CD15

Summary

Gene Symbol: CD15
Description: fucosyltransferase 4
Alias: CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX, SSEA-1, alpha-(1,3)-fucosyltransferase 4, ELAM ligand fucosyltransferase, ELAM-1 ligand fucosyltransferase, Lewis X, alpha (1,3) fucosyltransferase, myeloid-specific, fucT-IV, fucosyltransferase IV, galactoside 3-L-fucosyltransferase, stage-specific embryonic antigen 1
Species: human

Top Publications

  1. doi CD138/syndecan-1 and SSEA-1 mark distinct populations of developing ciliary epithelium that are regulated differentially by Wnt signal
    Hideto Koso
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    Stem Cells 26:3162-71. 2008
  2. pmc MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma
    Pasqualino De Antonellis
    Centro di Ingegneria Genetica e Biotecnologia Avanzate, CEINGE, Naples, Italy
    PLoS ONE 6:e24584. 2011
  3. doi Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells
    Oriana Trubiani
    Department of Oral Science, University of Chieti Pescara, Chieti, Italy
    J Cell Physiol 225:123-31. 2010
  4. ncbi Monoclonal antibodies that recognize lacto-N-fucopentaose III (CD15) react with the adhesion-promoting glycoprotein family (LFA-1/HMac-1/gp 150,95) and CR1 on human neutrophils
    K M Skubitz
    J Immunol 139:1631-9. 1987
  5. ncbi Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line
    D A Withers
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 275:40588-93. 2000
  6. pmc CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors
    Cristina Patru
    Glial Plasticity lab, Inserm UMR 894, University Paris Descartes, Paris, France
    BMC Cancer 10:66. 2010
  7. ncbi Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation
    Xuesong Yang
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian 116027, PR China
    Int J Biochem Cell Biol 39:1722-30. 2007
  8. pmc Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    Tracy Ann Read
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:135-47. 2009
  9. doi Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways
    Xue Song Yang
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People s Republic of China
    J Cell Physiol 225:612-9. 2010
  10. doi TNF regulates sialyl-Lewisx and 6-sulfo-sialyl-Lewisx expression in human lung through up-regulation of ST3GAL4 transcript isoform BX
    Florent Colomb
    Universite Lille Nord de France, Lille 1, UGSF, CNRS, UMR 8576, 59650 Villeneuve d Ascq, France
    Biochimie 94:2045-53. 2012

Detail Information

Publications330 found, 100 shown here

  1. doi CD138/syndecan-1 and SSEA-1 mark distinct populations of developing ciliary epithelium that are regulated differentially by Wnt signal
    Hideto Koso
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    Stem Cells 26:3162-71. 2008
    ..Here, we identified CD138/syndecan-1 and stage specific embryonic antigen-1 (SSEA-1) CD15 as cell-surface antigens marking nonpigmented and pigmented CE, respectively...
  2. pmc MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma
    Pasqualino De Antonellis
    Centro di Ingegneria Genetica e Biotecnologia Avanzate, CEINGE, Naples, Italy
    PLoS ONE 6:e24584. 2011
    ..On the basis of this evidence, we hypothesized that miRNAs targeting the Notch pathway can regulate these phenomena, and can be used in anti-cancer therapies...
  3. doi Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells
    Oriana Trubiani
    Department of Oral Science, University of Chieti Pescara, Chieti, Italy
    J Cell Physiol 225:123-31. 2010
    ..Taken together, these data indicate the presence of immature MSCs in PDL and suggest that the frizzled-9/Wnt pathway plays an important role in regulating proliferation and differentiation of these cells...
  4. ncbi Monoclonal antibodies that recognize lacto-N-fucopentaose III (CD15) react with the adhesion-promoting glycoprotein family (LFA-1/HMac-1/gp 150,95) and CR1 on human neutrophils
    K M Skubitz
    J Immunol 139:1631-9. 1987
    ..The monoclonal antibodies that react with lacto-N-fucopentaose III (CD15) immunoprecipitated five distinct neutrophil surface proteins...
  5. ncbi Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line
    D A Withers
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 275:40588-93. 2000
    The alpha1,3-fucosyltransferase IV (FucTIV) encoded by its gene (FUTIV) is responsible for synthesis of Le(x) (Galbeta4[Fucalpha3]GlcNAcbeta3Galbeta1,R), which causes compaction in the morula stage of the preimplantation mouse embryo, as ..
  6. pmc CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors
    Cristina Patru
    Glial Plasticity lab, Inserm UMR 894, University Paris Descartes, Paris, France
    BMC Cancer 10:66. 2010
    ..Tumor initiating cells (TICs) provide a new paradigm for developing original therapeutic strategies...
  7. ncbi Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation
    Xuesong Yang
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian 116027, PR China
    Int J Biochem Cell Biol 39:1722-30. 2007
    b>Fucosyltransferase IV is an essential enzyme that catalyzes the synthesis of fucosylated oligosaccharides by transferring GDP-fucose to the terminal N-acetylglucosamine with the alpha1,3-linkage...
  8. pmc Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    Tracy Ann Read
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:135-47. 2009
    ..Patched mutant mouse, are propagated not by CD133(+) cells but by cells expressing the progenitor markers Math1 and CD15/SSEA-1...
  9. doi Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways
    Xue Song Yang
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, People s Republic of China
    J Cell Physiol 225:612-9. 2010
    ..b>Fucosyltransferase IV (FUT4) is an essential enzyme that catalyzes the synthesis of LeY oligosaccharide...
  10. doi TNF regulates sialyl-Lewisx and 6-sulfo-sialyl-Lewisx expression in human lung through up-regulation of ST3GAL4 transcript isoform BX
    Florent Colomb
    Universite Lille Nord de France, Lille 1, UGSF, CNRS, UMR 8576, 59650 Villeneuve d Ascq, France
    Biochimie 94:2045-53. 2012
    ..These results support further work aiming at the development of anti-inflammatory strategy to reduce chronic airway infection in diseases such as cystic fibrosis...
  11. ncbi [Detection of human cytomegalovirus-antigen in peripheral blood cells by using flow-cytometer]
    J Honda
    First Department of Internal Medicine, Kurume University
    Kansenshogaku Zasshi 70:923-30. 1996
    ..the phenotype of HCMV-infected mononuclear cells, the following phycoerythrin-conjugated mAb were used: CD8, CD15. These mAds were added to the whole blood and incubated...
  12. ncbi Lectin binding and uptake in human (myelo)monocytic cell lines: HL60 and U937
    U Schumacher
    University of Southampton, United Kingdom
    Ultrastruct Pathol 20:463-71. 1996
    ..two U937 subclones and HL60 were more pronounced, the latter expressing fucose residues, which might be part of the CD15 cell adhesion molecules...
  13. ncbi Osteomyelitis: diagnosis with (99m)Tc-labeled antigranulocyte antibodies compared with diagnosis with (111)In-labeled leukocytes--initial experience
    Christopher J Palestro
    Division of Nuclear Medicine, Long Island Jewish Medical Center, 270 05 76th Ave, New Hyde Park, NY 11040, USA
    Radiology 223:758-64. 2002
    ..99m-labeled murine immunoglobulin M monoclonal antigranulocyte antibody that binds to human polymorphonuclear leukocyte CD15 antigens with indium 111 ((111)In)-labeled leukocytes in the diagnosis of appendicular skeletal osteomyelitis.
  14. ncbi Developmental expression of the CD15-epitope in the brainstem and spinal cord of the mouse
    K W Ashwell
    School of Anatomy, University of NSW, Sydney, Australia
    Anat Embryol (Berl) 196:13-25. 1997
    The expression of the 3-fucosyl-N-acetyl-lactosamine (FAL, CD15, Le(x)) epitope has been examined immunohistochemically in paraffin sections of the brainstem of the mouse...
  15. ncbi Flow cytometry of peripheral blood and bone marrow cells from patients with hairy cell leukemia: phenotype of hairy cells, lymphocyte subsets and detection of minimal residual disease after treatment
    O Babusikova
    Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Neoplasma 48:350-7. 2001
    ..Other markers, not followed regularly, were occasionally expressed, such as CD34, CD38, CD71, CD15, CD10 and kappa/lambda light chains...
  16. ncbi Assessment of distribution of CD34 epitope classes in fresh and cryopreserved peripheral blood progenitor cells and acute myeloid leukemic blasts
    F Lanza
    Hematology Section, Dept of Biomedical Sciences and Advanced Therapies, University of Ferrara, St Anna Hospital, Corso Giovecca 203, 44100 Ferrara, Italy E mail
    Haematologica 84:969-77. 1999
    ..However, there are no data on the effects of cryopreservation on the expression of the three CD34 epitope classes, and on their relationship with the clonogenic capacity of PBPC collected by leukapheresis...
  17. ncbi The absence of apoeccrine glands in the human axilla has disease pathogenetic implications, including axillary hyperhidrosis
    D L Bovell
    School of Life Sciences, Glasgow Caledonian University, Glasgow, UK
    Br J Dermatol 156:1278-86. 2007
    ....
  18. ncbi Inflammatory infiltrate and interleukin-8 expression in the synovium of psoriatic arthritis--an immunohistochemical and mRNA analysis
    A Konig
    Orthopädische Universitätsklinik König Ludwig Haus, Wurzburg, Germany
    Rheumatol Int 17:159-68. 1997
    ..b>CD15+ neutrophil granulocytes were detected in four cases...
  19. ncbi Diagnostic and prognostic relevance of the immunophenotype in acute myelocytic leukemia
    V Callea
    Divisione di Ematologia, Ospedali Riuniti, Reggio Calabria, Italy
    Tumori 77:28-31. 1991
    ..Moreover, a constant negativity to HLA-DR and CD15 antigens in M3 and the contemporaneous expression of HLA-DR and CD11b antigens on the M4 and M5 leukemic cells were ..
  20. ncbi Differential expression of sialyl and non-sialyl-CD15 antigens on Hodgkin-Reed-Sternberg cells: significance in Hodgkin's disease
    D Benharroch
    Department of Pathology, Soroka University Medical Center, Beer Sheva, Israel
    Leuk Lymphoma 39:185-94. 2000
    b>CD15 expression has been used for years to confirm the diagnosis of Hodgkin's disease (HD)...
  21. ncbi Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury
    Melissa J Burne
    Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 169:2648-52. 2002
    ..Selectins bind to sialylated and fucosylated sLe(x) receptors, and two enzymes, fucosyltransferase IV (FucT-IV) and VII (FucT-VII), are important in the function of these receptors...
  22. pmc A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman's disease: successful response to rituximab and radiotherapy
    Lorenzo Falchi
    Section of Internal Medicine and Oncologic Sciences, Policlinico Monteluce, Perugia, Italy
    Eur J Haematol 79:455-61. 2007
    ..The CD30- and CD15-positive, Reed-Sternberg/Hodgkin cells, only occasionally expressed the CD20 molecule, but not leukocyte common ..
  23. pmc Immunomagnetic bead separation of mononuclear cells from contaminating granulocytes in cryopreserved blood samples
    Sergey N Preobrazhensky
    ARUP Laboratories, Institute for Clinical and Experimental Pathology, 500 Chipeta Way, Salt Lake City, UT 84108 1221, USA
    Cryobiology 59:366-8. 2009
    ..centrifugation fails to separate granulocytes from mononuclear cells and have explored using immunomagnetic anti-CD15 microbeads as an alternate method to separate these cell populations...
  24. ncbi Molecular analysis of lineage-specific chimerism and minimal residual disease by RT-PCR of p210(BCR-ABL) and p190(BCR-ABL) after allogeneic bone marrow transplantation for chronic myeloid leukemia: increasing mixed myeloid chimerism and p190(BCR-ABL) dete
    J Serrano
    Hematology Department of Reina Sofía Hospital, Cordoba, Spain
    Blood 95:2659-65. 2000
    ..polymerase chain reaction (VNTR [variable number of tandem repeats]-PCR) analysis in highly purified CD19+, CD3+, CD15+, and CD56+ cell fractions, whereas MRD was investigated in whole blood by reverse transcriptase-PCR (RT-PCR) of ..
  25. ncbi Vulvar hidradenitis suppurativa. Immunohistochemical evaluation of apocrine and eccrine involvement
    Debra S Heller
    Departments of Pathology and Laboratory Medicine and of Obstetrics, Gynecology and Women s Health, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Reprod Med 47:695-700. 2002
    ..To evaluate the pathology of vulvar hidradenitis suppurativa (HS)...
  26. ncbi Immune responses and their regulation by donor bone marrow cells in clinical organ transplantation
    James M Mathew
    Department of Surgery, Division of Transplantation R 440, University of Miami School of Medicine, 1600 N W 10th Ave, Miami, FL 33136, USA
    Transpl Immunol 11:307-21. 2003
    ..cells and the CD34(-) early progeny like CD38(+), CD2(+), CD5(+) and CD1(+) lymphoid cells as well as CD33(+) (but CD15(-)) myeloid cells down-regulated the MLR and CML responses of allogeneic PBMC stimulated with (autologous) donor ..
  27. ncbi [Analysis of immunophenotype and leukemia associated immunophenotype in 610 patients with acute myeloid leukemia]
    Yan Rong Liu
    Peking University, Institute of Hematology, People s Hospital, Beijing, China
    Zhonghua Xue Ye Xue Za Zhi 28:731-6. 2007
    ..To analyze the immunophenotype and leukemia associated immunophenotype (LAIP) of leukemia cells from patients with acute myeloid leukemia (AML) in minimal residual disease (MRD) detection...
  28. ncbi FUT4 and FUT9 genes are expressed early in human embryogenesis
    A Cailleau-Thomas
    U 504 INSERM, Universite de Paris Sud XI, 94807 Villejuif, France
    Glycobiology 10:789-802. 2000
    ..Finally, this FUT9 transcript has a single expressed exon as has been observed for most of the other vertebrate alpha2- and alpha3-fucosyltransferases...
  29. ncbi The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosa
    G Marchini
    Department of Woman and Child Health, Astrid Lindgren Children s Hospital, Karolinska Hospital C4 U1, Karolinska Institutet, S 171 76 Stockholm, Sweden
    Br J Dermatol 147:1127-34. 2002
    ..Erythema toxicum neonatorum is an inflammatory skin reaction of unknown aetiology and significance, commonly present in the healthy newborn infant...
  30. ncbi [Immunophenotypic features of acute myeloid leukemia with AML-1/ETO fusion gene]
    Jian Jun Zhang
    Flow Cytomertry Laboratory, Department of Laboratory Medical Examination, Guangdong Provincial People s Hospital, Guangzhou 510080, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:378-81. 2007
    ..001). In patients with M(2)/ETO(+) (AML-M(2)), the pattern of CD15/CD11b expression was seen as granulocytic differentiation with immature events showing CD15(+)CD11b(-) and more ..
  31. ncbi CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV
    F Nakayama
    Division of Cell Biology, Institute of Life Science, Soka University, Tokyo 192 8577, Japan
    J Biol Chem 276:16100-6. 2001
    The CD15 carbohydrate epitope is expressed in mature human neutrophils, monocytes, and promyelocytes. We aimed to determine the alpha1,3-fucosyltransferase responsible for the expression of CD15 in each subpopulation of leukocytes...
  32. ncbi SSEA-1 marks regionally restricted immature subpopulations of embryonic retinal progenitor cells that are regulated by the Wnt signaling pathway
    Hideto Koso
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Dev Biol 292:265-76. 2006
    ..Here, we identified SSEA-1 (CD15) as a novel surface antigen that can be used to define immature retinal progenitor cells...
  33. doi Expression and regulation of fucosyltransferase 4 in human endometrium
    Anna P Ponnampalam
    Monash University, Department of Obstetrics and Gynaecology, Monash Institute of Medical Research, Centre for Women s Health Research, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Reproduction 136:117-23. 2008
    ..Estrogen did not have any significant effects. These data suggest that the upregulation of selectin ligands in the human endometrium at the time of implantation may be mediated, at least in part, by the regulation of FUT4 expression...
  34. ncbi Developmental expression of the CD15 epitope in the hippocampus of the mouse
    K W Ashwell
    School of Anatomy, The University of NSW, 2052, NSW, Australia
    Cell Tissue Res 289:17-23. 1997
    The developmental expression of the 3-fucosyl-N-acetyl-lactosamine (CD15, Lex, SSEA-1) epitope has been examined immunohistochemically in paraffin sections of the mouse hippocampus...
  35. ncbi Nitric oxide induced by tumor cells activates tumor cell adhesion to endothelial cells and permeability of the endothelium in vitro
    K Yudoh
    Department of Orthopaedic Surgery, Toyama Medical and Pharmaceutical University, Japan
    Clin Exp Metastasis 15:557-67. 1997
    ..Human fibrosarcoma HT1080 cell surface phenotype analysis revealed the expression of "cluster of differentiation 15" (CD15) antigen and to a lesser extent, of "very late antigen-4" (VLA-4)...
  36. pmc Overexpression of alpha(1,3)-fucosyltransferase VII is sufficient for the acquisition of lung colonization phenotype in human lung adenocarcinoma HAL-24Luc cells
    M Martín-Satué
    Department Biologia Cellular, Institut de Recerca Oncologica, Barcelona, Spain
    Br J Cancer 80:1169-74. 1999
    ..This is the first report directly showing the contribution of an alpha(1,3)-Fuc-T to the metastatic behaviour of human lung adenocarcinoma cells...
  37. ncbi Myeloid differentiation and maturation of SCF+IL-3+IL-11 expanded AC133+/CD34+ cells selected from high-risk breast cancer patients
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, Czech Republic
    Neoplasma 47:73-80. 2000
    ..Enriched AC133+ cells coexpressed 80% CD34+, 6.6% CD33+ and 2% CD15+. Separated AC133+ cells contained 600 GFU-GM/10(4) cells and 70 BFU-E/10(4) cells...
  38. pmc Lewis x antigen mediates adhesion of human breast carcinoma cells to activated endothelium. Possible involvement of the endothelial scavenger receptor C-type lectin
    Maria Teresa Elola
    Fundacion Instituto Leloir, Patricias Argentinas 435 1405, Buenos Aires, Argentina
    Breast Cancer Res Treat 101:161-74. 2007
    b>Lewis x (Le(x), CD15), also known as SSEA-1 (stage specific embryonic antigen-1), is a trisaccharide with the structure Galbeta(1-4)Fucalpha(1-3)GlcNAc, which is expressed on glycoconjugates in human polymorphonuclear granulocytes and ..
  39. ncbi Mice lacking alpha1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors
    Takashi Kudo
    Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology AIST, Central 2, Open Space Laboratory, 1 1 1 Umezono, Tsukuba, Ibaraki 305 8568, Japan
    Glycobiology 17:1-9. 2007
    The 3-fucosyl-N-acetyllactosamine [Lewis x (Le(x)), CD15, SSEA-1] carbohydrate structure is expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system and has been implicated in cell-cell recognition, ..
  40. ncbi [Epithelioid angiomyolipoma of kidney: clinicopathologic study of two cases and review of literature]
    Yu hong Meng
    Department of Pathology, Navy General Hospital of PLA, Beijing 100037, China
    Zhonghua Bing Li Xue Za Zhi 36:19-23. 2007
    ..To study the histopathologic features, differential diagnosis and prognosis of epithelioid angiomyolipoma (EAML) of kidney...
  41. doi B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology
    Antonino Carbone
    Department of Pathology and Laboratory Medicine, Istituto Nazionale Tumori, 20133 Milano, Italy
    Hum Pathol 41:621-31. 2010
    ..but contain tumor cells resembling Reed-Sternberg cells and displaying an aberrant phenotype such as CD20(-), CD15(-/+) CD45(+), CD30(+), Pax5(+), OCT2(+/-), and BOB1(+/-)...
  42. pmc Knockdown of fucosyltransferase III disrupts the adhesion of circulating cancer cells to E-selectin without affecting hematopoietic cell adhesion
    Xiaoyan Yin
    Department of Biomedical Engineering, Cornell University, 205 Weill Hall, Ithaca, NY 14853, USA
    Carbohydr Res 345:2334-42. 2010
    ..Combined with the novel siRNA delivery platform recently developed in our laboratory, FUT3 siRNA could be a promising conjunctive therapy aiming at reducing the metastatic virulence of circulating epithelial cancer cells...
  43. ncbi Localization of the CD15-epitope in the inner ear of the developing mouse
    A M Meyer zym Gottesberge
    Research Laboratory of Dept of Otorhinolaryngology, Heinrich Heine University of Dusseldorf, Moorenstrasse 5, D 40255 Düsseldorf, Germany
    Cell Tissue Res 283:395-401. 1996
    The expression of the 3-fucosyl-N-acetyl-lactosamine (CD15) epitope during the embryonic development of the mouse inner ear has been immunohistochemically studied on paraffin sections from day 8.5 to day 19 of gestation...
  44. ncbi Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma with a CD15(+)CD30(-) phenotype
    Naho Yoshizawa
    Department of Dermatology, Shizuoka Municipal Shimizu Hospital, 1231 Miyakami Shimizu, Shizuoka 424 8636, Japan
    Eur J Dermatol 17:441-2. 2007
    ..While the CD15 antigen is typically associated with classic Hodgkin's lymphoma, aggressive peripheral T-cell lymphomas, including ..
  45. ncbi Microcystic adnexal carcinoma: an immunohistochemical reappraisal
    Mai P Hoang
    Department of Pathology, UMass Medical School, Worcester, MA, USA
    Mod Pathol 21:178-85. 2008
    ..study, we compare the expression of cytokeratin (CK) 15, CK7, CK20, CK903, carcinoembryonic antigen (CEA), CD10, CD15 and BerEP4 in 13 microcystic adnexal carcinoma, eight desmoplastic trichoepithelioma, 10 infiltrative basal cell ..
  46. ncbi TIA-1+ cytotoxic large T-cell lymphoma of the mediastinum: case report
    Grace C H Yang
    Department of Pathology, Medical Center, New York University School of Medicine, New York, NY 10016, USA
    Diagn Cytopathol 26:154-7. 2002
    ..cells are LCA positive, expressing cytoplasmic CD3 diffusely and TIA-1 focally, but negative for EMA, CD4, CD8, CD15, CD20, CD30, and CD56...
  47. ncbi Cellular and molecular studies on infant null acute lymphoblastic leukemia
    F Katz
    Imperial Cancer Research Fund, London, England
    Blood 71:1438-47. 1988
    ..Two patients also expressed the myeloid-associated markers CD33 (MY9) and CD15 (TG1), and coexpression of CD19 and CD33 was confirmed in these two by using dual marker flow cytometry (..
  48. ncbi Prion protein expression in human leukocyte differentiation
    V C Dodelet
    Department of Microbiology and Immunology, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    Blood 91:1556-61. 1998
    ..of PrPC during human leukocyte maturation by flow cytometry with monoclonal antibodies to PrPC, the glycan moiety CD15, and the stem cell marker CD34. We observe that prion protein is present on CD34+ bone marrow (BM) stem cells...
  49. ncbi Embigin/basigin subgroup of the immunoglobulin superfamily: different modes of expression during mouse embryogenesis and correlated expression with carbohydrate antigenic markers
    Q W Fan
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Dev Growth Differ 40:277-86. 1998
    ..embigin with Dolichos biflorus agglutinin binding sites and basigin with LeX antigen and more closely with fucosyltransferase IV, which forms the antigenic epitope...
  50. ncbi [WHO classification of Hodgkin's lymphoma and its molecular pathological relevance]
    M L Hansmann
    Senckenbergisches Institut für Pathologie, Universitätsklinik Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main
    Pathologe 23:207-18. 2002
    ..by definition only by the immunohistochemical characteristics of the Hodgkin and Reed/Sternberg cells (HRS) (CD30+, CD15+, CD20-)...
  51. ncbi CD30-positive T-cell lymphomas co-expressing CD15: an immunohistochemical analysis
    Wojciech Gorczyca
    IMPATH Inc, New York, NY 10019, USA
    Int J Oncol 22:319-24. 2003
    ..The latter differs by expression of CD15 and lack of CD45, pan-T antigens and ALK expression...
  52. ncbi Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum
    Jason A Carlyon
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    Blood 102:3387-95. 2003
    ..However, murine infection does not require neutrophil PSGL-1 expression, which has important implications for understanding how A phagocytophilum binds and infects neutrophils...
  53. ncbi [Hodgkin disease of the nasopharynx: report of three cases]
    L Kochbati
    Service de radiothérapie carcinologique, Institut Salah Azaiz, Boulevard 9 avril, Bab Saadoun, 1006 Tunis, Tunisie
    Cancer Radiother 10:142-4. 2006
    ..Histological study showed mixed cellularity type of HD in all cases. The Reed Sternberg cells expressed both of CD15 and CD30 in one case, and only one of them in the other cases...
  54. ncbi Thyroid follicular carcinoma-like tumor of kidney: a case report with morphologic, immunohistochemical, and genetic analysis
    Soo Jin Jung
    Department of Pathology, Inje University College of Medicine, Busan, Korea
    Am J Surg Pathol 30:411-5. 2006
    ..completely negative for CK7, CK19, CK20, CK34betaE12, carcinoembryonic antigen, epithelial membrane antigen, and CD15. Chromosomal gains of 7q36, 8q24, 12, 16, 17p11-q11, 17q24, 19q, 20q13, 21q22...
  55. ncbi Follicular dendritic cell tumor as an unknown primary tumor
    Yoshihiro Yakushijin
    Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Tohon shi, Ehime 791 0295, Japan
    Int J Clin Oncol 12:56-8. 2007
    ..CD45), myeloperoxidase (MPO), terminal deoxynucleotidyl transferase (TdT), lysozyme, CD1a, CD3, CD4, CD10, CD15, CD20 (L26), CD21, CD23, CD34, CD43, CD56, CD68, CD79a, CD138, and EBER-1 in situ...
  56. doi An optimized method to separate reticulocytes from peripheral blood for molecular analysis
    R Petruzzelli
    Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Naples, Italy
    Int J Lab Hematol 31:359-63. 2009
    ..After erythrocyte lysis, CD15(+)and CD45(+) peripheral cells were negatively sorted to remove leucocyte populations that could have affected the ..
  57. doi Up-regulation of autophagy in small intestine Paneth cells in response to total-body gamma-irradiation
    Nikolai V Gorbunov
    Armed Forces Radiobiology Research Institute, Bethesda, MD 20889 5603, USA
    J Pathol 219:242-52. 2009
    ..This effect predominantly occurred in the CD15-positive Paneth cells and was associated with accumulation of LC3-II isoform...
  58. doi Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis
    Ken Satoh
    Satoh Medical Clinic, Sakata, Japan
    Am J Med Sci 338:334-5. 2009
    ..Immunohistological studies showed that these cells were positive for CD30 and CD79a, but not for CD15 or CD20. In situ hybridization identified Epstein-Barr virus latency-associated RNA expression in these cells...
  59. doi BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin's lymphoma from primary mediastinal large B-cell lymphoma
    Sylvia Hoeller
    Department of Pathology, University of Basel, Basel, Switzerland
    Histopathology 56:217-28. 2010
    ....
  60. doi Complex display of putative tumor stem cell markers in the NCI60 tumor cell line panel
    Christina H Stuelten
    Cell and Cancer Biology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    Stem Cells 28:649-60. 2010
    ..We investigated expression of putative CIC surface markers (CD15, CD24, CD44, CD133, CD166, CD326, PgP) and the activity of aldehyde dehydrogenase in the NCI60 panel singly and in ..
  61. doi The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach
    Marco Trinchera
    Department of Biomedical Sciences Experimental and Clinical DSBSC, University of Insubria, Via JH Dunant 5, 21100 Varese, Italy
    Int J Biochem Cell Biol 43:130-9. 2011
    Sialyl Lewis x (sLex) is a selectin ligand whose overexpression in epithelial cancers mediates metastasis formation. The molecular basis of sLex biosynthesis in colon cancer tissues is still unclear...
  62. ncbi Clinical implications of immunophenotypic abnormalities of bone marrow myeloid cell compartment in myelodysplastic syndromes
    D Marisavljevic
    Medical Center Bezanijska kosa, Department of Hematology, Belgrade, Serbia
    J BUON 15:746-52. 2010
    ..to evaluate the biological and clinical implications of immunophenotypic abnormalities of bone marrow myeloid cell compartment in patients with primary myelodysplastic syndromes (MDS)...
  63. pmc Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients
    Bethany L Mundy-Bosse
    Department of Integrated Biomedical Sciences, The Ohio State University, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Columbus, OH 43210, USA
    Cell Immunol 270:80-7. 2011
    ..Flow cytometric analysis for CD33+/HLA-DR-neg/CD15+/CD11b+ MDSC revealed increased MDSC in patients with lower IES scores (P = 0.009)...
  64. pmc Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms
    Hilda Rachel Diamond
    Laboratory of Immunology, Bone Marrow Transplantation Unit, National Cancer Institute, Praça Cruz Vermelha n 23, 6 andar Centro, Rio de Janeiro, RJ, 20230 130, Brazil
    J Hematol Oncol 4:39. 2011
    ..CD117⁺, CD13(-/+), HLA Dr(high), CD123(high), and CD203c⁺ blast cells lacking expression of CD7, CD10, CD34, CD15, CD14, CD56, CD36, CD64, and cytoplasmic tryptase...
  65. doi Flow cytometry in myelodysplastic syndrome: analysis of diagnostic utility using maturation pattern-based and quantitative approaches
    Anita Chopra
    Department of Laboratory Oncology, IRCH, All India Institute of Medical Sciences, DII 44, AIIMS Campus, Ansari Nagar, New Delhi, 110029, India
    Ann Hematol 91:1351-62. 2012
    ..parameters that characterized MDS included FCM score of >3, percentage CD34(+) B cells, and expression of CD11b, CD15, and CD56 on myeloblasts...
  66. doi Large cell transformation of mycosis fungoides on fine needle aspiration: an unusual case mimicking classical Hodgkin lymphoma
    A P Subhawong
    Department of Pathology, The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Acta Cytol 56:321-4. 2012
    ..The cells were also positive for CD15 and CD4...
  67. doi A case of primary signet-ring cell/histiocytoid carcinoma of the eyelid: immunohistochemical comparison with the normal sweat gland and review of the literature
    Mai Iwaya
    Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Nagano, Japan
    Am J Dermatopathol 34:e139-45. 2012
    ..that was similar to that of the Moll gland: MUC6(+), GlcNAcα1→4Gal→R(-), MUC2(-), MUC5AC(-), GCDFP15(+), CD15(+), S100(-), CK7(+), CK20(-), ER(+), PgR (+), HER2(-), E-cadherin(+), p63(-), PSA(-), and TTF-1(-)...
  68. doi [Clinical analysis of acute myeloid leukemia with CBFB-MYH11-positive]
    Ting Ting Cao
    Department of Hematology, General Hospital of Chinese PLA, Beijing, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 21:305-10. 2013
    ..Patients with this fusion gene are often associated with high frequency of CD33, CD34, CD117, HLA-DR, CD15, CD64 and CD14 expression. Patients with CBFB-MYH11 have a tendency of higher CR rate, longer RFS and OS.
  69. doi Standard therapies versus novel therapies in Hodgkin lymphoma
    A Gallamini
    Hematology Department, Lacassagne Cancer Center, Nice University, Nice, France Electronic address
    Immunol Lett 155:56-9. 2013
    ..as monocyte-derived MDSC (Mo-MDSC) with a phenotype CD14+/dull and granulocyte-derived MDSC (G-MDSC) expressing CD15 on cell surface. The latter were shown to produce arginase...
  70. doi [Immunophenotypic characteristics of peripheral blood cells in normal elderly men]
    Ya Zhe Wang
    Institute of Hematology, People s Hospital, Peking University, Beijing 100044, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 21:1585-90. 2013
    ..015%-0.020%), with high expression of HLA-DR, CD33, CD13 and CD117, low expression of myeloid antigens, such as CD15, CD11b and CD16, while lymphoid antigens were seldom positive, including CD7, CD19 and CD56...
  71. doi Retinoic acid induces mouse bone marrow-derived CD15⁺, Oct4⁺ and CXCR4⁺ stem cells into male germ-like cells in a two-dimensional cell culture system
    Iraj Ragerdi Kashani
    Department of Anatomical Sciences, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Cell Biol Int 38:782-9. 2014
    We have examined the effect of retinoic acid (RA) on differentiation of bone marrow-derived CD15(+) , Oct4(+) and CXCR4(+) cells into male germ cells...
  72. doi [Primary pulmonary Hodgkin lymphoma diagnosed by CT-guided percutaneous biopsy]
    Naoki Watanabe
    Department of Hematology, Juntendo University School of Medicine
    Rinsho Ketsueki 56:41-3. 2015
    ..PPHL is very rare, it should be included in the differential diagnosis of lung tumors and immunological staining with CD15 and CD30 is recommended. Furthermore, carefully planned CT-guided lung biopsy is useful for diagnosing PPHL.
  73. doi Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway
    Yu Mei Zhang
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian, People s Republic of China
    FEBS Lett 589:1225-33. 2015
    Glycosylation plays a significant role in determining the receptivity of the uterine endometrium to embryo. Fucosyltransferase IV (FUT4) is expressed stage-specifically in the uterine endometrium of mammalians, and considered as a marker ..
  74. doi Preservation of KIT genotype in a novel pair of patient-derived orthotopic xenograft mouse models of metastatic pediatric CNS germinoma
    Holly Lindsay
    Department of Pediatrics, Baylor College of Medicine Texas Children s Cancer Center, 1102 Bates, Suite 1030 07, Houston, TX, 77030, USA
    J Neurooncol 128:47-56. 2016
    ..Expression of putative cancer stem cell markers (CD133, CD15, CD24, CD44, CD49f) was analyzed through flow cytometry...
  75. doi Effects of biocide treatments on the biofilm community in Domitilla's catacombs in Rome
    Clara Urzì
    Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F Stagno d Alcontres 31, 98166 Messina, Italy Electronic address
    Sci Total Environ 572:252-262. 2016
    ..the changes occurring to the microbial community present in the biofilm in one site of the Catacombs of Domitilla (CD15) before and after a biocide treatment (a mixture of quaternary ammonium compounds and octylisothiazolone, OIT), ..
  76. doi Circulating Breast Carcinoma Cells Mimicking Therapy-Related Acute Myeloid Leukemia
    Daniel J Rowan
    1 Medical College of Wisconsin, Milwaukee WI, USA
    Int J Surg Pathol 25:87-93. 2017
    ..Flow cytometry showed a 9% population of CD45 dim positive, CD13 partial positive, and CD15 variably positive cells...
  77. doi Reversible infliximab-related lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis
    Atsushi Komatsuda
    Third Department of Internal Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan
    Mod Rheumatol 18:315-8. 2008
    ..Immunohistological studies showed that these cells were positive for CD15, CD30, and Epstein-Barr virus (EBV) latent membrane protein...
  78. doi Granulocytic differentiation of HL-60 promyelocytic leukemia cells is associated with increased expression of Cul5
    Shaneen S Baxter
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    In Vitro Cell Dev Biol Anim 45:264-74. 2009
    ..by examining superoxide anion production, nuclear morphology, and changes in the expression of CD11b, CD13, and CD15. Quantitative real-time RT-PCR was used to measure Cul5 mRNA expression and also the expression of other components ..
  79. doi Synchronous meningioma and anaplastic large cell lymphoma
    Chaim B Colen
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, Michigan 48225, USA
    Neuropathology 30:260-6. 2010
    ..strongly immunoreactive for CD3 and CD30 but remained unstained with EMA, anaplastic lymphoma kinase-1 (ALK-1), CD15 or cytotoxic associated antigen TIA-1. Smaller mature lymphocytes, chiefly T-cells, were intermixed...
  80. doi Isolation and in vitro characterisation of dental pulp stem cells from natal teeth
    Erdal Karaoz
    Stem Cell and Gene Therapy Research and Applied Center, Kocaeli University, Kocaeli, Turkey
    Histochem Cell Biol 133:95-112. 2010
    ..hNDP-SCs and hBM-MSCs expressed CD13, CD44, CD90, CD146 and CD166, but not CD3, CD8, CD11b, CD14, CD15, CD19, CD33, CD34, CD45, CD117, and HLA-DR...
  81. pmc Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia
    Jeffrey J Pu
    Division of Hematology, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Eur J Haematol 87:37-45. 2011
    ..To investigate the natural history of paroxysmal nocturnal hemoglobinuria (PNH) clones in patients with acquired aplastic anemia (AA)...
  82. pmc Circulating and tumor-infiltrating myeloid-derived suppressor cells in patients with colorectal carcinoma
    Bin Zhang
    Department of Colo Rectal Disease Surgery, The Second Artillery General Hospital, Beijing, China
    PLoS ONE 8:e57114. 2013
    ..MDSCs shows that they express high CD13 and CD39, low CD115, CD117, CD124 and PD-L1, and devoid of CD14, CD15 and CD66b, reminiscent of precursor myeloid cells...
  83. pmc Molecular Analysis of Neutrophil Differentiation from Human Induced Pluripotent Stem Cells Delineates the Kinetics of Key Regulators of Hematopoiesis
    Colin L Sweeney
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
    Stem Cells 34:1513-26. 2016
    ..By late Stage-4, increased CD15, CD16b, and C/EBPɛ expression were observed, with 25%-65% of cells exhibiting morphology and functions of mature ..
  84. ncbi Expression of FLT3 and VEGFR1 on myeloid derived suppressor cells (MDSC) in renal cell carcinoma (RCC) patients (Pts)
    S George
    Cleveland Clinic Taussig Cancer Institute, Cleveland, OH The Cleveland Clinic Lerner Research Institute, Cleveland, OH
    J Clin Oncol 26:5108. 2008
    5108 Background: MDSC are immature myeloid cells (CD15+ CD14- CD33+ HLADR- and CD11b+) that are over expressed and are immunosuppressive in cancer pts including RCC...
  85. ncbi CD15(+) acute lymphoblastic leukemia and subsequent monoblastic leukemia: persistence of t(4;11) abnormality and B-cell gene rearrangement
    C H Dunphy
    Division of Hematopathology, Department of Pathology, St Louis University Health Sciences Center, St Louis University School of Medicine, St Louis, MO, USA
    Arch Pathol Lab Med 125:1227-30. 2001
    ..in the translocation of chromosomes 4 and 11 (t[4;11]) has been characteristically associated with calla-negative CD15(+) acute lymphoblastic leukemia (ALL) of early pre-B-cell origin...
  86. ncbi HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor
    Tom Taghon
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent University Hospital, Ghent, Belgium
    Blood 99:1197-204. 2002
    ..However, there was a slight reduction in the number of CD15(+) granulocytic cells, which were blocked in their final maturation...
  87. ncbi Low-grade renal cell carcinoma arising from the lower nephron: a case report with immunohistochemical, histochemical and ultrastructural studies
    M Otani
    Department of Pathology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Pathol Int 51:954-60. 2001
    ..Immunohistochemically, tumor cells were positive for high molecular weight cytokeratins, vinculin, vimentin, CD15 and epithelial membrane antigen, and showed affinities with some kinds of lectins...
  88. ncbi Abnormal expression of CD antigens in mastocytosis
    Luis Escribano
    Servicio de Hematologia, Mast Cell Unit, Hospital Ramon y Cajal, Madrid, Spain
    Int Arch Allergy Immunol 127:127-32. 2002
    ..characterized by the expression of CD117, CD33 and Fc epsilon RI in the absence of reactivity for CD14, CD15 and lymphoid-lineage-associated antigens...
  89. ncbi [Minimal residual disease in acute myeloid leukemia in children--standardization and evaluation of immunophenotyping in the AML-BFM-98 study]
    D Reinhardt
    Pädiatrische Hämatologie Onkologie, Universitat Munster, Germany
    Klin Padiatr 214:179-87. 2002
    ..However, the impact on treatment stratification is not established. The AML-BFM 98 MRD study started in 1/2000 in order to evaluate, standardize and establish immunophenotyping in AML in children...
  90. ncbi Hemophagocytic syndrome as the primary clinical symptom of Hodgkin's disease
    H Kojima
    Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Ann Hematol 82:53-6. 2003
    ..Reevaluation of the bone marrow specimen revealed the infiltration of small numbers of CD30-, CD15-, and EBER-1-positive large-sized lymphocytes with bizarre nucleus...
  91. ncbi Gastric myeloid metaplasia: a case report and review of the literature
    Denis Chatelain
    Department of Pathology, Centre Hospitalo Universitaire Amiens, Amiens, France
    Arch Pathol Lab Med 128:568-70. 2004
    ..The granulocytes were positive for CD15, CD68, and myeloperoxidase on immunohistochemistry, and the megakaryocytes showed positive reactivity for factor ..
  92. ncbi Impact of thyroid hormone deficiency on the developing CNS: cerebellar glial and neuronal protein expression in rat neonates exposed to antithyroid drug propylthiouracil
    Gui hua Li
    Department of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cerebellum 3:100-6. 2004
    ..cerebellar proteins that are known to be directly [protein expressing 3-fucosyl-N-acetyl-lactosamine antigen (CD15), neuronal cell adhesion molecule (L1)] or indirectly [glial fibrillary acidic protein (GFAP)], involved in glial-..
  93. ncbi Simultaneous maintenance of human cord blood SCID-repopulating cells and expansion of committed progenitors at low O2 concentration (3%)
    Zoran Ivanovic
    Laboratory for Studies on Hematopoiesis Molecular and Functional Aspects, Bordeaux 2 University, France
    Stem Cells 22:716-24. 2004
    ..Their phenotypic profile (antigens: HLA-DR, CD117, CD33, CD13, CD11b, CD14, CD15, and CD38) was not modified, with exception of CD133, whose expression was lower at 3% O2...
  94. ncbi Immunohistochemical differentiation of extra-ocular sebaceous carcinoma from other skin cancers
    Shin Ichi Ansai
    Department of Sensory Medicine, Division of Dermatology and Plastic Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    J Dermatol 31:998-1008. 2004
    ..3 antibody (CA15.3), anti-CD15 antibody (CD15), anti-breast carcinoma associated antigen antibody (B6...
  95. pmc Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens
    Tomas Kalina
    Department of Immunology, Charles University 2nd Medical School, Prague, Czech Republic
    BMC Cancer 5:38. 2005
    ....
  96. pmc Mechanisms of abruption-induced premature rupture of the fetal membranes: thrombin-enhanced interleukin-8 expression in term decidua
    Charles J Lockwood
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, PO Box 208063, Room 334FMB, New Haven, CT 06520 8063, USA
    Am J Pathol 167:1443-9. 2005
    ..Accordingly, immunostaining for the neutrophil marker CD15 was performed in placentas obtained after overt abruption (decidual hemorrhage) with or without PPROM and in ..
  97. ncbi T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction
    Hyeon Seok Eom
    Transplantation Biology Research Center, Bone Marrow Transplantation Section, Massachusetts General Hospital Harvard Medical School, Boston, 02129, USA
    Exp Hematol 33:1564-73. 2005
    ..We hypothesized that Fuc-TIV(-/-)/Fuc-TVII(-/-) donor T cells might have reduced capacity to roll on vessels of inflamed target tissues and mediate graft-vs-host disease (GVHD)...
  98. ncbi Immunochemical, ultrastructural and electrophysiological investigations of bone-derived stem cells in the course of neuronal differentiation
    Sabine Wenisch
    Experimental Trauma Surgery, Justus Liebig University, Kerkrader Strasse 9, 35394 Giessen, Germany
    Bone 38:911-21. 2006
    ..neuron-specific enolase, beta-III-tubulin, neurofilament-H and HNK-1, while only a subpopulation expressed CD15 and synaptophysin...
  99. ncbi Dynamic control of oligosaccharide modification in the mammary gland: linking recombinant human erythropoietin functional analysis of transgenic mouse milk-derived hEPO
    Deug Nam Kwon
    Department of Dairy Science, Division of Applied Life Science, College of Agriculture and Life Science, Gyeongsang National University, 660 701, Chinju, Gyeongnam, Korea
    Transgenic Res 15:37-55. 2006
    ..In light of these findings, we suggest that the mammary glands of transgenic animals provide a sufficient environment to generate rhEPO with post-translational modifications for biopharmaceutical use...
  100. ncbi Proliferative index and CD15 expression in pediatric classical Hodgkin lymphoma
    Veronique Dinand
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India
    Pediatr Blood Cancer 50:280-3. 2008
    This study was conducted to assess the clinical and prognostic significance of lack of CD15 expression, proliferative index (PI), and expression of tumor suppressor protein p53 in pediatric classical Hodgkin lymphoma (CHL).

Research Grants14

  1. P-21 INDUCTION IN MYELOID DIFFERENTIATION
    Richard Steinman; Fiscal Year: 1999
    ..and define the relationship of p21 expression to cell cycle stage and to the presence of CD11b, CD14, and CD15 antigen expression...
  2. Analysis of Alveolar Type II cells in Normal and Fibrotic Human Lung
    Paul J Wolters; Fiscal Year: 2012
    ..2) To isolate and characterize an alveolar Type II cell subtype expressing CD15 found in IPF lungs...
  3. OLIGOSACCHARIDES AS ANTI INFLAMMATORY AGENTS
    Peter Ward; Fiscal Year: 1999
    ..categories of oligosaccharide-based selectin antagonists will be prepared and studied; (i) multivalent sialyl Lewis x- bearing N-linked oligosaccharides (Project V), (ii) chemically synthesized selectin ligand analogues composed of ..
  4. Development Therapy for Metastatic Colorectal Cancer
    Janet Houghton; Fiscal Year: 2007
    ..time to disease progression, response, and how changes in Fas expression correlate with elevated expression in CD15+ and CD56+ cells, as well as toxicity and IFN-gamma pharmacokinetics, will be determined...
  5. Experimental Uveal Melanoma and Ocular Immune Privilege
    KYLE MCKENNA; Fiscal Year: 2007
    ..abstract_text> ..
  6. EXPERIMENTAL THERAPY OF COLON CANCER WITH ANTISENSE FUTS
    Brent Weston; Fiscal Year: 2004
    ..cells along vascular endothelium is mediated through selectin adhesion receptors and their ligands, sialyl Lewis x (sLex) and sialyl Lewis a (sLea)...
  7. Endocytosis in cardiac myocytes
    Ion Jovin; Fiscal Year: 2005
    ..The discoverry of polypeptides that guide macromolecules to specific cellular organelles or compartments can have profound implications for understanding microbial invasion and for refining gene therapy. ..
  8. Molecular Studies of Severe Congenital Neutropenia
    Andrew Aprikyan; Fiscal Year: 2005
    ..These models will be useful for development of novel therapeutic strategies for treatment of severe congenital neutropenia and prevention of its evolution to acute myeloid leukemia. ..
  9. Examination of FLT3 Mutations in Acute Myeloid Leukemia
    Derek Stirewalt; Fiscal Year: 2006
    ..Together, the research proposal and educational program provide Dc Stirewalt with the skills to become an independent clinical investigator. ..
  10. GENETIC EPIDEMIOLOGY OF RESPONSES TO ANTIHYPERTENSIVES
    Stephen Turner; Fiscal Year: 2006
    ....
  11. Anthipertensive PharmacoGenomics
    Stephen Turner; Fiscal Year: 2006
    ..abstract_text> ..
  12. Genetics of Chronic Kidney Disease
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  13. Genetics of Microangiopathic Brain Injury
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  14. Decidual-Endothelial Tissue Factor and IUGR
    Charles Lockwood; Fiscal Year: 2006
    ..Additionally, we will correlate maternal plasma levels of two sensitive thrombin markers with the presence of acquired or inherited thrombophilias in the selected patient population. ..