CD14

Summary

Gene Symbol: CD14
Description: CD14 molecule
Alias: monocyte differentiation antigen CD14, myeloid cell-specific leucine-rich glycoprotein
Species: human

Top Publications

  1. pmc Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity
    Hans Rempel
    Department of Laboratory Medicine at the Veterans Affairs Medical Center, San Francisco, California, United States of America
    PLoS ONE 3:e1967. 2008
  2. ncbi CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex
    Takashi Nakata
    Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Nishi 7, Kita 13, Kita ku, Sapporo 060 8586, Japan
    Cell Microbiol 8:1899-909. 2006
  3. pmc Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis
    Zhengting Wang
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    PLoS ONE 7:e45144. 2012
  4. doi Serum sCD14, polymorphism of CD14(-260) and periodontal infection
    T Raunio
    Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu 90014, Finland
    Oral Dis 15:484-9. 2009
  5. doi Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE
    M A Tewfik
    Department of Otolaryngology Head and Neck Surgery, Montreal General Hospital, McGill University, Montreal, Canada
    Allergy 64:746-53. 2009
  6. ncbi A promoter polymorphism in the CD14 gene is associated with elevated levels of soluble CD14 but not with IgE or atopic diseases
    M Kabesch
    University Children s Hospital, Ludwig Maximilian s University Munich, Munchen, Germany
    Allergy 59:520-5. 2004
  7. ncbi Monocyte antigen CD14 is a phospholipid anchored membrane protein
    D L Simmons
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Blood 73:284-9. 1989
  8. pmc Polymorphisms within inflammatory genes and colorectal cancer
    Stefano Landi
    Genetics Department of Biology, University of Pisa, Via S, Giuseppe 22, 56126, Pisa, Italy
    J Negat Results Biomed 5:15. 2006
  9. ncbi Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kappa B, ERK 1/2 and p38 MAPK in host monocytes
    Mingqun Lin
    Department of Veterinary Biosciences, 1925 Coffey Road, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 6:175-86. 2004
  10. doi Genetic variants in immunoregulatory genes and risk for childhood lymphomas
    Elisabeth Andrie
    Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, 75 Mikras Asias Str, Goudi, Athens, Greece
    Eur J Haematol 83:334-42. 2009

Research Grants

  1. Role of CD14 and other innate immune receptors in severe sepsis
    Sanna M Goyert; Fiscal Year: 2012
  2. ROLE OF THE CD14 LPS RECEPTOR IN CORNEAL INFLAMMATION
    JOHN ANSEL; Fiscal Year: 2004
  3. CHARACTERIZATION OF THE LPS RECEPTOR FOR ACUTE PHASE
    Sanna Goyert; Fiscal Year: 2002
  4. Vasoprotective Actions of Autologous Cell Transfer
    Robert Simari; Fiscal Year: 2007
  5. Predictors of Immunologic Long-term Non-Progression in Children with HIV
    Jintanat Ananworanich; Fiscal Year: 2010
  6. Phagosomal Signals Shape Inflammatory Responses to Borrelia Burgdorferi
    Juan C Salazar; Fiscal Year: 2010
  7. Jay Rappaport; Fiscal Year: 2014
  8. Katherine L Knight; Fiscal Year: 2016
  9. Makio Iwashima; Fiscal Year: 2014
  10. Immunobiology of Acute Environmental Asthma
    David B Peden; Fiscal Year: 2013

Detail Information

Publications294 found, 100 shown here

  1. pmc Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity
    Hans Rempel
    Department of Laboratory Medicine at the Veterans Affairs Medical Center, San Francisco, California, United States of America
    PLoS ONE 3:e1967. 2008
    ..Differential gene expression analysis of CD14(+) monocytes from subjects infected with HIV-1 revealed increased expression of sialoadhesin (Sn, CD169, Siglec 1), ..
  2. ncbi CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex
    Takashi Nakata
    Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Nishi 7, Kita 13, Kita ku, Sapporo 060 8586, Japan
    Cell Microbiol 8:1899-909. 2006
    ..However, cotransfection of CD14 drastically enhanced the recognition of triacylated lipopeptides by TLR2/TLR1...
  3. pmc Association between CD14 gene C-260T polymorphism and inflammatory bowel disease: a meta-analysis
    Zhengting Wang
    Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    PLoS ONE 7:e45144. 2012
    The gene encoding CD14 has been proposed as an IBD-susceptibility gene with its polymorphism C-260T being widely evaluated, yet with conflicting results...
  4. doi Serum sCD14, polymorphism of CD14(-260) and periodontal infection
    T Raunio
    Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Oulu 90014, Finland
    Oral Dis 15:484-9. 2009
    b>CD14 is a co-receptor involved in the recognition of Gram-negative and positive bacteria...
  5. doi Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE
    M A Tewfik
    Department of Otolaryngology Head and Neck Surgery, Montreal General Hospital, McGill University, Montreal, Canada
    Allergy 64:746-53. 2009
    ..We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE level...
  6. ncbi A promoter polymorphism in the CD14 gene is associated with elevated levels of soluble CD14 but not with IgE or atopic diseases
    M Kabesch
    University Children s Hospital, Ludwig Maximilian s University Munich, Munchen, Germany
    Allergy 59:520-5. 2004
    A polymorphism in the promoter region of the CD14 gene, C-159T, has been shown to be associated with increased levels of soluble CD14 (sCD14) and decreased serum immunoglobulin E (IgE) and the expression of a more severe atopic phenotype ..
  7. ncbi Monocyte antigen CD14 is a phospholipid anchored membrane protein
    D L Simmons
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Blood 73:284-9. 1989
    A cDNA clone encoding the human monocyte antigen CD14 was isolated by transient expression in COS cells of a cDNA library prepared from phorbol diester-treated HL60 cells...
  8. pmc Polymorphisms within inflammatory genes and colorectal cancer
    Stefano Landi
    Genetics Department of Biology, University of Pisa, Via S, Giuseppe 22, 56126, Pisa, Italy
    J Negat Results Biomed 5:15. 2006
    ..ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>..
  9. ncbi Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kappa B, ERK 1/2 and p38 MAPK in host monocytes
    Mingqun Lin
    Department of Veterinary Biosciences, 1925 Coffey Road, The Ohio State University, Columbus, OH 43210, USA
    Cell Microbiol 6:175-86. 2004
    ..E. chaffeensis infection caused downregulation of the expression of several pattern recognition receptors, such as CD14, TLR2 and TLR4, as revealed by flow cytometry and/or reverse transcription polymerase chain reaction analysis...
  10. doi Genetic variants in immunoregulatory genes and risk for childhood lymphomas
    Elisabeth Andrie
    Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, 75 Mikras Asias Str, Goudi, Athens, Greece
    Eur J Haematol 83:334-42. 2009
    ..nine genes with important role in immunoregulatory pathways (IL4, IL4R, IL6, IL10, IL12, IL18, TNFalpha, IFNgamma, CD14)...
  11. pmc Association of CD14 variant with prostate cancer in African American men
    Tshela E Mason
    National Human Genome Center at Howard University, Washington, DC 20059, USA
    Prostate 70:262-9. 2010
    ..Since genetic susceptibility is an etiological factor in prostate cancer, we hypothesize that sequence variants in the promoter region of the CD14 gene that regulate inflammation may modify individual susceptibility to this disease.
  12. pmc Role of polymorphic variants as genetic modulators of infection in neonatal sepsis
    Asmaa Abu-Maziad
    Department of Pediatrics, University of Iowa, Children s Hospital, Iowa City, Iowa 52242, USA
    Pediatr Res 68:323-9. 2010
    ..IL1B, and TNF), cytokine receptors (IL1RN), toll-like receptors (TLR2, TLR4, and TLR5), and cell surface receptors (CD14) were genotyped. Subjects were stratified into three groups (sepsis, suspected sepsis, and control)...
  13. pmc CD14 -159 C>T gene polymorphism with increased risk of tuberculosis: evidence from a meta-analysis
    M Y Areeshi
    Department of Medical Microbiology, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia
    PLoS ONE 8:e64747. 2013
    Cluster of differentiation 14 (CD14) gene is an important component of the human innate immune system and its role in tuberculosis (TB) has been sparsely documented...
  14. ncbi The CD14 region spanning amino acids 57-64 is critical for interaction with the extracellular Toll-like receptor 2 domain
    Daisuke Iwaki
    Department of Biochemistry, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Biochem Biophys Res Commun 328:173-6. 2005
    b>CD14 has been shown to enhance Toll-like receptor 2 (TLR2)-mediated signaling in response to peptidoglycan...
  15. pmc CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis
    You Chen Chao
    Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, China
    World J Gastroenterol 11:6043-8. 2005
    To investigate the relationship between genetic polymorphism of the CD14 promoter and the occurrence of alcoholic cirrhosis and alcoholic pancreatitis, and to challenge the conclusion made earlier that the patients with acute alcoholic ..
  16. ncbi Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients
    Qiusha Guo
    Department of Internal Medicine, Research Center of Digestive Diseases, Wuhan University Zhongnan Hospital, Wuhan, China
    J Gastroenterol Hepatol 21:92-7. 2006
    Toll-like receptor 4 and CD14 are components of the lipopolysaccharide receptor complex. Our study aimed to investigate an association between TLR4 Asp299Gly and CD14-260 polymorphisms in Chinese patients with colorectal cancer.
  17. ncbi Polymorphism of the heat-shock protein gene Hsp70-2, but not polymorphisms of the IL-10 and CD14 genes, is associated with the outcome of Crohn's disease
    Gergely Klausz
    Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Scand J Gastroenterol 40:1197-204. 2005
    ..Several previous studies have investigated the roles of CD14, heat-shock protein (Hsp)70 and IL-10 gene polymorphisms in the development of the disease...
  18. ncbi [Molecular studies in a population of children with bronchial asthma. I. Polymorphism in the promotor region of gene CD14]
    G Lis
    Kliniki Chorób Dzieci, Collegium Medicum UJ, Krakow
    Pneumonol Alergol Pol 69:265-72. 2001
    ..Surface expression of CD14, a marker of activation and differentiation of macrophages/monocytes, was suggested to protect against Th-2 response...
  19. ncbi Evaluation of the CD14 C-159 T polymorphism in the German Multicenter Allergy Study cohort
    C Sengler
    Department of Pediatric Pneumology and Immunology, Charite Humboldt University, Berlin, Germany
    Clin Exp Allergy 33:166-9. 2003
    ..region several candidate genes for atopy are localized such as the Th2 cytokines IL-4, IL-5 and IL-13, but also CD14, a receptor for LPS...
  20. ncbi Age-specific relationship between CD14 and atopy in a cohort assessed from age 8 to 25 years
    Anne R O'Donnell
    Department of Paediatrics, University of Western Australia, Children s Hospital Medical Centre, Perth, Australia
    Am J Respir Crit Care Med 169:615-22. 2004
    b>CD14 influences postnatal switching of T helper cell responses. CD14 C-159T has been associated with altered CD14 and IgE levels in cross-sectional studies...
  21. doi Lipopolysaccharide-binding protein and CD14 are increased in the bronchoalveolar lavage fluid of smokers
    V Regueiro
    Program Infection and Immunity, Fundació Caubet CIMERA Illes Balears, Recinto Hospital Joan March, Carretera Soller km 12, 07110 Bunyola, Spain
    Eur Respir J 33:273-81. 2009
    Lipopolysaccharide-binding protein (LBP) and CD14 contribute to the recognition of pathogens by cells, which triggers the activation of defence responses...
  22. ncbi Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 32:1188-95. 2002
    ..Incubation of PBMC with either anti-Toll-like receptor 4 (TLR4) or anti-CD14 blocking antibodies did not influence the production of cytokines induced by Chlamydia...
  23. doi The influences of CD14 -260C>T polymorphism on survival in ICU critically ill patients
    Paulo R V Fallavena
    Laboratório de Genética Humana e Molecular, Hospital Sao Lucas, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre, RS, Brazil
    Immunol Invest 38:797-811. 2009
    In order to analyze the effect of the two different versions of the cluster of differentiation 14 (CD14) receptor recognizing gene on survival, we determined the -260C>T single nucleotide polymorphism (SNP) frequencies in 514 ..
  24. doi Association between the CD14 gene C-159T polymorphism and serum soluble CD14 with pulmonary tuberculosis
    R Alavi-Naini
    Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
    Int J Tuberc Lung Dis 16:1383-7. 2012
    Functional C-159T polymorphism in the promoter region of the CD14 lipopolysaccharide receptor has been reported to be associated with the development of tuberculosis (TB).
  25. ncbi CD14 gene promoter polymorphism in different clinical forms of tuberculosis
    Eugenia Pacheco
    Grupo de Inmunologia Celular e Inmunogenetica, Facultad de Medicina, Universidad de Antioquia, Cra 51 D No 62 29 Lab 283 Medellín, Colombia
    FEMS Immunol Med Microbiol 40:207-13. 2004
    Mycobacterium tuberculosis interacts with monocyte-macrophages through cell surface molecules including CD14. A soluble form of CD14 (sCD14) exists in human serum, and higher amounts of it are found in tuberculosis...
  26. ncbi Lack of association of the CD14 promoter polymorphism--159C/T with Caucasian inflammatory bowel disease
    Kirsten E Peters
    John Curtin School of Medical Research, Australian National University, Woden, Australia
    Scand J Gastroenterol 40:194-7. 2005
    ..Other bacterial receptors, such as CD14, may also have a role in disease...
  27. ncbi Effects of CD14-159 C/T polymorphism on CD14 expression and the balance between proinflammatory and anti-inflammatory cytokines in whole blood culture
    Jing Lin
    Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, 51 Fu Cheng Road, Beijing 100037, P R China
    Shock 28:148-53. 2007
    b>CD14 is an important receptor of innate immunity. When CD14 is anchored by ligands to LPS, peptidoglycans, or lipoteichoic acid, it can result in either proinflammatory or anti-inflammatory responses...
  28. doi Toll-like receptors and CD14 genes polymorphisms and susceptibility to asthma in Tunisian children
    J Lachheb
    Homeostasis and Cell Dysfunction Unit Research 99 UR 08 40, Medicine University of Tunis, Tunis, Tunisia
    Tissue Antigens 71:417-25. 2008
    Many studies have shown the implication of CD14 and toll-like receptors (TLRs) 2, 4 and 9 in the pathogenesis of asthma or atopy...
  29. ncbi LPS receptor CD14 participates in release of TNF-alpha in RAW 264.7 and peritoneal cells but not in kupffer cells
    S N Lichtman
    Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599 7220, USA
    Am J Physiol 275:G39-46. 1998
    ..In macrophages (RAW 264.7 and peritoneal cells), LPS binds to the CD14 surface receptor as the first step toward signaling...
  30. pmc Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins
    R L Kitchens
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 108:485-93. 2001
    b>CD14, a myeloid cell-surface receptor and soluble plasma protein, binds LPS and other microbial molecules and initiates the innate immune response to bacterial invasion...
  31. ncbi Ulcerative colitis is associated with a promoter polymorphism of lipopolysaccharide receptor gene, CD14
    N Obana
    Dept of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Scand J Gastroenterol 37:699-704. 2002
    ..Evidence is accumulating that molecules such as CD14, which interact with luminal bacterial constituents, are involved in the pathogenesis...
  32. ncbi The -159 C-->T polymorphism of CD14 is associated with nonatopic asthma and food allergy
    Jessica G Woo
    Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati Medical Center, Ohio, USA
    J Allergy Clin Immunol 112:438-44. 2003
    b>CD14, the receptor for LPS, plays an important role in innate immunity. A polymorphism in the promotor for CD14, -159 C-->T, has been implicated in atopy.
  33. ncbi Association between the promoter polymorphism T/C at position -159 of the CD14 gene and anti-inflammatory therapy in patients with inflammatory bowel disease
    T Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Eur J Med Res 10:183-6. 2005
    ..A single nucleotide polymorphism in the promoter of the lipopolysaccharide-receptor CD14 gene (T/C at position -159) has recently been described...
  34. ncbi Time to abandon dogma: CD14 is expressed by non-myeloid lineage cells
    Hubertus P A Jersmann
    Lung Research Laboratory, Hanson Institute, University of Adelaide, Adelaide, South Australia, Australia
    Immunol Cell Biol 83:462-7. 2005
    b>CD14 is a pattern recognition receptor; its important role in innate immunity is reviewed here...
  35. ncbi Synergistic effect of Toll-like receptor 4 and CD14 polymorphisms on the total atherosclerosis burden in patients with peripheral arterial disease
    Tryfon Vainas
    Department of Surgery, Maastricht University Hospital, Maastricht, The Netherlands
    J Vasc Surg 44:326-32. 2006
    Genes involved in the regulation of immune responses, such as Toll-like receptor 4 (TLR4) and CD14, show genetic variations with potential functional implications...
  36. doi Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population
    M Y Zhao
    Institute of Cell Biology, Zhejiang University, Hangzhou, China
    Genet Mol Res 11:3425-31. 2012
    Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear...
  37. ncbi Lack of association between the -260 C-->T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels
    M Heesen
    Department of Anesthesiology and Intensive Care Medicine, University Hospital of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
    Intensive Care Med 27:1770-5. 2001
    b>CD14 is a receptor for endotoxin and binds components of Gram-positive and Gram-negative bacteria. CD14-bearing monocytes respond to stimulation with the increased synthesis and release of cytokines...
  38. ncbi Association of a promoter polymorphism of the CD14 gene and atopy
    G H Koppelman
    Department of Pulmonary Rehabilitation, Beatrixoord, Haren, The Netherlands
    Am J Respir Crit Care Med 163:965-9. 2001
    ..Recently, an association of a C-to-T transition in the promoter region of the CD14 gene on chromosome 5q31...
  39. ncbi Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction
    Eicke Latz
    University of Massachusetts Medical School, Division of Infectious Diseases, Worcester 01605, USA
    J Biol Chem 277:47834-43. 2002
    Mammalian responses to LPS require the expression of Toll-like receptor 4 (TLR4), CD14, and MD-2. We expressed fluorescent TLR4 in cell lines and found that TLR4 densely localized to the surface and the Golgi...
  40. ncbi The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children
    Ting Fan Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Pediatr Allergy Immunol 14:255-60. 2003
    Activation of macrophages through CD14 by microbes is crucial in inducing immunity by type 1 T helper cells...
  41. ncbi Suggestive evidence of association of C-159T functional polymorphism of the CD14 gene with atopic asthma in northern and northwestern Indian populations
    Mamta Sharma
    Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Mall Road, 110007, Delhi, India
    Immunogenetics 56:544-7. 2004
    b>CD14 is a lipopolysaccharide receptor known to be an important modulator of Th1-Th2 response during early childhood...
  42. ncbi Soluble CD14 receptor expression and monocyte heterogeneity but not the C-260T CD14 genotype are associated with severe acute pancreatitis
    Sakhawat H Rahman
    Academic Unit of Surgery, University of Leeds, General Infirmary, Leeds, West Yorkshire, UK
    Crit Care Med 32:2457-63. 2004
    Soluble CD14 is derived from a membrane glycoprotein, and it enhances endothelial cytokine responses to lipopolysaccharide...
  43. ncbi Association between decreased kidney function and endotoxin receptor CD14 C-159T polymorphism among Japanese health check-up examinees
    Rieko Okada
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Ren Fail 29:967-72. 2007
    A recently identified promoter polymorphism of the endotoxin receptor (CD14 C-159T) was shown to be associated with atherosclerotic diseases such as myocardial infarction...
  44. ncbi Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients
    K Kowal
    Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland
    J Investig Allergol Clin Immunol 18:284-92. 2008
    ..On the other hand, LPS induces PAI-1 secretion. Activation of individual cells by LPS is facilitated by CD14. The single nucleotide polymorphisms -675 4G/5G in SERPINE1 and C-159T in CD14 are major determinants of PAI-1 and ..
  45. pmc Human lactoferrin interacts with soluble CD14 and inhibits expression of endothelial adhesion molecules, E-selectin and ICAM-1, induced by the CD14-lipopolysaccharide complex
    S Baveye
    Laboratoire de Chimie Biologique et Unité Mixte de Recherche no 8576 du Centre National de la Recherche Scientifique, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Infect Immun 68:6519-25. 2000
    Lipopolysaccharides (LPS), either in the free form or complexed to CD14, a LPS receptor, are elicitors of the immune system. Lactoferrin (Lf), a LPS-chelating glycoprotein, protects animals against septic shock...
  46. pmc Induction of keratinocyte growth factor 1 Expression by lipopolysaccharide is regulated by CD-14 and toll-like receptors 2 and 4
    Edward E Putnins
    Department of Oral Biological and Medical Sciences University of British Columbia, Vancouver, Canada
    Infect Immun 70:6541-8. 2002
    ..of keratinocyte growth factor 1 protein expression was dependent on gingival fibroblast expression of membrane CD14 (mCD14) and Toll-like receptors 2 and 4...
  47. ncbi Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1
    Khalid Sendide
    Department of Medicine, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada
    J Immunol 174:4210-9. 2005
    The glycosylphosphatidyl anchored molecule CD14 to the monocyte membrane plays a prominent role in innate immunity, and the paradigms for CD14 selective signaling are beginning to be elucidated...
  48. ncbi LPS/CD14 activation triggers SGLT-1-mediated glucose uptake and cell rescue in intestinal epithelial cells via early apoptotic signals upstream of caspase-3
    Linda C H Yu
    Department of Biological Sciences, BI 117 Mucosal Inflammation Research Group, University of Calgary, 2500 University Dr N W, Calgary, AB, T2N 1N4, Canada
    Exp Cell Res 312:3276-86. 2006
    ..Immunofluorescence staining showed expression of CD14 on the apical surface, but no TLR-4, on these cells...
  49. ncbi Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3
    Jürgen Schauber
    Division of Dermatology, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA
    J Invest Dermatol 128:816-24. 2008
    ..of histone deacetylase inhibitors (HDACi) (butyrate or trichostatin A) and 1,25D3 increased cathelicidin and CD14 expression and enhanced the antimicrobial function of keratinocytes against Staphylococcus aureus...
  50. doi High glucose enhances lipopolysaccharide-stimulated CD14 expression in U937 mononuclear cells by increasing nuclear factor kappaB and AP-1 activities
    Alena Nareika
    Division of Endocrinology, Diabetes and Medical Genetics, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29401, USA
    J Endocrinol 196:45-55. 2008
    ..Since CD14 is a receptor for LPS, one potential underlying mechanism is that high glucose enhances CD14 expression...
  51. doi Myeloid cell differentiation in response to calcitriol for expression CD11b and CD14 is regulated by myeloid zinc finger-1 protein downstream of phosphatidylinositol 3-kinase
    Alireza Moeenrezakhanlou
    Department of Medicine Division of Infectious Diseases, University of British Columbia, Rm 452D, 2733 Heather St, Vancouver, BC V5Z 3J5, Canada
    J Leukoc Biol 84:519-28. 2008
    ..This is accompanied by increased expression of both CD11b and CD14 and has been shown to be phosphatidylinositol 3-kinase (PI3K) dependent...
  52. doi Frequencies of genetic polymorphisms of TLR4 and CD14 and of HLA-DQ genotypes in children with celiac disease, type 1 diabetes mellitus, or both
    A Dezsofi
    First Department of Pediatrics, Semmelweis University, Hungary
    J Pediatr Gastroenterol Nutr 47:283-7. 2008
    ..T1DM) frequently coexist because of a common genetic predisposition, our aim was to study the frequency of CD14 C-260T and TLR4 A+896G single nucleotide polymorphisms (SNPs) and the distribution of HLA-DQ genotypes in children ..
  53. pmc The Toll-like receptor 2 (TLR2) ligand FSL-1 is internalized via the clathrin-dependent endocytic pathway triggered by CD14 and CD36 but not by TLR2
    Haque M Shamsul
    Laboratory of Oral Molecular Microbiology, Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Japan
    Immunology 130:262-72. 2010
    ..FSL-1 was internalized by human embryonic kidney 293 cells transfected with CD14 or CD36 but not by the non-transfected cells...
  54. ncbi Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections
    Doreen M Agnese
    Division of Surgical Sciences, Department of Surgery, University of Medicine and Dentistry New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Infect Dis 186:1522-5. 2002
    Human toll-like receptor 4 (hTLR4) and CD14 are known to be components of the lipopolysaccharide receptor complex...
  55. ncbi CD14 promoter polymorphism -159C>T is associated with susceptibility to chronic Chlamydia pneumoniae infection in peripheral blood monocytes
    J Rupp
    Institute of Medical Microbiology and Hygiene, University of Luebeck, Germany
    Genes Immun 5:435-8. 2004
    ..PBMC) for systemic dissemination and has been linked to atherogenesis by inflammation mediated via TLR2/4 and CD14. We found 12...
  56. ncbi The -159C/T polymorphism in the promoter region of the CD14 gene is associated with advanced liver disease and higher serum levels of acute-phase proteins in heavy drinkers
    Joaquin Campos
    Department of Internal Medicine, Hospital Clinico Universitario, Fundación Pública Gallega de Medicina Genómica, Santiago de Compostela, Spain
    Alcohol Clin Exp Res 29:1206-13. 2005
    ..A single-nucleotide polymorphism (-159C/T) in the promoter region of the gene coding for CD14 (a lipopolysaccharide receptor) could be associated with the development of ALD...
  57. ncbi Atopy and new-onset asthma in young Danish farmers and CD14, TLR2, and TLR4 genetic polymorphisms: a nested case-control study
    L A M Smit
    Division Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Clin Exp Allergy 37:1602-8. 2007
    ..Genetic variation in innate immunity genes may modulate the response to microbial agents and thus influence susceptibility to asthma and atopy...
  58. pmc Effect of CD14 promoter polymorphism and H. pylori infection and its clinical outcomes on circulating CD14
    J Karhukorpi
    Department of Medical Microbiology, University of Oulu, Finland
    Clin Exp Immunol 128:326-32. 2002
    b>CD14 is a pattern recognition receptor on the membranes of monocytes and macrophages for several microbial products, of which lipopolysaccharide (LPS) is the best known. A shed form of CD14 is present in serum...
  59. ncbi Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate
    Sebastien Gibot
    Service de Reanimation Medicale, Hopital Central, Nancy, France
    Crit Care Med 30:969-73. 2002
    Genetic differences in immune responses may affect susceptibility to and outcome of septic shock. CD14 seems to be an important part of the innate immune system, initiating antimicrobial response...
  60. ncbi The CD14-260 C --> T promoter polymorphism co-segregates with the tumor necrosis factor-alpha (TNF-alpha)-308 G --> A polymorphism and is associated with the interleukin-1 beta (IL-1 beta) synthesis capacity of human leukocytes
    Michael Heesen
    Department of Anesthesia, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands
    Eur Cytokine Netw 13:230-3. 2002
    ..Genotyping for the TNF-alpha -308 and the CD14 -260 C/T promoter polymorphisms was carried out by real-time polymerase chain reaction assay using specific ..
  61. ncbi CD14-dependent clearance of apoptotic cells by human macrophages: the role of phosphatidylserine
    A Devitt
    MRC Center for Inflammation Research, University of Edinburgh, UK
    Cell Death Differ 10:371-82. 2003
    Apoptotic-cell clearance is dependent on several macrophage surface molecules, including CD14. Phosphatidylserine (PS) becomes externalised during apoptosis and participates in the clearance process through its ability to bind to a novel ..
  62. ncbi Single-nucleotide polymorphism in the CD14 promoter and periodontal disease expression in a Japanese population
    K Yamazaki
    Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 5274, Gakkocho Dori 2 ban cho, Niigata 951 8514, Japan
    J Dent Res 82:612-6. 2003
    ..reported that there is a relationship between a single-nucleotide polymorphism (SNP) in the promoter region of the CD14 gene at position -159 (C-->T) and infectious diseases...
  63. ncbi Soluble CD14 and aortic stiffness in a population-based study
    Jacques Amar
    Service de Médecine Interne et d Hypertension artérielle, CHU Toulouse, INSERM 558, Toulouse, France
    J Hypertens 21:1869-77. 2003
    Soluble CD14 (sCD14), an effective mediator for the activation of monocytes by bacterial endotoxin is involved in the release of substances able to modify the characteristics of the arterial wall...
  64. ncbi Two CD14 promoter polymorphisms and atopic phenotypes in Czech patients with IgE-mediated allergy
    D Buckova
    Masaryk University Brno, Institute of Pathological Physiology LF MU, Brno, Czech Republic
    Allergy 58:1023-6. 2003
    ..The gene encoding CD14 is a positional candidate gene for allergic diseases as it is localized on chromosome 5q31...
  65. ncbi Association of the -159 C --> T polymorphism in the CD14 promoter with variations in serum lipoproteins in healthy subjects
    Karl Erik Eilertsen
    Department of Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø, Norway
    Blood Coagul Fibrinolysis 14:663-70. 2003
    The CD14-159 C --> T polymorphism, a single nucleotide polymorphism (SNP) at position -159 in the promoter region of the gene encoding the pattern recognition receptor CD14, has been associated with elevated plasma concentrations of ..
  66. ncbi CD14 is an acute-phase protein
    Sylvette Bas
    Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    J Immunol 172:4470-9. 2004
    The origin of soluble CD14 (sCD14) in the circulation is uncertain...
  67. ncbi Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis
    Helga Paula Török
    Medizinische Klinik und Medizinische Poliklinik, Standort Innenstadt, Klinikum der Universitat Munchen, 80336 Munich, Germany
    Clin Immunol 112:85-91. 2004
    ..and Thr399Ile) resulting in impaired lipopolysaccharide signaling, the -159C/T promotor polymorphism of the CD14 gene, polymorphisms of the lipopolysaccharide binding protein gene and the bactericidal permeability increasing ..
  68. pmc TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury
    R C Barber
    The Department of Surgery, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9160, USA
    J Med Genet 41:808-13. 2004
    ..The inability of clinical factors to identify at-risk patients suggests that genetic variation may influence the risk for serious infection and the outcome from severe injury...
  69. ncbi Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study
    April Zambelli-Weiner
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 115:1203-9. 2005
    Both a functional promoter polymorphism in the gene encoding CD14 (C-260T) and exposure to endotoxin are believed to play key roles in modulating the immune response and expression of atopic disease.
  70. pmc Association of polymorphisms of IL and CD14 genes with acute severe pancreatitis and septic shock
    Dian liang Zhang
    Department of General Surgery, Affiliated Hospital, Qingdao University Medial College, Qingdao 266003, Shandong Province, China
    World J Gastroenterol 11:4409-13. 2005
    To investigate IL-1beta+3 594 in the 5th intron, IL-10-1 082 and CD14-159 polymorphisms in patients with acute pancreatitis (AP) and septic shock.
  71. ncbi Promoter polymorphism of the CD14 endotoxin receptor gene is associated with biliary atresia and idiopathic neonatal cholestasis
    Hsiang Hung Shih
    Department of Pediatrics, Chang Gung Memorial Hospital at Chiayi, Pu Tz City, Chiayi Hsien, Taiwan
    Pediatrics 116:437-41. 2005
    To investigate whether single-nucleotide polymorphisms in the promoter regions of endotoxin-responsive genes CD14 and tumor necrosis factor-alpha (TNF-alpha) are associated with biliary atresia (BA) and idiopathic neonatal cholestasis (..
  72. ncbi Polymorphisms of CARD15/NOD2 and CD14 genes in New Zealand Crohn's disease patients
    Euphemia Leung
    Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Immunol Cell Biol 83:498-503. 2005
    ..Other potential susceptibility genes such as CD14 may compound the risk of developing CD...
  73. pmc Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection
    C Meiler
    Department of Internal Medicine I, University of Regensburg, Regensburg D 93042, Germany
    World J Gastroenterol 11:6031-7. 2005
    ..Recently, a C-T (-159) polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver ..
  74. ncbi Effect of CD14 -260C>T polymorphism on the mortality of critically ill patients
    Luiz C D'Avila
    Biosciences Faculty and São Lucas Hospital, Catholic Pontifical University of Rio Grande do Sul, Porto Alegre, Brazil
    Immunol Cell Biol 84:342-8. 2006
    The CD14 receptor seems to be an important part of the innate immune system...
  75. pmc Association of CD14 promoter polymorphism with otitis media and pneumococcal vaccine responses
    S P Wiertsema
    Department of Pediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Vaccine Immunol 13:892-7. 2006
    ..b>CD14 plays key roles in innate immunity, including in defense against pathogens associated with otitis media, a major ..
  76. ncbi Failure to find an association between CD14-159C/T polymorphism and asthma: a family-based association test and meta-analysis
    Fumichika Nishimura
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Allergol Int 55:55-8. 2006
    b>CD14 is an essential component of the receptor for lipopolysaccharide (LPS). LPS stimulates T-helper type 1 (Th1) cytokine expression, potentially suppressing Th2 immune responses involved in IgE-mediated allergic diseases...
  77. ncbi Role of CD14 promoter polymorphisms in Helicobacter pylori infection--related gastric carcinoma
    Dan Zhao
    Department of Etiology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Clin Cancer Res 13:2362-8. 2007
    Genetic variation in CD14 may affect CD14 expression and susceptibility to Helicobacter pylori infection-related cancers...
  78. ncbi Genetic polymorphisms of CD14 and Toll-like receptor-2 (TLR2) in patients with ulcerative colitis
    Fangyu Wang
    Department of Gastroenterology, School of Medicine, Fujita Health University, Toyoake, Japan
    J Gastroenterol Hepatol 22:925-9. 2007
    ..The aim of this study was to investigate the association between CD14 and Toll-like receptor-2 (TLR2) genetic polymorphisms and chronic UC in Japanese patients.
  79. pmc Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis
    Kristine Marie Jessen
    Clinical Research Unit, Hvidovre University Hospital, Copenhagen, Denmark
    BMC Infect Dis 7:108. 2007
    ..Only few studies have combined the analysis of multiple SNPs in the same population...
  80. ncbi CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis
    Adrian G Rosas-Taraco
    Departamento Inmunologia, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Nuevo Leon, 64460, Mexico
    J Infect Dis 196:1698-706. 2007
    Neither the expression of CD14 and Toll-like receptor 4 (TLR4) on monocytes' surface nor the mutations CD14 -159TT and TLR4 Asp299Gly have yet been evaluated as risk factors for development of pulmonary tuberculosis (TB) in the Mexican ..
  81. doi The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease
    Daniel C Baumgart
    Division of Gastroenterology and Hepatology, Department of Medicine, Charite Medical School, Humboldt University of Berlin, Berlin, Germany
    Digestion 76:196-202. 2007
    ..Therefore, the study of candidate genes involved in host pathogen interactions is of key interest...
  82. doi Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study
    R W B Bottema
    Dept of Pulmonology, University Medical Center Groningen, P O Box 196, 9700 AD Groningen, The Netherlands
    Eur Respir J 32:593-602. 2008
    ..Haplotype-tagging polymorphisms in the genes interleukin (IL)13 and CD14 were genotyped in 3,062 children from the following birth cohorts: the Prevention and Incidence of Asthma and Mite ..
  83. doi 159C>T CD14 genotype--functional effects on innate immune responses in term neonates
    Christoph Hartel
    Department of Pediatrics, University at Lubeck, Lubeck, Germany
    Hum Immunol 69:338-43. 2008
    ..We studied the functional relevance of the 159C>T CD14 single nucleotide polymorphism in cord blood samples of n=135 healthy term neonates by investigation of sCD14, ..
  84. doi Functional significance of CD14 promoter polymorphisms and their clinical relevance in a Chinese Han population
    Wei Gu
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    Crit Care Med 36:2274-80. 2008
    Several polymorphisms in the CD14 promoter have been reported to be associated with various inflammatory diseases. However, conflicting results have been shown in association studies in different populations...
  85. doi CD14 expression in the first 24h of sepsis: effect of -260C>T CD14 SNP
    Bibiana Butkus de Aguiar
    Faculdade de Biociências and Hospital São Lucas HSL, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Brazil
    Immunol Invest 37:752-69. 2008
    Sepsis is defined as systemic inflammation caused by infection. The membrane bound CD14 (mCD14) or the soluble form (sCD14) play a crucial role facing Gram-negative and Gram-positive sepsis since they are pattern recognition receptors of ..
  86. doi CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults
    Lidwien A M Smit
    INSERM U780, Villejuif, France
    Am J Respir Crit Care Med 179:363-8. 2009
    ..It has been shown that country living protects against asthma, which may be explained by microbial exposures...
  87. doi CD14 C-260T gene polymorphism and ischemic heart disease susceptibility: a HuGE review and meta-analysis
    Hai Feng Zhang
    Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University, Guangxi, China
    Genet Med 11:403-8. 2009
    The CD14 gene C-260T polymorphism has been reported to be associated with ischemic heart disease, but results were conflicting...
  88. pmc CD14 C-159T and toll-like receptor 4 Asp299Gly polymorphisms in surviving meningococcal disease patients
    Ariane Biebl
    Department of Pediatrics, University Teaching Hospital, Feldkirch, Austria
    PLoS ONE 4:e7374. 2009
    ..The functional single nucleotide polymorphisms (SNPs) CD14 C-159T and toll-like receptor 4 (TLR4) Asp299Gly have been associated with the risk of gram-negative infections...
  89. pmc Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases
    Veronica Marcos
    Children s Hospital of the Ludwig Maximilians University, Munich, Germany
    Respir Res 11:32. 2010
    ..Bacterial lipopolysaccharide (LPS) is recognized via Toll-like receptors and CD14. CD14 exists as a soluble (sCD14) and membrane-associated (mCD14) protein, present on the surface of leukocytes...
  90. doi Genetic polymorphism of manganese superoxide dismutase is associated with childhood asthma
    Tsai Nung Kuo Chou
    Institute of Medicine, College of Health Care and Management, Chung Shan Medical University Hospital, Taichung, Taiwan
    J Asthma 47:532-8. 2010
    ..b>CD14 is a receptor for various bacterial products, such as lipopolysaccharides (LPS), and is also a mediator of ..
  91. pmc Association between toll-like receptors/CD14 gene polymorphisms and inflammatory bowel disease in Korean population
    Eun Jung Kim
    Department of Internal Medicine, St Vincent Hospital, The Catholic University of Korea, Suwon, Korea
    J Korean Med Sci 27:72-7. 2012
    ..However, the exact role of Toll-like receptors (TLRs) / CD14 gene in the pathogenesis of IBD has not been fully elucidated...
  92. doi Association between CD14-159C>T polymorphisms and the risk for alcoholic liver disease: a meta-analysis
    Tao Zeng
    Institute of Toxicology, School of Public Health, Shandong University, Jinan, People s Republic of China
    Eur J Gastroenterol Hepatol 25:1183-9. 2013
    The association between CD14-159C>T polymorphisms and alcoholic liver disease (ALD) risk has been investigated in many studies, but the results were inconsistent...
  93. pmc Association between CD14 promoter -159C/T polymorphism and the risk of sepsis and mortality: a systematic review and meta-analysis
    An qiang Zhang
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
    PLoS ONE 8:e71237. 2013
    Recent studies on the association between CD14-159C/T polymorphism and sepsis showed inconclusive results...
  94. ncbi The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors
    S M Goyert
    Department of Rheumatic Diseases, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003
    Science 239:497-500. 1988
    b>CD14 is a myelomonocytic differentiation antigen expressed by monocytes, macrophages, and activated granulocytes and is detectable with the monoclonal antibodies MO2, MY4, and LeuM3...
  95. ncbi The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage
    A Haziot
    Cellular and Molecular Biology Unit, Hospital for Joint Diseases, New York 10003
    J Immunol 141:547-52. 1988
    b>CD14 is a myeloid differentiation Ag expressed primarily on peripheral blood monocytes and macrophages. Although its function is unknown, the CD14 gene maps to a region encoding several myeloid growth factors and receptors...
  96. ncbi Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
    A Haziot
    Division of Molecular Medicine, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030, USA
    Immunity 4:407-14. 1996
    ..b>CD14, a GPI-anchored glycoprotein expressed strongly by monocyte/macrophages, is one of several receptors for endotoxin/..
  97. ncbi Human CD14 mediates recognition and phagocytosis of apoptotic cells
    A Devitt
    Department of Immunology, University of Birmingham Medical School, UK
    Nature 392:505-9. 1998
    ..Here we show that the glycosylphosphatidylinositol-linked plasma-membrane glycoprotein CD14 on the surface of human macrophages is important for the recognition and clearance of apoptotic cells...
  98. ncbi Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease
    H A Järveläinen
    Alcohol Research Center, National Public Health Institute, Finland
    Hepatology 33:1148-53. 2001
    ..Activated Kupffer cells release proinflammatory cytokines, a process that is regulated by the CD14 endotoxin receptor (CD14)...
  99. ncbi A polymorphism in the CD14 gene is associated with Crohn disease
    W Klein
    Abteilung fuer Molekulare Humangenetik, Ruhr Universitaet, Bochum, Germany
    Scand J Gastroenterol 37:189-91. 2002
    ..Although genetic factors play an important role in the pathogenesis, little is known about the genes accountable. Immune response to intestinal bacteria seems to be crucial in the pathogenesis of IBD...
  100. ncbi TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires sCD14
    Fredrik Backhed
    Microbiology and Tumorbiology Center, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Cell Microbiol 4:493-501. 2002
    ..The TLR4-mediated LPS response in bladder epithelial cells also uses the co-receptor CD14 for efficient LPS signalling...
  101. ncbi The -260 C-->T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients
    Michael Heesen
    Department of Anesthesia, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Postbus 22660, 1100 DD Amsterdam, The Netherlands
    Intensive Care Med 28:1161-3. 2002
    b>CD14, expressed on the cell surface of monocytes and hepatic Kupffer cells, interacts with Gram-positive and Gram-negative bacteria...

Research Grants65

  1. Role of CD14 and other innate immune receptors in severe sepsis
    Sanna M Goyert; Fiscal Year: 2012
    ..In addition, we show that the LPS receptor, CD14, plays a major role in delaying the recruitment of PMN since deletion of this gene allows early recruitment and ..
  2. ROLE OF THE CD14 LPS RECEPTOR IN CORNEAL INFLAMMATION
    JOHN ANSEL; Fiscal Year: 2004
    ..This application will test the hypothesis that corneal cells express functional CD14 receptors that, when activated by LPS, are capable of triggering the expression of proinflammatory peptides which ..
  3. CHARACTERIZATION OF THE LPS RECEPTOR FOR ACUTE PHASE
    Sanna Goyert; Fiscal Year: 2002
    ..of APP results from a secondary effect of cytokines secreted by macrophages when LPS stimulates them through the CD14-LPS receptor...
  4. Vasoprotective Actions of Autologous Cell Transfer
    Robert Simari; Fiscal Year: 2007
    ..Following 7 days in culture, the majority of early CMMCs express CD14 (the LPS receptor and a monocyte marker) although this heterogenous population also includes precursors to ..
  5. Predictors of Immunologic Long-term Non-Progression in Children with HIV
    Jintanat Ananworanich; Fiscal Year: 2010
    ..3 years: CDS, CD4, CDS, CD19, CD16/56, CD4/45RA/62L, CD8/45RA/62L, CD4/DR/38, CD8/DR/38, CD3/4/45RO, CD3/4-/45RO, CD14/16/DR and CD14/16/163 The primary objectives and hypotheses are to 1) Determine if children randomized to deferred ..
  6. Phagosomal Signals Shape Inflammatory Responses to Borrelia Burgdorferi
    Juan C Salazar; Fiscal Year: 2010
    ..as a result of the interactions of the spirochete's abundant outer membrane-associated lipoproteins with CD14 and Toll-like receptors (TLR) 1/2 on the surface of these cells...
  7. Jay Rappaport; Fiscal Year: 2014
    ..Our previous studies have identified the accumulation of a monocyte subset (CD14+/CD163+/CD16+) in peripheral blood in patients with HIV infection and SIV infected rhesus macaques...
  8. Katherine L Knight; Fiscal Year: 2016
    ..We have recently identified two populations of monocytes (CD14+) in cord blood, CD36hi and CD36lo and shown that the CD36hi monocytes drive development of regulatory T (Treg) ..
  9. Makio Iwashima; Fiscal Year: 2014
    ..We have recently identified two populations of monocytes (CD14+) in cord blood, CD36hi and CD36low and shown that the CD36hi monocytes drive development of regulatory T (Treg) ..
  10. Immunobiology of Acute Environmental Asthma
    David B Peden; Fiscal Year: 2013
    ..We have shown that endotoxin causes changes in airway monocytes and macrophages (increased CD14, CD80, Fc?RI and HLA-DR) which are associated with enhanced response to either innate or acquired immune stimuli...
  11. Sharilyn Almodovar; Fiscal Year: 2014
    ..The applicant and others have shown that classic CD14+ monocytes do not carry HIV during suppressive HAART and CD16+ pro- inflammatory monocytes in peripheral blood ..
  12. Erica L Herzog; Fiscal Year: 2016
    ..surface expression of Sema 7a on CD4+ lymphocytes, and mRNA expression of [unreadable]1 integrin and Netrin-1 in CD14+ monocytes, is enhanced in the circulation of subjects with IPF. Plexin C1 is not increased...
  13. Inflammatory Mechanisms and Treatment Strategies for Atherosclerosis in HIV
    STEVEN KYLE GRINSPOON; Fiscal Year: 2013
    ..HIV infection causes alterations in the monocyte repertoire with expansion of the proinflammatory CD14+CD16+ monocyte subset and T lymphocyte activation...
  14. Juan C Salazar; Fiscal Year: 2015
    ..as a result of the interactions of the spirochete's abundant outer membrane-associated lipoproteins with CD14 and Toll-like receptors (TLR) 1/2 on the surface of these cells...
  15. Role of IRAK-M in sepsis-induced immunosuppression
    Jane C Deng; Fiscal Year: 2010
    ..The specific aims of this, proposal are to: 1) assess the time-dependent expression of TLR4, CD14, and IRAK-M in alveolar and pulmonary macrophages following CLP;2) determine the functional significance of IRAK-M ..
  16. Michal Mrug; Fiscal Year: 2016
    ..While we have identified C3, macrophage marker CD14 and C3-inducible factor MCP-1 as candidate predictors of PKD outcomes, others have demonstrated that macrophage ..
  17. HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function
    Bruce T Shiramizu; Fiscal Year: 2010
    ..Our preliminary investigation also suggests that the high PBMC HIV DNA is specifically within CD14*VCD16+ monocytes/macrophages (M/MO) rather than CD14+/CD16" M/Mct>or lymphocytes (CD14")...
  18. Vitamin D Regulation of CD14 in Mammary Epithelial Cells
    KATRINA MARIE SIMMONS; Fiscal Year: 2013
    ..provided by applicant): The current project will investigate the regulation of an innate immunological protein, CD14, by vitamin D in mammary epithelial cells...
  19. John F Sheridan; Fiscal Year: 2016
    ..a primed phenotype with increased surface expression of several inflammatory markers, including CD86, TLR4, and CD14 (J. Neuroscience 2011, in press)...
  20. KATHLEEN ELIZABETH JAEGER; Fiscal Year: 2014
    ..This Treg inducing subset is characterized by their high expression of both the myeloid lineage marker CD14 and the scavenger receptor CD36 (CD36HI monocytes)...
  21. Elena Tourkina; Fiscal Year: 2016
    ..and signaling and thereby regulates the trafficking of monocytes and fibrocytes;2) Determine whether CXCR4/CD14/TLR4 receptor complexes differ in prevalence and function in Normal and SSc monocytes and the role of caveolin-1 in ..
  22. Douglas T Golenbock; Fiscal Year: 2016
    ..challenges the concept that malarial glycosylphosphatidylinositol (GPI)-lipid anchors, which are primarily TLR2/CD14 agonists, are the primary cause of systemic inflammation in malaria...
  23. Oral Pathogen Exploitation of Innate Recognition as a Function of Age
    GEORGIOS HAJISHENGALLIS; Fiscal Year: 2011
    ..P. gingivalis interacts via its surface fimbriae with the CD14/Toll-like receptor 2 recognition complex and induces phosphatidylinositol-3-kinase signaling for activating the ..
  24. Walter Royal; Fiscal Year: 2014
    ..Building on the confluence of new information showing that CD14-positive Monocyte-associated HIV DNA Viral Load (CD14MADVL) correlates with NCI, coupled to unpublished data from ..
  25. KLF4, myeloid development, and transplantation arteriosclerosis
    A K M KHYRUL WARA; Fiscal Year: 2010
    ..of KLF4 alone in the human promyelocytic cell line, HL-60, confers the morphologic, genetic (M-CSFR, CD11b, CD14), and functional (adhesion and phagocytosis) characteristics of a mature monocyte...
  26. MARIA BARTOLOMEO GRANT; Fiscal Year: 2014
    ..a clonal phenotype and belong to a CD34+CD45- population;and early EPCs (eEPCs) which exhibit a monocyte phenotype (CD14+/CD45+) but demonstrate endothelial-like markers and behavior in vitro and in vivo...
  27. ANDRA LEAH BLOMKALNS; Fiscal Year: 2015
    ..The proposed research will focus on the CD14 receptor in AAA formation where the Applicant has preliminary data to show that CD14 is necessary for AAA formation ..
  28. HIV DNA in CNS Compartments Relation to HIV-Associated Neurocognitive Disorders
    MELISSA ANNE AGSALDA; Fiscal Year: 2010
    ..Based on research in our laboratory, we hypothesize that CD14+/CD16+ monocytes are important viral reservoirs that play a role in HAND neuro-pathogenesis...
  29. The Regulation of Inflammatory Gene Responses in Aging
    MATTHEW THOMAS RONDINA; Fiscal Year: 2012
    ..We will also characterize shifts from a classical (CD14+/CD16-) to a non-classical, pro-inflammatory monocyte population (CD14+/CD16+) that occur during the aging process...
  30. Shukti Chakravarti; Fiscal Year: 2016
    ..Lumican itself binds LPS that can be removed competitively by CD14, the cell surface protein that transfers LPS to toll-like receptor 4, the trans-membrane IPS receptor...
  31. M. tuberculosis lipoprotein-TLR2 interactions
    Clifford V Harding; Fiscal Year: 2011
    ..dependence (use of TLR1 or TLR6 as co-receptors in heterodimers with TLR2, as well as use of accessory receptors, CD14 and CD36)...
  32. LH ACTION IN OVARIAN CELL DIFFERENTIATION
    JoAnne S Richards; Fiscal Year: 2013
    ..surveillance response system, including the Toll-like receptors TLR2 and TLR4 and components of this system (C1q, Cd14, and Pdcd1) uniquely expressed in cumulus cells...
  33. DEVELOPMENT AND CHARACTERIZATION OF CD14 DEFICIENT MICE
    Kathryn Moore; Fiscal Year: 2005
    DESCRIPTION (Adapted from the applicant's abstract): CD14 is a 55 kDa glycosyl phosphatidylinositol-linked protein that is also present in a soluble form in serum...
  34. Microglial Signaling Mechanisms in Alzheimer's Disease
    Gary E Landreth; Fiscal Year: 2010
    ..We provide preliminary data that the Abeta receptor complex includes CD14, an unexpected role for this lipopolysaccharide (LPS) receptor...
  35. CD14: Biosynthesis, Trafficking and Secretion
    DIEGO FERNANDO NINO; Fiscal Year: 2013
    ..In this complex, CD14 is the major binding site for LPS whereas TLR4 is involved in the signal transduction responsible for the ..
  36. The Role of TLR4 and RSV F Protein in Immunity to RSV
    JORGE C BLANCO; Fiscal Year: 2013
    ..vitro, purified F protein activation of NF-[unreadable]B and IL-8 secretion in HEK293T cells is TLR4-, MD-2-, and CD14-dependent, and transfectants that express TLR4 proteins with one or both of two single nucleotide polymorphisms (..
  37. HUCBC modulation of Alzheimer's-like pathology and behavioral changes
    Jun Tan; Fiscal Year: 2012
    ..very weakly immunogenic due to their immature or complete lack of, hematopoietic and endothelial markers such as CD14, CD34, CD45 and CD31...
  38. Pathophysiology of sepsis-induced renal injury
    Pierre C Dagher; Fiscal Year: 2013
    ..In specific aim 2, we will determine the roles of TLR4, CD14 and receptor-independent fluid-phase endocytosis in tubular endotoxin uptake with the powerful tool of targeted ..
  39. Lobelia Samavati; Fiscal Year: 2016
    ..leads to failure of MKP-1 induction;2- To determine the frequency of active p38 in patients with sarcoidosis in CD14+ AMs and to test the hypothesis that CD14+ peripheral blood mononuclear cells (PBMCs) parallel to p38 phenotype of ..
  40. Role of Macrophage Regulatory Cells (Mac-regs) in Immune Regulation
    Joseph Lustgarten; Fiscal Year: 2010
    ..Additionally, subpopulation of human CD14+ cells also expressed constitutively FOXP3...
  41. Marie E Egan; Fiscal Year: 2014
    ..In concert with accessory LPS-binding proteins including MD-2 and CD14, and TLR4 signaling plays a major role in the activation of the innate immune response to PA...
  42. Marisa Roberto; Fiscal Year: 2016
    ..the hypothesis of a role for neuroinflammatory factors (lipopolysaccharide {LPS}, toll-like receptor 4 {TLR4}, CD14, cytokines) in alcohol preference and excessive drinking...
  43. Immune Responses to Schistosome Egg Antigens
    Donald A Harn; Fiscal Year: 2010
    ..In addition, by transfecting HEK cells expressing TLR4/CD14/MD2 with these same C-type lectins we will determine if activation of APes via these lectins alters Toll-like ..
  44. Defining non-transcriptional innate immune responses to bacterial endotoxin
    Jonathan C Kagan; Fiscal Year: 2013
    ..Rather TLR4 is cargo for an endocytosis pathway that is activated by the LPS-binding protein CD14. While TLR4 does not direct its own endocytosis, this process is essential for TLR4 to induce TRIF-dependent signal ..
  45. MCP-1 and susceptibility to active tuberculosis
    PEDRO FLORES VILLANUEVA; Fiscal Year: 2003
    ..extend our preliminary studies to characterize in vitro the effect of MCP-l in alphaVbeta33 and CD44 Opn receptors, CD14 and TLR-2, and CD40 and CD154 expression and its relevance in the modulation of IL-12, MCP-l, IL-10, and Opn ..
  46. Early Environmental Hygiene and Pediatric Asthma
    Christine C Johnson; Fiscal Year: 2009
    ..biomarkers and asthma, after accounting for other non-modifiable and modifiable risk factors including CD14 genotype, family history, child sex, birth order, birth characteristics, socioeconomic status, and other social, ..
  47. Chandrashekhar R Gandhi; Fiscal Year: 2016
    ..production of the factors by HSCs that cause hepatocyte apoptosis is not mediated by the known pathways involving CD14, LPS-binding protein (LBP) and Toll-like receptor 4 (TLR4), and is very novel...
  48. Impact of genetic variation TLR/CD14 pathways and smoking in RA
    TED RICHARD MIKULS; Fiscal Year: 2011
    ..There is increasing data that genetic variation in CD14 and Toll-like receptors (TLRs) (pattern recognition receptors found on inflammatory cells) may explain variability ..
  49. The Role of Direct Pathogen Detection by Sensory Neurons in Combating Bacterial I
    ISAAC MING CHENG CHIU; Fiscal Year: 2012
    ..Nociceptor neurons express the co-receptors for LPS, CD14 and Toll-like Receptor 4 (TLR4)...
  50. HIV and Global Drug Therapies: Peripheral Neuropathy Complications and Mechanisms
    Cecilia M Shikuma; Fiscal Year: 2012
    ..We will also assess its relationship to levels of HIV DNA within the CD14+ sub-fraction of PBMCs which we hypothesize represent HIV-infected M/M7s responsible for the inflammation ..
  51. Jerrold Weiss; Fiscal Year: 2014
    ..action of several extracellular and cell surface host proteins, including lipopolysaccharide-binding protein (LBP), CD14, MD-2 for delivery to and activation of TLR4...
  52. Florea Lupu; Fiscal Year: 2014
    ..Aim 3 will determine whether combining complement blockade with immunological inhibition of CD14 or extracellular histones could provide superior/additional effects therapeutic effects on E...
  53. Jeffrey R Capadona; Fiscal Year: 2016
    ..The co-receptor cluster of differentiation 14 (CD14) has been shown to coordinate the binding and recognition of pathogens or damaged cells for at least four different ..
  54. Stanley H Appel; Fiscal Year: 2014
    ..Misfolded toxic proteins, such as SOD1 and TDP-43, added to microglia/motoneuron co-cultures activated the TLR/CD14 signaling pathway, resulting in microglial activation, NF?B and p38 activation, escalating release of pro-..
  55. SUBSTANCE P-MEDIATED CARDIOVASCULAR INFLAMMATION
    William Weglicki; Fiscal Year: 2009
    ..in the development of cardiac dysfunction during MgD, by using genetically manipulated murine models [NEP(-/-) and CD14 (-/-) mice]. 3...
  56. Interleukin-8 Induced Biology in Benign Prostatic Hyperplasia
    David R Rowley; Fiscal Year: 2013
    ..data suggests that reactive stroma may be recruited from circulating marrow- derived progenitor fibrocyte (CD14+) cells...
  57. Microbial Translocation and HIV-Related Endothelial Dysfunction
    MICHAEL PHILIP DUBE; Fiscal Year: 2010
    ..Using saved frozen specimens, levels of circulating LPS, soluble CD14, and bacterial 16S ribosomal DNA (16S rDNA) will be measured...
  58. Regulation of MD-2 function and expression
    Jerrold P Weiss; Fiscal Year: 2013
    ..features of E and ordered protein-E and protein-protein interactions involving the LPS-binding protein (LBP), CD14, MD-2, and Toll-like receptor (TLR) 4...
  59. Mechanisms of Frailty in HIV-1 Infection
    Kristine Mace Erlandson; Fiscal Year: 2012
    ..gut translocation in HIV-related frailty through plasma lipopolysaccharide (LPS) and soluble activation marker CD14 (sCD14) and 3) Use microarray analysis of human T-cell genes to identify potential gene expression patterns ..
  60. Hilary A Tindle; Fiscal Year: 2016
    ..Among HIV-infected people, high levels of microbial translocation (as measured by soluble CD14) and inflammation/altered coagulation (as measured by D- dimer) are each associated with an increased risk of death...
  61. Role of Sialidase in Pulmonary Host Defenses and Acute Lung Injury
    Alan Cross; Fiscal Year: 2010
    ..The molecular mechanism(s) by which desialylation promotes signaling through the TLR4/MD2/CD14 complex will be examined, as well as the ability of STs to downregulate this response...
  62. Genetic Regulation of Lung Transplant Outcomes
    Scott M Palmer; Fiscal Year: 2012
    ..in human lung transplant recipients which demonstrate that polymorphisms in the innate immune receptors TLR4 and CD14 significantly alter the risk for graft failure or rejection...
  63. CHARLES DEBEAUX MITCHELL; Fiscal Year: 2015
    ..by enhanced expression of the following markers: CD8+CD38+HLA-DR+, CD8+, CD38+, CD8+ HLA-DR+ T cells, and soluble CD14. Any specimen that has measurable 16SrDNA will also undergo qualitative 16SrRNA genomic amplification to determine ..
  64. Regulation of PAF Acetylhydrolase Expression by Oxidized Phospholipids
    SUZANNE BARBOUR; Fiscal Year: 2009
    ..We hypothesize that long chain, prostaglandin-like oxPL induce PAFAH by binding to the CD14/ TLR4 complex and the EP2 prostaglandin receptor on dendritic cells in the developing atherosclerotic lesion...
  65. TRAUMA & ORGAN FAILURE--ROLE OF LPS BINDING PROTEIN
    Stewart Wang; Fiscal Year: 2000
    ..During gram-negative sepsis, endotoxins (LPS) binds to CD14 receptors on mononuclear cells, causing release of inflammatory mediators which can cause tissue injury and organ ..