CCZ1

Summary

Gene Symbol: CCZ1
Description: CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
Alias: C7orf28A, CCZ1A, CGI-43, H_DJ1163J12.2, vacuolar fusion protein CCZ1 homolog, CCZ1 vacuolar protein trafficking and biogenesis associated homolog, H_NH0577018.2
Species: human

Top Publications

  1. pmc BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor
    Andreas Gerondopoulos
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Curr Biol 22:2135-9. 2012
  2. ncbi Integral and associated lysosomal membrane proteins
    Bernd Schröder
    Institute of Physiological Chemistry, Philipps University Marburg, Karl von Frisch Strasse 1, 35032 Marburg, Germany
    Traffic 8:1676-86. 2007
  3. doi Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis
    Greg T Cantin
    Departments of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Proteome Res 7:1346-51. 2008
  4. pmc A quantitative atlas of mitotic phosphorylation
    Noah Dephoure
    Department of Cell Biology, Harvard University Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:10762-7. 2008
  5. doi Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach
    Sharon Gauci
    Biomolecular Mass Spectrometry and Proteomics Group, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Anal Chem 81:4493-501. 2009
  6. doi Lysine acetylation targets protein complexes and co-regulates major cellular functions
    Chunaram Choudhary
    Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany
    Science 325:834-40. 2009
  7. pmc Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells
    Jason M Kinchen
    Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 464:778-82. 2010
  8. doi Mutants of the Saccharomyces cerevisiae VPS genes CCZ1 and YPT7 are blocked in different stages of sporulation
    Iga Piekarska
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    Eur J Cell Biol 89:780-7. 2010

Scientific Experts

  • Jason M Kinchen
  • Andreas Gerondopoulos
  • Iga Piekarska
  • Chunaram Choudhary
  • Sharon Gauci
  • Greg T Cantin
  • Matthias Mann
  • Noah Dephoure
  • Bernd Schröder
  • Andrea Linford
  • Jin Rui Liang
  • Francis A Barr
  • Lars Langemeyer
  • Roza Kucharczyk
  • Barbara Mickowska
  • Bozenna Rempola
  • Joanna Rytka
  • Michael L Nielsen
  • Shabaz Mohammed
  • Florian Gnad
  • Chanchal Kumar
  • Michael Rehman
  • Andreas O Helbig
  • Tobias C Walther
  • Jesper V Olsen
  • Monique Slijper
  • Jeroen Krijgsveld
  • Albert J R Heck
  • Wei Yi
  • Sung Kyu Park
  • Steven P Gygi
  • Judit Villen
  • Corey E Bakalarski
  • Jiing Dwan Lee
  • Sean A Beausoleil
  • Tao Xu
  • Chunshui Zhou
  • Stephen J Elledge
  • John R Yates
  • Bingwen Lu
  • Christian Wrocklage
  • Bernd Kösters
  • Cuiping Pan
  • Helmut Schafer
  • Ralf Jäger
  • Andrej Hasilik
  • Hans Peter Elsässer

Detail Information

Publications8

  1. pmc BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor
    Andreas Gerondopoulos
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Curr Biol 22:2135-9. 2012
    ..In addition, we show that BLOC-3 can promote specific membrane recruitment of Rab32/38. BLOC-3 therefore defines a novel Rab GEF family with a specific function in the biogenesis of lysosome-related organelles...
  2. ncbi Integral and associated lysosomal membrane proteins
    Bernd Schröder
    Institute of Physiological Chemistry, Philipps University Marburg, Karl von Frisch Strasse 1, 35032 Marburg, Germany
    Traffic 8:1676-86. 2007
    ..Mol Cell Proteomics 2005;4:133-143). Here, the proteins encoded by LOC201931 (FLJ38482) and LOC51622 (C7orf28A) were expressed with an appended fluorescent tag in HeLa cells and found to be present in lysosomal organelles...
  3. doi Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis
    Greg T Cantin
    Departments of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Proteome Res 7:1346-51. 2008
    ....
  4. pmc A quantitative atlas of mitotic phosphorylation
    Noah Dephoure
    Department of Cell Biology, Harvard University Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:10762-7. 2008
    ..Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases...
  5. doi Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach
    Sharon Gauci
    Biomolecular Mass Spectrometry and Proteomics Group, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Anal Chem 81:4493-501. 2009
    ....
  6. doi Lysine acetylation targets protein complexes and co-regulates major cellular functions
    Chunaram Choudhary
    Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany
    Science 325:834-40. 2009
    ..Our data demonstrate that the regulatory scope of lysine acetylation is broad and comparable with that of other major posttranslational modifications...
  7. pmc Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells
    Jason M Kinchen
    Center for Cell Clearance, University of Virginia, Charlottesville, Virginia 22908, USA
    Nature 464:778-82. 2010
    ..Moreover, a Mon1-Ccz1 complex (but not either protein alone) could bind Rab7 and could also influence Rab7 activation, suggesting Mon1-..
  8. doi Mutants of the Saccharomyces cerevisiae VPS genes CCZ1 and YPT7 are blocked in different stages of sporulation
    Iga Piekarska
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland
    Eur J Cell Biol 89:780-7. 2010
    The CCZ1 gene is a member of the class B VPS (vacuolar protein sorting) genes and it is engaged in the last stage of delivery of multiple kinds of cargo to the yeast vacuole...