CD105

Summary

Gene Symbol: CD105
Description: endoglin
Alias: END, HHT1, ORW1, endoglin, CD105 antigen
Species: human

Top Publications

  1. pmc Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia
    Aparna Reddy
    Fetal Medicine Unit, Elizabeth Gareth Anderson Hospital, University College Hospital, London, United Kingdom
    PLoS ONE 4:e4453. 2009
  2. doi Increased expression of the transforming growth factor-beta signaling pathway, endoglin, and early growth response-1 in stable plaques
    Pieter T G Bot
    Department of Cardiology, AMC Amsterdam, The Netherlands
    Stroke 40:439-47. 2009
  3. doi First-trimester serum levels of soluble endoglin and soluble fms-like tyrosine kinase-1 as first-trimester markers for late-onset preeclampsia
    Marc U Baumann
    Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
    Am J Obstet Gynecol 199:266.e1-6. 2008
  4. ncbi Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain
    Barbara A Conley
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Biol Chem 279:27440-9. 2004
  5. ncbi Endoglin structure and function: Determinants of endoglin phosphorylation by transforming growth factor-beta receptors
    Rositsa I Koleva
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Biol Chem 281:25110-23. 2006
  6. ncbi Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins
    Francisco Sanz-Rodriguez
    Centro de Investigaciones Biologicas, CSIC, Ramiro de Maetzu 9, 28040 Madrid, Spain
    J Biol Chem 279:32858-68. 2004
  7. ncbi Angiogenesis index CD105 (endoglin)/CD31 (PECAM-1) as a predictive factor for invasion and proliferation in intraductal papillary mucinous neoplasm (IPMN) of the pancreas
    Michael Tachezy
    Department of General, Visceral, and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Germany
    Histol Histopathol 25:1239-46. 2010
  8. ncbi Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan
    Miwako Dakeishi
    Department of Hygiene, Akita University School of Medicine, Akita, Japan
    Hum Mutat 19:140-8. 2002
  9. ncbi Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer
    Pernilla Wikstrom
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Prostate 51:268-75. 2002
  10. pmc Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, PO Box 33932, Shreveport, Louisiana 71130, USA
    J Clin Endocrinol Metab 93:260-6. 2008

Research Grants

  1. Isolation of novel mesenchymal stem cell subpopulations
    Buddhadeb Dawn; Fiscal Year: 2009
  2. Buddhadeb Dawn; Fiscal Year: 2016
  3. Multipotent lung mesenchymal cells in neonatal lung injury
    Marc B Hershenson; Fiscal Year: 2010
  4. Seyedtaghi Takyar; Fiscal Year: 2015
  5. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2012
  6. Nam Y Lee; Fiscal Year: 2014
  7. Mechanism and therapy for arteriovenous malformation
    Suk Paul Oh; Fiscal Year: 2013
  8. TGFBM2 in Development and Disease
    Rosemary J Akhurst; Fiscal Year: 2012
  9. Enhancement Of Bone Regeneration From Human Adipose-Derived Stromal Cells
    Benjamin Levi; Fiscal Year: 2010
  10. Mechanical Stimulation of Cells in Photopolymerized Gels
    Stephanie Bryant; Fiscal Year: 2009

Detail Information

Publications292 found, 100 shown here

  1. pmc Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia
    Aparna Reddy
    Fetal Medicine Unit, Elizabeth Gareth Anderson Hospital, University College Hospital, London, United Kingdom
    PLoS ONE 4:e4453. 2009
    Maternal circulating levels of anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFlt-1), endoglin (sEng) and placental proteins like activin A and inhibin A are increased before the onset of pre-eclampsia...
  2. doi Increased expression of the transforming growth factor-beta signaling pathway, endoglin, and early growth response-1 in stable plaques
    Pieter T G Bot
    Department of Cardiology, AMC Amsterdam, The Netherlands
    Stroke 40:439-47. 2009
    ..b>Endoglin, an accessory transforming growth factor-beta (TGFbeta) receptor, is a modulator of TGFbeta signaling recently ..
  3. doi First-trimester serum levels of soluble endoglin and soluble fms-like tyrosine kinase-1 as first-trimester markers for late-onset preeclampsia
    Marc U Baumann
    Department of Obstetrics and Gynecology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland
    Am J Obstet Gynecol 199:266.e1-6. 2008
    The aim of this investigation was to assess soluble endoglin (sEng) and soluble fms-like tyrosine kinase-1 (sFlt1) as first-trimester serum markers to predict preeclampsia.
  4. ncbi Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain
    Barbara A Conley
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Biol Chem 279:27440-9. 2004
    Mutations in the human endoglin gene result in hereditary hemorrhagic telangiectasia type 1, a vascular disorder characterized by multisystemic vascular dysplasia, arteriovenous malformations, and focal dilatation of postcapillary venules...
  5. ncbi Endoglin structure and function: Determinants of endoglin phosphorylation by transforming growth factor-beta receptors
    Rositsa I Koleva
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Biol Chem 281:25110-23. 2006
    ..of the functional relationship between the transforming growth factor-beta (TGFbeta) receptor proteins endoglin and ALK1 is essential to the understanding of the human vascular disease, hereditary hemorrhagic telangiectasia...
  6. ncbi Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins
    Francisco Sanz-Rodriguez
    Centro de Investigaciones Biologicas, CSIC, Ramiro de Maetzu 9, 28040 Madrid, Spain
    J Biol Chem 279:32858-68. 2004
    b>Endoglin is a component of the transforming growth factor-beta receptor complex abundantly expressed at the surface of endothelial cells and plays an important role in cardiovascular development and vascular remodeling...
  7. ncbi Angiogenesis index CD105 (endoglin)/CD31 (PECAM-1) as a predictive factor for invasion and proliferation in intraductal papillary mucinous neoplasm (IPMN) of the pancreas
    Michael Tachezy
    Department of General, Visceral, and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Germany
    Histol Histopathol 25:1239-46. 2010
    ..Therefore we investigated endothelial cell marker CD31 (PECAM-1) and angiogenesis associated marker CD105 (endoglin) by immunohistochemistry.
  8. ncbi Genetic epidemiology of hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan
    Miwako Dakeishi
    Department of Hygiene, Akita University School of Medicine, Akita, Japan
    Hum Mutat 19:140-8. 2002
    ..Linkage analysis in two large families revealed a weak yet suggestive linkage to the HHT1 locus (encoding endoglin; ENG)...
  9. ncbi Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer
    Pernilla Wikstrom
    Department of Medical Biosciences, Pathology, Umea University, Umea, Sweden
    Prostate 51:268-75. 2002
    b>Endoglin, a receptor for some of the members of the transforming growth factor-beta (TGF-beta) family, is expressed on proliferating endothelial cells and has been suggested as a marker of ongoing angiogenesis...
  10. pmc Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies
    Yang Gu
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, PO Box 33932, Shreveport, Louisiana 71130, USA
    J Clin Endocrinol Metab 93:260-6. 2008
    Increased production of antiangiogenic factors soluble endoglin (sEng) and soluble fms-like tyrosine kinase receptor-1 (sFlt-1) by the placenta contributes to the pathophysiology in preeclampsia (PE).
  11. pmc Mutant endoglin in hereditary hemorrhagic telangiectasia type 1 is transiently expressed intracellularly and is not a dominant negative
    N Pece
    Division of Immunology and Cancer Research, Hospital for Sick Children, Toronto, Canada
    J Clin Invest 100:2568-79. 1997
    b>Endoglin (CD105), a component of the TGF-beta 1 receptor complex, is the target gene for the dominantly inherited vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1)...
  12. pmc Mutation study of Spanish patients with hereditary hemorrhagic telangiectasia
    Ana Fontalba
    Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu, 9, Madrid 28040, Spain
    BMC Med Genet 9:75. 2008
    Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant and age-dependent vascular disorder characterised mainly by mutations in the Endoglin (ENG) or activin receptor-like kinase-1 (ALK1, ACVRL1) genes.
  13. pmc Clinical and genetic analyses of three Korean families with hereditary hemorrhagic telangiectasia
    Mi Jung Kim
    Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea
    BMC Med Genet 12:130. 2011
    ..b>Endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1; ALK1), receptors for transforming growth factor-β (TGF-β) ..
  14. pmc Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver
    Joanna W Ho
    Centre for the Study of Liver Disease, and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, China
    World J Gastroenterol 11:176-81. 2005
    The expression pattern of endoglin (CD105) in hepatocellular carcinoma (HCC) has not been reported so far...
  15. ncbi Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study
    Meihua Piao
    Department of Pathology and Biodefense, Saga University Faculty of Medicine, Saga 849 8501, Japan
    J Atheroscler Thromb 13:82-9. 2006
    To date, the glycoprotein endoglin and its receptor complex, formed between TGFbeta and TGFbeta R-2, have been studied in tumor angiogenesis...
  16. ncbi Expression of hypoxia-inducing factor-1 alpha and endoglin in intimal hyperplasia of the middle cerebral artery of patients with Moyamoya disease
    Yasushi Takagi
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Neurosurgery 60:338-45; discussion 345. 2007
    ....
  17. ncbi Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1
    C Rius
    Department of Immunology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Blood 92:4677-90. 1998
    b>Endoglin (CD105) is a cell surface component of the transforming growth factor-beta (TGF-beta) receptor complex highly expressed by endothelial cells...
  18. ncbi Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily
    N P Barbara
    Cancer and Blood Research Program, Toronto M5G 1X8, Ontario, Canada
    J Biol Chem 274:584-94. 1999
    b>Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor (TGF)-beta1 and -beta3, and coprecipitates with the Ser/Thr kinase signaling receptor complex by affinity labeling of endothelial and leukemic cells...
  19. ncbi Defective angiogenesis in mice lacking endoglin
    D Y Li
    Program in Human Molecular Biology and Genetics, Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112 5330, USA
    Science 284:1534-7. 1999
    b>Endoglin is a transforming growth factor-beta (TGF-beta) binding protein expressed on the surface of endothelial cells...
  20. ncbi Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1
    N Pece-Barbara
    Cancer and Blood Research Programme, Hospital for Sick Children and Department of Immunology, University of Toronto, 555 University Avenue, Toronto M5G 1X8, Canada
    Hum Mol Genet 8:2171-81. 1999
    b>ENDOGLIN codes for a homodimeric membrane glycoprotein that interacts with receptors for members of the TGF-beta superfamily and is the gene mutated in the autosomal dominant vascular disorder hereditary hemorrhagic telangiectasia type 1 (..
  21. ncbi Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels
    Ester Fonsatti
    Cancer Bioimmunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientific, Aviano 33081, Italy
    Oncogene 22:6557-63. 2003
    Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy...
  22. pmc Relationship between expression of CD105 and growth factors in malignant tumors of gastrointestinal tract and its significance
    Jian Xian Yu
    Department of Pathology, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
    World J Gastroenterol 9:2866-9. 2003
    ..At the same time, we also observed the localization of TGF-beta1 and its receptor CD105 in gastric malignant tumors.
  23. ncbi Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France
    Gaetan Lesca
    Laboratoire de Genetique, Hopital Edouard Herriot, Lyon, France
    Hum Mutat 23:289-99. 2004
    ..1231C>T (p.Arg411Trp), c.1232G>C (p.Arg411Pro), and c.1232G>A (p.Arg411Gln) were found in seven, two, and one patients, respectively. Haplotype analysis was in favor of both a founder effect and a mutation hot-spot...
  24. ncbi Hereditary hemorrhagic telangiectasia: ENG and ALK-1 mutations in Dutch patients
    T G W Letteboer
    DBG Department of Medical Genetics, University Medical Center Utrecht, PO Box 85090, 3508 AB, Utrecht, The Netherlands
    Hum Genet 116:8-16. 2005
    ..Mutations in the genes encoding endoglin (ENG, chromosome 9q34) and activin A receptor type-like kinase 1 (ALK-1, also named ACVRL1, chromosome 12q13) are ..
  25. ncbi Endoglin gene insertion polymorphism not associated with aneurysmal subarachnoid hemorrhage
    Joanna Pera
    Department of Neurology, Jagiellonian University, Krakow, Poland
    J Neurosurg 102:879-81. 2005
    ..In this study the authors investigated whether this polymorphism is associated with a subarachnoid hemorrhage (SAH) caused by a ruptured IA in a Polish population...
  26. ncbi Soluble endoglin contributes to the pathogenesis of preeclampsia
    Shivalingappa Venkatesha
    Center for Vascular Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Med 12:642-9. 2006
    ..We report a novel placenta-derived soluble TGF-beta coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls ..
  27. ncbi Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype
    Aaron D Bossler
    Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania 19014, USA
    Hum Mutat 27:667-75. 2006
    ..However, when diagnosed early, the complications can usually be prevented. Mutations in two genes, Endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1 or ALK1) have been associated with HHT...
  28. ncbi Endoglin is not critical for hematopoietic stem cell engraftment and reconstitution but regulates adult erythroid development
    Jennifer L Moody
    Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University Hospital, Lund, Sweden
    Stem Cells 25:2809-19. 2007
    b>Endoglin is a transforming growth factor-beta (TGF-beta) accessory receptor recently identified as being highly expressed on long-term repopulating hematopoietic stem cells (HSC)...
  29. pmc Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC
    Nam Y Lee
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27708, USA
    J Biol Chem 283:32527-33. 2008
    ..b>Endoglin is a co-receptor predominantly expressed in endothelial cells that participates in TGFbeta-mediated signaling ..
  30. doi Endoglin (CD105) expression in the human heart throughout gestation: an immunohistochemical study
    Barresi Valeria
    Department of Human Pathology, University of Messina, Italy
    Reprod Sci 15:1018-26. 2008
    b>Endoglin is an 180 KDa protein which plays an important role in the vascular system and cardiac embryogenesis...
  31. doi Soluble endoglin and transforming growth factor-beta1 in women who subsequently developed preeclampsia
    Ji Hyae Lim
    The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women s Healthcare Center, Seoul, Korea
    Prenat Diagn 29:471-6. 2009
    This study aimed to analyze the differences of soluble endoglin (sEng) and transforming growth factor-beta1 (TGF-beta1) according to preeclamptic complications and to investigate the correlation between these factors and the clinical ..
  32. doi Structural and functional characterization of soluble endoglin receptor
    Binh Van Le
    Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 300 Chunchun dong, Suwon 440 746, Republic of Korea
    Biochem Biophys Res Commun 383:386-91. 2009
    b>Endoglin, an accessory membrane receptor of transforming growth factor-beta (TGF-beta)1, modulates the cellular response to TGF-beta via its interaction with type I and II TGF-beta receptors...
  33. doi Hereditary hemorrhagic telangiectasia: two distinct ENG deletions in one family
    W Wooderchak
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
    Clin Genet 78:484-9. 2010
    ..Mutations in endoglin (ENG) or activin A receptor type II-like 1 (ACVRL1) account for around 90% of HHT patients, 10% of those are ..
  34. doi Update on molecular diagnosis of hereditary hemorrhagic telangiectasia
    Jennifer Richards-Yutz
    Genetic Diagnostic Laboratory, Department of Genetics, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Hum Genet 128:61-77. 2010
    ..Germline mutations in two genes, endoglin (ENG) and activin receptor like kinase 1 (ACVRL1), have been implicated in this disease...
  35. doi Soluble endoglin in preeclamptic patients with or without HELLP syndrome
    Alexandre Hertig
    Institut National de la Sante et de la Recherche Medicale, Hopital Tenon, Paris, France
    Am J Obstet Gynecol 202:594.e1-4. 2010
    The pathogenesis of the HELLP (hemolysis, enzyme liver, low platelets) syndrome is unknown. Recently soluble endoglin (sEng) was identified as a cause of the appearance of schistocytes and liver pathology in an animal model of ..
  36. pmc Endoglin suppresses human prostate cancer metastasis
    Minalini Lakshman
    Department of Medicine, Northwestern University Medical School, Lurie 6 105, 303 E Superior Street, Chicago, IL 60611, USA
    Clin Exp Metastasis 28:39-53. 2011
    b>Endoglin is a transmembrane receptor that suppresses human prostate cancer (PCa) cell invasion. Small molecule therapeutics now being tested in humans can activate endoglin signaling...
  37. doi Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling
    Steffen K Meurer
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Aachen, Germany
    Cell Signal 23:683-99. 2011
    b>Endoglin is an accessory component of the TGF-β-binding receptor complex that differentially modulates TGF-β and BMP responses...
  38. doi Molecular diagnosis in hereditary hemorrhagic telangiectasia: findings in a series tested simultaneously by sequencing and deletion/duplication analysis
    J McDonald
    Department of Radiology, HHT Center Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA
    Clin Genet 79:335-44. 2011
    ..consecutive cases in which sequencing and large deletion/duplication analysis were performed simultaneously for endoglin (ENG) and activin-like receptor kinase 1 (ACVRL1)...
  39. pmc Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells
    Hongyu Tian
    Division of Medical Oncology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    EMBO J 31:3885-900. 2012
    ..specifically increase TGF-β1- and BMP-9-induced Smad1/5/8 phosphorylation via the TGF-β superfamily receptors endoglin and activin-like kinase-1 (ALK1)...
  40. pmc Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies
    Olivier Nolan-Stevaux
    Oncology Research, Amgen, South San Francisco, CA, USA
    PLoS ONE 7:e50920. 2012
    b>Endoglin (ENG), a co-receptor for several TGFβ-family cytokines, is expressed in dividing endothelial cells alongside ALK1, the ACVRL1 gene product...
  41. ncbi Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells
    S Cheifetz
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Biol Chem 267:19027-30. 1992
    b>Endoglin, a dimeric membrane glycoprotein expressed at high levels on human vascular endothelial cells, shares regions of sequence identity with betaglycan, a major binding protein for transforming growth factor-beta (TGF-beta) that co-..
  42. ncbi Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen
    P Lastres
    Centro de Investigaciones, Biologicas, C S I C, Madrid, Spain
    Eur J Immunol 22:393-7. 1992
    b>Endoglin is an endothelial homodimeric membrane antigen containing the tripeptide arginine-glycine-aspartic acid (RGD), which is a recognition motif for adhesion receptors of the integrin family...
  43. ncbi Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells
    A Gougos
    Research Institute, Hospital for Sick Children, Toronto, Canada
    J Biol Chem 265:8361-4. 1990
    b>Endoglin is a major glycoprotein of human vascular endothelium. As observed with monoclonal antibody 44G4, the distribution of endoglin is restricted to endothelial cells in all tissues except bone marrow...
  44. ncbi Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
    K A McAllister
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710
    Nat Genet 8:345-51. 1994
    ..Linkage for some families has been established to chromosome 9q33-q34. In the present study, endoglin, a transforming growth factor beta (TGF-beta) binding protein, was analysed as a candidate gene for the disorder ..
  45. ncbi Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta
    H Yamashita
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    J Biol Chem 269:1995-2001. 1994
    Human endoglin is a dimeric protein that binds transforming growth factor-beta (TGF-beta). A porcine cDNA clone for endoglin was obtained from a porcine uterus cDNA library...
  46. ncbi Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions
    T Bellon
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Eur J Immunol 23:2340-5. 1993
    b>Endoglin is an homodimeric membrane antigen with capacity to bind transforming growth factor-beta (TGF-beta) and whose expression is up-regulated on myeloid cells upon differentiation to macrophages...
  47. pmc Endoglin modulates cellular responses to TGF-beta 1
    P Lastres
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    J Cell Biol 133:1109-21. 1996
    b>Endoglin is a homodimeric membrane glycoprotein which can bind the beta 1 and beta 3 isoforms of transforming growth factor-beta (TGF-beta). We reported previously that endoglin is upregulated during monocyte differentiation...
  48. ncbi Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles
    C J Gallione
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Hum Mutat 11:286-94. 1998
    ..Two genes have been identified for HHT. Endoglin, a TGF-beta binding protein which maps to chromosome 9q3, is the gene for HHT1...
  49. ncbi Identification of hereditary hemorrhagic telangiectasia type 1 in newborns by protein expression and mutation analysis of endoglin
    U Cymerman
    Cancer and Blood Research Program, Hospital for Sick Children, Toronto, Canada
    Pediatr Res 47:24-35. 2000
    ..b>Endoglin is the gene mutated in HHT1, which is associated with a higher prevalence of pulmonary arteriovenous ..
  50. ncbi Endoglin: An accessory component of the TGF-beta-binding receptor-complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies
    E Fonsatti
    Advanced Immunotherapy Unit, Centro di Riferimento Oncologico, I R C C S, via Pedemontana Occ le 12, Aviano, Italy 33081
    J Cell Physiol 188:1-7. 2001
    b>Endoglin (CD105) is a cell membrane glycoprotein over-expressed on highly proliferating endothelial cells in culture, and on endothelial cells of angiogenetic blood vessels within benign and malignant tissues...
  51. ncbi Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II
    Mercedes Guerrero-Esteo
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Velazquez 144, Madrid 28006, Spain
    J Biol Chem 277:29197-209. 2002
    b>Endoglin is an auxiliary component of the transforming growth factor-beta (TGF-beta) receptor system, able to associate with the signaling receptor types I (TbetaRI) and II (TbetaRII) in the presence of ligand and to modulate the cellular ..
  52. ncbi Endoglin expression is regulated by transcriptional cooperation between the hypoxia and transforming growth factor-beta pathways
    Tilman Sanchez-Elsner
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Ramiro de Maeztu 9, 28040 Madrid, Spain
    J Biol Chem 277:43799-808. 2002
    b>Endoglin is a transforming growth factor-beta (TGF-beta) co-receptor expressed mainly on endothelial cells and involved in cardiovascular development, angiogenesis, and vascular remodeling...
  53. ncbi Inducible expression of human endoglin during inflammation and wound healing in vivo
    E Torsney
    Institute of Human Genetics, University of Newcastle upon Tyne, UK
    Inflamm Res 51:464-70. 2002
    Because angiogenesis and inflammation are intimately associated and endoglin is required for angiogenesis, we wished to determine whether it also plays a role in inflammation.
  54. ncbi Over expression of endoglin in human prostate cancer suppresses cell detachment, migration and invasion
    Yuequin Liu
    Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School and the Robert H Lurie Cancer Center of Northwestern University, Olson 8524, 710 N Fairbanks, Chicago, Illinois, IL 60611, USA
    Oncogene 21:8272-81. 2002
    ..We have previously shown that the endoglin gene is differently expressed during changes in prostate cell adhesion...
  55. pmc Both high intratumoral microvessel density determined using CD105 antibody and elevated plasma levels of CD105 in colorectal cancer patients correlate with poor prognosis
    C Li
    Department of Pathology, The University of Manchester, Manchester, UK
    Br J Cancer 88:1424-31. 2003
    b>CD105 and its ligand transforming growth factor beta (TGFbeta) are modulators of angiogenesis, which drives tumour growth and metastasis. Tumour microvessel density (MVD) has proven to be an important determinant of prognosis...
  56. pmc Hereditary haemorrhagic telangiectasia: a questionnaire based study to delineate the different phenotypes caused by endoglin and ALK1 mutations
    J Berg
    Department of Medical and Molecular Genetics, GKT School of Medicine, King s College London, 8th Floor, Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    J Med Genet 40:585-90. 2003
    ..Causative mutations for HHT have been identified in two genes, endoglin and ALK1, which encode proteins involved in serine-threonine kinase signalling in the endothelial cell.
  57. ncbi mRNA expression of the angiogenesis markers VEGF and CD105 (endoglin) in human breast cancer
    Francisco Gómez-Esquer
    Universidad Rey Juan Carlos, Facultad de Ciencias de la Salud, Madrid, Spain
    Anticancer Res 24:1581-5. 2004
    Both VEGF and CD105 (endoglin) have been identified as markers of tumor angiogenesis and prognosis in breast cancer. They have always been studied in this kind of tumor by means of immunological methods.
  58. ncbi Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex
    Francisco J Blanco
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    J Cell Physiol 204:574-84. 2005
    ..b>Endoglin and ALK-1 are components of the TGF-beta receptor complex, predominantly expressed in endothelial cells, and ..
  59. ncbi Hepatic manifestation is associated with ALK1 in hereditary hemorrhagic telangiectasia: identification of five novel ALK1 and one novel ENG mutations
    Heidi K A Kuehl
    Institut fuer Humangenetik, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Hum Mutat 25:320. 2005
    ..In this study, we have identified five novel ALK1 and one ENG disease-causing mutations. We conclude that hepatic manifestation in HHT patients is associated with mutations in the ALK1 gene, but rarely with ENG mutations...
  60. ncbi Novel mutations and polymorphisms in genes causing hereditary hemorrhagic telangiectasia
    Salma A Abdalla
    Cancer Research Program, The Hospital for Sick Children, and Department of Immunology, University of Toronto, Toronto, Canada M5G 1X8
    Hum Mutat 25:320-1. 2005
    Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder caused by mutations in Endoglin (ENG) or activin receptor-like kinase-1 (ALK1, ACVRL1) genes...
  61. ncbi A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia
    Mourad Toporsian
    Cancer Research Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Circ Res 96:684-92. 2005
    ..Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a vascular disorder associated with ENDOGLIN (ENG) haploinsufficiency and characterized by venous dilatations, focal loss of capillaries, and arteriovenous ..
  62. ncbi Characterization of murine S-endoglin isoform and its effects on tumor development
    Eduardo Pérez-Gómez
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Oncogene 24:4450-61. 2005
    b>Endoglin is a transmembrane glycoprotein that acts as an auxiliary receptor for transforming growth factor-beta (TGF-beta) and modulates cellular responses to this pleiotropic cytokine...
  63. ncbi High frequency of ENG and ALK1/ACVRL1 mutations in German HHT patients
    Claudia Schulte
    Department of Otolaryngology, University of Tubingen, Tubingen, Germany
    Hum Mutat 25:595. 2005
    ..Our results demonstrate the importance of ACVRL1 and ENG mutations in German HHT patients displaying mutation frequencies over 80%...
  64. ncbi A DNA sequence polymorphism in the endoglin gene is not associated with intracranial aneurysm or aneurysmal subarachnoid hemorrhage
    David G Peters
    Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK
    Cerebrovasc Dis 20:96-100. 2005
    b>Endoglin is a member of the transforming growth factor beta family of proteins and plays a central role in vascular growth and development...
  65. ncbi Mutation study of Spanish patients with hereditary hemorrhagic telangiectasia and expression analysis of Endoglin and ALK1
    Africa Fernandez-L
    Centro de Investigaciones Biologicas, Madrid, Spain
    Hum Mutat 27:295. 2006
    ..telangiectasia (HHT) is an autosomal dominant and age-dependent vascular disorder originated by mutations in Endoglin (ENG) or activin receptor-like kinase-1 (ALK1, ACVRL1) genes...
  66. ncbi Distribution of ENG and ACVRL1 (ALK1) mutations in French HHT patients
    Gaetan Lesca
    Service de Génétique Moléculaire et Médicale, Hopital Edouard Herriot, Lyon, France
    Hum Mutat 27:598. 2006
    ..Our results also emphasize the higher prevalence of large insertions/deletions in ENG and the predominance of ACVRL1 over ENG mutations...
  67. ncbi Soluble endoglin (sEng) joins the soluble fms-like tyrosine kinase (sFlt) receptor as a pre-eclampsia molecule
    Friedrich C Luft
    Franz Volhard Clinic, Medical Faculty of the Charite, HELIOS Klinikum Berlin, Max Delbruck Center for Molecular Medicine, Berlin Buch, Wiltberg Strasse 50, 13125 Berlin, Germany
    Nephrol Dial Transplant 21:3052-4. 2006
  68. ncbi Increased intrahepatic and circulating levels of endoglin, a TGF-beta1 co-receptor, in patients with chronic hepatitis C virus infection: relationship to histological and serum markers of hepatic fibrosis
    M Clemente
    Liver Research Unit, University Hospital Santa Cristina, Madrid, Spain
    J Viral Hepat 13:625-32. 2006
    b>Endoglin, a transforming growth factor (TGF)-beta1 co-receptor, has been associated with renal and cutaneous fibrosis, as overexpression of this protein has been observed in biopsies from patients with glomerulosclerosis and scleroderma, ..
  69. ncbi Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors
    Qingjun Meng
    Cardiovascular Clinical Academic Group, University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom
    J Biol Chem 281:37069-80. 2006
    b>Endoglin is a membrane-inserted protein that is preferentially synthesized in angiogenic vascular endothelial and smooth muscle cells...
  70. ncbi Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
    Laurent David
    Institut National de la Sante et de la Recherche Medicale INSERM, Equipe Mixte INSERM EMI 01 05, Grenoble, France
    Blood 109:1953-61. 2007
    ..Overexpression of endoglin increases the BMP9 response, whereas silencing of both BMPRII and ActRIIA expressions completely abolishes it...
  71. ncbi Structural model of human endoglin, a transmembrane receptor responsible for hereditary hemorrhagic telangiectasia
    Oscar Llorca
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Ramiro de Maetzu 9, 28040 Madrid, Spain
    J Mol Biol 365:694-705. 2007
    b>Endoglin is a type I membrane protein expressed as a disulphide-linked homodimer on human vascular endothelial cells whose haploinsufficiency is responsible for the dominant vascular dysplasia known as hereditary hemorrhagic ..
  72. ncbi Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia
    Jose M Lopez-Novoa
    Departamento de Fisiologia y Farmacologia, Edificio Departamental, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Nephrol Dial Transplant 22:712-4. 2007
  73. ncbi Genotype-phenotype correlations in hereditary hemorrhagic telangiectasia: data from the French-Italian HHT network
    Gaetan Lesca
    Service de Génétique Moléculaire et Médicale, Hopital Edouard Herriot, Lyon, France, and Genetica Medica, Università di Pavia and IRCCS S Matteo, Pavia, Italy
    Genet Med 9:14-22. 2007
    ..We studied the relationship between the phenotype and genotype in patients with a proven mutation in either ENG (HHT1) or ACVRL1 (HHT2).
  74. ncbi Endoglin (CD105) expression in angiogenesis of primary hepatocellular carcinomas: analysis using tissue microarrays and comparisons with CD34 and VEGF
    Yongzhong Yao
    Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital, Medical School, Nanjing University, 321 Zhongshan Road, 210008 Nanjing, P R China
    Ann Clin Lab Sci 37:39-48. 2007
    ..of tumor microvessel density (MVD) was assessed in 105 patients with HCC by immunohistochemical staining of CD105, CD34, and vascular endothelial growth factor (VEGF)...
  75. ncbi Hereditary hemorrhagic telangiectasia: clinical features in ENG and ALK1 mutation carriers
    C Sabba
    Department of Internal Medicine and Public Health, University of Bari, Bari, Italy
    J Thromb Haemost 5:1149-57. 2007
    ..The identification of a mutated ENG (HHT1) or ALK-1 (HHT2) gene now enables a genotype-phenotype correlation.
  76. pmc Endoglin inhibits prostate cancer motility via activation of the ALK2-Smad1 pathway
    C S Craft
    Division of Hematology Oncology, Department of Medicine, Northwestern University Medical School, Northwestern University and the Robert H Lurie Cancer Center of Northwestern University, Chicago, IL, USA
    Oncogene 26:7240-50. 2007
    b>Endoglin is a transforming growth factor beta (TGFbeta) superfamily auxiliary receptor. We had previously shown that it suppressed prostate cancer (PCa) cell motility, and that its expression was lost during PCa progression...
  77. ncbi The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells
    Nam Y Lee
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 282:21507-17. 2007
    ..pathways is further regulated in endothelial cells by the endothelial specific TGF-beta superfamily co-receptor, endoglin. The importance of endoglin, ALK-1, and ALK-5 in endothelial biology is underscored by the embryonic lethal ..
  78. ncbi Coculture with prostate cancer cells alters endoglin expression and attenuates transforming growth factor-beta signaling in reactive bone marrow stromal cells
    John C O'Connor
    Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA
    Mol Cancer Res 5:585-603. 2007
    ..expression in bone marrow stromal cells cocultured with prostate cancer cells and found reduced expression of endoglin, a transmembrane glycoprotein that functions as an auxiliary coreceptor for members of the transforming growth ..
  79. pmc Particular distribution and expression pattern of endoglin (CD105) in the liver of patients with hepatocellular carcinoma
    Decai Yu
    Institute of Hepatobiliary Surgery, Nanjing University, Nanjing, Jiangsu Province, PR China
    BMC Cancer 7:122. 2007
    b>Endoglin (CD105) has been considered a prognostic marker for hepatocellular carcinoma (HCC), and widely used as an appropriate targeting for antiangenesis therapy in some cancers...
  80. pmc A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for
    Roberto Romero
    Perinatology Research Branch, National Institute of Child Health and Human Development, NIH DHHS, Bethesda, MD 20892, USA
    J Matern Fetal Neonatal Med 21:9-23. 2008
    ..b>Endoglin is a protein that regulates the pro-angiogenic effects of transforming growth factor beta, and its soluble form ..
  81. doi Maternal, gestational and neonatal characteristics and maternal angiogenic factors in normotensive pregnancies
    Anne Cathrine Staff
    Department of Obstetrics and Gynaecology, Ulleval University Hospital, Oslo, Norway
    Eur J Obstet Gynecol Reprod Biol 143:29-33. 2009
    ..The aim of this study was to explore whether preeclampsia risk factors are associated with maternal angiogenic profile in normotensive pregnancies...
  82. pmc Clinical features and mutations in the ENG, ACVRL1, and SMAD4 genes in Korean patients with hereditary hemorrhagic telangiectasia
    Seung Tae Lee
    Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 24:69-76. 2009
    ..Although mutations in the endoglin (ENG) and activin A receptor type II-like 1 (ACVRL1) genes have been known to cause HHT for more than 10 yr, ..
  83. doi Endoglin in African children with Plasmodium falciparum malaria: a novel player in severe malaria pathogenesis?
    Anelia Dietmann
    Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Infect Dis 200:1842-8. 2009
    ..Transforming growth factor beta (TGF-beta) family members are important regulators of inflammation that influence malaria pathogenesis. The soluble form of the auxiliary receptor endoglin (sEng) may play a role in malaria pathogenesis.
  84. doi Allelic variations in angiogenic pathway genes are associated with preeclampsia
    Sindhu K Srinivas
    Maternal and Child Health Research Program, Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Obstet Gynecol 202:445.e1-11. 2010
    ..This study investigates the association of allelic variation in angiogenic pathway genes and preeclampsia...
  85. ncbi [Serum soluble Endoglin, plasma endothelin-1 and coagulation function in early onset severe preeclampsia with organ dysfunction]
    Li Jun Zhang
    Department of Obstetrics and Gynecology, Second Hospital, Tianjin Medical University, Tianjin 300211, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:371-4. 2010
    To investigate the expression levels of serum soluble Endoglin (sEng), plasma endothelin-1 (ET-1) and coagulation function in patients suffering from early onset severe preeclampsia with organ dysfunction, and to analyze the clinical ..
  86. doi Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma
    E Pardali
    Department of Molecular Cell Biology, Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Oncogene 30:334-45. 2011
    ..We demonstrate here that the transforming growth factor (TGF)-β co-receptor endoglin, an endothelial cell marker, is expressed by tumor cells and its expression correlates with tumor cell plasticity ..
  87. pmc Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies
    Robert W Powers
    Department of Obstetrics, Gynecology and Women s Health, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13263. 2010
    Differences in circulating concentrations of antiangiogenic factors sFlt1 and soluble endoglin (sEng) and the pro-angiogenic growth factor PlGF are reported to precede the onset of preeclampsia weeks to months in low-risk pregnant women...
  88. pmc Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts
    Erin Morris
    Medical University of South Carolina, Division of Rheumatology, Charleston, SC, USA
    J Cell Physiol 226:3340-8. 2011
    ..The goal of this study was to determine the role of endoglin/ALK1 in TGF-β/Smad1 signaling in SSc fibroblasts...
  89. pmc Endoglin regulates cancer-stromal cell interactions in prostate tumors
    Diana Romero
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    Cancer Res 71:3482-93. 2011
    b>Endoglin is an accessory receptor for TGF-β that has been implicated in prostate cancer cell detachment, migration, and invasiveness...
  90. pmc Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth
    Roselyne Castonguay
    Acceleron Pharma, Cambridge, Massachusetts 02139, USA
    J Biol Chem 286:30034-46. 2011
    b>Endoglin (CD105), a transmembrane protein of the transforming growth factor β superfamily, plays a crucial role in angiogenesis. Mutations in endoglin result in the vascular defect known as hereditary hemorrhagic telangiectasia (HHT1)...
  91. pmc Maternal plasma concentrations of angiogenic/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia
    Tinnakorn Chaiworapongsa
    Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
    J Matern Fetal Neonatal Med 24:1187-207. 2011
    To determine whether maternal plasma concentrations of placental growth factor (PlGF), soluble endoglin (sEng), soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and -2 could identify patients at risk for developing ..
  92. pmc 5'UTR mutations of ENG cause hereditary hemorrhagic telangiectasia
    Kristy Damjanovich
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
    Orphanet J Rare Dis 6:85. 2011
    ..of the patients have a mutation in the coding region of the activin A receptor type II-like 1 (ACVRL1) or Endoglin (ENG) gene...
  93. pmc Structural and functional insights into endoglin ligand recognition and binding
    Aaron Alt
    Instituto de Biomedicina de Valencia, Valencia, Spain
    PLoS ONE 7:e29948. 2012
    b>Endoglin, a type I membrane glycoprotein expressed as a disulfide-linked homodimer on human vascular endothelial cells, is a component of the transforming growth factor (TGF)-β receptor complex and is implicated in a dominant vascular ..
  94. pmc Endoglin inhibits ERK-induced c-Myc and cyclin D1 expression to impede endothelial cell proliferation
    Christopher C Pan
    Division of Pharmacology, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 424:620-3. 2012
    b>Endoglin is an endothelial-specific transforming growth factor beta (TGF-β) co-receptor essential for angiogenesis and vascular remodeling...
  95. doi Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration
    Elisa Rossi
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, Madrid, Spain
    Blood 121:403-15. 2013
    Human endoglin is an RGD-containing transmembrane glycoprotein identified in vascular endothelial cells...
  96. ncbi Prognostic significance of angiogenesis evaluated by CD105 expression compared to CD31 in 905 breast carcinomas: correlation with long-term patient outcome
    Jean Philippe Dales
    Service d Anatomie et de Cytologie Pathologiques, Hopital Nord, 13915 Marseille Cedex 20, France
    Int J Oncol 24:1197-204. 2004
    ..CD105 (endoglin) has been reported as expressed by activated endothelial cells and consequently should better reflect ..
  97. doi The loss of endoglin promotes the invasion of extravillous trophoblasts
    Yukio Mano
    Department of Obstetrics and Gynecology, Nagoya Graduate University School of Medicine, and Department of Maternal and Perinatal Medicine, Nagoya University Hospital, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Endocrinology 152:4386-94. 2011
    b>Endoglin is a coreceptor for TGF-β, which is expressed in syncytiotrophoblasts. The soluble form of endoglin (sEng) has been observed to increase in the serum of preeclamptic patients...
  98. pmc Endoplasmic reticulum quality control is involved in the mechanism of endoglin-mediated hereditary haemorrhagic telangiectasia
    Bassam R Ali
    Department of Pathology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    PLoS ONE 6:e26206. 2011
    ..In the majority of the cases reported, the condition is caused by mutations in either ACVRL1 or endoglin genes, which encode components of the TGF-beta signalling pathway...
  99. doi Assessment of the prognostic significance of endoglin (CD105) in clear cell renal cell carcinoma using automated image analysis
    William Dubinski
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada, M5S 1A8
    Hum Pathol 43:1037-43. 2012
    ..Angiogenesis has proven to be a useful prognostic indicator in different malignancies. Endoglin (CD105) is a new marker of angiogenesis found to have prognostic utility in various tumors...
  100. ncbi Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markers
    Rahmawati Minhajat
    Department of Pathology and Biodefense, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Virchows Arch 448:127-34. 2006
    ..The present study compares the expression of CD105 with that of other endothelial markers in all tissue layers during the development of colon cancer...
  101. pmc Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia
    C L Shovlin
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 61:68-79. 1997
    ..Linkage studies in four of eight families indicated an endoglin (ENG) gene mutation...

Research Grants75

  1. Isolation of novel mesenchymal stem cell subpopulations
    Buddhadeb Dawn; Fiscal Year: 2009
    ..and MSC subpopulations isolated by flow cytometry based on the expression of CD45, c-kit, Flk-1, Sca-1, CD90, and CD105. Endothelial and cardiomyogenic differentiation will be rigorously quantitated (morphology, immunocytochemistry, ..
  2. Buddhadeb Dawn; Fiscal Year: 2016
    ..data, our fundamental hypothesis states that transplantation of antigenically-defined CD45-/c-kit-/Sca- 1+/CD90+/CD105- (abbreviated as CD105-) MSC subpopulation will confer greater reparative and regenerative benefits after ..
  3. Multipotent lung mesenchymal cells in neonatal lung injury
    Marc B Hershenson; Fiscal Year: 2010
    ..The cells are positive for Stro-1, CD73, CD90, CD105 and CD166, but negative for CD34, CD45 and CD11b, suggesting that they are of stromal but not hematopoietic origin...
  4. Seyedtaghi Takyar; Fiscal Year: 2015
    ..The level of miR-1 was quantified in (CD45-, CD31+) and (CD45-, CD105+) cells separated from total lung by FACS sorting...
  5. MiR-1 is a Critical Regulator of VEGF-Induced Angiogenesis
    Seyedtaghi Takyar; Fiscal Year: 2012
    ..The level of miR-1 was quantified in (CD45-, CD31+) and (CD45-, CD105+) cells separated from total lung by FACS sorting...
  6. Nam Y Lee; Fiscal Year: 2014
    ..effects through the endothelial cell specific TGF-[unreadable] receptor complex, ALK1 (type I receptor) and endoglin (co-receptor), along with the ubiquitous type I TGF-[unreadable] receptor, ALK5, to activate the canonical Smad 1/..
  7. Mechanism and therapy for arteriovenous malformation
    Suk Paul Oh; Fiscal Year: 2013
    ..While reduced expression of either Endoglin (ENG) or Activin receptor-like kinase 1 (ALK1) has shown to be associated HHT, the precise pathogenetic ..
  8. TGFBM2 in Development and Disease
    Rosemary J Akhurst; Fiscal Year: 2012
    ..We have identified a gene that interacts with TGFB1 in mice and humans to alter vascular disease progression. Understanding how these molecules interact may ultimately help to design new or better drugs. ..
  9. Enhancement Of Bone Regeneration From Human Adipose-Derived Stromal Cells
    Benjamin Levi; Fiscal Year: 2010
    ..Preliminary studies have shown the cell surface marker CD105 to have an increased osteogenic potential in mice and this same marker will be used to identify humans cells with ..
  10. Mechanical Stimulation of Cells in Photopolymerized Gels
    Stephanie Bryant; Fiscal Year: 2009
    ..Aim 3: Incorporate degradable crosslinks into the hydrogels and examine the macroscopic tissue composition and mechanical properties as a function of loading regimes and degradation profiles. ..
  11. GENETIC ASPECTS OF PULMONARY HYPERTENSION
    Jane Morse; Fiscal Year: 2007
    ..Our clinical resources include 100 FPPH families and 5 hereditary hemorrhagic telangiectasia (HHT1) families, four have mutations in activin-like receptor 1 (ALK-1), another gene associated with PPH...
  12. HCV Strain Variation and HCC
    Andrea D Branch; Fiscal Year: 2012
    ....
  13. Hua Su; Fiscal Year: 2016
    ..We use viral-mediated focal brain VEGF stimulation of mice with either endoglin (ENG) or activin-like kinase 1 (ALK1) haploinsufficiency...
  14. Rapid Label-Free Detection of Acute Promyelocytic Leukemia
    Lydia L Sohn; Fiscal Year: 2012
    ..Senior Personnel, George Anwar, Ph.D. at UC Berkeley will lead in the software and hardware design and packaging of the device for point-of-care. ..
  15. MYELIN PROTEIN GENE EXPRESSION IN DYSMYELINATING MUTANTS
    Wendy B Macklin; Fiscal Year: 2013
    ..These studies will have impact for a number of developmental human diseases and will provide insight into how to induce remyelination in adults, in demyelinating diseases such as multiple sclerosis. ..
  16. MANDY JO SCHMELLA; Fiscal Year: 2014
    ..address significant gaps in our understanding of PE pathophysiology by focusing on improving our understanding of endoglin (ENG) pathway dysregulation in PE...
  17. Gyongyi Szabo; Fiscal Year: 2016
    ..Arthur McCullough Cleveland Clinic Dr. Laura Nagy Cleveland Clinic Dr. Craig McClain University of Louisville Dr. Mack C. Mitchell, Jr., M.D. U. T. Southwestern Medical School Dr. Gyongyi Szabo University of Massachusetts Medical School ..
  18. Preclinical Evaluation of the Adjustable Systemic-Pulmonary Artery Shunt
    MOHAMMAD WAQAR MOHIUDDIN; Fiscal Year: 2012
    ..The applicants completed a novel device to regulate blood flow for this purpose. This study will follow the recommendations from the FDA for a GLP preclinical evaluation and bring the development of this device to clinical trials. ..
  19. Positive Emotional Processing: Exploring Novel Treatment Targets in Social Phobia
    Charles Taylor; Fiscal Year: 2012
    ..The long-term goal of this research is to develop interventions that can augment existing treatment approaches in the service of enhancing treatment response and positive social functioning in refractory GSAD patients. ..
  20. Edward P Ingenito; Fiscal Year: 2016
    ..multipotent stromal cell (LMSC) from lung tissue that expresses the same surface markers (CD44, CD73, CD90, CD105) as multipotent bone marrow stromal cells and displays regenerative capacity following transplantation in mice and ..
  21. Helen Kim; Fiscal Year: 2016
    ..3, we will demonstrate that (a) genetic variants in IL1ss and TNF are predictors of new ICH after diagnosis;(b) endoglin (ENG) genotype is associated with worsened outcome after index ICH;(c) BDNF genotype is associated with worsened ..
  22. NISHI PADMAKAR SURYAVANSHI; Fiscal Year: 2015
    ..abstract_text> ..
  23. Harris H Wang; Fiscal Year: 2015
    ..To this end, the objective of this proposal is to develop an enabling technology platform, named Genome Engineering by Self-..
  24. Identifying species-specific anti-malarial Hsp90 inhibitors using genetically eng
    Luke J Whitesell; Fiscal Year: 2012
    ..falciparum in infected red blood cells, therefore new drugs that target Hsp90 may provide an excellent method to combat this deadly disease. ..
  25. DSPP signaling in dentinogenesis
    Shuo Chen; Fiscal Year: 2013
    ..3). The NH2-terminal and COOH-terminal domains bind to their receptors, integrin 26 and CD105, on cellular membrane...
  26. Role of PGE2 receptors in the aging brain after intracerebral hemorrhage
    Jian Wang; Fiscal Year: 2012
    ..Insight into these receptors may contribute to the basis for therapeutic intervention for intracerebral hemorrhage in the elderly. ..
  27. 2010 JOINT CONFERENCE OF THE ISES-ISEE, SEOUL, KOREA
    Francine Laden; Fiscal Year: 2010
    ....
  28. Fourth International Brain-Computer Interface Meeting
    Theresa M Vaughan; Fiscal Year: 2010
    ..The meeting will end with an informal breakfast plenary session...
  29. Dynamic Image Analysis of Human Embryonic Stem Cells to Monitor Pluripotency
    Rami Mangoubi; Fiscal Year: 2010
    ....
  30. Andrew D McCulloch; Fiscal Year: 2016
    ..This program trains graduate students at the interfaces between engineering, physical sciences, biological sciences and health sciences to apply modern technologies to these challenges. ..
  31. Effectiveness of Robotic Compared to Standard Prostatectomy for Prostate Cancer
    Martin G Sanda; Fiscal Year: 2010
    ..Our findings will help determine whether robots improve quality and consistency of performance in the operating room as robots are known to have accomplished in manufacturing. ..
  32. TAS::75 0849::TAS R&D-OTHER SCIENCES-ENG DEV
    ALEXANDR CHENCHIK; Fiscal Year: 2010
    ..abstract_text> ..
  33. Evaluation of Airborne Particle Emissions from Commercial Products Containing Eng
    BETSY contact SHELTON; Fiscal Year: 2010
    ....
  34. Very Low-Cost C-Scan Ultrasonic Imaging
    Karen Morgan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  35. Student and Young Researcher Travel Support for the 10th International Conference
    JOSEPH SEYMOUR; Fiscal Year: 2009
    ..PUBLIC HEALTH SIGNIFICANCE STATEMENT (provided by applicant): This project impacts public health by increasing the quality and capability of MRI for diagnostic medical applications. ..
  36. Enhancing the "Barcode" Readability of Color-Labeled Molecular Tags by Linker Eng
    Lanrong Bi; Fiscal Year: 2009
    ..This project has the potential to offer a precise and cost-effective method for large-scale mutation detection involving analysis of a large numbers of genetic polymorphisms across many individuals. ..
  37. Functional and Tissue Specific Effects of VHL Mutations
    WENDY RATHMELL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  38. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
    ..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
  39. Novel Thrombectomy Catheter for Ischemic Stroke
    GUIREN WANG; Fiscal Year: 2004
    ..This approach can also be readily extended to other thrombectomy applications such as in cardiac circulation, peripheral vasculature etc. ..
  40. Michael J Krische; Fiscal Year: 2016
    ..Z. J. Nat. Prod. 1998, 61, 1053. (3) "Chiral Drugs," Stinson, S. C. Chem. Eng. News 1998, 76 (Sept. 21), 83. (4) "The Impact of Chiral Technology on the Pharmaceutical Industry," Richards, A.; McCague, R. Chem. Ind. 1997, June 2, 422. ..
  41. A Platform for Optical Nanomachining and Nanoablation, for Biomedical Eng & Basic
    Alan J Hunt; Fiscal Year: 2010
    ..Application of this instrumentation to an even broader range of biomedical studies involving additional investigators will be actively investigated and encouraged. ..
  42. Third International BCI Meeting
    THERESA VAUGHAN; Fiscal Year: 2005
    ..abstract_text> ..
  43. NEURAL BASIS FOR DEVELOPMENT OF COORDINATED BEHAVIORS
    ANNE BEKOFF; Fiscal Year: 1990
    ..The mechanisms used in chicks are likely to be general ones, found throughout the vertebrates, including humans...
  44. EVALUATION OF THE HIV-1 SUBTYPE C ISOLATES FROM INDIA
    Nafees Ahmad; Fiscal Year: 2002
    ..The information obtained may be useful in designing vaccination strategies againts HIV-1 subtype C and in developing intervention strategies to limit its perinatal transmission. ..
  45. FOLLOWUP OF ADULTS WITH A KNOWN INFANT FEEDING HISTORY
    EKHARD ZEIGLER; Fiscal Year: 2000
    ..This is the only group with adequate records known to be available. Moreover, this is the group on which the formula manufacturers have elected to support research. ..
  46. R&D-OTHER SCIENCES-ENG DEV
    Marc Abrams; Fiscal Year: 2009
    ..abstract_text> ..
  47. 2004 Signal Transduction by Eng. Extracel. Matrices
    David Mooney; Fiscal Year: 2004
    ..A special effort will be made to use the financial support requested to facilitate the attendance and participation of women and minorities in this meeting. ..
  48. Portable C-scan Ultrasound for Rapid Vascular Access
    Karen Morgan; Fiscal Year: 2006
    ..This research is a collaborative effort between PocketSonics, Inc. and the University of Virginia Departments of Biomedical Eng. and Electrical and Computer Eng. [unreadable] [unreadable] [unreadable]..
  49. MICROMAGNETIC RESONANCE ELASTOGRAPHY
    RICHARD MAGIN; Fiscal Year: 2006
    ....
  50. Anisotropy and Nonlinearity of Cartilage Mechanics
    Gerard Ateshian; Fiscal Year: 2008
    ..abstract_text> ..
  51. NEURAL CIRCUITRY OF THE KIDNEY
    Mark Weiss; Fiscal Year: 2006
    ..abstract_text> ..
  52. CONTROL OF SPINAL LOCOMOTOR ACTIVITY BY MONOAMINES
    BRIAN NOGA; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  53. One dimensional transport equations for CE systems by asymptotic homogenization
    Sandip Ghosal; Fiscal Year: 2009
    ..The emergence of such devices would have an enormous impact on human health as they would enable biochemical analyses (such as DNA sequencing) that currently take months or years to be completed in minutes. ..
  54. Targeted Cellular Repair of Articular Cartilage
    James Dennis; Fiscal Year: 2008
    ..The long-term goal of these studies is to develop a treatment for osteoarthritis. [unreadable] [unreadable]..
  55. Molecular Determinants of Coronary Artery Disease
    Qing Wang; Fiscal Year: 2004
    ..To this end, recently, in a large pedigree with autosomal dominant CAD/MI, we identified a specific MEF2A mutation (21-bp ..
  56. Effect of hormonal contraception on bone mineral density
    Abbey Berenson; Fiscal Year: 2005
    ..Ultimately, this study will determine which women, if any, are placed at increased risk of osteopenia or osteoporosis as a result of using these hormonal contraceptives during their reproductive years. ..
  57. Targeting Placental Pathophysiology in IUGR and Preeclampsia
    Seth Guller; Fiscal Year: 2010
    ..However, we feel that despite modifications to the original research plan, our application provides an exciting and novel framework for elucidating pathways of placental damage in IUGR and PE. ..
  58. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2003
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
  59. PKD Family Kinases and Idiopathic Pulmonary Fibrosis
    Hua Tang; Fiscal Year: 2008
    ..b>End of Abstract) [unreadable] [unreadable] PUBLIC HEALTH RELEVANCE: [unreadable] [unreadable] This proposal is designed ..
  60. RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODEL
    Michael Lawton; Fiscal Year: 2004
    ..If NO and TGF-01 are involved in the radiation arteriopathy of AVMs, they might be used to enhance the efficacy of conventional stereotactic radiosurgery as part of a gene therapy for high-grade cerebral AVMs. ..
  61. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2010
    ..The hypothesis is that cardiac fibrosis will be regulated by urokinase activity and other functions of PAI-I which will be further pursued in future studies of mice expressing functional mutations of PAI-1. ..
  62. STEM-LIKE CELLS AND TUMORGENICITY IN OSTEOSARCOMA
    CHARLES JR GIBBS; Fiscal Year: 2007
    ..demonstration of the contribution of stem-like cells in the tumorigenesis of osteosarcomas and provide a foundation upon which to base large scale investigations suitable for an R01 level application [unreadable] [unreadable] [unreadable]..
  63. Biophysical Modeling of Solute Transport in Human IVD
    Weiyong Gu; Fiscal Year: 2008
    ..A plan for sharing and disseminating the theory, techniques, and data developed in this research is also included. [unreadable] [unreadable]..
  64. HIV-1 in macrophages: Role in AID's Dementia
    MARY POTASH; Fiscal Year: 2006
    ..abstract_text> ..
  65. Fibroproliferation in Bronchiolitis Obliterans Syndrome
    Vibha Lama; Fiscal Year: 2008
    ..Martinez MD, MS and Marc Peters-Golden MD, both of whom are well-funded researchers with a long track record of mentoring. ..
  66. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2007
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  67. IMMUNE MECHANISMS IN PRISTANE INDUCED LUPUS NEPHRITIS
    Westley Reeves; Fiscal Year: 2003
    ..Future studies will address the question of whether renal abnormalities similar to those induced by pristane are involved in the pathogenesis of human lupus nephritis. ..
  68. Novel Quantitative Technology for Tissue Engineering
    Chun Yuh Charles Huang; Fiscal Year: 2010
    ..In this project, a new bioreactor system will be designed and fabricated. New methods and techniques for characterizing of mechano-electrochemical properties of the engineered tissue will be developed. ..
  69. HIV pathogenesis in a model of human brain development
    MARY POTASH; Fiscal Year: 2002
    ..Ultimately, results obtained in this system can be confirmed in primary cells or by evaluation of the expression of specific gene products in the HIV-infected brain. ..
  70. Mode of virus transmission into the brain in a mouse model of HIV-infecion
    MARY POTASH; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  71. Macrophage model of the sanctuary of HIV in the brain
    MARY POTASH; Fiscal Year: 2008
    ..5) To determine whether HIV-1 infected or uninfected macrophages/microglia cells express acute or chronic response proteins in the brains of infected persons suffering had or infected persons without brain disease. ..