the hypothesis that beta2 integrin (specifically Mac-1 (CDllb/CD18)) - E-selectin molecular interactions play a role in leukocyte adhesion to the endothelium...
  2. Paul S Frenette; Fiscal Year: 2016
    ..These studies will provide new insight on the mechanisms regulating sickle cell VOC and lead to novel ways to target inflammation. ..
  3. SCOTT IRWIN SIMON; Fiscal Year: 2015
    ....
  4. M Amin Arnaout; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The beta2 integrin CD11b/CD18, the most abundant leukocyte integrin, is normally kept in an inactive (low affinity) state on circulating neutrophils and monocytes...
  5. Protein-mediated molecular adhesion: AFM studies
    VINCENT MOY; Fiscal Year: 2006
    ..abstract_text> ..
  6. T CELL ADHESION MOLECULES IN MURINE LUPUS PNEUMONITIS
    Jeffrey Curtis; Fiscal Year: 2002
    ..Treatment with DNA MTase inhibitors increases expression of the Beta2 integrin LFA-1 (CD11a/CD18). T cells transfected with CD18 are also autoreactive and induce lupus on transfer to syngeneic mice...
  7. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..This could lead to the identification of targeted therapeutic strategies that attenuate organ injury while minimally immunocompromising the host. ..
  8. MMPs, Integrins and Microglial activation in HAND
    KATHLEEN ANNE MAGUIRE-ZEISS; Fiscal Year: 2013
    ..Further study of the receptors that underlie MMP dependent effects is also clinically relevant. At least one soluble CAM can interact with LFA-1, a microglial integrin for which a clinically tolerable antagonist has been developed. ..
  9. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2012
    ..In our previous studies, we determined that the C. elegans L1CAMs, LAD-2 and LAD-1/SAX-7 function respectively in axon guidance and maintaining nervous system integrity...
  10. Beta2 Integrin Activation and Signaling
    Vineet Gupta; Fiscal Year: 2010
    ..develop and test specific, structure-based hypotheses for integrin activation, with a focus on beta2 integrin CD11b/CD18, by using alphaVbeta3 structure as the model for the CD11b/CD18 integrin...
  11. MOLECULAR MODELS OF IMMUNE-MEDIATED VASCULAR INJURY
    Jeffrey R Bender; Fiscal Year: 2012
    ..We have demonstrated that, upon engagement, lymphocyte function-associated antigen-1 (LFA-1,aL[unreadable]2, CD11a/CD18) generates signals leading to stabilization of Th1 cytokine transcripts including those encoding IFN-?, TNF-a and ..
  12. HTS Assay for Discovery:Small Molecule Regulators (RMI)
    Vineet Gupta; Fiscal Year: 2005
    ..The CD11b/CD18 (alpha-M-beta2) heterodimer is the predominant beta2 integrin receptor in neutrophils and macrophages and mediates ..
  13. CD11B/CD18 AND NEUTROPHIL EPITHELIAL INTERACTIONS
    CHARLES PARKOS; Fiscal Year: 2003
    ..we have shown that PMN transepithelial migration requires specific regions of the neutrophil beta2 integrin CD11b/CD18 and is independent of selectins and ICAM-1...
  14. THE REGULATION OF BETA-2 INTEGRIN FUNCTION
    LLOYD KLICKSTEIN; Fiscal Year: 2004
    ..A further understanding of how lymphocytes regulate adhesion will lead to new strategies for the development of anti-inflammatory therapies with potential applications in autoimmune disease and transplantation medicine. ..
  15. Minsoo Kim; Fiscal Year: 2015
    ..The integrin lymphocyte function-associated antigen-1 (LFA- 1 or aLb2;CD11a/CD18) is expressed on most leukocytes and plays a major role in regulating leukocyte adhesion and recruitment to damaged ..
  16. LYMPHOCYTE FUNCTION ASSOCIATED ANTIGENS
    Timothy A Springer; Fiscal Year: 2013
    ..The molecular characterizationof LFA-1 and its antagonists proposed in this grant will enhance development of new drugs. ..
  17. Integrin LFA-1 antagonists
    Motomu Shimaoka; Fiscal Year: 2009
    ..importance of LFA-1 in host defense is demonstrated through deficiency of this molecule in an inherited disease, LAD-I...
  18. ROBERTO IRENARDO VAZQUEZ PADRON; Fiscal Year: 2015
    ..The integrin Mac-1 (also known as CD11b/CD18, CR3, and [unreadable]M[unreadable]2), which is primarily expressed on leukocytes, plays a key role in vascular ..
  19. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..g., heart attacks and strokes), as well as other organs and tissues of the body. These mechanistic insights may help identify novel therapeutic targets for the treatment of a broad spectrum of inflammatory diseases. ..
  20. Bordetella adenylate cyclase toxin: the role of cell interaction in toxin functio
    JOSHUA CLARK EBY; Fiscal Year: 2013
    ..The magnitude of intoxication correlates with the relative surface expression of the (32 integrin, CD11b/CD18, a receptor expressed most abundantly on neutrophils and macrophages;however, the relationship between AC toxin and ..
  21. Tanya N Mayadas; Fiscal Year: 2016
    ..Neutrophil Fc[unreadable]Rs and the leukocyte specific CD18 integrins cooperated to promote IC induced neutrophil slow rolling, adhesion and transmigration, and TNF priming of ..
  22. Inhibition of platelet-leukocyte interactions to treat TRALI
    Paul S Frenette; Fiscal Year: 2010
    ..In this proposal, we will perform translational studies and develop new tools in preparation of a clinical trial to treat and/or prevent TRALI. ..
  23. Marie Dominique Filippi; Fiscal Year: 2014
    ..level, we have identified a new pathway mediating Cdc42 functions and involving the leukocyte integrin CD11b/CD18. CD11b/CD18 is an adhesion molecule associated with a lethal human immunodeficiency disorder Leukocyte Adhesion ..
  24. Aging and novel therapeutic interventions in periodontal disease
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2010
    ..Our objective is to therapeutically exploit Del-1 to correct age-associated Del-1 deficiency and thereby prevent destructive periodontal inflammation. ..
  25. Effects of K+ Accumulation/Depletion in the Heart
    Guy Salama; Fiscal Year: 2013
    ..of [K+]a during arrhythmias elicited by ischemia/reperfusion applied either globally (zero flow) or locally via an LAD ligation...
  26. Jaehyung Cho; Fiscal Year: 2015
    ..A better understanding of how surface PDI regulates b2 integrin-mediated neutrophil recruitment into the site of inflammation may lead to the development of novel therapeutics to prevent and treat inflammation and tissue injury. ..
  27. SEQUENTIAL MODEL OF LEUKOCYTE ROLLING AND ARREST IN FLOW
    Michael Lawrence; Fiscal Year: 1999
    ..endothelium apparently proceeds by a sequential interaction of selectins with their ligands followed by binding of CD18 integrins to their endothelial cell ligands, ultimately leading to arrest and emigration of the rolling neutrophils...
  28. The role of Rap1 and its novel associated molecules in T cell responses
    Vassiliki A Boussiotis; Fiscal Year: 2011
    ..Our in vitro and in vivo studies will complement each other in understanding the effects of Rap1 at the molecular/signaling level and in the intact host. ..
  29. Antonio J Barbosa; Fiscal Year: 2014
    ..The leukocytic adhesion receptor integrin CD11b/CD18 (Mac- 1, [unreadable]M[unreadable]2) is central to the various biological functions of these cells...
  30. LFA-1 mediated Costimulation
    JIM F MILLER; Fiscal Year: 2010
    ..Ultimately, understanding the factors that determine the nature of T cell immune response are key to the development of potent and specific immune modulators. ..
  31. Adhesion Molecules in Allergic Lung Inflammation
    David Corry; Fiscal Year: 2009
    ..To prove this, we have begun to explore the role of CD18 (integrin a2) and CD11 a (integrin DL), the heterodimeric partner of T cell-expressed CD18 (forming leukocyte ..
  32. ERIK LEO RITMAN; Fiscal Year: 2014
    ..Then, repeat this procedure while the LAD coronary artery is infused with adenosine...
  33. Kenneth Walsh; Fiscal Year: 2016
    ..including ischemia-reperfusion injury, pressure overload and permanent left anterior descending coronary artery (LAD) ligation...
  34. Ravichandran Ramasamy; Fiscal Year: 2014
    ..I/R) in the isolated perfused heart or after occlusion/reperfusion of the left anterior descending (LAD) coronary artery...
  35. Genetic and Cellular Determinants of Arterial Thrombosis
    Roy L Silverstein; Fiscal Year: 2010
    ..Core F will provide a curriculum and career development support for physicians training in clinical thrombosis research in SCCOR laboratories. ..
  36. Jianyi Zhang; Fiscal Year: 2014
    ..resonance spectroscopy imaging 8 weeks after ligation of the distal left anterior descending coronary artery (LAD)...
  37. Migration of polyomavirus JC across the blood-brain-barrier
    Vivek Nerurkar; Fiscal Year: 2009
    ....
  38. JUSTIN RODNEY SAVAGE; Fiscal Year: 2015
    ....
  39. The Role of the Nuclear Lamina in Chromatin Organization and Gene Expression in N
    Marcos Estecio; Fiscal Year: 2012
    ..We developed and validated a method to study the chromatin binding to the nuclear lamina (LAD-Seq) that is independent from engineered plasmids transfection and applicable to primary, uncultured cells...
  40. Lina Lu; Fiscal Year: 2014
    ..that binding of FH on HSC inactivates C3 to generate fragment iC3b, a ligand of complement receptor (CR)3 (CD11b/CD18)...
  41. Development of transformed lactobacilli as a microbicide
    Richard B Markham; Fiscal Year: 2010
    ..Using this technology we will: 1) Raise antibodies in alpacas against the ectodomain of CD18, the beta-chain component of the CD11a/CD18 heterodimer that is LFA-1...
  42. EDWARD CARLOS SUAREZ; Fiscal Year: 2014
    ..protein (CRP), as well as attenuated stress-induced changes in in vitro cellular adhesion molecules (CD11/CD18) expression, stimulated production of proinflammatory cytokines by peripheral blood mononuclear cells and changes ..
  43. Stem cells and the fibroblast/adipocyte lineage in arrhythmogenic cardiomyopathy
    Karen L Vikstrom; Fiscal Year: 2010
    ..These animals will be utilized on additional experiments where acquired diseases (e.g., LAD occlusion;pacing-induced hypertrophy) are modeled, thus allowing identification of the origin of the resulting ..
  44. KAREN TARASZKA HASTINGS; Fiscal Year: 2015
    ..We will identify the factors that lad to increased Treg cells in the absence of GILT...
  45. John C Schimenti; Fiscal Year: 2016
    ..Errors in meiosis can lad to aneuploidy, chromosome aberrations, or gene mutations...
  46. Vineet Gupta; Fiscal Year: 2015
    ..The leukocytic 2 integrin CD11b/CD18 (a.k.a. Mac-1, aMb2) is central to various functions of these cells...
  47. Molecular mechanisms of C.albicans - leukocyte integrin interactions
    DMITRY ALEKSANDROVICH SOLOVIEV; Fiscal Year: 2012
    ..Previously, it has been demonstrated that the integrin 1M22 (CD11b/CD18) is the major neutrophil (PMN) receptor involved in C. albicans recognition...
  48. Skin Homing T Cells -- Molecular Characterization of CLA
    Thomas S Kupper; Fiscal Year: 2012
    ..Knowledge generated from this grant application over the next five years will have a significant impact on both areas. ..
  49. Elizabeth Scisci; Fiscal Year: 2015
    ..may not be sufficient for optimum uptake of PMNs by DCs;other co-receptors such as MR (CD206) and LFA-1 (CD11a/CD18) may be involved. Understanding the nature of these reactions between DCs and PMNs to P...
  50. Preserving Renal Function &Protective Immunity Via Anti-LFA1-Based CNI Avoidance
    Kenneth A Newell; Fiscal Year: 2013
    ..Our Collaborative will investigate efalizumab as an alternative to CNI-based immunosuppression in kidney and liver transplantation. ..
  51. Does HIV Enter Doomed Cells
    Sujatha Iyengar; Fiscal Year: 2011
    ....
  52. Alireza R Rezaie; Fiscal Year: 2015
    ..having altered anticoagulant and signaling properties in a mouse left anterior descending coronary artery (LAD) ischemia/reperfusion injury model;3) to investigate the mechanism by which ZPI interacts with its target proteases;..
  53. Lipoprotein Receptors and Inflammation in the Vessel Wall
    Dudley K Strickland; Fiscal Year: 2011
    ..abstract_text> ..
  54. Targeting B-cell lymphoma with Leukothera
    Benjamin A Belinka; Fiscal Year: 2013
    ..The data that we generate from the work described in this application is necessary to provide proof-of-principle and mechanistic knowledge for subsequent clinical testing in lymphoma patients. ..
  55. David W Crabb; Fiscal Year: 2016
    ..We will extend our knowledge of the basis for alcohol preference in rats by sequencing the genomes of P/NP and HAD/LAD rats and defining the sequences resulting from selective breeding...
  56. Yoji Shimizu; Fiscal Year: 2014
    ....
  57. Mechanisms of Immune Modulation Mediated by Yeast-derived Particulate Beta-Glucan
    Jun Yan; Fiscal Year: 2012
    ..of low molecular weight is capable of binding to the lectin site of complement receptor 3 (CR3, CD11b/CD18) and priming CR3+ effector cells for cytotoxicity of iC3b-opsonized tumor cells...
  58. Cytoskeletal regulation of T cell-APC interactions
    Anna Huttenlocher; Fiscal Year: 2012
    ..The proposed studies will lead to improved understanding of the mechanisms that regulate T cell-APC interactions and T cell activation and may provide the foundation for new strategies to treat autoimmune disease. ..
  59. EDWARD THOMAS LALLY; Fiscal Year: 2016
    ..The outcomes of toxin/membrane interactions will be assessed by biochemical, biophysical and morphological assays. ..
  60. CXCR4 regulation of tumor progression in Multiple Myeloma
    Irene M Ghobrial; Fiscal Year: 2012
    ..Targeting this process by mobilizing myeloma cells out of the marrow will lead to a higher sensitivity to killing of the cells with cytotoxic agents. ..
  61. Timothy A Springer; Fiscal Year: 2014
    ..We tackle this specific problem by developing integrin-targeted stabilized nanoparticles (I-tsNP): a novel nanoscale delivery vehicle to target therapeutic RNAs to blood cancers. ..
  62. Philadelphia Autoimmunity Center of Excellence
    A M Rostami; Fiscal Year: 2013
    ..The Clinical Component proposes novel clinical trial concepts and studies to understand the mechanisms of action of the therapeutics being tested. As such, they are an integral part of this ACE. ..
  63. Leukocyte Migration in Wounded Cornea
    Alan R Burns; Fiscal Year: 2011
    ..be assessed using antibody blockade and mice deficient in P- and E-selectin, leukocyte integrins (CD11a/GD18, CD11b/CD18, CD18), and members of the IgG superfamily (ICAM-1, PECAM-1 and JAM-C)...
  64. CELL SURFACE ANTIGENS ON HUMAN MACROPHAGES
    Robert Todd; Fiscal Year: 1999
    ..research during the previous funding period was to fain further insight about the genetic regulation of the CD11/CD18 family of beta2 integrins and to determine the functional relevance of these adhesion-promoting glycoproteins in ..