CCL15

Summary

Gene Symbol: CCL15
Description: C-C motif chemokine ligand 15
Alias: HCC-2, HMRP-2B, LKN-1, LKN1, MIP-1 delta, MIP-1D, MIP-5, MRP-2B, NCC-3, NCC3, SCYA15, SCYL3, SY15, C-C motif chemokine 15, chemokine (C-C motif) ligand 15, chemokine CC-2, leukotactin 1, macrophage inflammatory protein 5, new CC chemokine 3, small inducible cytokine subfamily A (Cys-Cys), member 15, small-inducible cytokine A15
Species: human

Top Publications

  1. ncbi Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3
    B S Youn
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 159:5201-5. 1997
  2. pmc HCC-2, a human chemokine: gene structure, expression pattern, and biological activity
    A Pardigol
    Lower Saxony Institute for Peptide Research, D 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 95:6308-13. 1998
  3. ncbi Synthesis and characterization of the human CC chemokine HCC-2
    S E Escher
    Niedersächsisches Institut für Peptid Forschung, Hannover, Germany
    J Pept Res 54:505-13. 1999
  4. ncbi Hemofiltrate CC chemokines with unique biochemical properties: HCC-1/CCL14a and HCC-2/CCL15
    U Forssmann
    IPF PharmaCeuticals GmbH, Institute of the Medical School of Hanover, Section of Pharmacology, D 30625 Hanover, Germany
    J Leukoc Biol 70:357-66. 2001
  5. ncbi A novel chemokine, Leukotactin-1, induces chemotaxis, pro-atherogenic cytokines, and tissue factor expression in atherosclerosis
    Won Ha Lee
    Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 50 Ilwon Dong Kangnam Ku, Seoul 135 710, South Korea
    Atherosclerosis 161:255-60. 2002
  6. ncbi Functional analysis of chemically synthesized derivatives of the human CC chemokine CCL15/HCC-2, a high affinity CCR1 ligand
    S E Escher
    IPF PharmaCeuticals GmbH, Feodor Lynen Strasse 31, D 30625 Hannover, Germany
    J Pept Res 63:36-47. 2004
  7. ncbi Proteolytic activation of alternative CCR1 ligands in inflammation
    Robert D Berahovich
    ChemoCentryx, Mountain View, CA 94043, USA
    J Immunol 174:7341-51. 2005
  8. ncbi Quantum proteolytic activation of chemokine CCL15 by neutrophil granulocytes modulates mononuclear cell adhesiveness
    Rudolf Richter
    IPF PharmaCeuticals GmbH, Hannover, Germany
    J Immunol 175:1599-608. 2005
  9. doi A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa
    K Kotarsky
    Immunology Section, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Mucosal Immunol 3:40-8. 2010
  10. ncbi Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1
    S Zhang
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 162:4938-42. 1999

Detail Information

Publications135 found, 100 shown here

  1. ncbi Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3
    B S Youn
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 159:5201-5. 1997
    ..Hence, we have isolated and characterized a human C6 beta-chemokine that is a potent agonist at CCR1 and CCR3 and shows broad biologic activities, including leukocyte chemoattraction...
  2. pmc HCC-2, a human chemokine: gene structure, expression pattern, and biological activity
    A Pardigol
    Lower Saxony Institute for Peptide Research, D 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 95:6308-13. 1998
    ..It is a potent chemoattractant and inducer of enzyme release in monocytes and a moderately active attractant for eosinophils. Desensitization studies indicate that HCC-2 acts mainly via CC chemokine receptor CCR1...
  3. ncbi Synthesis and characterization of the human CC chemokine HCC-2
    S E Escher
    Niedersächsisches Institut für Peptid Forschung, Hannover, Germany
    J Pept Res 54:505-13. 1999
    ..HCC-2-(48-113) and the mutant [Ala64,104]HCC-2-(48-113) were further analyzed by CD and one-dimensional 1H NMR-spectroscopy. Both peptides adopt a similar stable secondary and tertiary structure in solution...
  4. ncbi Hemofiltrate CC chemokines with unique biochemical properties: HCC-1/CCL14a and HCC-2/CCL15
    U Forssmann
    IPF PharmaCeuticals GmbH, Institute of the Medical School of Hanover, Section of Pharmacology, D 30625 Hanover, Germany
    J Leukoc Biol 70:357-66. 2001
    The hemofiltrate CC chemokines CCL14a (formerly HCC-1), CCL14b (formerly HCC-3), and CCL15 (formerly HCC-2) are encoded by mono- as well as bicistronic transcripts from a tandem gene arrangement on human chromosome 17q11.2...
  5. ncbi A novel chemokine, Leukotactin-1, induces chemotaxis, pro-atherogenic cytokines, and tissue factor expression in atherosclerosis
    Won Ha Lee
    Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, 50 Ilwon Dong Kangnam Ku, Seoul 135 710, South Korea
    Atherosclerosis 161:255-60. 2002
    ..LKN-1 may chemoattract immune cells into the plaque, induce pro-inflammatory cytokines, and produce thrombi by inducing TF expression...
  6. ncbi Functional analysis of chemically synthesized derivatives of the human CC chemokine CCL15/HCC-2, a high affinity CCR1 ligand
    S E Escher
    IPF PharmaCeuticals GmbH, Feodor Lynen Strasse 31, D 30625 Hannover, Germany
    J Pept Res 63:36-47. 2004
    The CCL15 is a human CC chemokine that activates the receptors, CCR1 and CCR3. Unlike other chemokines, it contains an unusually long N-terminal domain of 31 amino acids preceding the first cysteine residue and a third disulfide bond...
  7. ncbi Proteolytic activation of alternative CCR1 ligands in inflammation
    Robert D Berahovich
    ChemoCentryx, Mountain View, CA 94043, USA
    J Immunol 174:7341-51. 2005
    ..Indeed, four such chemokines, CCL6/C10/MIP-related protein-1, CCL9/MIP-1gamma/MIP-related protein-2, CCL15/MIP-1delta/hemofiltrate CC chemokine-2/leukotactin-1, and CCL23/CKbeta8/myeloid progenitor inhibitory factor-1, ..
  8. ncbi Quantum proteolytic activation of chemokine CCL15 by neutrophil granulocytes modulates mononuclear cell adhesiveness
    Rudolf Richter
    IPF PharmaCeuticals GmbH, Hannover, Germany
    J Immunol 175:1599-608. 2005
    ..We show here that neutrophils may support this process by activation of CCL15, a human chemokine circulating in blood plasma...
  9. doi A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa
    K Kotarsky
    Immunology Section, Department of Experimental Medical Sciences, Lund University, Lund, Sweden
    Mucosal Immunol 3:40-8. 2010
    ..Finally, the human homologs to CCL6, CCL14 and CCL15 were also constitutively expressed at high levels in human intestinal epithelium, were further enhanced in ..
  10. ncbi Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1
    S Zhang
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202, USA
    J Immunol 162:4938-42. 1999
    ..2 nM and 1.1 nM, respectively. We conclude that CCR1 is a receptor mediating responses to both MIP-1 alpha and Lkn-1 on neutrophils and produces different biological responses depending on the ligand bound...
  11. ncbi PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells
    Sang Min Lee
    Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin, Kyunggi do 449 701, Republic of Korea
    Biochem Biophys Res Commun 324:768-72. 2004
    ..focal staining of CCR1 appeared on the periphery of the membrane upon short exposure to Leukotactin-1(Lkn-1)/CCL15, a CCR1 agonist, and was costained with PLP2/A4 on the focal regions...
  12. doi Macrophage inflammatory protein-1 delta: a novel osteoclast stimulating factor secreted by renal cell carcinoma bone metastasis
    Scott L Kominsky
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cancer Res 68:1261-6. 2008
    ....
  13. doi Liver resection associated with mini porto-caval shunt as salvage treatment in patients with progression of hepatocellular carcinoma before liver transplantation: a case report
    M Polacco
    Unità di Chirurgia Epatobiliare e Trapianto Epatico, Dipartimento assistenziale di chirurgia generale e trapianti d organo, Universita degli Studi di Padova, Padova, Italy
    Transplant Proc 42:1378-80. 2010
    ..Associating a partial side-to-side PCS with hepatic resection may represent a potential salvage therapy for patients with decompensated cirrhosis and HCC progression beyond listing criteria for OLT...
  14. ncbi Isolation and characterization of the 5'-flanking sequence of the human ocular lens MIP gene
    X Y Wang
    Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Gene 167:321-5. 1995
    ..regulatory elements underlying its tissue specificity and ontogenic profile, we have cloned 2840 bp of the human MIP 5'-flanking sequence...
  15. pmc Chemokine Lkn-1/CCL15 enhances matrix metalloproteinase-9 release from human macrophages and macrophage-derived foam cells
    Sang Hee Kwon
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, Korea
    Nutr Res Pract 2:134-7. 2008
    ..Leukotactin-1 (Lkn-1/CCL15), a new member of the human CC chemokine family, is a potent chemoattractant for leukocytes...
  16. ncbi Expression of lymphocyte-specific chemokines in human malignant glioma: Essential role of LARC in cellular immunity of malignant glioma
    T Kimura
    Department of Neurosurgery, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan
    Int J Oncol 21:707-15. 2002
    ..001). Although the constitutive expression level of LARC is low, certain stimulations could strongly induce its expression, and play a crucial role in the tumor immunity of human malignant glioma...
  17. ncbi Longitudinal craniofacial growth patterns in patients with orofacial clefts: geometric morphometrics
    G D Singh
    School of Medicine, University of Puerto Rico, San Juan, Puerto Rico
    Cleft Palate Craniofac J 41:136-43. 2004
    ..To demonstrate craniofacial developmental patterns in repaired cleft lip and cleft palate (CLP)...
  18. doi Leukotactin-1/CCL15 induces cell migration and differentiation of human eosinophilic leukemia EoL-1 cells through PKCdelta activation
    Ji Sook Lee
    Department of Biology, College of Natural Sciences, Daejeon University, Daejeon, 300 716, Republic of Korea
    Mol Biol Rep 37:2149-56. 2010
    Leukotactin-1 (Lkn-1)/CCL15 is a CC chemokine that binds to the CCR1 and CCR3. Lkn-1 functions as an essential factor in the migration of monocytes, lymphocytes, and neutrophils...
  19. ncbi Clinical usefulness of computed tomography arteriography and computed tomography during arterial portography for the diagnosis of early and early advanced hepatocellular carcinoma
    T Ichikawa
    Department of Radiology, Tama Nagayama Hospital, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 67:105-9. 2000
    ..4) CONCLUSIONS: A combination of CTA and CTAP is useful for the diagnosis of early HCC and early advanced HCC...
  20. pmc Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model
    Takanori Kitamura
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 107:13063-8. 2010
    ..for liver dissemination, we show that mouse and human colon cancer cells secrete CC-chemokine ligands CCL9 and CCL15, respectively, and recruit CD34(+) Gr-1(-) immature myeloid cells (iMCs)...
  21. doi A new gland associated with the retrocerebral complex of the adult corn earworm, Helicoverpa zea
    Ashok Raina
    Formosan Subterranean Termite Research Unit, USDA, ARS, 1100 Robert E Lee Boulevard, New Orleans, LA 70124, USA
    Arthropod Struct Dev 37:535-8. 2008
    ..The cytoplasm has an abundance of mitochondria in addition to dense bodies, electron lucent spheres, concentric whorls of rough endoplasmic reticulum and few vacuoles. At this stage we have no idea as to the function of this new gland...
  22. ncbi Involvement of leukotactin-1, a novel CC chemokine, in human atherosclerosis
    Rina Yu
    Department of Food Science and Nutrition, University of Ulsan, Ulsan 680 749, South Korea
    Atherosclerosis 174:35-42. 2004
    ..Lkn-1 stimulated endothelial cells to release ICAM-1, which is implicated in atherogenesis. Taken together, our data suggest that Lkn-1 plays an important role in the development of atherosclerosis...
  23. ncbi Genomic organization of the genes for human and mouse CC chemokine LEC
    S Fukuda
    Department of Biochemistry, Kumamoto University Medical School, Honjo, Japan
    DNA Cell Biol 18:275-83. 1999
    ..Southern blot analysis revealed that the sequence isolated from the BAC clone was the only one hybridizing with human LEC cDNA in the mouse genome. Therefore, mice may have only an LEC pseudogene...
  24. pmc Identification of two novel CT antigens and their capacity to elicit antibody response in hepatocellular carcinoma patients
    X Y Dong
    Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Br J Cancer 89:291-7. 2003
    ..0% (six out of 24), respectively, in HCC patients bearing respective gene transcripts. Therefore, FATE/BJ-HCC-2 and TPTE/BJ-HCC-5 are the novel CT antigens capable of eliciting antibody response in cancer patients...
  25. ncbi Extent of resection for hepatocellular carcinoma 2 cm or less in greatest diameter
    Masakazu Yamamoto
    Department of Surgery, Institute of Gastroenterology, Tokyo Women s Medical University, 8 1, Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Am J Surg 184:437-40. 2002
    ..The effectiveness of liver segmentectomy or larger resection in patients with hepatocellular carcinoma (HCC) 2 cm or less in greatest diameter has not been clarified...
  26. ncbi Correlation of HBV and HCV with CH, LC, HCC in liver biopsied tissue at Rajavithi Hospital
    Arunluck Komindr
    Department of Pathology, Rajavithi Hospital, 2 Rajavithi Rd, Bangkok 10400, Thailand
    J Med Assoc Thai 88:788-809. 2005
    ....
  27. doi Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding
    Pia C Jensen
    Department of Neuroscience and Pharmacology, Copenhagen University, Blegdamsvej 3, DK 2200, Copenhagen, Denmark
    J Biol Chem 283:23121-8. 2008
    ....
  28. doi Functional imaging of the parietal cortex during action execution and observation
    Mina N Evangeliou
    Department of Basic Sciences, Faculty of Medicine, School of Health Sciences, University of Crete, Iraklion, Crete, Greece
    Cereb Cortex 19:624-39. 2009
    ....
  29. doi Hepatocellular carcinoma in renal transplant recipients
    C H Chuang
    Department of Nephrology, Renal Transplant Program, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Transplant Proc 40:2392-4. 2008
    ..We performed a retrospective study to investigate the clinical features of HCC among our renal transplant recipients...
  30. ncbi Inhibition of respiratory syncytial virus infection with the CC chemokine RANTES (CCL5)
    Matthew B Elliott
    Department of Immunology Research, Wyeth Vaccines Research, Pearl River, New York 10965, USA
    J Med Virol 73:300-8. 2004
    ..Other recombinant chemokines (MIP-1alpha/CCL3, MIP-1beta/CCL4, MCP-2/CCL8, eotaxin/CCL11, MIP-1delta/CCL15, stromal cell derived factor (SDF)-1alpha/CXCL12) were not inhibitory...
  31. ncbi Tagma-specific distribution of FXPRLamides in the nervous system of the American cockroach
    R Predel
    Institut für Allgemeine Zoologie und Tierphysiologie, Friedrich Schiller Universtät, D 07743 Jena, Germany
    J Comp Neurol 419:352-63. 2000
    ..It is likely that the expression of pyrokinins in the central nervous system is tagma (body region)-specific. Pea-PK-6 was identified during this study as follows: Ser-Glu-Ser-Glu-Val-Pro-Gly-Met-Trp-Phe-Gly-Pro-Arg-Leu-NH(2)...
  32. ncbi Leukotactin-1/CCL15-induced chemotaxis signaling through CCR1 in HOS cells
    Jesang Ko
    Immunomodulation Research Center, University of Ulsan, 680 749, Ulsan, South Korea
    FEBS Lett 515:159-64. 2002
    Leukotactin-1 (Lkn-1)/CCL15 is a recently cloned CC-chemokine that binds to the CCR1 and CCR3...
  33. ncbi Differentiation of CD34+ cells from human cord blood and murine bone marrow is suppressed by C6 beta-chemokines
    In Seob Han
    The Immunomodulation Research Center and Department of Biological Sciences, University of Ulsan, Ulsan 680 748, Korea
    Mol Cells 15:176-80. 2003
    ..The inhibitory activity of these chemokines suggests that they may protect hematopoietic progenitors from the cytotoxic effects of the antiblastic drugs used in cancer therapy...
  34. ncbi CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells
    Adriana R Mantegazza
    Fundacion Instituto Leloir, Av Patricias Argentinas 435, 1405 Capital Federal, Argentina
    Blood 104:1183-90. 2004
    ..However, only CD63 would intervene in the internalization of complex antigens...
  35. ncbi Immunohistochemical analysis of the expression of FATE/BJ-HCC-2 antigen in normal and malignant tissues
    Xiao Ang Yang
    Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Lab Invest 85:205-13. 2005
    ..Thus, FATE/BJ-HCC-2 may be a valuable candidate CT antigen for polyvalent vaccines in tumor immunotherapy and an assisting diagnostic marker for prognosis of the disease...
  36. ncbi The comparative study on ultrastructure and immunohistochemistry in AFP negative and positive hepatocellular carcinoma
    Meirong Zheng
    Department of Ultrastructural Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 24:547-9, 559. 2004
    ....
  37. ncbi Patterns of protein expression in infectious meningitis: a cerebrospinal fluid protein array analysis
    Stefan Kastenbauer
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    J Neuroimmunol 164:134-9. 2005
    ..g., macrophage inflammatory protein-1delta (CCL15) and neutrophil-activating peptide-2 (CXCL7)...
  38. ncbi Chlorophyll breakdown in spinach: on the structure of five nonfluorescent chlorophyll catabolites
    Joachim Berghold
    Institute of Organic Chemistry, Leopold Franzens Universitat Innsbruck, Innrain 52a, 6020, Innsbruck, Austria
    Photosynth Res 74:109-19. 2002
    ..The transformation of the tetrapyrrolic skeleton in chlorophyll catabolism in spinach and in C. japonicum is revealed to exhibit a common stereochemical pattern...
  39. ncbi Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines
    Sung Wuk Jang
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    J Cell Physiol 211:630-7. 2007
    ..These data indicate that LZIP functions as a positive regulator in the NF-kappaB activation pathway that is triggered by Lkn-1 without affecting the transcriptional activation of NF-kappaB induced by other CCR1-dependent chemokines...
  40. pmc Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration
    Ho Joong Sung
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    Exp Mol Med 40:332-8. 2008
    ..Human LZIP is an uncharacterized transcription factor and is known to participate in leukotactin (Lkn)-1/CCL15-induced cell migration...
  41. ncbi Brain metastasis from hepatocellular carcinoma treated with a cyber-knife
    Atsushi Hiraoka
    Department of Gastroenterology, Ehime Prefectural Central Hospital, Matsuyama
    Intern Med 47:1993-6. 2008
    ..The prognosis of patients with brain metastasis from HCC has been reported to be poor. Use of the cyber-knife was non-invasive, and proved to be effective for improving prognosis and quality of life...
  42. doi Isoreticular metal-organic polyhedral networks based on 5-connecting paddlewheel motifs
    Hyungphil Chun
    Department of Applied Chemistry, College of Science and Technology, Hanyang University, 1271, Sa 3 dong, Ansan 426 791, Republic of Korea
    Inorg Chem 48:2043-7. 2009
    ..ZmID, ZID, and CID are all similar in terms of the H(2) sorption capacities (1.4-1.5 wt % at 77 K and 1 bar) and isosteric heat of H(2) adsorption (6-7 kJ/mol at low coverage)...
  43. pmc Tissue expression of Squamous Cellular Carcinoma Antigen (SCCA) is inversely correlated to tumor size in HCC
    Paolo Trerotoli
    Department of Internal Medicine, Immunology and Infectious Diseases, Section of Internal Medicine, University of Bari Medical School, Bari, Italy
    Mol Cancer 8:29. 2009
    ..We studied 27 patients with liver cirrhosis (LC) and 55 with HCC: 20 with a single nodule < 3 cm (s-HCC) and 35 with a single nodule > 3 cm or multifocal (l-HCC)...
  44. doi 18F-FDG-PET and histopathology in 131I-lipiodol treatment for primary liver cancer
    Jörn H Risse
    Radiology and Nuclear Medicine Institute, Bad Honnef, Germany
    Cancer Biother Radiopharm 24:445-52. 2009
    ..In conclusion, large HCCs were significantly more often PET positive, but there was no correlation with the degree of differentiation. Follow-up PET may be useful if the tumor is first demonstrated to be FDG positive...
  45. doi Mycobacterium tuberculosis-induced expression of Leukotactin-1 is mediated by the PI3-K/PDK1/Akt signaling pathway
    Jang Eun Cho
    Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University, Wonju, 220 710, Korea
    Mol Cells 29:35-9. 2010
    ..These results suggest that Lkn-1 is novel member of the group of chemokines that is released by macrophages infected with MTB...
  46. doi Predictors for microinvasion of small hepatocellular carcinoma ≤ 2 cm
    Yo ichi Yamashita
    Department of Surgery, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Japan
    Ann Surg Oncol 19:2027-34. 2012
    ..Hepatocellular carcinoma (HCC) ≤ 2 cm in diameter is considered to have a low potential for malignancy...
  47. doi Impact of diffusion-weighted MR imaging on the characterization of small hepatocellular carcinoma in the cirrhotic liver
    François Le Moigne
    Department of Radiology, La Croix Rousse Hospital, 103 Grande Rue de la Croix Rousse, 69004 Lyon, France
    Magn Reson Imaging 30:656-65. 2012
    ....
  48. doi Alpha-fetoprotein has no prognostic role in small hepatocellular carcinoma identified during surveillance in compensated cirrhosis
    Edoardo G Giannini
    Dipartimento di Medicina Interna, Unita di Gastroenterologia, Universita di Genova, Italy
    Hepatology 56:1371-9. 2012
    ..536, 95% confidence interval = 0.465-0.606) to discriminate between survivors and deceased patients...
  49. doi [Biological function explore of protein CCL15 in HCC cell lines]
    Yue Guo Li
    Department of Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
    Zhonghua Gan Zang Bing Za Zhi 20:372-6. 2012
    To explain biological function of protein CCL15 in HCC cell lines. The different expression level of CCL15 among HCC cell lines was validated by RT-PCR and Western blot...
  50. pmc CC-chemokine CCL15 expression and possible implications for the pathogenesis of IgE-related severe asthma
    Yasuo Shimizu
    Department of Pulmonary Medicine, Maebashi Red Cross Hospital, 3 21 36 Asahi cho, Gunma, Maebashi 371 0014, Japan
    Mediators Inflamm 2012:475253. 2012
    ..The chemokine CCL15 is influenced by omalizumab, and the source of CCL15 has been reported to be airway smooth muscle cells and ..
  51. doi Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis
    Yoshiro Itatani
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Gastroenterology 145:1064-1075.e11. 2013
    ..In mice, colon tumors that express CCL9 recruit CCR1(+) myeloid cells, which facilitate tumor invasion and metastasis by secreting matrix metalloproteinase 9...
  52. pmc Inflammatory Chemokines MIP-1δ and MIP-3α Are Involved in the Migration of Multipotent Mesenchymal Stromal Cells Induced by Hepatoma Cells
    Esma Lejmi
    1 Surgical Research Unit, University Hospitals of Geneva, Geneva, Switzerland
    Stem Cells Dev 24:1223-35. 2015
    ..In conclusion, we report that two inflammatory cytokines, MIP-1δ and MIP-3α, are able to increase MSC migration in vitro. These cytokines might be responsible for migration and evolvement of MSC into myofibroblasts around tumors. ..
  53. doi Surgical Resection Versus Radiofrequency Ablation for Single Hepatocellular Carcinoma ≤ 2  cm in a Propensity Score Model
    Po Hong Liu
    Department of Medicine, Taipei Veterans General Hospital Faculty of Medicine, National Yang Ming University School of Medicine, Taiwan
    Ann Surg 263:538-45. 2016
    ..To evaluate the efficacy of surgical resection (SR) and radiofrequency ablation (RFA) for single hepatocellular carcinoma (HCC) 2  cm or less...
  54. doi CCL15/CCR1 axis is involved in hepatocellular carcinoma cells migration and invasion
    Yueguo Li
    Department of Clinical Laboratory, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, People s Republic of China
    Tumour Biol 37:4501-7. 2016
    ..Results from our previous study indicated that CCL15 can be a specific proteomic biomarker of hepatocellular carcinoma, which plays an important role in tumorigenesis ..
  55. pmc Follicular thyroid carcinoma but not adenoma recruits tumor-associated macrophages by releasing CCL15
    Feng jiao Huang
    Shanghai Key Laboratoryfor Endocrine Tumors, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E institute for Endocrinology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, 197 Ruijin 2nd Road, Shanghai, 200025, P R China
    BMC Cancer 16:98. 2016
    ..Many efforts have been made but most focusing on tumor cells, while the roles of tumor associated macrophages (TAMs) remained unclear in FTC. Here we analyzed the differences between TAMs in FTC and those in FA...
  56. doi Epidemiology and outcomes of hepatitis C infection in elderly US Veterans
    H B El-Serag
    Center for Innovations in Quality, Effectiveness and Safety, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas, USA
    J Viral Hepat 23:687-96. 2016
    ..However, receipt of curative treatment is associated with a benefit in reducing cirrhosis, HCC and overall mortality, irrespective of age. ..
  57. pmc Disease-specific dynamic biomarkers selected by integrating inflammatory mediators with clinical informatics in ARDS patients with severe pneumonia
    Chengshui Chen
    Department of Respiratory Medicine, The Second Affiliated Hospital of Xi an Jiaotong University, Xi an, 710004, China
    Cell Biol Toxicol 32:169-84. 2016
    ..Our preliminary study suggested that integration of proteomic profiles with clinical informatics as part of clinical bioinformatics is important to validate and optimize disease-specific and disease-staged biomarkers...
  58. pmc Hoarseness due to lymph node metastasis of hepatocellular carcinoma: A case report
    Lin Xu
    Department of Hepatopancreatobiliary Surgery, the Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P R China
    Oncol Lett 12:918-920. 2016
    ..The patient had undergone right hepatic lobectomy for HCC 2 years prior and received transarterial chemoembolization 4 times following resection...
  59. ncbi The assembly of thiophene-based bis-pyridyl-bis-amide CoII coordination polymers and their polypyrrole-functionalized hybrid materials for boosting their photocatalytic performances
    Xiu Li Wang
    Department of Chemistry, Bohai University, Jinzhou, 121000, P R China
    Dalton Trans 45:19341-19350. 2016
    ..As a result, after being decorated with PPy, the photocatalytic properties of the hybrid materials, particularly PPy/CP3, have been observably enhanced for the degradation of methylene blue (MB) under visible light irradiation...
  60. ncbi Exposure to chemokines during maturation modulates antigen presenting cell function of mature macrophages
    Jae Kwon Lee
    College of Pharmacy, Chungbuk National University, Cheongju 361 763, Republic of Korea
    Cell Immunol 234:1-8. 2005
    ..These results suggest that the acquisition of APC function of mature macrophage is modulated significantly by the microenvironmental condition during development...
  61. ncbi Polarity and hydrophobicity interactions in protein synthesis process
    Xu qing Li
    Department of Biomedical Engineering, Kunming University of Science and Technology, Kunming 650051, PR China
    J Theor Biol 240:87-97. 2006
    ..TGG3' or 5'TGG...NCC3' which may perform as functional segments of rRNAs to help triggering the reaction of peptide formation, and common ..
  62. doi Autoantibodies to CCL3 are of low sensitivity and specificity for the diagnosis of type 1 diabetes
    Gan Huang
    Diabetes Center, 2nd Xiangya Hospital, Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, Hunan, China
    Acta Diabetol 49:395-9. 2012
    ..9633 and 0.4095 vs. 0.0873, P = 0.012 and P = 0.034, respectively). We conclude that autoantibodies to CCL3 are of low sensitivity and specificity for T1D and cannot be used in the diagnosis of T1D...
  63. pmc Science to practice: what do molecular biologic studies in rodent models add to our understanding of interventional oncologic procedures including percutaneous ablation by using glyceraldehyde-3-phosphate dehydrogenase antagonists?
    S Nahum Goldberg
    Image guided Therapy and Interventional Oncology Unit, Department of Radiology Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Radiology 262:737-9. 2012
    ....
  64. pmc Two Blood Monocytic Biomarkers (CCL15 and p21) Combined with the Mini-Mental State Examination Discriminate Alzheimer's Disease Patients from Healthy Subjects
    Tanja Hochstrasser
    Laboratory of Psychiatry and Experimental Alzheimer s Research, Department of Psychiatry and Psychotherapy, Innsbruck Medical University, Innsbruck, Austria
    Dement Geriatr Cogn Dis Extra 1:297-309. 2011
    ..In AD, monocytes migrate across the blood-brain barrier and differentiate into microglia, are linked to inflammatory responses and display age-dependent decreases in telomere lengths...
  65. doi Percutaneous pedicle screw implantation for refractory low back pain: from manual 2D to fully robotic intraoperative 2D/3D fluoroscopy
    C Raftopoulos
    Department of Neurosurgery and Neuroradiology, Clinique Universitaire St Luc, Brussels, Belgium
    Adv Tech Stand Neurosurg 38:75-93. 2012
    ....
  66. ncbi Early recurrence after curative resection in oligonodular hepatocellular carcinoma
    Liang Huang
    Department of Hepatic Surgery I, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
    Hepatogastroenterology 60:28-31. 2013
    ..We conducted this retrospective study to observe the recurrence rate within 1 year after hepatectomy for oligonodular HCC (2 or 3 nodules) and investigate the risk factors for early recurrence...
  67. doi CCR1-mediated STAT3 tyrosine phosphorylation and CXCL8 expression in THP-1 macrophage-like cells involve pertussis toxin-insensitive Gα(14/16) signaling and IL-6 release
    Maggie M K Lee
    Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Immunol 189:5266-76. 2012
    ..In this study, we demonstrated that a CCR1 agonist, leukotactin-1 (CCL15), could indeed stimulate STAT3 Tyr(705) and Ser(727) phosphorylation via pertussis toxin-insensitive G proteins in ..
  68. doi Activation of the nuclear receptor FXR enhances hepatocyte chemoprotection and liver tumor chemoresistance against genotoxic compounds
    Javier Vaquero
    University of Salamanca, Salamanca, Spain
    Biochim Biophys Acta 1833:2212-9. 2013
    ..Investigation of 109 genes potentially involved in chemoresistance revealed that only ABCB4, TCEA2, CCL14, CCL15 and KRT13 were up-regulated by FXR activation both in human hepatocytes and FXR/RXR-expressing hepatoma cells...
  69. ncbi 240 hepatocellular carcinomas: ultrasound features, tumor size, cytologic and histologic patterns, serum alpha-fetoprotein and HBs Ag
    T Livraghi
    Servizio di Radiologia, Ospedale Civile, Vimercate, Italia
    Tumori 73:507-12. 1987
    ..Since the discovery of a small HCC is an incidental ultrasonographic finding in the context of severe liver disease, ultrasonographic monitoring of cirrhotic patients is the best available strategy to screen for small HCC...
  70. ncbi The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases
    T N Wells
    Geneva Biomedical Research Institute, Switzerland
    J Leukoc Biol 61:545-50. 1997
    ....
  71. ncbi Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 159:1993-2000. 1997
    ..Chemokines may play a role in the trafficking of DC under resting or stimulated conditions. Chemokine receptors expressed in DC are likely to underlie HIV infection of this cell type...
  72. ncbi Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines
    F Coulin
    Geneva Biomedical Research Institute, Switzerland
    Eur J Biochem 248:507-15. 1997
    ..Consistent with this binding data, MIP-5 was only able to induce calcium fluxes in CHO cells stably transfected with CCR1 or CCR3...
  73. ncbi Molecular cloning and functional characterization of human MIP-1 delta, a new C-C chemokine related to mouse CCF-18 and C10
    W Wang
    Department of Immunobiology, DNAX Research Institute, Palo Alto, California 94304, USA
    J Clin Immunol 18:214-22. 1998
    ..Human MIP-1 delta is chemotactic for T cells and monocytes, but not for neutrophils, eosinophils, or B cells. Human MIP-1 delta induced calcium flux in human CCR1-transfected cells...
  74. ncbi Solution structure of the human CC chemokine 2: A monomeric representative of the CC chemokine subtype
    H Sticht
    Lehrstuhl für Biopolymere, Universitat Bayreuth, D 95440 Bayreuth, Germany
    Biochemistry 38:5995-6002. 1999
    ..Structural investigations with a HCC-2 mutant prove that a third additional disulfide bond present in wild-type HCC-2 is not necessary for maintaining the relative orientation of the helix and the beta-sheet...
  75. pmc Different gene expression of MDM2, GAGE-1, -2 and FHIT in hepatocellular carcinoma and focal nodular hyperplasia
    T Schlott
    Department of Cytopathology, Georg August University, Goettingen, Germany
    Br J Cancer 80:73-8. 1999
    ..In contrast, MDM2 mutations and GAGE-1, -2 expression were associated with HCC specimens. Therefore, the RT-PCR assays for GAGE-1, -2 and MDM2 might be useful adjuncts in cytodiagnosis of liver neoplasms...
  76. ncbi [Albumin mRNA and pCEA in the histopathologic diagnosis of hepatocellular carcinoma]
    M P Foschini
    Dipartimento di Oncologia, Ospedale Bellaria, Universita di Bologna
    Pathologica 91:260-7. 1999
    ..Detection of albumin mRNA showed a higher sensitivity. In addition the cRNA probe here used seems more sensitive that the oligonucleotide probes employed in previous studies...
  77. ncbi Triple co-localisation of two types of allatostatin and an allatotropin in the frontal ganglion of the lepidopteran Lacanobia oleracea (Noctuidae): innervation and action on the foregut
    H Duve
    School of Biological Sciences, Queen Mary and Westfield College, University of London, UK
    Cell Tissue Res 300:153-63. 2000
    ..Y/FXFGL-NH2-immunoreactive material, but not allatotropin or Mas-AS, to the recurrent nerve via NCC 1+2 and NCC 3. All three peptides have a reversible effect on the spontaneous (peristaltic) contractions of the foregut (crop) ..
  78. ncbi Transforming growth factor beta1 and soluble Fas serum levels in hepatocellular carcinoma
    R Sacco
    Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Policlinico, Bari, 70124, Italy
    Cytokine 12:811-4. 2000
    ..However, in the 23% of HCC patients, with normal AFP values TGF-beta1 levels were higher than the cut off. These findings suggest the potential usefulness for TGF-beta1 assay in AFP-negative HCC...
  79. ncbi Truncation of NH2-terminal amino acid residues increases agonistic potency of leukotactin-1 on CC chemokine receptors 1 and 3
    Jae Kwon Lee
    College of Pharmacy and Research Center for Bioresource and Health, Chungbuk National University, Cheongju 361 763, South Korea
    J Biol Chem 277:14757-63. 2002
    ..Our results indicate that posttranslational modification is a potential mechanism for the regulation of biological activity of Lkn-1...
  80. ncbi Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Int Immunol 14:883-92. 2002
    ..e. macrophage inflammatory protein (MIP)-1alpha/CCL3, MIP-1beta/CCL4, MIP-3alpha/CCL20, MIP-5/CCL15, monocyte chemotactic protein (MCP)-1/CCL2, MCP-2/CCL8, MCP-3/CCL7, eotaxin/CCL11 and macrophage-derived chemokine ..
  81. ncbi Chronic liver disease in diabetes mellitus
    D Amarapurkar
    Department of Gastroenterology, Bombay Hospital and Medical Research Center, Mumbai, India
    Trop Gastroenterol 23:3-5. 2002
    ..The association of diabetes with liver disease is well known...
  82. ncbi A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia
    Valerie Paradis
    Service d Anatomie Pathologique and Service de Chirurgie, Hopital Beaujon, Clichy, France
    Gastroenterology 124:651-9. 2003
    ..To gain insight into the pathogenesis of FNH, we performed a large-scale quantitative study of gene expression in FNH...
  83. ncbi Expression of macrophage inflammatory protein-3 beta/CCL19 in pulmonary sarcoidosis
    Agata Gibejova
    Department of Immunology, Palacky University, Olomouc, Czech Republic
    Am J Respir Crit Care Med 167:1695-703. 2003
    ..This novel chemokine, therefore, represents a candidate for studies of sarcoidosis pathobiologic mechanisms...
  84. ncbi Decreasing incidence of hepatocellular carcinoma among children following universal hepatitis B immunization
    Mei Hwei Chang
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Liver Int 23:309-14. 2003
    ..This concept of cancer vaccine can be applied to other infectious agents and their related cancers...
  85. ncbi Purification and refolding of a novel cancer/testis antigen BJ-HCC-2 expressed in the inclusion bodies of Escherichia coli
    Xiao Ang Yang
    Department of Immunology, School of Basic Medical Science, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Protein Expr Purif 33:332-8. 2004
    ..This method of protein purification and refolding is easy to manipulate and may be applicable to the hydrophobic proteins that are unable to be purified by other methods...
  86. ncbi Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines
    Jesang Ko
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea
    FASEB J 18:890-2. 2004
    ....
  87. pmc Favorable surgical outcomes in patients with early hepatocellular carcinoma
    Masakazu Yamamoto
    Department of Surgery, Institute of Gastroenterology, Tokyo Women s Medical University, Tokyo, Japan
    Ann Surg 239:395-9. 2004
    ..However, the surgical outcomes in patients with early HCC have not yet been clarified...
  88. ncbi Macrophage inflammatory protein-1
    M Maurer
    Department of Dermatology, University of Mainz, Langenbeckstr 1, Mainz 55101, Germany
    Int J Biochem Cell Biol 36:1882-6. 2004
    ..These proteins termed CCL3 (MIP-1alpha), CCL4 (MIP-1beta), CCL9/10 (MIP-1delta), and CCL15 (MIP-1gamma) according to the revised nomenclature for chemokines are produced by many cells, particularly ..
  89. ncbi Identification of NH(2)-terminal amino acid residues essential for the biological activity of leukotactin-1
    Jae Kwon Lee
    College of Pharmacy, Chungbuk National University, Cheongju 361 763, South Korea
    Immunol Lett 99:63-8. 2005
    ..These results identify that alanine-aspartic acid residues preceding the first cysteine at the NH(2)-terminus are essential for the binding and biological activity of Lkn-1...
  90. ncbi The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: antagonists versus agonists
    Pauline C Ting
    Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 15:3020-3. 2005
    ..Optimization of the structure-activity relationship of compound 4a has resulted in the identification of a CCR3 antagonist 4i as well as a CCR3 agonist 13...
  91. ncbi Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells
    In Sik Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Republic of Korea
    FEBS Lett 579:6044-8. 2005
    ..of HCC-4 as well as those of other CCR1-dependent chemokines including MIP-1alpha/CCL3, RANTES/CCL5, and Lkn-1/CCL15 was inhibited by the treatment of pertussis toxin, an inhibitor of Gi/Go protein, U73122, an inhibitor of ..
  92. ncbi Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma
    Peter Morin Nissom
    Bioprocessing Technology Institute, 06 01, Centros, 20 Biopolis Way, Singapore 138668, Singapore
    FEBS Lett 580:2216-26. 2006
    ..This work demonstrates that an integrated proteomics and genomics approach can be a very powerful means of discovering potential diagnostic and therapeutic protein targets for cancer therapy...
  93. ncbi Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene
    Maria Carla Bosco
    Laboratory of Molecular Biology, G Gaslini Institute, Genova, Italy
    J Immunol 177:1941-55. 2006
    ..molecules (CD32, CD64, CD69, CD89, CMRF-35H, ITGB5, LAIR1, LIR9), chemokines/cytokines and receptors (CCL23, CCL15, CCL8, CCR1, CCR2, RDC1, IL-23A, IL-6ST)...
  94. ncbi Hypothyroidism: a possible risk factor for liver cancer in patients with no known underlying cause of liver disease
    Arvind Reddy
    Miles and Shirley Fiterman Center for Digestive Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 5:118-23. 2007
    ..Animal studies suggest that hypothyroidism can directly cause liver cell damage and might be a risk factor for HCC. We conducted a case-control study to evaluate the relationship between hypothyroidism and HCC...
  95. ncbi Transplantation for hepatocellular carcinoma: The Milan criteria and beyond
    Richard B Freeman
    Division of Transplant Surgery, Tufts New England Medical Center, Boston, MA 02111, USA
    Liver Transpl 12:S8-13. 2006
    ..5. Liver allocation for HCC candidates in the context of increasing HCC prevalence requires better and evidence-based prioritization policies...
  96. ncbi Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma
    Shi Ming Lin
    Liver Research Unit, Chang Gung University and Chang Gung Memorial Hospital, Taipei, Taiwan
    J Hepatol 46:45-52. 2007
    ..The long-term outcomes of interferon-alpha (IFN-alpha) therapy in hepatitis B e antigen (HBeAg) seropositive patients remain controversial. This study was conducted to address this issue...
  97. ncbi Model for end-stage liver disease score-based allocation of donors for liver transplantation: a spanish multicenter experience
    Manuel De la Mata
    Liver Transplant Unit, Reina Sofia University Hospital, Cordoba, Spain 2Andalusian Transplant Coordinating Office, Sevilla, Spain
    Transplantation 82:1429-35. 2006
    ..We present the experience of four transplant centers in Andalusia (Southern Spain) with a new consensus model of WL management based on the Model for End-Stage Liver Disease (MELD) score...
  98. pmc Induction of host chemotactic response by Encephalitozoon spp
    Jeffrey Fischer
    Department of Biological Sciences, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA
    Infect Immun 75:1619-25. 2007
    ..involved in the inflammatory responses whose expression was upregulated, including CCL1, CCL2, CCL3, CCL4, CCL7, CCL15, CCL20, CXCL1, CXCL2, CXCL3, CXCL5, and CXCL8...
  99. pmc Expression of immunomodulatory genes in human monocytes induced by voriconazole in the presence of Aspergillus fumigatus
    M Simitsopoulou
    Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bldg 10, CRC 1 5750, Bethesda, MD 20892, USA
    Antimicrob Agents Chemother 51:1048-54. 2007
    ..of VRC, a large number of genes such as CCL3 (MIP1A), CCL4 (MIP1B), CCL5 (RANTES), CCL7 (MCP3), CCL11 (EOTAXIN), CCL15 (MIP1Delta), CXCL6, and CXCL13 were strongly up-regulated in THP-1 cells challenged by HF, whereas CCL20 (MIP3A) ..
  100. pmc Glycogen storage disease type III-hepatocellular carcinoma a long-term complication?
    Erin Demo
    Department of Pediatrics, Duke University Medical Center, Box 3528, Durham, NC 27710, USA
    J Hepatol 46:492-8. 2007
    ..Hepatic involvement is considered mild, self-limiting and improves with age. With increased survival, a few cases of liver cirrhosis and hepatocellular carcinoma (HCC) have been reported...
  101. ncbi Somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma
    Shiou Hwei Yeh
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    Int J Cancer 120:1610-7. 2007
    ..In conclusion, the mis-sense somatic mutations of AR were rare in HCC but the TNR change was a more common one, which exclusively occurred in males. Moreover, the length of TNR carried clinical significance in special HCC group...

Research Grants11

  1. Aberrant DNA Methylation of MicroRNA Genes in Hepatocellular Carcinoma (HCC)
    Jing Shen; Fiscal Year: 2012
    ..PHS 398/2590 (Rev. 06/09) Page Continuation Format Page ..
  2. GORDON SHOJI OKIMOTO; Fiscal Year: 2016
    ..This proposal is submitted in response to NIH PA-08-243. ..
  3. Effect of MIP-1 delta on Osteoclast Development and Pathological Bone Resorption
    Scott L Kominsky; Fiscal Year: 2010
    ....
  4. Genes Related to HCC Progression in LD and DD Transplant
    Robert A Fisher; Fiscal Year: 2010
    ..abstract_text> ..
  5. Multigene Kinase Network, Kidney Transport and Salt in Essential Hypertension
    Paul A Welling; Fiscal Year: 2010
    ....
  6. Overcoming Barriers to Early Phase Clinical Trials
    Bruce Chabner; Fiscal Year: 2004
    ....
  7. Systematic Integration POR into Clinical Pathway of HCC
    Myron Schwartz; Fiscal Year: 2006
    ..This program provides a truly remarkable opportunity to make meaningful progress in understanding, preventing and treating HCC, while in the process providing fertile training ground for young physician-scientists. ..
  8. Perilous Effects of Methamphetamine on SIV/AIDS
    Howard Fox; Fiscal Year: 2005
    ..In addition to in vivo and pathological studies, we will perform in vitro studies on CCL15, a proinflammatory chemokine found to be upregulated by METH in astrocytes, and a potential mediator of neuronal ..
  9. Tumor Ablation using Radiofrequency
    S Goldberg; Fiscal Year: 2003
    ..RF tissue heating and coagulation will be compared to determine the best method for increasing RF ablation efficacy in each tumor and tissue model. ..
  10. Enhanced RF Tumor Ablation with Liposomal Chemotherapy
    S Goldberg; Fiscal Year: 2008
    ..abstract_text> ..
  11. Liver Transplantation for Hepatocellular Carcinoma
    Richard Freeman; Fiscal Year: 2005
    ..Furthermore, these analyses will serve to support future developments of prospective clinical trials. ..