CCL4

Summary

Gene Symbol: CCL4
Description: C-C motif chemokine ligand 4
Alias: ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4, C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein, MIP-1-beta(1-69), PAT 744, SIS-gamma, T-cell activation protein 2, chemokine (C-C motif) ligand 4, lymphocyte activation gene 1 protein, macrophage inflammatory protein 1-beta, secreted protein G-26, small inducible cytokine A4 (homologous to mouse Mip-1b)
Species: human

Top Publications

  1. ncbi CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection
    W Shao
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Genes Immun 8:224-31. 2007
  2. pmc Colchicine antimitosis abolishes resiliency of postnatally developing rats to chlordecone-amplified carbon tetrachloride hepatotoxicity and lethality
    A Dalu
    Division of Toxicology and Louisiana Institute of Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University, Monroe, LA 71209 0470, USA
    Environ Health Perspect 106:597-606. 1998
  3. ncbi CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection
    M B Zaitseva
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 161:3103-13. 1998
  4. ncbi Zonal location of compensatory hepatocyte proliferation following chemically induced hepatotoxicity in rats and humans
    V M Lee
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Toxicol Pathol 26:621-7. 1998
  5. pmc Beta-chemokines are induced by Mycobacterium tuberculosis and inhibit its growth
    Jussi J Saukkonen
    Pulmonary Care Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Infect Immun 70:1684-93. 2002
  6. doi HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages
    Takashi Chihara
    Center for AIDS Research, Kumamoto University, Kumamoto 860 0811, Japan
    J Immunol 188:3620-7. 2012
  7. pmc Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines
    A Trkola
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10021, USA
    J Virol 72:396-404. 1998
  8. doi HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection
    Emanuele Fanales-Belasio
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 182:2888-97. 2009
  9. ncbi Cerebrospinal fluid beta chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1
    S L Letendre
    University of California, HIV Neurobehavioral Research Center, San Diego, California 92103, USA
    J Infect Dis 180:310-9. 1999
  10. ncbi The presence of chemokine (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-positive cells and chemokine receptor (CCR5, CXCR3)-positive cells in inflamed human gingival tissues
    Hiroaki Kabashima
    Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    Cytokine 20:70-7. 2002

Research Grants

  1. Sanjoy Roychowdhury; Fiscal Year: 2014
  2. Heather L Francis; Fiscal Year: 2015
  3. Samuel M Goldman; Fiscal Year: 2014
  4. PROTECTION FROM ENVIRONMENTAL TOXINS/MUTAGENS BY INDOLES
    HOWARD SHERTZER; Fiscal Year: 1990
  5. MECHANISMS OF HEPATOTOXICITY BY ENVIRONMENTAL POLLUTANTS
    Ronald Thurman; Fiscal Year: 1991
  6. TOXINS AND HEPATOCELLULAR PHOSPHOGLYCERIDE CATABOLISM
    ROBERT LAMB; Fiscal Year: 1990
  7. TOXIC LIVER INJURY: CA2+, PLA2, PROTEASES & EICONSANOIDS
    ERIC GLENDE; Fiscal Year: 1993
  8. THE INTERPLAY BETWEEN HEPATIC GROWTH AND METABOLISM
    Kim Olthoff; Fiscal Year: 2004
  9. INDUCTION OF P21 AND P27 IN LIVER AFTER CCL4 INJURY
    ANGELA TYNER; Fiscal Year: 2005
  10. REPLACEMENT OF SULFITE OXIDASE AFTER CC14 DAMAGE
    MICHAEL BRABEC; Fiscal Year: 1980

Detail Information

Publications252 found, 100 shown here

  1. ncbi CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection
    W Shao
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Genes Immun 8:224-31. 2007
    ..they both consist of non-allelic isoforms encoded by different genes, namely chemokine (C-C motif) ligand 3 (CCL3), CCL4, CCL3-like 1 (CCL3L1) and CCL4L1. The products of these genes and of CCL5 (encoding RANTES, i.e...
  2. pmc Colchicine antimitosis abolishes resiliency of postnatally developing rats to chlordecone-amplified carbon tetrachloride hepatotoxicity and lethality
    A Dalu
    Division of Toxicology and Louisiana Institute of Toxicology, College of Pharmacy and Health Sciences, Northeast Louisiana University, Monroe, LA 71209 0470, USA
    Environ Health Perspect 106:597-606. 1998
    ..that rats are resilient to the hepatotoxic and lethal combination of chlordecone (CD) and carbon tetrachloride (CCl4) during early postnatal development...
  3. ncbi CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection
    M B Zaitseva
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 161:3103-13. 1998
    ..Our data provide strong evidence that CXCR4 and CCR5 function as coreceptors for HIV-1 infection of human thymocytes...
  4. ncbi Zonal location of compensatory hepatocyte proliferation following chemically induced hepatotoxicity in rats and humans
    V M Lee
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Toxicol Pathol 26:621-7. 1998
    ..The perivenous necrogens N-nitrosodiethylamine, carbon tetrachloride (CCl4), bromobenzene, and acetaminophen all induced periportal hepatocyte proliferation...
  5. pmc Beta-chemokines are induced by Mycobacterium tuberculosis and inhibit its growth
    Jussi J Saukkonen
    Pulmonary Care Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Infect Immun 70:1684-93. 2002
    ..tuberculosis two- to threefold, a novel finding. Thus, beta-CK contribute to the innate immune response to M. tuberculosis infection, and their diminution may promote the intracellular survival of M. tuberculosis...
  6. doi HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages
    Takashi Chihara
    Center for AIDS Research, Kumamoto University, Kumamoto 860 0811, Japan
    J Immunol 188:3620-7. 2012
    ....
  7. pmc Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines
    A Trkola
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10021, USA
    J Virol 72:396-404. 1998
    ..Thus, for CCR5, the rank order for down-regulation was also RANTES, MIP-1beta, MIP-1alpha...
  8. doi HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection
    Emanuele Fanales-Belasio
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 182:2888-97. 2009
    ....
  9. ncbi Cerebrospinal fluid beta chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1
    S L Letendre
    University of California, HIV Neurobehavioral Research Center, San Diego, California 92103, USA
    J Infect Dis 180:310-9. 1999
    ..Low, but detectable, levels of CSF MIP-1alpha were strongly associated with dementia, suggesting that higher levels may have neuroprotective effects...
  10. ncbi The presence of chemokine (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-positive cells and chemokine receptor (CCR5, CXCR3)-positive cells in inflamed human gingival tissues
    Hiroaki Kabashima
    Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    Cytokine 20:70-7. 2002
    ..In contrast, no factor expression was observed in periodontally healthy gingival tissue. Our findings suggest that these chemokines may be responsible for modulating the process of infectious disease such as marginal periodontitis...
  11. doi Cysteinyl leukotrienes induce macrophage inflammatory protein-1 in human monocytes/macrophages
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Int Arch Allergy Immunol 148:147-53. 2009
    ..Macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta are known for their chemotactic and proinflammatory effects on monocytes/macrophages which have a cysteinyl leukotriene 1 (CysLT(1)) receptor...
  12. pmc Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme
    Min Ren
    Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    EMBO J 29:3952-66. 2010
    Macrophage inflammatory protein-1 (MIP-1), MIP-1α (CCL3) and MIP-1β (CCL4) are chemokines crucial for immune responses towards infection and inflammation. Both MIP-1α and MIP-1β form high-molecular-weight aggregates...
  13. pmc CCAAT/enhancer-binding protein β and NF-κB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1β
    Zhiqi Zhang
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 285:33092-103. 2010
    ..transcriptional regulation, deletion constructs of selected chemokine gene promoters, the human CCL3 (MIP-1α) and CCL4 (MIP-1β), were transfected into human chondrocytes with or without IL-1β...
  14. ncbi Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity
    Ennan Guan
    Division of Therapeutic Proteins, CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 277:32348-52. 2002
    ..substantial amounts of the beta-chemokines macrophage inflammatory protein (MIP)-1 alpha/CCL3 and MIP-1 beta/CCL4, both of which inhibit infection of cells with human immunodeficiency virus type 1 (HIV-1)...
  15. doi Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195
    Caryn Gonsalves
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Immunol 185:6253-64. 2010
    ..In this study, we observed that ET-1 increased the expression of the chemokines MIP-1β or CCL4. ET-1-induced MIP-1β mRNA expression in THP-1 cells and human peripheral blood monocytes occurred via the ..
  16. ncbi HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: involvement of Nef endocytotic signals and NF-kappa B activation
    Eleonora Olivetta
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Immunol 170:1716-27. 2003
    ..Our data add new hints supporting the idea that the presence of Nef is per se heavily detrimental for monocyte/macrophages and relative cross-talking cell types...
  17. ncbi In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
    G Scarlatti
    Unit of Immunobiology of HIV, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Nat Med 3:1259-65. 1997
    ..These results suggest an adaptive evolution of HIV-1 in vivo, leading to escape from the control of the antiviral C-C chemokines...
  18. ncbi Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
    M Farzan
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:667-76. 1999
    ..CXCR4, another important HIV-1 coreceptor, is also sulfated. Tyrosine sulfation may contribute to the natural function of many 7TMS receptors and may be a modification common to primate immunodeficiency virus coreceptors...
  19. pmc Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alpha
    Y Maeda
    Department of Biodefence and Medical Virology, School of Medicine, Kumamoto University, Kumamoto, Japan
    J Virol 74:1787-93. 2000
    ..These results indicated that V2 combined with the V3 region of the CCR5-tropic HIV-1 envelope modulates the sensitivity of HIV-1 to C-C chemokines without altering the ability to use chemokine receptors...
  20. ncbi Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5
    Dzung H Nguyen
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Blood 99:4298-306. 2002
    ..by hydroxypropyl-beta-cyclodextrin (BCD) significantly reduced the binding and signaling of macrophage inflammatory protein 1 beta (MIP-1 beta) using CCR5-expressing CEM-NKR T cells...
  21. ncbi Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES
    Nieves Fernández
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, and Unidad de Investigacion, Hospital Clinico Universitario, Valladolid, Spain
    J Immunol 169:3321-8. 2002
    ....
  22. pmc Genetic variation in the CCL18-CCL3-CCL4 chemokine gene cluster influences HIV Type 1 transmission and AIDS disease progression
    William S Modi
    SAIC Frederick, Inc, Basic Research Program, Frederick, MD 21702 1201, USA
    Am J Hum Genet 79:120-8. 2006
    CCL3 (MIP-1 alpha), CCL4 (MIP-1 beta), and CCL18 (DC-CK1/PARC/AMAC-1) are potent chemoattractants produced by macrophages, natural killer cells, fibroblasts, mast cells, CD4(+) T cells, and CD8(+) T cells...
  23. pmc Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages
    Laura Fantuzzi
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Blood 111:3355-63. 2008
    ..PC-PLC activation through CCR5 is specifically induced by gp120, since triggering CCR5 through its natural ligand CCL4 (MIP-1beta) does not affect PC-PLC cellular distribution and enzymatic activity, as well as CCL2 secretion, thus ..
  24. doi Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production
    Masahiro Abe
    Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Bone Miner Metab 27:16-23. 2009
    ....
  25. doi Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta through the NF-kappaB and MAPK pathways in rheumatoid arthritis
    Wenxin Zheng
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Arthritis Rheum 60:1957-65. 2009
    ..In this study, we investigated the role and molecular mechanism of OPN in the induction of 2 key chemokines, monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory protein 1beta (MIP-1beta), in RA...
  26. pmc Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage
    Kevin O Saunders
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Cell Immunol 266:154-64. 2011
    ..We define a multifactorial cytokine profile of CD8(+) T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication...
  27. ncbi Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES
    C Combadiere
    The Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 60:147-52. 1996
    ..These data suggest that CC CKR5 is a G(i)-coupled receptor that may mediate monocyte responses to MIP-1alpha, MIP-1beta, and RANTES...
  28. pmc Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
    ....
  29. ncbi HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
    S Swingler
    University of Massachusetts Medical Center, Program in Molecular Medicine, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Med 5:997-103. 1999
    ..These results indicate a role for Nef in lymphocyte recruitment and activation at sites of virus replication...
  30. ncbi Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses
    Emanuele Fanales-Belasio
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Immunol 168:197-206. 2002
    ..Thus, Tat can act as both Ag and adjuvant, capable of driving T cell-mediated immune responses...
  31. pmc A novel motif in HIV-1 Nef that regulates MIP-1beta chemokine release in macrophages
    Lue Dai
    University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    J Virol 84:8327-31. 2010
    ..This further underscores Nef as a modular protein with genetically separable activities that may contribute to its role in viral replication and pathogenicity...
  32. ncbi CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5
    A Trkola
    The Aaron Diamond AIDS Research Centre, The Rockefeller University, New York 10016, USA
    Nature 384:184-7. 1996
    ..Interference with HIV-1 binding to one or both of its receptors (CD4 and CCR-5) may be an important mechanism of virus neutralization...
  33. ncbi HIV-1 Vpr regulates expression of beta chemokines in human primary lymphocytes and macrophages
    K Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
    J Leukoc Biol 68:366-72. 2000
    ..These results suggest that a Vpr-mediated increase in virus replication could be in part through down-regulation of chemokine production...
  34. ncbi HIV-1 viral protein R (Vpr) & host cellular responses
    Richard Yuqi Zhao
    Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 600, Baltimore, MD 21201, USA
    Indian J Med Res 121:270-86. 2005
    ..Strategies with potential application for future antiviral therapies directed at suppressing Vpr activities are described...
  35. ncbi High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR
    P J Lodi
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892
    Science 263:1762-7. 1994
    ..Calculation of the solvation free energies of dimerization suggests that the formation and stabilization of the two different types of dimers arise from the burial of hydrophobic residues...
  36. ncbi Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
    F Cocchi
    Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA
    Science 270:1811-5. 1995
    ..These data may have relevance for the prevention and therapy of AIDS...
  37. ncbi The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    F Cocchi
    Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
    Nat Med 2:1244-7. 1996
    ..The ability of the chemokines to block the early steps of HIV infection could be exploited to develop novel therapeutic approaches for AIDS...
  38. ncbi HIV-1 gp120 stimulates the production of beta-chemokines in human peripheral blood monocytes through a CD4-independent mechanism
    L Fantuzzi
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 166:5381-7. 2001
    ..The expression of these related polypeptides may represent an important cellular response for regulating both the extent of viral infection and the recruitment of immune cells...
  39. pmc Induction of rapid and extensive beta-chemokine synthesis in macrophages by human immunodeficiency virus type 1 and gp120, independently of their coreceptor phenotype
    W Choe
    Division of Molecular Virology, St Luke s Roosevelt Hospital Center, Columbia University, New York, New York 10019, USA
    J Virol 75:10738-45. 2001
    ..We conclude that human macrophages respond rapidly to R5 and X4 envelope binding by production of high levels of physiologically active proteins that are implicated in HIV-1 pathogenesis...
  40. ncbi Differential chemokine expression profiles in human peripheral blood T lymphocytes: dependence on T-cell coreceptor and calcineurin signaling
    Anthony D Cristillo
    Laboratory of Lymphocyte Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 101:216-25. 2003
    ..Differential chemokine expression profiles result from the engagement of T-cell coreceptors and the requirement for, and the dependence on, calcineurin phosphatase activity...
  41. ncbi Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3
    A Ben-Baruch
    Laboratory of Molecular Immunoregulation, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Biol Chem 270:22123-8. 1995
    ..Since MCP3 has been reported to use MCP1 receptor(s), our results with transfected 293 cells expressing only C-C CKR1 clearly establish that C-C CKR1 is also a functional receptor for MCP3...
  42. ncbi CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
    L Wu
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    Nature 384:179-83. 1996
    ..These results suggest that HIV-1 attachment to CD4 creates a high-affinity binding site for CCR-5, leading to membrane fusion and virus entry...
  43. pmc Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophage-tropic HIV-1 isolate
    F C Verrier
    Département de Virologie Moléculaire, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 94:9326-31. 1997
    ....
  44. ncbi Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor
    G Bernardini
    Regina Elena Cancer Institute, Department of Experimental Medicine and Pathology, University of Rome, La Sapienza, Italy
    Eur J Immunol 28:582-8. 1998
    ..The pattern of CCR8 mRNA expression and the functional effects exerted by its ligand suggest that the triggering of this receptor may regulate multiple functions including activation, migration and proliferation of lymphoid cells...
  45. ncbi The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8
    C G Garlisi
    Allergy and Immunology, Schering Plough Research Institute, Kenilworth 07033 0539, USA
    Eur J Immunol 29:3210-5. 1999
    ..These data also provide a framework for suggesting minimum requirements for the assignment of chemokine receptor-ligand pairs...
  46. ncbi Macrophage inflammatory protein-1
    Patricia Menten
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B 3000, Leuven Belgium
    Cytokine Growth Factor Rev 13:455-81. 2002
    ....
  47. ncbi The binding surface and affinity of monomeric and dimeric chemokine macrophage inflammatory protein 1 beta for various glycosaminoglycan disaccharides
    Melissa A McCornack
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, USA
    J Biol Chem 278:1946-56. 2003
    ....
  48. ncbi Characterization of the role of the N-loop of MIP-1 beta in CCR5 binding
    Antoine Bondue
    IRIBHN, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, B 1070 Bruxelles, Belgium
    Biochemistry 41:13548-55. 2002
    ....
  49. pmc Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer
    Marlene Wolf
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Am J Pathol 162:1183-90. 2003
    ..cell lines MCF-7 and T47D, selectively degrade macrophage inflammatory protein (MIP)-1 alpha (CCL3), MIP-1 beta (CCL4), and SLC (CCL21)...
  50. ncbi HIV-1 Vpr and anti-inflammatory activity
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 23:239-47. 2004
    ..These activities are worthy of further examination for control of hyperinflammatory and hyperproliferative conditions...
  51. ncbi Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis
    Lucia Conti
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome 00161, Italy
    Immunobiology 209:99-115. 2004
    ..This paper provides an overview of the present knowledge on gp120 binding, signal transduction triggering and interference with macrophage and DC functions and it highlights the importance of this interaction in the pathogenesis of AIDS...
  52. pmc Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells
    Manuela Del Corno
    Istituto Superiore di Sanita, Department of Cell Biology and Neurosciences, Viale Regina Elena 299, 00161 Rome, Italy
    J Virol 79:12597-601. 2005
    ..type 1 or gp120, but not gp41, triggered alpha interferon (IFN-alpha), CC chemokine ligand 2 (CCL2), CCL3, and CCL4 production in human plasmacytoid dendritic cells (DCs) but not in myeloid DCs (M-DCs) or monocyte-derived DCs from ..
  53. ncbi HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection
    M Kaul
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Death Differ 14:296-305. 2007
    ..This finding suggests that CCR5 ligands can protect neurons at least, in part, by modulating CXCR4-mediated toxicity through heterologous desensitization...
  54. ncbi HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets
    Maria Giovanna Quaranta
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    FASEB J 21:2323-34. 2007
    ..Our findings suggest that the Nef-induced dysregulation in the DC/NK cell crosstalk may represent a potential mechanism through which HIV escapes innate immune surveillance...
  55. doi Increased serum monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta, and interleukin-8 concentrations in hemophagocytic lymphohistiocytosis
    Kazushi Tamura
    Department of Pediatrics and Developmental Medicine, Gunma University Graduate School of Medicine, Maebashi, Gumma, Japan
    Pediatr Blood Cancer 51:662-8. 2008
    ..We analyzed the serum concentrations of monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1beta, and interleukin (IL)-8 to investigate the roles of these chemokines in the pathophysiology of HLH...
  56. doi Prokineticin 1 induces CCL4, CXCL1 and CXCL8 in human monocytes but not in macrophages and dendritic cells
    Justin Monnier
    INSERM U620 Universite de Rennes 1, IFR140, Rennes, France
    Eur Cytokine Netw 19:166-75. 2008
    ..Our results show that only three chemokines (CCL4, CXCL1 and CXCL8) were significantly induced at both the transcript and protein level, and that PROK1 induces most ..
  57. pmc HIV-1 infection inhibits cytokine production in human thymic macrophages
    Tomasz Rozmyslowicz
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Exp Hematol 38:1157-66. 2010
    ..Macrophages represent one of the most important peripheral targets of HIV-1 infection, are resident in the thymic stroma, and play a central role in thymocyte maturation...
  58. pmc LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β release
    Anders Lundequist
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18192. 2011
    ..Recently GPR92/LPA5 was identified as an LPA receptor highly expressed by cells of the immune system, which prompted us to investigate its presence and influence on mast cells...
  59. ncbi A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry
    M Farzan
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 275:33516-21. 2000
    ..These data underscore the important role of the N-terminal sulfate moieties of CCR5 in the entry of R5 HIV-1 isolates and localize a critical contact between gp120 and CCR5...
  60. ncbi Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5
    G Franchin
    Picower Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 164:2592-601. 2000
    ..Taken together, our results suggest a novel pathway of CCR5 recycling in LPS-stimulated human macrophages that might be targeted to control HIV-1 infection...
  61. ncbi Biliary proliferation and adaptation in furan-induced rat liver injury and carcinogenesis
    A E Sirica
    Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0297, USA
    Toxicol Pathol 24:90-9. 1996
    ..hyperplastic bile ductule tissue at 3-5 days following the administration of a single hepatonecrogenic dose of CCl4 to rats that 4-6 wk earlier had been subjected to a bile duct ligation...
  62. ncbi Carbon tetrachloride-induced hepatotoxicity enhances the development of pulmonary foam cells in rats fed a cholesterol-cholic acid diet
    K Shibuya
    Nippon Institute for Biological Science, Tokyo, Japan
    Toxicol Pathol 25:487-94. 1997
    The effect of CCl4-hepatotoxicity on the development of pulmonary foam cells (PFCs) was studied using 4 groups of rats...
  63. ncbi Lipopolysaccharide from an Escherichia coli htrB msbB mutant induces high levels of MIP-1 alpha and MIP-1 beta secretion without inducing TNF-alpha and IL-1 beta
    D M Hone
    Division of Basic Science, Institute of Human Virology, Baltimore, Maryland 21201, USA
    J Hum Virol 1:251-6. 1998
    ..To identify a lipopolysaccharide (LPS) that retains the capacity to induce beta-chemokine secretion without the concomitant activation of pyrogenic cytokines...
  64. ncbi [The protective effect of hepatocyte growth-promoting factor (pHGF) against carbon tetrachloride-induced acute liver injury in rats. II. Protective effects on cell membrane injury]
    W Dai
    Department of Pathology and Central Institute for Electron Microscopic Researches, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 68:154-64. 2001
    To examine the protective effects of hepatocyte growth-promoting factor (pHGF) against carbon tetrachloride (CCl4) -induced acute liver injury in rats, the pathological changes were observed by light and electron microcopy, and the serum ..
  65. ncbi Colchicine antimitosis abolishes CCl4 autoprotection
    V C Rao
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216 4505
    Toxicol Pathol 19:597-606. 1991
    A subtoxic dose of CCl4 is known to destroy liver microsomal cytochrome P-450 and this is widely accepted as the mechanism of CCl4 autoprotection...
  66. ncbi Role of CC chemokines (macrophage inflammatory protein-1 beta, monocyte chemoattractant protein-1, RANTES) in acute lung injury in rats
    N M Bless
    Department of Trauma Surgery, University of Freiburg, Freiburg, Germany
    J Immunol 164:2650-9. 2000
    ..The findings suggest that in chemokine-dependent inflammatory responses in lung CC chemokines do not necessarily demonstrate redundant function...
  67. ncbi Comparison of acute hepatocellular proliferating cell nuclear antigen labeling indices and growth fractions, p34cdc2 kinases, and serum enzymes in carbon tetrachloride-treated rats
    T M Monticello
    Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Toxicol Pathol 23:439-46. 1995
    ..with cell proliferation immediately following insult with the classic hepatotoxicant carbon tetrachloride (CCl4)...
  68. ncbi Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of different cytotoxins on cytochrome P450 isoforms expression and on glycogen content
    A Lupp
    Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, Germany
    Exp Toxicol Pathol 52:381-93. 2000
    ..control rats were treated with different cytotoxins (allyl alcohol [AAL], bromobenzene [BBZ], carbon tetrachloride [CCl4], or thioacetamide [TAA]) or the respective solvents 24 or 48 hours before sacrifice...
  69. ncbi Identification of cell types producing RANTES, MIP-1 alpha and MIP-1 beta in rat experimental autoimmune encephalomyelitis by in situ hybridization
    R Miyagishi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    J Neuroimmunol 77:17-26. 1997
    ..Our observations support the possibility that chemokine production by T-cells, macrophages and astrocytes lead to the infiltration of inflammatory cells into the CNS parenchyma during the acute phase of EAE...
  70. ncbi Hepatocyte damage induced by carbon tetrachloride: inhibited lipoprotein secretion and changed lipoprotein composition
    M Boll
    Institute of Toxicology, GSF National Research Center for Environment and Health, , Neuherberg, Bundesrepublik Deutschland
    Z Naturforsch C 56:283-90. 2001
    Changes of lipoprotein secretion and composition in response to CCl4 treatment were studied in monolayer cultures of rat primary hepatocytes...
  71. ncbi [The role of nitric oxide in hyperdynamic circulation in portal hypertensive rats]
    Z Wu
    Department of Surgery, Renji Hospital, Shanghai Second Medical University, Shanghai 200001
    Zhonghua Wai Ke Za Zhi 36:182-6. 1998
    ..Sprague-Dawley rats were divided into four groups: intrahepatic portal hypertension (IHPH, n = 23) by injection of CCl4, prehepatic portal hypertension (PHPH, n = 26) by stenosis of the portal vein, end-to-side portacaval shunt (PCS, n ..
  72. ncbi Reversibility of rat liver cirrhosis by medroxyprogesterone acetate
    F Stenback
    Department of Pathology, University of Oulu, Finland
    Toxicol Pathol 17:38-45. 1989
    ..effects of a synthetic progesterone, medroxyprogesterone acetate (MPA), on carbon tetrachloride/phenobarbital (CCl4/PB)-induced rat liver injury were studied by morphological methods...
  73. ncbi Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: effects of various mitogens and cytotoxins on cytochrome P450 (P450) isoforms expression and on P450 mediated monooxygenase functions
    A Lupp
    Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, Germany
    Exp Toxicol Pathol 51:375-88. 1999
    ..and 2-acetylaminofluorene [AAF]) or cytotoxins (allyl alcohol [AAL], bromobenzene [BBZ] and carbon tetrachloride [CCl4]) or the respective solvents 24 or 48 hours before sacrifice...
  74. ncbi Expression of CC chemokines and their receptors in the eye in autoimmune anterior uveitis associated with EAE
    G Adamus
    Neurologic Sciences Institute, Oregon Health and Science University, Portland, USA
    Invest Ophthalmol Vis Sci 42:2894-903. 2001
    ..To determine the pattern of expression of CC chemokines and their receptors in the eyes of Lewis rats and to establish their role in autoimmune anterior uveitis (AU) associated with experimental autoimmune encephalomyelitis (EAE)...
  75. ncbi [Serum and cerebrospinal fluid concentration of inflammatory proteins MIP-1-alpha and MIP-1-beta and of interleukin 8 in the course of borreliosis]
    Sambor Grygorczuk
    Kliniki Chorób Zakaźnych i Neuroinfekcji Akademii Medycznej w Białymstoku
    Neurol Neurochir Pol 37:73-87. 2003
    ..The results indicate the induction of Il-8, MIP-1 alpha and MIP-1 beta synthesis in the course of neuroborreliosis and a decrease of their concentrations during 2 weeks of treatment, however, without reaching the normal values...
  76. ncbi Liver damaging effect of suramin in normal and carbon-tetrachloride treated rats
    B Szende
    1st Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary
    Toxicol Pathol 19:266-72. 1991
    Male Fischer 344 (F344) rats were treated with phenobarbital + carbon tetrachloride (CCl4) for 16 weeks to induce liver cirrhosis. Another group of rats received 50 mg/kg iv suramin once a week for 16 weeks...
  77. ncbi Protective effects of phenolic compounds on CCl4-induced toxicity in isolated rat hepatocytes
    M T Añón
    Departamento de Farmacologia, Facultad de Farmacia, Valencia, Spain
    Z Naturforsch C 47:275-9. 1992
    The protective effects of a series of phenolic compounds, phenolic acids and flavonoids on the cytotoxicity of CCl4 in rat hepatocytes were studied...
  78. ncbi Inhibition of microsomal lipid peroxidation and monooxygenase activities by eugenol
    E Nagababu
    Biochemistry Division, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad
    Free Radic Res 20:253-66. 1994
    ..of eugenol on microsomal mixed function oxidase mediated peroxidation using Fe+3-ADP-NADPH, carbon tetrachloride (CCL4)-NADPH and cumene hydroperoxide (CumOOH) systems...
  79. pmc Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis
    H L Weng
    Institute of Infectious Diseases, First Affiliated Hospital, Medical School, Zhejiang University, 261 Qingchun Lu, Hangzhou 310003, Zhejiang Province, China
    World J Gastroenterol 7:42-8. 2001
    ..To evaluate the antifibrotic effect of different doses of recombinant human Gamma-Interferon (IFN-gamma) in two rat models of hepatic fibrosis, and to observe its effect on moderate chronic hepatitis B virus fibrosis...
  80. ncbi Dysregulation of renal aquaporins and Na-Cl cotransporter in CCl4-induced cirrhosis
    P Fernandez-Llama
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Kidney Int 58:216-28. 2000
    ..Severe hepatic cirrhosis is associated with abnormal renal water retention...
  81. ncbi Time course of hepatic injury and recovery following coadministration of carbon tetrachloride and trichloroethylene in Fischer-344 rats
    D R Steup
    Department of Pharmacology and Toxicology, University of Arizona, College of Pharmacy, Tucson 85721
    Toxicol Pathol 21:327-34. 1993
    ..5 ml/kg, resulted in a marked potentiation of liver injury caused by an oral dose of carbon tetrachloride (CCl4, 0.05 ml/kg). Hepatic glutathione levels were depressed at 24 hr only in the rats given TCE and CCl4...
  82. pmc Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus
    Takashi Nakayama
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    J Virol 78:1665-74. 2004
    ..cells and regulatory T cells via CCR4, and also upregulated constitutive expression of MIP-1 alpha/CCL3, MIP-1 beta/CCL4, and RANTES/CCL5, which are known to attract Th1 cells and cytotoxic T cells via CCR5...
  83. ncbi Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 )
    Umayal Lakshmanan
    Cell Death and Human Diseases, Genomics and Genetics Division, Institute of Molecular and Cell Biology, Proteos, Singapore, Republic of Singapore
    J Immunol 179:8480-90. 2007
    ..exhibited substantially reduced LPS-induced secretion of several chemokines and cytokines, including IL-8 (CXCL8), CCL4 (macrophage-inflammatory protein-1beta), CCL20 (macrophage-inflammatory protein-3alpha), and IL-1beta...
  84. ncbi Evaluation of role of mast cells in the development of liver fibrosis using mast cell-deficient rats and mice
    A Sugihara
    Department of Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    J Hepatol 30:859-67. 1999
    ..In this study mast cell-deficient mutant Ws/Ws rats and W/Wv mice were used to examine whether mast cells are involved in the development of liver fibrosis...
  85. ncbi Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model
    Lutz W D Weber
    Institute of Toxicology, GSF National Research Center for Environment and Health, Munich, P O Box 1129, D 85758 Neuherberg FRG
    Crit Rev Toxicol 33:105-36. 2003
    The use of many halogenated alkanes such as carbon tetrachloride (CCl4), chloroform (CHCl3) or iodoform (CHI3), has been banned or severely restricted because of their distinct toxicity...
  86. pmc Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats
    Ru Tao Hong
    Department of Geriatrics Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
    World J Gastroenterol 15:1452-8. 2009
    To investigate the protective effects of melatonin on carbon tetrachloride (CCl4)-induced hepatic fibrosis in experimental rats.
  87. ncbi Role of hepatocellular regeneration in CCl4 autoprotection
    K N Thakore
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216 4505
    Toxicol Pathol 19:47-58. 1991
    The destruction of liver microsomal cytochromes P450 by a previously administered low dose of CCl4 has been widely accepted as the mechanism of CCl4 autoprotection...
  88. pmc A role for the divergent actin gene, ACT2, in nuclear pore structure and function
    C Yan
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    EMBO J 16:3572-86. 1997
    We have identified a temperature-sensitive allele of the yeast divergent actin gene ACT2, act2-1, which displays defects in nuclear pore complex (NPC) structure and nuclear import at the restrictive temperature...
  89. ncbi Elevated levels of MCP-1, MIP-alpha and MIP-1 beta in the bronchoalveolar lavage (BAL) fluid of patients with mustard gas-induced pulmonary fibrosis
    Ali Emad
    Department of Internal Medicine, Section of Pulmonary Diseases, Shiraz University of Medical Sciences, Shiraz, Iran
    Toxicology 240:60-9. 2007
    ..Role of chemokines in the pathogenesis of pulmonary fibrosis (PF) due to sulfur mustard (SM) gas inhalation...
  90. ncbi Actin-encoding cDNAs and gene expression during the intermolt cycle of the Bermuda land crab Gecarcinus lateralis
    K Varadaraj
    Biology Division, Oak Ridge National Laboratory, TN 37831, USA
    Gene 171:177-84. 1996
    Two actin-encoding cDNAs (act1 and act2) from Gecarcinus lateralis have been sequenced or partially sequenced and the corresponding proteins deduced...
  91. pmc Validation of internal control for gene expression study in soybean by quantitative real-time PCR
    Bo Jian
    School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China
    BMC Mol Biol 9:59. 2008
    ..Only a few studies on HKGs have been done in plants, and none in soybean, an economically important crop. Therefore, the present study was conducted to identify suitable HKG(s) for normalization of gene expression in soybean...
  92. ncbi Protection from chlordecone-amplified carbon tetrachloride toxicity by cyanidanol: regeneration studies
    M G Soni
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216 4505
    Toxicol Appl Pharmacol 108:58-66. 1991
    Previous work has shown that chlordecone (CD)-amplified CCl4 hepatotoxicity and lethality can be mitigated by pretreatment with cyanidanol...
  93. ncbi Physiologically based pharmacokinetic/pharmacodynamic modeling of the toxicologic interaction between carbon tetrachloride and Kepone
    H A el-Masri
    Department of Environmental Health, Colorado State University, Fort Collins 80523, USA
    Arch Toxicol 70:704-13. 1996
    Carbon tetrachloride (CCl4) lethality in Sprague-Dawley rats is greatly amplified by pretreatment of Kepone (decachlorooctahydro-1,3,2-metheno-2H-cyclobuta[cd] pentalen-2-one)...
  94. ncbi Divergent and synergistic regulation of matrix metalloprotease production by cytokines in combination with C-C chemokines
    V J Richardson
    Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Int J Immunopathol Pharmacol 23:715-26. 2010
    ..This study investigates the effects of four C-C chemokines, CCL2, CCL3, CCL4 and CCL5 either alone or in the presence of two regulatory cytokines TNF-alpha and TGF-beta and their effect on ..
  95. ncbi Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidants
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, P O Box 832, 163 Horreya Avenue, Alexandria, Egypt
    Toxicology 165:217-24. 2001
    ..The current study included two experiments. In the first experiment, animals received single oral dose of CCl4 (400 mg/kg body weight) after administration of AA (100 mg/kg b.w.), VE (100 mg/kg b.w.) or garlic (800 mg/kg b.w...
  96. ncbi Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines
    U Widmer
    Picower Institute for Medical Research, Manhasset, NY 11030
    J Immunol 150:4996-5012. 1993
    ....
  97. pmc Both vegetative and reproductive actin isovariants complement the stunted root hair phenotype of the Arabidopsis act2-1 mutation
    Laura U Gilliland
    Department of Genetics, University of Georgia, Athens, Georgia 30602 7223, USA
    Plant Physiol 130:2199-209. 2002
    The ACT2 gene, encoding one of eight actin isovariants in Arabidopsis, is the most strongly expressed actin gene in vegetative tissues...
  98. ncbi Effect of colchicine on hepatobiliary function in CCl4 treated rats
    C V Rao
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216 4505
    Biochem Pharmacol 42:2323-32. 1991
    ..p. in saline) pretreatment in rats 2 hr prior to the administration of a single low dose of CCl4 (100 microL/kg, i.p., in corn oil) or corn oil alone (1 mL/kg, i.p...
  99. pmc Induction of the chemokine beta peptides, MIP-1 alpha and MIP-1 beta, by lipopolysaccharide is differentially regulated by immunomodulatory cytokines gamma-IFN, IL-10, IL-4, and TGF-beta
    B Sherry
    Picower Institute for Medical Research, Manhasset, New York, USA
    Mol Med 4:648-57. 1998
    ..This altered pattern of secretion may explain, at least in part, the high circulating levels of MIP-1 beta relative to MIP-1 alpha observed in vivo in response to LPS challenge...
  100. doi Clinical importance of bronchoalveolar lavage fluid and blood cytokines, surfactant protein D, and Kerbs von Lungren 6 antigen in idiopathic pulmonary alveolar proteinosis
    Fang Chi Lin
    Department of Internal Medicine, Yang Ming Branch, Taipei City Hospital, Taipei, Taiwan
    Mayo Clin Proc 83:1344-9. 2008
    ....
  101. pmc Identification of act2, an essential gene in the fission yeast Schizosaccharomyces pombe that encodes a protein related to actin
    J P Lees-Miller
    Cold Spring Harbor Laboratory, NY 11724
    Proc Natl Acad Sci U S A 89:80-3. 1992
    ..pombe that encodes a distantly related member of the actin protein family, herein referred to as act2. In contrast to all other actins, the derived amino acid sequence reveals that act2 is 427 residues long and ..

Research Grants82

  1. Sanjoy Roychowdhury; Fiscal Year: 2014
    ..RIP3 is also induced in mouse liver in other models of hepatic injury including carbon tetrachloride (CCl4)- and ischemia/reperfusion-induced liver damage...
  2. Heather L Francis; Fiscal Year: 2015
    ..biliary damage (by apoptosis) induced by treatment with the hepatotoxin, carbon tetrachloride (CCl4)...
  3. Samuel M Goldman; Fiscal Year: 2014
    ..The chlorinated solvents tetrachloroethylene (PERC, perchloroethylene) and carbon tetrachloride (CCl4) were also associated...
  4. PROTECTION FROM ENVIRONMENTAL TOXINS/MUTAGENS BY INDOLES
    HOWARD SHERTZER; Fiscal Year: 1990
    ..I-3-C), and other indole compounds protect against hepatotoxicity resulting from exposure to carbon tetrachloride (CCl4) or N-nitrosodimethylamine (NDMA)...
  5. MECHANISMS OF HEPATOTOXICITY BY ENVIRONMENTAL POLLUTANTS
    Ronald Thurman; Fiscal Year: 1991
    ..Methods will be developed to measure rates of CCl4, aflatoxin and allyl alcohol metabolism, glutathione-S-conjugation and to monitor Ca++ concentrations in periportal ..
  6. TOXINS AND HEPATOCELLULAR PHOSPHOGLYCERIDE CATABOLISM
    ROBERT LAMB; Fiscal Year: 1990
    The hepatotoxicity of carbon tetrachloride (CCl4) is primarily a result of electrophilic metabolites such as the trichloromethyl radical (.CCl3). Yet, the mechanism(s) by which .CCl3 causes cell death are still unresolved...
  7. TOXIC LIVER INJURY: CA2+, PLA2, PROTEASES & EICONSANOIDS
    ERIC GLENDE; Fiscal Year: 1993
    ..Because the toxicity of CCl4 is greatly enhanced at low PO2, projected studies conducted at reduced PO2 should provide new data on the key ..
  8. THE INTERPLAY BETWEEN HEPATIC GROWTH AND METABOLISM
    Kim Olthoff; Fiscal Year: 2004
    ..and repair and explore mechanistic defects after partial hepatectomy, acute and chronic carbon tetrachloride (CCl4) mediated liver injury and FAS mediated liver injury...
  9. INDUCTION OF P21 AND P27 IN LIVER AFTER CCL4 INJURY
    ANGELA TYNER; Fiscal Year: 2005
    DESCRIPTION: Carbon tetrachloride (CCl4) induces liver injury, which involves many pathological processes. In response to injury, the liver has the unique ability to regenerate...
  10. REPLACEMENT OF SULFITE OXIDASE AFTER CC14 DAMAGE
    MICHAEL BRABEC; Fiscal Year: 1980
    ..amino acids into sulfite oxidase, and the synthesis of outer membrane phospholipids during the recovery from acute CCl4 exposure are under study to define the role of these processes in the recovery of the cell following damage induced ..
  11. The Role of Leptin in Liver Fibrogenesis
    Frank A Anania; Fiscal Year: 2012
    ..We will use Ad -/- mice subjected to either CCl4 or common bile-duct ligation (CBDL) for induction of fibrosis and administer recombinant adiponectin...
  12. The Role of Fibrocytes in Liver Fibrosis
    Tatiana Kisseleva; Fiscal Year: 2012
    ..of inflammatory signals in the course of liver fibrosis using two models of liver injury, carbontetrachloride (CCl4 and bile duct ligation (BDL)...
  13. Frank A Anania; Fiscal Year: 2016
    ..Preliminary data indicate that while CCl4 treated adiponectin knock-out mice develop FAs as assessed by immunofluorescence, adenoviral delivery of ..
  14. Yedidya Saiman; Fiscal Year: 2014
    ..in promoting hepatic fibrosis and inflammation in mechanistically distinct mouse models of liver injury (BDL and CCl4) by blocking the SDF-11/CXCR4 (SDF-11 neutralizing antibody or CXCR4 small molecule inhibitor)...
  15. Protection of Oxidant Toxicity by GSTs
    YOGESH CHANDRA AWASTHI; Fiscal Year: 2010
    ..tested through proposed in-vitro studies using HepG2 cells transfected with Cyp2E1 and two model oxidant compounds, CCl4, and doxorubicin (DOX)...
  16. Joseph D Locker; Fiscal Year: 2016
    ..In addition, we will assess the utility of HNF4[unreadable]-AAV treatment during continuing injury with CCL4 to determine the potential clinical efficacy of such therapy...
  17. GIANFRANCO D ALPINI; Fiscal Year: 2016
    ..mechanism via activation of cAMP-dependent signaling;(ii) secretin is an autocrine protective factor against CCl4-induced damage of large cholangiocytes;(iii) in vivo (in KO mouse models) and in vitro (in small and large ..
  18. Lester F Lau; Fiscal Year: 2016
    ..recent study has shown that activated hepatic stellate cells, which are the major source of extracellular matrix in CCl4-induced liver injury, undergo cellular senescence...
  19. Toll-Like Receptor Signaling in Hepatic Fibrogenesis
    Robert F Schwabe; Fiscal Year: 2012
    ..Using bile duct ligation and CCl4 treatment as models of experimental fibrogenesis, we will define the contribution of TLR2, TLR4 and TLR9 to hepatic ..
  20. Kinji Asahina; Fiscal Year: 2015
    ..data support that MCs migrate inward and differentiate into myofibroblasts during liver fibrosis induced by CCl4 or alcohol treatment in mice...
  21. The Role of Complement in Liver Regeneration
    John Lambris; Fiscal Year: 2005
    ..and dissect the mechanism(s) of its involvement in an in vivo model of partial hepatectomy and a model of CCl4-toxic injury, using mice deficient in complement components as well as various molecular and immunohistochemical ..
  22. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..Additionally, chemokines (CCL3/MIP-11, CCL4/MIP-12, CXCL9/MIG, CXCL10/IP-10, CXCL12/SDF, and CCL5/RANTES) within these tissues will be examined to determine ..
  23. Wei Jen Tang; Fiscal Year: 2015
    ..A?, and other functionally relevant substrates such as natriuretic peptides and proinflammatory chemokines, CCL3/CCL4. IDE has two 55 kDa domains, which form an enclosed catalytic chamber to entrap its substrates...
  24. In Vivo Brain Dialysis of Neuropeptides and Neuroimmune Signaling Proteins
    Julie A Stenken; Fiscal Year: 2012
    ..be on a select group of cytokines and neuropeptides related to epilepsy (cytokines {CCL2 [MCP-1], CCL3 [MIP-1a], CCL4 [MIP-12], CCL5 [RANTES], KC/GRO, IL-1b, IL-6, IL-10, and TNF-a} and neuropeptides {angiotensin IV, 2-amyloid, ..
  25. Interaction of cationic lipids with dendritic cells
    Leaf Huang; Fiscal Year: 2012
    ..pERK activation leads to the production and the secretion of potent chemokines, CCL2 and CCL4, by BMDC. P38 activation leads to the production of IL-12...
  26. ALEX YEE CHEN HUANG; Fiscal Year: 2015
    ..Using animal tumor models genetically engineered to secrete inflammatory chemokines such as CCL3 and CCL4, we propose to undertake a series of studies to investigate how efficient cell-cell interaction among tumor-..
  27. Patrick M Stuart; Fiscal Year: 2014
    ..hypotheses we will: (1) Determine the role that the proinflammatory molecules IL-6, KC (IL-8), IP10 (CXCL10), and CCL4 play in recurrent HSK disease pathogenesis...
  28. Inflammatory Mediators of Prostate Cancer Metastasis and Responses to Curcumin
    Magaly Martinez-Ferrer; Fiscal Year: 2013
    ..In a nested case control study, CX3CL1, IL-15, and CCL4 expression were independent predictors of recurrence status...
  29. mtDNA mutation/heteroplasmy: a sensitive functional biomarker of oxidative stress
    Bruce N Ames; Fiscal Year: 2010
    ..These effects will be compared to CCl4 stress, which was the oxidative stress utilized in the NIHinitiated multi-center BOSS study using the common ..
  30. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    Jianming Tang; Fiscal Year: 2012
    ..genes in the pathway for expression of the HIV-1 chemokine co-receptor and its ligands (CCR2, CCR5, CCL3, CCL3L1, CCL4, CCL4L1, and CCL5). Related new candidate genes will be considered...
  31. LIPID PEROXIDATION\CELL SIGNALING-CC14-INDUCED FIBROSIS
    DENNIS PETERSEN; Fiscal Year: 2004
    ..in 3 specific aims using hepatic nonparenchymal and parenchymal cells isolated form rat during the progression of CCl4-induced cirrhosis...
  32. HIV, Chemokine Receptors, and Vascular Smooth Muscle
    ALISON SCHECTER; Fiscal Year: 2007
    ..Macrophage inflammatory protein-1 beta (MIP-1beta, CCL4) and stromal cell-derived protein (SDF-1, CXCL12) are the endogenous ligands for CCR5 and CXCR4, respectively...
  33. EFFECTS OF DIETARY FAT ON LIPID PEROXIDATIVE INJURY
    Jeffrey Beckman; Fiscal Year: 1992
    ..and measuring microsomal peroxidation products generated in vitro (by reduced iron) and in vivo (by CCL4)...
  34. CHEMOKINE SECRETING CD8 T CELL SUBSETS IN HIV INFECTION
    Fiorenza Cocchi; Fiscal Year: 1999
    ..Correlation of the magnitude of any observed impairment with disease progression will validate the hypothesis. ..
  35. CD8+ T CELLS IN PRIMARY INFECTION
    Roberta Kamin Lewis; Fiscal Year: 1999
    ..After acute HIV infection they have found that a subset of T cells arises spontaneously that secretes MIP 1 beta and is also characterized by being gamma interferon negative...
  36. MODIFICATION OF BILIARY EXCRETION BY TOXIC CHEMICALS
    HARIHARA MEHENDALE; Fiscal Year: 1980
    ..all three compounds are capable of inducing hepatic dysfunction, only Kepone is extremely potent in potentiating CCl4 hepatotoxicity which is manifested as totally disrupted hepatic function and hepatocellular necrosis at very low, ..
  37. Role of cytokines in retroviral neuropathogenesis
    Karin Peterson; Fiscal Year: 2005
    ..Therefore, we will also analyze how infected microglia cells regulate TNF alpha and MCP-1production, in vivo. ..
  38. XENOBIOTIC REGULATED TURNOVER OF CYTOCHROMES P450
    Amit Banerjee; Fiscal Year: 2004
    ..To date, only ubiquitination of CCl4-damaged CYP2E1 has been reported...
  39. MECHANISMS FOR TNF ALPHA IN XENOBIOTIC LIVER INJURY
    Mark Rutherford; Fiscal Year: 2000
    ..Liver histopathology will be evaluated in TNFR deficient mice exposed to CCl4 acetaminophen, cadmium, and chlorinated hydrocarbons to determine whether neutralization of specific TNF-a signals ..
  40. IN VIVO ASSAY OF ENVIRONMENTAL TOXINS WITH MR MICROSCOPY
    G Johnson; Fiscal Year: 1993
    ..Technical efforts will be directed at three specific models of liver toxicity; (a) CCl4-induced fibrosis, (b) bile-duct hyperplasia induced with alpha-naphthylisothiocyanate (ANIT), and (c) foci of ..
  41. Organ Specific Damage Assessment Biomarker Assays
    Thomas Brown; Fiscal Year: 2005
    ..several such damage biomarkers in serum derived from both lung and liver after administration of ozone and CCl4. Having demonstrated proof of concept in Phase I, in Phase II we propose to expand our studies to multiple organ ..
  42. Liver Fibrosis, Inflammation & Oxidative Stress Markers
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  43. MECHANISM AND ROLE OF MICROSOMAL ETHANOL OXIDATION
    Charles Lieber; Fiscal Year: 2001
    ..Such information is aimed at elucidating key aspects of alcohol mediated pathology in a way which may eventually affect alcohol related medical complications, their prevention and treatment. ..
  44. DLPC Treatment of Alcoholic and Non-Alcoholic Fibrosis
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  45. ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERS
    Charles Lieber; Fiscal Year: 2005
    ..Funds are requested for special laboratory tests, study nurses, travel to meetings, patient monitoring expenses and a core office. ..
  46. Migration of Mature and Immature Dendritic Cells
    HENDRIK VAN DEVENTER; Fiscal Year: 2006
    ..All have extensive experience in developing the careers o f young scientists. This work has the support of the Lineberger Comprehensive Cancer Center which has made accessible its core facilities. ..
  47. Synergistic Nutraceutical Effects of DLPC and SAMe
    Charles Lieber; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  48. Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol Drinkers
    Charles Lieber; Fiscal Year: 2007
    ..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. [unreadable] [unreadable]..
  49. Screening for Novel Modulators of Notch/RBPjk Interactions
    MA XENIA ILAGAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  50. Sphingosine Phosphate Role in Inflammation
    Lina Obeid; Fiscal Year: 2009
    ..These studies will enable us to gain important insight into the role of this pathway in inflammatory responses and may also provide novel therapeutic approaches to inflammation. ..
  51. Immune Responses During Measles Virus Infection
    Diane Griffin; Fiscal Year: 2007
    ..3. To determine the roles of different CD4 and CD8 T cell populations in production of cytokines at various times during measles and the effect of concurrent HIV infection on these roles. ..
  52. Environmental Hormones: Effects on Thyroid Function
    Curtis Klaassen; Fiscal Year: 2005
    ..abstract_text> ..
  53. LIVER REPOPULATION FOR LIVER INJURY AND GENE THERAPY
    Sanjeev Gupta; Fiscal Year: 2008
    ..Completion of our studies will generate new knowledge in liver repopulation and cell and gene therapy mechanisms. This will lead to more effective liver-directed cell and gene therapy in people. ..
  54. Coordinate Regulation of Uptake and Efflux Transporters
    Curtis D Klaassen; Fiscal Year: 2010
    ....
  55. Elucidating Biopsychosocial Mediators of HIV Progression
    LYDIA TEMOSHOK; Fiscal Year: 2009
    ....
  56. Molecular Mechanism of Acupuncture
    Gabriela Garcia; Fiscal Year: 2006
    ..We believe that our studies may open new era towards molecular understanding of acupuncture treatment in pain, inflammation, as well as a variety of vascular diseases in humans. ..
  57. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  58. Regulation of Hepatic Excretion of Xenobiotics by Mrps
    Curtis D Klaassen; Fiscal Year: 2010
    ..Elucidation of the role of Nrf2 in the regulation of the efflux transport process will have significant ramifications in toxicology, xenobiotics disposition, drug-drug interaction, and cancer chemoprevention. ..
  59. Chemokine Receptor Signaling in HIV Neuropathology
    Marcus Kaul; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. The Role of CD4 on Natural Killer Cells
    HELENE BERNSTEIN; Fiscal Year: 2006
    ....
  61. IMMUNOLOGICAL MECHANISM OF INFLAMMATION IN UVEITIS & EAE
    Grazyna Adamus; Fiscal Year: 2001
    ..3) Examine the role of cytokines and chemokines in the recruitment of cell to the eye in primary and recurrent uveitis associated with EAE after immunization of Lewis rats with MBP. ..
  62. Neurocognitive Effects of HCV, HIV, and Drug Use
    Scott Letendre; Fiscal Year: 2004
    ..The findings of this research will be used to evaluate the feasibility of an interventional study, and to assist in its design. ..
  63. HEPATOBILIARY DISPOSITION IN TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 2003
    ..abstract_text> ..
  64. IL-6 regulation of matrix degradation in liver fibrosis
    Meena Bansal; Fiscal Year: 2006
    ..Understanding these mechanisms will provide the basis for the development of novel anti-fibrotic therapies to treat a widely prevalent disease for which there is no effective treatment to date. ..
  65. Communication between Kupffer cells and stellate cells
    Natalia Nieto; Fiscal Year: 2009
    ..We hope that this co-culture model will help us to define the effects of Kupffer cells on the stellate cell fibrogenic response and to dissect potential therapeutic targets for preventing liver disease. ..
  66. A Dual Electrospray/Photoionization Source
    JACK SYAGE; Fiscal Year: 2008
    ..There is already interest in this technology by commercial MS vendors. If we are successful with the Phase II work, we are confident of finding a commercialization partner for the ES/PI source. ..
  67. Dendrimer aminosaccharide drug to modulate inflammatory responses in shigellosis
    Sunil Shaunak; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  68. RNA editing and its inhibition of HIV-1 replication in human macrophage
    Yoshihiko Hoshino; Fiscal Year: 2007
    ..These studies will establish if ADAR1 impacts on viral replication and mutation and will be the basis of further investigation on the impact of drug abuse on the expression of ADAR1. [unreadable] [unreadable] [unreadable]..
  69. Effects of Retinoic Acid and Acetaldehyde on Collagen
    Lan Wang; Fiscal Year: 2005
    ..It is an essential part of the structured career development plan, to extend Dr. Wang's knowledge and to further develop her skills, leading to an independent academic career. ..
  70. Recombinant T-cell Receptor Ligands for Treatment of Uveitis
    Grazyna Adamus; Fiscal Year: 2006
    ..To determine an effective treatment regimen for clinical rat AAU using RTLs. 2. To determine the abilities of RTLs to inhibit recurrent anterior and posterior uveitis in Lewis rats. [unreadable] [unreadable] [unreadable] [unreadable]..
  71. Effect of HIV-1 Vpr on Basic Cellular Functions (II)
    Richard Zhao; Fiscal Year: 2007
    ..abstract_text> ..
  72. IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASES
    Zahra Toossi; Fiscal Year: 2001
    ..3. To characterize the T-cell dysfunction of patients with active pulmonary tuberculosis, its relationship to TGF-beta and other suppressive cytokines (IL-10) and its reversal by inhibitors of TGF- beta. ..
  73. MEASLES VACCINES--IMMUNE RESPONSES AND ATYPICAL MEASLES
    Diane Griffin; Fiscal Year: 2001
    ....
  74. Infectious Diseases of the Nervous System: Pathogenesis and Worldwide Impact
    Diane Griffin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  75. ACUTE ALPHAVIRAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 2008
    ..abstract_text> ..
  76. LIVER RESPONSE TO LPS--ROLE OF LBP AND CD14
    Grace Su; Fiscal Year: 2003
    ..II. Determine the mechanism by which LBP and CD14 accelerate ingestion of Gram-negative bacteria. III. Determine the mechanisms by which LBP/CD14 mediated KC activation promote bacterial killing. ..
  77. Microwave-Assisted Electrospray Ionization for LC/MS
    JACK SYAGE; Fiscal Year: 2008
    ..Finally this project has the potential for explosive commercial growth, which will stimulate economic development. [unreadable] [unreadable] [unreadable]..
  78. Mitochondrial Ceramide in Chemotherapy-induced Apoptosis
    Lina M Obeid; Fiscal Year: 2010
    ..These studies will set the stage for pre-clinical development of these molecules and will establish mito-ceramides as potential novel chemotherapeutic agents. ..
  79. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  80. LIVER REPOPULATION FOR LIVER INJURY AND GENE THERAPY
    Sanjeev Gupta; Fiscal Year: 2007
    ..Our studies will provide valuable preclinical information for eventual applications of cell therapy in people. ..
  81. Cell Cycle G2/M Pathway Modulated by Viral Protein R
    Richard Zhao; Fiscal Year: 2006
    ..These proposed studies will provide a comprehensive framework for this new cell cycle control pathway and provide insights into fundamental aspects of this new G2/M surveillance system of eukaryotic cells. ..