CCL28

Summary

Gene Symbol: CCL28
Description: C-C motif chemokine ligand 28
Alias: CCK1, MEC, SCYA28, C-C motif chemokine 28, CC chemokine CCL28, chemokine (C-C motif) ligand 28 splice variant chi, mucosae-associated epithelial chemokine, small inducible cytokine A28, small inducible cytokine subfamily A (Cys-Cys), member 28
Species: human

Top Publications

  1. ncbi CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity
    Kunio Hieshima
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Immunol 170:1452-61. 2003
  2. pmc CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells
    Eric J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 111:1001-10. 2003
  3. ncbi Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10
    Bertus Eksteen
    Liver Research Laboratories, Medical Research Council for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK
    J Immunol 177:593-603. 2006
  4. ncbi Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)
    W Wang
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    J Biol Chem 275:22313-23. 2000
  5. ncbi Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature
    K Triantafillidou
    Department of Oral and Maxillofacial Surgery, Dentistry School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Oral Dis 12:364-70. 2006
  6. ncbi [A case of staphylococcal scalded skin syndrome caused by exfoliative toxin-B producing MRSA]
    S Yokota
    Department of Pediatrics, Yokohama City University School of Medicine
    Kansenshogaku Zasshi 70:206-10. 1996
  7. ncbi [Isolation of Shiga toxin-producing Escherichia coli O157:H7 from processed salmon roe associated with the outbreaks in Japan, 1998, and a molecular typing of the isolates by pulsed-field gel electrophoresis]
    Y Asai
    Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratory
    Kansenshogaku Zasshi 73:20-4. 1999
  8. ncbi Molecules that mediate touch transduction in the nematode Caenorhabditis elegans
    M Driscoll
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08855, USA
    Gravit Space Biol Bull 10:33-42. 1997
  9. pmc Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function
    G L Kiser
    Molecular and Cellular Biology Department, University of Arizona, Tucson 85721, USA
    Mol Biol Cell 7:703-18. 1996
  10. ncbi Phase II trial with alternating two drug schedules, CAP/MEC', for advanced (stage III Mo/M1) non-small-cell lung cancer
    D Tummarello
    , Italy
    Tumori 75:486-8. 1989

Research Grants

  1. Defining the bacterial factors that modulate sensitivity to B-lactam in CA-MRSA
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2010
  2. METHICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 1993
  3. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    Gordon Archer; Fiscal Year: 2003
  4. Epidemiology of Putative Causal Variants in the Multiethnic Cohort
    Loic Le Marchand; Fiscal Year: 2012
  5. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
  6. Sequence Distribution of Tobacco Carcinogen-DNA Adducts
    Natalia Y Tretyakova; Fiscal Year: 2012
  7. Mechanisms of Degenerative Cell Death in C. elegans
    MONICA A DRISCOLL; Fiscal Year: 2013
  8. Jane C Figueiredo; Fiscal Year: 2015
  9. Chemosensing in the Gastrointestinal Tract
    Catia Sternini; Fiscal Year: 2010
  10. Multiethnic Cohort Study of Diet and Cancer
    Laurence N Kolonel; Fiscal Year: 2012

Patents

  1. Mammalian chemokines

Detail Information

Publications216 found, 100 shown here

  1. ncbi CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity
    Kunio Hieshima
    Department of Microbiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    J Immunol 170:1452-61. 2003
    b>CCL28 is a CC chemokine signaling via CCR10 and CCR3 that is selectively expressed in certain mucosal tissues such as exocrine glands, trachea, and colon. Notably, these tissues commonly secrete low-salt fluids...
  2. pmc CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells
    Eric J Kunkel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    J Clin Invest 111:1001-10. 2003
    ..Epithelial cells in diverse gastrointestinal and nonintestinal mucosal tissues express the chemokine MEC/CCL28. Here we demonstrate that CCR10, a receptor for MEC, is selectively expressed by IgA Ab-secreting cells (large s/..
  3. ncbi Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10
    Bertus Eksteen
    Liver Research Laboratories, Medical Research Council for Immune Regulation, Institute for Biomedical Research, University of Birmingham, Birmingham B15 2TH, UK
    J Immunol 177:593-603. 2006
    ..The CCR10+ Tregs were detected around bile ducts that expressed increased levels of the CCR10 ligand CCL28. CCL28 was secreted by primary human cholangiocytes in vitro in response to LPS, IL-1beta, or bile acids...
  4. ncbi Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)
    W Wang
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    J Biol Chem 275:22313-23. 2000
    We report the identification and characterization of a novel CC chemokine designated CCL28 and its receptor CCR10, known previously as orphan G-protein-coupled receptor GPR2...
  5. ncbi Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature
    K Triantafillidou
    Department of Oral and Maxillofacial Surgery, Dentistry School, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Oral Dis 12:364-70. 2006
    Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of salivary glands with a widely diverse biologic behavior that is correlated with the histological grade of the tumor...
  6. ncbi [A case of staphylococcal scalded skin syndrome caused by exfoliative toxin-B producing MRSA]
    S Yokota
    Department of Pediatrics, Yokohama City University School of Medicine
    Kansenshogaku Zasshi 70:206-10. 1996
    ..aureus was demonstrated to be methicillin-resistant (MRSA), which was further defined to be positive for mec A gene by PCR method...
  7. ncbi [Isolation of Shiga toxin-producing Escherichia coli O157:H7 from processed salmon roe associated with the outbreaks in Japan, 1998, and a molecular typing of the isolates by pulsed-field gel electrophoresis]
    Y Asai
    Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratory
    Kansenshogaku Zasshi 73:20-4. 1999
    ..pre-enriched in trypticase soy broth (TSB) at 36 degrees C for 6 h and novobiocin-supplemented modified EC broth (mEC-NB) at 42 degrees C for 18 h...
  8. ncbi Molecules that mediate touch transduction in the nematode Caenorhabditis elegans
    M Driscoll
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08855, USA
    Gravit Space Biol Bull 10:33-42. 1997
    ..b>mec-4 and mec-10 encode members of a C...
  9. pmc Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function
    G L Kiser
    Molecular and Cellular Biology Department, University of Arizona, Tucson 85721, USA
    Mol Biol Cell 7:703-18. 1996
    ..The conclusion that the yeast MEC1 gene is a key regulator also has implications for the role of a putative human homologue, the ATM gene...
  10. ncbi Phase II trial with alternating two drug schedules, CAP/MEC', for advanced (stage III Mo/M1) non-small-cell lung cancer
    D Tummarello
    , Italy
    Tumori 75:486-8. 1989
    ..The combinations were cisplatin, adriamycin and cyclophosphamide (CAP) and methotrexate, etoposide and CCNU (MEC')...
  11. ncbi Cholinergic regulation of the central nucleus of the amygdala in rats: effects of local microinjections of cholinomimetics and cholinergic antagonists on arousal and sleep
    L D Sanford
    Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, P O Box 1980, Norfolk, VA 23501, USA
    Neuroscience 141:2167-76. 2006
    ..3 microg; SCO(H): 1.0 microg), the nicotinic antagonist, mecamylamine (MEC(L): 0.3 microg; MEC(H): 1.0 microg) and saline (SAL, 0.2 microl) alone...
  12. doi Differences between "classical" risk factors for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and risk factors for nosocomial bloodstream infections caused by multiple clones of the staphylococcal cassette chromosome mec type IV
    Paula M Vidal
    Department of Infectious Diseases and Hospital Infection Control, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, Brazil
    Infect Control Hosp Epidemiol 30:139-45. 2009
    To identify risk factors associated with nosocomial bloodstream infections caused by multiple clones of the staphylococcal cassette chromosome mec (SCCmec) type IV strain of methicillin-resistant Staphylococcus aureus (MRSA).
  13. doi Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior
    Alexander Kuzmin
    Department of Clinical Neuroscience, Division of Drug Dependence, Karolinska University Hospital, Bldg M1 01, 17176, Stockholm, Sweden
    Psychopharmacology (Berl) 203:99-108. 2009
    ..MII (alphaCtxMII, alpha(3)beta(2)*, beta(3)*, alpha(6)*), were compared to those of systemic mecamylamine (MEC, an allosteric negative modulator of the nAChR), dihydro-beta-erythroidine (DHbetaE, alpha(4)beta(2)*), and ..
  14. ncbi Intracerebroventricular administration of PD 140.548 N-methyl-D-glucamine attenuates the release of cortisol and catecholamines induced by duodenal distension in the sheep
    B F Kania
    Experimental and Clinical Physio Pharmacological Laboratory, Department of Physiological Sciences, Faculty of Veterinary Medicine, Agricultural University of Warsaw, Poland
    Pol J Vet Sci 8:183-93. 2005
    ..548 N-methyl-D-glucamine (a specific peptide antagonist of a CCK1 receptor) premedication on mechanographical reticulo-ruminal activity, animal general behaviour, catecholamines (CA)..
  15. ncbi Efficacy of enrichment broths in the recovery of freeze-injured Escherichia coli O157:H7 in inoculated ground beef by PCR
    W C Lionberg
    R and F Laboratories, 245 West Roosevelt Road, Building 3, Unit 16, West Chicago, Illinois 60185, USA
    J Food Prot 66:1911-5. 2003
    ..peptone water with vancomycin, cefsulodin, and cefixime (BPW-VCC), 225 ml of modified EC broth plus novobiocin (mEC+n), and 225 ml of R&F enrichment broth (R&F-EB) and aerobically incubated at 41 to 42 degrees C...
  16. ncbi [Epidemiology of cognitive deterioration in the institutionalized geriatric population of the socio-sanitary centers in the city of Barcelona]
    M Boada
    , Hospital General Vall d Hebron, Barcelona
    Rev Neurol 23:174-80. 1995
    ..The age, the fact that the patients were female, illiteracy and working as house-wives all made for low MEC ratings...
  17. doi Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion
    Jochen K M Lennerz
    Divisions of Anatomic and Molecular Pathology, Washington University Medical Center, St Louis, MO, USA
    Am J Surg Pathol 33:835-43. 2009
    Mucoepidermoid carcinoma (MEC) of the uterine cervix is a controversial entity...
  18. ncbi Pharmacokinetics of dexloxiglumide after administration of single and repeat oral escalating doses in healthy young males
    S Persiani
    Rotta Research Laboratorium, Monza, Italy
    Int J Clin Pharmacol Ther 40:198-206. 2002
    To assess the pharmacokinetics, safety and tolerability of dexloxiglumide, a new CCK1 receptor antagonist currently under development for the treatment of the constipation-predominant irritable bowel syndrome.
  19. ncbi beta-Catenin nuclear accumulation in head and neck mucoepidermoid carcinoma: its role in cyclin D1 overexpression and tumor progression
    Hideki Shiratsuchi
    Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Head Neck 29:577-84. 2007
    ..and cyclin D1 in this pathway has not been previously studied in head and neck mucoepidermoid carcinoma (MEC)...
  20. pmc A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort
    Sulggi A Lee
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles, CA, USA
    BMC Med Genet 8:72. 2007
    ..Prospective epidemiological studies have also shown that women with higher circulating PRL levels have an increase in risk of breast cancer, suggesting that variability in PRL may also be important in determining a woman's risk...
  21. doi The origin of a methicillin-resistant Staphylococcus aureus isolate at a neonatal ward in Sweden-possible horizontal transfer of a staphylococcal cassette chromosome mec between methicillin-resistant Staphylococcus haemolyticus and Staphylococcus aureus
    C Berglund
    Department of Clinical Microbiology, Orebro University Hospital, Orebro, Sweden
    Clin Microbiol Infect 14:1048-56. 2008
    ..methicillin-resistant Staphylococcus aureus (MRSA) strain originated when a staphylococcal cassette chromosome mec (SCCmec) with the gene mecA was integrated into the chromosome of a susceptible S. aureus cell...
  22. doi Phase 2 trial results with the novel neurokinin-1 receptor antagonist casopitant in combination with ondansetron and dexamethasone for the prevention of chemotherapy-induced nausea and vomiting in cancer patients receiving moderately emetogenic chemothera
    Wichit Arpornwirat
    Department of Medicine, National Cancer Institute, Bangkok, Thailand
    Cancer 115:5807-16. 2009
    ..the neurokinin-1 receptor antagonist casopitant mesylate in combination with ondansetron/dexamethasone (ond/dex) for the prevention of chemotherapy-induced nausea and vomiting (CINV) related to moderately emetogenic chemotherapy (MEC).
  23. pmc Identification in methicillin-susceptible Staphylococcus hominis of an active primordial mobile genetic element for the staphylococcal cassette chromosome mec of methicillin-resistant Staphylococcus aureus
    Yuki Katayama
    Department of Bacteriology, Faculty of Medicine, Juntendo University, Tokyo, Japan
    J Bacteriol 185:2711-22. 2003
    ..gene mecA is carried by a novel type of mobile genetic element, SCCmec (staphylococcal cassette chromosome mec), in the chromosome of methicillin-resistant Staphylococcus aureus (MRSA)...
  24. doi New developments in the molecular pathogenesis of head and neck tumors: a review of tumor-specific fusion oncogenes in mucoepidermoid carcinoma, adenoid cystic carcinoma, and NUT midline carcinoma
    Feriyl Bhaijee
    Department of Pathology, The University of Mississippi Medical Center, Jackson, MS 39216, USA
    Ann Diagn Pathol 15:69-77. 2011
    ..been identified in various uncommon, aggressive head and neck malignancies, including mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and NUT midline carcinoma (NMC)...
  25. doi Palonosetron versus other 5-HT₃ receptor antagonists for prevention of chemotherapy-induced nausea and vomiting in patients with hematologic malignancies treated with emetogenic chemotherapy in a hospital outpatient setting in the United States
    Chris Craver
    Premier Inc, 2320 Cascade Pointe Blvd, Charlotte, NC, USA
    J Med Econ 14:341-9. 2011
    ..receptor antagonists (RAs) in patients diagnosed with hematologic malignancies (lymphoma and leukemia) and receiving highly emetogenic chemotherapy (HEC) or moderately emetogenic chemotherapy (MEC) in a hospital outpatient setting.
  26. pmc The RNA moiety of chick embryo 5-methylcytosine- DNA glycosylase targets DNA demethylation
    J P Jost
    Friedrich Miescher Institute, PO Box 2543, CH 4002 Basel, Switzerland
    Nucleic Acids Res 25:4545-50. 1997
    We have previously shown that DNA demethylation by chick embryo 5-methylcytosine (5-MeC)-DNA glycosylase needs both protein and RNA. RNA from enzyme purified by SDS-PAGE was isolated and cloned...
  27. ncbi Different pathways mediated by CCK1 and CCK2 receptors: effect of intraperitonal mrna antisense oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats
    Hagit Cohen
    Ministry of Health Mental Health Center, Anxiety and Stress Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Depress Anxiety 20:139-52. 2004
    ..p.) administration of ASODN to preproCCK in the presence of antagonists to CCK1 and CCK2 receptor subtypes to further elucidate the roles of these two receptors and better understand the effects ..
  28. ncbi Evaluation of the pear ester kairomone as a formulation additive for the granulovirus of codling moth (Lepidoptera: Tortricidae) in pome fruit
    S P Arthurs
    USDA ARS, Yakima Agricultural Research Laboratory, 5230 Konnowac Pass Rd, Wapato, WA 98951, USA
    J Econ Entomol 100:702-9. 2007
    ..to evaluate a 5% active ingredient (AI), microencapsulated formulation of pear ester (PE-MEC) as an insecticidal additive for the codling moth granulovirus (CpGV)...
  29. doi Diversity of staphylococcal cassette chromosome mec structures in coagulase-negative staphylococci and relationship to drug resistance
    Elvira Garza-Gonzalez
    Departamento de Microbiologia, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Monterrey Nuevo Leon 64460, Mexico
    J Med Microbiol 59:323-9. 2010
    The objective of this study was to determine the distribution of staphylococcal cassette chromosome mec (SCCmec) elements in meticillin-resistant coagulase-negative staphylococci (MR-CoNS) isolated from a tertiary-care hospital in Mexico ..
  30. doi Detection of biofilm-producing and methicillin resistance genes in Staphylococcus epidermidis isolated from healthy humans and in blood culture tests
    Takashi Kitao
    Ehime Prefectural University of Health Sciences, Tobecho, Iyogun, Ehime, Japan
    J Infect Chemother 16:170-3. 2010
    The detection of biofilm-producing (ica AB) and methicillin resistance genes (mec A) was investigated in 70 blood culture isolates of Staphylococcus epidermidis and in 66 and 51 isolates from human hands and the vestibules of the nose, ..
  31. ncbi Relationship between meconium staining and amniotic fluid volume in term pregnancies
    Sean C Blackwell
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA
    Fetal Diagn Ther 17:78-82. 2002
    Our purpose was to evaluate the relationship between meconium-stained amniotic fluid (MEC-AF) and amniotic fluid volume (AFV) and their impact on the risk of cesarean delivery for fetal indications in term pregnancies.
  32. ncbi SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. I. In vitro studies
    E Bignon
    Sanofi Recherche, Toulouse Cedex, France
    J Pharmacol Exp Ther 289:742-51. 1999
    ..Hunter (BH)-sulfated cholecystokinin octapeptide (CCK-8S) for the human recombinant cholecystokinin subtype 1 (CCK1) receptor (IC50 = 0.56 nM) with high (300-fold) selectivity to the CCK2 receptor...
  33. ncbi Distribution of staphylococcal cassette chromosome mec (SCCmec) types I, II, III and IV in coagulase-negative staphylococci from patients attending a tertiary hospital in southern Brazil
    Alice Beatriz Mombach Pinheiro Machado
    Unidade de Microbiologia e Biologia Molecular, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90 035 903, Brazil
    J Med Microbiol 56:1328-33. 2007
    ..Staphylococcal cassette chromosome mec (SCCmec) typing is essential for understanding the molecular epidemiology of meticillin-resistant Staphylococcus ..
  34. doi Critical roles of mecamylamine-sensitive mushroom body neurons in insect olfactory learning
    Hidehiro Watanabe
    Graduate School of Life Sciences, Tohoku University, Sendai 980 8577, Japan
    Neurobiol Learn Mem 95:1-13. 2011
    ..In cockroaches, a type of nicotinic ACh receptor specifically antagonized by mecamylamine (MEC) has been characterized...
  35. ncbi Estrogen receptor-alpha and -beta expression in microvascular endothelial cells and smooth muscle cells of myometrium and leiomyoma
    Caroline E Gargett
    Centre for Women s Health Research, Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, Clayton, Victoria, Australia
    Mol Hum Reprod 8:770-5. 2002
    ..aims of the present study were to determine whether pure populations of myometrial microvascular endothelial cells (MEC) express ERalpha and ERbeta, to compare MEC ERalpha/ERbeta expression with that of pure populations of myometrial ..
  36. doi Reactivity of ammonia ligands of the antitumor agent cisplatin: a unique dodecanuclear Pt4,Pd4,Ag4 platform for four cytosine model nucleobases
    Gunnar Kampf
    Fakultat Chemie, Technische Universitat Dortmund, Otto Hahn Strasse 6, Dortmund, Germany
    Chemistry 14:6882-91. 2008
    The reaction of a potential mono(nucleobase) model adduct of cisplatin, cis-[Pt(NH(3))(2)(1-MeC-N3)(H(2)O)](2+) (6; 1-MeC: 1-methylcytosine), with the electrophile [Pd(en)(H(2)O)(2)](2+) (en: ethylenediamine) at pH approximately 6 yields ..
  37. ncbi [Epidemiology of cognitive deterioration in geriatric population of 'Casals d' Avis' in the city of Barcelona]
    M Boada
    , , Barcelona
    Rev Neurol 23:166-73. 1995
    ..67%. Age, female sex, being widowed or single, and illiteracy are associated with low scoring in the MEC. It is also associated with subjective loss of memory and hearing difficulties...
  38. pmc Molecular cloning, expression and pharmacological characterization of the canine cholecystokinin 1 receptor
    Magda Francesca Morton
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Br J Pharmacol 145:374-84. 2005
    1 The full-length, canine cholecystokinin 1 (CCK1) receptor was cloned from gallbladder tissue using RT-PCR with a combination of primers designed to interact with conserved regions of the human and rat CCK1 receptor, which also shared ..
  39. ncbi The nicotinic acetylcholine receptor antagonist mecamylamine prevents escalation of cocaine self-administration in rats with extended daily access
    Stephen T Hansen
    Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 194:53-61. 2007
    ..Nicotine and cocaine are commonly coabused drugs in humans and recent work in animals suggests that activation of nicotinic acetylcholine receptors (nAChR) can increase cocaine self-administration...
  40. ncbi [Study on mec gene in methicillin-resistant staphylococci]
    T Yokoyama
    First Department of Internal Medicine, Kurume University School of Medicine
    Kansenshogaku Zasshi 67:1203-10. 1993
    ..In 28 strains of MSSA and two strains of methicillin with MIC of 6.25 micrograms/ml, all of the mec genes (mecA, mecR1 and mecI) were not detected...
  41. pmc Introduction of the mec element (methicillin resistance) into Staphylococcus aureus alters in vitro functional activities of fibrinogen and fibronectin adhesins
    P E Vaudaux
    Division of Infectious Diseases, University Hospital, Geneva, Switzerland
    Antimicrob Agents Chemother 42:564-70. 1998
    ..To evaluate the impact of methicillin resistance (mec) determinants on bacterial adhesion mediated by fibrinogen or fibronectin adhesins, we compared the in vitro ..
  42. ncbi Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases
    Z W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Mod Pathol 13:802-7. 2000
    ..Two types of tumors have been described under this category: mucoepidermoid carcinoma (MEC) and sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE)...
  43. pmc 5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence
    B Zhu
    Friedrich Miescher Institut, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nucleic Acids Res 28:4157-65. 2000
    ..The recombinant proteins from human and chicken have G/T mismatch as well as 5-methylcytosine (5-MeC) DNA glycosylase activities...
  44. pmc Expression of mucosal chemokines TECK/CCL25 and MEC/CCL28 during fetal development of the ovine mucosal immune system
    Francois Meurens
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Immunology 120:544-55. 2007
    CCL25/TECK and CCL28/MEC are CC chemokines primarily expressed in thymic dendritic cells and mucosal epithelial cells. The cognate receptors of CCL25 and CCL28, CCR9 and CCR10, respectively, are mainly expressed on T and B lymphocytes...
  45. pmc Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex
    P J West
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA
    Neuroscience 146:1000-12. 2007
    ..studies have revealed the presence of kainate receptor (KAR) mRNA in neurons of the rat medial entorhinal cortex (mEC), the functional presence and roles of these receptors are only beginning to be examined...
  46. pmc Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract obstruction
    T D Barrett
    Johnson and Johnson Pharmaceutical Research and Development, L L C, San Diego, CA, USA
    Br J Pharmacol 153:1650-8. 2008
    ..However, it is not clear to what extent this occurs in the early stages of pancreatitis induced by biliary tract obstruction in the rat and whether CCK initiates an inflammatory cascade in this condition...
  47. doi Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland
    Nazmiye Dincer
    Hacettepe University, Faculty of Medicine, Department of Pathology, Ankara, Turkey
    Oral Oncol 46:195-9. 2010
    Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) are salivary gland neoplasms with divergent morphological features and clinical behavior. ACC is a basaloid tumor whereas MEC is a glandular epithelial neoplasm...
  48. doi Analysis of Staphylococcal cassette chromosome mec in Staphylococcus haemolyticus and Staphylococcus sciuri: identification of a novel ccr gene complex with a newly identified ccrA allotype (ccrA7)
    Noriko Urushibara
    Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan
    Microb Drug Resist 17:291-7. 2011
    ..chromosome of the mecA gene, which is located on a mobile genetic element called staphylococcal cassette chromosome mec (SCCmec)...
  49. ncbi COMPARISON OF DIFFERENT PHENOTYPIC METHODS OF DETECTION OF METHICILLIN RESISTANCE IN Staphylococcus aureus WITH THE MOLECULAR DETECTION OF mec-A GENE
    Mohammad Zeeshan
    Department of Pathology and Microbiology, The Aga Khan University Hospital, Karachi, Pakistan
    J Coll Physicians Surg Pak 17:666-70. 2007
    ..agar screening plate (6microg/ml ) for early and accurate identification of MRSA by comparing with the detection of mec-A gene in our clinical isolates. Design: A comparative study...
  50. doi Evaluation of the role of three candidate human kinases in the conversion of the hepatitis C virus inhibitor 2'-C-methyl-cytidine to its 5'-monophosphate metabolite
    Nina L Golitsina
    Idenix Pharmaceuticals, Inc, 60 Hampshire Street, Cambridge, MA 02139, USA
    Antiviral Res 85:470-81. 2010
    ..One such molecule, 2'-C-methyl-cytidine (2'-MeC), entered clinical development as NM283, a valine ester prodrug form of 2'-MeC possessing improved oral ..
  51. ncbi Synthesis and structure of intermediates in copper-catalyzed alkylation of diphenylphosphine
    Matthew F Cain
    Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, USA
    Inorg Chem 49:7650-62. 2010
    ..Treatment of [Cu(NCMe)(4)][PF(6)] (1) with chelating ligands gave [CuL(NCMe)][PF(6)] (2; L = MeC(CH(2)PPh(2))(3) (triphos), 3; L = 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (XantPhos))...
  52. ncbi Normal ultrasonic evaluation of amniotic fluid in low-risk patients at term
    Thomas D Myles
    Department of Obstetrics and Gynecology, Texas Tech Health Sciences Center, 1400 Wallace Boulevard, Amarillo, TX 79106, USA
    J Reprod Med 47:621-4. 2002
    ....
  53. ncbi Cholecystokinin (CCK) stimulates aldosterone secretion from human adrenocortical cells via CCK2 receptors coupled to the adenylate cyclase/protein kinase A signaling cascade
    G Mazzocchi
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
    J Clin Endocrinol Metab 89:1277-84. 2004
    Cholecystokinin (CCK) IS a regulatory peptide that acts via two receptor subtypes, CCK1-R and CCK2-R...
  54. ncbi Expression of caveolin-1 in mucoepidermoid carcinoma of the salivary glands: correlation with vascular endothelial growth factor, microvessel density, and clinical outcome
    Lu Shi
    Key Laboratory for Oral Biomedical Engineering, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, People s Republic of China
    Cancer 109:1523-31. 2007
    ..The clinicopathologic significance of caveolin-1 expression and its correlation with angiogenesis remains unknown in mucoepidermoid carcinoma (MEC) of the salivary glands.
  55. ncbi 3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a novel, potent, and selective cholecystokinin 1 receptor antagonist: in vitro and in vivo pharmacological comparison with dexloxiglumide
    Magda F Morton
    Johnson and Johnson Pharmaceutical Research and Development L L C, San Diego, California 92121, USA
    J Pharmacol Exp Ther 323:562-9. 2007
    ..96 +/- 0.11), rat (pK(I) = 8.02 +/- 0.11), and canine (pK(I) = 7.98 +/- 0.04) CCK1 receptors, and it was also highly selective for the CCK1 receptor compared with the CCK2 receptor across the same ..
  56. pmc Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy
    Kazuhiro Ohmi
    Department of Biological Chemistry, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 106:8332-7. 2009
    ..vacuolation of lysosomal storage of undegraded substrate, but neurons in the medial entorhinal cortex (MEC) display accumulation of several additional substances...
  57. doi Typing of staphylococcal cassette chromosome mec encoding methicillin resistance in Staphylococcus aureus strains isolated at the bone marrow transplant centre of Tunisia
    O Bouchami
    Centre National de Greffe de Moelle Osseuse, Laboratory Service, Tunis, Tunisia
    Curr Microbiol 59:380-5. 2009
    Staphylococcal Cassette Chromosome mec (SCCmec) is a mobile genetic element that carries the gene mecA mediating the methicillin resistance in staphylococci. It is composed of mec and ccr gene complexes...
  58. ncbi CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells
    Kunio Hieshima
    Department of Microbiology, Kinki University School of Medicine, Osaka, Japan
    J Immunol 173:3668-75. 2004
    CCL25 (also known as thymus-expressed chemokine) and CCL28 (also known as mucosae-associated epithelial chemokine) play important roles in mucosal immunity by recruiting IgA Ab-secreting cells (ASCs) into mucosal lamina propria...
  59. pmc Measuring topology of low-intensity DNA methylation sites for high-throughput assessment of epigenetic drug-induced effects in cancer cells
    Arkadiusz Gertych
    Translational Cytomics Group, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Exp Cell Res 316:3150-60. 2010
    ..The cells were studied by immunofluorescence with a specific antibody against 5-methylcytosine (MeC), and 4,6-diamidino-2-phenylindole (DAPI) for delineation of methylated sites and global DNA in nuclei...
  60. ncbi FemA, a host-mediated factor essential for methicillin resistance in Staphylococcus aureus: molecular cloning and characterization
    B Berger-Bachi
    Institute of Medical Microbiology, University of Zurich, Switzerland
    Mol Gen Genet 219:263-9. 1989
    The methicillin resistance determinant (mec) in Staphylococcus aureus resides on additional DNA not present in isogenic sensitive cells...
  61. doi Effect of continuous milking and prostaglandin E2 on milk production and mammary epithelial cell turnover, ultrastructure, and gene expression
    E L Annen
    Department of Animal Sciences, University of Arizona, Tucson 85721, USA
    J Anim Sci 86:1132-44. 2008
    Mammary epithelial cell (MEC) growth is reduced in continuously milked (CM) mammary glands, and administration of a mammogenic compound such as prostaglandin E(2) (PGE(2)) at parturition might improve MEC growth in CM tissue...
  62. ncbi Insulin-Like growth factor I (IGF-I) and cyclic adenosine 3',5'-monophosphate regulate IGF-binding protein-3 gene expression by transcriptional and posttranscriptional mechanisms in mammary epithelial cells
    W S Cohick
    Department of Animal Sciences, Rutgers, State University of New Jersey, New Brunswick 08901, USA
    Endocrinology 141:4583-91. 2000
    Insulin-like growth factor I (IGF-I) is a potent mitogen for both normal and transformed mammary epithelial cells (MEC), and IGF-binding protein-3 (IGFBP-3) potentiates IGF-I action in these cells...
  63. ncbi Hydrogen production in a single chamber microbial electrolysis cell lacking a membrane
    Douglas Call
    Department of Civil and Environmental Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Environ Sci Technol 42:3401-6. 2008
    ..It has been assumed that a membrane is needed in an MEC to avoid hydrogen losses due to bacterial consumption of the product gas...
  64. doi Hydrogen and methane production from swine wastewater using microbial electrolysis cells
    Rachel C Wagner
    Department of Civil and Environmental Engineering, The Pennsylvania State University, 212 Sackett Building, University Park, PA 16802, USA
    Water Res 43:1480-8. 2009
    ..Hydrogen can theoretically be produced from wastewater by electrohydrogenesis in a microbial electrolysis cell (MEC) or by fermentation. Using a single-chamber MEC with a graphite-fiber brush anode, hydrogen gas was generated at 0...
  65. ncbi Epithelial sodium channel related to proteins involved in neurodegeneration
    C M Canessa
    Institut de Pharmacologie et de Toxicologie de l Université, Lausanne, Switzerland
    Nature 361:467-70. 1993
    ..The gene encoding this rat sodium channel subunit shares significant sequence similarity with mec-4 and deg-1, members of a family of Caenorhabditis elegans genes involved in sensory touch transduction and, when ..
  66. ncbi Sequence and properties of mecA, a negative regulator of genetic competence in Bacillus subtilis
    L Kong
    Public Health Research Institute, New York, New York 10016
    Mol Microbiol 9:365-73. 1993
    ..In complex media competence development is poor, and there is little or no expression of late competence genes. mec mutations permit competence development and late competence gene expression in complex media, and bypass the ..
  67. ncbi Measurements and model of the cat middle ear: evidence of tympanic membrane acoustic delay
    S Puria
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    J Acoust Soc Am 104:3463-81. 1998
    ..near the tympanic membrane is studied for three anesthetized cat ears after widely opening the ME cavities (MEC). Three conditions were measured: intact ossicles, drained cochlea, and disarticulated stapes...
  68. pmc Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus
    T Ito
    Department of Bacteriology, Juntendo University, Tokyo 113 8421, Japan
    Antimicrob Agents Chemother 45:1323-36. 2001
    ..Staphylococcus aureus is carried by a novel mobile genetic element, designated staphylococcal cassette chromosome mec (SCCmec), identified in the chromosome of a Japanese methicillin-resistant S. aureus (MRSA) strain...
  69. ncbi The emergence and evolution of methicillin-resistant Staphylococcus aureus
    K Hiramatsu
    Department of Bacteriology, Juntendo University, 2 1 1 Hongo Bunkyo ku, Tokyo 113 8421, Japan
    Trends Microbiol 9:486-93. 2001
    ..Integration of a staphylococcal cassette chromosome mec (SCCmec) element into the chromosome converts drug-sensitive S...
  70. ncbi The evolution of pandemic clones of methicillin-resistant Staphylococcus aureus: identification of two ancestral genetic backgrounds and the associated mec elements
    D C Oliveira
    Laboratory of Microbiology, The Rockefeller University, New York, NY 10021, USA
    Microb Drug Resist 7:349-61. 2001
    ..The data allow tentative identification of an evolutionary pathway for the emergence of pandemic MRSA clones and also provide evidence for the multiple, yet restricted, numbers of acquisition of the mec element by S. aureus.
  71. ncbi Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor
    Craig Giragossian
    Department of Chemistry, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biochemistry 41:4560-6. 2002
    ..results, with CCK-8 in close proximity to TM7, differ from previous structural studies of CCK-8 association with CCK1-R, in which the ligand formed a number of interactions with TM6...
  72. ncbi Cyclic tetramers composed of rhodium(III), iridium(III), or ruthenium(II) half-sandwich and 6-purinethiones
    Kazuaki Yamanari
    Department of Chemistry, Graduate School of Science, Osaka University, 1 16 Machikaneyama cho, Toyonaka, Osaka 560 0043, Japan
    Inorg Chem 41:6824-30. 2002
    ..complexes [[M(Cp*)(L)](4)](4+) and [[Ru(II)(L)(cymene)](4)](4+) [Cp* = eta(5)-C(5)Me(5), cymene = eta(6)-p-MeC(6)H(4)Pr(i); M = Rh(III) and Ir(III); HL = 6-purinethione (H(2)put) and 2-amino-6-purinethione (H(2)aput)] were ..
  73. ncbi A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, 1441 Eastlake Ave, Rm 4441, Los Angeles, CA 90089 9175, USA
    Hum Mol Genet 12:2679-92. 2003
    ..gene among African-American, Hawaiian, Japanese, Latina and White women in the Multiethnic Cohort Study (MEC). We utilized 74 densely spaced single-nucleotide polymorphisms (SNPs) (one every approximately 2...
  74. ncbi Hospital transmission of community-acquired methicillin-resistant Staphylococcus aureus among postpartum women
    Lisa Saiman
    Department of Pediatrics, Columbia University, New York, New York 10032, USA
    Clin Infect Dis 37:1313-9. 2003
    ..All were spa type 131, all contained the staphylococcal chromosomal cassette mec type IV, and all expressed Panton-Valentine leukocidin and staphylococcal enterotoxins C and H...
  75. ncbi The effect of modified eros centre, outdoor raising or conventional group housing on breeding gilts and its effects on reproductive performance over four parities
    P Cede
    Swine Ethology Studio, Raubbühlstrasse 4, CH 8600 Dubendorf, Switzerland
    Theriogenology 61:185-94. 2004
    ..The objective of the study was to determine if an indoor modified eros centre (MEC) compared to indoor or outdoor group housing of gilts, influenced the onset of puberty of gilts and the ..
  76. pmc Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle
    T Goldammer
    Molecular Biology Research Division, Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Clin Diagn Lab Immunol 11:174-85. 2004
    ..In situ hybridizations revealed that BNBD5 is expressed predominantly in the mammary epithelial cells (MEC) of the infected gland...
  77. pmc Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway
    Vladimir A Shamanin
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 24:2144-52. 2004
    ..We analyzed the functionality of the p14(ARF)-p53 pathway in human mammary epithelial cells (MEC) immortalized by human papillomavirus 16 (HPV16) E6, the p53 degradation-defective E6 mutant Y54D, or hTERT...
  78. ncbi Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes
    John S Francis
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Clin Infect Dis 40:100-7. 2005
    ..aureus (MRSA) carrying Panton-Valentine leukocidin (PVL) genes and the staphylococcal cassette chromosome mec (SCCmec) type IV indicate that MRSA infections are evolving into a community-related problem...
  79. ncbi An enteric signal regulates putative gastrointestinal presympathetic vasomotor neurons in rats
    Daniela M Sartor
    Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    Am J Physiol Regul Integr Comp Physiol 290:R625-33. 2006
    ..Alternatively, animals were pretreated with the CCK1 receptor antagonists devazepide and lorglumide or the 5-HT3 antagonist MDL-72222 before SO-SBTI administration...
  80. ncbi Elevated plasma corticotrophin release factor levels and in utero meconium passage
    Jayaraman Lakshmanan
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Pediatr Res 61:176-9. 2007
    Intrauterine meconium (MEC) passage and aspiration may result in significant newborn morbidity, though there is little understanding of the physiologic mechanisms for MEC passage...
  81. ncbi SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists
    Laurent Gomez
    Johnson and Johnson Pharmaceutical Research and Development L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 17:6493-8. 2007
    ..The difference in affinity between the two enantiomers for the CCK(1) receptor and the flexible nature of the linker led to the design of constrained analogs with increased potency...
  82. doi Oral ondansetron is highly active as rescue antiemetic treatment for moderately emetogenic chemotherapy: results of a randomized phase II study
    Alessandra Fabi
    Department of Medical Oncology, Regina Elena Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy
    Support Care Cancer 16:1375-80. 2008
    In the present phase II randomized study, two different schedules of ondansetron were investigated as rescue antiemetic treatment for delayed emesis related to moderately emetogenic chemotherapy (MEC).
  83. pmc Molecular epidemiology of methicillin-resistant Staphylococcus aureus bloodstream isolates in urban Detroit
    Thea Chua
    Henry Ford Health System, Wayne State University School of Medicine, Detroit, Michigan 48202, USA
    J Clin Microbiol 46:2345-52. 2008
    ..Forty-nine percent of the isolates had staphylococcal cassette chromosome mec II, and 56% had agr II. All USA300 isolates were positive for the Panton-Valentine leukocidin toxin genes and agr I...
  84. doi High levels of expression of cytokeratin 5 are strongly correlated with poor survival in higher grades of mucoepidermoid carcinoma
    N E Lueck
    Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 1009, USA
    J Clin Pathol 61:837-40. 2008
    Mucoepidermoid carcinoma (MEC) is the most common malignant primary salivary gland tumour. Little is known about cytokeratin expression in MEC or how it may relate to survival...
  85. doi Evaluation of catalysts and membranes for high yield biohydrogen production via electrohydrogenesis in microbial electrolysis cells (MECs)
    Shaoan Cheng
    Department of Civil and Environmental Engineering, Hydrogen Energy Center, Penn State University, University Park, PA 16802, USA
    Water Sci Technol 58:853-7. 2008
    ..In many MEC reactors, precious metal catalysts and expensive cation exchange membranes are often used...
  86. doi Biodegradation of mixed pesticides by mixed pesticide enriched cultures
    K Rama Krishna
    Department of Civil Engineering, Indian Institute of Technology Madras, Chennai, India
    J Environ Sci Health B 44:18-30. 2009
    ..kinetics of mixed (lindane, methyl parathion and carbofuran) pesticides by mixed pesticide enriched cultures (MEC) under various environmental conditions...
  87. pmc Vancomycin MIC plus heteroresistance and outcome of methicillin-resistant Staphylococcus aureus bacteremia: trends over 11 years
    Adina C Musta
    Department of Medicine, Infectious Diseases, St John Hospital and Medical Center, Detroit, MI, USA
    J Clin Microbiol 47:1640-4. 2009
    ..Staphylococcal chromosome cassette mec (SCCmec) typing of 261 isolates (including all hVISA isolates) revealed that 93...
  88. pmc Automated quantification of DNA demethylation effects in cells via 3D mapping of nuclear signatures and population homogeneity assessment
    Arkadiusz Gertych
    Minimally Invasive Surgical Technologies Institute, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cytometry A 75:569-83. 2009
    ..and untreated populations, were studied by immunofluorescence with a specific antibody against 5-methylcytosine (MeC), and 4,6-diamidino-2-phenylindole (DAPI) for delineation of methylated sites and global DNA in nuclei (n = 163)...
  89. doi The efficacy of oral ondansetron and dexamethasone for the prevention of acute chemotherapy-induced nausea and vomiting associated with moderately emetogenic chemotherapy - a retrospective audit
    W L Ng
    Department of Medical Oncology, Macarthur Cancer Therapy Centre, Sydney, NSW, Australia
    Eur J Cancer Care (Engl) 19:403-7. 2010
    ..of acute chemotherapy-induced nausea and vomiting (CINV) resulting from moderately emetogenic chemotherapy (MEC) is unknown...
  90. doi Evaluation of the Etest method for susceptibility testing of Aspergillus spp. and Fusarium spp. to three echinocandins
    A I Martos
    Microbiology Service, University Hospital of Valme, Seville Cádiz Road, Seville, Spain
    Med Mycol 48:858-61. 2010
    ..4-100%) except for A. niger and A. glaucus at 24 h of incubation. Micafungin and anidulafungin MEC and MIC results were lower than those of caspofungin (< or =0...
  91. doi Pre-acclimation of a wastewater inoculum to cellulose in an aqueous-cathode MEC improves power generation in air-cathode MFCs
    Shaoan Cheng
    State Key Laboratory of Clean Energy Utilization, Department of Energy Engineering Zhejiang University, Hangzhou 310027, PR China
    Bioresour Technol 102:367-71. 2011
    ..be achieved in air-cathode MFCs using an inoculum from a two-chamber, aqueous-cathode microbial electrolysis cell (MEC)...
  92. pmc Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area
    Patrick Basset
    Service of Hospital Preventive Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 54:4589-95. 2010
    Recent population genetic studies suggest that staphylococcal cassette chromosome mec (SCCmec) was acquired much more frequently than previously thought...
  93. pmc Fusidic acid resistance determinants in Staphylococcus aureus clinical isolates
    Hsiao Jan Chen
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, 1 Chang Te Street, Taipei 100, Taiwan
    Antimicrob Agents Chemother 54:4985-91. 2010
    ..On the basis of spa and staphylococcal cassette chromosome mec element (SCCmec) typing, two major genotypes, spa type t037-SCCmec type III (t037-III; 28/45; 62%) and t002-II (13/..
  94. doi Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells
    Yanmei Liang
    Section of Infectious Disease, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, MA 02118, USA
    Clin Immunol 138:33-40. 2011
    ..induce CCR9 and CCR10 expression by circulating B cells and increased chemotaxis to cognate chemokines CCL25 and CCL28 suggesting that TLR2 induces B cell homing to the gastrointestinal tract...
  95. pmc Panton-valentine leukocidin-positive and toxic shock syndrome toxin 1-positive methicillin-resistant Staphylococcus aureus: a French multicenter prospective study in 2008
    Jerome Robert
    Bactériologie Hygiène, UFR de Médecine Pierre et Marie Curie, Site Pitié Salpêtrière, 91 Bd de l Hopital, 75634 Paris Cedex 13, France
    Antimicrob Agents Chemother 55:1734-9. 2011
    ..French laboratories were characterized using agr alleles, spa typing, and the staphylococcal cassette chromosome mec element and PCR profiling of 21 toxin genes...
  96. pmc Hemostatic and toxinological diversities in venom of Micrurus tener tener, Micrurus fulvius fulvius and Micrurus isozonus coral snakes
    Ana M Salazar
    Laboratorio de Fisiopatologia, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 20632, Caracas 1020A, Venezuela
    Toxicon 58:35-45. 2011
    ..neurotoxins and phospholipase A₂s, this study demonstrated, by SDS-PAGE and molecular exclusion chromatography (MEC), that these venoms also contain high-molecular-weight proteins between 50 and 150 kDa that target the hemostatic ..
  97. doi Quantification of chemokine and chemokine receptor gene expression in duodenal mucosa of dogs with inflammatory bowel disease
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 144:290-8. 2011
    ..alpha (MIP-3α)/CCL20, thymus-expressed chemokine (TECK)/CCL25, mucosae-associated epithelial chemokine (MEC)/CCL28 and IL-8/CXCL8 mRNA in IBD dogs were significantly higher than the corresponding levels in control dogs, but there ..
  98. pmc DNA methylation patterns of Brachypodium distachyon chromosomes and their alteration by 5-azacytidine treatment
    Natalia Borowska
    Department of Plant Anatomy and Cytology, University of Silesia, Jagiellonska 28, 40 032, Katowice, Poland
    Chromosome Res 19:955-67. 2011
    Sequential immunolocalisation of 5-methylcytosine (5-MeC) and fluorescence in situ hybridisation with chromosome-specific BAC clones were performed on Brachypodium distachyon mitotic metaphase chromosomes to determine specific DNA ..
  99. doi Adding microencapsulated pear ester to insecticides for control of Cydia pomonella (Lepidoptera: Tortricidae) in apple
    Alan L Knight
    Yakima Agricultural Research Laboratory, Agricultural Research Service, USDA, Wapato, WA 98951, USA
    Pest Manag Sci 69:66-74. 2013
    ..by the addition of a microencapsulated formulation of pear ester, ethyl (2E, 4Z)-2,4-decadienoate (PE-MEC, 5% AI), was evaluated in field trials in apple from 2005 to 2009.
  100. pmc The F-box protein MEC-15 (FBXW9) promotes synaptic transmission in GABAergic motor neurons in C. elegans
    Yu Sun
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e59132. 2013
    ..Here, we investigated the function of the F-box protein MEC-15 (FBXW9), one of a small number of F-box proteins evolutionarily conserved from C. elegans to mammals...
  101. pmc Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis
    Nicholas J Hargus
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908 0710, USA
    J Neurophysiol 110:1144-57. 2013
    ..We sought to investigate whether medial entorhinal cortex (mEC) layer II neurons become hyperexcitable and display proexcitatory behavior of Na channels during epileptogenesis...

Research Grants64

  1. Defining the bacterial factors that modulate sensitivity to B-lactam in CA-MRSA
    AMBROSE LIN YAU CHEUNG; Fiscal Year: 2010
    ..There are five types of SCCmec in MRSA, which differ with respect to the mec complex (mecI-mecR1-mecA), integrated plasmids, transposons, IS elements and other accessory genes...
  2. METHICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUS
    Henry Chambers; Fiscal Year: 1993
    ..PBP 2a is encoded by the mec determinant, for which no equivalent allele exists in susceptible strains...
  3. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    Gordon Archer; Fiscal Year: 2003
    ..in resistant isolates, is common to all resistant staphylococcal species and is accompanied by >30 kb of DNA (mec DNA) that is also unique to resistant isolates...
  4. Epidemiology of Putative Causal Variants in the Multiethnic Cohort
    Loic Le Marchand; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): In response to RFA-HG-07-014, we propose to use the Multiethnic Cohort (MEC) study to characterize the "epidemiologic architecture" of putative causal variants identified in large-scale genomic ..
  5. Functional Characterization of CXCL14, CXCL17, and CCL28; three mucosal chemokine
    Albert Zlotnik; Fiscal Year: 2010
    ..We have used gene array analyses to identify three chemokines (CXCL14, CXCL17 and CCL28) that exhibit very high expression in human mucosal tissues...
  6. Sequence Distribution of Tobacco Carcinogen-DNA Adducts
    Natalia Y Tretyakova; Fiscal Year: 2012
    ..controls gene expression by mediating the binding of specific proteins (methyl-CpG binding proteins) to MeCG sites (MeC = 5-methylcytosine) and the recruitment of histone-modifying enzymes that promote chromatin remodeling...
  7. Mechanisms of Degenerative Cell Death in C. elegans
    MONICA A DRISCOLL; Fiscal Year: 2013
    ..Our genetic dissection of this process in nematodes suggests that Ca+2 influx through the MEC DEG/ENaC channel is critical in necrosis initiation, and that the neurotoxicity mechanism requires ER Ca+2 release...
  8. Jane C Figueiredo; Fiscal Year: 2015
    ..upon existing NIH-funded resources, the Colon Cancer Family Registry (Colon CFR) and the Multiethnic Cohort Study (MEC)...
  9. Chemosensing in the Gastrointestinal Tract
    Catia Sternini; Fiscal Year: 2010
    ..of neuronal activity, and the role of CCK and PYY, peptides that affect GI function and feeding behavior, acting at CCK1 and Y2 receptors on vagal afferents, 1b) the effects of T2R agonists on vagal pathways using electrophysiological ..
  10. Multiethnic Cohort Study of Diet and Cancer
    Laurence N Kolonel; Fiscal Year: 2012
    The Multiethnic Cohort (MEC) Study was designed to prospectively investigate the relationship of diet and other lifestyle factors to cancer risk in five ethnic groups (African Americans, Japanese Americans, Latinos, Native Hawaiians and ..
  11. IONA C CHENG; Fiscal Year: 2014
    ..cases, 2,863 controls) and prostate cancer (3,634 cases, 3,713 controls) nested within the Multiethnic Cohort (MEC)...
  12. Albert Zlotnik; Fiscal Year: 2016
    ..We have identified three chemokines (CXCL14, CXCL17 and CCL28) as the most highly expressed in mucosal tissues...
  13. Chuan He; Fiscal Year: 2016
    ..DNA/RNA base damage repair enzyme that catalyzes direct reversal of N1-methyladenine (1-meA), N3-methylcytosine (3-meC), and exocyclic DNA base lesions. Nine sequence homologues have been identified in the human genome...
  14. Julie R Palmer; Fiscal Year: 2015
    ..Black Women's Health Study (BWHS), the Women's Circle of Health Study (WCHS) and the Multi-ethnic Cohort (MEC) and continue to accrue cases for a final sample size of more than 5500 cases and 5500 controls...
  15. Valerie Marie Weaver; Fiscal Year: 2014
    ..to have altered collagen structures to interrogate whether collagen cross-linking and stiffness influence MEC motility and invasion by enhancing PI3 kinase signaling to promote chemotaxis and durotaxis...
  16. REBECCA SARA COOK; Fiscal Year: 2014
    ..We will use mice harboring MEC-specific loss of ErbB3 to examine mammary glands at each stage of post-natal mammary gland development...
  17. John F DiPersio; Fiscal Year: 2015
    ..G-CSF+AMD3100 will be administered prior to mitoxantrone-etoposide-high dose Ara-C (MEC) salvage chemotherapy to optimally mobilize leukemic blasts, thus sensitizing the AML blasts to MEC chemotherapy...
  18. ENGINEERED GLUCOSE METABOLISM IN INSULIN SECRETING CELLS
    Christopher B Newgard; Fiscal Year: 2010
    ..the repolarization phase of the plasma membrane current;b) NADPH produced by the pyruvate cycling enzymes ICDc and MEc controls expression of neuroendocrine protein 7B2, a regulator of the proinsulin processing enzyme PC2, thereby ..
  19. Identification of transcriptional determinants of dendritic patterning
    David M Miller; Fiscal Year: 2010
    ..morphogenesis;(2) Use the mRNA tagging method to reveal genes downstream of the conserved LIM- homeodomain protein, MEC-3, an established determinant of PVD dendritic branching and;(3) Extend this mRNA tagging strategy to at least five ..
  20. Loic Le Marchand; Fiscal Year: 2016
    We propose to utilize the Multiethnic Cohort (MEC), a PAGE Phase 1 study, to sample and assess genomic variation in well-phenotyped individuals of non-European (EA) ancestry...
  21. Spread of Community-Acquired MRSA Among Household Contacts
    Robert S Daum; Fiscal Year: 2010
    ..susceptibility patterns in these CA-MRSA strains was characterized, now called "staphylococcal chromosomal cassette mec" type IV or SCCmec type IV, it was realized that a distinct phenomenon had occurred not involving spread of HA-MRSA ..
  22. Functional Adaptation of Microtubules by Acetylation
    Jacek Gaertig; Fiscal Year: 2013
    ..This protein is an ortholog of MEC-17, a previously studied protein which is required for the function of touch receptor neurons in C. elegans...
  23. Food intake and energy metabolism regulated by apo AIV and CCK
    Chunmin C Lo; Fiscal Year: 2013
    ..ip) administration of combined apo AIV and CCK additively reduces meal size and this interaction activates the CCK1 receptor (CCK1R)...
  24. Mechanisms for HIV-1 Persistence in Human Mammary Tissue and Breast Milk Cells
    Stephanie M Dorosko; Fiscal Year: 2012
    ..HIV-1 viral reservoir in the breast compartment, we will test the hypotheses that (1) mammary epithelial cells (MEC) are susceptible to infection with HIV-1 and/or can initiate a productive infection in susceptible CD4+ lymphocytes ..
  25. Targeting Leukemia Stromal Interactions in AML
    Geoffrey L Uy; Fiscal Year: 2013
    ..a clinical trial entitled, "A phase l/ll study of AMD3100 plus mitoxantrone, etoposide, and cytarabine (AMD3100-I-MEC) in relapsed or refractory AML...
  26. Ivan Soltesz; Fiscal Year: 2015
    ..There is substantial evidence from both humans and animal models indicating that the medial entorhinal cortex (MEC) plays critical roles in the generation and maintenance of TLE...
  27. Age effects on grid cell and scene recognition systems of entorhinal cortex
    JAMES PERCY LISTER; Fiscal Year: 2011
    ..The medial entorhinal cortex (MEC) appears to process information about self-motion and position while the lateral entorhinal cortex (LEC) processes ..
  28. Ronen Marmorstein; Fiscal Year: 2016
    ..In this proposal we will study the Rtt109 HAT, the NATA N-amino protein acetyltransferase and the aTAT1/MEC-17 tubulin acetyltransferase as model systems to answer these mechanistic questions that will have important ..
  29. Martin Chalfie; Fiscal Year: 2016
    ..basis of cell-type specification within the TRNs;3) to characterize lipid- binding and modulating components of the MEC-4 channel complex and similar proteins;and 4) to investigate the role of the extracellular matrix (ECM) in touch ..
  30. Sergey V Ivanov; Fiscal Year: 2014
    ..17 of 18, or ~94%) express high levels of the neurotrophin receptor tyrosine kinase TrkC, whereas mucoepidermoid (MEC) and head and neck squamous cell carcinomas (HNSCC) are TrkC-negative...
  31. Transcriptional Role of BRCA1 in Breast Cancer
    Wen Hwa Lee; Fiscal Year: 2012
    ..ZBRK1 by RNAi in mammary epithelial cells (MECs) 3-D culture, a close mimicry of an in vivo environment, leads to MEC proliferation and impairs mammary acinus differentiation by altering the expression of genes including ANG1 (..
  32. David M Miller; Fiscal Year: 2016
    ..powerful cell-specific profiling methods to identify targets of a conserved LIM-homeodomain transcription factor, MEC-3, that is required for PVD branching...
  33. Endothelial protease activity, organogenesis and birth defects
    Suneel S Apte; Fiscal Year: 2012
    ..Microvascular endothelial cells (mEC), which line capillaries, have a well-known function in regulation of angiogenesis, but less is known about their ..
  34. Manoj K Patel; Fiscal Year: 2016
    ..Our proposal will focus on medial entorhinal cortex (mEC) and subiculum neurons using an animal model of temporal lobe epilepsy (TLE), a common form of adult pharmaco-..
  35. Genes, Hormones and Breast Cancer Risk
    Veronica Wendy Setiawan; Fiscal Year: 2010
    ..A cross-sectional study of healthy postmenopausal women from the Multiethnic Cohort Study (MEC) will be conducted to 1) determine whether known/potential breast cancer risk factors are associated with plasma ..
  36. Whole Genome Scan for Modifier Genes in Colorectal Cancer
    Loic Le Marchand; Fiscal Year: 2012
    ..lifestyle exposure information and clinical data for five racial-ethnic groups in the Multiethnic Cohort study (MEC), as well as for Japanese in Japan in the Japan Public Health Center cohort study (JPHC)...
  37. Robert P Hausinger; Fiscal Year: 2014
    ..Finally, biochemical and spectroscopic properties will be elucidated for TET1, a 5-meC hydroxylase that might function with another enzyme as a DNA demethylase...
  38. Miriam B Goodman; Fiscal Year: 2016
    ..cell membrane function, 2) disrupt the microtubule and spectrin cytoskeleton and 3) disrupt selected domains in the MEC-4 proteins crucial to the formation of the sodium-selective native MeT channels,...
  39. James J Knierim; Fiscal Year: 2015
    ..knowledge of the properties of the two major cortical inputs to the hippocampus, the medial entorhinal cortex (MEC) and the lateral entorhinal cortex (LEC)...
  40. Characterizing the Role of MYC-MAX Complexes in TORC1/MAML2-mediated Oncogenesis
    ANTONIO LUIGI AMELIO; Fiscal Year: 2010
    ..Mucoepidermoid carcinomas (MEC) and Warthin's tumors are salivary gland tumors that share a common t(11;19)(q21;p13.1) translocation...
  41. Diane J Mathis; Fiscal Year: 2015
    ..Its Specific Aims are: 1. To compare the repertoires of Aire-dependent MEC transcripts from adult and perinatal mice;2...
  42. Influence of extracellular matrix on the assembly of mechanosensory complexes
    Brian Coblitz; Fiscal Year: 2010
    ..C. elegans gentle touch is transduced by the Na+permeable MEC-4 ion channel complex, which is localized in a punctate pattern along the processes of touch neurons...
  43. David W Tank; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The medial entorhinal cortex (MEC) contributes to navigation and episodic memory, essential cognitive functions degraded in many degenerative and psychiatric disorders...
  44. Characterizing Genetic Susceptibility to Breast and Prostate Cancer;the BPC3
    Elio Riboli; Fiscal Year: 2011
    ..Other genome-wide association studies are ongoing, including an admixture scan for prostate cancer in the MEC, a breast cancer scan using pooled DNAs in the Womens'Health Initiative (WHI), and a breast cancer scan at the ..
  45. Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3
    DAVID JOHN HUNTER; Fiscal Year: 2010
    ..Other genome-wide association studies are ongoing, including an admixture scan for prostate cancer in the MEC, a breast cancer scan using pooled DNAs in the Womens'Health Initiative (WHI), and a breast cancer scan at the ..
  46. Diane J Mathis; Fiscal Year: 2016
    ..these two aspects of aire's mode of action - specifically, we intend: i) to gauge the plasticity of the MEC PTT repertoire; ii) to generalize and localize the antigen-presentation defect exhibited by aire-null MECs; iii) to ..
  47. Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3
    Brian E Henderson; Fiscal Year: 2010
    ..Other genome-wide association studies are ongoing, including an admixture scan for prostate cancer in the MEC, a breast cancer scan using pooled DNAs in the Womens'Health Initiative (WHI), and a breast cancer scan at the ..
  48. MARK PAUL BRANDON; Fiscal Year: 2014
    ..The discovery of grid cells, neurons in the medial entorhinal cortex (MEC) that discharge in a multitude of locations that are positioned at the vertices of a tessellating triangular grid ..
  49. Lynne R Wilkens; Fiscal Year: 2014
    ..provided by applicant): This application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California between 1993 and 1996 to study risk factors for ..
  50. Loic Le Marchand; Fiscal Year: 2016
    ..Markedly different patterns of adiposity exist among the five ethnic/racial populations of the Multiethnic Cohort (MEC) Study (African Americans, Japanese Americans, Latinos, Native Hawaiians, whites)...
  51. Structure of Beta-lactam resistance regulators
    MARTIN SAFO; Fiscal Year: 2007
    ..The mec (MecRI and Mecl) and bla (BlaRl and Blal) regulators seem to have a signal transduction mechanism of action that is ..
  52. Sequence Distribution of Tabacco Carcinogen-DNA Adducts
    Natalia Tretyakova; Fiscal Year: 2007
    ..The presence of 5-methylcytosine (MeC) induces small, but noticeable changes in DMA structure and dynamics, leading to altered DNA-protein interactions ..
  53. Joseph R Reeve; Fiscal Year: 2014
    ..presented in this proposal will provide a decisive test of the hypothesis at risk: two locations of the CCK1 receptor control total daily food intake: the receptors at vagal afferents that regulate meal size and the ..
  54. The Medial Entorhinal Cortex and Temporal Lobe Epilepsy
    KAREN WILCOX; Fiscal Year: 2007
    ..The overall goal of this proposal is to determine the role of the medial entorhinal cortex (mEC) in the development of chronic epilepsy in the kainic acid model of TLE...
  55. NEUROMODULATION BY ZINC IN THE HIPPOCAMPAL REGION
    John White; Fiscal Year: 2000
    ..patch-clamp techniques, these kinetics will be measured in dissociated neurons from the medial entorhinal cortex (MEC). Hypothesis B...
  56. Single-Base Resolution Method of 5-hmC in Biology
    Shuang Chang; Fiscal Year: 2012
    ..Because current sequencing methods cannot differentiate 5-meC from 5-hmC, the immediate challenge is to develop robust methods to ascertain the positions of 5-hmC within the ..
  57. LASER PHOTORADIATION THERAPY OF MALIGNANT TUMORS
    Michael Berns; Fiscal Year: 2002
    ..of PDT action on tumor microvasculature at two levels: (1) Human dermal microvascular endothelial cells (MEC); and (2) tumor-induced capillary proliferation in the rabbit cornea...
  58. Qing Dai; Fiscal Year: 2016
    ..Because the sequencing methods currently available cannot differentiate 5-meC from 5-hmC, we recently developed a chemical-labeling strategy for 5-hmC sequencing through which we have ..
  59. METABOLISM OF 5-METHYLCHRYSENE BY FISH
    Nancy Shappell; Fiscal Year: 1993
    ..We propose to investigate the metabolism of 5-methylchrysene (5-MeC) as a model compound to study the metabolism of methylated PAHs by fish...
  60. RELATIONSHIPS BETWEEN PROSTANOIDS AND CELLULAR INJURY
    John Flynn; Fiscal Year: 2000
    ..Endothelial cells, especially those of the microcirculation (MEC), are a prime target for circulating bacterial lipopolysaccharide (LPS)...
  61. FUNCTION OF THE CALCIUM SENSING RECEPTOR IN THE BREAST
    John Wysolmerski; Fiscal Year: 2009
    ..Finally, given the loss of CaR expression during pregnancy, a time of intense MEC proliferation, we hypothesize that CaR signaling inhibits MEC proliferation and promotes MEC differentiation...
  62. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert I Glazer; Fiscal Year: 2010
    ..b>MEC and MCF-7 cell lines stably expressing either PPARJ or PDK1 or both genes will be used to study the synergy between ..
  63. Mammary Tumor Stem Cells
    Anne Peaston; Fiscal Year: 2009
    ..Parity-induced mammary epithelial cells (PI-MEC) are a self- renewing, pluripotent population, thus fulfilling the functions of mammary stem or progenitor cells...
  64. DEVELOPMENTAL GENETICS OF CAENORHABDITIS ELEGANS
    Robert Herman; Fiscal Year: 2004
    ..elegans mec-8 gene, which encodes a protein with two RNA recognition motifs and regulates the processing of transcripts of ..

Patents1

  1. Mammalian chemokines
    Patent Number: EP1418236-A1; Date:2004-05-12