CD133

Summary

Gene Symbol: CD133
Description: prominin 1
Alias: AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4, prominin-1, antigen AC133, hProminin, hematopoietic stem cell antigen, prominin-like protein 1
Species: human

Top Publications

  1. ncbi Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133
    Sergey V Shmelkov
    Weill Medical College of Cornell University, Division of Hematology Oncology, 1300 York Ave, MED HEM ONC, C 606, New York, NY 10021, USA
    Blood 103:2055-61. 2004
  2. ncbi Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer
    Mareike Florek
    Medical Clinic and Polyclinic I, University Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Cell Tissue Res 319:15-26. 2005
  3. ncbi Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases
    Niven Mehra
    Department of Medical Oncology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Cancer Res 12:4859-66. 2006
  4. pmc Is CD133 a marker of metastatic colon cancer stem cells?
    Mark A Labarge
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Clin Invest 118:2021-4. 2008
  5. pmc CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers
    L M Smith
    Seattle Genetics Inc, 21823 30th Drive Southeast, Bothell, WA 98021, USA
    Br J Cancer 99:100-9. 2008
  6. ncbi CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity
    Shengyong Yin
    Department of General Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People s Republic of China
    Int J Cancer 120:1444-50. 2007
  7. pmc CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinoma
    Linni Fan
    State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    BMC Cancer 11:320. 2011
  8. pmc Aberrant expression of CD133 in non-small cell lung cancer and its relationship to vasculogenic mimicry
    Shiwu Wu
    Department of Pathology, the First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu 233000, Anhui Province, China
    BMC Cancer 12:535. 2012
  9. doi Clinicopathological significance and prognostic value of CD133 expression in triple-negative breast carcinoma
    Po Zhao
    Department of Pathology, Chinese People s Liberation Army General Hospital, Beijing, China
    Cancer Sci 102:1107-11. 2011
  10. doi Co-expression of stem cell genes CD133 and CD44 in colorectal cancers with early liver metastasis
    Xiaodong Huang
    Pharmacy College, Jilin University, Chuangchun, Jilin Province, China
    Surg Oncol 21:103-7. 2012

Research Grants

  1. CpG island methylation in glioblastoma cancer stem cells
    KRISTOPHER MOOREFIELD; Fiscal Year: 2007
  2. Role of Olig Genes in Human Gliomagenesis
    Santosh Kesari; Fiscal Year: 2011
  3. RNA-based Immunotherapy Targeting Antigens Unique to Brain Tumor Stem Cells
    John H Sampson; Fiscal Year: 2012
  4. Cellular Quiescence and Brain Tumor Stem Cells
    Cho Lea Tso; Fiscal Year: 2009
  5. Identifying mechanisms of liver stem cell proliferation and differentiation
    CARL BARTH ROUNTREE; Fiscal Year: 2010
  6. Xing Fan; Fiscal Year: 2015
  7. Characterization of CD44 in brain tumor stem cells
    Ichiro Nakano; Fiscal Year: 2010
  8. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
  9. Brain Tumor Stem Cell-targeted Gene Therapy
    JOHN OHLFEST; Fiscal Year: 2007
  10. MARIA BARTOLOMEO GRANT; Fiscal Year: 2016

Detail Information

Publications256 found, 100 shown here

  1. ncbi Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133
    Sergey V Shmelkov
    Weill Medical College of Cornell University, Division of Hematology Oncology, 1300 York Ave, MED HEM ONC, C 606, New York, NY 10021, USA
    Blood 103:2055-61. 2004
    b>AC133 is a member of a novel family of cell surface proteins with 5 transmembrane domains. The function of AC133 is unknown...
  2. ncbi Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer
    Mareike Florek
    Medical Clinic and Polyclinic I, University Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Cell Tissue Res 319:15-26. 2005
    ..This lack of detection of human prominin-1, as defined by its glycosylation-dependent AC133 epitope, is surprising given the expression of the murine ortholog in adult epithelia...
  3. ncbi Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases
    Niven Mehra
    Department of Medical Oncology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Cancer Res 12:4859-66. 2006
    We examined whether RNA expression of CD133, a surface molecule expressed on progenitors from hematopoietic and endothelial lineages, and CD146, a pan-endothelial marker, are increased in the blood of cancer patients and whether these ..
  4. pmc Is CD133 a marker of metastatic colon cancer stem cells?
    Mark A Labarge
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Clin Invest 118:2021-4. 2008
    ..Over the last decade, a large body of literature has implicated the protein CD133 as a marker of organ-specific adult stem cells and in some cancers as a bona fide CSC marker...
  5. pmc CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers
    L M Smith
    Seattle Genetics Inc, 21823 30th Drive Southeast, Bothell, WA 98021, USA
    Br J Cancer 99:100-9. 2008
    ..A murine anti-human CD133 antibody (AC133) conjugated to a potent cytotoxic drug, monomethyl auristatin F (MMAF), effectively inhibited the growth of Hep3B ..
  6. ncbi CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity
    Shengyong Yin
    Department of General Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People s Republic of China
    Int J Cancer 120:1444-50. 2007
    ..b>CD133 is a putative hematopoietic and neuronal stem-cell marker, which was also considered as a tumorigenic marker in ..
  7. pmc CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinoma
    Linni Fan
    State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    BMC Cancer 11:320. 2011
    b>CD133 is known to be a cancer stem cell (CSC) marker...
  8. pmc Aberrant expression of CD133 in non-small cell lung cancer and its relationship to vasculogenic mimicry
    Shiwu Wu
    Department of Pathology, the First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu 233000, Anhui Province, China
    BMC Cancer 12:535. 2012
    To investigate on expressions and clinical significances of CD133 protein and vasculogenic mimicry (VM) in primary non-small cell lung cancer (NSCLC).
  9. doi Clinicopathological significance and prognostic value of CD133 expression in triple-negative breast carcinoma
    Po Zhao
    Department of Pathology, Chinese People s Liberation Army General Hospital, Beijing, China
    Cancer Sci 102:1107-11. 2011
    Currently, CD133 is one of the best markers to characterize cancer stem cells and Her-1 is reported as an important marker for the prognosis of triple-negative breast cancer...
  10. doi Co-expression of stem cell genes CD133 and CD44 in colorectal cancers with early liver metastasis
    Xiaodong Huang
    Pharmacy College, Jilin University, Chuangchun, Jilin Province, China
    Surg Oncol 21:103-7. 2012
    To investigate the expression status and clinical implications of stem cell genes CD133 and CD44 in the colorectal cancers with early liver metastasis.
  11. ncbi A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning
    S Miraglia
    AmCell Corp, Sunnyvale, CA 94089, USA
    Blood 90:5013-21. 1997
    ..We have recently described the production of AC133, a monoclonal antibody (MoAb) that binds to a novel cell surface antigen present on a CD34(bright) subset of human ..
  12. pmc Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells
    Yuanyan Wei
    Key Laboratory of Glycoconjuates Research, Ministry of Public Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
    Proc Natl Acad Sci U S A 110:6829-34. 2013
    The biological significance of a known normal and cancer stem cell marker CD133 remains elusive...
  13. doi Stem cell marker prominin-1/AC133 is expressed in duct cells of the adult human pancreas
    Jessy Lardon
    Cell Differentiation Unit, Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Pancreas 36:e1-6. 2008
    ..Prominin-1, particularly its specific glycosylation-dependent AC133 epitope, is expressed on stem/progenitor cells of various human tissues and can be used to isolate them...
  14. pmc Prognostic role of CD133 expression in colorectal cancer: a meta-analysis
    Ke Wang
    Cancer Institute Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education Provincial Key Laboratory of Molecular Biology in Medical Sciences, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China
    BMC Cancer 12:573. 2012
    b>CD133 has been identified as a putative cancer stem cell marker in colorectal cancer (CRC). However, the clinical and prognostic significance of CD133 in CRC remains controversial.
  15. ncbi AC133, a novel marker for human hematopoietic stem and progenitor cells
    A H Yin
    AmCell Corp, Sunnyvale, CA 94089, USA
    Blood 90:5002-12. 1997
    b>AC133 is one of a new panel of murine hybridoma lines producing monoclonal IgG antibodies (mAbs) to a novel stem cell glycoprotein antigen with a molecular weight of 120 kD...
  16. pmc Autosomal recessive retinitis pigmentosa with early macular affectation caused by premature truncation in PROM1
    Jon Permanyer
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Invest Ophthalmol Vis Sci 51:2656-63. 2010
    ..To identify the genetic basis of a large consanguineous Spanish pedigree affected with autosomal recessive retinitis pigmentosa (arRP) with premature macular atrophy and myopia...
  17. doi Prognostic value of the stem cell markers CD133 and ABCG2 expression in esophageal squamous cell carcinoma
    D Hang
    Laboratory of Genetic, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China
    Dis Esophagus 25:638-44. 2012
    ..light of increasing evidence supporting cancer stem cells (CSCs) theory, the expression of two stem cell markers, CD133 and adenosine triphosphate-binding cassette superfamily G member 2 (ABCG2), in esophageal squamous cell carcinoma (..
  18. ncbi Demethylation of the CD133 gene is frequently detected in early gastric carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:1201-3. 2010
    ..reported that colorectal carcinoma is created and propagated by a small number of undifferentiated tumorigenic CD133(+) cells...
  19. pmc Increased expression of CD133 and reduced dystroglycan expression are strong predictors of poor outcome in colon cancer patients
    Claudio Coco
    Dipartimento di Scienze Chirurgiche, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Exp Clin Cancer Res 31:71. 2012
    Expression levels of CD133, a cancer stem cell marker, and of the α-subunit of the dystroglycan (α-DG) complex, have been previously reported to be altered in colorectal cancers.
  20. pmc Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
    Giulia Bertolini
    Molecular Cytogenetics Unit, Department of Experimental Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 106:16281-6. 2009
    ..b>CD133, a surface glycoprotein linked to organ-specific stem cells, was described as a marker of cancer-initiating cells ..
  21. doi Increased membrane shedding--indicated by an elevation of CD133-enriched membrane particles--into the CSF in partial epilepsy
    Hagen B Huttner
    Epilepsy Center, Department of Neurology, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Epilepsy Res 99:101-6. 2012
    ..in addition to soluble proteins also contains membrane particles that moreover carry the somatic stem cell marker CD133. The significance of CD133 as a potential marker of cellular proliferation, including neurogenesis, remains ..
  22. doi Expression profiling of CD133+ and CD133- epithelial cells from human prostate
    Christopher J Shepherd
    Prostate Stem Cell Laboratory, Institute of Cancer Research, Sutton, Surrey, UK
    Prostate 68:1007-24. 2008
    Recent evidence suggests that prostate stem cells in benign and tumor tissue express the cell surface marker CD133, but these cells have not been well characterized...
  23. ncbi Influence of oxygen tension on CD133 phenotype in human glioma cell cultures
    Nadine Platet
    INSERM, U836, Universite Joseph Fourier, CHU, Grenoble, F 38043, France
    Cancer Lett 258:286-90. 2007
    ..We demonstrate, using low-passaged human tumor cell cultures established from glioma, that a reduction in the oxygen level in these cell cultures dramatically increases the percentage of CD133 expressing cells.
  24. pmc Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling
    Luciola S Barcelos
    Bristol Heart Institute, University of Bristol, Upper Maudlin Street, Bristol, United Kingdom
    Circ Res 104:1095-102. 2009
    We evaluated the healing potential of human fetal aorta-derived CD133(+) progenitor cells and their conditioned medium (CD133(+) CCM) in a new model of ischemic diabetic ulcer...
  25. doi Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133+ primary colon cancer cells
    Y K Wang
    Cancer Institute, Zhejiang University School of Medicine, Hangzhou, China
    Carcinogenesis 31:1376-80. 2010
    ..However, the molecular mechanism of CSC involved in these events needs to be further elucidated. In this study, CD133(+) colon cancer cells were cultured, which showed CSC properties both in vitro and in vivo from metastatic tissue...
  26. ncbi Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys
    Costanza Sagrinati
    Interdepartmental Laboratory of Cellular and Molecular Nephrology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
    J Am Soc Nephrol 17:2443-56. 2006
    ..of parietal epithelial cells (PEC) in the Bowman's capsule exhibit coexpression of the stem cell markers CD24 and CD133 and of the stem cell-specific transcription factors Oct-4 and BmI-1, in the absence of lineage-specific markers...
  27. pmc The PROM1 mutation p.R373C causes an autosomal dominant bull's eye maculopathy associated with rod, rod-cone, and macular dystrophy
    Michel Michaelides
    UCL Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 51:4771-80. 2010
    ..To characterize in detail the phenotype of five unrelated families with autosomal dominant bull's eye maculopathy (BEM) due to the R373C mutation in the PROM1 gene...
  28. doi CD133(+) single cell-derived progenies of colorectal cancer cell line SW480 with different invasive and metastatic potential
    Guangqiu Li
    Department of Pathology, Southern Medical University, Guangzhou, People s Republic of China
    Clin Exp Metastasis 27:517-27. 2010
    ..b>CD133 (Prominin-1, Prom1) is the marker of human colorectal cancer (CRC) stem cells and probably a marker of metastatic ..
  29. doi Clinical significance of CD133 and hypoxia inducible factor-1α gene expression in rectal cancer after preoperative chemoradiotherapy
    S Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, Japan
    Clin Oncol (R Coll Radiol) 23:323-32. 2011
    ..Therefore, we investigated the correlation between the expression of CD133 and hypoxia inducible factor-1α (HIF-1α), and their association with clinical outcome.
  30. doi CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation
    Hiroshi Fukamachi
    Department of Molecular Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 102:1313-21. 2011
    b>CD133 is a universal marker of tissue stem/progenitor cells as well as cancer stem cells, but its physiological significance remains to be elucidated...
  31. ncbi Expression of CD133 correlates with differentiation of human colon cancer cells
    Hai liang Feng
    Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing, China
    Cancer Biol Ther 9:216-23. 2010
    b>CD133 has been identified as a cancer stem cell marker in colon and several other cancers, but its function is still unknown...
  32. doi Identification of Endothelin-1 and NR4A2 as CD133-regulated genes in colon cancer cells
    Maria Ausiliatrice Puglisi
    Institute of Internal Medicine, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Pathol 225:305-14. 2011
    ..b>CD133 antigen has been proposed as a CSC marker in colon cancer (CC)...
  33. pmc CD133 and CD44 are universally overexpressed in GIST and do not represent cancer stem cell markers
    Junwei Chen
    Department of Pathology, Memorial Sloan Kettering Cancer Center, NY, USA
    Genes Chromosomes Cancer 51:186-95. 2012
    ..study was aimed to determine whether expression of commonly used stem cell markers in other malignancies, that is, CD133 and CD44, might identify cells with characteristics of cancer stem/progenitor cells in human GIST...
  34. doi Protein cross-talk in CD133+ colon cancer cells indicates activation of the Wnt pathway and upregulation of SRp20 that is potentially involved in tumorigenicity
    Claudia Corbo
    CEINGE, Biotecnologie Avanzate Scarl, Naples, Italy
    Proteomics 12:2045-59. 2012
    ..Putative CSCs were separated from non-CSCs by flow cytometry using CD133 as stemness marker...
  35. doi In vivo investigation of CD133 as a putative marker of cancer stem cells in Hep-2 cell line
    Xu Dong Wei
    Department of Otolaryngology Head and Neck Surgery, Fudan University, Affiliated Eye, Ear, Nose, and Throat Hospital, Shanghai, China
    Head Neck 31:94-101. 2009
    ..Our in vitro experiment shown as CD133, a 5-transmembrane glycoprotein expressed in Hep-2 cell line...
  36. doi CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway
    Herve Sartelet
    Department of Pathology and Cytogenetics, CHU Sainte Justine, Université de Montreal Research Center, CHU Sainte Justine, Montreal, QC, Canada
    Histopathology 60:1144-55. 2012
    Neuroblastoma is a frequent childhood cancer with a heterogeneous prognosis. CD133 expression is an independent prognostic marker for a low survival rate in several cancers...
  37. doi Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors
    Sergio Rutella
    Department of Hematology and Department of Gynecology, Catholic University Medical School, USA
    Clin Cancer Res 15:4299-311. 2009
    ..The present study aimed to determine whether CD133 expression may identify cells with characteristics of cancer stem/progenitor cells in human endometrial tumors.
  38. pmc Expressions and clinical significances of CD133 protein and CD133 mRNA in primary lesion of gastric adenocacinoma
    Ji wei Yu
    Department of General Surgery, NO, 3 People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China
    J Exp Clin Cancer Res 29:141. 2010
    To study on expressions and clinical significances of CD133 protein and CD133 mRNA in primary lesion of gastric adenocarcinoma (GC).
  39. pmc Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma
    Johan Rebetz
    The Rausing Laboratory, Division of Neurosurgery, Lund University Hospital, Lund, Sweden
    PLoS ONE 3:e1936. 2008
    ....
  40. pmc Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines
    Marie Jaksch
    Tumor Development Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, California 92035, USA
    Cancer Res 68:7882-6. 2008
    ..Reactivity with an antibody (AC133) to a glycoslyated form of CD133 has been widely used for the enrichment of cells with tumor-initiating activity ..
  41. pmc CD133 is a marker of bioenergetic stress in human glioma
    Corinne E Griguer
    Department of Surgery, Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA
    PLoS ONE 3:e3655. 2008
    ..Recently, many studies have focused on isolation of brain cancer stem cells using CD133 expression...
  42. ncbi AC133-2, a novel isoform of human AC133 stem cell antigen
    Ying Yu
    Surgical Research Laboratory, Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:20711-6. 2002
    Human AC133 antigen, also called CD133, was recently identified as a hematopoietic stem cell marker. However, the molecular structure and function of this protein has remained unclear...
  43. ncbi Biology and plasticity of CD133+ hematopoietic stem cells
    Rupert Handgretinger
    Division of Stem Cell Transplantation, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Ann N Y Acad Sci 996:141-51. 2003
    AC133 (CD133) is a highly conserved antigen expressed on hematopoietic stem cells with unknown function...
  44. ncbi CD133, a novel marker for human prostatic epithelial stem cells
    Gavin D Richardson
    Prostate Research Group, Surgical Oncology, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    J Cell Sci 117:3539-45. 2004
    ..Human CD133 antigen, also known as AC133, was recently identified as a haematopoietic stem cell marker...
  45. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
    ..Purification experiments established that all CC-ICs were CD133+; the CD133- cells that comprised the majority of the tumour were unable to initiate tumour growth...
  46. ncbi Nomenclature of prominin-1 (CD133) splice variants - an update
    C A Fargeas
    Tissue Engineering Laboratories, BIOTEC, Technical University of Dresden, Dresden, Germany
    Tissue Antigens 69:602-6. 2007
    Prominin-1 (CD133), a pentaspan membrane glycoprotein that constitutes an important cell surface marker of various, either normal or cancerous, stem cell populations is widely used to isolate or characterize such cells in different ..
  47. ncbi Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence
    Edward H Lin
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 110:534-42. 2007
    b>CD133 is a specific surface marker for bone marrow-derived circulating endothelial progenitors, which are vital in postnatal physiologic and pathologic (eg, tumor) angiogenesis...
  48. ncbi Expression of CD133-1 and CD133-2 in ovarian cancer
    G Ferrandina
    Gynecologic Oncology Unit, Catholic University of the Sacred Heart, Rome, Italy
    Int J Gynecol Cancer 18:506-14. 2008
    ..Stem cells isolated from nervous system and prostate express CD133 antigen, which is widely used to isolate hematopoietic stem and progenitor cells...
  49. pmc CD133 expression is an independent prognostic marker for low survival in colorectal cancer
    D Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Str 36, 80337 München, Germany
    Br J Cancer 99:1285-9. 2008
    Colon cancer cells have previously been demonstrated to contain a subpopulation of CD133+ tumour cells that have the ability to initiate tumour growth and are thus referred to as colon cancer-initiating cells or colon cancer stem cells (..
  50. pmc Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors
    Joo Mi Yi
    Cancer Biology Division, Johns Hopkins Kimmel Cancer Center, USA
    Cancer Res 68:8094-103. 2008
    ..We report here an unusual promoter DNA methylation pattern for one such marker, the cell surface antigen CD133 (Prominin 1)...
  51. doi Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells
    T Baba
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27708, USA
    Oncogene 28:209-18. 2009
    ..As the cell surface marker CD133 identifies cancer-initiating cells in a number of other malignancies, we sought to determine the potential role of ..
  52. doi The first extracellular domain of the tumour stem cell marker CD133 contains an antigenic ganglioside-binding motif
    Nadira Taïeb
    CRN2M, CNRS UMR 6231, INRA USC 2027, Laboratoire des Interactions Moléculaires et Systèmes Membranaires, University of Aix Marseille 2 and Aix Marseille 3, Faculté des Sciences de St Jérôme, Marseille Cedex 20, France
    Cancer Lett 278:164-73. 2009
    b>Prominin 1/CD133 is a marker of transplantable cancer stem cells. We have generated anti-peptide antibodies against a N-terminal epitope of CD133 belonging to a ganglioside-binding domain...
  53. doi Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Ann Surg Oncol 16:3488-98. 2009
    ..We investigated the role of three stem cell markers (CD133, OCT4, and SOX2) in rectal cancer and evaluated the association between these gene levels and clinical outcome in ..
  54. doi Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer
    Qi Wang
    Department of Colorectal Surgery, Beijing Cancer Hospital and Institute, Beijing, China
    Histopathology 55:284-93. 2009
    The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues...
  55. doi CD133 expression predicts for non-response to chemotherapy in colorectal cancer
    Chee W Ong
    Department of Pathology, National University Health System and Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Mod Pathol 23:450-7. 2010
    ..In this study, immunohistochemistry for three candidate cancer stem cell markers (CD133, Oct-4 and Sox-2) and for six other postulated prognostic markers (CK7, CK20, Cox-2, Ki-67, p27 and p53) were ..
  56. pmc Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta
    Hanning You
    Department of Pediatrics and Pharmacology, Pennsylvania State University College of Medicine, Penn State Children s Hospital, Hershey, PA 17033, USA
    Hepatology 51:1635-44. 2010
    Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. CD133, a transmembrane glycoprotein, is an important cell surface marker for both stem cells and cancer stem cells in various tissues including ..
  57. doi Post-translational modulation of CD133 expression during sodium butyrate-induced differentiation of HT29 human colon cancer cells: implications for its detection
    A Sgambato
    Institute of General Pathology, Giovanni XXIII Cancer Research Center, Catholic University, Rome, Italy
    J Cell Physiol 224:234-41. 2010
    The CD133 molecule has been proposed as a surface marker of cancer stem cells in several human malignancies, including colon cancers. The function and the mechanisms regulating CD133 expression remain unknown...
  58. doi CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma
    Mitsuo Shimada
    Department of Surgery, Institute of Health Biosciences, The University of Tokushima, Kuramoto 3 18 15, Tokushima 770 8503, Japan
    J Gastroenterol 45:896-902. 2010
    b>CD133 is one of the most important cancer-initiating (stem) cell markers and was confirmed to be expressed in solid cancers such as colon cancer...
  59. pmc The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer
    Tarek M A Elsaba
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 5:e10714. 2010
    b>CD133 is a membrane molecule that has been, controversially, reported as a CSC marker in colorectal cancer (CRC). In this study, we sought to clarify the expression and role of CD133 in CRC...
  60. pmc Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer
    A Lugli
    Institute of Pathology, University of Basel, Basel, Switzerland
    Br J Cancer 103:382-90. 2010
    The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer.
  61. doi The combination of stem cell markers CD133 and ABCG2 predicts relapse in stage I non-small cell lung carcinomas
    Feng Li
    Respiratory Department, Sir Run Run Shaw Hospital, Affiliated with School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, China
    Med Oncol 28:1458-62. 2011
    The aim of the study was to investigate the expression of two cancer stem cell markers CD133 and ATP-binding cassette superfamily G member 2 (ABCG2) in non-small cell lung carcinomas (NSCLC) and evaluate their prognostic values for ..
  62. doi Overexpression of CD133 promotes the phosphorylation of Erk in U87MG human glioblastoma cells
    Lin Dong
    Department of Cell Biology, Peking University Health Science Center, 38 Xueyuan Road, Haidian, Beijing100191, China
    Neurosci Lett 484:210-4. 2010
    ..b>CD133 has been identified as an important cell surface marker to enrich the stem-like population in various human tumors...
  63. doi Prognostic impact of CD133 expression as a tumor-initiating cell marker in endometrial cancer
    Mitsuhiro Nakamura
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    Hum Pathol 41:1516-29. 2010
    ..The present study dissected the roles of CD133 as a tumor-initiating cell marker in endometrial cancer and investigated the prognostic impact of this marker ..
  64. pmc SDF-1α secreted by human CD133-derived multipotent stromal cells promotes neural progenitor cell survival through CXCR7
    Benjamin Bakondi
    Department of Medicine, Stem Cell Core, University of Vermont, Colchester, Vermont 05446, USA
    Stem Cells Dev 20:1021-9. 2011
    We recently reported that concentrated conditioned medium (CdM) from human CD133-derived bone marrow progenitor cells (CD133 CdM) was neuroprotective after stroke...
  65. doi CD133 mRNA expression and microsatellite instability in colorectal carcinoma
    Jung Wook Huh
    Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea
    J Surg Oncol 102:765-70. 2010
    The present study was performed to examine the CD133 expression in colorectal cancer and to analyze its relationship with microsatellite instability (MSI) and the clinicopathological factors, including patient survival.
  66. doi Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo
    Virginia Tirino
    Department of Experimental Medicine, Section of Histology and Embryology, 5 via L Armanni, Second University of Naples, 80138 Naples, Italy
    FASEB J 25:2022-30. 2011
    ..cytometric analyses for stemness and differentiation antigens, including CD29, CD34, CD44, CD90, CD117, and CD133, on 21 human primary sarcomas on the day of surgery...
  67. pmc Upregulated CD133 expression in tumorigenesis of colon cancer cells
    Zhi Li Yang
    Department of Surgery, Affiliated Sixth People s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
    World J Gastroenterol 17:932-7. 2011
    To analyze the upregulated CD133 expression in tumorigenesis of primary colon cancer cells.
  68. doi Clinicopathological significance and prognostic value of EphA3 and CD133 expression in colorectal carcinoma
    Hong Qing Xi
    Department of Pathology, Chinese People s Liberation Army General Hospital, Beijing, China
    J Clin Pathol 64:498-503. 2011
    To investigate clinicopathological significance and prognostic implications of EphA3, CD133 and Ki-67 expression in colorectal cancer.
  69. doi Prognostic impact of CD133 mRNA expression in 48 glioblastoma patients treated with concomitant radiochemotherapy: a prospective patient cohort at a single institution
    Philippe Metellus
    Service de Neurochirurgie, Hopital de la Timone, Marseille, France
    Ann Surg Oncol 18:2937-45. 2011
    ..The CD133 antigen has been described as a putative stem cell marker in malignant brain tumor that could identify such a ..
  70. doi Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells
    Okito Hashimoto
    Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathobiology 78:181-92. 2011
    ..Intratumoral hypoxia is known to lead to increased aggressiveness and distant metastasis. However, the interplay underlying these actions is still unknown...
  71. pmc Sequential expression of putative stem cell markers in gastric carcinogenesis
    T Wang
    Cancer Science Institute, National University Health System and Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Br J Cancer 105:658-65. 2011
    Gastric carcinogenesis has been well documented in the step-wise histopathological model, known as Correa pathway. Several biomarkers including CD44, Musashi-1 and CD133 have been reported as putative stem cell (PSC) markers.
  72. doi Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2
    Hajime Iida
    Department of Biochemistry, University of Occupational and Environmental Health, Fukuoka, Japan
    Int J Oncol 40:71-9. 2012
    b>CD133 has been recognized as a specific cell surface marker for cancer stem cells in various tumors, although its biological functions and transcriptional regulation remain unclear...
  73. doi CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling
    Kwan Ho Tang
    Department of Pathology, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hepatology 55:807-20. 2012
    ..a TIC population derived from hepatocellular carcinoma (HCC) that is characterized by membrane expression of CD133. Here, we describe a novel mechanism by which these cells mediate tumor growth and angiogenesis by systematic ..
  74. doi CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma
    Lian Shu Piao
    WHO Collaborating Center of Viral Hepatitis, The Catholic University of Korea, Seoul 137 701, Republic of Korea
    Cancer Lett 315:129-37. 2012
    b>CD133 is a cancer stem-cell (CSC) marker associated with radioresistance and chemoresistance in various cancers...
  75. pmc Immunohistochemical detection of CD133 is associated with tumor regression grade after chemoradiotherapy in rectal cancer
    Kumiko Hongo
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Med Oncol 29:2849-57. 2012
    b>CD133 has been identified as a putative cancer stem cell (CSC) marker in various cancers including colorectal cancer. The relation between CD133 expression and biological characteristics of colorectal cancer remains to be clarified...
  76. doi The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription
    Anthony B Mak
    Donnelley Centre and Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 72:1929-34. 2012
    ..To identify transcription factors that regulate CD133 expression, we conducted parallel large-scale RNA interference screens in Caco-2 cancer cells that endogenously ..
  77. doi Expressions of putative cancer stem cell markers ABCB1, ABCG2, and CD133 are correlated with the degree of differentiation of gastric cancer
    Yang Jiang
    Department of Pathology, Harbin Medical University, 157 Xuefu Road, Nangang District, Harbin 150081, Heilongjiang, People s Republic of China
    Gastric Cancer 15:440-50. 2012
    ..The present study was carried out to determine whether a quantitative relationship exists between the expressions of 3 cancer stem cell (CSC) markers and the degree of differentiation of gastric cancer...
  78. ncbi Expression of AC133, a novel hematopoietic precursor antigen, on acute myeloid leukemia cells
    P A Horn
    Blood 93:1435-7. 1999
  79. pmc A new locus for autosomal dominant stargardt-like disease maps to chromosome 4
    M Kniazeva
    Department of Molecular, Cellular, and Developmental Biology, Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA
    Am J Hum Genet 64:1394-9. 1999
    ..00, for marker D4S403. Analysis of extended haplotypes localized the disease gene to an approximately 12-cM interval between loci D4S1582 and D4S2397. Therefore, this kindred establishes a new dominant Stargardt-like locus, STGD4.
  80. ncbi A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration
    M A Maw
    Biochemistry Department, University of Otago, PO Box 56, Dunedin, New Zealand
    Hum Mol Genet 9:27-34. 2000
    ..One such candidate is the gene encoding human prominin (mouse)-like 1 (PROML1, previously known as AC133 antigen) which belongs to the prominin family of 5-transmembrane domain proteins...
  81. ncbi Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein
    D Corbeil
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden, D 01307, Germany
    Biochem Biophys Res Commun 285:939-44. 2001
    ....
  82. ncbi An autosomal dominant bull's-eye macular dystrophy (MCDR2) that maps to the short arm of chromosome 4
    Michel Michaelides
    Institute of Ophthalmology, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 44:1657-62. 2003
    ..To describe the phenotype of an autosomal dominant macular dystrophy and identify the chromosomal locus...
  83. ncbi Comparative genomics on PROM1 gene encoding stem cell marker CD133
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 19:967-70. 2007
    ..PROM1 gene encodes CD133 protein, which is a cell surface marker of hematopoietic stem cells, prostatic epithelial stem cells, pancreatic ..
  84. ncbi [Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma]
    Hui Zhong Zhang
    Department of Cardiothoracic Surgery, Second Affiliated Hospital of Sun Yat Sen University, Guangzhou 510120, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:696-9. 2007
    To investigate the expression of tumor stem cell marker CD133 and endothelin-converting enzymes (ECE) in non-small cell lung carcinoma (NSCLC) and their association with NSCLC lymphoid metastasis.
  85. ncbi Severe retinitis pigmentosa mapped to 4p15 and associated with a novel mutation in the PROM1 gene
    Qingjiong Zhang
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20982, USA
    Hum Genet 122:293-9. 2007
    ..The mutation was not detected in 192 chromosomes of unrelated control individuals of the same ethnicity and from the same region. This delineates the phenotypic characteristics of retinopathy caused by mutations in PROM1...
  86. ncbi The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease
    Hagen B Huttner
    Tissue Engineering Laboratories, Biotechnology Center BIOTEC, Technische Universitat Dresden, Tatzberg 47 51, 01307 Dresden, Germany
    Stem Cells 26:698-705. 2008
    ..Here, we show that human CSF contains specific membrane particles that carry prominin-1/CD133, a neural stem cell marker implicated in brain tumors, notably glioblastoma...
  87. doi Stem cell marker CD133 affects clinical outcome in glioma patients
    Felix Zeppernick
    Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, Germany
    Clin Cancer Res 14:123-9. 2008
    The CD133 antigen has been identified as a putative stem cell marker in normal and malignant brain tissues. In gliomas, it is used to enrich a subpopulation of highly tumorigenic cancer cells...
  88. doi CD133 expression and cancer stem cells predict prognosis in high-grade oligodendroglial tumors
    Dagmar Beier
    Laboratory of Neurooncology, Department of Neurology, University of Regensburg, Medical School, Regensburg, Germany
    Brain Pathol 18:370-7. 2008
    ..Tumors with favorable prognosis neither contained CSC nor did they show CD133 expression...
  89. doi Expression and clinical significance of stem cell marker CD133 in human neuroblastoma
    Qiang Song Tong
    Department of Pediatric Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    World J Pediatr 4:58-62. 2008
    Recent evidences indicate that CD133, a kind of transmembrane protein, can be used as a marker to isolate stem cells from tumors originating from neural crest...
  90. doi Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma
    Qin Shu
    Laboratory of Molecular Neuro Oncology, Texas Children s Cancer Center, Texas Children s Hospital, 6621 Fannin St, MC 3 3320, Houston, Texas 77030, USA
    Stem Cells 26:1414-24. 2008
    ..More importantly, the CD133(+) tumor cells, ranging from 0.2%-10...
  91. pmc The stem cell marker CD133 (Prominin-1) is expressed in various human glandular epithelia
    Jana Karbanova
    Department of Histology and Embryology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
    J Histochem Cytochem 56:977-93. 2008
    ..of prominin-1 in adult human epithelia might be explained, at least in part, by the specificity of the widely used AC133 antibody, which recognizes an epitope that seems dependent on glycosylation...
  92. pmc Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice
    Zhenglin Yang
    Department of Ophthalmology and Visual Science, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah, USA
    J Clin Invest 118:2908-16. 2008
    ..Here we show that an R373C missense mutation in the prominin 1 gene (PROM1) causes 3 forms of autosomal-dominant macular degeneration...
  93. doi Promoter hypomethylation regulates CD133 expression in human gliomas
    Kouichi Tabu
    Laboratory of Molecular and Cellular Pathology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    Cell Res 18:1037-46. 2008
    Brain tumor-initiating cells (BTICs) have been enriched using antibodies against the cell surface protein CD133; however, the biological relevance and the regulatory mechanism of CD133 expression in human gliomas are not yet understood...
  94. doi Immunohistochemical detection of CD133 expression in colorectal cancer: a clinicopathological study
    Motohiro Kojima
    Pathology Division, Research Center for Innovative Oncology, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Cancer Sci 99:1578-83. 2008
    b>CD133 has been reported to be a cancer-initiating cell marker in colorectal carcinoma...
  95. pmc The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma
    Germana Rappa
    Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama 36688, USA
    Stem Cells 26:3008-17. 2008
    b>CD133 (Prominin-1) is considered the most important cancer stem cell (CSC)-associated marker identified so far, with increased expression in the CSC fraction of a large variety of human malignancies, including melanoma...
  96. pmc The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cells
    Donald J Vander Griend
    Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Brady Urological Institute, and Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 68:9703-11. 2008
    ..When epithelial cell suspensions containing cells expressing the stem cell marker CD133+ are inoculated in vivo, regeneration of stratified human prostate glands requires inductive prostate stromal ..
  97. doi How powerful is CD133 as a cancer stem cell marker in brain tumors?
    Jin Xiang Cheng
    Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province 710032, PR China
    Cancer Treat Rev 35:403-8. 2009
    ..b>CD133, a stem cell marker, is now extensively used as a surface marker to identify and isolate brain tumor stem cells (..
  98. pmc Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB
    Chun Yan Li
    Biotherapy Center, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    J Transl Med 7:56. 2009
    ..To evaluate the overpopulation hypothesis of cancer stem cells the association of percentage of CD133+ tumor cells with clinicopathological parameters in colon cancer was investigated since CD133 is a putative cancer ..
  99. pmc CD133 antigen expression in ovarian cancer
    Gabriella Ferrandina
    Gynecologic Oncology Unit, Department of Oncology, Catholic University, Campobasso, Italy
    BMC Cancer 9:221. 2009
    ..In this context, CD133 antigen has proved to be a marker of tumor cells with stemness features in several human malignancies...
  100. doi The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Strasse 36, 80337 München, Germany
    J Pathol 219:427-34. 2009
    In colon cancer, CD133 has recently been used to enrich for a subset of tumour cells with tumour-initiating capabilities and was therefore suggested to mark colon cancer stem cells...
  101. doi Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer
    David Horst
    Pathologisches Institut, Ludwig Maximilians Universitat Munchen, Germany
    Cancer Invest 27:844-50. 2009
    b>CD133, CD44, and CD166 are cell surface markers that have recently been associated with colorectal cancer stem cells...

Research Grants78

  1. CpG island methylation in glioblastoma cancer stem cells
    KRISTOPHER MOOREFIELD; Fiscal Year: 2007
    ..A subpopulation of primary GBM cells (CD133+) is capable of initiating tumor formation in nude mice, and thus appear to contain cancer stem cells...
  2. Role of Olig Genes in Human Gliomagenesis
    Santosh Kesari; Fiscal Year: 2011
    A small population of CD133 (a stem cell marker) positive "tumor stem cells" has been recently shown to embody the tumorigenic phenotype of human glioblastomas...
  3. RNA-based Immunotherapy Targeting Antigens Unique to Brain Tumor Stem Cells
    John H Sampson; Fiscal Year: 2012
    ..These brain tumor stem cells (BTSC) can be segregated by the neural stem cell marker, CD133, and are widely believed to be the cells responsible for resistance to conventional therapies...
  4. Cellular Quiescence and Brain Tumor Stem Cells
    Cho Lea Tso; Fiscal Year: 2009
    ..We have established several tumorigenic CD133+ glioblastoma (GBM) stem cell lines, which are directly derived from patients'primary tumors that are ..
  5. Identifying mechanisms of liver stem cell proliferation and differentiation
    CARL BARTH ROUNTREE; Fiscal Year: 2010
    ..We have recently identified a population of CD133+ murine oval cells that demonstrates bi-lineage (i.e...
  6. Xing Fan; Fiscal Year: 2015
    ..Our recent data shows that Notch pathway inhibition by gamma-secretase inhibitors reduced CD133 expression and reduces glioblastoma neurosphere propagation both in vitro and in vivo...
  7. Characterization of CD44 in brain tumor stem cells
    Ichiro Nakano; Fiscal Year: 2010
    ..on our preliminary data, CD44 is selectively expressed by stem cells within brain tumor cells, in comparison to CD133, the only marker currently adopted to enrich for BTSC...
  8. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..Under the third aim, cell-specific populations of CD133+ endothelial progenitor cells (EPCs), hematopoietic stem cells, and mesenchymal stem cells will be seeded into ..
  9. Brain Tumor Stem Cell-targeted Gene Therapy
    JOHN OHLFEST; Fiscal Year: 2007
    ..a novel BTSC-targeted plasmid delivery vector by conjugating polyethylenimine (PEI) transfection reagent with anti-CD133 antibody because BTSCs express the CD133 receptor but their daughter cells do not...
  10. MARIA BARTOLOMEO GRANT; Fiscal Year: 2016
    ..Aim 3 will translate our mouse findings into hHPCs. We will express RPE65, in human CD133+, CD 34- , CD38- cells to differentiate these cells toward RPE cells and allow RPE regeneration in SCID mice ..
  11. p53, Rb and Ras Pathways in Neural Stem Cell Homeostasis and Transformation
    Monica Venere; Fiscal Year: 2009
    ..These cells are exclusively CD133+ and have the capacity for self-renewal as well as the ability to phenotypically recapitulate the primary tumor ..
  12. Testing the Cancer Stem Cell Hypothesis: Role of CD133+ Cells as Tumor Stem Cells
    Kyuson Yun; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): The goal of this project is to provide insight into the role of CD133+ tumor stem cells in tumor growth and recurrence in human and mouse brain tumors...
  13. Elizabeth J Shpall; Fiscal Year: 2016
    ..In the two clinical CB expansion trials conducted during the last RO1 funding period, CD133+ progenitors were isolated and cultured ex vivo in a liquid culture system targeting committed, or more primitive ..
  14. Hypoxia-Perfusion Bioreactor for Stem Cell Applications
    TODD A MCADAMS; Fiscal Year: 2010
    ..ability to expand hematopoietic stem cells (HSCs) without the requirement for previous selection (CD34+ or AC133+) for primitive stem cell populations...
  15. Khalid A Shah; Fiscal Year: 2014
    ..and study the effect of EGFR-NB on EGFR signaling and cell proliferation in a panel of primary glioma cells and CD133+ primary brain tumor cells in an ongoing collaboration with Settleman lab (MGH, Boston)...
  16. Jingfang Ju; Fiscal Year: 2014
    ..We further revealed that the expression of miR-140 was elevated in a small population of CD133+HICD44+HI colon cancer stem-like cells...
  17. Endothelial Progenitor Cells in Brain Arteriovenous Malformations
    Yongmei Chen; Fiscal Year: 2010
    ..EPCs will be identified using the stem cell marker CD133 and the endothelial cell marker KDR...
  18. Khalid A Shah; Fiscal Year: 2016
    ..the proposed studies, we will first create and characterize different GBM resection models using patient derived CD133+ GBMs based on 3 different phenotypes (invasive, semi-invasive and nodular)...
  19. Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic lik
    Russell S Taichman; Fiscal Year: 2013
    ..Adult human VSELs, are SSEA-4+/Oct-4+/CD133+/CXCR4+/Lin-/CD45-, express pluripotency markers (Oct-4 and Nanog) and are capable of differentiation into cells ..
  20. Keith A Webster; Fiscal Year: 2014
    ..We propose to profile miR expression in different CD34+ and CD133+ cell populations from CAD patients with and without type 2 diabetes and investigate the role of serum factors in ..
  21. Nanog-positive cancer stem cells in and liver oncogenesis by alcohol and HCV
    Keigo Machida; Fiscal Year: 2013
    ..Nanog immunostaining is co-localized with the cancer stem cell marker CD133 and CD49f in liver tumors of these mice...
  22. Target migratory nature of glioblastoma stem cells
    Cho Lea Tso; Fiscal Year: 2010
    ..Thus, the novel discovery of slow-cycling, radioresistant CD133+ GBM stem-like cells possessing the enhanced ability to repopulate tumors provides a new model to explain our ..
  23. Regulation of Glioma Cell Migration by RasGRP3
    Chaya Brodie; Fiscal Year: 2010
    ..and Arp3 in glioma cell migration in vivo using xenografts derived from U87 cells overexpressing RasGRP3 and CD133+ glioma stem cells in which RasGRP3 is silenced...
  24. Suniti Misra; Fiscal Year: 2014
    ..2) CD44v6 is a specific cancer stem cell marker than total CD44, and can be used in conjunction with CD166 or CD133 to isolate cancer stem cells...
  25. Gerold Bepler; Fiscal Year: 2015
    ..The third aim is to determine if aATC decreases the frequency of putative CD44hi/CD24lo, CD133+, ALDH1 positive breast cancer stem cells (CSC) in the tumor tissue at the time of surgery compared to that found ..
  26. Daniel J Brat; Fiscal Year: 2015
    ..They have thus far been identified by the expression of specific markers, such as CD133, Sox2 and nestin, yet molecular mechanisms responsible for stem-like behavior have not been clearly defined, nor ..
  27. Ningjun Li; Fiscal Year: 2014
    ..we found that the level of an important stem cell niche factor, fibroblast growth factor-2 (FGF2), the number of CD133 positive stem cells and their responses to high salt intake were significantly decreased in the renal medulla in ..
  28. Interfollicular epidermal stem cells in human and mouse skin
    DENISE LEA GAY; Fiscal Year: 2011
    ..We have discovered unique cells within human and mouse postnatal skin which co-express the stem cell marker CD133 and basal marker alpha6 integrin...
  29. Gabriele Bergers; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): We recently discovered a p75NTR+/CD133+ population of multipotent mesenchymal stem-cell-like cells (MPMSC) in pancreatic neuroendocrine tumors that exhibit high self-renewal capacity and ..
  30. Inflammation and Lung Carcinogenesis
    David M Jablons; Fiscal Year: 2012
    ..cells associated with human and mouse lung carcinogenesis and determine how these correlate with presence of CD133+ cells and activation of Wnt and Shh signaling cascades, 2) define functional significance of recruited immune ..
  31. Sharmila Shankar; Fiscal Year: 2016
    ..We have recently demonstrated that human CD133+CD44+CD24+ESA+ CSCs express Nanog, Notch-1 and Oct-4 and are highly tumorigenic in mice...
  32. Diverse roles of Notch signaling in glioblastoma
    Dimitris G Placantonakis; Fiscal Year: 2013
    ..that, under in vitro conditions that favor GSC self-renewal, Notch is activated in cells that do not express CD133, a well-established cell surface marker of GSCs...
  33. Autophagy in Brain Tumor
    Jin Ming Yang; Fiscal Year: 2013
    ..in integrated studies with the human glioma cell lines and primary tumor-base, clinically relevant (invasive and CD133+) orthotopic glioma xenograft models developed by our collaborators at Baylor College of Medicine (Aim 3)...
  34. Sheng He Huang; Fiscal Year: 2014
    ..marker)/CD146+(EC marker)/S100B+ (brain marker)] as well as endothelial progenitor cells (EPC)[UEA+/CD146+/CD133+(progenitor cell marker)]...
  35. Engineered HSV For Treatment of Malignant Glioma
    Richard J Whitley; Fiscal Year: 2013
    ..activated MEK (caMEK), IL12 and are re-targeted to unique cell surface receptors (IL13Ralpha2, uPAR, Grp78 or CD133) expressed specifically and at high abundance on glioma cells in situ;a wild-type HSV that is entirely re-targeted ..
  36. Microenvironmental regulation of glioblastoma radiosensitivity
    PHILIP TOFILON; Fiscal Year: 2011
    ..Towards this end, the proposed studies will focus on intracerebral xenografts grown from CD133+ GB tumor initiating cells (TICs)...
  37. Xiao Fan Wang; Fiscal Year: 2016
    ..have examined changes in the expression profiles of microRNAs associated with responses to hypoxic conditions by CD133+ glioma stem/tumor initiating cells (GSCs)...
  38. Mei Yu Hsu; Fiscal Year: 2014
    ..In the current project, we focus on defining the microenvironmental "niche", of CD133+/ABCB5+ MICs as a gateway to elucidate the complex cellular and molecular interplay that maintains the metabolic ..
  39. Charles S Cobbs; Fiscal Year: 2014
    ..Nature, 2008). Our recent preliminary data indicate HCMV infection preferentially occurs in the CD133+ stem-like pool of GBM cells in vivo, and induces genes that sustain the cancer stem cell phenotype...
  40. Ovarian Cancer Initiating Cells: Metabolic Characterization
    Susan Kay Murphy; Fiscal Year: 2012
    ..We previously reported that CD133+ cells exhibit characteristics of cancer initiating cells (CICs) including the ability to undergo asymmetric ..
  41. Mark D Johnson; Fiscal Year: 2014
    ..small molecule inhibition of this pathway using a Cdc2 kinase inhibitor decreases the migration and invasion of CD133+ glioma-derived stem-like cells in vitro and in the mouse brain...
  42. Targeting the Hedgehog pathway in glioma tumor-initiating cells
    MICHAEL KANE COOPER; Fiscal Year: 2013
    ..types, one that uniquely confers resistance to radiation and chemotherapy has been identified by the expression of CD133 (Bao et al., 2006a;Liu et al., 2006)...
  43. Monica T Hinds; Fiscal Year: 2014
    ..valve leaflet surface by conjugating oriented capture antibodies directed at cell surface markers (KDR, CD34, and CD133) to specifically capture EPCs. Capture will be evaluated both in vitro and ex vivo...
  44. Local Warming: Effects on Wound Infection and Healing
    JoAnne Whitney; Fiscal Year: 2007
    ..Percent of endothelial progenitor cells (EPC) CD133 positive, CD34 and VEGFR-2 co-expressing) 2. Percent of endothelial cells (CD31 positive) 3...
  45. Vascular Heterogeneity Determination by Marrow Progenit*
    Shahin Rafii; Fiscal Year: 2006
    ..We have shown that VEGF family of angiogenic factors promote recruitment of CD133+VEGFR2+ endothelial progenitor cells (EPCs) from BM to the angiogenic neo-vessels...
  46. The role of complement activation in glioma proliferation
    Michael Sughrue; Fiscal Year: 2009
    ..but not C5aR is expressed by glioma cell lines and primary cultures, 3) in primary GBM samples, cells expressing CD133+ (one of many markers for a brain tumor stem cell) co-express C3aR, and 4) in vitro depletion of complement from ..
  47. Virotherapy for Neuroblastoma Stem Cells
    TIMOTHY CRIPE; Fiscal Year: 2009
    ..Cells express the neural stem cell marker CD133, exhibit a calcium channel-dependent side population, form spheres in serum-free media (that exhibit properties ..
  48. Symposium on Emerging Cardiac Cellular Therapies
    Edward Snyder; Fiscal Year: 2005
    ..e., CD34+ or CD133 cells); myoblasts; autologous cardiac stem cells; adipose tissue stem cells; mesenchymal stem cells...
  49. Regulation of tumor angiogenesis by Id+ marrow precursor
    David Lyden; Fiscal Year: 2006
    ..We have identified circulating CEPs, AC133 (+) VEGFR2 (+), capable of being recruited from BM to tumor vasculature bed, accelerating angiogenesis...
  50. PRECLINICAL EVALUATION OF INTERMEDIATE ENDPOINTS
    Ming You; Fiscal Year: 2000
    ..used to measure the levels of expression of several genes such as VEGF, VEGFR, Tie 2, E-Selectin, Collagen IV, and AC133 etc, which are known to be upregulated during angiogenesis and play an essential role during various phases of ..
  51. Marrow-Derived Stem Cells for Coronary Artery Ischemia
    Mary Laughlin; Fiscal Year: 2007
    ..The key hypothesis underlying this work is that early AC133+ hemangioblasts, rather than mature endothelial cells, are the critical cells that home to sites of vascular ..
  52. UCB Derived Vascular Endothelial Precursor Cells
    VINCENT POMPILI; Fiscal Year: 2004
    ..in vitro cellular and gene array analyses in order to gain further understanding of EPC development from early AC133+ stem cells, as well as gene regulation of EPC differentiation...
  53. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  54. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  55. Cellular MRI in Glioma and Radiation Necrosis
    Ali Syed Arbab; Fiscal Year: 2010
    ..Early detection of recurrent or metastatic glioma as well as early differentiation of glioma from radiation necrosis will help clinician to tackle the devastating neurological disease. ..
  56. Differentiation of Glioma from Radiation Injury Using Cellular MRI
    Syed Ali; Fiscal Year: 2008
    ..This magnetic labeling technique will also help investigators to track the injected CTL in the body as well as in the targeted areas by magnetic resonance imaging (MRI). [unreadable] [unreadable] [unreadable]..
  57. 7th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2008
    ..In summary, the only hope for our patients is by focused and concerted efforts such as the 7th International Podocyte Conference which will ultimately enhance their overall care. [unreadable] [unreadable] [unreadable]..
  58. Epigenetic mechanism of HSC transdifferentiation in alcoholic liver fibrosis
    Hidekazu Tsukamoto; Fiscal Year: 2007
    ..Kazuo Ikeda, a developer of this system. This exploratory study will be first to disclose epigenetic regulation of HSC transdifferentiation in ALF. [unreadable] [unreadable] [unreadable]..
  59. CELL CYCLE CONTROL IN GLOMERULAR DISEASE
    Stuart Shankland; Fiscal Year: 2007
    ..The ultimate goal is to identify new targets for potential therapies in order to reduce the heavy burden of disease in patients with gIomerular disease. ..
  60. AGING, GENE EXPRESSION AND OXIDATIVE STRESS
    Evan Keller; Fiscal Year: 2002
    ....
  61. ETHANOL MEDIATED OSTEOPOROSIS AND INTERLEUKIN 6
    Evan Keller; Fiscal Year: 2002
    ....
  62. 5TH INTERNATIONAL PODOCYTE CONFERENCE
    Stuart Shankland; Fiscal Year: 2004
    ..3. To facilitate cross-talk between clinicians and scientists with the ultimate goal of improving prognosis, treatment and care of patients with glomerular disease. ..
  63. Development of Androgen Independent Prostate Cancer
    Susan Kasper; Fiscal Year: 2007
    ..abstract_text> ..
  64. A Mouse model of TGFbeta1 and ras oncogene interactions
    Adam B Glick; Fiscal Year: 2010
    ....
  65. Phenotypic Plasticity in Human Neuroblastoma
    Robert Ross; Fiscal Year: 2008
    ..abstract_text> ..
  66. A Novel Autotransplant Protocol for CML
    Marcos de Lima; Fiscal Year: 2005
    ..abstract_text> ..
  67. VEGF and bone remodeling in skeletal metastases
    Evan Keller; Fiscal Year: 2005
    ..In this aim, we will test which VEGF isoform contributes to CaP cells' osteoblastic activity. We will also evaluate if VEGF induces this activity through MAPK. ..
  68. Immuno Biosensor for Real-Time Factor V Leiden Diagnosis
    KYUNG KANG; Fiscal Year: 2005
    ..Protocols developed for the Protein C biosensor will be used to detect FVN and FVL on two individual fiber optic sensors and a prototype of dual sensor will be developed. ..
  69. CARDIAC VALVE CALCIFICATION
    Emile Mohler; Fiscal Year: 2003
    ..2. To investigate mechanisms of valve calcification using a cell culture model of calcification. 3. To examine therapeutic strategies to inhibit valve calcification with a bisphosphonate in cell culture. ..
  70. GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
    Fredika Robertson; Fiscal Year: 2001
    ..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
  71. CHOC Human Embryonic Stem Cell Culture Training Course
    Philip Schwartz; Fiscal Year: 2008
    ..The courses are held annually in the Spring at the National Human Neural Stem Cell Resource of the Neuroscience Laboratories at the Children's Hospital of Orange County Research Institute. [unreadable] [unreadable] [unreadable]..
  72. 6th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2006
    ..Moreover, this is an exciting era in podocytes biology given the large body of literature that has been published in the past 2-5 years. [unreadable] [unreadable] [unreadable]..
  73. Developmental Biology of the Normal Mouse Prostate
    Susan Kasper; Fiscal Year: 2006
    ..Specific Aim III. To determine the function of these proteins in prostate tumorigenesis using the transgenic mouse model. ..
  74. MECHANISMS OF PODOCYTE INJURY
    Stuart Shankland; Fiscal Year: 2005
    ..Taken together, the overall goal is to show novel mechanisms underlying podo injury, so that ultimately, specific therapeutic strategies can be developed to reduce podo injury in the development of glomerular sclerosis. ..
  75. MYOCARDIAL PLASTICITY OF HUMAN FAT-DERIVED STEM CELLS
    Adam Katz; Fiscal Year: 2004
    ..This specific aim will determine whether intramyocardial injection of hADCs can reduce LV remodeling and improve cardiac function in a murine model of chronic myocardial infarction. ..
  76. MOLECULAR ANALYSIS OF MYOTONIC DYSTROPHY
    SATYAKAM BHAGWATI; Fiscal Year: 2002
    ..This approach is designed to explore the function of these CTG/CUG repeat binding proteins and their possible role in the pathogenesis of DM. ..