Genomes and Genes
Gene Symbol: CCR2
Description: C-C motif chemokine receptor 2
Alias: CC-CKR-2, CCR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, C-C chemokine receptor type 2, MCP-1 receptor, chemokine (C-C motif) receptor 2, monocyte chemoattractant protein 1 receptor, monocyte chemotactic protein 1 receptor
Publications142 found, 100 shown here
- Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tailsI F Charo
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141 9100
Proc Natl Acad Sci U S A 91:2752-6. 1994..The identification of the MCP-1 receptor and cloning of two distinct isoforms provide powerful tools for understanding the specificity and signaling mechanisms of this important chemokine...
- The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21B L Daugherty
Department of Inflammation Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA
Genomics 41:294-5. 1997
- Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City CohortM W Smith
Science Applications International Corp Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
Science 277:959-65. 1997..A mutation (CCR2-64I) within the first transmembrane region of the CCR2 chemokine and HIV-1 receptor gene is described that occurred ..
- Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2A M Aragay
Departamento de Biologia Molecular, Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Campus Cantoblanco, E 28049 Madrid, Spain
Proc Natl Acad Sci U S A 95:2985-90. 1998..Calcium flux responses to MCP-1 in HEK293 cells expressing the CCR2B receptor were also markedly reduced upon cotransfection with GRK2 or the homologous kinase GRK3...
- Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progressionS Mummidi
Department of Medicine, University of Texas Health Science Center at San Antonio and South Texas Veterans Health Care System, Audie L Murphy Division, 78284 7870, USA
Nat Med 4:786-93. 1998Allelic variants for the HIV-1 co-receptors chemokine receptor 5 (CCR5) and CCR2, as well as the ligand for the co-receptor CXCR4, stromal-derived factor (SDF-1), have been associated with a delay in disease progression...
- Distribution of two HIV-1-resistant polymorphisms (SDF1-3'A and CCR2-64I) in East Asian and world populations and its implication in AIDS epidemiologyB Su
Human Genetics Center, University of Texas School of Public Health, Houston, TX 77225, USA
Am J Hum Genet 65:1047-53. 1999Chemokine receptor CCR2 and stromal-derived factor (SDF-1) are involved in HIV infection and AIDS symptom onset...
- Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3'A, CCR2-641, and CCR5-delta32) in global populationsB Su
Human Genetics Center, University of Texas, Houston 77030, USA
Eur J Hum Genet 8:975-9. 2000Chemokine receptors (CCR5, CXCR4 and CCR2) have been shown to be important co-receptors for HIV infection...
- Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5P Ogilvie
Institute for Research in Biomedicine, Bellinzona, Switzerland
Blood 97:1920-4. 2001..This study shows that eotaxin also interacts with CCR2 and CCR5 and can, thus, affect the responses of monocytes, which express both receptors...
- Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarctionP Gonzalez
Genética Molecular Instituto Reina Sofía de Investigación Nefrológica, Spain
Genes Immun 2:191-5. 2001..association between myocardial infarction (MI) and two DNA-polymorphisms at the proinflammatory chemokine receptors CCR2 (I64V) and CCR5 (32 bp deletion, (Delta)ccr5), defining if these polymorphisms influence the age for the onset of ..
- Polymorphism of CCR5 affecting HIV disease progression in the Japanese populationS Kageyama
Department of Virology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
AIDS Res Hum Retroviruses 17:991-5. 2001Among several factors associated with HIV-1 disease progression, genetic polymorphism of CCR2, CCR5, and CXCR4 in HIV-1 infection has been found...
- Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 -2518 G/G genotype in CAD patientsC Szalai
Section of Molecular Immunology, Hungarian Academy of Sciences, Budapest, Hungary
Atherosclerosis 158:233-9. 2001..We investigated the role of these polymorphisms together with the chemokine SDF-1-801A and the chemokine receptors CCR2-64I and CCR5Delta32 mutations in 318 patients with coronary artery disease (CAD) referred to coronary bypass ..
- Adverse effect of the CCR5 promoter -2459A allele on HIV-1 disease progressionT B Knudsen
Clinical Research Unit, Copenhagen University Hospitals Hvidovre, Kettegaard allé 50, 2650 Hvidovre, Denmark
J Med Virol 65:441-4. 2001..Other human polymorphisms, such as the CCR2 64I and the CCR5 promoter -2459 A/G transition that has been discovered recently, have also been shown to influence ..
- Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient dataJ P Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
Ann Intern Med 135:782-95. 2001..Studies relating certain chemokine and chemokine receptor gene alleles with the outcome of HIV-1 infection have yielded inconsistent results...
- Associations of CCR5, CCR2, and stromal cell-derived factor 1 genotypes with human immunodeficiency virus disease progression in patients receiving nucleoside therapyJ L Lathey
Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
J Infect Dis 184:1402-11. 2001Genotype data for CCR5, CCR2, and stromal cell-derived factor 1 (SDF-1) were obtained from 354 human immunodeficiency virus type 1 (HIV-1)-positive subjects who were being treated with nucleosides...
- Distribution of chemokine receptor CCR2 and CCR5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progressionJianming Tang
Division of Geographic Medicine, Department of Medicine, School of Medicine, Program in Epidemiology of Infection and Immunity, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Virol 76:662-72. 2002At the CC (beta) chemokine receptor 2 (CCR2) and CCR5 loci, combinations of common single-nucleotide polymorphisms (SNPs) and a 32-bp deletion (Delta32) form nine stable haplotypes (designated A through G*2)...
- Chemokine receptor genotype is associated with diabetic nephropathy in Japanese with type 2 diabetesKunihiro Nakajima
Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
Diabetes 51:238-42. 2002..Accordingly, we evaluated the effects of these genotypes on diabetic nephropathy. CCR2 V64I and CCR5 59029 (G/A) were detected by polymerase chain reaction-restriction fragment-length polymorphism in ..
- Chemokine receptor polymorphism and risk of acute rejection in human renal transplantationReza Abdi
Renal Division, Brigham and Women s Hospital, Boston, Massachesetts, USA
J Am Soc Nephrol 13:754-8. 2002..The association of human chemokine receptor genetic variants, CCR5-Delta32, CCR5-59029-A/G, CCR2-V64I, CX3CR1-V249I, and CX3CR1-T280M, with outcome in 163 renal transplant recipients was examined here...
- Structural analysis of human CCR2b and primate CCR2b by molecular modeling and molecular dynamics simulationXiu fan Shi
Cellular and Molecular Evolutionary Key Laboratory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, PR China
J Mol Model 8:217-22. 2002b>CCR2b, a chemokine receptor for MCP-1, -2, -3, -4, plays an important role in a variety of diseases involving infection, inflammation, and/or injury, as well as being a coreceptor for HIV-1 infection...
- A Monocyte chemoattractant protein-1 (MCP-1) polymorphism and outcome after renal transplantationBernd Krüger
Klinik fur Innere Medizin II, University of Regensburg, Germany
J Am Soc Nephrol 13:2585-9. 2002..In this respect, increased expression of MCP-1 and the corresponding receptor CCR2 have been demonstrated in renal transplant rejection and coronary artery disease...
- Val64Ile polymorphism in the C-C chemokine receptor 2 is associated with reduced coronary artery calcificationAna M Valdes
GlaxoSmithKline, Stevenage, Hertfordshire, UK
Arterioscler Thromb Vasc Biol 22:1924-8. 2002..have shown that genetic disruption of monocyte chemotactic protein-1 or its receptor, the C-C chemokine receptor 2 (CCR2), inhibits atherosclerosis, but few data exist in humans to suggest that the monocyte chemotactic protein-1-CCR2 ..
- Population survey of CCR5 delta32, CCR5 m303, CCR2b 64I, and SDF1 3'A allele frequencies in indigenous Chinese healthy individuals, and in HIV-1-infected and HIV-1-uninfected individuals in HIV-1 risk groupsFu Sheng Wang
Division of Biological Engineering, Beijing Institute of Infectious Disease, Beijing Hospital of Infectious Disease, Beijing, China
J Acquir Immune Defic Syndr 32:124-30. 2003..ethnic groups the frequencies of the chemokine (SDF1 3'A) and chemokine receptors (CCR5 delta32, CCR5 m303, and CCR2b 64I) HIV-1/AIDS restriction alleles...
- Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of ageJan R Ortlepp
Medical Clinic I, University Hospital of Aachen University of Technology, Pauwelsstrasse 30, 52057 Aachen, Germany
J Mol Med (Berl) 81:363-7. 2003..Chemokines have an important role in inflammation. The CCR2 chemokine receptor mediates leukocyte chemoattraction, which is involved in the pathogenesis of coronary heart ..
- C-C chemokine receptor 2 gene polymorphism in Japanese patients with multiple sclerosisRyuji Miyagishi
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita, Sapporo 060 8638, Hokkaido, Japan
J Neuroimmunol 145:135-8. 2003C-C chemokine receptor 2 (CCR2) is a receptor for chemoattractant protein-1 (MCP-1) and associated with infiltrating lymphocytes in chronic active multiple sclerosis (MS) lesions...
- CCR5 promoter human haplogroups associated with HIV-1 disease progression in Thai injection drug usersLily Nguyen
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
AIDS 18:1327-33. 2004....
- Donor genomics influence graft events: the effect of donor polymorphisms on acute rejection and chronic allograft nephropathySteven Hoffmann
Transplantation Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA
Kidney Int 66:1686-93. 2004..We assessed polymorphisms from 244 renal allograft donors to better understand the impact of donor polymorphisms on selected transplant outcomes...
- Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's diseaseCecilia Huerta
Genética Molecular IRSIN FRIAT, Hospital Central Asturias, Oviedo 33006, Spain
Neurosci Lett 370:151-4. 2004..genes encoding chemokines MCP-1 (-2518 A/G) and RANTES (-403 A/G), and chemokine receptors 5 (CCR5, Delta32) and 2 (CCR2,V64I), were associated with the risk and/or the clinical outcome of LOAD and PD...
- Dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progressionCheryl A Winkler
Laboratory of Genomic Diversity, Division of Basic Research, SAIC Frederick, NCI, Frederick, MD, USA
J Acquir Immune Defic Syndr 37:1534-8. 2004Three haplotypes for the CCR2-CCR5 region previously have been shown to affect AIDS progression; however, it is not known if the protective and accelerating effects of the haplotypes are relatively constant throughout infection or exert ..
- Protective role of the polymorphism CCR2-64I in the progression from squamous intraepithelial lesions to invasive cervical carcinomaAna Coelho
Molecular Oncology Unit and Gynaecology, Instituto Portugues de Oncologia, Laboratórios Piso 4, R Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
Gynecol Oncol 96:760-4. 2005..The aim of this study was to explore the association of the CCR2-64I polymorphism with the risk of developing invasive cervical cancer (ICC) from squamous intraepithelial lesions (..
- Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxisYuya Terashima
Department of Molecular Preventive Medicine and Solution Oriented Research for Science and Technology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
Nat Immunol 6:827-35. 2005Ligation of the chemokine receptor CCR2 on monocytes and macrophages with its ligand CCL2 results in activation of the cascade consisting of phosphatidylinositol-3-OH kinase (PI(3)K), the small G protein Rac and lamellipodium protrusion...
- Distribution of CCR2-64I and SDF1-3'A alleles and HIV status in 7 ethnic populations of CameroonLiying Ma
Department of Pathology, New York University School of Medicine, NY 10010, USA
J Acquir Immune Defic Syndr 40:89-95. 2005..We report the allelic frequencies of the AIDS-related polymorphisms CCR2-64I, SDF1-3'A, and CCR5-Delta32 in 321 volunteers from 7 ethnic groups in Cameroon...
- Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmissionFlorian Hladik
Fred Hutchinson Cancer Research Center, Clinical Research Division, Program in Infectious Diseases, 1100 Fairview Ave N, P O Box 19024, D3 100, Seattle, WA 98109 1024, USA
J Virol 79:11677-84. 2005..they carry the chemokine receptor (CR) gene alleles CCR5 open reading frame (ORF) Delta32, CCR5 promoter -2459G, or CCR2 ORF 64I (CCR2-64I), all of which have been found to diminish HIV-1 infectivity and/or disease progression...
- Analysis of CCR5, CCR2, CX3CR1, and SDF1 polymorphisms in HIV-positive treated patients: impact on response to HAART and on peripheral T lymphocyte countsBénédicte Puissant
Laboratoire d Immunogenetique moleculaire, Universite Paul Sabatier, faculté de médecine Toulouse Rangueil, 31062 Toulouse Cedex 04, France
AIDS Res Hum Retroviruses 22:153-62. 2006..and RANTES, regulated on activation, normal T cell expressed and secreted) and chemokine-receptor genes (CCR5, CCR2, CX(3)CR1) were shown to be associated with sensitivity to HIV infection and untreated HIV disease progression, ..
- Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery diseaseStavros Apostolakis
Laboratory of Clinical Virology, Faculty of Medicine, University of Crete, Heraklion 711 10, Crete, Greece
Thromb Res 119:63-71. 2007..We investigated the effect of 5 common variations of chemokine and chemokine receptor genes (SDF1-3'A, CCR5-delta32, CCR2-64I, CX3CR1-V249I and CX3CR1-T280M) on predisposition to CAD.
- Genetic polymorphism of chemokine receptors CCR2 and CCR5 in Swedish cervical cancer patientsBiying Zheng
Department of Molecular Medicine and Surgery, Karolinska Institute, Center for Molecular Medicine and Karolinska University Hospital Solna, Stockholm, Sweden
Anticancer Res 26:3669-74. 2006..HPV) infection and cervical cancer with two DNA polymorphisms of the chemokine receptors CCR5-delta32 and CCR2-64I...
- Distribution of CCR5delta32, CCR2-64I and SDF1-3'A and plasma levels of SDF-1 in HIV-1 seronegative North IndiansRomsha Verma
Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
J Clin Virol 38:198-203. 2007..Mutations in genes encoding chemokine receptors and their ligands, viz., CCR5delta32, CCR2-64I and SDF1-3'A are implicated to have protective effects against HIV-1 infection and/or disease progression...
- Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sitesChia Lin Tsou
Gladstone Institute of Cardiovascular Disease, UCSF, San Francisco, California 94158, USA
J Clin Invest 117:902-9. 2007..Here we report that CC chemokine receptor 2 (CCR2) is highly expressed on a subpopulation of blood monocytes whose numbers are markedly decreased in CCR2(-/-) mice...
- p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cellsJesang Ko
School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
Exp Mol Med 39:129-38. 2007..We have previously demonstrated that 9CRA increases expression of chemokine receptors CCR1 and CCR2 in human monocytes...
- The influence of chemokine receptor CCR2 genotypes in the route to cervical carcinogenesisAna Coelho
Molecular Oncology Virology, Instituto Portugues de Oncologia, Porto, Portugal
Gynecol Obstet Invest 64:208-12. 2007..The aim of our study was to analyse the influence of the CCR2-64I polymorphism in the development of SIL due to its preponderant role in the cervical carcinogenesis and in the ..
- Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki diseaseW B Breunis
Emma Children s Hospital, Academic Medical Center AMC, Amsterdam, The Netherlands
Clin Exp Immunol 150:83-90. 2007..KD patients and 300 healthy Dutch Caucasian controls, common genetic variants in chemokine receptor genes CCR3, CCR2, CCR5, CX3CR1, CXCR1 and CXCR2 were analysed...
- Variants of chemokine receptor 2 and interleukin 4 receptor, but not interleukin 10 or Fas ligand, increase risk of cervical cancerEmma L Ivansson
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
Int J Cancer 121:2451-7. 2007..We did not find any association for IL-10 -592, or FasL -844, previously reported to be associated with cervical cancer in the Dutch and Chinese populations, respectively...
- Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimersDenis Sohy
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire IRIBHM, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
J Biol Chem 282:30062-9. 2007..We reported previously the existence of negative binding cooperativity between the subunits of CCR2/CCR5 heterodimers...
- CCR5 haplotypes and mother-to-child HIV transmission in MalawiBonnie R Pedersen
University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS ONE 2:e838. 2007CCR5 and CCR2 gene polymorphisms (SNPs) have been associated with protection against HIV transmission in adults and with delayed progression to AIDS...
- The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individualsKilian Rittig
Department of Endocrinology, Diabetes, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Germany
Atherosclerosis 198:338-46. 2008Monocyte-chemoattractant-protein (MCP)-1 and its receptor CCR2 have been shown to play a pivotal role in vascular inflammation and atherosclerotic plaque formation...
- Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degenerationDominiek D G Despriet
Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences KNAW, Amsterdam, The Netherlands
Invest Ophthalmol Vis Sci 49:364-71. 2008To determine whether variants in the candidate genes TLR4, CCL2, and CCR2 are associated with age-related macular degeneration (AMD).
- Association of CCR5-59029 A/G and CCR2-V64I variants with renal allograft survivalMir Davood Omrani
Department of Genetics, Uromia University of Medical Sciences, Uromia, Iran
Iran J Immunol 5:201-6. 2008..Understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies...
- C-C chemokine receptor 2 expression by circulating monocytes influences atherosclerosis in patients on chronic hemodialysisSatoshi Okumoto
Department of Molecular and Internal Medicine, Graduate School of Biomedical Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, Japan
Ther Apher Dial 13:205-12. 2009..C-C chemokine receptor 2 expression by circulating monocytes influences atherosclerosis in patients on chronic hemodialysis...
- Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2M A Garcia Lopez
Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Darwin 3, 28049 Madrid, Spain
Cell Signal 21:1748-57. 2009..not universal amongst the GPCR, however, and the precise spatial and temporal events in the internalization of the CCR2 chemokine receptor remain unknown...
- Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessmentAlan R Olzinski
Cardiovascular and Urogenital Center of Excellence in Drug Discovery, King of Prussia, PA, USA
Arterioscler Thromb Vasc Biol 30:253-9. 2010....
- Genetic variation at the CCR5/CCR2 gene cluster and risk of psoriasis and psoriatic arthritisJavier Soto-Sánchez
Dermatología II, Hospital Universitario Central de Asturias, Oviedo, Spain
Cytokine 50:114-6. 2010..Our objective was to examine the association between Ps and three polymorphisms at the chemokine receptors CCR5 and CCR2.
- The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseasesGregory Conductier
Institut de Pharmacologie Moleculaire et Cellulaire, UMR6097, Centre National de la Recherche Scientifique CNRS, 660 route des Lucioles, Valbonne, France
J Neuroimmunol 224:93-100. 2010..This review will focus on the current knowledge about one of the MCPs, CCL2, and its cognate receptor, CCR2, both expressed in physiological conditions and during neurodegenerative diseases.
- CCL2 and CCR2 variants are associated with skeletal muscle strength and change in strength with resistance trainingBrennan T Harmon
Department of Integrative Systems Biology, Research Center for Genetic Medicine, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
J Appl Physiol (1985) 109:1779-85. 2010..The present study hypothesizes that genetic variations in CCL2 and its receptor (CCR2) may help explain muscle trait variability...
- The role of the CCR2 gene polymorphism in abdominal aortic aneurysmsNurkay Katrancioglu
Department of Cardiovascular Surgery, Cumhuriyet University School of Medicine, Sivas, Turkey
Angiology 62:140-3. 2011Chronic inflammation play an important role on abdominal aortic aneurysms (AAA) formation. Chemokine receptor-2 (CCR2) is involved in regulation of the inflammatory response...
- Association between the CCR2-Val64Ile polymorphism and susceptibility to HIV-1 infection: a meta-analysisDong Lin Ding
The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
Mol Med Rep 4:181-6. 2011Several studies have investigated whether the CCR2-Val64Ile polymorphism affects susceptibility to human immune deficiency virus type-1 (HIV-1), with inconclusive results...
- CCR2 polymorphism in chronic renal failure patients requiring long-term hemodialysisIlhan Sezgin
Department of Medical Genetics, Faculty of Medicine, Cumhuriyet University, Turkey
Intern Med 50:2457-61. 2011..The CCR2 chemokine receptor mediates leukocyte chemoattraction in the initiation and amplification phase of renal ..
- CCR2 acts as scavenger for CCL2 during monocyte chemotaxisSilvia Volpe
Institute for Research in Biomedicine, Bellinzona, Switzerland
PLoS ONE 7:e37208. 2012..On the other hand agonist-induced desensitization and internalization is a general paradigm for chemokine receptors which is inconsistent with the prolonged migratory capacity...
- Impact of MCP-1 and CCR-2 gene polymorphisms on coronary artery disease susceptibilityHsiu Ling Lin
Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
Mol Biol Rep 39:9023-30. 2012..Results also revealed that subjects with at least one A allele of the V64I CCR2 gene polymorphism had significantly increased risk of CAD...
- Mechanisms of HIV entry into the CNS: increased sensitivity of HIV infected CD14+CD16+ monocytes to CCL2 and key roles of CCR2, JAM-A, and ALCAM in diapedesisDionna W Williams
Department of Pathology, The Albert Einstein College of Medicine, Bronx, New York, United States of America
PLoS ONE 8:e69270. 2013..This exuberant transmigration of HIV infected monocytes was due, at least in part, to increased CCR2 and significantly heightened sensitivity to CCL2...
- Examination of genetic effects of polymorphisms in the MCP-1 and CCR2 genes on MI in the Icelandic populationKristjana Bjarnadottir
Icelandic Heart Association, Holtasmari 1, Kopavogur, Iceland
Atherosclerosis 188:341-6. 2006Monocyte chemotactic protein-1 (MCP-1) and its receptor CCR2 may play a role in mediating atherosclerosis...
- Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosisPaul A Nyquist
Department of Anesthesiology Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Cerebrovasc Dis 28:124-30. 2009Monocyte chemoattractant protein 1 (MCP-1), acting in concert with its receptor chemokine receptor 2 (CCR2), promotes recruitment of macrophages into atherosclerotic plaque...
- Induction of MCP-1 expression in airway epithelial cells: role of CCR2 receptor in airway epithelial injuryMatthew C Lundien
Division of Pulmonary and Critical Care Medicine, Veterans Affairs Medical Center, Indiana University School of Medicine, Indianapolis 46202, USA
J Clin Immunol 22:144-52. 2002..BECs (BEAS-2B from ATCC) were utilized in this study. MCP-1 interacts with CCR2B receptor (CCR2B), resulting in cell proliferation, haptotaxis, and healing of the monolayer...
- Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infectionStephanie A Mulherin
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA
AIDS 17:377-87. 2003To examine temporal variation in the effects of CCR5-Delta32 and CCR2-64I chemokine receptor gene polymorphisms on HIV-1 disease progression.
- Chemokine and chemokine receptor gene polymorphism in Tunisian hemodialysis patients with HCV infectionLeila Ksiaa Cheikh Rouhou
Immunology Research Laboratory of Kidney Transplantation and Immunopathology Laboratoire de Recherche LR03SP01, Charles Nicolle Hospital, Tunisia
Arab J Nephrol Transplant 4:117-24. 2011..Our aim was to investigate the possibility of a significant relationship between chemokines and chemokine receptor genes polymorphisms and the spontaneous clearance or the persistence of HCV infection...
- MCP-1/CCR-2-double-deficiency severely impairs the migration of hematogenous inflammatory cells following transient cerebral ischemia in miceKatharina Schuette-Nuetgen
Department of Neurology, University of Munster, Albert Schweitzer Str 33, 48129 Munster, Germany
Exp Neurol 233:849-58. 2012..Further studies are needed to clarify whether these mechanisms of inflammatory cell recruitment might be essential for early infarct development and final infarct size and to evaluate potential therapeutic implications...
- Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cellsJ M Frade
Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus Cantoblanco, Universidad Autonoma, Madrid, Spain
J Immunol 159:5576-84. 1997We have derived anti-human CCR2-specific mAbs by immunization with synthetic peptides corresponding to CCR2 sequences presumably involved in the interaction with its ligand(s)...
- Expression of CCR2 by endothelial cells : implications for MCP-1 mediated wound injury repair and In vivo inflammatory activation of endotheliumK S Weber
Institut für Prophylaxe der Kreislaufkrankheiten, Munchen, Germany
Arterioscler Thromb Vasc Biol 19:2085-93. 1999..vein endothelial cells express mRNA and surface protein of the monocyte chemotactic protein-1 (MCP-1) receptor CCR2, which was upregulated by inflammatory cytokines...
- The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypesA L Cunningham
Centre for Virus Research, The Westmead Millennium Institute, University of Sydney, Australia
J Leukoc Biol 68:311-7. 2000..Such host-cell genetic factors may affect viral load in vivo where macrophages are the predominant target cells...
- Basophil responses to chemokines are regulated by both sequential and cooperative receptor signalingA Heinemann
Leukocyte Biology Section, Biomedical Sciences Division, Imperial College School of Medicine, South Kensington, London, United Kingdom
J Immunol 165:7224-33. 2000..Blocking mAbs to CCR2 and CCR3 demonstrated that responses to higher concentrations (>10 nM) of MCP-1 were mediated by CCR3 rather ..
- Chemokine receptor homo- or heterodimerization activates distinct signaling pathwaysM Mellado
Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma de Madrid, Campus de Cantoblanco, E 28049 Madrid, Spain
EMBO J 20:2497-507. 2001..in the chemokine response, heterodimerization is also permitted between given receptor pairs, specifically between CCR2 and CCR5...
- Effects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysisJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
AIDS 17:1631-8. 2003Among perinatally infected children, the effects of certain alleles of the CCR5 and CCR2 genes on the rate of disease progression remain unclear. We addressed the effects of CCR5-delta32 and CCR2-64I in an international meta-analysis.
- Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravisXiaoyan Zhao
Department of Medicine, Immunological Research Unit, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
Int J Mol Med 12:749-53. 2003..of human autoimmune myasthenia gravis (MG) with two DNA polymorphisms of the chemokine receptors CCR5-Delta 32 and CCR2-64I...
- CCR2-64I polymorphism and CCR5Delta32 deletion in patients with Alzheimer's diseaseDaniela Galimberti
Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
J Neurol Sci 225:79-83. 2004..Genes for their related receptors, CCR2 and CCR5, respectively, are characterized by the presence of two polymorphisms: a conservative change of a valine ..
- CCR2 genotype and disease progression in a treated population of HIV type 1-infected womenSean Philpott
Wadsworth Center, New York State Department of Health, Albany, NY, USA
Clin Infect Dis 39:861-5. 2004Both antiretroviral therapy and the human coreceptor polymorphism CCR2-V64I slow progression of human immunodeficiency virus type 1 (HIV-1) disease...
- [Genetic polymorphism of human immunodeficiency virus coreceptor CCR5Delta32 and CCR2-64I alleles in Chinese Yi Ethnic group in Sichuan]Xiao ling Deng
National Center for Sexually Transmitted Disease and Acquired Immune Deficiency Syndrome Control and Prevention, Chinese Center for Disease Centrol and Prevention, Beijing 100050, China
Zhonghua Liu Xing Bing Xue Za Zhi 25:1050-3. 2004To explore genetic polymorphisms CCR5 of HIV coreceptor and CCR2 in Chinese Yi Ethnic group in Sichuan.
- Behavioral risk exposure and host genetics of susceptibility to HIV-1 infectionSadeep Shrestha
Laboratory of Genomic Diversity, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, USA
J Infect Dis 193:16-26. 2006..The matched case-control study design with measured risk exposures provides an avenue for discovering genes involved in susceptibility to infection...
- MCP-1/CCR2-dependent loop for fibrogenesis in human peripheral CD14-positive monocytesNorihiko Sakai
Department of Gastroenterology and Nephrology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
J Leukoc Biol 79:555-63. 2006..monocyte chemoattractant protein-1 [(MCP-1)/CC chemokine ligand 2], which interacts with CC chemokine receptor 2 (CCR2). However, the mechanisms leading to fibrosis via MCP-1/CCR2 signaling in Mo remain to be investigated...
- Analysis of CC chemokine receptor 5 and 2 polymorphisms and renal transplant survivalBulent Yigit
Haydarpasa Numune Research and Educational Hospital, Renal Transplantation Unit, Istanbul, Turkey
Cell Biochem Funct 25:423-6. 2007....
- The multiple personalities of the chemokine receptor CCR7 in dendritic cellsNoelia Sanchez-Sanchez
Department of Immunology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
J Immunol 176:5153-9. 2006..Herein we discuss how this receptor may contribute to modulate the immune response by regulating different functions in DCs. Finally, we also suggest a possible mechanism whereby CCR7 may control its multiple tasks in these cells...
- Chemokine expression by astrocytes plays a role in microglia/macrophage activation and subsequent neurodegeneration in secondary progressive multiple sclerosisNaoyuki Tanuma
Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, 183 8526, Japan
Acta Neuropathol 112:195-204. 2006..protein-1 (MCP-1)/CCL2 and interferon-gamma inducible protein-10 (IP-10)/CXCL10 and their receptors, CCR2 and CXCR3, while these immunoreactivities were weak in the center, thus forming a chemokine gradient...
- Association between a genetic variation of CC chemokine receptor-2 and atopic asthmaY K Kim
Department of Life Sciences, Postech Biotech Center, Pohang University of Science and Technology, Pohang, South Korea
Allergy 62:208-9. 2007
- Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantationIrena Brabcova
Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Transplantation 84:1037-44. 2007..Because these findings have not been validated, we sought confirmatory evidence of these associations in a larger group of renal transplant recipients...
- Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretroviralsKumud K Singh
Department of Pediatrics, University of California San Diego, La Jolla, CA 92093 0672, USA
J Acquir Immune Defic Syndr 49:259-65. 2008..HIV-1 mother-to-child transmission (MTCT) remains an important route of infection in sub-Saharan Africa...
- Contribution of TNF-308A and CCL2-2518A to carotid intima-media thickness in obese mexican children and adolescentsGracia Viviana González-Enríquez
Surgical Research Division, Centro de Investigacion Biomedica de Occidente, IMSS, Guadalajara, Jalisco, Mexico
Arch Med Res 39:753-9. 2008..Among the genes studied as candidates for atherosclerosis development are those for chemokines, cytokines, and adhesion molecules because of their participation in atheroma formation through monocyte recruitment and migration...
- Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDSEfe Sezgin
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
J Acquir Immune Defic Syndr 54:343-51. 2010..evaluate the effect of host genetics on HIV-NRD, we explored validated AIDS restriction gene variants CCR5Delta32, CCR2-64I, CCR5 P1, SDF-3'A, IL-10-5'A, RANTES -403A, RANTES -28G, RANTES-In1...
- Combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis in ChineseXiao Ling Zhu
Departement of Periodontology, Peking Unviersity School and Hospital of Stomatology, Beijing, P R China
Chin J Dent Res 13:109-14. 2010to examine the possible association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis (GAgP) in the Chinese population.
- Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2BC Combadiere
Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 270:29671-5. 1995..has been reported to induce [Ca2+]i changes in cells transfected with the monocyte-selective MCP-1 receptor 2B (CC CKR2B) and competes for 125I-MCP-1 binding on CC CKR2B, suggesting that it may mediate monocyte responses to MCP-3...
- Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptorsX Gong
Intramural Research Support Program, SAIC Frederick, NCI FCRDC, Frederick, Maryland 21702, USA
J Biol Chem 272:11682-5. 1997..with C-C chemokine receptors, 125I-MCP-2 bound to human embryonic kidney 293 cells transfected with CCR1 or CCR2B, known to also bind MIP-1alpha/RANTES and MCP-1, respectively, but both shared by MCP-3...
- Structural interactions between chemokine receptors, gp120 Env and CD4H Choe
Division of Human Retrovirology, Dana Farber Cancer Institute, Harvard School of Public Health, Boston, MA, 02115, USA
Semin Immunol 10:249-57. 1998..These studies are useful for elucidating the mechanism and molecular determinants of HIV-1 entry, and of inhibitors to that entry...
- The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptorM Mellado
Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Científica Universidad Autónoma de Madrid, Spain
J Immunol 161:805-13. 1998..This MCP-1-initiated phosphorylation and association to JAK2 is also observed in CCR2B-transfected HEK293 cells...
- Tumor-driven matrix invasion by infiltrating lymphocytes: involvement of the alpha1 integrin I-domainE Ferrero
Laboratory of Tumor Immunology, Scientific Institute of San Raffaele, Milan, Italy
Eur J Immunol 28:2530-6. 1998..Collectively, these findings suggest that TC may actively recruit TIL via the release of chemotactic factors that enhance an alpha1 integrin-mediated pathway of matrix invasion...
- Polymorphism of CC chemokine receptors CCR2 and CCR5 in Crohn's diseaseH Herfarth
Department of Internal Medicine, University of Regensburg, Regensburg, Germany
Immunol Lett 77:113-7. 2001..We tested the hypothesis that CC chemokine receptors CCR2 and CCR5 might be important in the regulation of the intestinal immune response in this disease, and we speculated ..
- [Polymorphisms of chemokine receptor alleles influencing genetic susceptibility to HIV-1 infection in Mongolia population in China]Q Du
Division of Bioengineering, The 302nd Hospital of PLA, Beijing 100039, China
Zhonghua Liu Xing Bing Xue Za Zhi 21:413-6. 2000Mutant frequency and polymorphism of HIV-1 resistance CCR5-Delta32, CCR2b-64I and SDF1-3'A alleles were investigated in Chinese population from Mongolian ethnic origin.
- Distribution of HIV-1 resistance-conferring polymorphic alleles SDF-1-3'A, CCR2-64I and CCR5-Delta32 in diverse populations of Andhra Pradesh, South IndiaG V Ramana
Human Genetics Center, School of Public Health, University of Texas, P O Box 20186, Houston, TX 77225, USA
J Genet 80:137-40. 2001Polymorphic allelic variants of chemokine receptors CCR2 and CCR5, as well as of stromal-derived factor-1 SDF-1, the ligand for the chemokine receptor CXCR4, are known to have protective effects against HIV-1 infection and to be involved ..
- Chemokine receptor gene polymorphisms and risk of human T lymphotropic virus type I infection in JamaicaMichie Hisada
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
J Infect Dis 185:1351-4. 2002..Frequencies of CCR5-Delta 32, CCR2-64I, and SDF-1-3'A genotype among 116 HTLV-I-positive and 126 HTLV-I-negative persons of African descent in Jamaica ..
- Distribution of two HIV-1-resistant polymorphisms (SDF1-3'A and CCR2-64I alleles) in the Polish populationMonika Lewandowska
Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznan, Poland
J Hum Genet 47:585-9. 2002Chemokine receptors (CCR2 and CXCR4) are used as coreceptors for entry of human immunodeficiency virus (HIV) into the target cells...
- CC chemokine receptor 5 delta32 and CC chemokine receptor 2 64I polymorphisms do not influence the virologic and immunologic response to antiretroviral combination therapy in human immunodeficiency virus type 1-infected patientsFerdinand W N M Wit
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, National AIDS Therapy Evaluation Centre, 1105 AZ Amsterdam, The Netherlands
J Infect Dis 186:1726-32. 2002..The prevalence of the CCR5 delta32 polymorphism was 21% (27 of 130 subjects), and the prevalence of the CCR2 64I polymorphism was 15% (19 of 130 subjects)...
- Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infectionSimon Hellier
The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Hepatology 38:1468-76. 2003..The chemokine receptors CCR5, CCR2, and CCR3 and their ligands, RANTES, MCP-1, MCP-2, and MIP-1alpha, are involved in the immune responses and the ..
- Prevalence of alleles associated with HIV resistance in RussiaGrigory S Ryabov
Laboratory of T Lymphotropic Viruses, The D I Ivanovsky Institute of Virology, Moscow 123098, Russia
Genet Test 8:73-6. 2004Genetic polymorphisms of CCR5, CCR2, and SDF1 genes have been associated with resistance during human immunodeficiency virus type 1 (HIV-1) infection and disease progression...
- CCR5 promoter polymorphism influences the interferon response of patients with chronic hepatitis C in JapanIchiro Konishi
Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan
Intervirology 47:114-20. 2004..we explore the influence of genetic polymorphisms of chemokine and chemokine receptors such as regulated upon activation and T cell secreted (RANTES), CC chemokine receptor 5 (CCR5) and CCR2 on the outcome of interferon (IFN) monotherapy.
- Analysis of CCR5-Delta 32 and CCR2-V64I polymorphisms in a cohort of Spanish HCV patients using real-time polymerase chain reaction and fluorescence resonance energy transfer technologiesM Ruiz-Ferrer
Unidad Clínica de Genética y Reproducción, Hospitales Universitarios Virgen del Rocio, Seville, Spain
J Viral Hepat 11:319-23. 2004..The objective of the present study was to elucidate the involvement of the CCR5-Delta 32 and CCR2-V64I polymorphisms in the response to the HCV infection, as well as in the histological damage and the outcome of ..
- Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1Huanliang Liu
Department of Laboratory Medicine, University of Washington School of Medicine, 1959 N E Pacific Street, Seattle, WA 98195 8070, USA
J Infect Dis 190:1055-8. 2004..2%) than in HIV-1-seropositive individuals (0.0%; P=.012). However, the CCR5-59029A, CCR2-64I, stromal cell-derived factor (SDF)-1-3'A, RANTES (regulated on activation, normally T cell-expressed and -..
- CCR2-64I and CXCL12 3'A alleles confer a favorable prognosis to AIDS patients undergoing HAART therapyAndrew M Passam
Laboratory of Virology, Medical School, University of Crete, P O Box 1393, Heraklion 71100, Crete, Greece
J Clin Virol 34:302-9. 2005The chemokine receptor polymorphisms CCR5Delta32, CXCL12 3'A, CCR2-64I and CCR5-59029 G/A have been demonstrated to affect HIV-1 infection and progression.
- Molecular determinants of exercise-induced muscle damageMonica Hubal; Fiscal Year: 2004..Understanding these processes could lead to novel treatments for musculodystrophy and other myopathies that are characterized by muscle degradation. ..
- FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESISStephen Spector; Fiscal Year: 2005..The findings of this research will provide an improved understanding of the pathogenesis of HIV-1 infection of children and perinatal transmission, and help to develop improved treatment/prevention strategies. ..
- ADOLESCENT MEDICINE TRIALS UNIT (AMTU)Stephen Spector; Fiscal Year: 2005..The experience of our team in HIV care, clinical trials and laboratory studies, we believe, will enable our group to make a significant contribution to the success of the ATN. ..
- Pediatric ACTG Coordinating and Operations CenterStephen Spector; Fiscal Year: 2005..abstract_text> ..
- PEDIATRIC AIDS CLINICAL TRIALS GROUPStephen Spector; Fiscal Year: 2006..abstract_text> ..
- Asymmetric Dimethylarginine (ADMA), Genetic Variation, and Cardiovascular DiseaseJennifer Pai; Fiscal Year: 2008..This proposal seeks to understand the influence of ADMA on CHD risk, its mediators, and also utilize these findings to improve overall risk prediction of cardiovascular disease. [unreadable] [unreadable] [unreadable] [unreadable]..
- Molecular Epidemiology of Pancreatic CancerPaige M Bracci; Fiscal Year: 2010..Blood samples will be banked for future genetic studies and data will be pooled for greater statistical power. ..