CCL3L1

Summary

Gene Symbol: CCL3L1
Description: C-C motif chemokine ligand 3 like 1
Alias: 464.2, D17S1718, G0S19-2, LD78, LD78-beta(1-70), LD78BETA, MIP1AP, SCYA3L, SCYA3L1, C-C motif chemokine 3-like 1, G0/G1 switch regulatory protein 19-2, chemokine (C-C motif) ligand 3-like 1, small inducible cytokine A3-like 1, tonsillar lymphocyte LD78 beta protein
Species: human

Top Publications

  1. ncbi CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection
    W Shao
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Genes Immun 8:224-31. 2007
  2. pmc Chemokine expression patterns in the systemic and genital tract compartments are associated with HIV-1 infection in women from Benin
    Julie Lajoie
    Laboratoire d Immunogénétique, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Canada
    J Clin Immunol 30:90-8. 2010
  3. doi Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection
    M Paximadis
    AIDS Virus Research Unit, National Institute for Communicable Diseases, and Department of Virology, University of the Witwatersrand, Johannesburg, South Africa
    Int J Immunogenet 36:21-32. 2009
  4. pmc Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q
    S G Irving
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Nucleic Acids Res 18:3261-70. 1990
  5. ncbi LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity
    R J Nibbs
    Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD Scotland, United Kingdom
    J Biol Chem 274:17478-83. 1999
  6. ncbi Enhanced anti-HIV-1 activity of CC-chemokine LD78beta, a non-allelic variant of MIP-1alpha/LD78alpha
    X Xin
    Department of Viral Infection, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    FEBS Lett 457:219-22. 1999
  7. ncbi Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist
    P Proost
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Blood 96:1674-80. 2000
  8. ncbi CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12
    William S Modi
    Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Genomics 83:735-8. 2004
  9. ncbi The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility
    Enrique Gonzalez
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Science 307:1434-40. 2005
  10. pmc Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease
    Jane C Burns
    Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla 92093 0830, USA
    J Infect Dis 192:344-9. 2005

Scientific Experts

Detail Information

Publications116 found, 100 shown here

  1. ncbi CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection
    W Shao
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Genes Immun 8:224-31. 2007
    ..non-allelic isoforms encoded by different genes, namely chemokine (C-C motif) ligand 3 (CCL3), CCL4, CCL3-like 1 (CCL3L1) and CCL4L1. The products of these genes and of CCL5 (encoding RANTES, i.e...
  2. pmc Chemokine expression patterns in the systemic and genital tract compartments are associated with HIV-1 infection in women from Benin
    Julie Lajoie
    Laboratoire d Immunogénétique, Centre de recherche du Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Canada
    J Clin Immunol 30:90-8. 2010
    ..Understanding the genital mucosal immunity and the factors involved in linking innate to adaptive immunity is crucial for the design of efficient preventive strategies against human immunodeficiency virus (HIV)-1...
  3. doi Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection
    M Paximadis
    AIDS Virus Research Unit, National Institute for Communicable Diseases, and Department of Virology, University of the Witwatersrand, Johannesburg, South Africa
    Int J Immunogenet 36:21-32. 2009
    ..We thus propose Hap-A1 as a likely candidate for influencing levels of CCL3 production and in turn outcomes of HIV-1 infection...
  4. pmc Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q
    S G Irving
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Nucleic Acids Res 18:3261-70. 1990
    ..These genes are all located on chromosome 17 in bands q11-q21, the region implicated in von Recklinghausen neurofibromatosis (NF1) and in acute promyelocytic leukemia (AML-M3)...
  5. ncbi LD78beta, a non-allelic variant of human MIP-1alpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity
    R J Nibbs
    Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD Scotland, United Kingdom
    J Biol Chem 274:17478-83. 1999
    ..Here we show that a non-allelic isoform of human MIP-1alpha (LD78alpha), termed LD78beta or MIP-1alphaP, has enhanced receptor binding affinities to CCR5 (approximately 6-fold) and the promiscuous beta-..
  6. ncbi Enhanced anti-HIV-1 activity of CC-chemokine LD78beta, a non-allelic variant of MIP-1alpha/LD78alpha
    X Xin
    Department of Viral Infection, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    FEBS Lett 457:219-22. 1999
    We compared the anti-HIV-1 activity of CC-chemokine LD78beta with that of MIP-1alpha, another CC-chemokine which shows 94% sequence homology with LD78beta...
  7. ncbi Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist
    P Proost
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Blood 96:1674-80. 2000
    ..However, CD26/DPP IV cleaved LD78beta, a most potent CCR5 binding chemokine and inhibitor of macrophage tropic human immunodeficiency virus-1 (HIV-1) ..
  8. ncbi CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12
    William S Modi
    Basic Research Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702 1201, USA
    Genomics 83:735-8. 2004
    ..2-q12 on genomic contig NT_010799.13. Four of these genes comprise two closely related paralogous pairs: CCL3-CCL3L1 and CCL4-CCL4L1...
  9. ncbi The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility
    Enrique Gonzalez
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, and Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Science 307:1434-40. 2005
    ..and interpopulation differences in the copy number of a segmental duplication encompassing the gene encoding CCL3L1 (MIP-1alphaP), a potent human immunodeficiency virus-1 (HIV-1)-suppressive chemokine and ligand for the HIV ..
  10. pmc Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease
    Jane C Burns
    Department of Pediatrics, University of California at San Diego School of Medicine, La Jolla 92093 0830, USA
    J Infect Dis 192:344-9. 2005
    ..haplotypes was significantly greater in individuals who also possessed a high copy number of the gene encoding CCL3L1, the most potent CCR5 ligand...
  11. ncbi Copy number variations of CCL3L1 and long-term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia
    Toshiaki Nakajima
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    Immunogenetics 59:793-8. 2007
    ..In this study, we investigated the impacts of the CCL3L1 dose on the long-term prognosis in the subjects with chronic HIV-1 infection...
  12. ncbi CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms
    Matthew J Dolan
    Infectious Disease Clinical Research Program, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas 78236, USA
    Nat Immunol 8:1324-36. 2007
    ..Here we demonstrate that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both healthy and HIV-infected individuals...
  13. pmc CCL3L1 gene-containing segmental duplications and polymorphisms in CCR5 affect risk of systemic lupus erythaematosus
    M Mamtani
    The Veterans Administration Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System and Department of Medicine, University of Texas Health Science Center at San Antonio, Texas 78229 7870, USA
    Ann Rheum Dis 67:1076-83. 2008
    ..CC chemokine ligand 3 like-1 (CCL3L1) is a potent ligand for the HIV coreceptor, CC chemokine receptor 5 (CCR5), and we have demonstrated previously an ..
  14. pmc Host CCL3L1 gene copy number in relation to HIV-1-specific CD4+ and CD8+ T-cell responses and viral load in South African women
    Sharon Shalekoff
    AIDS Virus Research Unit, National Institute for Communicable Diseases, Johannesburg, South Africa
    J Acquir Immune Defic Syndr 48:245-54. 2008
    ..Because CCL3 has immune modulatory and antiviral activities, we hypothesized that host CCL3 genotype (CCL3L1 gene duplications) would influence the development of effective HIV-specific immune responses...
  15. pmc CCL3L1-CCR5 genotype improves the assessment of AIDS Risk in HIV-1-infected individuals
    Hemant Kulkarni
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, Texas, United States of America
    PLoS ONE 3:e3165. 2008
    ..markers are influenced, in part, by polymorphisms in CCR5, the major HIV coreceptor, and the gene copy number of CCL3L1, a potent CCR5 ligand and HIV-suppressive chemokine...
  16. pmc Role of CCL3L1-CCR5 genotypes in the epidemic spread of HIV-1 and evaluation of vaccine efficacy
    Hemant Kulkarni
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, San Antonio, Texas, USA
    PLoS ONE 3:e3671. 2008
    Polymorphisms in CCR5, the major coreceptor for HIV, and CCL3L1, a potent CCR5 ligand and HIV-suppressive chemokine, are determinants of HIV-AIDS susceptibility...
  17. pmc Combinatorial content of CCL3L and CCL4L gene copy numbers influence HIV-AIDS susceptibility in Ukrainian children
    Ludmila Shostakovich-Koretskaya
    Department of General Pediatrics and Pediatric Infectious Diseases, Dnepropetrovsk State Medical Academy, Dnepropetrovsk, Ukraine
    AIDS 23:679-88. 2009
    ..Copy number variation of CCL3L associates with HIV-AIDS susceptibility. Here, we determined the influence of the combinatorial content of distinct CCL3L and CCL4L genes on HIV-AIDS susceptibility...
  18. doi Association of copy number variation in the FCGR3B gene with risk of autoimmune diseases
    M Mamtani
    The Veterans Administration Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System and Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 7870, USA
    Genes Immun 11:155-60. 2010
    ..with the risk of developing autoimmune diseases and whether the observed associations are modified by the CNV in CCL3L1 (CC chemokine ligand 3-like 1), a gene encoding a potent chemokine...
  19. doi Association of CCR5-59029 A/G and CCL3L1 copy number polymorphism with HIV type 1 transmission/progression among HIV type 1-seropositive and repeatedly sexually exposed HIV type 1-seronegative North Indians
    Anurag Rathore
    Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    AIDS Res Hum Retroviruses 25:1149-56. 2009
    ..Therefore, we investigated the impact of CCR5 59029 A/G and CCL3L1 copy number polymorphism on HIV-1 disease susceptibility and progression among HIV-1-infected and HIV-1-exposed ..
  20. doi Lower copy numbers of the chemokine CCL3L1 gene in patients with chronic hepatitis C
    Frank Grunhage
    Department of Medicine II, Saarland University Hospital, Saarland University, Homburg, Germany
    J Hepatol 52:153-9. 2010
    ..determine the influence of copy number variation on the susceptibility and disease severity in hepatitis C virus (HCV) infection, investigating copy number variants (CNVs) of the chemokine CCL3L1 gene, which encodes a potent CCR5 ligand.
  21. pmc Association of CCR2-CCR5 haplotypes and CCL3L1 copy number with Kawasaki Disease, coronary artery lesions, and IVIG responses in Japanese children
    Manju Mamtani
    South Texas Veterans Health Care System and Department of Medicine, The Veterans Administration Center for AIDS and HIV 1 Infection, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 5:e11458. 2010
    ..Polymorphisms in CC chemokine receptor 5 (CCR5) and/or its potent ligand CCL3L1 influence KD susceptibility in US, European and Korean populations...
  22. pmc Copy number variation in chemokine superfamily: the complex scene of CCL3L-CCL4L genes in health and disease
    R Colobran
    Laboratory of Immunobiology for Research and Application to Diagnosis LIRAD, Tissue and Blood Bank BST, Institut d Investigació en Ciències de la Salut Germans Trias i Pujol IGTP Servei d Immunologia, Centre de Diagnostic Biomedic CDB, Hospital Clinic, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Clin Exp Immunol 162:41-52. 2010
    ..CCL3L2 was considered previously as a CCL3L1 pseudogene, but is actually transcribed...
  23. pmc CCL3L1 copy number variation and susceptibility to HIV-1 infection: a meta-analysis
    Sijie Liu
    The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 5:e15778. 2010
    Although several studies have investigated whether CCL3L1 copy number variation (CNV) influences the risk of HIV-1 infection, there are still no clear conclusions...
  24. pmc Influence of variations in CCL3L1 and CCR5 on tuberculosis in a northwestern Colombian population
    Manju Mamtani
    The Veterans Administration Center for AIDS and HIV 1 infection and Center for Personalized Medicine, South Texas Veterans Health Care System and Department of Medicine, University of Texas Health Science Center, San Antonio, USA
    J Infect Dis 203:1590-4. 2011
    ..in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia...
  25. pmc Functional effects of CCL3L1 copy number
    D Carpenter
    Centre for Genetics and Genomics and School of Biology, University of Nottingham, Nottingham, UK
    Genes Immun 13:374-9. 2012
    ..Here, we present data exploring the functional consequences of CNV of CCL3L1 in 55 independent UK samples with no known clinical phenotypes...
  26. doi CCL3L gene copy number and survival in an HIV-1 infected Zimbabwean population
    Margit Hørup Larsen
    Department of Clinical Immunology, Copenhagen University Hospital, Denmark
    Infect Genet Evol 12:1087-93. 2012
    ..9), viral load (P=0.9), or CCL3 protein levels (P=1.0). Survival among the HIV infected individuals did not differ according to CCL3L copy number. In this cohort, CCL3L CNV did not affect HIV status, pathogenesis, or survival...
  27. pmc CCL3L1 copy number and susceptibility to malaria
    Danielle Carpenter
    Centre for Genetics and Genomics, School of Biology, University of Nottingham, Nottingham NG7 2UH, UK
    Infect Genet Evol 12:1147-54. 2012
    ..Here we present the first study to investigate copy number variation of the chemokine gene CCL3L1 with susceptibility to malaria...
  28. doi Correlating multiallelic copy number polymorphisms with disease susceptibility
    Stuart Cantsilieris
    Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Melbourne, Victoria, Australia
    Hum Mutat 34:1-13. 2013
    ..been described for several genes, including the β-defensins (DEFB4, DEFB103, DEFB104), chemokine ligand 3 like 1 (CCL3L1), Fc gamma receptor 3B (FCGR3B), and complement component C4 (C4)...
  29. ncbi Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils
    S Struyf
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Eur J Immunol 31:2170-8. 2001
    Recently, the LD78beta isoform of the CC chemokine macrophage inflammatory protein (MIP)-1alpha was shown to efficiently chemoattract lymphocytes and monocytes and to inhibit infection of mononuclear cells by R5 HIV-1 strains...
  30. ncbi Gene copy number regulates the production of the human chemokine CCL3-L1
    Jane R Townson
    Cancer Research UK Beatson Laboratories, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland, UK
    Eur J Immunol 32:3016-26. 2002
    ..As a result of these studies, we hypothesize that genetic variation in CCL3-L1 gene copy number may affect the susceptibility to, or the progression or severity of, diseases in which this chemokine plays a role...
  31. pmc CCL3L1 copy number is a strong genetic determinant of HIV seropositivity in Caucasian intravenous drug users
    Kristi Huik
    Department of Microbiology, Faculty of Medicine, University of Tartu, 50411 Tartu, Estonia
    J Infect Dis 201:730-9. 2010
    A high copy number of CCL3L1, the most potent human immunodeficiency virus (HIV)-suppressive chemokine, associates with reduced HIV susceptibility...
  32. ncbi New developments in anti-HIV chemotherapy
    E De Clercq
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Curr Med Chem 8:1543-72. 2001
    ..e. AMD3100), polyphemusins (T22), TAK-779, MIP-1 alpha LD78 beta isoform]; (iii) virus-cell fusion, through binding to the viral glycoprotein gp41 [T-20 (DP-178), T-1249 (DP-..
  33. doi The relative activity of "function sparing" HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property?
    Vanessa M Muniz-Medina
    Infectious Diseases Discovery Performance Unit, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 75:490-501. 2009
    ..cells and peripheral blood mononuclear cells (PBMC)] and antagonists of chemokine (C-C motif) ligand 3-like 1 [CCL3L1]-mediated internalization of CCR5...
  34. ncbi A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes
    K Hieshima
    Department of Biochemistry, Kumamoto University Medical School, Japan
    J Immunol 159:1140-9. 1997
    ..with significant sequence identity to the human CC chemokine macrophage-inflammatory protein-1 alpha (MIP-1 alpha)/LD78 alpha...
  35. doi Radiolytic degradation of atrazine aqueous solution containing humic substances
    A A Basfar
    Radiation Technology Center, Atomic Energy Research Institute, King Abdulaziz City for Science and Technology, P O Box 6086, Riyadh 11442, Saudi Arabia
    Ecotoxicol Environ Saf 72:948-53. 2009
    ..The radiolytic degradation by-products and their mass balances were qualitatively determined with good confidence using gas chromatography/quadruple mass spectrometry (GC/MS) with electron impact ionization (EI(+)) mode...
  36. ncbi BB-10010: an active variant of human macrophage inflammatory protein-1 alpha with improved pharmaceutical properties
    M G Hunter
    British Biotech Pharmaceuticals Ltd, Oxford, UK
    Blood 86:4400-8. 1995
    The stem cell inhibitor, macrophage inflammatory protein-1 alpha (MIP-1 alpha) or LD78, protects multipotent hematopoietic progenitors in murine models from the cytotoxic effects of chemotherapy...
  37. pmc African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapine
    Louise Kuhn
    Gertrude H Sergievsky Centre, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    AIDS 21:1753-61. 2007
    Individuals with more copies of CCL3L1 (CCR5 ligand) than their population median have been found to be less susceptible to HIV infection...
  38. pmc Chemokine gene transfection into tumour cells reduced tumorigenicity in nude mice in association with neutrophilic infiltration
    K Hirose
    Biomedical Research Institute, Kureha Chemical Industry, Tokyo, Japan
    Br J Cancer 72:708-14. 1995
    ..of chemokines on tumour growth, the genes for human (hu) interleukin 8 (IL-8), hu-MCP-1 (MCAF), hu-MIP-1 alpha (LD78), murine (mu)-MCP-1 (JE), mu-MIP-1 alpha or mu-MIP-2 were introduced, via mammalian expression vectors, into ..
  39. doi Efficiency of test report delivery to the requesting physician in an outpatient setting: an observational study
    Ana Maria Simundic
    University Department of Chemistry, University Hospital Sestre Milosrdnice, Zagreb, Croatia
    Clin Chem Lab Med 47:1063-6. 2009
    ..Failure to report results may indicate the ineffectiveness of the laboratory service. We aimed to analyze the proportion and type of laboratory reports for outpatients that were not delivered to the requesting physician...
  40. ncbi The third human homolog of a murine gene encoding an inhibitor of stem cell proliferation is truncated and linked to a CpG island-containing upstream sequence
    L Russell
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    DNA Cell Biol 12:157-75. 1993
    ..We suggest that the CUS-G0S19-3 sequence was generated by recombination between a G0S19-2 gene and a member of a novel CUS-associated gene family...
  41. ncbi The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2
    E Van Coillie
    Rega Institute for Medical Research, Laboratory of Molecular Immunology, University of Leuven, Belgium
    Genomics 40:323-31. 1997
    ..With the use of degenerate primers that were based on CC chemokine consensus sequences, the known MIP-1 alpha/LD78 alpha, MCP-1, and MCP-3 genes and the previously unidentified eotaxin and MCP-2 genes were isolated from a YAC ..
  42. ncbi Effect on high-density lipoprotein cholesterol of maximum dose simvastatin and atorvastatin in patients with hypercholesterolemia: results of the Comparative HDL Efficacy and Safety Study (CHESS)
    Christie M Ballantyne
    Baylor College of Medicine, Houston, Tex 77030, USA
    Am Heart J 146:862-9. 2003
    ..Previous studies have shown that effects on high-density lipoprotein cholesterol (HDL-C) may differ among statins...
  43. ncbi Biopterin in the acute phase of hypoxia-ischemia in a neonatal pig model
    Hiroki Fujioka
    Department of Pediatrics, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi Abeno ku, Osaka 545 8585, Japan
    Brain Dev 30:1-6. 2008
    ..Brain biopterin did not increase in hypoxia-ischemia although plasma biopterin was five-fold elevated. The discrepancy may also affect hypoxic-ischemic organ damage...
  44. doi Gamma-ray induced degradation of diazinon and atrazine in natural groundwaters
    K A Mohamed
    Radiation Technology Center, Atomic Energy Research Institute, King Abdulaziz City for Science and Technology, P O Box 6086, Riyadh 11442, Saudi Arabia
    J Hazard Mater 166:810-4. 2009
    ..Moreover, the presence of naturally occurring inorganic scavengers in solutions of diazinon and atrazine decreased significantly the efficiency of radiolytic degradation of pesticides, especially at higher concentrations...
  45. pmc Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands
    Thomas J Ketas
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Virology 364:281-90. 2007
    ..We conclude that differences in CCR5 expression on human PBMCs, which can be affected by CCL3L1 gene dose, may influence the antiviral potency of CCR5 ligands in vitro, but other host factors are also likely to ..
  46. doi Cultivation of microalgae for oil production with a cultivation strategy of urea limitation
    Chih Hung Hsieh
    Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan
    Bioresour Technol 100:3921-6. 2009
    ..The maximum lipid productivity of 0.139 g d(-1)L(-1) in the semi-continuous culture was highest in comparison with those in the batch and fed-batch cultivations...
  47. ncbi Phototoxicity of azaarene isomers to the marine flagellate Dunaliella tertiolecta
    S Wiegman
    Department of Aquatic Ecology and Ecotoxicology, ARISE, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Environ Toxicol Chem 20:1544-50. 2001
    ....
  48. pmc Circumstances of out of hospital cardiac arrest in patients with ischaemic heart disease
    R M Norris
    Heart 91:1537-40. 2005
    ..To discover the circumstances of out of hospital cardiac death irrespective of resuscitation attempts...
  49. pmc Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta
    L J Sandell
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, United States
    Osteoarthritis Cartilage 16:1560-71. 2008
    ..To provide a more complete picture of the effect of interleukin-1 beta (IL-1beta) on adult human articular chondrocyte gene expression, in contrast to the candidate gene approach...
  50. doi The impact of CCL3L1 copy number in an HIV-1-infected white population
    Erika Y Lee
    Department of Immunology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    AIDS 24:1589-91. 2010
    We examined the effect of CCL3L1 gene copy number on disease progression in a North American white cohort of HIV-1-infected individuals...
  51. ncbi Platelet-derived growth factor-inducible gene JE is a member of a family of small inducible genes related to platelet factor 4
    R S Kawahara
    Department of Medicine, Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110
    J Biol Chem 264:679-82. 1989
    ..secretory protein which shows striking similarity to the gene products of a family of small inducible genes (SIG), LD78, TCA3, IP10, 3-10C, 9E3/pCEF4, and gro/MGSA, and to several of the proteins secreted from platelet alpha-granules...
  52. ncbi Susceptibility to HIV/AIDS: an individual characteristic we can measure?
    B Julg
    Dept of Infectious Diseases, Medical Policlinic, Ludwig Maximilian University Munich, Pettenkoferstr 8a, 80336 Munich, Germany
    Infection 33:160-2. 2005
    ..and interpopulation difference in the copy number of a segmental duplication encompassing the gene encoding CCL3L1, a potent human immunodeficiency virus-1 (HIV- 1)-suppressive chemokine was found...
  53. pmc Determination of beta-defensin genomic copy number in different populations: a comparison of three methods
    Peder Fode
    Department for Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 6:e16768. 2011
    There have been conflicting reports in the literature on association of gene copy number with disease, including CCL3L1 and HIV susceptibility, and β-defensins and Crohn's disease...
  54. ncbi Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)
    Y Furutani
    Research Laboratories, Dainippon Pharmaceutical Co Ltd, Suita Osaka, Japan
    Biochem Biophys Res Commun 159:249-55. 1989
    ..cytokine family, including macrophage inflammatory protein and some putative polypeptide mediators known as JE, LD78, RANTES and TCA-3...
  55. ncbi Chemokine-protease interactions in cancer
    Jo Van Damme
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Semin Cancer Biol 14:201-8. 2004
    ..Migration of Th1/CCR5+ and Th2/CCR4+ effector lymphocytes toward CCR5 (CCL5, CCL3L1) and CCR4 (CCL22) ligands is affected by cleavage...
  56. doi Genetic determinants of HIV-1 infection and progression to AIDS: susceptibility to HIV infection
    G Kaur
    Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India
    Tissue Antigens 73:289-301. 2009
    ..with increased likelihood of infection and development of AIDS, and (iii) the Indian population generally has low CCL3L1 copy numbers (approximately 2.3)...
  57. doi Human gene copy number variation and infectious disease
    Edward J Hollox
    Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Hum Genet 133:1217-33. 2014
    ..to severe malaria, as well as more recent controversies, such as the extensive CNV of the chemokine gene CCL3L1 and HIV infection...
  58. pmc Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers
    Wendy E Walker
    Center of Excellence in Infectious Diseases, Department of Biomedical Sciences, TTUHSC El Paso, El Paso, Texas, USA Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Virol 89:5502-14. 2015
    ..Notably, the genes encoding macrophage inflammatory protein 1α (MIP-1α), CCL3 and CCL3L1, were found to be upregulated...
  59. ncbi Up-regulation of CC chemokine, CCL3L1, and receptors, CCR3, CCR5 in human glioblastoma that promotes cell growth
    Jun Kouno
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kosugi, Kawasaki, Tokyo, Japan
    J Neurooncol 70:301-7. 2004
    Human CC ligand 3-like protein 1 (CCL3L1), a member of the CC chemokine family, that induces MCP1 and RANTES, exhibits a variety of proinflammatory activities including chemotaxis, and functional and proliferative activation of leukocytes,..
  60. ncbi Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial
    Z M Chen
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Richard Doll Building, Old Road Campus, Oxford OX3 7LF, UK
    Lancet 366:1622-32. 2005
    ....
  61. ncbi Diverse signalling by different chemokines through the chemokine receptor CCR5
    Anja Mueller
    School of Animal and Microbial Sciences, University of Reading, PO Box 228, Reading, RG6 6AJ, UK
    Biochem Pharmacol 72:739-48. 2006
    ..Four isoforms of the chemokine CCL3 with different amino termini (CCL3, CCL3(2-70), CCL3(5-70), CCL3L1) were tested in these assays in order to probe structure/activity relationships. Each isoform exhibited agonism...
  62. ncbi Postgenomic up-regulation of CCL3L1 expression in HTLV-2-infected persons curtails HIV-1 replication
    Elisabetta Pilotti
    Department of Clinical Medicine, Nephrology, and Health Sciences, University of Parma, Italy
    Blood 109:1850-6. 2007
    ..Two nonallelic genes code for CCL3 and CCL3L1 isoforms of MIP-1alpha, and the population-specific copy number of CCL3L1 exerts a profound effect on HIV-1 ..
  63. ncbi Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis
    C McKinney
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand
    Ann Rheum Dis 67:409-13. 2008
    ..Chemokine ligand 3-like 1 (CCL3L1) is encoded by a variable copy-number gene, and binds to several pro-inflammatory cytokine receptors, including ..
  64. ncbi HIV-1 pathogenesis: the complexities of the CCR5-CCL3L1 complex
    John P Moore
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, NY 10065 4896, USA
    Cell Host Microbe 2:281-3. 2007
    ..Its chemokine ligands, including CCL3L1, efficiently inhibit infection by receptor blockade and downmodulation. However, in Nature Immunology, Dolan et al...
  65. ncbi [Impact of electrical shock waveform and paddle positions on efficacy of direct current cardioversion for atrial fibrillation]
    Giedre Stanaitiene
    Department of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania
    Medicina (Kaunas) 44:665-72. 2008
    ....
  66. doi HIV-1/AIDS susceptibility and copy number variation in CCL3L1, a gene encoding a natural ligand for HIV-1 co-receptor CCR5
    T Nakajima
    Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Cytogenet Genome Res 123:156-60. 2008
    ..Human CC chemokine ligand 3-like 1 gene (CCL3L1), which is located on human chromosome 17q11...
  67. doi Copy number variation of CCL3L1 influences asthma risk by modulating IL-10 expression
    Haeyong Lee
    Department of Microbiology, Chung Ang University College of Medicine, Seoul, 156 756, Republic of Korea
    Clin Chim Acta 412:2100-4. 2011
    Copy number of Chemokine ligand 3-like 1 (CCL3L1) is associated with various immune disorders. This study was conducted to assess the role of CCL3L1 in asthma by both association analyses of human subjects and in vitro functional analyses.
  68. doi Association analysis of the CCL3L1 copy number locus by paralogue ratio test in Norwegian rheumatoid arthritis patients and healthy controls
    G B N Nordang
    Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway
    Genes Immun 13:579-82. 2012
    ..This is reflected by inconsistent results published for the CNV C-C chemokine ligand 3-like 1 (CCL3L1) and its contribution to rheumatoid arthritis (RA) susceptibility...
  69. ncbi Difference in clinical and angiographic characteristics of very late stent thrombosis between drug-eluting and bare-metal stent implantations
    Shunsuke Kubo
    Department of Cardiology, Kurashiki Central Hospital, Kurashiki 710 8602, Japan
    Circ J 77:1453-60. 2013
    ..The purpose of this study was to investigate the differences in the characteristics of VLST after DES and BMS implantation by reviewing the clinical and angiographic data...
  70. pmc Transcriptional and posttranscriptional regulation of cytokine gene expression in HIV-1 antigen-specific CD8+ T cells that mediate virus inhibition
    Tamika L Payne
    Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA
    J Virol 88:9514-28. 2014
    ..in the abundance of mRNAs encoding the antiviral cytokines macrophage inflammatory proteins MIP-1α, MIP-1αP (CCL3L1), and MIP-1β; granulocyte-macrophage colony-stimulating factor (GM-CSF); lymphotactin (XCL1); tumor necrosis ..
  71. doi Identification of sequence variants in the CCL3 chemokine gene family in the HapMap West African reference population
    Rodney T Perry
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Hum Immunol 75:854-8. 2014
    Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases...
  72. ncbi Determination of S-methyl-, S-propyl-, and S-propenyl-L-cysteine sulfoxides by gas chromatography-mass spectrometry after tert-butyldimethylsilylation
    Kouichiro Tsuge
    National Research Institute of Police Science, 6 3 1 Kashiwanoha, Kashiwa, Chiba 277 0882, Japan
    J Agric Food Chem 50:4445-51. 2002
    ..The contents of 1, 2, and 3 in commercial onion were estimated to be 0.3, 3.1, and 3.0 mg, respectively, per gram of fresh weight...
  73. ncbi [Role of chemokines in the HIV infection process]
    P Proost
    Rega Instituut, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Verh K Acad Geneeskd Belg 64:403-20. 2002
    ..The MIP-1 alpha-isoform LD78 beta, that was purified form natural sources, inhibited HIV-infection completely in CCR5-transfected cells, ..
  74. ncbi Genetic basis of HIV-1 resistance and susceptibility: an approach to understand correlation between human genes and HIV-1 infection
    Vijay Kumar
    Department of Microbiology, Panjab University, Chandigarh, India
    Indian J Exp Biol 44:683-92. 2006
    ..On the other hand, non MHC encoded genes are CCR5, CCR2, RANTES, CXCL12, CXCR6, CCL3L1, Interleukin-10 (IL-10), and interferon gamma...
  75. pmc Variation in CCL3L1 copy number in rhesus macaques (Macaca mulatta)
    Patrick L Taormina
    Forensic Science Graduate Program, University of California, Davis, California, USA
    Comp Med 62:218-24. 2012
    We used real-time quantitative PCR (qPCR) methodology to examine copy number variation (CNV) of the CCL3L1 gene among pure Indian-origin, pure Chinese-origin, and hybrid Indian-Chinese rhesus macaques (Macaca mulatta)...
  76. pmc Increase in chemokines CXCL10 and CCL2 in blood from pigs infected with high compared to low virulence African swine fever virus isolates
    Emma Fishbourne
    The Pirbright Institute, Pirbright, Woking, Surrey GU24 0NF, UK
    Vet Res 44:87. 2013
    ..Levels of mRNAs for CCL2, CCL3L1, CCL4, CXCL10, CCR1 and CCR5 were significantly increased in at least one time point following infection in two ..
  77. pmc Structures of human genes coding for cytokine LD78 and their expression
    M Nakao
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Mol Cell Biol 10:3646-58. 1990
    b>LD78 is a member of a newly identified superfamily of small inducible proteins involved in inflammatory responses, wound healing, and tumorigenesis...
  78. ncbi Genomic structure of murine macrophage inflammatory protein-1 alpha and conservation of potential regulatory sequences with a human homolog, LD78
    U Widmer
    Laboratory of Medical Biochemistry, Rockefeller University, New York, NY 10021
    J Immunol 146:4031-40. 1991
    ..site are highly homologous to corresponding regions of the human gene encoding a CC peptide variously designated as LD78/GOS19/pAT464, including consensus regulatory motifs in common, reinforcing the contention that MIP-1 alpha and LD78 ..
  79. ncbi Three human homologs of a murine gene encoding an inhibitor of stem cell proliferation
    S Blum
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    DNA Cell Biol 9:589-602. 1990
    ..As such, it is a potential antioncogene...
  80. ncbi Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors
    H Nomura
    Department of Pharmacology, Cancer Research Institute, Kanazawa University, Japan
    Int Immunol 5:1239-49. 1993
    ..Furthermore, it was confirmed that HM145 is a functional receptor for LD78, one of the C-C chemokines, as revealed by the measurement of decrease of cAMP accumulation as well as calcium ..
  81. ncbi Identification of MIP-1 alpha/LD78 as a monocyte chemoattractant released by the HTLV-I-transformed cell line MT4
    R Bertini
    Laboratories of Biotechnology, Research Center Dompé S p A, L Aquila, Italy
    AIDS Res Hum Retroviruses 11:155-60. 1995
    ..of 25 amino acids revealed identity with the C-C chemokine macrophage inflammatory protein-1 alpha (MIP-1 alpha/LD78). An anti-MIP-1 alpha/LD78 rabbit antiserum substantially inhibited chemotaxis of the MT4 chemoattractant...
  82. ncbi Expression and distribution of CC chemokine macrophage inflammatory protein-1 alpha/LD78 in the human brain
    K Ishizuka
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Japan
    Neuroreport 8:1215-8. 1997
    Macrophage inflammatory protein (MIP)-1 alpha, also known as LD78, is a member of a family of chemokines which recruit leukocytes to sites of inflammation...
  83. ncbi Chemokine PARC gene (SCYA18) generated by fusion of two MIP-1alpha/LD78alpha-like genes
    Y Tasaki
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan
    Genomics 55:353-7. 1999
    ..Since there are variably duplicated copies of the MIP-1alpha gene called LD78beta (HGMW-approved symbol SCYA3L) in the vicinity of the MIP-1alpha gene, the locus surrounding the MIP-1alpha gene ..
  84. pmc The LD78beta isoform of MIP-1alpha is the most potent CC-chemokine in inhibiting CCR5-dependent human immunodeficiency virus type 1 replication in human macrophages
    S Aquaro
    Laboratory of Experimental Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium
    J Virol 75:4402-6. 2001
    ..MIP-1alpha, also known as LD78alpha, has an isoform, LD78beta, which was identified as the product of a nonallelic gene. The two isoforms differ in only 3 amino acids...
  85. ncbi Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family
    A M Lambeir
    Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1 S6, B 2610 Antwerp, Belgium
    J Biol Chem 276:29839-45. 2001
    ..The data not only provide insight into the selectivity of the enzyme for specific chemokines, but they also contribute to the general understanding of CD26/dipeptidyl peptidase IV secondary substrate specificity...
  86. ncbi Identification of amino acid residues critical for LD78beta, a variant of human macrophage inflammatory protein-1alpha, binding to CCR5 and inhibition of R5 human immunodeficiency virus type 1 replication
    Toshikazu Miyakawa
    Department of Internal Medicine II, Kumamoto University School of Medicine, Honjo 1 1 1, Kumamoto 860 0811, Japan
    J Biol Chem 277:4649-55. 2002
    In an attempt to determine which amino acid(s) of LD78beta, a variant of human macrophage inflammatory protein-1alpha, plays a critical role in the interaction with CCR5, we generated six LD78beta variants with an amino acid substituted ..
  87. ncbi Macrophage inflammatory protein-1
    Patricia Menten
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B 3000, Leuven Belgium
    Cytokine Growth Factor Rev 13:455-81. 2002
    ..Since both human MIP-1alpha subtypes (LD78alpha and LD78beta) and MIP-1beta signal through CCR5, the major co-receptor for M-tropic HIV-1 strains, these chemokines are ..
  88. ncbi Cytokine transcript profiling in CD34+-progenitor derived dendritic cells exposed to contact allergens and irritants
    Geert R Verheyen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO, Boeretang 200, B 2400 Mol, Belgium
    Toxicol Lett 155:187-94. 2005
    We here investigated wether genes encoding the interleukins IL-1beta, IL-6 and IL-8, and the chemokines CCL2, CCL3, CCL3L1 and CCL4 are useful markers for sensitization testing in CD34+-progenitor derived dendritic cells (CD34-DC)...
  89. ncbi Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients
    Roger Colobran
    Laboratory of Immunobiology for Research and Application to Diagnosis, Centre for Transfusion and Tissue Bank, Institut d Investigació en Ciències de la Salut Germans Trias i Pujol, Barcelona, Spain
    J Immunol 174:5655-64. 2005
    ..the SCYA4 and SCYA3 genes which, in turn, present a variable number of additional non-allelic copies (SCYA4L and SCYA3L1)...
  90. ncbi CCL3L1 dose and HIV-1 susceptibility
    Charles R Mackay
    Arthritis and Inflammation Research Program, The Garvan Institute of Medical Research, 384 Victoria Street, Sydney, NSW 2010, Australia
    Trends Mol Med 11:203-6. 2005
    ..genetic determinant for HIV-1 susceptibility and disease progression: copy number of a chemokine gene termed CCL3L1. Individuals with low copy numbers of the gene, relative to their ethnic background, were associated with markedly ..
  91. ncbi Genetics of resistance to HIV infection: Role of co-receptors and co-receptor ligands
    Fernando Arenzana-Seisdedos
    Unité de Pathogénie Virale Moléculaire, Departement de Virologie, INSERM, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex, France
    Semin Immunol 18:387-403. 2006
    ..Specific haplotypes encompassing the CCR5 and CCR2 loci, and the copy number of the CCL3L1 gene, have also been convincingly correlated with delayed progression...
  92. ncbi Nucleotide metabolizing ecto-enzymes in Walker 256 tumor cells: molecular identification, kinetic characterization and biochemical properties
    Andreia Buffon
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Life Sci 80:950-8. 2007
    ..The presence of NTPDases and 5'-nucleotidase enzymes in Walker 256 tumor cells may be important to regulate the ratio adenine nucleotides/adenine nucleoside extracellularly, therefore motivating tumor growth...
  93. ncbi [Evaluation of individual vulnerability to HIV infection of health care employees--hope or reality?]
    Piotr Białecki
    Katedra i Klinika Ortopedii i Traumatologii, Pomorskiej Akademii Medycznej w Szczecinie
    Przegl Lek 63:797-9. 2006
    ..Similary, the level of cytokine depends on the number of gene CCL3L1 copy and it influences susceptibility to HIV-1 infection and AIDS development.
  94. ncbi Effect of temperature on plasma freezing under industrial conditions
    M I Bravo
    Instituto Grifols, Barcelona, Spain
    Pharmeur Sci Notes 2006:31-5. 2006
    ....
  95. pmc A Bayesian approach to copy-number-polymorphism analysis in nuclear pedigrees
    Konstantina Kosta
    School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Am J Hum Genet 81:808-12. 2007
    ..We have implemented the basic model for use with nuclear families, and we illustrate its application through an analysis of the CNP located in gene CCL3L1 in 201 families with asthma.
  96. ncbi Molecular and cellular interactions of HIV-1/HTLV coinfection and impact on AIDS progression
    Claudio Casoli
    Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Italy
    AIDS Rev 9:140-9. 2007
    ..Investigations of the natural factors induced by HTLV-2 that influence HIV-1 replication show that CCL3L1 (an isoform of CCL3) is preferentially induced in HTLV-2 exposed seronegative HIV individuals and in long-term ..
  97. pmc Ethnic differences in adolescent lung function: anthropometric, socioeconomic, and psychosocial factors
    Melissa J Whitrow
    Medical Research Council, Social and Public Health Sciences Unit, 4 Lilybank Gardens, Glasgow G12 8RZ, UK
    Am J Respir Crit Care Med 177:1262-7. 2008
    ..The relative contribution of body proportion and social exposures to ethnic differences in lung function has not previously been reported in the United Kingdom...
  98. pmc CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals
    Sunil K Ahuja
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, 7400 Merton Minter, San Antonio, Texas 78229, USA
    Nat Med 14:413-20. 2008
    ..Here, we show that variations in CCL3L1 gene dose and CCR5 genotype, but not major histocompatibility complex HLA alleles, influence immune reconstitution,..
  99. pmc Independent effects of genetic variations in mannose-binding lectin influence the course of HIV disease: the advantage of heterozygosity for coding mutations
    Gabriel Catano
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, USA
    J Infect Dis 198:72-80. 2008
    ..The in vivo impact of mannose-binding lectin (MBL), a molecule involved in innate immunity, on the pathogenesis of human immunodeficiency virus (HIV)-1 infection and AIDS is unknown...

Research Grants16

  1. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    Jianming Tang; Fiscal Year: 2012
    ..covers genes in the pathway for expression of the HIV-1 chemokine co-receptor and its ligands (CCR2, CCR5, CCL3, CCL3L1, CCL4, CCL4L1, and CCL5). Related new candidate genes will be considered...
  2. Basic and Comparative Studies of CCR5 Inhibition to Prevent HIV Transmission
    MICHAEL MARCEL LEDERMAN; Fiscal Year: 2010
    ..We will also examine the impact of CCR5, CCL5, and CCL3L1 genetic polymorphisms on CCR5 protein synthesis and turnover rate...
  3. Measurement of CCR5 and CCL3L1 on Single Cell by Fluorescent Metal Nanoparticle
    Richard Yuqi Zhao; Fiscal Year: 2010
    ..However, the interaction of CCR5 by its ligand CCL3L1 provides strong counteraction against HIV-1 infection...
  4. CHRYSTALLIZING DISULFIDE-STABILIZED HIV-1 ENV PROTEINS
    John Moore; Fiscal Year: 2004
    ..Any information accruing from the structure of a native Env trimer could facilitate the rational design of Env-based vaccines. ..
  5. Pediatric ACTG Coordinating and Operations Center
    Stephen Spector; Fiscal Year: 2005
    ..abstract_text> ..
  6. Genetic Epidemiology of HAD Susceptibility Genes
    Sunil Ahuja; Fiscal Year: 2009
    ..110. We have submitted a request for addition of a new subtitle: "Genetic epidemiology of HIV-associated dementia". ..
  7. HIV NEUTRALIZATION IN VITRO & IN SHIV-INFECTED MACAQUES
    John Moore; Fiscal Year: 2001
    ....
  8. MAC 1/LFA 1/P150 95 AND PMN LEUKOCYTE FUNCTION
    Christie Ballantyne; Fiscal Year: 2002
    ..3. Characterize the contribution of each CD11 integrin on the host response to common bacterial and fungal pathogens in vitro and in vivo. ..
  9. Role of DC-SIGN in HIV infection
    Sunil Ahuja; Fiscal Year: 2003
    ..Our studies also place us in a unique position to pursue strategies to block DC-HIV interactions thought to be necessary for HIV transmission. ..
  10. ENTRY INHIBITORS AS TOPICAL MICROBICIDES AGAINST HIV-1
    John Moore; Fiscal Year: 2004
    ..Moore, Ph.D., Fusion-Inhibitor Acquisition, Evaluation and Formulation; Administrative Core: John P. Moore, Ph.D. ..
  11. FACTORS IN PEDIATRIC AIDS TRANSMISSION AND PATHOGENESIS
    Stephen Spector; Fiscal Year: 2005
    ..The findings of this research will provide an improved understanding of the pathogenesis of HIV-1 infection of children and perinatal transmission, and help to develop improved treatment/prevention strategies. ..
  12. ADOLESCENT MEDICINE TRIALS UNIT (AMTU)
    Stephen Spector; Fiscal Year: 2005
    ..The experience of our team in HIV care, clinical trials and laboratory studies, we believe, will enable our group to make a significant contribution to the success of the ATN. ..
  13. PEDIATRIC AIDS CLINICAL TRIALS GROUP
    Stephen Spector; Fiscal Year: 2006
    ..abstract_text> ..
  14. Modified Envelope Glycoproteins for HIV-1 Vaccine
    John P Moore; Fiscal Year: 2010
    ..11/07) Page 2 Form Page 2 ..
  15. Obesity, Inflammation and Thrombosis: LOOK AHEAD
    Christie M Ballantyne; Fiscal Year: 2010
    ....