CD13

Summary

Gene Symbol: CD13
Description: alanyl aminopeptidase, membrane
Alias: APN, CD13, GP150, LAP1, P150, PEPN, aminopeptidase N, AP-M, AP-N, alanyl (membrane) aminopeptidase, aminopeptidase M, hAPN, membrane alanyl aminopeptidase, microsomal aminopeptidase, myeloid plasma membrane glycoprotein CD13
Species: human

Top Publications

  1. pmc Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
    R Pasqualini
    The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 60:722-7. 2000
  2. ncbi CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells
    Nenad Petrovic
    Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 278:49358-68. 2003
  3. ncbi Aminopeptidase N (CD13) functionally interacts with FcgammaRs in human monocytes
    Paola Mina-Osorio
    Department of Immunology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico
    J Leukoc Biol 77:1008-17. 2005
  4. ncbi CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells
    Yu Wen Chang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Int J Cancer 116:243-52. 2005
  5. ncbi Clinical significance of aminopeptidase N in non-small cell lung cancer
    Takahiro Tokuhara
    Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
    Clin Cancer Res 12:3971-8. 2006
  6. ncbi The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways
    Takao Miki
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    J Biol Chem 282:12341-52. 2007
  7. pmc CD13/APN regulates endothelial invasion and filopodia formation
    Nenad Petrovic
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Blood 110:142-50. 2007
  8. ncbi Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3
    Eunju Yang
    Chemical Genomics Laboratory, Department of Biotechnology, College of Engineering, Yonsei University, 134 Shinchon dong, Seodaemun gu, Seoul 120 749, Republic of Korea
    Biochem Biophys Res Commun 363:336-41. 2007
  9. pmc The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing
    Alan H M Wong
    Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 287:36804-13. 2012
  10. ncbi Enhancement of sensitivity by bestatin of acute promyelocytic leukemia NB4 cells to all-trans retinoic acid
    Takeo Hirano
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
    Leuk Res 26:1097-103. 2002

Research Grants

  1. JEAN L HANNAN; Fiscal Year: 2014
  2. Roles of two aminopeptidases in peptide catabolism in the malaria parasite
    Michael Klemba; Fiscal Year: 2012
  3. Sarjeet S Gill; Fiscal Year: 2016
  4. Biomarkers for Acute Pyelonephrititis in Children
    Nader Shaikh; Fiscal Year: 2011
  5. Novel Compounds to Inactivate Oncogenic Fusion Proteins
    Jeffrey A Toretsky; Fiscal Year: 2013
  6. George I Henderson; Fiscal Year: 2016
  7. Paul D Kaufman; Fiscal Year: 2014
  8. Astrocyte Control of Toxin-Mediated Neuron Death: Role of the Gamma-Glutamyl Path
    George I Henderson; Fiscal Year: 2010
  9. Jamie L Renbarger; Fiscal Year: 2016
  10. THOMAS EUGENE LLOYD; Fiscal Year: 2016

Detail Information

Publications588 found, 100 shown here

  1. pmc Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
    R Pasqualini
    The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 60:722-7. 2000
    ..We show here that the receptor for the NGR peptides in tumor vasculature is aminopeptidase N (APN; also called CD13)...
  2. ncbi CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells
    Nenad Petrovic
    Department of Physiology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 278:49358-68. 2003
    CD13/aminopeptidase N (CD13/APN) is a potent regulator of angiogenesis both in vitro and in vivo and transcription of CD13/APN in endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway...
  3. ncbi Aminopeptidase N (CD13) functionally interacts with FcgammaRs in human monocytes
    Paola Mina-Osorio
    Department of Immunology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico
    J Leukoc Biol 77:1008-17. 2005
    b>Aminopeptidase N (E.C. 3.4.11.2) is a membrane-bound metalloproteinase expressed in many tissues...
  4. ncbi CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells
    Yu Wen Chang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Int J Cancer 116:243-52. 2005
    ..We now report that CD13 (aminopeptidase N) can associate with TAL6 and can enhance cancer cell migration...
  5. ncbi Clinical significance of aminopeptidase N in non-small cell lung cancer
    Takahiro Tokuhara
    Department of Thoracic Surgery, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan
    Clin Cancer Res 12:3971-8. 2006
    ..A monoclonal antibody MH8-11, which we established, recognizes a glycoprotein that is identical to aminopeptidase N (APN/CD13)...
  6. ncbi The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways
    Takao Miki
    Department of Molecular Oncology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    J Biol Chem 282:12341-52. 2007
    ..Subsequently, we found that RECK interacts with CD13/aminopeptidase N. Further, we found that RECK inhibits the proteolytic activity of CD13 in a cholesterol perturbation-..
  7. pmc CD13/APN regulates endothelial invasion and filopodia formation
    Nenad Petrovic
    Department of Cell Biology, Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030 3501, USA
    Blood 110:142-50. 2007
    CD13/aminopeptidase N is a transmembrane peptidase that is induced in the vasculature of solid tumors and is a potent angiogenic regulator...
  8. ncbi Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3
    Eunju Yang
    Chemical Genomics Laboratory, Department of Biotechnology, College of Engineering, Yonsei University, 134 Shinchon dong, Seodaemun gu, Seoul 120 749, Republic of Korea
    Biochem Biophys Res Commun 363:336-41. 2007
    b>Aminopeptidase N/CD13 is an endothelial cell surface ectoenzyme involved in one of the initial steps of angiogenesis. However, little is known how APN induces angiogenesis in endothelial cells...
  9. pmc The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing
    Alan H M Wong
    Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 287:36804-13. 2012
    Human aminopeptidase N (hAPN/hCD13) is a dimeric membrane protein and a member of the M1 family of zinc metallopeptidases...
  10. ncbi Enhancement of sensitivity by bestatin of acute promyelocytic leukemia NB4 cells to all-trans retinoic acid
    Takeo Hirano
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan
    Leuk Res 26:1097-103. 2002
    ..We found that bestatin, an inhibitor of CD13/aminopeptidase N, enhanced the sensitivity of APL NB4 cells to ATRA at concentrations of 0.1-1000ng/ml...
  11. ncbi Synergistic action of DPIV and APN in the regulation of T cell function
    Uwe Lendeckel
    Institute of Experimental Internal Medicine, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Adv Exp Med Biol 524:123-31. 2003
    ..have been observed in response to inhibition of DPIV, which is strongly suggestive of a functional synergism of APN and DPIV...
  12. pmc CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells
    D Fontijn
    Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Br J Cancer 94:1627-36. 2006
    CD13/Aminopeptidase N (CD13) is known to play an important role in tumour cell invasion. We examined whether basic fibroblast growth factor (bFGF) is involved in the regulation of CD13 expression in human melanoma cells...
  13. pmc Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells
    Mikio Terauchi
    Department of Obstetrics and Gynecology, Nagoya University, Graduate School of Medicine, Tsuruma cho 65, Showa Ku, Nagoya 466 8550, Japan
    BMC Cancer 7:140. 2007
    b>Aminopeptidase N (APN/CD13), a 150-kDa metalloprotease, is a multifunctional cell surface aminopeptidase with ubiquitous expression...
  14. doi Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC
    Christian Mawrin
    Department of Neuropathology, Friedrich Schiller University, Jena, Germany
    Brain Pathol 20:200-10. 2010
    ..In this study, we examined the expression and function of the membrane alanyl-aminopeptidase [mAAP, aminopeptidase N (APN), CD13, EC3.4.11...
  15. doi Promoter methylation of aminopeptidase N/CD13 in malignant melanoma
    Jens Wulfänger
    Institute of Medical Immunology, Martin Luther University Halle Wittenberg, 06112 Halle, Saale, Germany
    Carcinogenesis 33:781-90. 2012
    b>Aminopeptidase N (APN)/CD13 as ubiquitously expressed membrane peptidase exerts important functions in diverse cellular processes, such as proliferation, migration and differentiation...
  16. ncbi The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis
    Shripad V Bhagwat
    Departments of Pathology, and Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
    Blood 101:1818-26. 2003
    ..The CD13/aminopeptidase N (CD13/APN) metalloprotease is an important regulator of angiogenesis where its expression on activated blood ..
  17. ncbi Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells
    L H Shapiro
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee
    J Biol Chem 266:11999-2007. 1991
    b>Aminopeptidase N is a membrane-bound metalloprotease expressed on the surface of normal and malignant human myeloid cells, fibroblasts, hepatocytes, and the epithelial cells that form brush borders of the small intestine and kidney...
  18. ncbi Activities of aminopeptidases in a rat saline model of volume hypertension
    I Prieto
    Unit of Physiology, University of Jaen, Spain
    Horm Metab Res 30:246-8. 1998
    ..saline model of arterial hypertension, aminopeptidase A activity (glutamyl- and aspartyl-aminopeptidase), aminopeptidase M activity (alanyl-aminopeptidase), aminopeptidase B activity (arginyl-aminopeptidase), pyroglutamyl-..
  19. ncbi Effects of low molecular weight peptides and divalent cations on degradation and binding of angiotensin II
    S Nomura
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan
    Horm Metab Res 22:444-8. 1990
    ..inhibitors for aminopeptidases A and M, and since Ca2+ and Co2+ are the activators for aminopeptidase A and aminopeptidase M, respectively, it is conceivable that the enzymes regulate the levels of A-II and, therefore, that they may ..
  20. ncbi Extracellular cysteines define ectopeptidase (APN, CD13) expression and function
    Beate Firla
    Institute of Immunology, Otto von Guericke University of Magdeburg, Magdeburg, Germany
    Free Radic Biol Med 32:584-95. 2002
    Alanyl aminopeptidase (APN) is a surface-bound metallopeptidase that processes the N-terminals of biologically active peptides such as enkephalins, angiotensins, neurokinins, and cytokines...
  21. ncbi Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13)--a novel approach for the treatment of inflammatory bowel disease
    Ute Bank
    IMTM GmbH, Leipziger Str 44, 39120 Magdeburg, Germany
    Int Immunopharmacol 6:1925-34. 2006
    The ectopeptidases Dipeptidylpeptidase IV and Alanyl-Aminopeptidase N, strongly expressed by both, activated and regulatory T cells were shown to co-operate in T cell regulation...
  22. ncbi Induction by cortisol of aminopeptidases production from the human placenta in tissue culture
    Y Yasuda
    Department of Obstetrics and Gynaecology, Nagoya University School of Medicine, Japan
    Horm Metab Res 24:110-4. 1992
    Human placental aminopeptidase M and A and post-proline endopeptidase are known to act as degrading enzymes of bioactive peptides such as angiotensin II, oxytocin and endogenous opioids...
  23. ncbi Adaptation of intestinal enzymes to seasonal and dietary changes in a hibernator: the European hamster (Cricetus cricetus)
    M Galluser
    , INSERM U61, Strasbourg, France
    J Comp Physiol B 158:143-9. 1988
    ..carbohydrates) exhibited a rise in disaccharidase activities (sucrase, isomaltase, lactase) but no changes in aminopeptidase N activity...
  24. ncbi Localization and orientation of subunit delta of spinach chloroplast ATP-synthase within the CF0 CF1 complex. 2. Identification of C-terminal residues of delta, exposed on the thylakoid membrane
    R J Berzborn
    , , , Bundesrepublik Deutschland
    Z Naturforsch C 44:480-6. 1989
    ..e. within the CF0 CF1 complex on the membrane, is not susceptible to digestion by aminopeptidase M and trypsin, but is shortened by about 1 kDa by carboxypeptidase Y and digested at residues Glu173 and Glu179 ..
  25. pmc Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I
    D B Tresnan
    Department of Microbiology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Virol 70:8669-74. 1996
    ..I, human respiratory coronavirus HCV-229E and porcine transmissible gastroenteritis virus (TGEV), use aminopeptidase N (APN) as their cellular receptors...
  26. ncbi [Expression of differentiation antigens on bone marrow myeloid cells of the patients with myelodysplastic syndromes and its clinical significances]
    Li Juan Li
    Department of Hematology and Oncology, General Hospital, Tianjin Medical University, Tianjin 300052, China
    Zhonghua Yi Xue Za Zhi 90:672-7. 2010
    ..To detect the abnormal differentiation of bone marrow myeloid cells in myelodysplastic syndromes (MDS) and its correlation with the prognosis of MDS patients...
  27. ncbi Liquid chromatographic study of the enzymatic degradation of endomorphins, with identification by electrospray ionization mass spectrometry
    A Peter
    Department of Inorganic and Analytical Chemistry, Attila Jozsef University, Szeged, Hungary
    J Chromatogr A 846:39-48. 1999
    ..3), were synthetized, and the levels of their resistance against carboxypeptidase A, carboxypeptidase Y, aminopeptidase M and proteinase A were determined...
  28. ncbi [Protective effects of adiponectin on myocardial ischemia-reperfusion injury in rats]
    Jun Wang
    Department of Cardiology, Yijishan Hospital, Wannan Medical College, Wuhu 241000, China
    Zhonghua Xin Xue Guan Bing Za Zhi 38:252-8. 2010
    ..To investigate the protective effects of adiponectin on myocardial ischemia-reperfusion injury and the potential mechanisms in rats...
  29. ncbi Characterization of Caenorhabditis elegans exonuclease-3 and evidence that a Mg2+-dependent variant exhibits a distinct mode of action on damaged DNA
    Andrea Shatilla
    University of Montreal, Maisonneuve Rosemont Hospital, Guy Bernier Research Centre, 5415 de l Assomption, Montreal, Quebec, Canada, H1T 2M4
    Biochemistry 44:12835-48. 2005
    The Caenorhabditis elegans genes, exo-3 and apn-1, encode the proteins EXO-3 and APN-1, belonging to the exo III and endo IV families of apurinic/apyrimidinic (AP) endonucleases/3'-diesterases, respectively...
  30. ncbi Molecular analysis of the coronavirus-receptor function of aminopeptidase N
    A F Kolb
    Institute of Virology and Immunology, University of Wurzburg, Germany
    Adv Exp Med Biol 440:61-7. 1998
    b>Aminopeptidase N (APN) is a major cell surface for coronaviruses of the serogroup I...
  31. pmc Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin
    Ivan Arenas
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos 62250, Mexico
    J Biol Chem 285:12497-503. 2010
    ..Two Manduca sexta glycosylphosphatidylinositol-anchored proteins, aminopeptidase (APN) and alkaline phosphatase (ALP), have been shown to bind Cry1Ab, although their role in toxicity remains to be ..
  32. ncbi Expression of CD13/aminopeptidase N and CD10/neutral endopeptidase on cultured human keratinocytes
    Jelka Gabrilovac
    Ruder Boskovic Institute, Division of Molecular Medicine, Bijenicka c 54, HR 10000 Zagreb, Croatia
    Immunol Lett 91:39-47. 2004
    ..In this study, we examined expression of two membrane-bound peptidases: aminopeptidase N (APN; EC 3.4.11.2; CD13) and neutral endopeptidase (NEP; EC 3.4.24...
  33. ncbi Minimally differentiated acute myeloid leukemia: a morphologic, cytochemical and ultrastructural study
    S S Alurkar
    Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India
    Tumori 78:185-9. 1992
    ..Further investigations revealed CD13 and CD33 positivity in 4 of 6 patients...
  34. pmc Bacillus thuringiensis Cry1Ca-resistant Spodoptera exigua lacks expression of one of four Aminopeptidase N genes
    Salvador Herrero
    Business Unit Bioscience, Plant Research International B V, Wageningen University and Research Center, The Netherlands
    BMC Genomics 6:96. 2005
    ..Aminopeptidases N (APNs) from several insect species have been shown to be putative receptors for these toxins. Here we report the cloning and expression analysis of four APN cDNAs from Spodoptera exigua.
  35. pmc A novel aminopeptidase in the fat body of the moth Achaea janata as a receptor for Bacillus thuringiensis Cry toxins and its comparison with midgut aminopeptidase
    Madhusudhan Budatha
    School of Life Sciences, University of Hyderabad, Hyderabad 500046, India
    Biochem J 405:287-97. 2007
    ..crystal proteins bind to cell-surface receptors which represent a family of aminopeptidases [APN (aminopeptidase N)] present on the brush border membrane of insect midgut cells of susceptible insects leading to pore ..
  36. ncbi Prevention of collagen crosslinking increases form-deprivation myopia in tree shrew
    N A McBrien
    Department of Physiological Optics, School of Optometry, University of Alabama at Birmingham 35294
    Exp Eye Res 59:475-86. 1994
    ..development, tree shrews were treated with agents that block collagen crosslinking [beta-aminoproprionitrile (beta-APN), or D-penicillamine (DPA)] and underwent monocular deprivation (MD) of form vision by eyelid closure to induce ..
  37. ncbi Lymphocyte 5'-nucleotidase and aminopeptidase N activity in patients on maintenance hemodialysis treated with human recombinant erythropoietin and 1-alpha-D3
    Vladisav Stefanovic
    Institute of Nephrology and Hemodialysis, Faculty of Medicine, Nis, Serbia
    Ren Fail 27:283-8. 2005
    ..human recombinant erythropoietin (rHu-EPO) and 1-alpha-D3 treatments on lymphocyte immunomodulatory enzymes, aminopeptidase N (APN), and 5'-nucleotidase activity in patients on HD were investigated in hemodialysis patients before and ..
  38. ncbi [Analysis of immunophenotype and leukemia associated immunophenotype in 610 patients with acute myeloid leukemia]
    Yan Rong Liu
    Peking University, Institute of Hematology, People s Hospital, Beijing, China
    Zhonghua Xue Ye Xue Za Zhi 28:731-6. 2007
    ..To analyze the immunophenotype and leukemia associated immunophenotype (LAIP) of leukemia cells from patients with acute myeloid leukemia (AML) in minimal residual disease (MRD) detection...
  39. doi Seasonal variation of peptidase activities in the reproductive tract of Crotalus durissus terrificus
    Camila Eduardo Marinho
    Laboratory of Pharmacology, Instituto Butantan, Av Vital Brasil, Sao Paulo, Brazil
    Gen Comp Endocrinol 160:84-92. 2009
    Seasonal quantitative patterns of acid (APA), basic (APB), puromycin-sensitive (APN-PS) and puromycin-insensitive neutral (APN-PI), cystyl (CAP), dipeptidyl IV (DPPIV), type-1 pyroglutamyl (PAP-I) and prolyl-imino (PIP) aminopeptidases ..
  40. doi Side population cells in the human decidua of early pregnancy exhibit stem/progenitor cell-like characteristics
    Chun Guo
    Department of Reproductive Endocrinology, West China Second University Hospital, Sichuan University, Chengdu 610041, PR China
    Reprod Biomed Online 21:783-93. 2010
    ..Decidual SP cells were negative for the mature decidual cell marker CD13 and prolactin and negative for CD34 and CD45 expression...
  41. ncbi Simultaneous high-performance capillary electrophoretic determination of reduced and oxidized glutathione in red blood cells in the femtomole range
    G Piccoli
    Istituto di Chimica Biologica Giorgio Fornaini, , Italy
    J Chromatogr A 676:239-46. 1994
    ..oxidized (GSSG) glutathione in mammalian red blood cells using a Supelco-bonded hydrophilic phase capillary CElect-P150. The extraction procedure of GSH and GSSG from erythrocytes using Microcon-10 membranes is very simple and allows a ..
  42. doi Neural damage associated with atopic diathesis: a nationwide survey in Japan
    N Isobe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Neurology 73:790-7. 2009
    ..the spectrum of neural damage associated with atopy, we conducted a cross-sectional nationwide survey of AM and atopy-related peripheral neuritis (APN), including Churg-Strauss syndrome (CSS), in individuals with atopic diathesis.
  43. pmc The Analgesic Activity of Bestatin as a Potent APN Inhibitor
    Mei Rong Jia
    School of Pharmacy, Shandong University Jinan, Shandong, China
    Front Neurosci 4:50. 2010
    ..was primarily marketed in 1987 in Japan as an anticancer drug and servers as the only marketed inhibitor of Aminopeptidase N (APN/CD13) to cure leukemia to date; (3) a pan-hematopoietic stimulator and restorator; Bestatin promotes ..
  44. ncbi Interaction of the human autoantigen p150 with splicing snRNPs
    B J Blencowe
    European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Sci 105:685-97. 1993
    ..specifically immunoprecipitates U4/U6 snRNP from HeLa cell extracts through recognition of a 150 kDa autoantigen (p150) (Okano and Medsger, Journal of Immunology, 146, 535-542, 1991)...
  45. pmc Recognition of lactoferrin and aminopeptidase M-modified lactoferrin by the liver: involvement of proteoglycans and the remnant receptor
    G J Ziere
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, University of Leiden, Sylvius Laboratory, The Netherlands
    Biochem J 313:289-95. 1996
    1. Lactoferrin and aminopeptidase M-modified lactoferrin (APM-lactoferrin; which lacks its 14 N-terminal amino acids) inhibit the liver uptake of lipoprotein remnant...
  46. ncbi Domain III exchanges of Bacillus thuringiensis CryIA toxins affect binding to different gypsy moth midgut receptors
    M K Lee
    Department of Biochemistry, Ohio State University, Columbus 43210, USA
    Biochem Biophys Res Commun 216:306-12. 1995
    ..This is the first direct evidence that domain III is involved in receptor binding and the first to demonstrate that domain III substitutions direct the binding of these toxins to different gypsy moth midgut receptors...
  47. ncbi Postnatal ontogeny of kinetics of porcine jejunal brush border membrane-bound alkaline phosphatase, aminopeptidase N and sucrase activities
    Ming Z Fan
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Comp Biochem Physiol A Mol Integr Physiol 132:599-607. 2002
    ..enzyme activity (V(max)) and enzyme affinity (K(m)) of jejunal mucosal membrane-bound alkaline phosphatase, aminopeptidase N and sucrase using a porcine model which may more closely resemble the human intestine...
  48. pmc Biochemical characterization of the native tissue form of type X collagen from embryonic chick sternal cartilage and identification of a chymotrypsin-sensitive site within its triple-helical domain
    A M Reginato
    Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    Biochem J 273:333-8. 1991
    ..lathyritic chick-embryo sterna and from organ cultures incubated in the presence of beta-aminopropionitrile (beta APN)...
  49. ncbi Development of a prototype personal digital assistant-decision support system for the management of adult obesity
    Nam Ju Lee
    Columbia University School of Nursing, 617 W 168th Street, New York, NY 10032, USA
    Int J Med Inform 76:S281-92. 2007
    ..The purpose of this study was to develop a prototype personal digital assistant-decision support system (PDA-DSS) based on a clinical practice guideline (CPG) for the management of obesity...
  50. ncbi Stage-specific modulation of neprilysin and aminopeptidase N in the limbic system during kindling progression
    Patricia de Gortari
    Div Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico D F, Mexico
    J Mol Neurosci 33:252-61. 2007
    b>Aminopeptidase N (APN) and neprilysin (NEP) inactivate neuropeptides released into the brain extracellular fluid...
  51. ncbi Flow cytometric measurement of RNA synthesis based on bromouridine labelling and combined with measurement of DNA content or cell surface antigen
    P O Jensen
    Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark
    Acta Oncol 32:521-4. 1993
    ..Using a new method for flow cytometric dual parameter analysis of BrUrd incorporation and a cell surface antigen, spontaneous RNA synthesis in HL-60 and K-562 cells was measured simultaneous with CD13 expression.
  52. ncbi Temporal association of the N- and O-linked glycosylation events and their implication in the polarized sorting of intestinal brush border sucrase-isomaltase, aminopeptidase N, and dipeptidyl peptidase IV
    H Y Naim
    Department of Physiological Chemistry, School of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    J Biol Chem 274:17961-7. 1999
    ..O-Glycosylation of pro-sucrase-isomaltase (pro-SI), aminopeptidase N (ApN), and dipeptidyl peptidase IV (DPPIV) is drastically reduced when processing of the mannose-rich N-..
  53. ncbi Vascular amine oxidase activities during synergistic vasculotoxicity
    M B Trent
    Department of Pathology, University of Texas Medical Branch, Galveston 77555 0605
    Toxicology 89:67-77. 1994
    Allylamine (AA) and beta-aminopropionitrile (beta APN) are well known vascular toxins with a demonstrated synergistic toxic effect, i.e. given together they cause extensive smooth muscle cell necrosis of the aortic media...
  54. ncbi [Adipokines and highly active antiretroviral therapy related lipodystrophy: clinical study of 52 cases]
    Mei mei Tao
    Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Yi Xue Za Zhi 89:867-71. 2009
    ..difference thereof between the HIV-lipodystrophy (LD) and non-HIV-LD groups, and to compare the plasma levels of adiponectin (APN) and leptin (LEP) and their relationship to metabolic disturbance and fat redistribution in these 2 groups.
  55. doi In vivo priming and ex vivo activation of equine neutrophils in black walnut extract-induced equine laminitis is not attenuated by systemic lidocaine administration
    John P Loftus
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Vet Immunol Immunopathol 138:60-9. 2010
    ..neutrophils were stimulated in vitro with LPS or recombinant equine IL-8 (reqIL-8) and surface expression of CD13 and CD18 was ascertained by immunofluorescent staining...
  56. ncbi Comparative evaluation of the combined osteolathyritic effects of two nitrile combinations on xenopus embryos
    D A Dawson
    Department of Biology Toxicology, Ashland University, 401 College Avenue, Ashland, OH 44805, USA
    Toxicology 147:193-207. 2000
    Two nitrile combinations, beta-aminopropionitrile (beta APN) with aminoacetonitrile (AAN) and betaAPN with beta APN (as a sham combination), were evaluated using the frog embryo mixture toxicity assay to determine their combined ..
  57. ncbi Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat
    Kumar Kotlo
    Department of Medicine, University of Illinois at Chicago, 840 S Wood St, Chicago, IL 60612
    Hypertension 49:467-72. 2007
    We have reported that aminopeptidase N/CD13, which metabolizes angiotensin III to angiotensin IV, exhibits greater renal tubular expression in the Dahl salt-resistant (SR/Jr) rat than its salt-sensitive (SS/Jr) counterpart...
  58. pmc Effects of mental illness and aging in two thalamic nuclei
    William Byne
    Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    Schizophr Res 106:172-81. 2008
    ..associated reduction of neuronal and oligodendrocyte number in the anterior principal thalamic nucleus (APN) in a cohort of severely impaired elderly subjects with schizophrenia (SZ) relative to age matched nonpsychiatric ..
  59. ncbi [Relationship of adipocyte fatty acid-binding protein to adiponectin ratio with femoral intima-media thickness and endothelium-dependent vasodilation in patients with newly-diagnosed type 2 diabetes mellitus]
    Yang Xiao
    Department of Endocrinology, Second Xiangya Hospital, Diabetes Center, Institute of Metabolism and Endocrinology, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 90:231-5. 2010
    To explore the relationship between plasma adipocyte fatty acid-binding protein (A-FABP), adiponectin (APN) levels and A-FABP/APN ratio with femoral intima-media thickness (FA-IMT) and endothelium-dependent vasodilation in patients with ..
  60. ncbi [Screening and identification of CD13-binding peptides with phage display peptide library]
    Yong Zhang
    Department of Thoracic Surgery, First Affiliated Hospital of Xi an Jiaotong University College of Medicine, Xi an 710061, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:827-30. 2010
    To screen and identify the peptides that specifically bind to CD13 on monocytes.
  61. pmc Characterization and overexpression of the Lactococcus lactis pepN gene and localization of its product, aminopeptidase N
    I J van Alen-Boerrigter
    Department of Biophysical Chemistry, Netherlands Institute for Dairy Research, Ede
    Appl Environ Microbiol 57:2555-61. 1991
    ..coli was obtained by using the T7 system. The overproduction of the 95-kDa aminopeptidase N could be visualized on sodium dodecyl sulfate-polyacrylamide gels and immunoblots...
  62. ncbi CD13/aminopeptidase N, a novel chemoattractant for T lymphocytes in pulmonary sarcoidosis
    K Tani
    Third Department of Internal Medicine, School of Medicine, Tokushima University, Tokushima, Japan
    Am J Respir Crit Care Med 161:1636-42. 2000
    CD13/aminopeptidase N (E.C.3.4.11.2) is an ectoenzyme located in the outer membrane of a variety of cells...
  63. pmc Pre- and post-translational negative effect of beta-adrenoceptor agonists on adiponectin secretion: in vitro and in vivo studies
    Marie Laure Delporte
    Unit of Endocrinology and Metabolism, University of Louvain, Faculty of Medicine, UCL 5530 Avenue Hippocrate, 55, B 1200 Brussels, Belgium
    Biochem J 367:677-85. 2002
    The adipose-derived hormone, adiponectin (ApN), has a role in fuel homoeostasis, insulin action and atherosclerosis. Regulation of ApN by catecholamines has scarcely been investigated...
  64. ncbi Binding and internalization of NGR-peptide-targeted liposomal doxorubicin (TVT-DOX) in CD13-expressing cells and its antitumor effects
    Seema V Garde
    Ambrilia Biopharma Inc, Chemin Du Golf, Verdun, Quebec, Canada
    Anticancer Drugs 18:1189-200. 2007
    ..The NGR peptide on the surface of liposomal doxorubicin (DOX) targets an aminopeptidase N (CD13) isoform, specific to the tumor neovasculature, making it a promising strategy...
  65. doi Adenosine deaminase that acts on RNA 1 p150 in alveolar macrophage is involved in LPS-induced lung injury
    Yumei Wu
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi an, PR China
    Shock 31:410-15. 2009
    ..Here, we report that up-regulation of inducible ADAR1 p150 isoform in macrophages stimulated with LPS and in AMs harvested from an ALI rat model...
  66. ncbi Local adiponectin treatment reduces atherosclerotic plaque size in rabbits
    Chang Jiang Li
    The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, No 107, Wenhua Xi Road, Jinan, Shandong 250012, People s Republic of China
    J Endocrinol 193:137-45. 2007
    ..on the development of atherosclerosis in rabbits mainly using adenovirus expressing adiponectin gene (Ad-APN) and intravascular ultrasonography...
  67. ncbi Effects of bestatin on intrauterine growth of rat fetuses
    M Furuhashi
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan
    Horm Metab Res 21:366-8. 1989
    Pregnant Wistar rats were injected with bestatin, a specific inhibitor of aminopeptidase M. Placental aminopeptidase M activity was inhibited by injection of bestatin, and fetal body weight was statistically lower than that in the saline-..
  68. ncbi Molecular basis for a severe case of leukocyte adhesion deficiency
    A L Corbi
    Unidad de Biologia Molecular, Hospital de la Princesa, Madrid, Spain
    Eur J Immunol 22:1877-81. 1992
    The leukocyte integrins LFA-1, Mac-1 and p150,95 (CD11a/CD18, CD11b/CD18, CD11c/CD18) mediate crucial leukocyte adhesive functions in immune and inflammatory reactions...
  69. pmc Hodgkin's cells express a novel pattern of adhesion molecules
    P A Ellis
    Department of Oncology, Christchurch Hospital, New Zealand
    Clin Exp Immunol 90:117-23. 1992
    ..The HC were shown to express the integrin beta 1 subfamily molecules, LFA-1 (CD11a) and p150,95 (CD11c) in high density but lacked CR3 (CD11b)...
  70. ncbi Villin, intestinal brush border hydrolases and keratin polypeptides in intestinal metaplasia and gastric cancer; an immunohistologic study emphasizing the different degrees of intestinal and gastric differentiation in signet ring cell carcinomas
    M Osborn
    Max Planck Institute for Biophysical Chemistry, Goettingen, Federal Republic of Germany
    Virchows Arch A Pathol Anat Histopathol 413:303-12. 1988
    Gastric carcinomas have been assayed for the presence of villin and for the small intestinal hydrolases aminopeptidase N and sucrase isomaltase. These proteins seem not to be present in normal stomach epithelium...
  71. ncbi Biochemical and functional characterization of MCS-2 antigen (CD13) on myeloid leukemic cells and polymorphonuclear leukocytes
    K Sakai
    Second Department of Internal Medicine, Kumamoto University Medical School, Japan
    Cancer Res 47:5572-6. 1987
    ..These findings suggested that MCS-2 mAb reacted with identical molecules, which were recognized by other mAbs belonging to CD13. Furthermore, modulation of MCS-2 antigen was observed by MCS-2 mAb itself.
  72. ncbi Nuclear assembly
    T M Gant
    Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Cell Dev Biol 13:669-95. 1997
    ..There are four identified proteins localized to the inner nuclear membrane: the lamina-associated proteins LAP1 and LAP2, emerin, and the lamin B receptor (LBR)...
  73. ncbi Characterization of 'adult-type' mast cells derived from human bone marrow CD34(+) cells cultured in the presence of stem cell factor and interleukin-6. Interleukin-4 is not required for constitutive expression of CD54, Fc epsilon RI alpha and chymase, an
    Y Shimizu
    Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    Clin Exp Allergy 32:872-80. 2002
    ..In vitro-derived human mast cells exhibit different properties, depending in part on the source of progenitor cells. Most investigations have used fetal liver, cord blood or peripheral blood. Few have used adult bone marrow...
  74. ncbi p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs
    Po Yan Cheung
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 279:45308-11. 2004
    ..b>p150(Glued) dynactin, a key component of the cytoplasmic dynein-dynactin motor complex, was found to specifically ..
  75. ncbi Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation
    Andrea Shatilla
    University of Montreal, Maisonneuve Rosemont Hospital, Guy Bernier Research Centre, 5415 de l Assomption, Montreal, Que, Canada H1T 2M4
    DNA Repair (Amst) 4:655-70. 2005
    ..We isolated two genes, apn-1 and exo-3, encoding proteins that have not been previously characterized...
  76. ncbi Expression of aminopeptidase N/CD13 in human ovarian cancers
    P Surowiak
    Institute of Pathology, Charite Campus Mitte, Berlin, Germany
    Int J Gynecol Cancer 16:1783-8. 2006
    b>Aminopeptidase N/CD13 (EC 3.4.11.2) is suggested to play a role in cancer cells invasion, and its activity can be inhibited using specific inhibitors. CD13 inhibitors evoke apoptosis of CD13-positive cancer cells...
  77. doi Digestive and metabolic flexibility allows female degus to cope with lactation costs
    Daniel E Naya
    Center for Advanced Studies in Ecology and Biodiversity and Departamento de Ecologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago CP 6513677, Chile
    Physiol Biochem Zool 81:186-94. 2008
    ..Our study reveals a complex interplay among energy acquisition, storage, and expenditure processes that ultimately determine an organism's fitness...
  78. pmc Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin
    Erica S Chevalier-Larsen
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    Hum Mol Genet 17:1946-55. 2008
    ..A mutation in p150(Glued), a component of the cytoplasmic dynein/dynactin microtubule motor complex, results in the human ..
  79. doi Leptin up-regulates the lactogenic effect of prolactin in the bovine mammary gland in vitro
    Y Feuermann
    Institute of Animal Science, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel
    J Dairy Sci 91:4183-9. 2008
    ..manner, and synergized to elevate the expression of amino acid metabolism via a 90% increase in aminopeptidase N expression...
  80. doi Phenotypic characterization of distinct human bone marrow-derived MSC subsets
    Hans Jorg Buhring
    University Clinic of Tubingen, Department of Internal Medicine II, Division of Hematology, Immunology, Oncology, and Rheumatology, Tubingen, Germany
    Ann N Y Acad Sci 1176:124-34. 2009
    ..Most of the tested antigens, including CD13, CD15, CD73, CD140b, CD144, CD146, and CD164, are expressed at similar levels in both primary BM populations...
  81. doi Acute myeloid leukemia with t(16;21)(q24;q22) and eosinophilia: case report and review of the literature
    Il Joong Park
    Department of Laboratory Medicine, Ajou University School of Medicine, San 5 Wonchun Dong, Yeongtong Gu, Suwon 443 721, Republic of Korea
    Cancer Genet Cytogenet 196:105-8. 2010
    ..Flow cytometric analysis revealed the expression of CD13, CD14, CD19, CD33, CD34, and HLA-DR by the leukemic blasts...
  82. doi Targeting aminopeptidase N (APN/CD13) with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells
    Shu Xiang Cui
    Shandong Medical Biotechnology Centre, Jinan 250062, China
    Cancer Lett 292:153-62. 2010
    b>Aminopeptidase N (APN/CD13) is an essential peptidase involved in the process of tumor growth, metastasis and angiogenesis. Inhibition of APN/CD13 may be an effective strategy for cancer treatment...
  83. pmc A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons
    Kerstin E Braunstein
    Department of Neurology, University of Ulm, Ulm, Germany
    Hum Mol Genet 19:4385-98. 2010
    ..This pathogenic role has been largely postulated from the existence of mutations in the dynactin subunit p150(Glued)...
  84. doi Onboarding advanced practice nurses: development of an orientation program in a cardiac center
    Karen Goldschmidt
    College of Nursing and Health Professions, Drexel University, Philadelphia, Pennsylvania, USA
    J Nurs Adm 41:36-40. 2011
    The advanced practice nurse (APN) is critical to continuity of patient care, particularly in an innovative and research-intensive environment...
  85. doi PETIR-001, a dual inhibitor of dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN), ameliorates experimental autoimmune encephalomyelitis in SJL/J mice
    Dirk Reinhold
    Institute of Molecular and Clinical Immunology, Otto von Guericke University Magdeburg, D 39120 Magdeburg, Germany
    Biol Chem 392:233-7. 2011
    Cellular dipeptidyl peptidase IV (DP IV, CD26) and amino-peptidase N (APN, CD13) play regulatory roles in T cell activation and represent potential targets for treatment of inflammatory disorders...
  86. pmc Host-viral effects of chromatin assembly factor 1 interaction with HCMV IE2
    Sung Bau Lee
    Genomics Research Center, Academia Sinica, Taipei 115
    Cell Res 21:1230-47. 2011
    Chromatin assembly factor 1 (CAF1) consisting of p150, p60 and p48 is known to assemble histones onto newly synthesized DNA and thus maintain the chromatin structure...
  87. doi Cell-cycle distribution of different cell compartments in normal versus reactive bone marrow: a frame of reference for the study of dysplastic hematopoiesis
    Sergio Matarraz
    Servicio de Citometría and Departamento de Medicina, Centro de Investigacion del Cancer, Instituto de Biología Celular y Molecular del Cáncer, CSIC USAL, Universidad de Salamanca, Salamanca, Spain
    Cytometry B Clin Cytom 80:354-61. 2011
    ..The only differences observed between normal and reactive BM were restricted to the more mature (CD13(hi) /CD11b(+) ) bands/neutrophils and to monocytic cells, which showed an increased PI (0.9% ± 0.8% vs. 0.6% ± 0...
  88. doi Topical application of aminopeptidase N-neutralizing antibody accelerates wound closure
    Amy Lai
    Burn and Wound Healing Research Laboratory, ICORD, the Blusson Spinal Cord Centre, Department of Surgery, University of British Columbia, 818 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada
    Mol Cell Biochem 372:95-100. 2013
    ..recent identification as a receptor responsible for stratifin-mediated matrix turnover in dermal fibroblasts, aminopeptidase N has been implicated in the regulation of epidermal-dermal communication and expression of key matrix ..
  89. pmc Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1
    Kristina M Okonski
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA
    J Virol 87:756-66. 2013
    ..Complementation of ADAR1(kd) cells by expression of either p150 WT isoform or the p150 Zα (Y177A) Z-DNA-binding mutant of ADAR1 restored suppression of host responses, including ..
  90. doi Study of 23 advanced-practice nurses suggest that their ability to facilitate evidence-based practice among frontline nurses is influenced by their personal attributes, relationships with stakeholders, responsibility and workload and organisational contex
    Mary van Soeren
    Canadian Health Care Innovations, Guelph, Ontario, Canada
    Evid Based Nurs 16:60-1. 2013
    ..Nursing and APN workload were factors limiting adoption of EBPs...
  91. doi CD13 expression is an independent adverse prognostic factor in adults with Philadelphia chromosome negative B cell acute lymphoblastic leukemia
    Kenneth J Craddock
    Department of Hematology and Pathology, University Health Network, Toronto, ON, Canada
    Leuk Res 37:759-64. 2013
    ..In addition to age, WBC and cytogenetic findings, CD13 positivity was an independent poor prognostic indicator for overall survival (OS, p=0...
  92. ncbi Effects of electroacupuncture and Chinese kidney-nourishing medicine on polycystic ovary syndrome in obese patients
    Liqing Yu
    Department of Acupuncture and Moxibustion, Shanghai Tianshan Hospital of Traditional Chinese Medicine, Shanghai 200051, China
    J Tradit Chin Med 33:287-93. 2013
    To explore the effect of electroacupuncture and Chinese kidney-nourishing medicine on insulin (INS), adiponectin (APN), leptin (LEP), and glucolipid metabolism of obese patients with polycystic ovary syndrome (PCOS).
  93. doi iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas
    Ting Kang
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, PR China
    Biomaterials 35:4319-32. 2014
    ..formulation is expected to achieve specific deep penetration in the tumor tissue by initially binding to aminopeptidase N, with iNGR proteolytically cleaved to CRNGR, and then bind with neuropilin-1 to mediate deep penetration in ..
  94. pmc Adiponectin deficiency exacerbates age-related hearing impairment
    T Tanigawa
    Department of Otolaryngology, Aichi Medical University, Aichi, Japan
    Cell Death Dis 5:e1189. 2014
    ..Adiponectin (APN) exerts protective effects against obesity-related conditions including endothelial dysfunction and atherosclerosis...
  95. pmc Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm
    Melissa Howard
    Center for Targeted Therapeutics and Translational Nanomedicine, Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States
    ACS Nano 8:4100-32. 2014
    ..Several endothelial surface markers including peptidases (e.g., ACE, APP, and APN) and adhesion molecules (e.g., ICAM-1 and PECAM) have been identified as key targets...
  96. pmc Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches
    Emily A Snavely
    Department of Molecular Genetics and Microbiology, Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC, USA
    Pathog Dis 71:336-51. 2014
    ..at least two host protein targets, vimentin filaments and the nuclear envelope protein lamin-associated protein-1 (LAP1), occurs rapidly after the loss of the inclusion membrane integrity, but before loss of plasma membrane ..
  97. doi The effect of recombinant adeno-associated virus-adiponectin (rAAV2/1-Acrp30) on glycolipid dysmetabolism and liver morphology in diabetic rats
    Wen Long
    Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China Electronic address
    Gen Comp Endocrinol 206:1-7. 2014
    ..Although APN expression increased in the liver tissue, serum levels were not significantly increased...
  98. pmc Increased Hs-CRP/adiponectin ratio is associated with increase carotid intima-media thickness
    Huocheng Liao
    Internal Medicine Cardiovascular Department, Dongying People s Hospital of Shandong Province, NO, 137, Nanyi Road, Dongying, Shangdong Province, China
    Lipids Health Dis 13:120. 2014
    High sensitivity C-reactive protein (Hs-CRP) and adiponectin (APN) are two critical cytokines and exert inverse effects on atherosclerosis initiation and progression...
  99. doi Proteome analysis of Lactobacillus helveticus H9 during growth in skim milk
    Y F Chen
    Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Huhhot, P R China, 010018 Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, P R China, 214122
    J Dairy Sci 97:7413-25. 2014
    ..Interestingly, the proteolytic system-related proteins aminopeptidase N (PepN), aminopeptidase E (PepE), endopeptidase O2 (PepO2), and oligopeptide transport system permease protein ..
  100. pmc Comparison of surface markers between human and rabbit mesenchymal stem cells
    Tao Chen Lee
    Department of Neurosurgery, Chiayi Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Chiayi, Taiwan
    PLoS ONE 9:e111390. 2014
    ..The phenotype of these cells was studied using flow cytometry antibodies for 25 rabbit surface markers, namely, CD13, CD14, CD29, CD31, CD34, CD44, CD45, CD49d, CD49f, CD51, CD54, CD59, CD71, CD73, CD90, CD105, CD106, CD133, CD166, ..
  101. doi Advanced practice nursing, health care teams, and perceptions of team effectiveness
    Kelley Kilpatrick
    Université du Québec en Outaouais Dr Kilpatrick, Saint Jérôme McGill University Drs Lavoie Tremblay and Ritchie McGill University Health Centre Dr Ritchie Université de Montréal Dr Lamothe, Montreal, Quebec, Canada
    J Trauma Nurs 21:291-9. 2014
    ..the results of an extensive review of the organizational and health care literature of advanced practice nursing (APN) roles, health care teams, and perceptions of team effectiveness. Teams have a long history in health care...

Research Grants63

  1. JEAN L HANNAN; Fiscal Year: 2014
    ..Intervention group mothers will receive a minimum of 10 two-way advanced practice nurse (APN) cell phone calls plus text messaging on post hospital discharge days 3, 7, 14, 21, months 1-6;be able to contact ..
  2. Roles of two aminopeptidases in peptide catabolism in the malaria parasite
    Michael Klemba; Fiscal Year: 2012
    ..We have identified two vacuolar aminopeptidases, P. falciparum aminopeptidase N (PfA-M1) and aminopeptidase P (PfAPP), and propose that hemoglobin is extensively degraded to amino acids in ..
  3. Sarjeet S Gill; Fiscal Year: 2016
    ..This implies both APN and ALP of mosquitoes could act as primary rather than as secondary receptors as in moths, suggesting a possible ..
  4. Biomarkers for Acute Pyelonephrititis in Children
    Nader Shaikh; Fiscal Year: 2011
    ..In others, bacteria successfully ascend from the bladder to the kidney causing acute pyelonephritis (APN). APN is one of the principal causes of acquired renal scarring in children...
  5. Novel Compounds to Inactivate Oncogenic Fusion Proteins
    Jeffrey A Toretsky; Fiscal Year: 2013
    ..We identified RNA Helicase A (RHA, p150), a DEAD/H family member that modulates gene expression, as a critical partner of EWS-FLI1...
  6. George I Henderson; Fiscal Year: 2016
    ..and second by enhancing regulation of a GSH scavenging system (;-glutamyl transpeptidase (3GT), and aminopeptidase N. Experiments will define mechanisms of ethanol effects on transcriptional and posttranscriptional events ..
  7. Paul D Kaufman; Fiscal Year: 2014
    ..Via mass spectrometry, we discovered multiple nucleolar proteins associated with the human CAF-1-p150 subunit...
  8. Astrocyte Control of Toxin-Mediated Neuron Death: Role of the Gamma-Glutamyl Path
    George I Henderson; Fiscal Year: 2010
    ..resistance protein(s) (Mrp), and two plasma membrane ectopeptidases, ?-glutamyl transpeptidase (GGT) and aminopeptidase N (ApN). Specific Aim 3: Aim 3 will use an in vivo model to extend the in vitro findings to the intact animal...
  9. Jamie L Renbarger; Fiscal Year: 2016
    ..CXCL9), elafin, interleukin-2-receptor-alpha, soluble B-cell-activating factor (sBAFF), and soluble CD13] diagnoses chronic GVHD...
  10. THOMAS EUGENE LLOYD; Fiscal Year: 2016
    ..Our Preliminary Results suggest that these mutations differentially affect p150 interactions with MTs and p150 function at synapses...
  11. The Role of LOX/LOXL Family Members in Abdominal Aortic Aneurysms (AAA)
    EBONY WASHINGTON; Fiscal Year: 2010
    ..Follow up infusion of B-APN, an irreversible inhibitor of LOX, caused AAA in 100% of the mice, supporting a role for LOX in AAA pathogenesis...
  12. Flora Sam; Fiscal Year: 2016
    ..a link between aldosterone and obesity with evidence that adipocytes, in addition to secreting adiponectin (APN), may release secreted factors that stimulate aldosterone release independent of angiotensin-II...
  13. HEME OXYGENASE REGULATION OF EICOSANOID BIOSYNTHESIS
    Nader G Abraham; Fiscal Year: 2013
    ..Therefore, we assembled a battery of genetically modified mice (HO-1-/-, HO-1, HO-2-/-, EC-SOD-/-, APN-/-, sEHKO, HO-1-Tg, EET-Tg, and APN-Tg) and developed a lentiviral gene transfer strategy to provide loss and gain ..
  14. IVUS Detection of Rupture Prone Plaques
    Marvin M Doyley; Fiscal Year: 2013
    ..we propose to conjugate a microbubble contrast agent to a peptide with the NGR-homing sequence that binds to CD13, and a monoclonal antibody, DC101, that binds to the VEGF receptor-2...
  15. A Drosophila model of motor neuron disease using mutations in P150 / Dynactin.
    Thomas Lloyd; Fiscal Year: 2012
    ..To investigate the role of vesicle transport in motor neuron disease, we have introduced a mutation in the P150 subunit of dynactin into Drosophila that is present in a rare familial form of ALS...
  16. Anxiety and Alcohol Drinking in a Genetic Animal Model of Alcoholism
    JULIA ANN CHESTER; Fiscal Year: 2010
    ..toward alcohol drinking behavior in mouse lines that have been selectively bred for high (HAP1 and HAP2) or low (LAP1 and LAP2) alcohol preference...
  17. Mechanisms of Vascular Dysfunction in Obesity & the Metabolic Syndrome
    ELAINE MOTT URBINA; Fiscal Year: 2010
    ..One of the pathways by which obesity induces target organ damage may involve fat derived adiponectin's (APN) effect on vascular function...
  18. Harriet L Robinson; Fiscal Year: 2014
    ..that form non-infectious virus like-particles (VLP) displaying trimeric gp160 envelope (DNA vaccines) or trimeric gp150 envelope (MVAVLP)...
  19. Regulation of synaptic plasticity by eCBs in adult and aged mammalian cortex
    Karen L Montey; Fiscal Year: 2012
    ..cortical inhibition indirectly through use of type 1 cannabinoid receptors (CBIRs) in adult postnatal day 150 (P150) and aged (P700) rats...
  20. UNIQUE SURFACE STRUCTURES ON SYNOVIAL CELLS
    DAVID ALAN FOX; Fiscal Year: 2011
    ..FLS surface structure induced by IL-17 but not TNF, and have shown that this molecule is the ecto-N-aminopeptidase CD13. Experiments are proposed to determine the functional consequences of this effect of IL-17...
  21. RICHARD LOWELL BELL; Fiscal Year: 2014
    ..This approach is most expedient because Dr. Ting-Kai Li (the PI who created our P/NP, HAD1-2/LAD1-2, and HAP1-2/LAP1-2 selected rodent lines) is now a Professor of Psychiatry at Duke and Drs. Amir H. Rezvani and Edward D...
  22. Natriuretic Mechanisms Uderlying Spontaneous Hypertension
    Shetal H Padia; Fiscal Year: 2012
    ..These enzymes, aminopeptidase A (APA) and aminopeptidase N (APN), repspectively are present in renal proximal tubule cells...
  23. Interactive Signaling Modules in Vascular Inflammation
    Linda H Shapiro; Fiscal Year: 2013
    ..Project 4 (Shapiro) focuses on the novel role of the cell-surface molecule CD13 in the adhesion of myeloid cells to vascular endothelial cells, and explores this mechanism in vascular pathology...
  24. Candece L Gladson; Fiscal Year: 2014
    ..of TNF-R1 with a TNFa fusion protein that is targeted to tumor MvECs by fusion with a peptide that binds CD13. We will use two mouse models to analyze the specificity of the effects and the magnitude of the responses in vivo: ..
  25. Fang Li; Fiscal Year: 2016
    ..angiotensin-converting enzyme 2 (ACE2) as its receptor, whereas other group-I coronaviruses use aminopeptidase-N (APN)...
  26. Brian D Perkins; Fiscal Year: 2016
    ..the apical transport of basal bodies preceding cilia formation by examining zebrafish mutants in dynein and the p150 and p50 subunits of dynactin...
  27. Stephen J King; Fiscal Year: 2014
    ..Our hypothesis is that the basic domain of dynactin p150 acts as a molecular tether to maintain contact between dynein, dynactin, cargo and the microtubule during motility ..
  28. GU Infection Self-Diagnosis for Deployed Military Women
    Nancy Ryan Wenger; Fiscal Year: 2004
    ..A research advanced practice nurse (APN) will enroll women in the study, conduct a protocol-driven clinical diagnostic examination, and treat the women ..
  29. Timothy A Springer; Fiscal Year: 2016
    ..Finally, the structure of the [unreadable]X[unreadable]2 headpiece bound to C3c will reveal the basis for specific ligand recognition and selectivity of [unreadable]X[unreadable]2 for iC3b. ..
  30. An Intervention to Improve Outcomes in Patients with Advanced Cancer
    Ruth McCorkle; Fiscal Year: 2011
    ..The study's overall purpose is to implement our evidence based Advanced Practice Nurse (APN) intervention using the RE-AIM model (Reach, Efficacy, Adoption, Implementation, Maintenance) to evaluate clinical ..
  31. HSV LATENCY AND MECHANISMS OF GENE SILENCING
    Joseph Glorioso; Fiscal Year: 2000
    ..in silencing ICPO expression (iv) To characterize cis-acting elements associated with two LAT promoters designated LAP1 and LAP2. (v) To determine the role of chromatin and DNA methylation in promoter silencing during latency...
  32. Xin Liang Ma; Fiscal Year: 2016
    ..Recent clinical and experimental results have demonstrated that adiponectin (APN) is a novel metabolic regulatory, vasculoprotective and cardioprotective molecule whose reduction found in diabetic ..
  33. Mechanisms of Mdm2/Mdmx in repressing p53
    Wei Gu; Fiscal Year: 2013
    ..In Aim 2, we will examine the regulatory role of p150, a newly identified Mdm2-associated protein, in controlling Mdm2 activities...
  34. MOLECULAR MARKER FOR INVASIVE CANDIDA ALBICANS
    MARGARET HOSTETTER; Fiscal Year: 2001
    ..and functionally related to the alpha subunits of the beta2 integrins alphaM (Mac-1 or CD11b/CD18) and alphaX (p150,95 or CD11c/CD18)--two members of the leukocyte adhesion glycoprotein family...
  35. C/EBPbeta Isoform Function & Regulation by Tyrosine Kinases
    Cynthia Zahnow; Fiscal Year: 2009
    ..Encoded by an intronless gene, C/EBPB is expressed as several distinct protein isoforms (LAP1, LAP2 and LIP) whose expression is tightly regulated by the differential use of a number of in-frame translation ..
  36. Telehealth nursing intervention for children with complex health care needs
    Stanley M Finkelstein; Fiscal Year: 2012
    ..that includes LPN-delivered care coordination and RN-delivered telephone triage, an intervention group receiving APN-delivered telephone care coordination and case management, and another intervention group receiving APN-delivered ..
  37. Ross S Summer; Fiscal Year: 2015
    ..Taken together, studies in this grant will identify the molecular mechanisms by which APN regulates lung vascular processes in the hope of identifying new avenues of research in lung vascular biology and ..
  38. CELLULAR CONCOMITANTS OF VINCRISTINE RESISTANCE
    JUNE BIEDLER; Fiscal Year: 1992
    ..While research in many laboratories has implicated P- glycoprotein (gp150-180) as a major factor, diverse characteristics of resistant cells suggest that other cell components may play ..
  39. BASOPHIL ACTIVATION AND RECRUITMENT IN ALLERGIC DISEASE
    Bruce Bochner; Fiscal Year: 1993
    ..quantitative measurement of the expression of surface adherence glycoproteins (CD11/CD18) including Mo1, LFA-1, and p150,95 on basophils in both impure and highly pure preparations...
  40. Hemolytic Anemia: Models
    LUANNE PETERS; Fiscal Year: 2006
    ..The p150 nb-Ank1 generated modulates the severity of the Hereditary Spherocytosis by apparent binding to the membrane, but ..
  41. LEUKOCYTE ADHESION RECEPTORS MAC 1 AND P150,95
    Timothy Springer; Fiscal Year: 2005
    ..We will test expression of alphaM subunit C-terminal fragments, define the boundaries of domains recognized by antibodies, and test such fragments for crystallization. ..
  42. IMPROVING HEALTH OUTCOMES IN UNPARTNERED CARDIAC ELDERS
    Sally Rankin; Fiscal Year: 2003
    ..Building upon these findings the proposed trial tests a collaborative Advanced Practice Nurse (APN)/Peer Advisor to improve health outcomes for unpartnered elders recovering from MI or CABG...
  43. FUNCTIONAL ROLE OF GP150-180 IN MULTIDRUG RESISTANCE
    AHMAD SAFA; Fiscal Year: 1991
    This project seeks to examine the role of gp150-180 in multidrug resistance (MDR) and its role in the circumvention of MDR by calcium channel blockers...
  44. STRUCTURE AND FUNCTION OF HUMAN C3 RECEPTORS
    Samuel Wright; Fiscal Year: 1991
    Leukocytes express a family of receptors, CR3, LFA-1, and p150, 95 that function in adhesion reactions...
  45. Assessing Angiogenesis by Near-Infrared Imaging
    Chun Li; Fiscal Year: 2005
    ..from in vivo phage-displaying technology can be used to home NIR fluorochromes to alpha v beta 3 integrin and CD13 receptors, respectively, in angiogenic tumor blood vessels...
  46. HUMAN CORONAVIRUS 229E SPIKE AND RECEPTOR INTERACTIONS
    Kathryn Holmes; Fiscal Year: 2001
    ..We identified human aminopeptidase N (hAPN), a membrane metalloprotease, as the receptor for human coronavirus 229E...
  47. REGULATION OF RECEPTOR-LIGAND INTERACTIONS
    PATRICIA DETMERS; Fiscal Year: 1993
    Human leukocytes express the CD11/CD18 family of receptors, LFA-1 CR3 and p150, 95 that mediates transient adhesion to ligand-coated cells, substrates, or particles...
  48. GENETIC MOUSE MODELS FOR CHRONIC INFLAMMATORY DISEASE
    Daniel Bullard; Fiscal Year: 2006
    ..MRL/MpJ-Faslpr mice containing mutations in ICAM-1, LFA-l, Mac-1 and P150/95 have now been generated and will be used to investigate the roles of leukocyte/endothelial interactions in ..
  49. DIFFERENTIATION AND FUNCTION OF HUMAN HELPER T CELLS
    SETH LEDERMAN; Fiscal Year: 2000
    ..our own, of a critical signalling element in the CD4O pathway, termed CD40-receptor associated factor 1 (CRAF1, LAP1, CD40bp)...
  50. Effects of Telemonitoring of HF Patients and Caregivers
    Karen Schwarz; Fiscal Year: 2004
    ..The proposed pilot study will evaluate whether electronic home monitoring (EHM) by an advanced practice nurse (APN) is more effective than usual home care in enhancing patient outcomes and decreasing hospital costs...
  51. MECHANISM OF INTERFERON ACTION
    CHARLES SAMUEL; Fiscal Year: 2009
    ..action are as follows: (1) To further characterize the biochemical and biophysical properties of the IFN-inducible p150 ADAR1...
  52. IMMUNOREGULATION IN DISSEMINATED HISTOPLASMOSIS
    WARD BULLOCK; Fiscal Year: 1990
    ..More particularly, the role of the common B chain of the family of adherence glycoproteins CR3/LFA-1/P150-,95 will be determined...
  53. CD13 as a Biomaker for Chemoprevention of Breast Cancer
    Linda Shapiro; Fiscal Year: 2009
    We have shown that the CD13/APN peptidase is a critical regulator of endothelial cell function and is required for angiogenesis. During endothelial cell activation, CD13/APN expression is induced by tumor-derived growth factors...
  54. Improving Use of CIS in the Underserved Through Mobile Access & Decision Support
    Suzanne Bakken; Fiscal Year: 2007
    ..existing personal digital assistant (PDA)-based mobile decision support system for advanced practice nurses (MODS-APN) increases use of tobacco-related CIS resources by APN students and the underserved populations for whom they ..
  55. MEMBRANE CYTOSKELETON INTERACTIONS IN NEUTROPHILS
    SUZANNE SUCHARD; Fiscal Year: 1992
    ..on two types of membrane proteins, a 140KD glycoprotein (distinct form the PMN adhesive glycoproteins MO-1 and p150,95), and membrane protein(s) that bind the extracellular matrix protein, platelet thrombospondin (TSP)...
  56. Mobile Decision Support for Advanced Practice Nursing
    Suzanne Bakken; Fiscal Year: 2007
    ..The specific aims of this study are to: (1) Extend an existing personal digital assistant-based (PDA) APN student clinical log (CL-APN) to include mobile decision support (MODS-APN]) for three CPGs of relevance across APN ..
  57. MECHANISMS OF GENE REGULATION IN MYELOPOIESIS
    James Downing; Fiscal Year: 1993
    ..This proposal focuses on two such genes, those encoding gp150 (CD13) and gp67 (CD33), which are expressed be committed human myeloid cell progenitors, subsets of more mature ..
  58. THE CHRONICALLY ILL--LONG TERM MECHANICAL VENTILATION
    Barbara Daly; Fiscal Year: 2003
    ..The intervention will consist of a disease-management program, implemented by a team of Advanced Practice Nurses (APN), pulmonologist, and geriatrician...
  59. NURSE PRACTICE FUNCTIONS--PATIENT PROBLEMS AND OUTCOMES
    Dorothy Brooten; Fiscal Year: 1999
    ..The second study purpose is to being establishing links between patient problems, APN practice functions, nurse time consumed, patient outcomes and health care costs...
  60. GENETIC ANALYSIS OF FUNGAL CYTOPLASMIC DYNEIN
    Michael Plamann; Fiscal Year: 1999
    ..ro-1 encodes the heavy chain of cytoplasmic dynein, while ro-3 and ro-4 encode the dynactin subunits p150(Glued) and Arp1, respectively...
  61. Assessing Circulating Progenitor Cells in Heart Disease
    Thomas Povsic; Fiscal Year: 2007
    ..cell surface expression of CD 133 and CD34, representative of late outgrowth endothelial progenitors, expression of CD13 and VEGFR-2, representative of early endothelial progenitors, and compare these progenitors with those identified ..
  62. QTL MAPPING FOR ALCOHOL PREFERENCE IN SELECTED MICE
    Paula Bice; Fiscal Year: 2004
    ..we also propose to do a fun genome screen to search for novel QTLs by using F2 animals generated from a HAP1 X LAP1 cross...
  63. CD154-CD13 Pathway in Inflammation-driven Angiogenesis
    Linda Shapiro; Fiscal Year: 2004
    ..Induction of both VEGF and the CD13/APN angiogenic regulator by the inflammatory mediator CD154 in endothelial cells establishes an essential link ..