CD11b

Summary

Gene Symbol: CD11b
Description: integrin subunit alpha M
Alias: CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, antigen CD11b (p170), cell surface glycoprotein MAC-1 subunit alpha, complement component 3 receptor 3 subunit, integrin, alpha M (complement component 3 receptor 3 subunit), leukocyte adhesion receptor MO1, macrophage antigen alpha polypeptide, neutrophil adherence receptor alpha-M subunit
Species: human

Top Publications

  1. ncbi The regulation of CD11b integrin levels on human blood leukocytes and leukotriene B4-stimulated skin by a specific leukotriene B4 receptor antagonist (LY293111)
    J P Van Pelt
    Department of Dermatology, University Hospital Nijmegen, The Netherlands
    Biochem Pharmacol 53:1005-12. 1997
  2. ncbi Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
    Q Liu
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Immunol 160:1393-401. 1998
  3. ncbi Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease
    Shlomo Rotshenker
    Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, POB 12272, Jerusalem 91120, Israel
    J Mol Neurosci 21:65-72. 2003
  4. ncbi P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils
    Yan Qing Ma
    University of Minnesota Medical School, MMC 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 104:2549-56. 2004
  5. ncbi CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
  6. ncbi Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor
    Makoto Nagata
    Pulmonary Division, Second Department of Internal Medicine, Saitama Medical School
    J Allergy Clin Immunol 109:676-80. 2002
  7. pmc Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism
    Simona Podgrabinska
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 183:1767-79. 2009
  8. pmc Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1
    Chiguang Feng
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Leukoc Biol 90:313-21. 2011
  9. doi Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation
    Federica Brugnoli
    Signal Transduction Unit Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, 44100 Ferrara, Italy
    Exp Cell Res 316:38-47. 2010
  10. doi Ketamine inhibits transcription factors activator protein 1 and nuclear factor-kappaB, interleukin-8 production, as well as CD11b and CD16 expression: studies in human leukocytes and leukocytic cell lines
    Ingeborg D Welters
    School of Clinical Science, University of Liverpool, The Duncan Building, Daulby St, Liverpool L69 3GA, UK
    Anesth Analg 110:934-41. 2010

Research Grants

  1. M Amin Arnaout; Fiscal Year: 2016
  2. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
  3. TIMOTHY CRAGIN WANG; Fiscal Year: 2015
  4. Tobias M Hohl; Fiscal Year: 2016
  5. Paul S Frenette; Fiscal Year: 2016
  6. Targeting renal inflammatory pathways of SLE nephritis in mouse and man
    Anne Davidson; Fiscal Year: 2013
  7. Regulation of CD8+ T Cell Homeostatis by IL-4
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2012
  8. ROBERTO IRENARDO VAZQUEZ PADRON; Fiscal Year: 2015
  9. NICOLE LEANNE WARD; Fiscal Year: 2016
  10. Elizabeth Scisci; Fiscal Year: 2015

Detail Information

Publications810 found, 100 shown here

  1. ncbi The regulation of CD11b integrin levels on human blood leukocytes and leukotriene B4-stimulated skin by a specific leukotriene B4 receptor antagonist (LY293111)
    J P Van Pelt
    Department of Dermatology, University Hospital Nijmegen, The Netherlands
    Biochem Pharmacol 53:1005-12. 1997
    b>CD11b is part of the beta2-integrin Mac-1 and plays an important role in neutrophil adhesion...
  2. ncbi Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
    Q Liu
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Immunol 160:1393-401. 1998
    ..into macrophages in serum-free medium, as assessed by expression of the alpha-subunit of the beta2 integrin CD11b, increased from 5 +/- 1% to 25 +/- 3%...
  3. ncbi Microglia and macrophage activation and the regulation of complement-receptor-3 (CR3/MAC-1)-mediated myelin phagocytosis in injury and disease
    Shlomo Rotshenker
    Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, POB 12272, Jerusalem 91120, Israel
    J Mol Neurosci 21:65-72. 2003
    ..Monoclonal antibody-induced phagocytosis regulation must reveal a mechanism by which native extracellular molecules bind to and regulate CR3/MAC-1-mediated myelin phagocytosis in microglia and macrophages...
  4. ncbi P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils
    Yan Qing Ma
    University of Minnesota Medical School, MMC 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 104:2549-56. 2004
    ..We thus propose a model in which P-selectin induces an intermediate state of integrin activation and then cooperates with other extracellular stimuli to support maximal adhesion of human neutrophils...
  5. ncbi CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
    ..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis...
  6. ncbi Leukotriene D4 upregulates eosinophil adhesion via the cysteinyl leukotriene 1 receptor
    Makoto Nagata
    Pulmonary Division, Second Department of Internal Medicine, Saitama Medical School
    J Allergy Clin Immunol 109:676-80. 2002
    ..Although the exact mechanism of action remains unknown, cysLTs might regulate the cellular responses involved in allergic inflammation...
  7. pmc Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism
    Simona Podgrabinska
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 183:1767-79. 2009
    ..Together, these data demonstrate a direct role of LECs in the modulation of immune response and suggest a function of the lymphatic endothelium in preventing undesired immune reactions in inflammatory conditions...
  8. pmc Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1
    Chiguang Feng
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Leukoc Biol 90:313-21. 2011
    ..Upon activation, β2 integrin (CD11b/CD18) on the PMN surface undergoes conformational change, which allows it to bind more tightly to the ICAM-1 and ..
  9. doi Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation
    Federica Brugnoli
    Signal Transduction Unit Laboratory of Cell Biology, Section of Human Anatomy, Department of Morphology and Embryology, University of Ferrara, 44100 Ferrara, Italy
    Exp Cell Res 316:38-47. 2010
    ..it strengthens the drug effects and is involved in the regulation of maturation-related proteins, such as the CD11b surface antigen...
  10. doi Ketamine inhibits transcription factors activator protein 1 and nuclear factor-kappaB, interleukin-8 production, as well as CD11b and CD16 expression: studies in human leukocytes and leukocytic cell lines
    Ingeborg D Welters
    School of Clinical Science, University of Liverpool, The Duncan Building, Daulby St, Liverpool L69 3GA, UK
    Anesth Analg 110:934-41. 2010
    ....
  11. pmc Sequential binding of αVβ3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils
    Pu Zhang
    Department of Bioengineering, The Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 186:242-54. 2011
    ..In addition, the involvement of integrin α(v)β(3), ICAM-1, and CD11b/CD18 (Mac-1) in fibrin(ogen)-mediated melanoma-PMN aggregations was explored...
  12. doi β2 integrin adhesion complexes maintain the integrity of HIV-1 assembly compartments in primary macrophages
    Annegret Pelchen-Matthews
    Cell Biology Unit, Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, WC1E 6BT, UK
    Traffic 13:273-91. 2012
    ..by immunolabelling of ultrathin cryosections that the β2 integrin CD18, together with the αM and αX integrins (CD11b and CD11c), is clustered at these coated domains, and that the coats themselves contain the cytoskeletal linker ..
  13. ncbi Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3
    Atsushi Kato
    Division of Hematology, Department of Internal Medicine and Division of Biochemical Analysis, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:28934-41. 2002
    ..As Aup1 possesses domains related to signal transduction, these results suggest involvement of Aup1 in the integrin signaling...
  14. doi Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles
    Robin van Bruggen
    Sanquin Research, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Mol Immunol 47:575-81. 2009
    ..cerevisiae or zymosan by human neutrophils. Phagocytosis of yeast particles proved to be completely dependent on CD11b/CD18, also known as complement receptor 3 (CR3)...
  15. pmc Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticles
    Elzbieta Pluskota
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, OH 44195, USA
    Blood 112:2327-35. 2008
    ..The presence and activation state of a multifunctional leukocyte receptor, integrin alpha(M)beta(2) (CD11b/18), on MPs derived from human neutrophils (PMNs) were examined...
  16. ncbi The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B
    A L Corbi
    Laboratory of Membrane Immunochemistry, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    J Biol Chem 263:12403-11. 1988
    ..These findings draw attention to this region of Mac-1 as a potential binding site for iC3b...
  17. ncbi Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/CD18)
    M W Johansson
    Department of Physiological Botany, University of Uppsala, Villavagen 6, Sweden
    J Cell Sci 110:1133-9. 1997
    ..However, adhesion to myeloperoxidase was inhibited by monoclonal antibodies to alpha M (CD11b) or to beta2 (CD18) integrin subunits, but not by antibodies to alpha L (CD11a), alpha M (CD11c), or to other ..
  18. ncbi Peptides derived from the complementarity-determining regions of anti-Mac-1 antibodies block intercellular adhesion molecule-1 interaction with Mac-1
    Y Feng
    Scios Inc, Sunnyvale, California 94086, USA
    J Biol Chem 273:5625-30. 1998
    ..1 CDR peptide with five residues randomized, we were able to identify a novel peptide inhibitor of Mac-1 with substitutions at all five positions. These peptides provide lead structures for development of Mac-1 antagonists...
  19. ncbi Mac-1 (CD11b/CD18) is crucial for effective Fc receptor-mediated immunity to melanoma
    Annemiek B van Spriel
    Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht, The Netherlands
    Blood 101:253-8. 2003
    ..This study documents an important role for the beta(2) integrin Mac-1 (CD11b/CD18) in FcR-mediated protection against melanoma...
  20. ncbi Regulation of CD11b/CD18 (Mac-1) adhesion to fibrinogen by urokinase receptor (uPAR)
    H Zhang
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, PA 19140, USA
    Inflamm Res 52:86-93. 2003
    ..The goal of this study is to investigate the consequence of the interaction between Mac-1 and uPAR and determine the mechanisms by which uPAR regulates Mac-1 dependent adhesion to fibrinogen...
  21. ncbi Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
    Anne Wetzel
    Department of Dermatology, University of Leipzig, Leipzig, Germany
    J Immunol 172:3850-9. 2004
    ..In this study, we have identified the specific interaction between human Thy-1 and the leukocyte integrin Mac-1 (CD11b/CD18; alphaMbeta2) both in cellular systems and in purified form...
  22. ncbi Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin
    Gerben Bouma
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Diabetes 53:1979-86. 2004
    ..control subjects but had a normal expression of the FN binding integrins CD29, CD49a, CD49d, and CD49e (although CD11b and CD18 expression was increased)...
  23. ncbi Multiple binding sites in fibrinogen for integrin alphaMbeta2 (Mac-1)
    Valeryi K Lishko
    J J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Biol Chem 279:44897-906. 2004
    ..This paradigm may have implications for mechanisms of promiscuity in ligand binding exhibited by integrin alphaMbeta2...
  24. ncbi Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1
    Khalid Sendide
    Department of Medicine, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada
    J Immunol 174:4210-9. 2005
    ..This converts low avidity CR3 into an active receptor leading to increased bacterial internalization...
  25. doi Myeloid cell differentiation in response to calcitriol for expression CD11b and CD14 is regulated by myeloid zinc finger-1 protein downstream of phosphatidylinositol 3-kinase
    Alireza Moeenrezakhanlou
    Department of Medicine Division of Infectious Diseases, University of British Columbia, Rm 452D, 2733 Heather St, Vancouver, BC V5Z 3J5, Canada
    J Leukoc Biol 84:519-28. 2008
    ..This is accompanied by increased expression of both CD11b and CD14 and has been shown to be phosphatidylinositol 3-kinase (PI3K) dependent...
  26. ncbi Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
    J O Lee
    Laboratory of X ray Crystallography, Dana Farber Cancer Institute, Harvard Medical School Boston, Massachusetts 02115
    Cell 80:631-8. 1995
    ..Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs...
  27. ncbi A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding
    M Michishita
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129
    Cell 72:857-67. 1993
    A recombinant peptide encoding the CD11b A domain bound 54Mn2+ with a high affinity. Other divalent cations, including Mg2+, Zn2+, Ni2+, Co2+, and Cd2+, but not Ca2+ or Ba2+, competed effectively for Mn2+ binding...
  28. ncbi Two conformations of the integrin A-domain (I-domain): a pathway for activation?
    J O Lee
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Structure 3:1333-40. 1995
    ....
  29. pmc Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
    D I Simon
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Exp Med 192:193-204. 2000
    ..These observations provide a molecular target for disrupting leukocyte-platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis...
  30. ncbi Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively
    Véronique Le Cabec
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Toulouse, France
    J Immunol 169:2003-9. 2002
    ..Therefore, CR3 mediates type I phagocytosis under nonopsonic conditions and type II under opsonic conditions. This is the first evidence that a single receptor can mediate both types of phagocytosis depending on the ligand used...
  31. ncbi Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils
    Klaas P J M van Gisbergen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    FEBS Lett 579:6159-68. 2005
    ..This indicates that glycosylation-driven binding of both Mac-1 and CEACAM1 to DC-SIGN is essential for interactions of neutrophils with DCs and enables neutrophils to modulate T cell responses through interactions with DCs...
  32. pmc The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function
    Mojca Skoberne
    New York University School of Medicine, 550 First Ave, MSB 507, New York, NY 10016, USA
    Blood 108:947-55. 2006
    ..This immunomodulatory role, however, is countered by a significant inflammatory stimulus such as bacterial infection. Overall, our data suggest that under steady-state conditions, signaling via CRs predominates to render DCs tolerogenic...
  33. doi Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways
    Fabrizio Montecucco
    Laboratory of Phagocyte Physiopathology, First Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa Medical School, Genoa, Italy
    Cell Signal 20:557-68. 2008
    ..TNF-alpha-induced migration was a consequence of the TNF-alpha-induced up-regulation of integrin CD11b/CD18 (Mac-1) on neutrophil surface...
  34. doi Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
    Geoffrey Hom
    Genentech, South San Francisco, CA 94080, USA
    N Engl J Med 358:900-9. 2008
    ..Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci...
  35. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    ..Our results show that numerous genes, some with known immune-related functions, predispose to SLE...
  36. doi A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus
    Swapan K Nath
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:152-4. 2008
    We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1...
  37. doi Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    E Y M G Fung
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 10:188-91. 2009
    ..70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus...
  38. pmc Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)
    Shizhong Han
    Genetic Epidemiology Unit, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Hum Mol Genet 18:1171-80. 2009
    ..Taken together along with our earlier findings, these results demonstrate that the coding variant, rs1143679, best explains the ITGAM-SLE association, especially in European- and African-derived populations, but not in Asian populations...
  39. pmc Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nat Genet 40:1059-61. 2008
    ..These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA...
  40. pmc ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong
    Hum Mol Genet 18:2063-70. 2009
    ..Therefore, despite the low-allele frequencies of the risk alleles of the gene in our two Asian populations, ITGAM was confirmed to be a risk factor related to disease susceptibility and probably severe manifestations of SLE...
  41. doi Rap1 controls activation of the α(M)β(2) integrin in a talin-dependent manner
    Jenson Lim
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London, UK
    J Cell Biochem 111:999-1009. 2010
    ..These results show that Rap1-mediated activation of α(M)β(2) in macrophages shares both common and distinct features from Rap1 activation of α(IIb)β(3) expressed in CHO cells...
  42. pmc Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts
    Baptiste Coustet
    Universite Paris Descartes, Rhumatologie A, Hopital Cochin, APHP, Paris, France
    J Rheumatol 38:1033-8. 2011
    ..To determine whether novel risk loci associated with systemic lupus erythematosus or multiple sclerosis may confer susceptibility to SSc, we tested single-nucleotide polymorphisms (SNP) from ITGAM, ITGAX, and CD58 for associations...
  43. pmc A systemic lupus erythematosus-associated R77H substitution in the CD11b chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis
    Matthew Macpherson
    Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom
    J Biol Chem 286:17303-10. 2011
    ..In addition, U937 cells expressing R77H-CD11b display increased IL-6 production as compared with WT-CD11b-expressing cells...
  44. pmc Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases
    Juan Manuel Anaya
    Center for Autoimmune Diseases Research CREA, Universidad del Rosario, Bogota, Colombia
    Autoimmun Rev 11:276-80. 2012
    ..Thus ITGAM may not be a general autoimmunity gene but this variant may be specifically associated with SLE and systemic sclerosis...
  45. pmc Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design
    Bhuvaneshwari Mahalingam
    Structural Biology Program, Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 187:6393-401. 2011
    ..As with other ligand-mimetic integrin antagonists, the function-blocking mAb 107 binds MIDAS of integrin CD11b/CD18 A domain (CD11bA), but in contrast, it favors the inhibitory Ca(2+) ion over the Mg(2+) ion at MIDAS...
  46. ncbi The fourth blade within the beta-propeller is involved specifically in C3bi recognition by integrin alpha M beta 2
    Yang Li
    Department of Vascular Biology, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:34395-402. 2003
    Interactions between the complement degradation product C3bi and leukocyte integrin alpha M beta 2 are critical to phagocytosis of opsonized particles in host defense against foreign pathogens and certain malignant cells...
  47. ncbi Human alloantibody anti-Mart interferes with Mac-1-dependent leukocyte adhesion
    Ulrich J H Sachs
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany
    Blood 104:727-34. 2004
    The CD11b/CD18 integrin plays a crucial role in cell-cell adhesion processes...
  48. pmc An essential role for talin during alpha(M)beta(2)-mediated phagocytosis
    Jenson Lim
    Centre for Molecular Microbiology and Infection, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United Kingdom
    Mol Biol Cell 18:976-85. 2007
    ..Remarkably, talin knockdown specifically abrogates uptake through complement receptor 3 (CR3, CD11b/CD18, alpha(M)beta(2) integrin) and not through the Fc gamma receptor...
  49. doi Integrin CD11c contributes to monocyte adhesion with CD11b in a differential manner and requires Src family kinase activity
    Thanae Georgakopoulos
    Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3128, Australia
    Mol Immunol 45:3671-81. 2008
    Integrin-mediated adhesion of human monocytes to fibrinogen regulated by CD11b/CD18 and the closely related integrin CD11c/CD18, play a key role in inflammation...
  50. ncbi Identification of a novel recognition sequence for integrin alphaM beta2 within the gamma-chain of fibrinogen
    T P Ugarova
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 273:22519-27. 1998
    The interaction of leukocyte integrin alphaMbeta2 (CD11b/CD18, Mac-1) with fibrinogen has been implicated in the inflammatory response by contributing to leukocyte adhesion to the endothelium and subsequent transmigration...
  51. pmc ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry
    Xana Kim-Howard
    Genetic Epidemiology Unit, Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Ann Rheum Dis 69:1329-32. 2010
    ..It was hypothesised that the coding variant (R77H), rs1143679, within ITGAM could predict specific clinical manifestations associated with systemic lupus erythematosus (SLE)...
  52. pmc The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1
    Sentot Santoso
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, D 35385 Giessen, Germany
    J Exp Med 196:679-91. 2002
    ..and described as a novel counterreceptor on platelets for the leukocyte beta2-integrin Mac-1 (alphaMbeta2, CD11b/CD18)...
  53. ncbi Identification and reconstruction of the binding site within alphaMbeta2 for a specific and high affinity ligand, NIF
    L Zhang
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 272:17558-64. 1997
    Engagement of the alphaMbeta2 (CD11b/CD18, Mac-1) integrin on neutrophils supports adhesion and induces various cellular responses. These responses can be blocked by a specific ligand of alphaMbeta2, neutrophil inhibitory factor (NIF)...
  54. ncbi Interaction of fibrin(ogen) with leukocyte receptor alpha M beta 2 (Mac-1): further characterization and identification of a novel binding region within the central domain of the fibrinogen gamma-module
    Sergiy Yakovlev
    University of Maryland School of Medicine, Rockville, Maryland 20855, USA
    Biochemistry 44:617-26. 2005
    ..The only alpha(M)I-binding activity was associated with the gamma228-253 peptide, indicating that this region of the central domain contains a novel alpha(M)beta(2)-binding sequence...
  55. ncbi Telmisartan inhibits beta2-integrin MAC-1 expression in human T-lymphocytes
    Andreas Link
    Klinik fur Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Hypertens 24:1891-8. 2006
    ..Although pro-inflammatory properties of angiotensin II as well as anti-inflammatory effects of AT1 receptor antagonists are well known, the underlying mechanisms are poorly understood...
  56. pmc Effect of interleukin-4 and interleukin-10 on leucocyte migration and nitric oxide production in the mouse
    M Perretti
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London
    Br J Pharmacol 116:2251-7. 1995
    ..Similarly, neither cytokine had any effect on the in vitro up-regulation of CD11b antigen on the surface of murine circulating neutrophils. 3. Treatment of mice with lipopolysaccharide (LPS, 0...
  57. ncbi Diagnostic and prognostic relevance of the immunophenotype in acute myelocytic leukemia
    V Callea
    Divisione di Ematologia, Ospedali Riuniti, Reggio Calabria, Italy
    Tumori 77:28-31. 1991
    ..Moreover, a constant negativity to HLA-DR and CD15 antigens in M3 and the contemporaneous expression of HLA-DR and CD11b antigens on the M4 and M5 leukemic cells were observed...
  58. ncbi [Role of polymorphonuclear leukocytes in development vascular complications in diabetes]
    Krzysztof Mastej
    Akademia Medyczna we Wroclawiu, Katedra i Klinika Angiologii, Nadciśnienia Tetniczego i Diabetologii
    Pol Merkur Lekarski 20:36-40. 2006
    ..The aim of this study was to evaluate the expression of the beta2-integrin (CD11b/CD18) and selectin-L (CD 62l) on the surface of the peripheral blood polymorphonuclear leukocytes in type 2 ..
  59. ncbi [Experimental study on the influence of alginate induced immune complex on BALF cells]
    M Ling
    First Department of Internal Medicine, Kyorin University, School of Medicine
    Kansenshogaku Zasshi 75:20-35. 2001
    ..neutrophil, lymphocyte, CD16/32 positive neutrophil, CD4+ lymphocyte, CD4+CD45+ lymphocyte, CD8+ lymphocyte, CD8+CD11b- lymphocyte were investigated along with the passage of time as compared with those of the non-immunized mice...
  60. ncbi Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury
    S G Soriano
    Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
    Stroke 30:134-9. 1999
    Macrophage-1 antigen (Mac-1) (CD11b/CD18), a leukocyte beta2 integrin, facilitates neutrophil adhesion, transendothelial migration, phagocytosis, and respiratory burst, all of which may mediate reperfusion-induced injury to ischemic ..
  61. ncbi RANK, RANKL, OPG, and M-CSF expression in stromal cells during corneal wound healing
    Steven E Wilson
    Cole Eye Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    Invest Ophthalmol Vis Sci 45:2201-11. 2004
    ..To examine the influx of monocytes into the cornea after epithelial scrape injury and the expression of chemokines that potentially regulate monocyte phenotype in cultured corneal fibroblasts and keratocytes in situ...
  62. ncbi [CD56 and CD11b antigen expressions in patients with acute monocytic leukemia and the clinical implications]
    Na Xu
    Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 50515, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:1605-8. 2009
    To investigate the expressions of cell surface differentiation antigen CD56 and CD11b antigen in acute monocytic leukemic (AML-M(5)) cells and their clinical significance.
  63. ncbi The expression of activity-dependent neuroprotective protein (ADNP) is regulated by brain damage and treatment of mice with the ADNP derived peptide, NAP, reduces the severity of traumatic head injury
    Illana Gozes
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Curr Alzheimer Res 2:149-53. 2005
    ..injury was associated with a delayed increase in the expression of the immune cell surface glycoprotein Mac-1 (CD11B antigen) at the injury site that was decreased in NAP-treated mice...
  64. ncbi Symptomatic lumbar spondylolysis. Neuroimmunologic studies
    D Nordstrom
    Fourth Department of Medicine, Helsinki University Central Hospital, Finland
    Spine (Phila Pa 1976) 19:2752-8. 1994
    ..This study characterized the defect using neuroimmunologic and inflammatory cell analysis...
  65. ncbi [Effect of erythromycin on neutrophil adhesion molecules]
    S Kusano
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Kansenshogaku Zasshi 67:7-11. 1993
    ..These findings indicate that EM does not directly reduce the expression of LFA-1 alpha, beta and Mac-1 on peripheral neutrophil obtained from healthy subjects...
  66. ncbi Immunohistochemical demonstration of subclasses of inflammatory cells and active, collagen-producing fibroblasts in the synovial plicae of lumbar facet joints
    Y T Konttinen
    Fourth Department of Medicine, University of Helsinki, Central Hospital, Finland
    Spine (Phila Pa 1976) 15:387-90. 1990
    ..Most of the immunoreactive cells observed were CD11b monocytes, and even these were only scattered in the connective tissue...
  67. ncbi The effect of ex vivo refrigerated storage and cell preservation solution (Cyto-Chex II) on CD11b expression and oxidative burst activity of dog neutrophils
    C G Ruaux
    The Gastrointestinal Laboratory, Small Animal Medicine and Surgery, Texas A and M University, College Station, TX 77843 4474, USA
    Vet Immunol Immunopathol 74:59-69. 2000
    The expression of CD11b and oxidative burst activity of dog neutrophils undergoing ex vivo refrigerated storage was studied using flow-cytometry ...
  68. pmc Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation
    Uwe Jerke
    Medical Faculty of the Charite, Experimental and Clinical Research Center, Berlin, Germany
    J Biol Chem 286:7070-81. 2011
    ..The NB1 signaling complex that was precipitated from plasma membranes contained the transmembrane receptor Mac-1 (CD11b/CD18) as shown by MS/MS analysis and immunoblotting...
  69. ncbi Regulation of leukocyte recruitment by polypeptides derived from high molecular weight kininogen
    T Chavakis
    Institute for Biochemistry, and, Third Department of Internal Medicine, Justus Liebig Universitat, Giessen, Germany
    FASEB J 15:2365-76. 2001
    ..behind a two-chain, high molecular weight kininogen (HKa) reported to bind to the beta2-integrin Mac-1 (CR3, CD11b/CD18, alphaMbeta2) on neutrophils and exert antiadhesive properties by binding to the urokinase receptor (uPAR) ..
  70. ncbi Platelet/polymorphonuclear leukocyte adhesion: a new role for SRC kinases in Mac-1 adhesive function triggered by P-selectin
    P Piccardoni
    Department of Vascular Medicine and Pharmacology, G Bizzozero Laboratory of Blood and Vascular Cell Interactions, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Blood 98:108-16. 2001
    ..This model highlights a new role for SRC kinases in a regulatory loop by which the Mac-1 promotes its own adhesive function...
  71. pmc Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin
    Andreia A Canalli
    Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil
    Haematologica 96:526-33. 2011
    ....
  72. ncbi [CD11b-positive cells expression in rectal mucosa from ovalbumin sensitized and challenged rabbits]
    Norberto Bassan
    Cátedra de Histología, Citología y Embriología, Facultad de Medicina de Rosario, Universidad Abierta Interamericana, Rosario, Argentina
    Acta Gastroenterol Latinoam 35:7-12. 2005
    Rabbit MAC-1 receptor, homologue to human CD11b is present in macrophages...
  73. doi The beta2 integrin CD11b attenuates polyinosinic:polycytidylic acid-induced hepatitis by negatively regulating natural killer cell functions
    Minggang Zhang
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, China
    Hepatology 50:1606-16. 2009
    The beta2 integrins play a key role in inflammation and immune responses. The beta2 integrin CD11b has been shown recently to be important in the maintenance of tolerance; however, the underlying mechanisms remain to be fully understood...
  74. ncbi Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation
    Bin Zhang
    Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:28443-54. 2003
    ....
  75. ncbi Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis
    Daniel C Bullard
    Department of Genetics, University of Alabama at Birmingham, 35294, USA
    J Immunol 175:6327-33. 2005
    Mac-1 (CD18/CD11b) is a member of the beta2-integrin family of adhesion molecules and is implicated in the development of many inflammatory diseases...
  76. pmc A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin
    Valeria V Orlova
    Experimental Immunology Branch, NCI, NIH, Bethesda, MD 20892, USA
    EMBO J 26:1129-39. 2007
    ..Together, a novel HMGB1-dependent pathway for inflammatory cell recruitment and activation that requires the functional interplay between Mac-1 and RAGE is described here...
  77. ncbi Engagement of CD11b and CD11c beta2 integrin by antibodies or soluble CD23 induces IL-1beta production on primary human monocytes through mitogen-activated protein kinase-dependent pathways
    R Rezzonico
    Division of Immunology and Allergy, Clinical Immunology Unit Hans Wilsdorf Laboratory, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Blood 95:3868-77. 2000
    ..We demonstrate that ligation of CD11b (Mac-1, CR3) or CD11c (p150, CR4) alpha chains of beta2 integrins by mAbs or soluble chimeric CD23 (sCD23) on ..
  78. ncbi Sequence gamma 377-395(P2), but not gamma 190-202(P1), is the binding site for the alpha MI-domain of integrin alpha M beta 2 in the gamma C-domain of fibrinogen
    Tatiana P Ugarova
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Biochemistry 42:9365-73. 2003
    The interaction between the leukocyte integrin alpha(M)beta(2) (CD11b/CD18, Mac-1, CR3) and fibrinogen mediates the recruitment of phagocytes during the inflammatory response...
  79. ncbi Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice
    A R Rosenkranz
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 161:6463-7. 1998
    Mac-1 (CD11b/CD18, CR3), a beta2 integrin expressed on leukocytes, is important in leukocyte migration...
  80. ncbi Downregulation of mac-1 expression in monocytes by surface-bound IgG
    P X Fernández-Calotti
    Laboratorio de Immunologia, IIHEMA, Academia Nacional de Medicina, Buenos Aires, Argentina
    Scand J Immunol 57:35-44. 2003
    Physical and functional association between the beta2-integrin Mac-1 (CD11b/CD18) and receptors of immunoglobulin G (IgG) (FcgammaRs) has been previously reported...
  81. ncbi Stent-induced expression and activation of the leukocyte integrin Mac-1 is associated with neointimal thickening and restenosis
    Teruo Inoue
    Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine, 2 1 50 Minamikoshigaya, Koshigaya City, Saitama 343 8555, Japan
    Circulation 107:1757-63. 2003
    Increased expression of the beta2 integrin Mac-1 (CD11b/CD18, alphaMbeta2), which is responsible for firm leukocyte adhesion to platelets and fibrinogen at injured vessels, is found in association with neointimal hyperplasia after ..
  82. ncbi Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury
    Xiao Pei Gao
    Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Physiol Genomics 21:230-42. 2005
    To inactivate chronically the beta2-integrin CD11b (Mac-1), we made a transgenic model in mice in which we expressed the CD11b antagonist polypeptide neutrophil inhibitory factor (NIF)...
  83. ncbi Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage
    N J Fardon
    Department of Medicine, University of Newcastle-upon-Tyne, United Kingdom
    Am J Hypertens 14:927-33. 2001
    ..Neutrophil accumulation, which occurs by beta2-integrin (CD11b/CD18) expression, followed by release of proinflammatory factors from primary vesicles is an important factor in ..
  84. ncbi Cloning of the rat CR3 alphaM (CD11b) subunit, expression and binding assay of recombinant isolated CD11b VA (A-domain) and ICAM-1 Ig modules
    K Zerria
    Molecular Biotechnology Group, Immunology Laboratory, Institut Pasteur de Tunis, Tunisia
    Arch Inst Pasteur Tunis 79:11-7. 2002
    ..We have isolated cDNA clones-coding for the rat complement receptor type 3 (CR3) alphaM subunit (CD11b) from a cDNA library. The cDNA sequence showed respectively 89.4% and 74...
  85. ncbi Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy
    B Lange-Sperandio
    Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
    Kidney Int 69:81-8. 2006
    ..ICAM-1 and its new ligands RAGE and JAM-C are sequentially activated in UUO. Blocking of Mac-1 and its ligands may confer synergistic renoprotective effects in neonatal obstructive nephropathy...
  86. ncbi [Changes of neutrophil functions after cardiopulmonary bypass: experiment with dogs]
    Jing Zhou
    Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
    Zhonghua Yi Xue Za Zhi 88:1206-10. 2008
    ..To investigate if increase of adhesion function and capability to destroy and decrease of phagocytosis of neutrophils occur after cardiopulmonary bypass (CPB)...
  87. ncbi [IL-27 regulates the expression of Mac-1, fMLP-R and IL-1beta in human neutrophils through p38 MAPK and PI3K signal pathways]
    Jian Ping Li
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:391-5. 2010
    ..It is concluded that the IL-27 may regulate the expression of Mac-1, fMLP-R and IL-1beta in human neutrophils through p38 MAPK and PI3K signal pathways...
  88. pmc LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ
    Ronen Sumagin
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 185:7057-66. 2010
    ..Using function-blocking Abs, we show that these different crawling patterns were due to CD11a/CD18 (LFA-1)- versus CD11b/CD18 (Mac-1)-mediated crawling...
  89. ncbi Monocyte adhesion molecule expression in interstitial inflammation in patients with renal failure
    Elham Dadfar
    Department of Clinical Immunology, Karolinska Hospital, Stockholm, Sweden
    Nephrol Dial Transplant 19:614-22. 2004
    ..We therefore studied the recruitment of monocytes and their expression of adhesion molecules CD11b and CD62L at the site of interstitial inflammation in patients with renal failure...
  90. ncbi 1H-cyclopenta[b]benzofuran lignans from Aglaia species inhibit cell proliferation and alter cell cycle distribution in human monocytic leukemia cell lines
    F I Bohnenstengel
    Department of Pharmaceutical Biology, Julius von Sachs Institute of Biosciences, , Germany
    Z Naturforsch C 54:1075-83. 1999
    ..Our data suggests that 1H-cyclopenta[b]benzofuran lignans of the rocaglamide type act primarily by a cytostatic mechanism...
  91. ncbi [Effects of Staphylococcus aureus protein A on the production of primary host defense factors against S. aureus infection]
    N Endo
    Department of Immunology, Kyorin University School of Health Sciences
    Kansenshogaku Zasshi 71:39-45. 1997
    ..on the production of fibronectin (Fn) and the third component of complement (C3) by macrophages and that of CD11b, CD49e and H2O2 by granulocytes...
  92. ncbi Effects of the AT1 receptor antagonist on adhesion molecule expression in leukocytes and brain microvessels of stroke-prone spontaneously hypertensive rats
    K Takemori
    Department of Pathology, Kinki University School of Medicine, Osaka, Japan
    Am J Hypertens 13:1233-41. 2000
    ..Thus, AII seems to be an important mediator for the hypertensive microvascular injuries...
  93. ncbi Impaired transendothelial migration by neonatal neutrophils: abnormalities of Mac-1 (CD11b/CD18)-dependent adherence reactions
    D C Anderson
    Department of Pediatrics, Baylor College of Medicine, Houston, TX
    Blood 76:2613-21. 1990
    In order to evaluate the functions of lymphocyte function antigen-1 (LFA-1) (CD11a/CD18) and Mac-1 (CD11b/CD18) on neonatal neutrophils, we examined neutrophil adhesion to and migration through human umbilical vein endothelial cell (..
  94. ncbi Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils
    S B Shappell
    Speros P Martel Leukocyte Biology Laboratory, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030
    J Immunol 144:2702-11. 1990
    ..the possible role of one integrin known to participate in the adhesion of neutrophils to endothelial cells, CD11b/CD18 (Mac-1)...
  95. ncbi Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1
    M A Jutila
    Department of Pathology, Stanford University Medical Center, CA 94305
    J Immunol 143:3318-24. 1989
    ..These results confirm that both the MEL-14 antigen and Mac-1/LFA-1 are important in neutrophil localization to inflamed sites in vivo, but suggest that their roles in endothelial cell interactions are distinct...
  96. ncbi [Analysis of complement-mediated phagocytosis in systemic lupus erythematosus model mice, NZB/W F1]
    T Onogawa
    Department of Immunology and Pathology, School of Health Sciences, Kyorin University
    Kansenshogaku Zasshi 68:332-8. 1994
    ....
  97. ncbi Downmodulation of CXCL8/IL-8 receptors on neutrophils after recruitment in the airways
    Patrizia Pignatti
    Servizio Autonomo di Allergologia e Immunologia Clinica, Fondazione Salvatore Maugeri, IRCCS, Pavia, Italy
    J Allergy Clin Immunol 115:88-94. 2005
    ..CXCL8/IL-8 is the most significant chemokine for neutrophils, and CXC chemokine receptor (CXCR) 1 and 2 are its 2 receptors, which are downmodulated by CXCL8/IL-8 and endotoxin on activated neutrophils...
  98. ncbi Brief hypoxia conditions monocytes to protect reperfused cardiocytes against cell death via the CD11b receptor
    Mark L DaCosta
    Section of Cardiac and Thoracic Surgery, University of North Carolina, Chapel Hill, USA
    J Heart Lung Transplant 22:979-85. 2003
    ..This study sought to determine whether cultured human monocytes can be pre-conditioned by brief hypoxia to protect cardiomyocytes from cell death after hypoxia and re-oxygenation...
  99. ncbi [Soluble proteins from Staphylococcus aureus can change expression of CD11b and CD62L, but not H2O2 production by human blood granulocytes]
    T Onogawa
    Department of Immunology, School of Health Sciences, Kyorin University
    Kansenshogaku Zasshi 73:328-35. 1999
    We examined the production of CD11b, CD62L and H2O2 by human peripheral blood granulocytes after treatment with soluble proteins prepared from five different pressure-disrupted strains of Staphylococcus aureus (SaSP) by flow cytometory...
  100. ncbi Impaired monocyte CD11b expression in interstitial inflammation in hemodialysis patients
    P Thylén
    Department of Nephrology, Karolinska Hospital and Karolinska Institute, Stockholm, Sweden
    Kidney Int 57:2099-106. 2000
    ..expression induced by hemodialysis influence the recruitment of monocytes and their ability to up-regulate CD11b at the local site of inflammation in the interstitium...
  101. ncbi Effect of short-term cocaine administration on the immune system of young and old C57BL/6 female mice
    L L Colombo
    Arizona Prevention Center, College of Medicine, University of Arizona, Tucson 85724, USA
    Immunopharmacol Immunotoxicol 21:755-69. 1999
    ..Cocaine only decreased the absolute number of Thy 1+, CD4+, CD8+, IL-2R+, Mac 1+ and B cells, in the spleen of old mice...

Research Grants62

  1. M Amin Arnaout; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The beta2 integrin CD11b/CD18, the most abundant leukocyte integrin, is normally kept in an inactive (low affinity) state on circulating neutrophils and monocytes...
  2. Mac-1 (CR3) and Fc gamma receptors in immune-mediated neutrophil cytotoxicity
    Tanya N Mayadas; Fiscal Year: 2013
    ..This could lead to the identification of targeted therapeutic strategies that attenuate organ injury while minimally immunocompromising the host. ..
  3. TIMOTHY CRAGIN WANG; Fiscal Year: 2015
    ..from our laboratory using HDC-EGFP BAC transgenic reporter mice has demonstrated that HDC is highly expressed in CD11b+Ly6G+ immature myeloid cells (IMCs) that exhibit cell surface markers similar to myeloid-derived suppressor cells (..
  4. Tobias M Hohl; Fiscal Year: 2016
    ..fumigatus challenge. Recruited monocytes form monocyte-derived CD11b+ DCs, transport fungal antigen to draining lymph nodes, and facilitate the priming of fungus-specific CD4 T cells ..
  5. Paul S Frenette; Fiscal Year: 2016
    ..These studies will provide new insight on the mechanisms regulating sickle cell VOC and lead to novel ways to target inflammation. ..
  6. Targeting renal inflammatory pathways of SLE nephritis in mouse and man
    Anne Davidson; Fiscal Year: 2013
    ..Our studies should help us identify new pathogenetic disease mechanisms, to find novel targets for therapeutic intervention and to identify robust biomarkers that will help predict outcomes and responses to therapy. ..
  7. Regulation of CD8+ T Cell Homeostatis by IL-4
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2012
    ..Suppression is associated with the appearance of an enlarged, activated population of CD11b+Ly6Ghi neutrophils, which have been implicated by other investigators in the inactivation and killing of activated ..
  8. ROBERTO IRENARDO VAZQUEZ PADRON; Fiscal Year: 2015
    ..The integrin Mac-1 (also known as CD11b/CD18, CR3, and [unreadable]M[unreadable]2), which is primarily expressed on leukocytes, plays a key role in ..
  9. NICOLE LEANNE WARD; Fiscal Year: 2016
    ..on a wild type background spontaneously develop atherosclerotic plaque and have elevated levels of pro-atherogenic CD11b+Ly-6Chi monocytes...
  10. Elizabeth Scisci; Fiscal Year: 2015
    ..Understanding the nature of these reactions between DCs and PMNs to P. gingivalis may lead to the detailed insight required for more effective means of treating chronic periodontitis. ..
  11. HARRIS R PERLMAN; Fiscal Year: 2016
    ..An adoptive transfer model in which macrophages are specifically depleted using a CD11b-diphtheria toxin receptor construct will be used to test whether macrophages are required for the development of ..
  12. JUSTIN RODNEY SAVAGE; Fiscal Year: 2015
    ....
  13. Michael A Hill; Fiscal Year: 2015
    ..We also propose that in a diabetic model with Diptheria toxin induced deletion of macrophages (db/db x CD11b-DTR;this is a mouse model which expresses the human diphtheria toxin receptor [DTR] under the control of the CD11b ..
  14. Julie Anne Saugstad; Fiscal Year: 2016
    ..MMP)-9 expression in male monocytes, thus facilitating their transmigration;(c) male mice deficient in CD11b+ (macrophage "knockout") or in CD11c+ myeloid cells (dendritic cell "knockout") will more greatly benefit by loss ..
  15. Lipoprotein Receptors and Inflammation in the Vessel Wall
    Dudley K Strickland; Fiscal Year: 2011
    ..abstract_text> ..
  16. Hedgehog Signaling in Intestinal Tolerance and Inflammation
    Michelle M Muza-Moons; Fiscal Year: 2013
    ..Second, we will determine whether Hh ligand is sufficient to promote tolerance in CD11b+ myeloid cells, including dendritic cells and macrophages, in vitro;quantitative real-time RT-PCR, ELISA assays ..
  17. The Role of Microglia in Prolonged Anxiety-like Behavior following Social Stress
    Eric S Wohleb; Fiscal Year: 2013
    ..2) repeated social defeat (RSD), the inflammatory potential of peripheral myeloid-lineage cells and monocytes (CD11b+) is enhanced and following immune stimulation these cells produce more pro-inflammatory cytokines...
  18. Bordetella adenylate cyclase toxin: the role of cell interaction in toxin functio
    JOSHUA CLARK EBY; Fiscal Year: 2013
    ..The magnitude of intoxication correlates with the relative surface expression of the (32 integrin, CD11b/CD18, a receptor expressed most abundantly on neutrophils and macrophages;however, the relationship between AC ..
  19. Tatiana P Ugarova; Fiscal Year: 2016
    PROJECT SUMMARY/ABSTRACT Leukocyte integrin aMb2 (CD11b/CD18, Mac-1) plays a pivotal role in normal protective inflammatory response and pathological inflammation...
  20. Pulmonary defense against aspergillus fumigatus
    Chad Steele; Fiscal Year: 2013
    ..fumigatus challenge are surprisingly not lymphoid in origin, but rather myeloid CD11b+ and CD11c+ cell populations, which produce IL-17 in a Dectin-1 dependent manner...
  21. Preclinical Evaluation of PK2 Antagonists for Pancreatic Cancer
    Xiao Fan Wang; Fiscal Year: 2012
    ..b>CD11b+Gr1+ myeloid cells are the main source of PK2 production in response to stimulation by the cytokine GCSF...
  22. Alpha M Beta 2 integrin blockade for acute inflammatory neuropathies
    EROBOGHENE EKAMERENO UBOGU; Fiscal Year: 2013
    ..nerve inflammation, we propose to address a fundamental question: Is blockade of [unreadable]M integrin (CD11b) a potential treatment strategy for acute peripheral neuritis? Based on our exciting new preliminary data using in ..
  23. Beta2 Integrin Activation and Signaling
    Vineet Gupta; Fiscal Year: 2010
    ..to develop and test specific, structure-based hypotheses for integrin activation, with a focus on beta2 integrin CD11b/CD18, by using alphaVbeta3 structure as the model for the CD11b/CD18 integrin...
  24. Daniel I Simon; Fiscal Year: 2016
    ..During the period of this grant (years 11-14), we have continued to focus on the leukocyte integrin Mac-1 (aMPa. CD11b/CD18), identifying this adhesive receptor as a critical molecular determinant of leukocyte recruitment and ..
  25. Marie Dominique Filippi; Fiscal Year: 2014
    ..mechanistic level, we have identified a new pathway mediating Cdc42 functions and involving the leukocyte integrin CD11b/CD18...
  26. Jaehyung Cho; Fiscal Year: 2015
    ..A better understanding of how surface PDI regulates b2 integrin-mediated neutrophil recruitment into the site of inflammation may lead to the development of novel therapeutics to prevent and treat inflammation and tissue injury. ..
  27. LEUKOCYTE INTEGRIN ALPHA M BETA 2
    Edward Plow; Fiscal Year: 2004
    ....
  28. Sex Differences and Estrogen Receptors Regulate Dendritic Cells in Inflammation
    Susan Kovats; Fiscal Year: 2010
    ..the transcription factor interferon regulatory factor 4 (IRF4), which leads to a developmental program underlying CD11b+ DC differentiation...
  29. Michal Mrug; Fiscal Year: 2016
    ....
  30. CELL SURFACE ANTIGENS ON HUMAN MACROPHAGES
    Robert Todd; Fiscal Year: 1999
    ..As an outgrowth of these efforts, we have accumulated data that suggest that the Mo1 (CD11b/CD18) integrin glycoprotein not only serves as a traditional receptor for well-defined ligands such as ICAM-1 (..
  31. Genetic and Cellular Determinants of Arterial Thrombosis
    Roy L Silverstein; Fiscal Year: 2010
    ..Core F will provide a curriculum and career development support for physicians training in clinical thrombosis research in SCCOR laboratories. ..
  32. Reza Dana; Fiscal Year: 2016
    ..of DED except that disease activity is sustained by ongoing activation and infiltration of the ocular surface by CD11b+ monocytes and CD4+ T cells...
  33. Inhibition of platelet-leukocyte interactions to treat TRALI
    Paul S Frenette; Fiscal Year: 2010
    ..In this proposal, we will perform translational studies and develop new tools in preparation of a clinical trial to treat and/or prevent TRALI. ..
  34. Oncolytic Viruses with Therapeutic Genes in the Treatment of Breast Cancer
    DANUTA B KOZBOR; Fiscal Year: 2013
    ..collapse associated with a loss of blood flow to the interior of the tumor and infiltration by peripheral Gr1+CD11b+ neutrophils...
  35. Delisa Fairweather; Fiscal Year: 2015
    ..with testosterone reducing CR1/2 during coxsackievirus B3 (CVB3) myocarditis resulting in increased Th1, C3, CD11b/CR3 inflammation, DCM and heart failure in male mice, and that interleukin (IL)-4/Th2 increases CR1/2 expression ..
  36. MMPs, Integrins and Microglial activation in HAND
    KATHLEEN ANNE MAGUIRE-ZEISS; Fiscal Year: 2013
    ..Further study of the receptors that underlie MMP dependent effects is also clinically relevant. At least one soluble CAM can interact with LFA-1, a microglial integrin for which a clinically tolerable antagonist has been developed. ..
  37. Timothy L Denning; Fiscal Year: 2016
    ..Conversely, we discovered that CD103-expressing LP DCs are poor producers of IL-10 and the CD11b+ LP DC subset expresses TGF? and IL-6 and drives the differentiation of Th17 cells both in vitro and in vivo...
  38. Lionel B Ivashkiv; Fiscal Year: 2016
    ..We anticipate that our studies will yield insights into regulation of cytokine production that can be exploited for therapeutic interventions to suppress autoimmunity and inflammation. ..
  39. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
    ..Preliminary phenotyping suggests a role for signaling by the IL-4Ra on MHC Class II+, CD11b+ mononuclear cells and on eosinophils. It is not known if these cells are primarily responding to IL-4 or IL-13...
  40. Timothy R Billiar; Fiscal Year: 2016
    ..By fully characterizing the TLR4, CD11b/CD18-dependent signaling pathways involved in HC LPS uptake, we will define and functionally characterize a TLR4-..
  41. Marta Torroella-Kouri; Fiscal Year: 2014
    ..There is an urgent need to build up studies to better understand the biology of cancers across ethnicities, and to develop tools that will more accurately predict their prognosis and design their customized treatment strategies. ..
  42. Mechanism of immune regulation by CD11b+ myeloid cells in the intestine
    Masako Murai; Fiscal Year: 2013
    ..as a key mediator of intestinal immune homeostasis, however, we have found IL-10 derived from intestinal F4/80+ CD11b+ CD11cint macrophages acts directly on regulatory T cells (Treg) and maintains their suppressive function in a ..
  43. Inflammatory Mechanisms In Insulin Resistance
    JEFFREY ALAN DEIULIIS; Fiscal Year: 2011
    ..2. Demonstrate that adipose tissue-derived macrophages (CD11b+ cells) and dendritic cells (CD11c+ cells) prevent Treg differentiation in-vitro and to elucidate the mechanism. 3...
  44. Pro-inflammatory S100A12 in atherosclerosis and acute coronary syndrome
    MARION A HOFMANN-BOWMAN; Fiscal Year: 2012
    ..targeted to the smooth muscle cells by using the SM22-a promoter and targeted to macrophages by using the CD11b promoter...
  45. Subra Kugathasan; Fiscal Year: 2016
    ..rare coding region mutations in genes predicted to affect GM-CSF priming of bacterial killing (CSF2RB &ITGAM/CD11b) and neutrophil oxidative burst (CYBA/p22phox), while EO patients have exhibited increasing titers of GM-CSF Ab...
  46. Nathan E Welty; Fiscal Year: 2015
    ..recently been appreciated that the CD103+ DC population actually contains two distinct subsets distinguished by CD11b expression...
  47. Vijay K Kuchroo; Fiscal Year: 2016
    ..Tim-4 has relatively restricted expression in that it is largely expressed on activated DCs and some subsets of CD11b+ macrophages in tissue inflammation...
  48. Vineet Gupta; Fiscal Year: 2015
    ..The leukocytic 2 integrin CD11b/CD18 (a.k.a. Mac-1, aMb2) is central to various functions of these cells...
  49. Regulation of dendritic cells by estrogen receptors during influenza infection
    Susan Kovats; Fiscal Year: 2012
    ..shown that estradiol/ER1 signaling promotes the GM-CSF-driven inflammatory pathway that leads to development of CD11b+ DC. These DC have features of the tissue and inflammatory DC that are crucial during influenza infection...
  50. Effect of Bone Marrow Cells on the Radiosensitivity of Brain and Mouth Cancers
    JOHN MARTIN BROWN; Fiscal Year: 2012
    ..We have obtained strong evidence for the validity of this hypothesis by showing that MMP-9 expressing CD11b+ monocytes are recruited to tumors following irradiation, that tumors cannot grow in an irradiated site without ..
  51. Vipin Kumar; Fiscal Year: 2016
    ..Adoptive transfer experiments or depletion of conventional cDC or CD11b+Gr-1+ cells, respectively in NKT cell activation and in ALD will be studied...
  52. Gary E Landreth; Fiscal Year: 2016
    ..novel model for HIV-induced neurodegeneration using latently infected mouse monocytes to repopulate the brains of CD11b-HSVTK transgenic mice where microglial cells have been depleted...
  53. Multipotent lung mesenchymal cells in neonatal lung injury
    Marc B Hershenson; Fiscal Year: 2010
    ..The cells are positive for Stro-1, CD73, CD90, CD105 and CD166, but negative for CD34, CD45 and CD11b, suggesting that they are of stromal but not hematopoietic origin...
  54. KLF4, myeloid development, and transplantation arteriosclerosis
    A K M KHYRUL WARA; Fiscal Year: 2010
    ..of KLF4 alone in the human promyelocytic cell line, HL-60, confers the morphologic, genetic (M-CSFR, CD11b, CD14), and functional (adhesion and phagocytosis) characteristics of a mature monocyte...
  55. JOHN MARTIN BROWN; Fiscal Year: 2015
    ..Targeting both the local tumor and vasculogenesis, primarily mediated by CD11b+ myelomonocytes and circulating endothelial cells (ECs), is a novel paradigm and could lead to a major increase in ..
  56. Host Cell Assisted Primary and Metastatic Tumor Regrowth after Chemotherapy
    Robert S Kerbel; Fiscal Year: 2013
    ..g. Gr1+CD11b+ myeloid cells or tie-2 expressing monocytes, among others...
  57. HTS Assay for Discovery:Small Molecule Regulators (RMI)
    Vineet Gupta; Fiscal Year: 2005
    ..The CD11b/CD18 (alpha-M-beta2) heterodimer is the predominant beta2 integrin receptor in neutrophils and macrophages and ..
  58. ISOLATED PSGL-1 AND MAC-1 ADHESION TO ENDOTHELIUM
    DOUGLAS GOETZ; Fiscal Year: 2003
    ..abstract_text> ..
  59. CD11B/CD18 AND NEUTROPHIL EPITHELIAL INTERACTIONS
    CHARLES PARKOS; Fiscal Year: 2003
    ..we have shown that PMN transepithelial migration requires specific regions of the neutrophil beta2 integrin CD11b/CD18 and is independent of selectins and ICAM-1...
  60. GENETIC MOUSE MODELS FOR CHRONIC INFLAMMATORY DISEASE
    Daniel Bullard; Fiscal Year: 2006
    ..cells; and (iv) determine whether MRL/MpJ-Faslpr mice with null mutations in the ICAM-1 ligands CD11a (LFA-1), CD11b (Mac-1), or CD11c (p150/95) will alter development and progression, organ distribution, or inflammatory ..
  61. THE PROTEIN C RECEPTOR AND WEGENER'S VASCULOPATHY
    Shinichiro Kurosawa; Fiscal Year: 2003
    ..to the beta2 chain of the leukocyte adhesion molecules (CD18) and an antibody to the unique alpha chain of Mac-1 (CD11b) also block binding of soluble EPCR to activated neutrophils...
  62. John F Sheridan; Fiscal Year: 2016
    ..Moreover, following SDR we show that these bone marrow-derived MPCs (CD11b+/Ly6Chigh/CCR2+) traffic to specific brain regions...