CD10

Summary

Gene Symbol: CD10
Description: membrane metalloendopeptidase
Alias: CALLA, CD10, CMT2T, NEP, SCA43, SFE, neprilysin, atriopeptidase, common acute lymphocytic leukemia antigen, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), membrane metallo-endopeptidase variant 1, membrane metallo-endopeptidase variant 2, neprilysin-390, neprilysin-411, neutral endopeptidase 24.11, skin fibroblast elastase
Species: human

Top Publications

  1. pmc Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions
    L D'ADAMIO
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, MA
    Proc Natl Acad Sci U S A 86:7103-7. 1989
  2. pmc NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway
    Ryan C Thompson
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 286:1675-82. 2011
  3. pmc CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung
    M A Shipp
    Department of Medicine, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 88:10662-6. 1991
  4. ncbi Neutral endopeptidase: variable expression in human lung, inactivation in lung cancer, and modulation of peptide-induced calcium flux
    A J Cohen
    Division of Pulmonary Sciences, Denver Veterans Affairs Medical Center, Colorado, USA
    Cancer Res 56:831-9. 1996
  5. ncbi Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer
    B Göhring
    Department of Urology, Martin Luther University Halle Wittenberg, Halle, Germany
    Int J Mol Med 2:409-14. 1998
  6. ncbi Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon
    C Oefner
    Pharma Preclinical Research, F Hoffmann La Roche Ltd, Basel, CH 4070, Switzerland
    J Mol Biol 296:341-9. 2000
  7. ncbi Expression of CD10 by stromal cells during colorectal tumor development
    Hitoshi Ogawa
    Department of Pathology, Tokyo Medical University, Tokyo, Japan
    Hum Pathol 33:806-11. 2002
  8. ncbi Neprilysin gene transfer reduces human amyloid pathology in transgenic mice
    Robert A Marr
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:1992-6. 2003
  9. ncbi Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain
    Nobuhisa Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 24:991-8. 2004
  10. ncbi CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression
    Nurija Bilalovic
    Department of Pathology, University Hospital Sarajevo, Bosnia and Herzegovina
    Mod Pathol 17:1251-8. 2004

Research Grants

  1. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
  2. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2012
  3. Vasopeptidases and Beta Amyloid Accumulation
    Christopher Eckman; Fiscal Year: 2009
  4. EDWARD CHARLES DEMPSEY; Fiscal Year: 2014
  5. Mark A Yorek; Fiscal Year: 2015
  6. Transgenic Mice, Inflammation &the Alzheimer Phenotype
    Marcia N Gordon; Fiscal Year: 2012
  7. Calcitonin for treating X-linked hypophosphatemia
    KARL LEONARD INSOGNA; Fiscal Year: 2012
  8. Jamary Oliveira-Filho; Fiscal Year: 2015
  9. Sakeneh Zraika; Fiscal Year: 2016
  10. Neprilysin and Peripheral Clearance of Amyloid Peptides
    Louis B Hersh; Fiscal Year: 2010

Detail Information

Publications499 found, 100 shown here

  1. pmc Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions
    L D'ADAMIO
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, MA
    Proc Natl Acad Sci U S A 86:7103-7. 1989
    The common acute lymphoblastic leukemia antigen (CALLA) is a 749-amino acid type II integral membrane protein that has been identified recently as the neutral endopeptidase 24.11 [NEP (EC 3.4.24.11)]...
  2. pmc NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway
    Ryan C Thompson
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Biol Chem 286:1675-82. 2011
    Cell-surface protein CD10 is a prognostic marker for diffuse large B-cell lymphoma (DLBCL), where high expression of CD10 is found in the germinal center B-cell (GCB) subtype and CD10 expression is low or absent in the activated B-cell (..
  3. pmc CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung
    M A Shipp
    Department of Medicine, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 88:10662-6. 1991
    ..that these malignant pulmonary neuroendocrine cells express low levels of the cell surface metalloendopeptidase CD10/neutral endopeptidase 24...
  4. ncbi Neutral endopeptidase: variable expression in human lung, inactivation in lung cancer, and modulation of peptide-induced calcium flux
    A J Cohen
    Division of Pulmonary Sciences, Denver Veterans Affairs Medical Center, Colorado, USA
    Cancer Res 56:831-9. 1996
    Neutral endopeptidase (NEP; CALLA, CD10, EC 3.4.24.11) is a cell surface endopeptidase that hydrolyses bioactive peptides, including the bombesin-like peptides, as well as other neuropeptides...
  5. ncbi Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer
    B Göhring
    Department of Urology, Martin Luther University Halle Wittenberg, Halle, Germany
    Int J Mol Med 2:409-14. 1998
    ..We describe the down-regulation of neutral endopeptidase 24.11 (NEP) protein expression in RCC of the clear cell/chromophilic type when compared with renal parenchyma, and show for ..
  6. ncbi Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon
    C Oefner
    Pharma Preclinical Research, F Hoffmann La Roche Ltd, Basel, CH 4070, Switzerland
    J Mol Biol 296:341-9. 2000
    ..Here we describe the crystal structure of the extracellular domain (residues 52-749) of human NEP complexed with the generic metalloproteinase inhibitor phosphoramidon at 2.1 A resolution...
  7. ncbi Expression of CD10 by stromal cells during colorectal tumor development
    Hitoshi Ogawa
    Department of Pathology, Tokyo Medical University, Tokyo, Japan
    Hum Pathol 33:806-11. 2002
    b>CD10 is a cell surface metalloprotease expressed by a variety of normal cell types, including lymphoid precursor cells, germinal center B lymphocytes, and some epithelial cells...
  8. ncbi Neprilysin gene transfer reduces human amyloid pathology in transgenic mice
    Robert A Marr
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:1992-6. 2003
    ..b>Neprilysin has recently been implicated as a major extracellular Abeta degrading enzyme in the brain...
  9. ncbi Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain
    Nobuhisa Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 24:991-8. 2004
    ..Here, we report on the catabolic mechanism of Abeta at the presynaptic sites. Neprilysin, an Abeta-degrading enzyme, expressed by recombinant adeno-associated viral vector-mediated gene transfer, was ..
  10. ncbi CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression
    Nurija Bilalovic
    Department of Pathology, University Hospital Sarajevo, Bosnia and Herzegovina
    Mod Pathol 17:1251-8. 2004
    b>CD10 antigen is a 100-kDa-cell surface zinc metalloendopeptidase expressed in a variety of normal and neoplastic lymphoid and nonlymphoid tissues including melanomas...
  11. ncbi Neutral endopeptidase protein expression and prognosis in localized prostate cancer
    Iman Osman
    Department of Urology, New York University Cancer Institute, Kaplan Comprehensive Cancer Center, New York, New York, USA
    Clin Cancer Res 10:4096-100. 2004
    Neutral endopeptidase (NEP) is a cell-surface peptidase that inactivates neuropeptide growth factors implicated in prostate cancer progression. The clinical significance of decreased NEP expression observed in prostate cancer is unclear...
  12. pmc Differential expression of CD10 in prostate cancer and its clinical implication
    Marc A Dall'Era
    Department of Urology, University of Washington, Seattle, WA, USA
    BMC Urol 7:3. 2007
    b>CD10 is a transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors...
  13. ncbi HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells
    Marc A Dall'Era
    Department of Urology, University of Washington, Seattle, Washington, USA
    Prostate 67:714-21. 2007
    b>CD10 is an approximately 100 kDa transmembrane metallo-endopeptidase. CD10 is strongly expressed by normal prostate epithelium. While only 30% of primary prostate tumors express CD10, it is strongly expressed by most lymph node metastases...
  14. doi Distinct subcellular expression patterns of neutral endopeptidase (CD10) in prostate cancer predict diverging clinical courses in surgically treated patients
    Achim Fleischmann
    Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 14:7838-42. 2008
    Neutral endopeptidase (CD10), an ectopeptidase bound to the cell surface, is thought to be a potential prognostic marker for prostate cancer.
  15. doi The CD10 enzyme is a key player to identify and regulate human mammary stem cells
    Elodie Bachelard-Cascales
    Universite de Lyon, Lyon, F 69007, France
    Stem Cells 28:1081-8. 2010
    ..Cells in the outer layer express CD10, a zinc-dependent metalloprotease that regulates the growth of the ductal tree during mammary gland development...
  16. pmc Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain
    Suqing Wang
    Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurochem 115:47-57. 2010
    ..The major Aβ-degrading enzymes are neprilysin (NEP), insulin-degrading enzyme (IDE), and endothelin-converting enzyme (ECE-1)...
  17. pmc Prospectively isolated cancer-associated CD10(+) fibroblasts have stronger interactions with CD133(+) colon cancer cells than with CD133(-) cancer cells
    Lin Cui
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 5:e12121. 2010
    ..colon cancer cells, with a particular focus on their interactions with cancer-associated fibroblasts, especially CD10+ fibroblasts...
  18. pmc Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses
    Naoko Morisaki
    Kao Biological Science Laboratories, 2606 Akabane, Ichikaimachi, Haga, Tochigi 321 3497, Japan
    J Biol Chem 285:39819-27. 2010
    ..As there are similarities in the molecular weights and inhibitory profiles of HSF elastase and neprilysin (neutral endopeptidase 24...
  19. doi Concise review: neutral endopeptidase (CD10): a multifaceted environment actor in stem cells, physiological mechanisms, and cancer
    Veronique Maguer-Satta
    Universite de Lyon, Lyon, F 69007, France
    Stem Cells 29:389-96. 2011
    b>CD10 is a remarkable member of the major class of widely expressed cell surface proteins, endopeptidases...
  20. doi CD10 expression in epithelial and stromal cells of non-small cell lung carcinoma (NSCLC): a clinic and pathologic correlation
    Duygu Gurel
    Department of Pathology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
    Pathol Oncol Res 18:153-60. 2012
    b>CD10 is a zinc dependent metallopeptidase, and its expression in stromal and/or epithelial cells of many carcinomas has been suggested to have prognostic value...
  21. pmc Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase 1a
    Naomasa Kakiya
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 287:29362-72. 2012
    b>Neprilysin is one of the major amyloid-β peptide (Aβ)-degrading enzymes, the expression of which declines in the brain during aging...
  22. doi Negative regulation of NEP expression by hypoxia
    Ranjana Mitra
    Cancer Research Program, Center for Diabetes and Obesity Prevention, Treatment, Research and Education, College of Pharmacy, Roseman University of Health Sciences, Henderson, NV, USA
    Prostate 73:706-14. 2013
    Neutral endopeptidase (NEP) is a transmembrane cell surface peptidase present on prostatic epithelial cells that catalytically inactivates small peptide substrates...
  23. doi Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes
    Dmitriy Mazurov
    Laboratory of Immunochemistry, Institute of Immunology, Moscow, Russia
    FEBS J 280:1200-13. 2013
    ..In this article, we describe a new partner of tetraspanin web, membrane metalloprotease CD10, which is selectively associated with CD9...
  24. ncbi CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn src-related kinase
    R K Ganju
    Department of Medicine, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 88:4159-65. 1996
    b>CD10/neutral endopeptidase 24.11 (NEP) regulates peptidemediated proliferation of lymphoid progenitors and certain epithelial cells and is itself regulated by cellular proliferation...
  25. ncbi Identification and characterization of neutral endopeptidase (EC 3. 4. 24. 11) from human prostasomes--localization in prostatic tissue and cell lines
    H Renneberg
    Department of Urology, Municipal Hospital, Offenbach, Germany
    Prostate 46:173-83. 2001
    ..The antibody as well as biochemical characteristics of the respective antigen were used to study the structural relationship of the latter with prostate membrane specific antigen (PMSA), another 100 kDa membrane protein of the prostate...
  26. ncbi Stromal expression of CD10 in invasive breast carcinoma: a new predictor of clinical outcome
    Keiichi Iwaya
    First Department of Pathology, Tokyo Medical University, 160 8402 Shinjuku 6 1 1, Shinjuku ku, Tokyo, Japan
    Virchows Arch 440:589-93. 2002
    b>CD10 is a cell surface neutral endopeptidase that is not consistently expressed in the stromal cells of the normal breast...
  27. ncbi Differential expression of the CD10 antigen (neutral endopeptidase) in primary versus metastatic malignant melanomas of the skin
    J Kanitakis
    Laboratory of Dermatopathology, Department of Dermatology, Hopital Ed Herriot, 69437 Lyon Cedex 03, France
    Melanoma Res 12:241-4. 2002
    The CD10 antigen is a neutral endopeptidase expressed by a variety of mesenchymal tumours (haemopoietic or not), including a subset of malignant melanomas...
  28. ncbi B lymphopoiesis is active throughout human life, but there are developmental age-related changes
    Maria Isabel D Rossi
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Blood 101:576-84. 2003
    ..However, sorted CD34(+) Lin(-) CD10(+) progenitors from cord blood and adult marrow had equivalent potential for differentiation in culture, and ..
  29. ncbi Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons
    Emi Hama
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 279:30259-64. 2004
    b>Neprilysin (NEP) is a rate-limiting amyloid beta peptide (Abeta)-degrading enzyme in the brain...
  30. ncbi CD10 is expressed in a subset of chromophobe renal cell carcinomas
    Guido Martignoni
    Anatomia Patologica, Universita di Sassari, Sassari, Italy
    Mod Pathol 17:1455-63. 2004
    b>CD10 has been considered a useful marker in the diagnosis of renal carcinomas, because of its expression in clear cell and papillary renal cell carcinomas and its absence in chromophobe renal cell carcinomas...
  31. ncbi CD10 expression in stromal cells of oral cavity squamous cell carcinoma: a clinic and pathologic correlation
    A Piattelli
    Dental School, University of Chieti Pescara, Chieti, Italy
    Oral Dis 12:301-4. 2006
    b>CD10 is expressed on the majority of follicle-center lymphomas and Burkitt lymphomas. CD10 has also been shown to be present in a variety of other neoplasms.
  32. ncbi Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2
    Oscar B Goodman
    Urologic Oncology Research Laboratory, Department of Urology, Weil Medical College of Cornell University New York Presbyterian Hospital, New York, NY 10021, USA
    J Biol Chem 281:33597-605. 2006
    b>Neprilysin is a cell surface peptidase that catalytically inactivates neuropeptide substrates and functions as a tumor suppressor via its enzymatic function and multiple protein-protein interactions...
  33. doi Evaluation of CD10 and procollagen 1 expression in atypical fibroxanthoma and dermatofibroma
    Sebastien de Feraudy
    Department of Pathology, University of California at San Francisco, San Francisco, CA 94115, USA
    Am J Surg Pathol 32:1111-22. 2008
    ..Procollagen 1 (PC1) and CD10 represent recently developed immunoperoxidase reagents that have been forwarded as useful in this setting, and we ..
  34. pmc Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt
    Martin Siepmann
    Department of Neurology, Molecular Cell Biology, University of Bonn, Bonn, Germany
    PLoS ONE 5:. 2010
    b>Neprilysin (NEP) is a type II membrane metalloproteinase that cleaves physiologically active peptides at the cell surface thus regulating the local concentration of these peptides available for receptor binding and signal transduction...
  35. pmc CD10 and osteopontin expression in dentigerous cyst and ameloblastoma
    Shaimaa M Masloub
    Oral Pathology Department, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
    Diagn Pathol 6:44. 2011
    To investigate the expression of CD10 and osteopontin in dentigerous cyst and ameloblastoma and to correlate their expression with neoplastic potentiality of dentigerous cyst and local invasion and risk of local recurrence in ameloblastoma...
  36. pmc Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy
    Wesley Farris
    Center for Neurologic Diseases, Department of Neurology, Harvard Institutes of Medicine, Room 730, Boston, MA 02115, USA
    Am J Pathol 171:241-51. 2007
    ..There is evidence that the Abeta-degrading protease neprilysin (NEP) is down-regulated in normal aging and LOAD...
  37. pmc Bradykinin B1 receptors in the rabbit urinary bladder: induction of responses, smooth muscle contraction, and phosphatidylinositol hydrolysis
    S K Butt
    Biomedical Sciences Division, King s College London, Chelsea
    Br J Pharmacol 114:612-7. 1995
    ..We demonstrate, for the first time, B1 receptor-coupling to phosphatidylinositol hydrolysis in an intact tissue preparation...
  38. ncbi [Renal vascular responses of bradykinin in the isolated rat kidney]
    K Bagate
    Institut de Pharmacologie, , , Strasbourg
    Arch Mal Coeur Vaiss 90:1131-4. 1997
    ....
  39. pmc Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP
    A Ben Jebria
    Laboratoire de Physiologie, , , France
    Br J Pharmacol 109:131-6. 1993
    ..intestinal peptide (VIP) was studied both in the absence and in the presence of the neutral endopeptidase (NEP) inhibitor, phosphoramidon. 2...
  40. pmc Contractile activity of big endothelin-1 on the human isolated bronchus
    C Advenier
    , , France
    Br J Pharmacol 106:883-7. 1992
    ..The contribution of the metalloproteases, neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE), in the presence or absence of the epithelium lining, by use of specific ..
  41. pmc Role of kinins in anaphylactic-induced bronchoconstriction mediated by tachykinins in guinea-pigs
    F L Ricciardolo
    Cardiovascular Research Institute, University of California San Francisco
    Br J Pharmacol 113:508-12. 1994
    ....
  42. ncbi Effect of ACE/NEP inhibition on cardiac and vascular collagen in stroke-prone spontaneously hypertensive rats
    Q Pu
    Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    Am J Hypertens 14:1067-72. 2001
    ..1 +/- 2.8 v 58.8 +/- 6.1 x 10(3) microm2/mm section, respectively, P < .05). In conclusion, in addition to being a potent antihypertensive agent, omapatrilat significantly improves cardiac and vascular fibrosis in SHRSP...
  43. ncbi [Systemic and regional hemodynamic effects of a new angiotensin converting enzyme and neutral endopeptidase mixed inhibitor, alatriopril, in the dog]
    V Richard
    VACOMED, IERMP, Laboratoire de Pharmacologie, , Saint-Etienne-du-Rouvray
    Arch Mal Coeur Vaiss 86:1275-9. 1993
    ..4.24.11; atriopeptidase), responsible for the degradation of the atrial natriuretic factor (ANF)...
  44. pmc A pharmacological study of NK1 and NK2 tachykinin receptor characteristics in the rat isolated urinary bladder
    J M Hall
    Pharmacology Group, King s College London, London
    Br J Pharmacol 107:777-84. 1992
    ....
  45. pmc Attenuation of tachykinin-induced airflow obstruction and microvascular leakage in immature airways
    K Tokuyama
    Department of Pediatrics, Gunma University School of Medicine, Maebashi, Japan
    Br J Pharmacol 108:23-9. 1993
    ..5. Phosphoramidon (2.5 mg kg-1), a neutral endopeptidase (NEP) inhibitor, significantly increased RL after 0.2 nmol kg-1 SP only in adult airways...
  46. ncbi Analgesic potency of S-acetylthiorphan after intravenous administration to mice
    D M Lambert
    Laboratory of Medicinal Chemistry, School of Pharmacy, Catholic University of Louvain, Brussels, Belgium
    Eur J Pharmacol 243:129-34. 1993
    ..The results indicated that S-acetylation of the thiol function in acetylthiorphan ensures sufficient lipophilicity to permit crossing of the blood-brain barrier and that acetylthiorphan acts via a prodrug mechanism...
  47. pmc Regulation by phosphodiesterase isoenzymes of non-adrenergic non-cholinergic contraction in guinea-pig isolated main bronchus
    D Spina
    Sackler Institute of Pulmonary Pharmacology, Department of Thoracic Medicine, King s College School of Medicine and Dentistry, London
    Br J Pharmacol 116:2334-40. 1995
    ....
  48. ncbi [Atrial natriuretic factor. Current data and future perspectives]
    J B Michel
    , Paris
    Arch Mal Coeur Vaiss 83:2111-21. 1990
    ..This approach of ANF metabolism-inhibition opens new ways on the future of ANF in cardiovascular therapeutic...
  49. ncbi The effect of substance P on proliferation and proteoglycan deposition of cells derived from rabbit intervertebral disc
    I K Ashton
    Centre for Spinal Studies, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, United Kingdom
    Spine (Phila Pa 1976) 21:421-6. 1996
    ..Further investigation is required to establish whether this might have biologic relevance in relation to the maintenance or repair of the intervertebral disc...
  50. pmc Contractile activity of endothelin precursors in the isolated gallbladder of the guinea-pig: presence of an endothelin-converting enzyme
    B Battistini
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1383-90. 1995
    ..8. Thus, a phosphoramidon-sensitive endothelin-converting enzyme (ECE), different from neutral endopeptidase (NEP; EC 24.11) and not located on the epithelium, converts big ET-1 into ET-1 in the gallbladder of the guinea-pig...
  51. ncbi Atrial natriuretic factor and hypertension. A review and metaanalysis
    A S Hollister
    University of Colorado Health Sciences Center, Department of Medicine, Denver 80262
    Am J Hypertens 4:850-65. 1991
    ..The possibility that essential hypertension is associated with inappropriately low plasma ANF levels or altered responsiveness to ANF may offer new insights into the pathogenesis and treatment of hypertension...
  52. pmc Bronchodilator and pre-protective effects of urodilatin in bovine bronchi in vitro: comparison with atrial natriuretic peptide
    J E Nally
    Institute of Biomedical and Life Sciences, Glasgow University
    Br J Pharmacol 114:1391-6. 1995
    ..68 x 1O-5 M).Associated with these actions of urodilatin was a rise in cyclic GMP levels as well as the opening of ATP-sensitive K+ and small conductance Ca2+-activated K+ channels...
  53. ncbi Inhibition of the metabolism of atrial natriuretic factor causes diuresis and natriuresis in chronic heart failure
    D B Northridge
    Department of Cardiology, Western Infirmary, Glasgow, Scotland
    Am J Hypertens 3:682-7. 1990
    ..factor (ANF) is a peptide hormone secreted by the heart that is degraded in vivo by endopeptidase 24:11 (atriopeptidase)...
  54. ncbi Renal and antihypertensive effects of neutral endopeptidase inhibition in transgenic rats with an extra renin gene
    J P Stasch
    Bayer AG, Cardiovascular and Arteriosclerosis Research, Wuppertal, Germany
    Am J Hypertens 9:795-802. 1996
    The cardiovascular consequences of neutral endopeptidase (NEP) inhibition with the NEP inhibitor ecadotril were evaluated by determining acute and long-term effects of the compound on hemodynamic, hormonal, renal, and structural ..
  55. pmc Time-dependent blockade of neurogenic plasma extravasation in dura mater by 5-HT1B/D agonists and endopeptidase 24.11
    Z Huang
    Stroke Research Laboratory, Harvard Medical School, Massachusetts General Hospital, Boston 02114
    Br J Pharmacol 108:331-5. 1993
    ..11) block the delayed extravasation response. Extravasation developing later than 45 min poststimulation was not neurogenically mediated...
  56. ncbi Improving hypertension treatment. Where should we put our efforts: new drugs, new concepts, or new management?
    J Menard
    Medical Service, Broussais Hospital, Paris, France
    Am J Hypertens 5:252S-258S. 1992
    ..For this purpose, self-blood pressure measurement and teletransmission of results to the physician will provide a major treatment advance...
  57. pmc Role of angiotensin converting enzyme in the vascular effects of an endopeptidase 24.15 inhibitor
    S E Telford
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Br J Pharmacol 114:1185-92. 1995
    ....
  58. ncbi Efficacy and safety of omapatrilat with hydrochlorothiazide for the treatment of hypertension in subjects nonresponsive to hydrochlorothiazide alone
    K Ferdinand
    Xavier University of Louisiana New Orleans, USA
    Am J Hypertens 14:788-93. 2001
    ..There were no clinically relevant changes in serum creatinine or potassium. Omapatrilat was effective and well tolerated when added to HCTZ in subjects whose blood pressure was not controlled with HCTZ alone...
  59. ncbi Urinary endothelin: a possible biological marker of renal damage
    Z A Abassi
    Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Am J Hypertens 6:1046-54. 1993
    ..In addition, enhanced urinary ET excretion has been found in several forms of renal failure, both acute and chronic, and in diabetes mellitus. Thus, urinary ET has the potential of serving as a marker for renal disease...
  60. ncbi Effects of endothelin-converting enzyme inhibitors on hemolysate-induced morphological changes and production of endothelin-1 in bovine cerebrovascular endothelial cells
    A L Kwan
    Department of Neurosurgery, Kaohsiung Medical University Hospital, Taiwan, Republic of China
    J Cardiovasc Pharmacol 36:S160-2. 2000
    ..These results suggest that suppression of ET-1 production by ECE inhibitors may prove to be efficacious for the treatment of hemolysate-induced cytotoxicity on cerebral endothelial cells...
  61. ncbi Antihypertensive effects of the neutral endopeptidase inhibitor SCH 42495 in essential hypertension
    T Ogihara
    Department of Geriatric Medicine, Osaka University Medical School, Japan
    Am J Hypertens 7:943-7. 1994
    ..80, P < .001). SCH 42495 has potent antihypertensive effect associated with an enhancement of endogenous hANP and may be clinically useful as a new class of antihypertensive drug...
  62. ncbi Inhibition of neutral endopeptidase amplifies the effects of endogenous atrial natriuretic peptide on blood pressure and fluid partition
    J P Valentin
    Division of Nephrology, San Francisco General Hospital, California 94143
    Am J Hypertens 5:88-91. 1992
    ..8 +/- 0.5%, and Hct increased by 1.0 +/- 0.4%, values very similar to those observed with vehicle alone. Inhibition of neutral endopeptidase therefore amplifies the actions of endogenous ANP on blood pressure and fluid partition...
  63. ncbi Effects of atriopeptidase inhibitor UK 79300 on left ventricular hydraulic load in patients with congestive heart failure
    E P Kromer
    , Germany
    Am J Hypertens 4:460-3. 1991
    We investigated effects of the first orally active atriopeptidase inhibitor UK 79300 (Pfizer Clinical Research, UK) on left ventricular hydraulic load in patients with congestive heart failure NYHA II and III...
  64. ncbi [Atrial natriuretic factor and cardiac insufficiency]
    M Komajda
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 85:473-7. 1992
    ..Inhibitors of the enzyme degrading the peptide, neutral endopeptidase, are under evaluation in clinical trials which are at a preliminary stage for the moment...
  65. ncbi [Drugs of the future]
    M Kamajda
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 91:1423-7. 1998
    ..However, many questions concerning drug associations and poly-therapy will be raised, leading to a revision of the strategy of treatment of cardiac failure...
  66. ncbi The atriopeptidase inhibitor UK 69,578 increases atrial natriuretic factor and causes a natriuresis in normal humans
    A G Jardine
    Medical Research Council Blood Pressure Unit, Western Infirmary, Glasgow, Scotland
    Am J Hypertens 3:661-7. 1990
    The endopeptidase EC 3.4.24.11 (atriopeptidase) degrades atrial natriuretic factor (ANF). Intravenous administration of UK 69,578 (0.025 to 10...
  67. ncbi Effects of acute and chronic blockade of neutral endopeptidase with Sch 34826 on NaCl-sensitive hypertension in spontaneously hypertensive rats
    H Jin
    Department of Medicine, University of Alabama, Birmingham
    Am J Hypertens 5:210-8. 1992
    ..The current study tested the hypothesis that chronic administration of the neutral endopeptidase (NEP) inhibitor Sch 34826 prevents NaCl sensitive hypertension in SHR-S by increasing endogenous ANP...
  68. pmc Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig trachea
    N Watson
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 109:751-9. 1993
    ..The effects of the neutral endopeptidase inhibitor (NEP), phosphoramidon, were investigated in this preparation either alone or in conjunction with sensory neuropeptide ..
  69. doi Impaired plasma B-type natriuretic peptide clearance in human septic shock
    Romain Pirracchio
    Department of Anesthesiology and Critical Care Medicine, Lariboisiere Hospital, APHP, University Paris 7 Diderot, Paris, France
    Crit Care Med 36:2542-6. 2008
    ..that high BNP levels might be related to an alteration in BNP clearance pathway, namely neutral endopeptidase (NEP) 24.11. NEP 24.11 activity was measured in septic shock and in cardiogenic shock patients...
  70. ncbi Identification and localization of a neprilysin-like activity that degrades tachykinin-related peptides in the brain of the cockroach, Leucophaea maderae, and locust, Locusta migratoria
    R Elwyn Isaac
    Molecular and Cellular Biosciences, Faculty of Biological Sciences, Miall Building, University of Leeds, Leeds, LS2 9JT, United Kingdom
    J Comp Neurol 457:57-66. 2003
    b>Neprilysin (NEP) is an endopeptidase, which has an important role in the inactivation of mammalian tachykinins...
  71. ncbi Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting enzyme inhibition
    Nicholas L M Cruden
    Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, EH16 4SB
    Hypertension 44:913-8. 2004
    Angiotensin-converting enzyme and neutral endopeptidase (EC 3.4.24.11; neprilysin) are metallopeptidases present on the endothelium that metabolize bradykinin...
  72. ncbi GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice
    Jinzhou Tian
    BUCM Neurology Centre, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
    Curr Alzheimer Res 6:118-31. 2009
    ..extracts, on Abeta levels, beta- and gamma-secretases substrate (BACE1 and PS1, respectively) associated with production of Abeta, and insulin-degrading enzyme (IDE) and neprilysin (NEP) related to degradation of Abeta in the brain.
  73. ncbi CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Histopathology 39:273-8. 2001
    The CD10 antigen is expressed in acute lymphoblastic leukaemia and follicle centre cell lymphoma...
  74. pmc Neutral endopeptidase (NEP) inhibition in rats with established pulmonary hypertension secondary to chronic hypoxia
    J S Thompson
    Department of Medicine and Pharmacology, University of Sheffield, Royal Hallamshire Hospital
    Br J Pharmacol 113:1121-6. 1994
    ..2. One route of ANP metabolism in vivo is by the action of the enzyme neutral endopeptidase (NEP)...
  75. doi Neprilysin activity in cerebrospinal fluid is associated with dementia and amyloid-β42 levels in Lewy body disease
    Walter Maetzler
    Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
    J Alzheimers Dis 22:933-8. 2010
    ..b>Neprilysin (NEP) is an Aβ-degrading protein found at presynaptic terminals and in body fluids...
  76. ncbi Angiotensin I-converting enzyme-dependent and neutral endopeptidase-dependent generation and degradation of angiotensin II contrarily modulate noradrenaline release: implications for vasopeptidase-inhibitor therapy?
    Walter Raasch
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Clinic of Schleswig Holstein, Campus Lubeck, Germany
    J Hypertens 23:1597-604. 2005
    Vasopeptidase inhibitors inhibit neutral endopeptidase (NEP) and angiotensin I-converting enzyme (ACE)...
  77. ncbi Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans
    J E Jalil
    Department of Cardiovascular Diseases, Medical School, P Catholic University of Chile, Marcoleta, Chile
    J Hum Hypertens 18:119-25. 2004
    Neutral endopeptidase (NEP) hydrolyses angiotensins (Ang) I and II and generates angiotensin-(1-7) [Ang-(1-7)]...
  78. ncbi Phosphodiesterase IV and neutral endopeptidase in airways from developing and allergen sensitized rabbits
    Gary L Larsen
    Department of Pediatrics, Division of Pediatric Pulmonary Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Pulm Pharmacol Ther 19:335-42. 2006
    Phosphodiesterase IV (PDE IV) and neutral endopeptidase (NEP) may modulate the neurally mediated nonadrenergic noncholinergic inhibitory (NANCi) response. This response is not present in normal rabbits until 2 weeks of age...
  79. pmc Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships
    Nicholas D Bland
    Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK
    BMC Evol Biol 8:16. 2008
    The neprilysin (M13) family of endopeptidases are zinc-metalloenzymes, the majority of which are type II integral membrane proteins...
  80. ncbi [Effects of Naoerkang on expressions of beta-amyloid peptide 1-42 and neprilysin in hippocampus in a rat model of Alzheimer's disease]
    Hai feng Yuan
    Department of Neurology, The Second Affiliated Hospital, Xi an Jiaotong University College of Medicine, Xi an 710004, Shaanxi Province, China
    Zhong Xi Yi Jie He Xue Bao 8:152-7. 2010
    ..the effects of Naoerkang (NEK), a compound traditional Chinese herbal medicine, on the expressions of beta-amyloid peptide 1-42 (Abeta(1-42)) and neprilysin (NEP) in hippocampal tissues in a rat model of Alzheimer's disease (AD).
  81. ncbi Inhibition of neutral endopeptidase potentiates bronchial contraction induced by immune response in guinea pigs in vitro
    H Kohrogi
    First Department of Internal Medicine, Kumamoto University Medical School, Japan
    Am Rev Respir Dis 144:636-41. 1991
    To study the role of tachykinins and neutral endopeptidase (NEP), an enzyme that degrades tachykinins, in the immune response in the airways of guinea pigs sensitized to ovalbumin (OVA), we examined the bronchial contractile response to ..
  82. ncbi Neutral endopeptidase-24.11, mu and delta opioid receptors after selective brain lesions: an autoradiographic study
    G Waksman
    Département de Chimie Organique, U 266 I N S E R M, UA 498 C N R S, Faculte de Pharmacie, Paris, France
    Brain Res 436:205-16. 1987
    The cellular localization of the rat brain neutral endopeptidase (NEP, EC 3.4.24...
  83. ncbi Modulation of functionally active endothelin-converting enzyme by chronic neutral endopeptidase inhibition in experimental atherosclerosis
    J A Grantham
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 101:1976-81. 2000
    ..Neutral endopeptidase (NEP) is a genetically distinct metallopeptidase that degrades the natriuretic peptides...
  84. pmc The anti-fibrotic effect of mycophenolic acid-induced neutral endopeptidase
    Maria Pia Dell'Oglio
    Renal, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    J Am Soc Nephrol 21:2157-68. 2010
    ..performed on five randomly selected EC-MPS patients, revealed significant upregulation of neutral endopeptidase (NEP), which is an enzyme that degrades angiotensin II...
  85. ncbi The expression and localization of neutral endopeptidase 24.11/CD10 in human gestational trophoblastic diseases
    K Ino
    Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan
    Lab Invest 80:1729-38. 2000
    Neutral endopeptidase 24.11 (NEP)/CD10 is a cell-surface peptidase that hydrolyzes various bioactive peptides...
  86. ncbi The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function
    A J Turner
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK
    Bioessays 23:261-9. 2001
    b>Neprilysin (NEP), a thermolysin-like zinc metalloendopeptidase, plays an important role in turning off peptide signalling events at the cell surface...
  87. ncbi Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases
    K Shirotani
    Laboratory for Proteolytic Neuroscience, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 276:21895-901. 2001
    ..1-42-degrading enzyme whose activity is inhibited by thiorphan and phosphoramidon in vivo, we searched for neprilysin (NEP) homologues and cloned neprilysin-like peptidase (NEPLP) alpha, NEPLP beta, and NEPLP gamma cDNAs...
  88. ncbi Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig
    A Plamboeck
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 48:1882-90. 2005
    ..Dipeptidyl peptidase IV (DPP-IV) is established as the primary inactivating enzyme, but the roles of other enzymes remain unclear...
  89. ncbi Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats
    E Kostova
    Department of Preclinical and Clinical Pharmacology and Toxicology, Medical Faculty, Skopje, Republic of Macedonia
    Bratisl Lek Listy 106:407-11. 2005
    The synergistic effects of the combined ACE and NEP inhibition is based both on the blockade of angiotensin II synthesis and degradation of vasoactive peptides and NEP substrates (ANP, arginine, endothelial cells, guanylat cyclase etc...
  90. ncbi Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy
    James Scott Miners
    Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol, United Kingdom
    J Neuropathol Exp Neurol 65:1012-21. 2006
    b>Neprilysin (NEP) degrades amyloid-beta (Abeta) and is thought to contribute to its clearance from the brain...
  91. pmc Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia
    Edward C Dempsey
    Cardiovascular Pulmonary Research Laboratory B 133, University of Colorado Denver, 12700 E 19 Ave, Aurora, CO 80046, USA
    Am J Pathol 174:782-96. 2009
    b>Neprilysin is a transmembrane metalloendopeptidase that degrades neuropeptides that are important for both growth and contraction...
  92. pmc Neprilysin-2 is an important β-amyloid degrading enzyme
    Daniel Hafez
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    Am J Pathol 178:306-12. 2011
    ..The Aβ-degrading enzyme neprilysin (NEP) is the best known target of these inhibitors...
  93. ncbi Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide
    Hanspeter S Fischer
    Division of Neurochemistry, Department of Psychiatry, Innsbruck, Austria
    J Mol Neurosci 18:129-34. 2002
    Neutral endopeptidase (EC3.4.24.11, NEP, enkephalinase) is a zinc-metalloendopeptidase, cleaving a variety of substrates like enkephalins, substance P, and bradykinin. In the brain, NEP is a key enzyme in the degradation of enkephalins...
  94. pmc Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family
    G Ghaddar
    Departement de Biochimie, Faculte de Medecine, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Biochem J 347:419-29. 2000
    Because of their roles in controlling the activity of several bio-active peptides, members of the neprilysin family of zinc metallopeptidases have been identified as putative targets for the design of therapeutic agents...
  95. ncbi Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid
    James Scott Miners
    Dementia Research Group, Institute of Clinical Neurosciences, Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Frenchay, Bristol BS16 1LE, UK
    J Neurosci Methods 167:229-36. 2008
    b>Neprilysin, a zinc-metalloendopeptidase, has important roles in the physiology and pathology of many diseases such as hypertension, cancer and Alzheimer's disease...
  96. ncbi Expression and immunolocalisation of neutral endopeptidase in prostate cancer
    Martin Albrecht
    Department of Anatomy and Cell Biology, Philipps University, Marburg, Germany
    Eur Urol 44:415-22. 2003
    Neutral Endopeptidase (NEP) is a cell surface enzyme that cleaves and inactivates neuropeptides. When present on androgen-dependent prostate cancer (PC) cells, NEP inactivates growth stimulatory neuropeptides...
  97. pmc Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation
    Sakeneh Zraika
    Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    J Biol Chem 285:18177-83. 2010
    ..b>Neprilysin is a metallopeptidase known to degrade amyloid in Alzheimer disease...
  98. ncbi Discrepant expression of neprilysin on fibroblasts in diffuse systemic sclerosis
    M Matucci-Cerinic
    Department of Medicine, University of Florence, Italy
    J Rheumatol 26:347-51. 1999
    b>Neprilysin (NEP; EC3.4.24.11) is an ectopeptidase mainly produced by fibroblasts and cleaving a large number of neuropeptides...
  99. ncbi Inhibition of neutral endopeptidase potentiates the effects of atrial natriuretic peptide on acute cyclosporin-induced nephrotoxicity
    G Capasso
    Chair of Nephrology, Second University of Naples, Naples, Italy
    Nephron 86:298-305. 2000
    ..One explanation may be the rapid breakdown of this hormone by neutral endopeptidase (NEP) which is highly active in the kidney...
  100. ncbi Alterations within the endogenous opioid system in mice with targeted deletion of the neutral endopeptidase ('enkephalinase') gene
    H S Fischer
    Division of Neurochemistry, Department of Psychiatry, A 6020, Innsbruck, Austria
    Regul Pept 96:53-8. 2000
    The biological inactivation of enkephalins by neutral endopeptidase (enkephalinase, NEP, EC3.4.24.11) represents a major mechanism for the termination of enkephalinergic signalling in brain...
  101. ncbi Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction
    Y Kamijo
    Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Life Sci 70:1-15. 2001
    To evaluate whether neutral endopeptidase (NEP) inhibitors have adverse respiratory effects, the influence of a NEP inhibitor on bradykinin (BK)-induced bronchoconstriction was investigated...

Research Grants69

  1. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..We will determine whether neutral endopeptidase (NEP), a cell surface enzyme that degrades at least 11 peptides including substance P and bradykinin, attenuates ..
  2. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..and neuroprotective properties;whereas vasopeptidase inhibitors block both ACE and neutral endopeptidase (NEP) activity...
  3. Vasopeptidases and Beta Amyloid Accumulation
    Christopher Eckman; Fiscal Year: 2009
    ..In addition, inhibitors of two other vasopeptidases, neprilysin (NEP) and endothelin-converting enzyme (ECE), are currently in preclinical and clinical development as are ..
  4. EDWARD CHARLES DEMPSEY; Fiscal Year: 2014
    ..b>Neprilysin (NEP) is a transmembrane protein with a cell surface peptidase activity that degrades select pro- and anti-..
  5. Mark A Yorek; Fiscal Year: 2015
    ..a vasopeptidase inhibitor that simultaneously blocks angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) activities, treatment for insulin resistance and vascular complications associated with obesity and type 2 ..
  6. Transgenic Mice, Inflammation &the Alzheimer Phenotype
    Marcia N Gordon; Fiscal Year: 2012
    ..b>Neprilysin is a major amyloid degrading protease, and a prime candidate for use in anti-amyloid gene therapy...
  7. Calcitonin for treating X-linked hypophosphatemia
    KARL LEONARD INSOGNA; Fiscal Year: 2012
    ..This approach, unlike conventional treatment, addresses the underlying pathophysiology in this disorder and would represent the first therapeutic advance for XLH in 30 years. ..
  8. Jamary Oliveira-Filho; Fiscal Year: 2015
    ..Biomarkers orosomucoid, neprilysin, interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) were identified as diagnostic and therapeutic ..
  9. Sakeneh Zraika; Fiscal Year: 2016
    ..b>Neprilysin (NEP) is a widely expressed plasma membrane peptidase that we have shown is increased in islets with prolonged ..
  10. Neprilysin and Peripheral Clearance of Amyloid Peptides
    Louis B Hersh; Fiscal Year: 2010
    ..We have exploited this "sink effect" by showing that the peptidase neprilysin, when expressed peripherally on leukocytes reduced amyloid beta peptide levels in the brain of a hAPP transgenic ..
  11. Somatostatin Agonist Treatment for Cognitive Aging and Dementia
    Ken A Witt; Fiscal Year: 2010
    ..Somatostatin has been shown to be decreased in humans suffering from AD and specifically regulates neuronal neprilysin activity, a potent Ab-degrading enzyme...
  12. SUBSTANCE P-MEDIATED CARDIOVASCULAR INFLAMMATION
    William Weglicki; Fiscal Year: 2009
    ..Neutral endopeptidase (NEP) is the principal proteolytic SP degrading enzyme, and alterations in NEP activity may determine the severity of SP-..
  13. Untangling Amyloid Plaques With Proteases
    Jin Moo Lee; Fiscal Year: 2010
    ..of some of these proteases in vivo have resulted in increased steady-state levels of brain A? in mice, including neprilysin (NEP), insulin-degrading enzyme (IDE), endothelin-converting enzyme (ECE)...
  14. Impaired Protein Degradation Pathways in Cardiac Proteinopathy
    Patrick M McLendon; Fiscal Year: 2013
    ..routes can affect aberrant protein aggregation in CryABR120G-based DRM: 1) PAO removal/degradation by neprilysin, a protein shown to degrade soluble oligomers in similar diseases, will impact favorably on CryABR120G ..
  15. Protein-Protein Interactions in the Biology of Beta-APP
    Dennis J Selkoe; Fiscal Year: 2012
    ..central or peripheral expression of engineered versions of two well-characterized Abeta degrading proteases - neprilysin and insulin degrading enzyme (IDE) -can safely and effectively decrease cerebral Abeta burden in mouse models of ..
  16. The role of neprilysin in pancreatic beta-cell dysfunction and death
    Sakeneh Zraika; Fiscal Year: 2013
    ..The protein neprilysin, a component ofthe renin-angiotensin system (RAS), has been shown in non-islet tissues to be upregulated with ..
  17. OZONE INDUCED AIRWAY EPITHELIAL HYPERPROLIFERATION
    CHRISTOPHER MURLAS; Fiscal Year: 1999
    DESCRIPTION: (Adapted from the applicant's abstract) It is now known that the ectoenzyme neutral endopeptidase (NEP) catabolizes various spasmogens and mitogen peptides, including endothelin and gastrin- releasing peptide (GRP), thereby ..
  18. Genetically Modified Stem Cells For Alzheimer's Disease Therapy
    Xiaofeng Xia; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stem cell therapy and Ab clearance through neprilysin (NEP) gene delivery have recently been shown to be effective treatments on mouse Alzheimer's Disease (AD) models...
  19. LXR and PPARgamma mediated Abeta clearance mechanisms
    Gary E Landreth; Fiscal Year: 2011
    ..We show that lipidated forms of ApoE facilitate the intracellular degradation of A peptides by microglia through neprilysin- dependent proteolysis...
  20. DOUGLAS HAMILTON SMITH; Fiscal Year: 2016
    ..Indeed, we have shown in preliminary data using multiple models that neprilysin, the primary Ass degrading enzyme, may have a key role in clearing Ass following injury...
  21. STEVEN EMANUEL KAHN; Fiscal Year: 2016
    ..Our recently developed data demonstrate that two proteases, neprilysin and matrix metalloproteinase-9 (MMP-9), normally produced by the islet, can limit fibril formation by IAPP...
  22. WILLIAM TZU LUNG HU; Fiscal Year: 2014
    ..ICAM-1 levels is uniquely found in 16-20% of AA, and these subjects may have impaired downstream activation of neprilysin, an Ab-degrading enzyme...
  23. Li Gan; Fiscal Year: 2014
    ..However, unlike some other Abeta degradation enzymes, such as neprilysin (NEP, an endopeptidase with optimal activity at a neutral pH), CatB truncates Abeta at the C-terminus with ..
  24. Alzheimer-Like Pathologies Following Traumatic Brain Injury in Older Individuals
    DOUGLAS HAMILTON SMITH; Fiscal Year: 2012
    ..More recently, we have identified that the A2- degrading enzyme, neprilysin, may play an important role in the emergence of plaques...
  25. Investigating the role of BDNF in the Stem Cell-mediated Restoration of Cognition
    NICHOLAS ALAN CASTELLO; Fiscal Year: 2011
    ..and whether efficacy can be improved by engineering NSCs to express an AD pathology-reducing enzyme, neprilysin. Recent stem cell-based approaches to treating Alzheimer's disease have been shown to reverse memory loss ..
  26. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
    ..Degradation of SP by the cell surface-enzyme neutral endopeptidase (NEP) and desensitization of the NK 1 R by Beta-arrestins, were found to terminate signaling by SP...
  27. NEUROPEPTIDASES AND CAROTID BODY FUNCTIONS
    Ganesh Kumar; Fiscal Year: 2000
    ..Neuropeptidases, viz., neutral endopeptidase (NEP), a soluble endopeptidase (sNEP), and endothelin converting enzyme (ECE)-like activity occur in the carotid body ..
  28. Selected Peptidases and Pulmonary Vascular Remodeling in Chronic Obstructive Pulm
    EDWARD DEMPSEY; Fiscal Year: 2009
    ..We have shown that one of these peptidases, Neprilysin (NEP), is an important determinatn of susceptability to chronic hypoxic PHTN...
  29. A screen for small molecule inhibitors of soluble Abeta oligomer assembly
    Harry LeVine; Fiscal Year: 2007
    ..with compound, will be screened with trypsin, and if positive, digested with insulin-degrading enzyme and neprilysin, proteases believed to degrade Abeta peptides in vivo...
  30. NEUTRAL PROTEASES IN LUNG CANCER
    Margaret Shipp; Fiscal Year: 1993
    CD10 (common acute lymphoblastic leukemia antigen, CALLA), originally identified as a differentiation antigen on normal and malignant lymphoid progenitors and mature polymorphonuclear leukocytes, is the zinc metalloprotease neutral ..
  31. REGULATION OF NEUTROPHIL CHEMOTAXIS IN INFLAMMATION
    RICHARD PAINTER; Fiscal Year: 1993
    ..One of these enzymes has neutral endopeptidase (NEP)-like activity while the other enzyme involved has been identified as an aminopeptidase...
  32. DESIGN OF SUICIDE INHIBITORS FR ENKEPHALINASE
    ODILE SAID NEJAD; Fiscal Year: 1991
    ..These compounds will then be evaluated for their time-dependent inactivation of enkephalinase to test the efficacy of the approach...
  33. NEUTRAL ENDOPEPTIDASE INACTIVATION IN ADVANCED PROSTATE
    David Nanus; Fiscal Year: 2005
    ..Neutral endopeptidase 24.11 (NEP, CALLA, CD10) is a cell-surface peptidase that inactivates a variety of neuropeptides implicated in prostate cancer, ..
  34. METABOLISM OF PEPTIDES BY HUMAN LUNG ENZYMES
    ERVIN ERDOS; Fiscal Year: 1993
    ..Special emphasis will be on the neutral endopeptidase 24.11 (enkephalinase or NEP) that we detected in human lung and neutrophils...
  35. The role of neprilysin in pancreatic beta-cell dysfunction and death
    Sakeneh Zraika; Fiscal Year: 2010
    ..The protein neprilysin, has been shown in non-islet tissues to be upregulated with the chronically elevated glucose and fat levels seen ..
  36. Biological Significance of Oxidized Neprilysin
    Dengshun Wang; Fiscal Year: 2007
    ..The long-term objective of this study is to understand the biological significance of oxidative modification of neprilysin on amyloid deposition in aging and Alzheimer's disease (AD)...
  37. Neprilysin and Abeta-degradation in Alzheimer's disease
    Mark Kindy; Fiscal Year: 2005
    ..Recent studies indicate that the neutral endopeptidase neprilysin plays an important role in the degradation of Abeta(1-42) in the brain...
  38. REGULATION AND FUNCTION OF ANGIOTENSIN (1-7)
    Mark Chappell; Fiscal Year: 1999
    ..converting enzyme inhibition (which attenuates renal damage) augments the renal excretion of Ang-(1-7), and neprilysin (endopeptidase 24.11) inhibition reduces the excretion of Ang-(1-7), but augments Ang I and Ang II...
  39. The Role of Vsca1 in Erectile Function
    Kelvin P Davies; Fiscal Year: 2010
    ..my group and others have shown that sialorphin is an efficient physiological antagonist of neutral endopeptidase (NEP)...
  40. Prevention of Diabetic Neuropathy with ACE Inhibitors
    Mark Yorek; Fiscal Year: 2007
    ..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of ACE inhibitor treatment in human DN. ..
  41. Alvin Y Liu; Fiscal Year: 2015
    ..Tumor heterogeneity could be attributed to multiple cancer cell types: Gleason pattern 3 vs. Gleason pattern 4;CD10- vs. CD10+...
  42. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2007
    ..The original specific aims were to determine the role of neutral metalloendopeptidase (NEP), SP receptors, and mast cells in the development of cystitis, utilizing NEP / mice, NK-1R -/ mice, and mast cell ..
  43. HUMAN LUNG NEUTRAL METALLOENDOPEPTIDASE
    Bruce Marshall; Fiscal Year: 1993
    ..A neutral metalloendopeptidase (NEP) appears to play a key role in degrading many of these peptides...
  44. Copper's Role in Brain LRP-mediated Abeta Efflux and Aging
    Rashid Deane; Fiscal Year: 2010
    ..levels by reducing its BBB clearance and 3) no significant changes in protein levels of APP, BACE, IDE, NEP or A[unreadable] putative receptors such as PgP and RAGE in brain microvessels...
  45. Genetic Determinants of Hypertensive Heart Disease in CRI
    Daniel L Dries; Fiscal Year: 2011
    ..The candidate genes of interest are: corin, furin, ANP, BNP, CNP, NPR-A, NPR-B, NPR-C, PKG-I, and NEP. We will test these hypotheses in the Chronic Renal Insufficiency Cohort (CRIC): an NIH-sponsored, multi-center, ..
  46. Coronary Dysregulation Associated with Obesity
    Christine L Oltman; Fiscal Year: 2013
    ..with type 2 diabetes and obesity, including a) degradation of CGRP due to changes in expression and/or activity of NEP b) altered expression of CGRP receptor components c) alterations in activation of downstream signaling pathways ..
  47. Steffanie A Strathdee; Fiscal Year: 2016
    ..and protective behaviors: i) injecting in shooting galleries and public spaces, ii) receptive needle sharing, iii) NEP and pharmacy attendance, iv) prevalence and incidence of overdose, HIV infection and death;4) Experiences with drug ..
  48. Impact of Lifestyle with Tumor Pathways and Microenvironment on Lymphoma Survival
    ANDREW M contact EVENS; Fiscal Year: 2010
    ..e., CD68, CD7, FOXP3, CD10, Ki67, LMO2, BCL6, BCL2, p53, and p21), 3) to investigate the association of lifestyle factors and host/tumor ..
  49. CHOICES-TEEN: A Bundled Risk Reduction Intervention for Juvenile Justice Females
    DANIELLE ELIZABETH PARRISH; Fiscal Year: 2012
    ..adapted CHOICES preconception intervention (CHOICES-TEEN) in reducing the risk of HIV, nicotine-exposed pregnancy (NEP), and alcohol-exposed pregnancy (AEP) in adolescent females on intensive community probation...
  50. LISA ANN KOHN; Fiscal Year: 2015
    ..We hypothesize that this CD34+ CD10- CD62L++ ("CD10-") lymphoid-restricted progenitor population marks the first stage of commitment by human ..
  51. Richard D Morgan; Fiscal Year: 2014
    ..In aim 6, we will use our structural information to generate rare cutting MmeI-like endonucleases for therapeutic use. ..
  52. Myoepithelial cell differentiation defects in ductal carcinoma in situ (DCIS)
    Kornelia Polyak; Fiscal Year: 2013
    ..We will isolate CD10+ subpopulations of cells from normal breast tissue of healthy women and BRCA1 mutation carriers, and from different ..
  53. RCT for Smoking Cessation in 10 Medical Schools
    Judith K Ockene; Fiscal Year: 2013
    ..abstract_text> ..
  54. Plasma AB as a Surrogate Genetic Marker for LOAD
    Steven G Younkin; Fiscal Year: 2012
    ....
  55. John C Burnett; Fiscal Year: 2016
    ..Finally, establish that CD-NP is highly resistant to protease degradation by human NEP secondary to the presence of the C-terminus of DNP...
  56. José Javier Otero; Fiscal Year: 2014
    ..Our recently developed nanochannel-based electroporation (NEP) technology meets these criteria, thus potentially making it a powerful tool for this purpose...
  57. METALLOPEPTIDES AS THERAPEUTIC AGENTS
    James A Cowan; Fiscal Year: 2010
    ..1) Design and evaluate triple-action metallodrugs that target three key cardiovascular enzymes (ACE, ECE-1 and NEP)...
  58. EFFECTIVENESS OF MULTISITE NEP IN PREVENTING HIV & HBV
    David Metzger; Fiscal Year: 2000
    ..with easy access to the existing NEPs and, 2) 250 potential exchangers-- IDUs from neighborhoods targeted for new NEP sites during the second year of study operations...
  59. Integrated, on-chip RT-MME-PCR for influenza diagnostics; Phase 1 = sample prepar
    Darrell Chandler; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. POTENTIATION OF OPIATE ANALGESIA BY ELECTROSTIMULATION
    MALCOLM SKOLNICK; Fiscal Year: 1992
    ..This correlation may enable investigation of the use of combined TE and subclinical doses of morphine in pain relief therapy...
  61. Analysis of zebrafish exocrine pancreas development
    NELSON YEE; Fiscal Year: 2006
    ..One identified mutant, no exocrine pancreas (nep), lacks immunoreactivity for the pancreatic exocrine enzyme carboxypeptidase A although the exocrine precursor ..
  62. DEVELOPMENT OF AN ERGONOMIC MANUAL WHEELCHAIR PUSHRIM
    RONALD BONINGER; Fiscal Year: 2001
    ..We designed a new ergonomic pushrim (NEP) that improves the fit of a wheelchair user's hand to the pushrim...
  63. ROLE OF ENKEPHALINASE IN REGULATING AIRWAYS
    D Borson; Fiscal Year: 1991
    ....
  64. Evaluation of a 3-Component IDU Intervention
    Michael Sweat; Fiscal Year: 2005
    ..to reduce HIV and drug-associated risks, and will include (1) immediate access to a needle exchange program (NEP), health education and access to condoms, (2) voluntary counseling and testing for HIV-1 and diagnosis and ..
  65. IMPACTS OF NEEDLE EXCHANGE PROGRAM ON IDUS HIV RISK
    Lawrence Ouellet; Fiscal Year: 2000
    ..INTENDED CONSEQUENCE: NEP users will further reduce HIV risk-related behavior, causing a decline in new cases of HIV...