Genomes and Genes
Gene Symbol: CCNG1
Description: cyclin G1
Alias: CCNG, cyclin-G1, cyclin-G
- Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1H R Seo
Laboratory of Radiation Effect, Korea Institute of Radiological and Medical Sciences, 215 4 Gongneung dong, Nowon Ku, Seoul 139 706, Korea
Cell Death Differ 13:1475-84. 2006Although cyclin G1 has been implicated in certain p53-related biological phenomena, other aspects of its function remain unclear...
- p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2AK Okamoto
Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
Mol Cell Biol 16:6593-602. 1996We and others previously showed that cyclin G is a transcriptional target of the p53 tumor suppressor protein. However, cellular proteins which might form a complex with cyclin G have not yet been identified...
- Increased expression of cyclin G1 in leiomyoma compared with normal myometriumWon Ki Baek
Department of Microbiology, School of Medicine, Keimyung University, Daegu, Korea
Am J Obstet Gynecol 188:634-9. 2003The purpose of this study was to detect the expression of cyclin G1 in leiomyoma and to investigate the alteration of its expression compared with normal myometrial tissue that was obtained from the same patient.
- GAK: a cyclin G associated kinase contains a tensin/auxilin-like domainY Kanaoka
Department of Molecular Genetics, Osaka University, Yamadaoka, Suita, Japan
FEBS Lett 402:73-80. 1997We have cloned a cDNA encoding a novel association partner of cyclin G by West-Western blotting. The cDNA encodes a protein that harbors a Ser/Thr protein kinase-like catalytic domain at the N-terminal...
- Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cellsC L Reimer
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 274:11022-9. 1999b>Cyclin G, a recent addition to the cyclin family, was initially identified in screens for new src kinase family members and soon thereafter by differential screening for transcriptional targets of the tumor suppressor gene, p53...
- Characterisation of human cyclin G1 and G2: DNA damage inducible genesS Bates
ABL Basic Research Program, NCI FCRDC, Frederick, Maryland 21702 1201, USA
Oncogene 13:1103-9. 1996..the role played by cyclin G as a mediator of p53 function in humans cells we have isolated full length human cyclin G1 and identified a related gene designated cyclin G2...
- Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localizationT Rivera Vargas
1 CNRS, FRE 3377, Gif sur Yvette, France 2 Univ Paris Sud, FRE 3377, Gif sur Yvette, France 3 CEA, FRE 3377, Gif sur Yvette, France
Oncogene 33:2866-75. 2014..In conclusion, a nuclear IMP-3-HNRNPM complex is important for the efficient synthesis of CCND1, D3 and G1 and for the proliferation of human cancer cells...
- The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancerYulong Shang
State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
Oncotarget 7:538-49. 2016..Moreover, miR-27b directly targets the 3' untranslated regions (3'-UTRs) of CCNG1, a well-known negative regulator of P53 stability...
- Genome-wide approach to identify risk factors for therapy-related myeloid leukemiaA Bogni
Department of Pharmaceutical Sciences, The University of Tennessee, Memphis, TN 38105 2794, USA
Leukemia 20:239-46. 2006..001). Distinguishing genes included transcription-related oncogenes (v-Myb, Pax-5), cyclins (CCNG1, CCNG2 and CCND1) and histone HIST1H4C...
- Downregulation of microRNA‑34b is responsible for the elevation of blood pressure in spontaneously hypertensive ratsFan Yang
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P R China
Mol Med Rep . 2017..tools to predict the candidate target genes of miR‑34b in the database, and consequently identified cyclin G1 (CCNG1) and cyclin‑dependent kinase 6 (CDK6) as its possible target genes...
- [Molecular cloning and tissue expression of the CCNG1 gene in sheep]Gao Lei
1 Animal Husbandry and Veterinary Institute, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi 832000, China 2 Key Labortory of sheep Breeding and Development Technology of Xinjiang Produnction and Construction Crops, Shihezi 832000, China
Yi Chuan 37:374-81. 2015The CCNG1 gene encodes cyclin G1, which is an important cell cycle regulator and has been reported to be involved in reproductive biological processes, such as oocyte maturation and granule cell proliferation in mammals...
- Effects of expression of exogenous cyclin G1 on proliferation of human endometrial carcinoma cellsFang Liu
Department of Physiology, West China School of Preclinical and Forensic Medicine, University of Sichuan, Chengdu 610041, Sichuan, People s Republic of China
Chin J Physiol 56:83-9. 2013b>Cyclin G1 is the only cyclin that has either positive or negative effects on cell growth. Our previous study found decreased expression of cyclin G1 in human endometrial carcinoma tissues compared with normal endometrial tissues...
- Genome-Wide Analyses Reveal Gene Influence on HIV Disease Progression and HIV-1C Acquisition in Southern AfricaWen Xie
Boston, United States
AIDS Res Hum Retroviruses . 2017..Two SNPs near HCG22 (chr 6, peak variant rs2535307, combined P = 3.72×10-7, minor allele as risky allele)and CCNG1 (chr 5, peak variant kgp22385164, combined P =1...
- Evaluation of toxicogenomics approaches for assessing the risk of nongenotoxic carcinogenicity in rat liverJohannes Eichner
Center for Bioinformatics Tuebingen ZBIT, University of Tuebingen, Tubingen, Germany
PLoS ONE 9:e97678. 2014..Among the genes most frequently incorporated into prediction models were Phlda3, Cdkn1a, Akr7a3, Ccng1 and Abcb4.
- Progesterone-induced cyclin G1 inhibits the proliferation of endometrial epithelial cell and its possible molecular mechanismD z Yuan
Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, P R China
Horm Metab Res 46:761-7. 2014..Our previous studies have shown that cyclin G1 was progesterone-dependent in mouse endometrial epithelium at peri-implantation, and exogenous cyclin G1 ..
- MicroRNA sponge blocks the tumor-suppressing functions of microRNA-122 in human hepatoma and osteosarcoma cellsJi Ma
Central Laboratory, Shanghai Tenth People s Hospital of Tongji University, Shanghai 200072, P R China
Oncol Rep 32:2744-52. 2014..that miR-122-SP effectively sequestered ectopic miR-122 and restored the expression of miR-122 which targets cyclin G1 (CCNG1), Bcl-w and disintegrin and metalloprotease 10...
- Time, dose and ataxia telangiectasia mutated (ATM) status dependency of coding and noncoding RNA expression after ionizing radiation exposureS Kabacik
Public Health England, Centre for Radiation, Chemical and Environmental Hazards, OX11 0RQ, United Kingdom
Radiat Res 183:325-37. 2015..ATF3, MDM2, PUMA and GADD45A) or down-regulation (CCNB1) occurring 2-3 h postirradiation, while DDB2, FDXR and CCNG1 responded with slower kinetics reaching a peak of expression between 5 and 24 h...
- Aluminum oxide nanoparticles alter cell cycle progression through CCND1 and EGR1 gene expression in human mesenchymal stem cellsVaiyapuri Subbarayan Periasamy
Nanobiotechnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, Riyadh, Kingdom of Saudi Arabia
Biotechnol Appl Biochem 63:320-7. 2016..cell cycle progression, and monitoring the expression of cell cycle response genes (PCNA, EGR1, E2F1, CCND1, CCNC, CCNG1, and CYCD3). The Al2 O3 -NPs reduced hMSC viability in a dose- and time-dependent manner...
- Analysis of Gene Expression in the Endocervical Epithelium of Women With Deep EndometriosisAlexander Kopelman
Pelvic Pain and Endometriosis Unit, Gynecology Department, Paulista School of Medicine, Federal University of Sao Paulo EPM UNIFESP, Sao Paulo, Brazil
Reprod Sci 23:1269-74. 2016..Nine genes were identified as being upregulated: 5 cell cycle genes (cyclin B1 [CCNB1], cyclin G1 [CCNG1], cullin 1 [CUL1], general transcription factor IIH, polypeptide 1 [GTF2H1], and proliferating cell ..
- Current concepts in pathophysiology and management of hepatocellular carcinomaAmal H Hamza
Biochemistry Department, Faculty of Science for Girls, King Abdulaziz University, Jeddah, KSA Biochemistry and Nutrition Department, Faculty of Women, Ain Shams University, Cairo, Egypt
Acta Biochim Pol 62:573-80. 2015..of apoptosis enhancing nuclease (Aen), Bcl2-associated X protein (Bax), B-cell translocation gene 2(Btg2), Cyclin G1 (Ccng1) and Cyclin-dependent kinase inhibitor 1A (Cdkn1a) gene expression in HCC+GSE groups as compared to HCC ..
- Carbon nanoparticle induced cytotoxicity in human mesenchymal stem cells through upregulation of TNF3, NFKBIA and BCL2L1 genesVaiyapuri S Periasamy
Nanobiotechnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, Riyadh, Saudi Arabia
Chemosphere 144:275-84. 2016..g., P53, TNF3, CDKN1A, TNFRSF1A, TNFSF10, NFKBIA, BCL2L1) and cell cycle regulation (e.g., PCNA, EGR1, E2F1, CCNG1, CCND1, CCNC, CYCD3) were assessed using qPCR...
- MiR-1271 Inhibits Ovarian Cancer Growth by Targeting Cyclin G1Xiaogang Liu
Department of Gynaecology and Obstetrics, People s Hospital of Yuxi, Yuxi, Yunnan, China mainland
Med Sci Monit 21:3152-8. 2015..Ovarian cancer is the most lethal gynecological malignant cancer in the female genital system. The dysfunction of miRNA contributes to ovarian cancer development...
- MiR-122 partly mediates the ochratoxin A-induced GC-2 cell apoptosisRan Chen
State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, PR China
Toxicol In Vitro 30:264-73. 2015..It showed that Bcl-w was down-regulated after OTA treatment, and caspase-3 was obviously activated. Cyclin G1 (CCNG1) was significantly decreased, and inversely the expression of p53 was increased...
- Molecular mechanisms associated with breast cancer based on integrated gene expression profiling by bioinformatics analysisDi Wu
a Department of Breast Surgery, The First Hospital of Jilin University, Changchun, China and
J Obstet Gynaecol 36:615-21. 2016..Meanwhile, the most significant-related DEGs were found by co-expression network analysis of DEGs. In conclusion, CCNG1 might be involved in the progression of BC via inhibiting cell proliferation, and ADAMTS1 might play a crucial ..
- MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progressionJing Yan
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, 100013, Shenyang, China
J Exp Clin Cancer Res 35:31. 2016It has been proposed that cyclin G1 (CCNG1) participates in p53-dependent G1-S and G2 checkpoints and might function as an oncogenic protein in the initiation and metastasis of ovarian carcinoma...
- Can tobacco use promote HCV-induced miR-122 hijacking and hepatocarcinogenesis?Lijun Zhao
College of Life Sciences, Shaanxi Normal University, 199 South Chang an Road, Xi an 710062, China
Med Hypotheses 80:131-3. 2013..as a competing endogenous RNA (ceRNA), HCV replication can liberate miR-122's direct target, oncogenic gene cyclin G1 (CCNG1); furthermore, simultaneous tobacco use can synergistically enhance this competing effect via HCV ..
- High and low dose responses of transcriptional biomarkers in ex vivo X-irradiated human bloodGrainne Manning
Biological Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Health Protection Agency, Chilton, Didcot, Oxfordshire, UK
Int J Radiat Biol 89:512-22. 2013..However, little is known about the dose-responses of transcriptionally responsive genes, especially at low doses. In this study, we investigated these dose-responses and assessed inter-individual variability...
- Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progressionDaisuke Hibi
Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
J Toxicol Sci 38:57-69. 2013..and Ccnb1), G(2)/M arrest in response to DNA damage (Chek1 and Wee1), and p53-associated factors (Phlda3 and Ccng1). Significant increases in the mRNA levels of many of these genes were observed in the OM using real-time RT-PCR...
- Leukemogenesis as a new approach to investigate the correlation between up regulated gene 4/upregulator of cell proliferation (URG4/URGCP) and signal transduction genes in leukemiaYavuz Dodurga
Department of Medical Biology, School of Medicine, Pamukkale University, Kınıklı Kampüsü Morfoloji Binasi Kat 3, Kinikli Denizli, Turkey
Mol Biol Rep 40:3043-8. 2013..CHEK1, URG4/URGCP, CCNG1, CCNC, CDC16, KRAS, CDKN2D genes in the T-ALL group; CCND2, ATM, CDK8, CHEK1, TP53, CHEK2, CCNG2, CDK4, CDKN2A, ..
- Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progressionWen Wen
International Cooperation Laboratory on Signal Transduction of Eastern Hepatobiliary Surgery Institute, Shanghai, China
Hepatology 55:1787-98. 2012b>Cyclin G1 deficiency is associated with reduced incidence of carcinogen-induced hepatocellular carcinoma (HCC), but its function in HCC progression remains obscure. We report a critical role of cyclin G1 in HCC metastasis...
- The role of progesterone and its receptor on cyclin G1 expression in endometrial carcinoma cellsFang Liu
Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China
Reprod Sci 19:1205-10. 2012b>Cyclin G1 protein is expressed in normal endometrial epithelial cells in a progesterone-dependent manner. It is an important mediator of the inhibiting effect of progesterone on cell proliferation...
- Cloning, localization and functional properties of a cGMP-gated channel in photoreceptor cells from fish pineal glandSonia Decressac
Laboratoire des Biomembranes et Signalisation Cellulaire, Unité Mixte de Recherche CNRS 6558, Universite de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
J Pineal Res 33:225-33. 2002..cells and the expressed channel in a human cell line (HEK 293 cells) have properties similar to those of cone-CNG (cCNG)-3 channels...
- The relationship between Cyclin G1 and survival in patients treated surgically for HCCXiaopeng Cui
Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China
Hepatogastroenterology 60:153-9. 2013b>Cyclin G1 is a cell-cycle-regulatory protein that is frequently seen in elevated amounts in malignant tissue, including astrocytomas; melanoma; carcinoma of the esophagus, lung, and breast; as well as cancer of the cervix, uterus, and ..
- Germline variation in TP53 regulatory network genes associates with breast cancer survival and treatment outcomeMaral Jamshidi
Department of Obstetrics and Gynecology, Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, 00029 Helsinki, Finland
Int J Cancer 132:2044-55. 2013Germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ was previously suggested to have an impact on drug response in vitro...
- Differential gene expression profiling between genotoxic and non-genotoxic hepatocarcinogens in young rat liver determined by quantitative real-time PCR and principal component analysisKazuya Suenaga
Functional Genomics Laboratory, School of Science and Engineering, Aoyama Gakuin University, Fuchinobe 5 10 1, Chuo Ku, Sagamihara, Kanagawa 252 5258, Japan
Mutat Res 751:73-83. 2013..from the non-genotoxic hepatocarcinogen and the non-genotoxic non-hepatocarcinogen at 4h based on 16 genes (Ccnf, Ccng1, Cyp4a10, Ddit4l, Egfr, Gadd45g, Gdf15, Hspb1, Igfbp1, Jun, Myc, Net1, Phlda3, Pml, Rcan1 and Tubb2c) and at 48 h ..
- MicroRNA-9 inhibition of cell proliferation and identification of novel miR-9 targets by transcriptome profiling in breast cancer cellsS Duygu Selcuklu
Genetics and Biotechnology Laboratory, Centre for Chromosome Biology, National University of Ireland, Galway, Ireland
J Biol Chem 287:29516-28. 2012..of the transcriptome of MCF-7 cells overexpressing miR-9 identified six novel direct miR-9 targets (AP3B1, CCNG1, LARP1, MTHFD1L, MTHFD2, and SRPK1)...
- Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cellsNikta Pashai
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 7:e39088. 2012..These genes were exclusively up-regulated in ESCs, IPSCs and ECCs including PARP1, CCNE1, CDK6, AURKA, MAD2L1, CCNG1, and CCNB1 which are involved in cell cycle regulation, cellular metabolism and DNA repair and replication...
- Discrimination of genotoxic and non-genotoxic hepatocarcinogens by statistical analysis based on gene expression profiling in the mouse liver as determined by quantitative real-time PCRTakashi Watanabe
Aoyama Gakuin University, Sagamihara, Kanagawa, Japan
Mutat Res 747:164-75. 2012..analysis using principal component analysis (PCA) of the gene expression profiles for 7 genes (Btg2, Ccnf, Ccng1, Lpr1, Mbd1, Phlda3 and Tubb2c) at 4h and for 12 genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15, Lrp1, Mbd1, ..
- The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesisDaechun Kang
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
Genes Chromosomes Cancer 52:126-39. 2013..analysis using Affymetrix GeneChip(®) showed that WHSC1L1 affected the expression of a number of genes including CCNG1 and NEK7, which are known to play crucial roles in the cell cycle progression at mitosis...
- Cell population genetics and deep sequencing: a novel approach for drivers discovery in hepatocellular carcinomaClara Alsinet
University of Barcelona, Catalonia, Spain
J Hepatol 56:1198-200. 2012..Hence, by using a cell-population genetic definition,this approach identified three coding changes (CCNG1, P62,and an indel/fusion gene) as tumor driver mutations...
- Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activitySaifeng Wang
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences CAS, Beijing, PR China
Hepatology 55:730-41. 2012..We next identified cyclin G(1) as an miR-122 target from multiple candidate target genes that are involved in the regulation of HBV ..
- The expression of cyclin G in nasopharyngeal carcinoma and its significanceXing Xing Ye
Department of Otolaryngology, Taizhou Municipal Hospital, Taizhou, Zhejiang, China
Clin Exp Med 12:21-4. 2012To investigate the expression of cyclin G1, cyclin G2 in nasopharyngeal carcinoma (NPC) cell lines and its significance...
- Epstein-Barr virus downregulates microRNA 203 through the oncoprotein latent membrane protein 1: a contribution to increased tumor incidence in epithelial cellsHaibo Yu
Cancer Research Institute, Central South University, Changsha, Hunan, People s Republic of China
J Virol 86:3088-99. 2012..EBV-LMP1 mediated the downregulation of miR-203 at the primary transcript level. E2F3 and CCNG1 were identified as target genes of miR-203...
- Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrestP Russell
University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
Oncogene 31:2450-60. 2012..However, the mechanisms that determine these outcomes remain unclear. Here, we identify a novel role for cyclin G1 (CCNG1), an atypical cyclin...
- Comparative transcript profiles of cell cycle-related genes in mouse primordial germ cells, embryonic stem cells and embryonic germ cellsEleonora Sorrentino
Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy
Gene Expr Patterns 7:714-21. 2007..Except for higher mRNA levels of Ccng (CyclinG1) in EG and ES cells in comparison to PGCs, no difference among 20 genes of the S and 12 genes of G2/M ..
- Cyclin B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodesJia Qing Li
Department of Pathology and Host Defense, Kagawa Medical University, Kagawa 761 0793, Japan
Int J Oncol 22:1101-10. 2003..B1 expression remains unclear during colorectal carcinogenesis and during later metastasis to lymph nodes, and cyclin G1 expression is not clear in colorectal tumors...
- Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinomaLaura Gramantieri
Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
Cancer Res 67:6092-9. 2007..Here, we show that miR-122a can modulate cyclin G1 expression in HCC-derived cell lines and an inverse correlation between miR-122a and cyclin G1 expression exists ..
- Structure and chromosomal assignment of the human cyclin G geneY Endo
Department of Biochemistry, Fukushima Medical College, Japan
Genomics 38:92-5. 1996Human cDNA and genomic DNA encoding cyclin G were cloned and analyzed. The amino acid sequence of cyclin G is well conserved among mammals...
- The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondriaM V Kato
Molecular Oncology Laboratory, Tsukuba Life Science Center, The Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
Leuk Lymphoma 33:181-6. 1999..In this process, p53 recovered the wild-type p53 function and the expression of the p21 (waf1/cip1/sdi1), cyclin G1 and gadd45 genes was increased...
- Truncation of WT1 results in downregulation of cyclin G1 and IGFBP-4 expressionK J Wagner
Sir Alastair Currie CRC Laboratories, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
Biochem Biophys Res Commun 287:977-82. 2001..Examination of gene expression in these cells using cDNA macroarrays suggests two novel WT1 transcriptional targets, cyclin G1 (Ccng1), and insulin-like growth factor binding protein 4 (Igfbp4).
- Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrestDavid A Bennin
Department of Pharmacology, University of Wisconsin, Madison, WI 53706 1532, USA
J Biol Chem 277:27449-67. 2002Cyclin G2, together with cyclin G1 and cyclin I, defines a novel cyclin family expressed in terminally differentiated tissues including brain and muscle...
- Increased Cyclin G1 Immunoreactivity During Alzheimer's DiseaseKelly L Jordan-Sciutto
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Alzheimers Dis 1:409-417. 1999..A recently described member of the cyclin gene family, cyclin G1, is expressed in post-mitotic neurons in the adult rat brain and is expressed at high levels after brain injury...
- Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathwaysLili Zhao
Department of Pharmacology, College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Mol Cancer Res 1:195-206. 2003b>Cyclin G1 is a p53-responsive gene that is induced in alternative reading frame (ARF)-arrested cells, yet its role in growth control is unclear. We tested its effects on growth and involvement in the ARF-Mdm2-p53 tumor suppressor pathway...
- Modulation of p53 and p73 levels by cyclin G: implication of a negative feedback regulationTakao Ohtsuka
Hematology and Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Oncogene 22:1678-87. 2003b>Cyclin G is a transcriptional target gene of tumor suppressor p53. Recent studies present evidence that cyclin G may play a central role in the p53-Mdm2 autoregulated module, but the precise function of cyclin G remains elusive...
- Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expressionM C Horne
Bristol Meyers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121, USA
J Biol Chem 271:6050-61. 1996We describe the isolation and characterization of cDNAs encoding full-length human and murine cyclin G1 and a novel human homologue of this cyclin designated cyclin G2...
- Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 ratsLena Wester
Institute für Immunologie, Universitat Rostock, Rostock, Germany
Arthritis Res Ther 5:R361-72. 2003..Cd28), the mast cell specific protease 1 (Mcpt1), the carboxylesterase precursor (Ces2), K-cadherin (Cdh6), cyclin G1 (Ccng1), DNA polymerase IV (Primase) and the tumour associated glycoprotein E4 (Tage) were expressed at a lower ..
- Development of a comprehensive comparative radiation hybrid map of bovine chromosome 7 (BTA7) versus human chromosomes 1 (HSA1), 5 (HSA5) and 19 (HSA19)M Gautier
Laboratoire de Génétique Biochimique et de Cytogénétique, Département de Génétique Animale, INRA CRJ, Jouy en Josa, France
Cytogenet Genome Res 102:25-31. 2003..HSA1 (TRIM17), HSA5 (MAN2A1, LMNB1, SIAT8D and FLJ1159) and HSA19 (VAV1), and the three others (AP3B1, APC and CCNG1) on BTA10...
- The negative role of cyclin G in ATM-dependent p53 activationTakao Ohtsuka
Cancer Biology Program, Hematology Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Oncogene 23:5405-8. 2004b>Cyclin G is one of the earliest p53 target genes to be identified, but its function in the p53 pathway has been elusive...
- Dose and dose-rate effects of low-dose ionizing radiation on activation of Trp53 in immortalized murine cellsTakashi Sugihara
Department of Radiobiology, Institute for Environmental Sciences, 1 7 Ienomae, Obuchi, Rokkasho, Kamikita, Aomori 039 3212, Japan
Radiat Res 162:296-307. 2004..Microarray analysis revealed up-regulation of six Trp53-mediated genes (Cdkn1a/ p21, Mdm2, Sip27, Ccng1/cyclin G1, Ei24/Pig8 and Dinb/ Polk) after exposure of cells to low-dose-rate radiation for 72 h...
- Exposure of hematopoietic stem cells to benzene or 1,4-benzoquinone induces gender-specific gene expressionBrenda Faiola
CIIT Centers for Health Research, Research Triangle Park, NC, USA
Stem Cells 22:750-8. 2004..Males exposed to benzene exhibited higher mRNA levels for xpc, ku80, ccng, and wig1. These gene expression differences may partially explain the gender disparity in benzene susceptibility...
- Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinomaDemetrius M Kokkinakis
Department of Pathology, University of Pittsburgh, PA 15213 1863, USA
Mol Cancer Ther 4:1338-48. 2005..PIN1, FEN1, and cABL up-regulation and LMNB1, AREG, RhoB, CCNG, TYMS, F3, and MGMT down-regulation suggest that methionine stress sensitizes the tumor cells to DNA-alkylating ..
- A common cis-element in promoters of protein synthesis and cell cycle genesLucjan S Wyrwicz
BioInfoBank Institute, Poznan, Poland
Acta Biochim Pol 54:89-98. 2007..The motif was identified in a substantial fraction of promoters of cell cycle genes, like cyclins (CCNC, CCNG1), as well as transcription regulators (TAF7, TAF13, KLF7, NCOA2), chromatin structure modulators (HDAC2, TAF6L), ..
- Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2AHongyun Li
Department of Biological Sciences, Columbia University, New York, New York 10027, USA
Mol Cell Biol 29:919-28. 2009Although the cyclin G1 gene is known to be regulated at the transcriptional level by p53, less is understood about the turnover of its protein product...
- Cyclin degradation for cancer therapy and chemopreventionSarah J Freemantle
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
J Cell Biochem 102:869-77. 2007..Evidence for cyclin D1 as a molecular pharmacologic target and biological marker for clinical response is based on experience of proof of principle trials...
- Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the ratPeter J M Hendriksen
TNO Quality of Life, Zeist, The Netherlands
Toxicol Appl Pharmacol 225:171-88. 2007..Many of the genes induced by mixtures but not by single compounds, such as Id2, Nr2f6, Tnfrsf1a, Ccng1, Mdm2 and Nfkb1 in the liver, are known to affect cellular proliferation, apoptosis and tissue-specific function...
- Upregulation of stress-response genes with cell cycle arrest induced by carbon ion irradiation in multiple murine tumors modelsKaori Imadome
RadGenomics Project, National Institute of Radiological Sciences, Inage, Chiba, Japan
Cancer Biol Ther 7:208-17. 2008..To elucidate the in vivo biological effects induced by carbon-ion irradiation using comprehensive expression analysis...
- Inverse dose-rate-effects on the expressions of extra-cellular matrix-related genes in low-dose-rate gamma-ray irradiated murine cellsTakashi Sugihara
Department of Radiobiology, Institute for Environmental Sciences, Kamikita, Aomori, Japan
J Radiat Res 49:231-40. 2008..into two types, in which one was up-regulated in LDR-, ini-HDR-, and end-HDR irradiation such as Cdkn1a and Ccng1, which were reported as p53-dependent genes, and the other was up-regulated in LDR- and ini-HDR irradiations such ..
- Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1Haeng Ran Seo
Division of Radiation Effect, Korea Institute of Radiological and Medical Sciences, Seoul 139 706, Korea
J Biol Chem 283:15601-10. 2008It has been reported previously that cyclin G1 enables cells to overcome radiation-induced G(2) arrest and increased cell death and that these effects are mediated by transcriptional activation of cyclin B1...
- Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesisChi Hwa Wu
Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, California, United States of America
PLoS Genet 4:e1000090. 2008..of genes involved in a diverse array of cellular functions including: BZW2, H2AFY, SFRS3, NAP1L1, NOLA2, UBE2D2, CCNG1, LIFR, FABP3, and EDG1...
- A role for the cyclin box in the ubiquitin-mediated degradation of cyclin G1Denise M Piscopo
Molecular Oncology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
Cancer Res 68:5581-90. 2008b>Cyclin G1 was identified as a transcriptional target of p53 that encodes a protein with strong homology to the cyclin family of cell cycle regulators...
- Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53Maria L Simões
Section of Molecular Carcinogenesis, Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey, UK
Toxicol Appl Pharmacol 232:86-98. 2008..Some genes, including INSIG1, EGR1, CAV1, LCN2 and CCNG1, were differentially expressed in the two cell lines...
- Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cellsMónica López-Guerra
Unitat d Hematopatologia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
Haematologica 93:1843-51. 2008....
- Cadmium-induced differential toxicogenomic response in resistant and sensitive mouse strains undergoing neurulationJoshua F Robinson
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
Toxicol Sci 107:206-19. 2009..cell cycle-related classifications, however, only in the C57 we observed upregulation of p53-dependent mediators Ccng1 and Pmaip1, previously associated with cell cycle arrest, apoptosis and NTD formation...
- Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome dataYong Tao
Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, People s Republic of China
Proc Natl Acad Sci U S A 108:12042-7. 2011..Hence, by using a cell-population genetic definition, this approach identified three coding changes (CCNG1, P62, and an indel/fusion gene) as tumor driver mutations...
- MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cellsJose L R Brito
Institute for Cancer Research, Section of Haemato oncology, London, UK
Haematologica 94:78-86. 2009..The involvement of MMSET in the pathogenesis of t(4;14) multiple myeloma and the mechanism or genes deregulated by MMSET upregulation are still unclear...
- Dose-dependent alterations in gene expression in mouse liver induced by diethylnitrosamine and ethylnitrosourea and determined by quantitative real-time PCRTakashi Watanabe
Functional Genomics Laboratory, School of Science and Engineering, Aoyama Gakuin University, Fuchinobe 5 10 1, Sagamihara, Kanagawa 229 0006, Japan
Mutat Res 673:9-20. 2009..Twenty-one genes exhibited a distinct dose-dependent increase in expression at 4h for both carcinogens [Bax, Btg2, Ccng1, Cdkn1a, Cyp4a10, Cyp21a1, Fos, Gadd45b, Gdf15, Hmox1, Hspb1, Isg20l1, Jun, Mbd1, Mdm2, Myc, Net1, Plk2, Ppp1r3c, ..
- Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesisMorgan Newman
School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, Australia
J Alzheimers Dis 16:133-47. 2009..Five of these have known function and showed increased expression: cyclin G1 (ccng1), prosaposin (psap), cathepsin Lb (ctslb), heat shock protein 70kDa (hsp70) and hatching enzyme 1 (he1)...
- Upregulation of stem cell genes in multidrug resistant K562 leukemia cellsGustav Lehne
Department of Clinical Pharmacology, Oslo University Hospital Rikshospitalet, Norway
Leuk Res 33:1379-85. 2009..g. KIT and HOXB4), anti-apoptotic genes (e.g. IGF1R and CCNG1), and downregulation of pro-apoptotic genes (e.g. CASP4, 6 and 7)...
- Microarray analysis identifies differentially expressed genes induced by human papillomavirus type 18 E6 silencing RNAWei Min
Institute of Molecular Biology, Southern Medical University, Guangzhou, People s Republic of China
Int J Gynecol Cancer 19:547-63. 2009..We analyzed the gene functions and cellular pathways in detail, including cell cycle-related genes, CCNG1 and p21; apoptosis-related genes, CASP4, CASP6, IGFBP3, and DFFA; ubiquitin proteolysis pathway-related genes, ..
- MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cellsFrancesca Fornari
Dipartimento di Medicina Clinica e CRBA, Policlinico S Orsola Malpighi, Bologna, Italy
Cancer Res 69:5761-7. 2009..We have previously shown that miR-122 can regulate the expression of cyclin G1, whose high levels have been reported in several human cancers...
- [Expression of P27(kip1) and cyclin G in patients with acute leukemia and its correlation]Hui Yu Chen
Department of Laboratory Examination, Fujian Provincial Maternal and Children Hospital, Fuzhou 350001, Fujian Province, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 17:847-51. 2009This study was purposed to explore the expression of P27(kip1)and cyclin G in patients with acute leukemia (AL) and its correlation...
- Gene expression following ionising radiation: identification of biomarkers for dose estimation and prediction of individual responseSylwia Kabacik
Biological Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Health Protection Agency, Chilton, Didcot, Oxfordshire, UK
Int J Radiat Biol 87:115-29. 2011..To establish a panel of highly radiation responsive genes suitable for biological dosimetry and to explore inter-individual variation in response to ionising radiation exposure...
- Gene expression analysis in radiotherapy patients and C57BL/6 mice as a measure of exposure to ionizing radiationAshley N Filiano
Department of Pharmacology and Toxicology, University of Alabama at Birmingham, AL 35294, USA
Radiat Res 176:49-61. 2011..Of eight biodosimetry genes identified in cancer patients ( ACTA2 , BBC3 , CCNG1 , CDKN1A , GADD45A , MDK , SERPINE1 , Tnfrsf10b ), expression of BBC3 , CCNG1 , CDKN1A , SERPINE1 and Tnfrsf10b ..