CCL3

Summary

Gene Symbol: CCL3
Description: C-C motif chemokine ligand 3
Alias: G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine 3, G0/G1 switch regulatory protein 19-1, PAT 464.1, SIS-beta, chemokine (C-C motif) ligand 3, macrophage inflammatory protein 1-alpha, small inducible cytokine A3 (homologous to mouse Mip-1a), tonsillar lymphocyte LD78 alpha protein
Species: human

Top Publications

  1. pmc A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function
    S Vallet
    Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Leukemia 25:1174-81. 2011
  2. doi HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages
    Takashi Chihara
    Center for AIDS Research, Kumamoto University, Kumamoto 860 0811, Japan
    J Immunol 188:3620-7. 2012
  3. pmc Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65
    Giuseppe Fiume
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, Viale Europa Germaneto, 88100 Catanzaro, Italy
    Nucleic Acids Res 40:3548-62. 2012
  4. pmc Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines
    A Trkola
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10021, USA
    J Virol 72:396-404. 1998
  5. ncbi Effects of bacterial cell wall components (PAMPs) on the expression of monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha) and the chemokine receptor CCR2 by purified human blood monocytes
    Anne Sophie W Møller
    Department of Clinical Chemistry, The Research and Development Group, Ullevaal University Hospital, N 0450 Oslo, Norway
    J Endotoxin Res 9:349-60. 2003
  6. doi HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection
    Emanuele Fanales-Belasio
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 182:2888-97. 2009
  7. pmc Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer
    Marlene Wolf
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Am J Pathol 162:1183-90. 2003
  8. pmc Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas
    Peirong Lu
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Am J Pathol 162:1249-58. 2003
  9. ncbi CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
    L Wu
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    Nature 384:179-83. 1996
  10. ncbi Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line
    M Matsumoto
    Department of Biochemistry, Hyogo College of Medicine, Japan
    Int Immunol 10:1825-35. 1998

Research Grants

  1. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010
  2. Selective Delivery of a novel bacterial adjuvant for multipurpose vaccination
    GREGOIRE STEPHANE LAUVAU; Fiscal Year: 2013
  3. STRUCTURE AND FUNCTION OF I-309 AND OTHER CHEMOKINES
    MICHAEL KRANGEL; Fiscal Year: 2000
  4. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
  5. Priya Pal; Fiscal Year: 2015
  6. In Vivo Brain Dialysis of Neuropeptides and Neuroimmune Signaling Proteins
    Julie A Stenken; Fiscal Year: 2012
  7. Sulie L Chang; Fiscal Year: 2014
  8. Wei Jen Tang; Fiscal Year: 2015
  9. GREGOIRE STEPHANE LAUVAU; Fiscal Year: 2016
  10. ALEX YEE CHEN HUANG; Fiscal Year: 2015

Detail Information

Publications243 found, 100 shown here

  1. pmc A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function
    S Vallet
    Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Leukemia 25:1174-81. 2011
    Upregulation of cytokines and chemokines is a frequent finding in multiple myeloma (MM). CCL3 (also known as MIP-1α) is a pro-inflammatory chemokine, levels of which in the MM microenvironment correlate with osteolytic lesions and tumor ..
  2. doi HIV-1 proteins preferentially activate anti-inflammatory M2-type macrophages
    Takashi Chihara
    Center for AIDS Research, Kumamoto University, Kumamoto 860 0811, Japan
    J Immunol 188:3620-7. 2012
    ....
  3. pmc Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65
    Giuseppe Fiume
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, Viale Europa Germaneto, 88100 Catanzaro, Italy
    Nucleic Acids Res 40:3548-62. 2012
    ..Our results support a novel mechanism of NF-κB activation via physical interaction of Tat with IκB-α and p65, and may contribute to further insights into the deregulation of the inflammatory response by HIV-1...
  4. pmc Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines
    A Trkola
    The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10021, USA
    J Virol 72:396-404. 1998
    ..Thus, for CCR5, the rank order for down-regulation was also RANTES, MIP-1beta, MIP-1alpha...
  5. ncbi Effects of bacterial cell wall components (PAMPs) on the expression of monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha) and the chemokine receptor CCR2 by purified human blood monocytes
    Anne Sophie W Møller
    Department of Clinical Chemistry, The Research and Development Group, Ullevaal University Hospital, N 0450 Oslo, Norway
    J Endotoxin Res 9:349-60. 2003
    ....
  6. doi HIV-1 Tat addresses dendritic cells to induce a predominant Th1-type adaptive immune response that appears prevalent in the asymptomatic stage of infection
    Emanuele Fanales-Belasio
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 182:2888-97. 2009
    ....
  7. pmc Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer
    Marlene Wolf
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Am J Pathol 162:1183-90. 2003
    ..breast carcinoma cell lines MCF-7 and T47D, selectively degrade macrophage inflammatory protein (MIP)-1 alpha (CCL3), MIP-1 beta (CCL4), and SLC (CCL21)...
  8. pmc Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas
    Peirong Lu
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Am J Pathol 162:1249-58. 2003
    ..Furthermore, CCL3 expression was detected in hepatoma cells, endothelial cells, and to a lesser degree, fibroblast-like cells in ..
  9. ncbi CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
    L Wu
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    Nature 384:179-83. 1996
    ..These results suggest that HIV-1 attachment to CD4 creates a high-affinity binding site for CCR-5, leading to membrane fusion and virus entry...
  10. ncbi Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line
    M Matsumoto
    Department of Biochemistry, Hyogo College of Medicine, Japan
    Int Immunol 10:1825-35. 1998
    ..These findings indicate that MIP-1 alpha is a direct target of NF-IL6...
  11. doi CC chemokine ligand 3 and receptors 1 and 5 gene expression in recurrent aphthous stomatitis
    Camila B Gallo
    Stomatology Department, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol 114:93-8. 2012
    The aim of this study was to investigate the local and systemic expression of CC-chemokine ligand 3 (CCL3) and its receptors (CCR1 and CCR5) in tissue samples and peripheral blood mononuclear cells of recurrent aphthous stomatitis (RAS) ..
  12. pmc Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta
    B Sherry
    Laboratory of Medical Biochemistry, Rockefeller University, New York, New York 10021
    J Exp Med 168:2251-9. 1988
    ..9% sequence identity) products of different genes...
  13. ncbi Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines
    V Sharma
    Division of Hematology and Oncology, Arthur G James Cancer Hospital and Research Institute, Ohio State University, Columbus 43210
    Biochem Biophys Res Commun 208:704-13. 1995
    ....
  14. ncbi Specificity and reciprocity in the interactions between TGF-beta and macrophage inflammatory protein-1 alpha
    J Maltman
    Beatson Institute for Cancer Research, Cancer Research Campaign Beatson Laboratories, Bearsden, Glasgow, U K
    J Immunol 156:1566-71. 1996
    ..However, such interplay may also be dependent on the local cytokine or inflammatory profile to which the cells are exposed...
  15. ncbi Increased interleukin-10 and macrophage inflammatory protein-1 alpha release from blood monocytes ex vivo during late-phase response to allergen in asthma
    S Lim
    National Heart and Lung Institute, Imperial College School of Medicine, and Royal Brompton Hospital, London, UK
    Allergy 55:489-95. 2000
    ..We determined the effect of late-phase responses to allergen challenge of mildly allergic asthmatic patients on the expression and release of the cytokines IL-10 and MIP-1alpha from peripheral blood monocytes...
  16. ncbi Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity
    Ennan Guan
    Division of Therapeutic Proteins, CBER, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 277:32348-52. 2002
    ..synthesize and secrete substantial amounts of the beta-chemokines macrophage inflammatory protein (MIP)-1 alpha/CCL3 and MIP-1 beta/CCL4, both of which inhibit infection of cells with human immunodeficiency virus type 1 (HIV-1)...
  17. ncbi The presence of chemokine (MCP-1, MIP-1alpha, MIP-1beta, IP-10, RANTES)-positive cells and chemokine receptor (CCR5, CXCR3)-positive cells in inflamed human gingival tissues
    Hiroaki Kabashima
    Section of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    Cytokine 20:70-7. 2002
    ..In contrast, no factor expression was observed in periodontally healthy gingival tissue. Our findings suggest that these chemokines may be responsible for modulating the process of infectious disease such as marginal periodontitis...
  18. doi Cysteinyl leukotrienes induce macrophage inflammatory protein-1 in human monocytes/macrophages
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
    Int Arch Allergy Immunol 148:147-53. 2009
    ..Macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta are known for their chemotactic and proinflammatory effects on monocytes/macrophages which have a cysteinyl leukotriene 1 (CysLT(1)) receptor...
  19. pmc CCAAT/enhancer-binding protein β and NF-κB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1β
    Zhiqi Zhang
    Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    J Biol Chem 285:33092-103. 2010
    ..the mechanism of transcriptional regulation, deletion constructs of selected chemokine gene promoters, the human CCL3 (MIP-1α) and CCL4 (MIP-1β), were transfected into human chondrocytes with or without IL-1β...
  20. pmc Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme
    Min Ren
    Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    EMBO J 29:3952-66. 2010
    Macrophage inflammatory protein-1 (MIP-1), MIP-1α (CCL3) and MIP-1β (CCL4) are chemokines crucial for immune responses towards infection and inflammation. Both MIP-1α and MIP-1β form high-molecular-weight aggregates...
  21. pmc CCL3 (MIP-1α) plasma levels and the risk for disease progression in chronic lymphocytic leukemia
    Mariela Sivina
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Blood 117:1662-9. 2011
    ..In response to BCR activation, CLL cells secrete the chemokine CCL3, which fosters interactions between CLL cells and the leukemia microenvironment...
  22. pmc Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1
    Jianru Wang
    Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Arthritis Rheum 65:832-42. 2013
    To investigate tumor necrosis factor α (TNFα) and interleukin-1β (IL-1β) regulation of CCL3 expression in nucleus pulposus (NP) cells and in macrophage migration.
  23. ncbi HIV-1 Vpr and anti-inflammatory activity
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 23:239-47. 2004
    ..These activities are worthy of further examination for control of hyperinflammatory and hyperproliferative conditions...
  24. ncbi HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: involvement of Nef endocytotic signals and NF-kappa B activation
    Eleonora Olivetta
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Immunol 170:1716-27. 2003
    ..Our data add new hints supporting the idea that the presence of Nef is per se heavily detrimental for monocyte/macrophages and relative cross-talking cell types...
  25. ncbi Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES
    C Combadiere
    The Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 60:147-52. 1996
    ..These data suggest that CC CKR5 is a G(i)-coupled receptor that may mediate monocyte responses to MIP-1alpha, MIP-1beta, and RANTES...
  26. ncbi The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    F Cocchi
    Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
    Nat Med 2:1244-7. 1996
    ..The ability of the chemokines to block the early steps of HIV infection could be exploited to develop novel therapeutic approaches for AIDS...
  27. ncbi In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression
    G Scarlatti
    Unit of Immunobiology of HIV, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Nat Med 3:1259-65. 1997
    ..These results suggest an adaptive evolution of HIV-1 in vivo, leading to escape from the control of the antiviral C-C chemokines...
  28. pmc Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway
    W Popik
    Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Virol 72:6406-13. 1998
    ....
  29. ncbi Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
    M Farzan
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:667-76. 1999
    ..CXCR4, another important HIV-1 coreceptor, is also sulfated. Tyrosine sulfation may contribute to the natural function of many 7TMS receptors and may be a modification common to primate immunodeficiency virus coreceptors...
  30. ncbi HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
    S Swingler
    University of Massachusetts Medical Center, Program in Molecular Medicine, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Med 5:997-103. 1999
    ..These results indicate a role for Nef in lymphocyte recruitment and activation at sites of virus replication...
  31. pmc Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alpha
    Y Maeda
    Department of Biodefence and Medical Virology, School of Medicine, Kumamoto University, Kumamoto, Japan
    J Virol 74:1787-93. 2000
    ..These results indicated that V2 combined with the V3 region of the CCR5-tropic HIV-1 envelope modulates the sensitivity of HIV-1 to C-C chemokines without altering the ability to use chemokine receptors...
  32. ncbi Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses
    Emanuele Fanales-Belasio
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Immunol 168:197-206. 2002
    ..Thus, Tat can act as both Ag and adjuvant, capable of driving T cell-mediated immune responses...
  33. ncbi MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture
    Lei Wang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Hematology 7:113-7. 2002
    ..05). These data indicate that hMSCs are targeted by inflammatory chemotactic agents and cytokines and that ischemic brain attracts hMSCs...
  34. ncbi Human immunodeficiency virus type 1 (HIV-1) Nef activates STAT3 in primary human monocyte/macrophages through the release of soluble factors: involvement of Nef domains interacting with the cell endocytotic machinery
    Zulema Percario
    Department of Biology, University of Roma Tre, Rome, Italy
    J Leukoc Biol 74:821-32. 2003
    ....
  35. ncbi CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection
    W Shao
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Genes Immun 8:224-31. 2007
    As members of the chemokine family, macrophage inflammatory protein 1 alpha (MIP-1alpha) and MIP-1beta are unique in that they both consist of non-allelic isoforms encoded by different genes, namely chemokine (C-C motif) ligand 3 (CCL3), ..
  36. doi Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways
    Fabrizio Montecucco
    Laboratory of Phagocyte Physiopathology, First Clinic of Internal Medicine, Department of Internal Medicine and Medical Specialties, University of Genoa Medical School, Genoa, Italy
    Cell Signal 20:557-68. 2008
    ..the present study to investigate the effect of short term incubation with TNF-alpha on neutrophil migration to CCL3, a chemokine produced in inflammatory sites and normally devoid of neutrophil chemotactic properties...
  37. pmc HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes
    Cinzia Nobile
    Virus and Immunity Unit, Department of Virology, Institut Pasteur, URA CNRS 3015, 28 rue du Dr Roux, Paris Cedex 15, France
    J Virol 84:2282-93. 2010
    ..of infected cells to fibronectin, their spontaneous motility, and their migration toward chemokines (CXCL12, CCL3, and CCL19) were all significantly decreased...
  38. pmc Structural basis of chemokine sequestration by a tick chemokine binding protein: the crystal structure of the complex between Evasin-1 and CCL3
    Joao M Dias
    Merck Serono Geneva Research Center, Merck Serono S A, Geneva, Switzerland
    PLoS ONE 4:e8514. 2009
    ..Anti-chemokine activity has been described in the extracts of tick salivary glands, and we have recently described the cloning and characterization of such chemokine binding proteins from the salivary glands, which we have named Evasins...
  39. doi MCP-1 and MIP-1α expression in a model resembling early immune response to dengue
    Beatriz Sierra
    Virology Department, PAHO WHO Collaborating Center for the Study of Dengue and its Vector, Institute of Tropical Medicine Pedro Kouri, Autopista Novia del Mediodía Km 6, La Lisa, Havana City, Cuba
    Cytokine 52:175-83. 2010
    ..This study was aimed at evaluating the expression of the CC-chemokines MIP-1α/CCL3 and MCP-1/CCL2 in peripheral blood leukocytes using an ex vivo model resembling dengue infection in vivo, in ..
  40. pmc Secretion of MIP-1β and MIP-1α by CD8(+) T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage
    Kevin O Saunders
    Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Cell Immunol 266:154-64. 2011
    ..We define a multifactorial cytokine profile of CD8(+) T-lymphocytes capable of mediating noncytolytic suppression of CXCR4-tropic HIV-1 replication...
  41. pmc New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection
    Javier Garcia-Perez
    INSERM U819 Unité de Pathogénie Virale, Institut Pasteur, 75724 Paris Cedex 15, France
    J Biol Chem 286:4978-90. 2011
    CC chemokine receptor 5 (CCR5) is a G-protein-coupled receptor for the chemokines CCL3, -4, and -5 and a coreceptor for entry of R5-tropic strains of human immunodeficiency virus type 1 (HIV-1) into CD4(+) T-cells...
  42. ncbi Expression and distribution of CC chemokine macrophage inflammatory protein-1 alpha/LD78 in the human brain
    K Ishizuka
    Department of Neuropsychiatry, Kumamoto University School of Medicine, Japan
    Neuroreport 8:1215-8. 1997
    ..In situ hybridization showed that MIP-1 alpha mRNA was expressed in both neurones as well as glial cells in this patient. These results suggest a heterogeneous distribution of MIP-1 alpha in human brain...
  43. pmc Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domains
    K S Weber
    Institut für Prophylaxe der Kreislaufkrankheiten, Ludwig Maximilians Universitat, D 80336 MUnchen, Germany
    Mol Biol Cell 10:861-73. 1999
    ..Our data suggest that a specific regulation of beta2 integrin avidity by chemokines may be important in leukocyte extravasation and may be triggered by distinct activation pathways transduced via the alpha subunit cytoplasmic domains...
  44. ncbi TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression
    B R Lane
    Department of Internal Medicine, Graduate Program in Cellular and Molecular Biology, School of Public Health, University of Michigan Medical Center, Ann Arbor 48109, USA
    J Immunol 163:3653-61. 1999
    ..These findings suggest that TNF-alpha plays a significant role in inhibiting monocytotropic strains of HIV-1 by two distinct, but complementary, mechanisms...
  45. ncbi HIV-1 Vpr regulates expression of beta chemokines in human primary lymphocytes and macrophages
    K Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
    J Leukoc Biol 68:366-72. 2000
    ..These results suggest that a Vpr-mediated increase in virus replication could be in part through down-regulation of chemokine production...
  46. ncbi The role of macrophage inflammatory protein-1 alpha/CCL3 in regulation of T cell-mediated immunity to Cryptococcus neoformans infection
    M A Olszewski
    Veterans Affairs Hospital and Division of Pulmonary and Critical Care Medicine, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 165:6429-36. 2000
    Macrophage inflammatory protein-1alpha (MIP-1alpha/CCL3) is a CC chemokine required for optimal recruitment of leukocytes in response to cryptococcal Ags...
  47. ncbi HIV-1 viral protein R (Vpr) & host cellular responses
    Richard Yuqi Zhao
    Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 600, Baltimore, MD 21201, USA
    Indian J Med Res 121:270-86. 2005
    ..Strategies with potential application for future antiviral therapies directed at suppressing Vpr activities are described...
  48. ncbi Skin reactivity and local cell recruitment in human atopic and nonatopic subjects by CCL2/MCP-1 and CCL3/MIP-1alpha
    M Gaga
    Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, UK
    Allergy 63:703-11. 2008
    ..protein (MCP-1/CCL2), the ligand for CCR2 and CCR5, and macrophage inflammatory protein-1alpha (MIP-1alpha/CCL3), the ligand for CCR1 and CCR5, are potent chemo-attractants in vitro and produce lesions in experimental animals, ..
  49. doi Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding
    Pia C Jensen
    Department of Neuroscience and Pharmacology, Copenhagen University, Blegdamsvej 3, DK 2200, Copenhagen, Denmark
    J Biol Chem 283:23121-8. 2008
    ..Thus, CC-chemokine receptor 1 (CCR1) binds CC-chemokine 3 and 5 (CCL3 and CCL5) with K(d) values of 7.3 and 0.16 nm, respectively, as determined in homologous competition binding assays...
  50. ncbi Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17
    M Hirashima
    Molecular Genetic Laboratory, Chemo Sero Therapeutic Research Institute, Kumamoto, Japan
    DNA Seq 3:203-12. 1992
    ..The mechanism of generation of the three LD78 genes is discussed...
  51. pmc Structures of human genes coding for cytokine LD78 and their expression
    M Nakao
    Department of Biochemistry, Kumamoto University Medical School, Japan
    Mol Cell Biol 10:3646-58. 1990
    ..mRNA phenotyping experiments revealed that the LD78 alpha and LD78 beta genes were both transcribed in PMA-stimulated U937 cells...
  52. ncbi Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
    F Cocchi
    Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA
    Science 270:1811-5. 1995
    ..These data may have relevance for the prevention and therapy of AIDS...
  53. ncbi VIP and D-ala-peptide T-amide release chemokines which prevent HIV-1 GP120-induced neuronal death
    D E Brenneman
    Section on Developmental and Molecular Pharmacology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res 838:27-36. 1999
    ..Furthermore, neuroprotection produced by chemokines is dependent on both the type of chemokine and the variant structure of gp120 and may be relevant to drug strategies for the treatment of AIDS dementia...
  54. ncbi Role of HIV-1 Tat and CC chemokine MIP-1alpha in the pathogenesis of HIV associated central nervous system disorders
    R Bonwetsch
    Department of Neurology, MCP Hahnemann University, 245 North 15th Street, Philadelphia, PA 19102, USA
    J Neurovirol 5:685-94. 1999
    ..Tat may play an important role in the pathogenesis of both HIV associated CNS disease states, acting indirectly through cytokine and chemokine dysregulation...
  55. pmc Chemokine and chemokine-receptor expression in human glial elements: induction by the HIV protein, Tat, and chemokine autoregulation
    C M McManus
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Pathol 156:1441-53. 2000
    ..These results provide evidence for the complex interplay of Tat, chemokines, and chemokine receptors in the inflammatory processes of HIV encephalitis and illustrate an important new role for chemokines as autocrine regulators...
  56. ncbi Activation of human microglial cells by HIV-1 gp41 and Tat proteins
    W S Sheng
    Department of Pharmacology, Institute for Brain and Immune Disorders, Minneapolis, Minnesota, 55404, USA
    Clin Immunol 96:243-51. 2000
    ..The results of this study suggest that HIV-1 Tat and gp41 proteins impact several key functions of microglial cells which could contribute to the neuropathogenesis of HIV-1...
  57. pmc Induction of rapid and extensive beta-chemokine synthesis in macrophages by human immunodeficiency virus type 1 and gp120, independently of their coreceptor phenotype
    W Choe
    Division of Molecular Virology, St Luke s Roosevelt Hospital Center, Columbia University, New York, New York 10019, USA
    J Virol 75:10738-45. 2001
    ..We conclude that human macrophages respond rapidly to R5 and X4 envelope binding by production of high levels of physiologically active proteins that are implicated in HIV-1 pathogenesis...
  58. ncbi Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES
    Nieves Fernández
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, and Unidad de Investigacion, Hospital Clinico Universitario, Valladolid, Spain
    J Immunol 169:3321-8. 2002
    ....
  59. ncbi Macrophage inflammatory protein-1
    Patricia Menten
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, Minderbroedersstraat 10, B 3000, Leuven Belgium
    Cytokine Growth Factor Rev 13:455-81. 2002
    ..Since both human MIP-1alpha subtypes (LD78alpha and LD78beta) and MIP-1beta signal through CCR5, the major co-receptor for M-tropic HIV-1 strains, these ..
  60. ncbi Macrophage inflammatory protein 1-alpha (MIP-1 alpha ) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells
    Suzanne Lentzsch
    University Medical Center Charite, Department of Hematology, Oncology and Tumorimmunology, Robert Rossle Klinik, Campus Buch, Humboldt University, Berlin, Germany
    Blood 101:3568-73. 2003
    ....
  61. ncbi Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor
    Raffaella Bonecchi
    Department of Biomedical Sciences and Biotechnology, Section of General Pathology and Immunology, University of Brescia, Brescia, Italy
    J Immunol 172:4972-6. 2004
    ..By recognizing intact CCL22, but not its truncated variants, D6 expressed on lymphatic endothelial cells may regulate the traffic of CCR4-expressing cells, such as dendritic cells...
  62. ncbi HIV tat and neurotoxicity
    J E King
    Department of Pathology, F727, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Microbes Infect 8:1347-57. 2006
    ..This review discusses the most recent data addressing tat-induced neurotoxicity and integrates these new findings in the context of NeuroAIDS...
  63. doi CCL3 (MIP-1 alpha) levels are elevated during acute coronary syndromes and show strong prognostic power for future ischemic events
    Saskia C A de Jager
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, PO Box 9502, 2300 RA Leiden, Leiden, The Netherlands
    J Mol Cell Cardiol 45:446-52. 2008
    ..Levels of CCL3 were prospectively verified in 54 patients with unstable angina pectoris (UAP)...
  64. doi Identification of new variants within the two functional genes CCL3 and CCL3L encoding the CCL3 (MIP-1alpha) chemokine: implications for HIV-1 infection
    M Paximadis
    AIDS Virus Research Unit, National Institute for Communicable Diseases, and Department of Virology, University of the Witwatersrand, Johannesburg, South Africa
    Int J Immunogenet 36:21-32. 2009
    The CC chemokine CCL3 is encoded by two functional genes, namely CCL3 and CCL3L, and has been identified as a key chemokine in HIV-1 susceptibility and disease progression...
  65. pmc beta-Chemokine production by neural and glial progenitor cells is enhanced by HIV-1 Tat: effects on microglial migration
    Yun Kyung Hahn
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia 23298 0709, USA
    J Neurochem 114:97-109. 2010
    ..The beta-chemokines CCL5/regulated upon activation, normal T cell expressed and secreted, CCL3/macrophage inflammatory protein-1alpha, and CCL4/macrophage inflammatory protein-1beta were increased by 12-h ..
  66. ncbi Inhibition of macrophage inflammatory protein-1 alpha production by Epstein-Barr virus
    Wolfram J Jabs
    First Department of Medicine, Division of Nephrology, University of Lübeck School of Medicine, Lubeck, Germany
    Blood 99:1512-6. 2002
    ..In summary, we demonstrate a new immunomodulating activity of EBV on the chemokine system that probably helps the virus to evade the host's immune system favoring lifelong infection...
  67. ncbi MCP-1 and MIP-1A gene polymorphisms in Japanese patients with sarcoidosis
    Toshinori Takada
    Division of Respiratory Medicine, Graduate School of Medical and Dental Sciences, Niigata University
    Intern Med 41:813-8. 2002
    ..We investigated the relationships between the polymorphisms and susceptibility to sarcoidosis, clinical manifestations, and BALF findings of sarcoidosis...
  68. ncbi A310 helical turn is essential for the proliferation-inhibiting properties of macrophage inflammatory protein-1 alpha (CCL3)
    Katrin Ottersbach
    Division of Immunology, Infection and Inflammation, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland, United Kingdom
    Blood 107:1284-91. 2006
    ..Despite possessing marked structural similarities, the chemokines macrophage inflammatory protein-1alpha (MIP-1alpha; CCL3) and RANTES (CCL5) display differential activity in hematopoietic progenitor-cell-inhibitory assays, with MIP-..
  69. ncbi Monocyte chemotactic protein-1 in the follicle of the menstrual and IVF cycle
    Pernilla Dahm-Kähler
    Department of Obstetrics and Gynecology, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Mol Hum Reprod 12:1-6. 2006
    ..GLCs secreted MCP-1 under basal conditions and also MIP-1alpha after IL-1beta stimulation. The macrophage-specific chemokine MCP-1 is highly expressed and is induced by IL-1 in the theca layer of the human follicle at ovulation...
  70. doi TLR activation pathways in HIV-1-exposed seronegative individuals
    Mara Biasin
    Cattedra di Immunologia, Universita degli Studi di Milano, Milan, Italy
    J Immunol 184:2710-7. 2010
    ..and ssRNA40 stimulation, associated with significantly increased production of IL-1beta, IL-6, TNF-alpha, and CCL3; 3) augmented expression of mRNA specific for other targets (CCL2, CSF3, CSF2, IL-1alpha, IL-8, IL-10, IL-12, ..
  71. ncbi Neonatal natural killer cells produce chemokines and suppress HIV replication in vitro
    Helene B Bernstein
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20814, USA
    AIDS Res Hum Retroviruses 20:1189-95. 2004
    ..Our results show that nNK cells can inhibit HIV replication via a chemokine-mediated mechanism, and support a potential role for the innate immune system in preventing perinatal transmission of HIV in a noncytolytic manner...
  72. ncbi Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3
    A Ben-Baruch
    Laboratory of Molecular Immunoregulation, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    J Biol Chem 270:22123-8. 1995
    ..Since MCP3 has been reported to use MCP1 receptor(s), our results with transfected 293 cells expressing only C-C CKR1 clearly establish that C-C CKR1 is also a functional receptor for MCP3...
  73. ncbi Macrophage inflammatory protein-1 alpha production in lipopolysaccharide-stimulated human adherent blood mononuclear cells is inhibited by the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine
    H Muhl
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
    J Immunol 159:5063-9. 1997
    ....
  74. ncbi Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1
    S Zhang
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 162:4938-42. 1999
    ..2 nM and 1.1 nM, respectively. We conclude that CCR1 is a receptor mediating responses to both MIP-1 alpha and Lkn-1 on neutrophils and produces different biological responses depending on the ligand bound...
  75. ncbi Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5
    G Franchin
    Picower Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 164:2592-601. 2000
    ..Taken together, our results suggest a novel pathway of CCR5 recycling in LPS-stimulated human macrophages that might be targeted to control HIV-1 infection...
  76. pmc Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells
    Manuela Del Corno
    Istituto Superiore di Sanita, Department of Cell Biology and Neurosciences, Viale Regina Elena 299, 00161 Rome, Italy
    J Virol 79:12597-601. 2005
    ..virus type 1 or gp120, but not gp41, triggered alpha interferon (IFN-alpha), CC chemokine ligand 2 (CCL2), CCL3, and CCL4 production in human plasmacytoid dendritic cells (DCs) but not in myeloid DCs (M-DCs) or monocyte-derived ..
  77. ncbi Lipopolysaccharide from an Escherichia coli htrB msbB mutant induces high levels of MIP-1 alpha and MIP-1 beta secretion without inducing TNF-alpha and IL-1 beta
    D M Hone
    Division of Basic Science, Institute of Human Virology, Baltimore, Maryland 21201, USA
    J Hum Virol 1:251-6. 1998
    ..To identify a lipopolysaccharide (LPS) that retains the capacity to induce beta-chemokine secretion without the concomitant activation of pyrogenic cytokines...
  78. ncbi IL-1 activation of endothelium supports VLA-4 (CD49d/CD29)-mediated monocyte transendothelial migration to C5a, MIP-1 alpha, RANTES, and PAF but inhibits migration to MCP-1: a regulatory role for endothelium-derived MCP-1
    H E Chuluyan
    Department of Pediatrics, Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Leukoc Biol 58:71-9. 1995
    ..abstract truncated at 250 words)..
  79. ncbi New developments in anti-HIV chemotherapy
    E De Clercq
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    Curr Med Chem 8:1543-72. 2001
    ....
  80. ncbi Serum profiles of C-C chemokines in acute myocardial infarction: possible implication in postinfarction left ventricular remodeling
    John T Parissis
    First Department of Cardiology, Amalia Fleming Hospital, Athens, Greece
    J Interferon Cytokine Res 22:223-9. 2002
    ..The elevation of these chemotactic inflammatory factors may actively contribute to the pathophysiology of the disease and the subsequent left ventricular remodeling...
  81. ncbi The urokinase-type plasminogen activator/its soluble receptor system is independently related to carotid atherosclerosis and associated with CC-chemokines in uraemic patients
    Krystyna Pawlak
    Department of Monitored Pharmacotherapy, Medical University of Bialystok, Mickiewicza 2C Street, 15 089 Bialystok, Poland
    Thromb Res 122:328-35. 2008
    ..We try to establish whether these two systems were associated among themselves, and the significance of this potential association in relation to carotid atherosclerosis in uraemic patients...
  82. pmc RANTES and macrophage inflammatory protein 1 alpha induce the migration and activation of normal human eosinophil granulocytes
    A Rot
    Institute of Clinical Immunology, Bern, Switzerland
    J Exp Med 176:1489-95. 1992
    ..intercrine/chemokine superfamily of cytokines (monocyte chemotactic peptide 1 [MCP-1], RANTES, macrophage inflammatory protein 1 alpha [MIP-1 alpha], and MIP-1 beta), which do not activate neutrophils, for their ability to affect ..
  83. ncbi Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites
    M Boll
    Institute of Toxicology, GSF National Research Center for Environment and Health, , Neuherberg, Germany
    Z Naturforsch C 56:649-59. 2001
    ..The results confirm that covalent binding of the CCl3* radical to cell components initiates the inhibition of lipoprotein secretion and thus steatosis, whereas reaction ..
  84. ncbi A study on the density and distribution of uterine Natural Killer cells at mid pregnancy in mice genetically-ablated for CCR2, CCR 5 and the CCR5 receptor ligand, MIP-1 alpha
    S Chantakru
    Department of Biomedical Sciences, Building 40 Room 2604, Ontario Veterinary College, University of Guelph, Guelph, Ont, Canada, N1G 2W1
    J Reprod Immunol 49:33-47. 2001
    ..Thus, migration, distribution and activation of NK cells within the pregnant uterus are independent of CCR2, CCR5 and MIP-1 alpha...
  85. ncbi Expression and regulation of the macrophage inflammatory protein-1 alpha gene by nicotine in rat alveolar macrophages
    Inn Wen Chong
    Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Eur Cytokine Netw 13:242-9. 2002
    ..In addition, the increase in MIP-1 alpha mRNA level involves, both transcriptional activation and post-transcriptional stabilization...
  86. doi Cytokine and chemokine responses in adults, newborns and children exposed to Entamoeba histolytica/dispar, Onchocerca volvulus and Plasmodium falciparum
    Lars Kocherscheidt
    Institute for Tropical Medicine, University Clinics of Tübingen, Wilhelmstr, Tubingen, Germany
    Pediatr Allergy Immunol 21:e756-63. 2010
    ..responses, Interferon (IFN)gamma and regulatory IL-10 were investigated, along with the chemokines MIP-1 alpha/CCL3, MIP-1 beta/CCL4, MDC/CCL22 and TARC/CCL17...
  87. pmc C-C chemokines differentially alter interleukin-4 production from lymphocytes
    N W Lukacs
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109 0602, USA
    Am J Pathol 150:1861-8. 1997
    ..These results suggest that the production of C-C chemokines (MCP-1 or MIP-1 alpha) during an immune response may aid in determining the type of cytokines produced and the level of lymphocyte activation during a particular response...
  88. ncbi Identification of cell types producing RANTES, MIP-1 alpha and MIP-1 beta in rat experimental autoimmune encephalomyelitis by in situ hybridization
    R Miyagishi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    J Neuroimmunol 77:17-26. 1997
    ..Our observations support the possibility that chemokine production by T-cells, macrophages and astrocytes lead to the infiltration of inflammatory cells into the CNS parenchyma during the acute phase of EAE...
  89. ncbi Carotid atherosclerosis is associated with enhanced beta-chemokine levels in patients on continuous ambulatory peritoneal dialysis
    Krystyna Pawlak
    Department of Nephrology and Clinical Transplantation, Medical University, 14 Zurawia St, 15 540 Bialystok, Poland
    Atherosclerosis 186:146-51. 2006
    ..protein (hs CRP); beta-chemokines: monocyte chemoattractant protein-1 (CCL2), macrophage inflammatory proteins (CCL3 and CCL4) and regulated upon activation, normal T cell expressed and secreted (CCL5) and the intima-media thickness ..
  90. doi Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis
    Hiromi Shinoda
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Respiration 78:285-92. 2009
    ..CC chemokines play important roles in the pathogenesis of interstitial lung diseases. Elevated CC chemokine levels have been observed in bronchoalveolar lavage (BAL) fluid of patients with idiopathic pulmonary fibrosis (IPF)...
  91. ncbi Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern
    V Kodelja
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    J Immunol 160:1411-8. 1998
    ....
  92. doi Increased Th1, Th17 and pro-fibrotic responses in hepatitis C-infected patients are down-regulated after 12 weeks of treatment with pegylated interferon plus ribavirin
    Maria Angeles Jimenez-Sousa
    Clinical Analysis Service, Hospital Clinico Universitario, Valladolid, Spain
    Eur Cytokine Netw 21:84-91. 2010
    ..These results provide an opportunity to evaluate the impact of the treatment with Peg-INF-alpha and RBV on the prevention of immune-driven tissue damage in infected patients...
  93. ncbi Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway
    Carmen Penido
    Laboratório de Farmacologia Aplicada, Departamento de Farmacologia Aplicada, Farmanguinhos, Fundacao Oswaldo Cruz, Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro, RJ, CEP 21041 250, Brazil
    Int Immunol 20:129-39. 2008
    ..CCL)-2/monocyte chemotactic protein-1, CCL5/regulated upon activation, normal T cell expressed and secreted, CCL3/macrophage inflammatory protein-1 alpha and CCL25/thymus-expressed chemokine were above control values in pleural ..
  94. ncbi Eotaxin stimulates eosinophil adhesion to human lung microvascular endothelial cells
    A Burke-Gaffney
    National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, United Kingdom
    Biochem Biophys Res Commun 227:35-40. 1996
    ..These results suggest that eotaxin may facilitate eosinophil migration from blood vessels in the lung by increasing eosinophil adhesion to endothelial cells...
  95. ncbi Macrophage inflammatory protein-1 alpha is a critical mediator of host defense against invasive pulmonary aspergillosis in neutropenic hosts
    B Mehrad
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 165:962-8. 2000
    ..These studies indicate that MIP-1 alpha is a critical mediator of host defense against A. fumigatus in the setting of neutropenia and may be an important target in devising future therapeutic strategies against invasive aspergillosis...
  96. ncbi Response of hematopoiesis to cyclophosphamide follows highly specific patterns in bone marrow and spleen
    Ludek Sefc
    Institute of Pathophysiology, First Faculty of Medicine, Charles University, Prague, Czech Republic
    J Hematother Stem Cell Res 12:47-61. 2003
    ..This represents a significant challenge to experimental hematology, which could now be tackled with methods allowing the study of changes in the gene expression during cyclophosphamide-induced hematopoietic damage...
  97. ncbi Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor
    J L Gao
    Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 270:17494-501. 1995
    ..These data identify potentially important new targets for beta chemokine action in the mouse...
  98. pmc HCC-1, a novel chemokine from human plasma
    P Schulz-Knappe
    Lower Saxony Institute for Peptide Research IPF, Hannover, Germany
    J Exp Med 183:295-9. 1996
    ..In addition, HCC-1 enhanced the proliferation of CD34+ myeloid progenitor cells. It was as effective as MIP-1 alpha, but about 100-fold less potent...
  99. doi Echinococcus multilocularis: inflammatory and regulatory chemokine responses in patients with progressive, stable and cured alveolar echinococcosis
    Lars Kocherscheidt
    Institute for Tropical Medicine, University of Tubingen, Wilhelmstrasse 27, 72074 Tubingen, Germany
    Exp Parasitol 119:467-74. 2008
    ..multilocularis antigens. The production of CC and CXC chemokines which associate with inflammation (MIP-1 alpha/CCL3, MIP-1 beta/CCL4, RANTES/CCL5 and GRO-alpha/CXCL1) was constitutively larger in AE patients than in controls; and ..
  100. ncbi CC and CXC chemokines are differentially expressed in erythema multiforme in vivo
    Ulrich Spandau
    Department of Ophthalmology, University of Wurzburg Medical School, Germany
    Arch Dermatol 138:1027-33. 2002
    ..A characteristic feature of erythema multiforme is an acute inflammatory reaction of the skin with an infiltrate largely composed of mononuclear cells around the upper dermal vessels and in the dermal-epidermal interface...
  101. ncbi Chemokine receptor (CCR5) expression in human kidneys and in the HIV infected macaque
    F Eitner
    Department of Pathology, University of Washington, Seattle, USA
    Kidney Int 54:1945-54. 1998
    ..The localization of CCR5 in human or primate kidney is unknown. In this study we sought to identify sites of CCR5 synthesis through localization of mRNA coding for this peptide...

Research Grants56

  1. Inhibition of CCR1/CCR5 mediated angiogenesis and joint destruction by EGCG
    Salah Uddin Ahmed; Fiscal Year: 2010
    ..Importantly, RANTES/CCL5 and macrophage inflammatory protein (MIP-11)/CCL3 are the chemokines shown to activate CCR1 and CCR5 receptor to attract T cells and monocytes into joints during the ..
  2. Selective Delivery of a novel bacterial adjuvant for multipurpose vaccination
    GREGOIRE STEPHANE LAUVAU; Fiscal Year: 2013
    ..Using this model system, we established that secretion of the proinflammatory chemokine CCL3 / MIP-1a (Macrophage Inflammatory Protein 1a) by memory CD8+ T cells early during secondary challenge infection is ..
  3. STRUCTURE AND FUNCTION OF I-309 AND OTHER CHEMOKINES
    MICHAEL KRANGEL; Fiscal Year: 2000
    ..Finally, they propose to define I-309 receptors on monocytes by performing direct and competition binding experiments and by screening cloned and expressed "orphan receptors". ..
  4. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..Additionally, chemokines (CCL3/MIP-11, CCL4/MIP-12, CXCL9/MIG, CXCL10/IP-10, CXCL12/SDF, and CCL5/RANTES) within these tissues will be examined to ..
  5. Priya Pal; Fiscal Year: 2015
    ..Cerebral malaria is marked by a pro-inflammatory environment, including an increase in chemokines CXCL9,10,11 and CCL3,4,5...
  6. In Vivo Brain Dialysis of Neuropeptides and Neuroimmune Signaling Proteins
    Julie A Stenken; Fiscal Year: 2012
    ..focus will be on a select group of cytokines and neuropeptides related to epilepsy (cytokines {CCL2 [MCP-1], CCL3 [MIP-1a], CCL4 [MIP-12], CCL5 [RANTES], KC/GRO, IL-1b, IL-6, IL-10, and TNF-a} and neuropeptides {angiotensin IV, 2-..
  7. Sulie L Chang; Fiscal Year: 2014
    ..using PCR array analysis, we showed that the pro- inflammatory cytokine, IL-1[unreadable], as well as the Ccl2, Ccl3, and Ccl7 chemokines, are increased to a greater extent in the brain of the HIV-1Tg rat compared to the F344 ..
  8. Wei Jen Tang; Fiscal Year: 2015
    ..A?, and other functionally relevant substrates such as natriuretic peptides and proinflammatory chemokines, CCL3/CCL4. IDE has two 55 kDa domains, which form an enclosed catalytic chamber to entrap its substrates...
  9. GREGOIRE STEPHANE LAUVAU; Fiscal Year: 2016
    ..memory CD8+ T cells with the capacity to protect against lethal infection secreted the proinflammatory chemokine CCL3/MIP1 upon recognition of their cognate antigen, a feature that was lacking in memory cells from non-protected ..
  10. ALEX YEE CHEN HUANG; Fiscal Year: 2015
    ..Using animal tumor models genetically engineered to secrete inflammatory chemokines such as CCL3 and CCL4, we propose to undertake a series of studies to investigate how efficient cell-cell interaction among ..
  11. CHEMOKINE SECRETING CD8 T CELL SUBSETS IN HIV INFECTION
    Fiorenza Cocchi; Fiscal Year: 1999
    ..Correlation of the magnitude of any observed impairment with disease progression will validate the hypothesis. ..
  12. HIV CORECEPTORS EXPRESSED BY GLIAL CELLS
    Martin Dorf; Fiscal Year: 2000
    ..Although astrocytes have CXCR4, they do not appear to respond with chemotaxis after stimulation with the CXCR4 ligand, the chemokine SDF-1. ..
  13. Richard L Stouffer; Fiscal Year: 2015
    ..Aims 2 and 3), and intra-luteal infusion of monocyte/neutrophil selective, chemokine-receptor (CCL2/MCP1-CCR2 and CCL3/MIP11 - CCR3) antagonists (Aim 3)...
  14. Akiko Maeda; Fiscal Year: 2016
    ..Aim 2 will test the hypothesis that CCL3 is a major chemokine that mediates recruitment of inflammatory cells to the subretinal space in retinal ..
  15. Kevin D Cooper; Fiscal Year: 2014
    ..suppress in developed psoriatic lesions, have decreased numbers of CCR5+ Tregs, decreased chemotaxis to Rantes and Mip1a, decreased CD73, and increased IFI27 (ISG12)...
  16. Extra-Fine Inhaled Corticosteroid Effect on Distal Lung Disease in Asthma
    Michelle Zeidler; Fiscal Year: 2007
    ..This study will determine the potential to modify distal airways inflammation which may ultimately improve asthma control. [unreadable] [unreadable]..
  17. NOVEL ANTI-INFLAMMATORY THERAPY FOR PSORIASIS
    Andrew Salzman; Fiscal Year: 1999
    ..PROPOSED COMMERCIAL APPLICATIONS: The domestic market for a novel, effective therapy for psoriasis is estimated at> 2 billion per annum. Global markets are estimated at $10 billion. ..
  18. CD8+ T CELLS IN PRIMARY INFECTION
    Roberta Kamin Lewis; Fiscal Year: 1999
    ..2) To characterize this subset for the productions of other beta chemokines such as MIP 1 alpha and RANTES, inflammatory cytokines, and the cytoplasmic proteins granzyme A and B...
  19. Role of cytokines in retroviral neuropathogenesis
    Karin Peterson; Fiscal Year: 2005
    ..Therefore, we will also analyze how infected microglia cells regulate TNF alpha and MCP-1production, in vivo. ..
  20. NEURONAL ACTIONS OF HOST FACTORS IN NEUROAIDS
    DONNA GRUOL; Fiscal Year: 2005
    ..The overall design will address effects of both acute and chronic chemokine exposure on neuronal cell function and will include examination of two distinct classes of neurons, excitatory glutamatergic and inhibitory GABAergic neurons. ..
  21. MODULATING BETA CHEMOKINES WITHIN THE LYMPHATIC CIRCULAT
    Sunil Shaunak; Fiscal Year: 1999
    ....
  22. Host Genetic Epidemiology in HIV-1-Discordant African Couples and Other Cohorts
    Jianming Tang; Fiscal Year: 2012
    ..aim covers genes in the pathway for expression of the HIV-1 chemokine co-receptor and its ligands (CCR2, CCR5, CCL3, CCL3L1, CCL4, CCL4L1, and CCL5). Related new candidate genes will be considered...
  23. Jose R Conejo-Garcia; Fiscal Year: 2016
    ..in turn produce IL-6 that drives irreversible dedifferentiation and subsequent oncogenic transformation, and also CCL3 that eventually induces the exponential accumulation of more inflammatory DCs...
  24. Laura M Calvi; Fiscal Year: 2016
    ..Moreover, we discovered leukemic production of the chemokine CCL3, recently demonstrated to inhibit osteoblastic function in multiple myeloma...
  25. TOXINS AND HEPATOCELLULAR PHOSPHOGLYCERIDE CATABOLISM
    ROBERT LAMB; Fiscal Year: 1990
    ..b>CCl3). Yet, the mechanism(s) by which .CCl3 causes cell death are still unresolved...
  26. PROTECTIVE MECHANISMS WITH ATTENUATED LENTIVIRAL VACCINE
    Christopher Miller; Fiscal Year: 2002
    ..environment is due to increased expression of antiviral cytokines (IFN- a, IFN-b, IFN-g and TNF) and chemokines (MIP1a, MIPlb and Rantes)...
  27. Mechanisms of Leukocyte Recruitment During IPS After BMT
    Kenneth Cooke; Fiscal Year: 2007
    ..macrophages and neutrophils to the lung during the development of IPS: SA1: CCR5 / RANTES (CCL5) and MIP-1alpha (CCL3) --> Th1 lymphocytes --> days 7-21 SA2: CXCR3 / IP-10 (CXCL10) and Mig (CXCL9) SA3: CCR2: / MCP-1 (CCL2) --&..
  28. MOLECULAR MECHANISMS OF CHEMICAL CARCINOGENESIS
    John Wong; Fiscal Year: 1980
    ..Our questions are: a) what reactions occur between base residues and radical species such as .CCl3 and .CH3, b) how are the radicals bound to DNA, and c) what are the subsequent physicochemical changes...
  29. Mechanisms Involved in T cell trafficking in GVHD
    Jonathan Serody; Fiscal Year: 2007
    ..Our group was the first to show that a chemokine, CCL3, plays a role in the trafficking of CD8+ T cells into the liver and lung...
  30. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  31. NEUROIMMUNOLOGY OF AED IN OCULAR HSV-1 INFECTION
    Daniel Carr; Fiscal Year: 2001
    ..abstract_text> ..
  32. Anti-Viral Gene Delivery in the Nervous System
    Daniel Carr; Fiscal Year: 2005
    ..abstract_text> ..
  33. The Role of CXCL9 in Genital HSV-2 Infection
    Daniel Carr; Fiscal Year: 2009
    ..g., vaccine or gene transfer) to reduce the incidence of infection or reduce the capacity of latent virus to reactivate. ..
  34. Domoic Acid and Neonatal Microglia Activation
    Alejandro Mayer; Fiscal Year: 2004
    ..activated microglia cells and their mediators play in DOM-induced excitotoxic neuronal injury and thus contribute to potential novel approaches for the therapy of the neuropathology associated with Amnesic Shellfish Poisoning in humans ..
  35. SHIGA TOXIN INDUCED INFLAMMATION AND THROMBOSIS
    Adrian Gear; Fiscal Year: 2004
    ..Finally, the role of proteases in the Shiga-toxin effects on platelet function will be examined. ..
  36. IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASES
    Zahra Toossi; Fiscal Year: 2001
    ..3. To characterize the T-cell dysfunction of patients with active pulmonary tuberculosis, its relationship to TGF-beta and other suppressive cytokines (IL-10) and its reversal by inhibitors of TGF- beta. ..
  37. IMMUNOLOGICAL MECHANISM OF INFLAMMATION IN UVEITIS & EAE
    Grazyna Adamus; Fiscal Year: 2001
    ..3) Examine the role of cytokines and chemokines in the recruitment of cell to the eye in primary and recurrent uveitis associated with EAE after immunization of Lewis rats with MBP. ..
  38. Cell Cycle G2/M Pathway Modulated by Viral Protein R
    Richard Zhao; Fiscal Year: 2006
    ..These proposed studies will provide a comprehensive framework for this new cell cycle control pathway and provide insights into fundamental aspects of this new G2/M surveillance system of eukaryotic cells. ..
  39. NATURAL KILLER CELL TRAFFICKING AND DELIVERY OF FUNCTION
    THAIS SALAZAR MATHER; Fiscal Year: 2002
    ..Information resulting from these studies will yield significant and novel information for developing anti-viral and anticancer treatment protocols. ..
  40. Role of IL-8 in Cell Migration and Proliferation
    Ingrid Schraufstatter; Fiscal Year: 2004
    ....
  41. BREAST CANCER/BONE MARROW STROMAL INTERACTIONS
    Pranela Rameshwar; Fiscal Year: 2003
    ..Since BC metastasis involves two major cell subsets, mesenchymal (stroma) and epithelial (BC), aim 4 will determine if regulation of PPT-I, NK-1 and NK-2 is tissue specific by studying their promoters in these cell subsets. ..
  42. Elucidating Biopsychosocial Mediators of HIV Progression
    LYDIA TEMOSHOK; Fiscal Year: 2009
    ....
  43. POST BMT LUNG INJURY PATHOPHYSIOLOGY
    Angela Panoskaltsis Mortari; Fiscal Year: 2009
    ..These translatable approaches offer new avenues for the prevention and treatment of IPS. ..
  44. Dendrimer aminosaccharide drug to modulate inflammatory responses in shigellosis
    Sunil Shaunak; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  45. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  46. Lactoferrin for Immunomodulation of Systemic Inflammatory Response Syndrome
    Jeffrey Actor; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  47. Dendritics Cell Immunotherapy for Colorectal Cancer
    Lawrence Fong; Fiscal Year: 2008
    ..The proposed studies will provide the foundation for a more potent DC targeted cancer immunotherapy for the future. [unreadable] [unreadable] [unreadable]..
  48. Regulation of Cortisol by Mycobacterial Glycolipid TDM
    Jeffrey Actor; Fiscal Year: 2005
    ..abstract_text> ..
  49. Key Innate Mechanisms of Natural Killer Cell Trafficking
    THAIS SALAZAR MATHER; Fiscal Year: 2007
    ..During MCMV infections of mice the chemokine MIP-1alpha/CCL3 promotes NK cell migration and delivery of IFN-gamma at tissues sites of viral infection to mediate downstream ..
  50. Chemokine receptor antagonists in inflammatory disease
    Shiva Shahrara; Fiscal Year: 2007
    ..Achieving these goals may give us valuable information in regard to molecular inflammatory mechanisms involved in atherosclerosis and RA. ..
  51. Effect of HIV-1 Vpr on Basic Cellular Functions (II)
    Richard Zhao; Fiscal Year: 2007
    ..abstract_text> ..
  52. Recombinant T-cell Receptor Ligands for Treatment of Uveitis
    Grazyna Adamus; Fiscal Year: 2006
    ..To determine an effective treatment regimen for clinical rat AAU using RTLs. 2. To determine the abilities of RTLs to inhibit recurrent anterior and posterior uveitis in Lewis rats. [unreadable] [unreadable] [unreadable] [unreadable]..
  53. Migration of Mature and Immature Dendritic Cells
    HENDRIK VAN DEVENTER; Fiscal Year: 2006
    ..All have extensive experience in developing the careers o f young scientists. This work has the support of the Lineberger Comprehensive Cancer Center which has made accessible its core facilities. ..
  54. Vaccine hurdle to anthrax and the emerging immune system
    Pranela Rameshwar; Fiscal Year: 2006
    ..This study will also form the basis to develop in vivo model with human hematopoietic system to study anthrax infection and also to improve responses to anthrax vaccines. ..
  55. The Role of CD4 on Natural Killer Cells
    HELENE BERNSTEIN; Fiscal Year: 2006
    ....
  56. Molecular Mechanism of Acupuncture
    Gabriela Garcia; Fiscal Year: 2006
    ..We believe that our studies may open new era towards molecular understanding of acupuncture treatment in pain, inflammation, as well as a variety of vascular diseases in humans. ..