CBP

Summary

Gene Symbol: CBP
Description: CREB binding protein
Alias: CBP, KAT3A, RSTS, RSTS1, CREB-binding protein
Species: human

Top Publications

  1. ncbi The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    Haihong Zhong
    Immunobiology Section and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 9:625-36. 2002
  2. ncbi Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
    F C Nucifora
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Science 291:2423-8. 2001
  3. ncbi Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)
    Ralf Janknecht
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 22:746-55. 2003
  4. ncbi HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
    Michael J Gray
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcomb Boulevard, Houston, TX 77030, USA
    Oncogene 24:3110-20. 2005
  5. pmc TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein
    Deborah L Clarke
    Nottingham Respiratory Biomedical Research Unit, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 285:29101-10. 2010
  6. doi Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    Devanand Sarkar
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 68:1478-84. 2008
  7. pmc Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner
    Derek Strassheim
    Pediatric Critical CareMedicine, University of Colorado Denver, Research Complex II, Room 6490, 12700 East 19th Avenue, Aurora, CO 80045, USA
    J Immunol 183:6981-8. 2009
  8. ncbi Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene
    Jong S Rim
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 277:34589-600. 2002
  9. pmc Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300
    W Zhang
    Center for Retrovirus Research and Department of Veterinary Biosciences, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Virol 75:9885-95. 2001
  10. ncbi Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation
    S Y Na
    Department of Biology, Chonnam National University, Kwangju 500 757, South Korea
    J Biol Chem 274:28491-6. 1999

Research Grants

  1. RAJESH K ANEJA; Fiscal Year: 2016
  2. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
  3. Role of Cited2 in Hematopoiesis
    Yu Chung Yang; Fiscal Year: 2011
  4. Histone Acetylation and Insulin Gene Expression
    Sabire Ozcan; Fiscal Year: 2010
  5. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
  6. Coregulatory factor modulation of CREB activity
    ROLAND P KWOK; Fiscal Year: 2010
  7. Zhonghui Guan; Fiscal Year: 2016
  8. John S Davis; Fiscal Year: 2014
  9. John H Byrne; Fiscal Year: 2015
  10. Chemical Modulators for p53 Functions in Transcriptional Regulation
    SYED S MUJTABA; Fiscal Year: 2012

Detail Information

Publications273 found, 100 shown here

  1. ncbi The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    Haihong Zhong
    Immunobiology Section and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 9:625-36. 2002
    ..stimulation causes nuclear localization of NF-kappa B complexes containing phosphorylated p65 that associates with CBP and displaces the p50-HDAC-1 complexes...
  2. ncbi Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
    F C Nucifora
    Division of Neurobiology, Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Science 291:2423-8. 2001
    ..with other proteins containing short polyglutamine tracts such as the transcriptional coactivator CREB binding protein, CBP...
  3. ncbi Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)
    Ralf Janknecht
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 22:746-55. 2003
    ..Consistently, MSK1 interacts with two homologous coactivators of ER81, CBP and p300, and stimulates the transactivation domains of CBP...
  4. ncbi HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
    Michael J Gray
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcomb Boulevard, Houston, TX 77030, USA
    Oncogene 24:3110-20. 2005
    ..bind simultaneously to the VEGF promoter, where they form a molecular complex with the transcription coactivators CBP/p300 and Ref-1/APE...
  5. pmc TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein
    Deborah L Clarke
    Nottingham Respiratory Biomedical Research Unit, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 285:29101-10. 2010
    ..We show, however, that TNFα and IFNγ exert a synergistic effect on the recruitment of CREB-binding protein (CBP) to the CXCL10, which is accompanied by increased RNA polymerase II...
  6. doi Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    Devanand Sarkar
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 68:1478-84. 2008
    ..assays revealed that AEG-1 interacts with cyclic AMP-responsive element binding protein-binding protein (CBP), indicating that it might act as a bridging factor between NF-kappaB, CBP, and the basal transcription machinery...
  7. pmc Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner
    Derek Strassheim
    Pediatric Critical CareMedicine, University of Colorado Denver, Research Complex II, Room 6490, 12700 East 19th Avenue, Aurora, CO 80045, USA
    J Immunol 183:6981-8. 2009
    ..of STAT1-S727 in the transactivation domain, thereby reducing recruitment of the histone acetylase and coactivator CBP/p300 to STAT1; 2) iloprost selectively inhibited activation of JAK2 but not JAK1, both responsible for activation ..
  8. ncbi Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene
    Jong S Rim
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 277:34589-600. 2002
    ..Co-transfections with an Nfe2l2 expression vector and a luciferase reporter construct of the Ucp1 enhancer region provide additional evidence that Nfe2l2 is involved in the regulation of Ucp1 by cAMP-mediated signaling...
  9. pmc Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300
    W Zhang
    Center for Retrovirus Research and Department of Veterinary Biosciences, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Virol 75:9885-95. 2001
    The highly conserved coadapters CREB binding protein (CBP) and p300 form complexes with CREB as well as other DNA binding transcription factors to modulate chromatin remodeling and thus transcription...
  10. ncbi Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation
    S Y Na
    Department of Biology, Chonnam National University, Kwangju 500 757, South Korea
    J Biol Chem 274:28491-6. 1999
    ..These results suggest that Bcl3 may directly participate in the tumorigenesis processes as a novel transcription coactivator of the mitogenic transcription factor AP-1 in vivo...
  11. ncbi Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions
    Luisa Minghetti
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Neurochem Res 29:965-78. 2004
    ....
  12. pmc Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation
    Guillaume Bossis
    Institute of Molecular Genetics of Montpellier, UMR5535 IFR122, CNRS 1919, France
    Mol Cell Biol 25:6964-79. 2005
    ..This supports the idea that this modification does not constitute a final inactivation step that necessarily precedes protein degradation...
  13. ncbi Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation
    Xiaohong Fang
    Department of Pathology and Anatomical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 280:28451-62. 2005
    ..study shows that FGFR1 accumulates and interacts with the transcriptional co-activator CREB-binding protein (CBP) in nuclear speckle domains in the developing brain and in neural progenitor-like cells in vitro, which accompanies ..
  14. ncbi CREB-dependent cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression is mediated by protein kinase C and calcium
    Hung Pham
    Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095 1786, USA
    J Cell Biochem 98:1653-66. 2006
    ..These findings demonstrate a coordinated induction of COX-2 and mPGES-1 by PDB/TG that proceeds through PKC/ERK and Ca2+ signaling cascades, resulting in increased PGE2 production...
  15. pmc Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 28:4275-84. 2008
    ..zinc resulted in the rapid formation of a multiprotein complex containing MTF-1, the histone acetyltransferase p300/CBP, and the transcription factor Sp1...
  16. ncbi Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP
    H Yamamoto
    Department of Cell Genetics, Sasaki Institute, Tokyo, Japan
    Oncogene 18:1495-501. 1999
    ..activity revealed that one of these clones was confirmed to encode a transcriptional coactivator, CREB binding protein (CBP)...
  17. pmc Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation
    Y Wang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Mol Cell Biol 20:4505-12. 2000
    ..Thus, Stat1 acts as a TNFR1-signaling molecule to suppress NF-kappaB activation...
  18. ncbi Inhibitory effect of AP-1 complex on 5-aminolevulinate synthase gene expression through sequestration of cAMP-response element protein (CRE)-binding protein (CBP) coactivator
    Alejandra S Guberman
    Laboratorio de Biologia Molecular, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellon II Piso 4, Ciudad Universitaria, Argentina
    J Biol Chem 278:2317-26. 2003
    ..We also suggest that the transcriptional properties of this AP-1 site would depend on a spatial-disposition-dependent manner with respect to the CRE sites and to the transcription initiation site...
  19. ncbi Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1
    Tomoshige Kino
    Human Retrovirus Section, Center for Basic Research, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    DNA Cell Biol 23:193-205. 2004
    ..Further studies on Vpr function are needed to fully assess the function of this important early regulatory molecule of HIV and other lentiviruses...
  20. ncbi Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors
    T Almlöf
    Department of Biosciences, Karolinska Institute, Huddinge, Sweden
    Biochemistry 37:9586-94. 1998
    ..target proteins showed that the tau 1-core can interact with the C-terminal part of the CREB-binding protein (CBP)...
  21. pmc Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response
    Sonja A Dames
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:5271-6. 2002
    ..conditions, HIF-1 activates transcription of critical adaptive genes by recruitment of the general coactivators CBP/p300 through interactions with its alpha-subunit (Hif-1 alpha)...
  22. ncbi The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
    J Torchia
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 387:677-84. 1997
    The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA...
  23. ncbi A transcriptional switch mediated by cofactor methylation
    W Xu
    Gene Expression Laboratory, Department of Biological Chemistry, University of California Davis Cancer Center Basic Science, Sacramento, CA 95817, USA
    Science 294:2507-11. 2001
    ..based on the controlled methylation of nucleosome and the transcriptional cofactors, the CREB-binding proteins (CBP)/p300...
  24. pmc MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function
    Karin B Kindle
    School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Mol Cell Biol 25:988-1002. 2005
    ..encoding the acetyltransferase MOZ or MORF with genes encoding the nuclear receptor coactivator TIF2, p300, or CBP. Here we show that MOZ-TIF2 acts as a dominant inhibitor of the transcriptional activities of CBP-dependent ..
  25. ncbi Molecular recognition of the human coactivator CBP by the HIV-1 transcriptional activator Tat
    Andrew C Vendel
    Department of Biochemistry and Molecular Biology, Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523 1870, USA
    Biochemistry 42:910-6. 2003
    ..The coactivator and acetyltransferase CREB binding protein (CBP), and the paralog p300, are recruited to the HIV-1 promoter by Tat...
  26. pmc A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions
    C Yang
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 18:2218-29. 1998
    ..M. Leiden, Nature 377:639-642, 1995). Here we show that Ets-1 binds the transcriptional coactivators CREB binding protein (CBP) and the related p300 protein (together referred to as CBP/p300) and that this interaction is required ..
  27. pmc Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein
    M O Hottiger
    Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0650, USA
    J Virol 72:8252-6. 1998
    ..transcriptional activation by HIV-1 Tat involves p300 or the related cellular transcriptional coactivator CREB binding protein (CBP)...
  28. ncbi Signal-specific co-activator domain requirements for Pit-1 activation
    L Xu
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093 0648, USA
    Nature 395:301-6. 1998
    ..N-CoR/SMRT, mSin3A/B and histone deacetylases, and a co-activator complex that includes the CREB-binding protein (CBP) and p/CAF...
  29. ncbi CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1
    K Frønsdal
    Biotechnology Centre of Oslo, University of Oslo, Gaustadalleen 21, 0371 Oslo, Norway
    J Biol Chem 273:31853-9. 1998
    ..We found that CREB (cAMP response element-binding protein) binding protein (CBP) had a direct role in both of these activities of AR...
  30. pmc Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
    S Bhattacharya
    The Dana Farber Cancer Institute and the Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 13:64-75. 1999
    Recruitment of p300/CBP by the hypoxia-inducible factor, HIF-1, is essential for the transcriptional response to hypoxia and requires an interaction between the p300/CBP CH1 region and HIF-1alpha...
  31. ncbi Synergistic activation of the inhibin alpha-promoter by steroidogenic factor-1 and cyclic adenosine 3',5'-monophosphate
    M Ito
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Mol Endocrinol 14:66-81. 2000
    ..Expression of CREB binding protein (CBP), a coactivator that interacts with SF-1 and CREB, further enhanced transcription by these pathways...
  32. ncbi Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator
    A Marcello
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    IUBMB Life 51:175-81. 2001
    ..transcriptional coactivators p300 and the highly homologue cAMP-responsive transcription factor binding protein (CBP)...
  33. pmc Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism
    Séverine Boulon
    Institut de Genetique Moleculaire, CNRS, UMR 5535, IFR24, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 22:7769-79. 2002
    ..that target the CRE-binding factor CREB, which can recruit the transcriptional coactivator CREB-binding protein (CBP)...
  34. ncbi Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP
    Takuji Hirose
    Department of Genome Science, Institute of Medical Science, St Marianna University School of Medicine, Kawasaki 216 8512, Japan
    Int J Mol Med 11:705-12. 2003
    b>CREB binding protein (CBP) plays a central role in cell differentiation and proliferation, interacting with a large number of nuclear factors...
  35. ncbi Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock
    SunHwa Hong
    Department of Molecular Biology, Pusan National University, Busan 609 735, South Korea
    FEBS Lett 559:165-70. 2004
    ..signal cointegrator (ASC)-2 and weakly with cyclic adenosine monophosphate responsive element binding protein (CBP)...
  36. ncbi A review of HIV-1 Tat protein biological effects
    A Pugliese
    Department of Medical and Surgical Sciences, Section of Clinical Microbiology of Turin University, Amedeo di Savoia Hospital, Italy
    Cell Biochem Funct 23:223-7. 2005
    ..The effective role of HIV-1 Tat protein in promoting viral replication and its high immunogenicity suggest useful employment of this protein for therapeutic or preventive vaccine preparations...
  37. pmc Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment
    Charles E Foulds
    Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah, Salt Lake City, UT 84112 5550, USA
    Mol Cell Biol 24:10954-64. 2004
    ..Pointed (PNT) domains, resulted in enhanced transactivation by preferential recruitment of the coactivators CREB binding protein (CBP) and p300...
  38. ncbi Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase
    Inge Bauer
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, D 66421 Homburg, Germany
    Arch Biochem Biophys 438:36-52. 2005
    ..The fact that Egr-1 promoter/reporter gene transcription is upregulated by a constitutively active CREB mutant indicates that the CRE couples other signaling cascades via CREB to the Egr-1 gene...
  39. ncbi Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 280:40450-64. 2005
    ..Thus, acetylation of PARP-1 by p300/CREB-binding protein plays an important regulatory role in NF-kappaB-dependent gene activation by enhancing its functional interaction with p300 and the Mediator complex...
  40. ncbi A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
    X J Yang
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Nature 382:319-24. 1996
    The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families...
  41. ncbi A signature motif in transcriptional co-activators mediates binding to nuclear receptors
    D M Heery
    Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, London, UK
    Nature 387:733-6. 1997
    ..and promotes their association with a diverse group of nuclear proteins, including SRC-1/p160, TIF-2/GRIP-1 and CBP/p300 which function as co-activators of transcription, and RIP-140, TIF-1 and TRIP-1/SUG-1 whose functions are ..
  42. pmc The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
    J J Voegel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, IGBMC CNRS INSERM ULP Collège de France, Strasbourg
    EMBO J 17:507-19. 1998
    ..TIF2 AD1 activity appears to be mediated through CBP, as AD1 could not be separated mutationally from the CBP interaction domain...
  43. pmc Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300
    F Bex
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8594, USA
    Mol Cell Biol 18:2392-405. 1998
    ..Transcriptional activation of these pathways is mediated by the actions of the related coactivators CREB binding protein (CBP) and p300...
  44. pmc Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 18:2986-96. 1998
    ..Interestingly, virus infection resulted in the association of IRF-3 with the CREB binding protein (CBP) coactivator, as detected by coimmunoprecipitation with anti-CBP antibody, an interaction mediated by ..
  45. ncbi Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo
    M G Wathelet
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell 1:507-18. 1998
    ..transcriptional activator proteins (IRF-3 and IRF-7), as well as the transcriptional coactivator proteins p300 and CBP. Remarkably, VAF, as well as recombinant IRF-3 and IRF-7 proteins, binds very weakly to the interferon-beta (IFN-..
  46. pmc Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1
    H M Sheppard
    Department of Biochemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom
    Mol Cell Biol 21:39-50. 2001
    ..proteins, including steroid receptor coactivator 1 (SRC1) and its homologues and the general coactivators CREB binding protein (CBP) and p300...
  47. pmc Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein
    I Kitabayashi
    Cancer Genomics Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    EMBO J 20:7184-96. 2001
    ..MOZ, as well as CBP and MOZ-CBP, can acetylate AML1 in vitro...
  48. ncbi Mutations and deletions of the CBP gene in human lung cancer
    Masahiro Kishimoto
    Biology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 Chome Chuo Ku, Tokyo 104 0045, Japan
    Clin Cancer Res 11:512-9. 2005
    ..analysis led us to detect a homozygous deletion at the cyclic AMP response element binding protein-binding protein (CBP) locus in a lung cancer cell line...
  49. pmc Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation
    Chul Won Lee
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:19290-5. 2010
    ..Although acetylation of p53 by CREB-binding protein (CBP)/p300 is known to be indispensable for p53 activation, the role of phosphorylation, and in particular multisite ..
  50. ncbi The gamma catenin/CBP complex maintains survivin transcription in β-catenin deficient/depleted cancer cells
    Yong mi Kim
    Childrens Hospital Los Angeles, Department of Pediatrics, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA
    Curr Cancer Drug Targets 11:213-25. 2011
    Previously, we demonstrated that survivin expression is CBP/β-catenin/TCF-dependent...
  51. ncbi Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
    F Petrij
    Department of Human Genetics, Leiden University, Sylvius Laboratories, The Netherlands
    Nature 376:348-51. 1995
    ..Here we report that all these breakpoints are restricted to a region that contains the gene for the human CREB binding protein (CBP), a nuclear protein participating as a co-activator in cyclic-AMP-regulated gene expression...
  52. ncbi Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
    J R Lundblad
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 374:85-8. 1995
    The 265K nuclear protein CBP was initially identified as a co-activator for the protein kinase A (PKA)-phosphorylated form of the transcription factor CREB...
  53. pmc SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx
    Hong Yi Kuo
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan 11529, Republic of China
    Proc Natl Acad Sci U S A 102:16973-8. 2005
    ..Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling ..
  54. pmc Inactivating mutations of acetyltransferase genes in B-cell lymphoma
    Laura Pasqualucci
    Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Nature 471:189-95. 2011
    ..These results identify CREBBP/EP300 mutations as a major pathogenetic mechanism shared by common forms of B-cell non-Hodgkin's lymphoma, with direct implications for the use of drugs targeting acetylation/deacetylation mechanisms...
  55. ncbi Nuclear protein CBP is a coactivator for the transcription factor CREB
    R P Kwok
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 370:223-6. 1994
    ..We have previously identified a nuclear protein of M(r)265K, CBP, that binds specifically to the PKA-phosphorylated form of CREB...
  56. ncbi Activation of cAMP and mitogen responsive genes relies on a common nuclear factor
    J Arias
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, California 92037
    Nature 370:226-9. 1994
    ..Recent work describing a phospho-CREB binding protein (CBP) which interacts specifically with the CREB trans-activation domain prompted us to examine whether CBP ..
  57. ncbi Phosphorylated CREB binds specifically to the nuclear protein CBP
    J C Chrivia
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 365:855-9. 1993
    ..that CREB phosphorylated by protein kinase A binds specifically to a nuclear protein of M(r) 265K which we term CBP (for CREB-binding protein)...
  58. ncbi A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
    Y Kamei
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, 92093 0648, USA
    Cell 85:403-14. 1996
    ..Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for limiting amounts of CBP/p300 in ..
  59. ncbi The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
    J Borrow
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nat Genet 14:33-41. 1996
    ..Positional cloning on chromosome 16 implicates the CREB-binding protein (CBP), a transcriptional adaptor/coactivator protein...
  60. pmc Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling
    J J Zhang
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 93:15092-6. 1996
    ..We show here that Stat1 can directly interact with the CREB-binding protein (CBP)/p300 family of transcriptional coactivators...
  61. ncbi Synergistic activation of transcription by CBP and p53
    W Gu
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York 10021, USA
    Nature 387:819-23. 1997
    ..Here we demonstrate that the transcription factor CBP, which is also implicated in cell proliferation and differentiation, acts as a p53 coactivator and potentiates its ..
  62. ncbi Binding and modulation of p53 by p300/CBP coactivators
    N L Lill
    The Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 387:823-7. 1997
    The adenovirus E1A and SV40 large-T-antigen oncoproteins bind to members of the p300/CBP transcriptional coactivator family. Binding of p300/CBP is implicated in the transforming mechanisms of E1A and T-antigen oncoproteins...
  63. pmc MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
    O M Sobulo
    University of Chicago, Department of Medicine, Section of Hematology Oncology, Chicago, IL 60637 1470, USA
    Proc Natl Acad Sci U S A 94:8732-7. 1997
    ..We show that the MLL gene is fused to the gene that codes for CBP (CREB-binding protein), the protein that binds specifically to the DNA-binding protein CREB (cAMP response element-..
  64. ncbi Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
    H Chen
    Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, La Jolla 92037, USA
    Cell 90:569-80. 1997
    ..ACTR also recruits two other nuclear factors, CBP and P/CAF, and thus plays a central role in creating a multisubunit coactivator complex...
  65. ncbi TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1
    A Takeshita
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 272:27629-34. 1997
    ..These results suggest that TRAM-1 is a coactivator that may exhibit its activity by interacting with subdomains of NRs other than the AF-2 region, in contrast to SRC-1/TIF2...
  66. ncbi Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions
    I Radhakrishnan
    Department of Molecular Biology, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 91:741-52. 1997
    ..activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner...
  67. pmc Factors associated with the mammalian RNA polymerase II holoenzyme
    A S Neish
    Division of Molecular Oncology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nucleic Acids Res 26:847-53. 1998
    ..Earlier experiments have demonstrated that the breast cancer-associated tumor suppressor BRCA1 and the CREB binding protein (CBP) were associated with the holoenzyme complex...
  68. ncbi Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
    P L Puri
    Laboratory of Gene Expression, Fondazione Andrea Cesalpino, Istituto I Clinica Medica, Policlinico Umberto I, University of Rome, La Sapienza, Italy
    Mol Cell 1:35-45. 1997
    PCAF is a histone acetyltransferase that associates with p300/CBP and competes with E1A for access to them...
  69. pmc A human RNA polymerase II complex containing factors that modify chromatin structure
    H Cho
    Howard Hughes Medical Institute, Division of Nucleic Acid Enzymology, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 18:5355-63. 1998
    ..This complex contains the Srb proteins, the Swi-Snf complex, and the histone acetyltransferases CBP and PCAF in addition to RNA polymerase II. Notably, the general transcription factors are absent from this complex...
  70. ncbi The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter
    Y L Chai
    Department of Human Genetics, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    Oncogene 18:263-8. 1999
    ..BRCA1 splice variants BRCA1a (p110) and BRCA1b (p100) associates with CBP/p300 co-activators...
  71. pmc Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling
    V Doucas
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 96:2627-32. 1999
    ..Here, we demonstrate that the cAMP enhancer binding protein (CREB)-binding protein (CBP) associates with PML in vitro and is recruited to the PODs in vivo...
  72. pmc CBP/p300 interact with and function as transcriptional coactivators of BRCA1
    G M Pao
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:1020-5. 2000
    ..We now describe that BRCA1-mediated transactivation is enhanced by p300/CBP (CREB binding protein) and that this effect was suppressed by the adenovirus E1A oncoprotein...
  73. ncbi RT-PCR analysis of the MOZ-CBP and CBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13)
    I Panagopoulos
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 28:415-24. 2000
    ..The t(8;16) fuses the MOZ gene from 8p11 with the CBP (also named CREBBP) gene from 16p13...
  74. pmc CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus
    A von Mikecz
    Junior Research Group of Molecular Cell Biology, Medizinisches Institut für Umwelthygiene, Heinrich Heine Universät Düsseldorf, 40225 Dusseldorf, Germany
    J Cell Biol 150:265-73. 2000
    ..Here we analyzed the nuclear distribution of the transcriptional coactivators CREB-binding protein (CBP)/p300 in situ by confocal laser scanning microscopy, and in vivo complex formation by coimmunoprecipitation...
  75. ncbi Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)
    I Panagopoulos
    Department of Clinical Genetics, University Hospital, SE 221 85 Lund, Sweden
    Hum Mol Genet 10:395-404. 2001
    The CBP gene at 16p13 fuses to MOZ and MLL as a result of the t(8;16)(p11;p13) in acute (myelo)monocytic leukemias (AML M4/M5) and the t(11;16)(q23;p13) in treatment-related AML, respectively...
  76. ncbi Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome
    T Murata
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Hum Mol Genet 10:1071-6. 2001
    CREB-binding protein (CBP) is a transcriptional coactivator that has intrinsic histone acetyltransferase (HAT) activity. CBP is the causative gene of Rubinstein-Taybi syndrome (RTS)...
  77. ncbi Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV
    Soren Impey
    The Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L 474, Portland, OR 97201, USA
    Neuron 34:235-44. 2002
    ..persistent CREB phosphorylation and CaM kinase IV (CaMKIV) responsible for phosphorylating the CREB coactivator, CBP. Ser301 of CBP was identified as a major target of CaMKIV phosphorylation in vitro and in vivo...
  78. pmc Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:3549-61. 2002
    ..Taken together, our results not only reveal the IKK-mediated phosphorylation of SRC-3 to be a regulated event that plays an important role but also substantiate the role of SRC-3 in multiple signaling pathways...
  79. pmc Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1583, USA
    J Virol 76:9724-34. 2002
    ..tumor virus (MMTV) promoter and of the Tat-induced HIV-1 long terminal repeat promoter by directly binding to p300/CBP coactivators...
  80. pmc Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    EMBO J 21:6539-48. 2002
    ..We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, 221 and ..
  81. ncbi Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome
    Eric Kalkhoven
    Department of Molecular Cell Biology, MGC Centre for Biomedical Genetics, Leiden University Medical Centre, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands
    Hum Mol Genet 12:441-50. 2003
    Disruption of one copy of the human CREB binding protein (CBP or CREBBP) gene leads to the Rubinstein-Taybi syndrome (RTS), a developmental disorder characterized by retarded growth and mental functions, broad thumbs, broad big toes and ..
  82. ncbi Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2
    Jose Braganca
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    J Biol Chem 278:16021-9. 2003
    The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2) co-activator...
  83. pmc Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA
    Betty Poon
    Department of Microbiology, David Geffen School of Medicine at UCLA, UCLA AIDS Institute and Jonsson Comprehensive CAncer Center, Los Angeles, California 90095, USA
    J Virol 77:3962-72. 2003
    ..These results attribute a new function to HIV-1 Vpr and implicate Vpr as a critical component in expression from unintegrated HIV-1 DNA...
  84. ncbi Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 15:937-49. 2004
    ..Our results uncovered an additional level of transcriptional regulation whereby specific modulations of SRC-3 phosphorylation allow this coactivator to function as a regulatable integrator for diverse signaling pathways in cells...
  85. ncbi Stat3 dimerization regulated by reversible acetylation of a single lysine residue
    Zheng Long Yuan
    Department of Surgery, Brown University Medical School Rhode Island Hospital, Providence, RI 02903, USA
    Science 307:269-73. 2005
    ....
  86. pmc Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease
    Jeroen H Roelfsema
    Center for Human and Clinical Genetics, Leiden University Medical Center, Sylvius Laboratory, Leiden, The Netherlands
    Am J Hum Genet 76:572-80. 2005
    ..protein is essential for normal development, since inactivation of one allele causes Rubinstein-Taybi syndrome (RSTS)...
  87. pmc Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination
    Young Ho Lee
    Department of Pathology, University of Southern California, 2011 Zonal Avenue, HMR 301, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 102:3611-6. 2005
    ..and retinoid receptors], the histone acetyltransferases cAMP response element binding protein binding protein (CBP) and p300 and the histone methyltransferase coactivator-associated arginine methyltransferase (CARM1) depends on ..
  88. ncbi Minor expression of fascin-1 gene (FSCN1) in NTera2 cells depleted of CREB-binding protein
    Francesca Megiorni
    Department of Experimental Medicine and Pathology, La Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy
    Neurosci Lett 381:169-74. 2005
    CREB-binding protein (CBP) is a transcriptional coactivator whose mutations may cause a generalized perturbation of gene expression. We silenced the CBP gene in NT2 neuronal precursor cells by RNA interference...
  89. ncbi DNA sequencing of CREBBP demonstrates mutations in 56% of patients with Rubinstein-Taybi syndrome (RSTS) and in another patient with incomplete RSTS
    Oliver Bartsch
    Institut fur Humangenetik, Klinikum, Universitat Mainz, 55101, Mainz, Germany
    Hum Genet 117:485-93. 2005
    Rubinstein-Taybi syndrome (RSTS) is a distinct dominant disorder characterized by short stature, typical face, broad angulated thumbs and halluces, and mental retardation...
  90. ncbi Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes
    Sung Yun Jung
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 19:2451-65. 2005
    ..We hope that the electronic availability of these data to the general scientific community will facilitate generation and testing of new hypotheses to further our understanding of nuclear receptor signaling and coactivator functions...
  91. ncbi MOZ-TIF2 alters cofactor recruitment and histone modification at the RARbeta2 promoter: differential effects of MOZ fusion proteins on CBP- and MOZ-dependent activators
    Hilary M Collins
    School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    J Biol Chem 281:17124-33. 2006
    MOZ-TIF2 and MOZ-CBP are leukemogenic fusion proteins associated with therapy-induced acute myeloid leukemia. These proteins are thought to subvert normal gene expression in differentiating hematopoietic progenitor cells...
  92. pmc The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation
    Hina Naeem
    Cancer Research Laboratories, London Regional Cancer Program, London, Ontario, Canada N6A 4L6
    Mol Cell Biol 27:120-34. 2007
    ..hormone receptors and facilitates transcription by directly recruiting accessory factors such as acetyltransferase CBP/p300 and the coactivator arginine methyltransferase CARM1...
  93. ncbi p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint
    Daniel Stauffer
    Department of Biochemistry, Oregon Health and Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 282:9678-87. 2007
    The highly related acetyltransferases, p300 and CREB-binding protein (CBP) are coactivators of signal-responsive transcriptional activation...
  94. pmc Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB
    Wei Chien Huang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei 10018, Taiwan Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 26:75-87. 2007
    b>CBP plays a central role in coordinating and integrating multiple signaling pathways. Competition between NF-kappaB and p53 for CBP is a crucial determinant of whether a cell proliferates or undergoes apoptosis...
  95. pmc Acetylation is indispensable for p53 activation
    Yi Tang
    Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 133:612-26. 2008
    ..Our study identifies p53 acetylation as an indispensable event that destabilizes the p53-Mdm2 interaction and enables the p53-mediated stress response...
  96. pmc CBP/p300-mediated acetylation of histone H3 on lysine 56
    Chandrima Das
    Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, PO Box 6511, Aurora Colorado 80045, USA
    Nature 459:113-7. 2009
    ..Here we demonstrate that the histone acetyl transferase CBP (also known as Nejire) in flies and CBP and p300 (Ep300) in humans acetylate H3K56, whereas Drosophila Sir2 and ..
  97. pmc CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53
    Dingding Shi
    Department of Cancer Biology, University of Massachusetts Medical School and University of Massachusetts Memorial Cancer Center, 364 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:16275-80. 2009
    p300 and CREB-binding protein (CBP) act as multifunctional regulators of p53 via acetylase and polyubiquitin ligase (E4) activities...
  98. pmc Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells
    Irina Ianculescu
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089 9176, USA
    J Biol Chem 287:4000-13. 2012
    The protein acetyltransferases p300 and cAMP response element-binding protein binding protein (CBP) are homologous, ubiquitously expressed proteins that interact with hundreds of proteins involved in transcriptional regulation and are ..
  99. ncbi Transcription factor-specific requirements for coactivators and their acetyltransferase functions
    E Korzus
    Howard Hughes Medical Institute, University of California San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093 0648, USA
    Science 279:703-7. 1998
    ..STAT-1)-functionally require distinct components of the coactivator complex, including CREB-binding protein (CBP/p300), nuclear receptor coactivators (NCoAs), and p300/CBP-associated factor (p/CAF), based on their platform or ..
  100. ncbi Synergistic activation of the prolactin promoter by vitamin D receptor and GHF-1: role of the coactivators, CREB-binding protein and steroid hormone receptor coactivator-1 (SRC-1)
    A I Castillo
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Mol Endocrinol 13:1141-54. 1999
    ..Indeed, expression of the coactivators, steroid hormone receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), significantly enhances the stimulatory effect of vitamin D mediated by the wild-type VDR but not by the AF2 ..
  101. ncbi Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription
    Marc Tini
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 9:265-77. 2002
    ..We report that TDG associates with transcriptional coactivators CBP and p300 and that the resulting complexes are competent for both the excision step of repair and histone ..

Research Grants71

  1. RAJESH K ANEJA; Fiscal Year: 2016
    ..HAT) activity of p300 and a closely related protein, cAMP response element-binding protein (CREB)-binding protein (CBP);3) PARP-1 inhibits LPS-mediated HMGB1 gene transcription...
  2. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
    ..factors like CREB, but also transcriptional coactivators, such as the paralogous factors CREB- binding protein (CBP) and p300...
  3. Role of Cited2 in Hematopoiesis
    Yu Chung Yang; Fiscal Year: 2011
    Cited2 [CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2] is one of the founding members of a new family of transcriptional modulators...
  4. Histone Acetylation and Insulin Gene Expression
    Sabire Ozcan; Fiscal Year: 2010
    ..of Pdx-1 important for Pdx-1 activity and/or DNA binding? 2) What role do the histone acetyltransferases p300/CBP and GCN5/PCAF play in glucose regulation of insulin gene expression? 3) Do the beta-cell specific transcription ..
  5. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
    ..We detected IFNR2 acetylation by recruiting tumor suppressor-like transcription cofactor CREB-binding protein (CBP) or its homologous p300. Acetylated IFNR2 can then recruit IRF9...
  6. Coregulatory factor modulation of CREB activity
    ROLAND P KWOK; Fiscal Year: 2010
    ..Our preliminary data show that CBP, the co-activator of the CRE-binding protein CREB, forms a complex with co-repressor histone deacetylases (HDAC)...
  7. Zhonghui Guan; Fiscal Year: 2016
    ..As members of the ATF family bind the KIX domain of CBP, which acetylates histones at gene promoters and regulates gene transcription, we tested the hypothesis that CBP ..
  8. John S Davis; Fiscal Year: 2014
    ..To determine whether 2-catenin interaction with LRH-1 recruits additional transcriptional co-activators, such as CBP (CREB-binding protein), during the regulation of StAR expression and progesterone synthesis...
  9. John H Byrne; Fiscal Year: 2015
    ..This project will advance the understanding of basic memory mechanisms, which will lead to better learning paradigms and help identify molecular targets for pharmacological treatments of brain disorders. ..
  10. Chemical Modulators for p53 Functions in Transcriptional Regulation
    SYED S MUJTABA; Fiscal Year: 2012
    ..Our study revealed that p53 recruitment of the co-activator CBP (CREB binding protein) requires association of the conserved bromodomain of CBP (CBP BRD) with p53 at acetylated Iysine 382 (..
  11. CBP Bromodomain Antagonists Block Androgen Receptor in Prostate Cancer
    SYED S MUJTABA; Fiscal Year: 2010
    ..Although it is known that CBP/p300 (CREB binding protein) mediated lysine acetylation of AR (ARKac) plays a vital role in AR activation and control of downstream ..
  12. Mechanisms of p53 activation in tumorsuppression
    Wei Gu; Fiscal Year: 2012
    ..In our early studies, we found that histone acetyltransferase CBP/p300 promotes p53-dependent transcription by directly acetylating lysine residues in the C-terminal region of p53...
  13. Regulation of transcription by chromatin modifying enzymes in extinction learning
    Ruth M Barrett; Fiscal Year: 2010
    ..The first aim of this research proposal is to determine the role of CREB-binding protein (CBP), a histone acetyltransferase known to be involved in associative learning, in the acquisition of extinction...
  14. Ronen Marmorstein; Fiscal Year: 2016
    ..HATs fall into at least four families based on sequence conservation, Gcn5/PCAF, MYST, p300/CBP and Rtt109...
  15. Subbiah Pugazhenthi; Fiscal Year: 2016
    ..c-jun, STAT-1 and NF-?B, the transcriptions factors that compete with CREB for the limited pool of coactivators, CBP and p300. (iii) Inflammation can direct CREB to pathways other than those needed for neuronal function...
  16. Gerhard Wagner; Fiscal Year: 2016
    ..by SREBPs, demonstrating a central role for the MED15 subunit of the Mediator co-activator complex and the CBP/p300 acetyltransferases...
  17. Peilin Li; Fiscal Year: 2014
    ..IRF-1 also can interact with HAT, such as p300/CBP (cAMP-responsive-element-binding factor (CREB)-binding protein) to evoke HIV transcription from the LTR in the ..
  18. Protective role of creb-binding protein in maturation and aging
    Charles V Mobbs; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): We propose the rapid decline of CBP and associated histone acetyltransferase (HAT) activity during maturation serves the function of ending a series of critical periods of organization, especially in ..
  19. Chromatin Remodeling and Memory Storage
    MARCELO ANDRES WOOD; Fiscal Year: 2012
    ..For example, our previous research demonstrated that CREB-binding protein (CBP), a potent HAT and transcriptional coactivator, is critical for long-lasting forms of synaptic plasticity (the ..
  20. Epigenetic Regulation of Hippocampal Synaptic Plasticity
    MORGAN STUART BRIDI; Fiscal Year: 2013
    ..acetylation by the cyclic AMP response element binding protein (CREB) and the co-activator CREB-binding protein (CBP), are also strong candidates for negative regulation by the Sin3a/HDAC complex...
  21. In vivo Analysis of ATM-Regulated Pathways
    RANDAL SCOT TIBBETTS; Fiscal Year: 2011
    ..of CREB by ATM and CK1/CK2 inhibits the interaction between CREB and its coactivator, CREB-binding protein (CBP) suggesting that the ATM pathway may repress CREB transcriptional functions in response to DNA damage...
  22. ESE 1 a novel transcriptional regulator of cartilage remodeling
    MARY GOLDRING; Fiscal Year: 2009
    ..type II collagen gene (COL2A1) expression by binding to the COL2A1 promoter and by interacting with Sox9 and CBP. Our preliminary data show that ESE-1 also increases matrix metalloproteinase (MMP)-13, a key collagen-degrading ..
  23. Transcriptional Regulation by the HTLV-1 Tax Protein
    Jennifer K Nyborg; Fiscal Year: 2013
    ..Together, this complex recruits the cellular coactivators CBP/p300, which is a fundamental step in transcriptional activation of HTLV-1...
  24. Gourisankar Ghosh; Fiscal Year: 2016
    ..In aim 1 experiments are designed to investigate the mechanisms of transcriptional control by the RelA:CBP/p300 complex...
  25. Wen Wei Tsai; Fiscal Year: 2014
    ..In specific aim 1, the role of PRMT5 in methylating CREB and modulating the interaction between CREB and CRTC2 or CBP will be explored. CREB arginine residues that undergo methylation will be identified...
  26. Activities of HHV-8 vIRF-1 in Virus Biology
    John Nicholas; Fiscal Year: 2012
    ..Cellular proteins targeted for inhibition by vIRF-1 include p53, ATM, GRIM19, Smad transcription factors, and p300/CBP transcriptional co-activators required for IRF-?mediated responses...
  27. Michael Kahn; Fiscal Year: 2016
    ..modulate interactions between b-catenin and either of its transcriptional coactivators, p300 or CREB binding protein (CBP), have led us to propose a model to explain dichotomous activities of Wnt/[unreadable]-catenin ..
  28. Folding Mechanism of Intrinsically Disordered Proteins: The pKID/KIX complex
    ROBERT CULIK; Fiscal Year: 2013
    ..the pKID/KIX complex, which are two domains isolated from the transcription factor CREB and its activator CREB binding protein (CBP)...
  29. Charles G Mullighan; Fiscal Year: 2016
    ..identified lesions in the two genes encoding the KAT3 family of histone acetyltransferases, CREB-binding protein (CBP, CREBBP) and EP300 (p300). ALL is the most common childhood cancer and the focus of this proposal...
  30. Regulation of NFkappaB activity by the Estrogen Receptor
    Kendall W Nettles; Fiscal Year: 2012
    ..This hypothesis will be pursued in the following Specific Aims: SPECIFIC AIM 1. To investigate the importance of CBP and Grip1 in the molecular interactions required for ER-mediated suppression of NF-B, we will measure their ..
  31. Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
    Fatah Kashanchi; Fiscal Year: 2010
    ..in HIV-1 infected cells by binding the trans-activation response region (TAR) and recruiting cdk9/cyclin T1, p300/CBP, SWI/SNF, and RNA Polymerase II. Sustained HIV-1 replication further progresses infected T cells towards AIDS...
  32. Wei Gu; Fiscal Year: 2016
    ..In our early studies, we found that CBP/p300 promotes p53-dependent transcription by directly acetylating lysine residues in the C-terminal region of p53 (..
  33. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..Phosphorylated CREB recruits the nuclear co-activators CREB binding protein (CBP), and the related protein p300, which stimulate gene transcription through histone deacetylase ..
  34. SRCAP Regulation of CREB and GR-mediated Transcription
    John Chrivia; Fiscal Year: 2005
    CREB-binding protein (CBP) functions as a coactivator for many transcription factors and is able to respond to extracellular signals to specifically regulate gene expression...
  35. Marshall B Elam; Fiscal Year: 2014
    ..i) n-3 PUFA modulate the interaction of LXR1 with transcription factors (Sp1, SREBP- 1c), co-activators (SRC-1, CBP), and co-repressors (NcoR, SMRT, HDAC), (ii) n-3 PUFA alter binding and/or metabolism of endogenous ligands of LXR1 ..
  36. Transcription Programming in Cardiac Growth
    NANETTE HAHR BISHOPRIC; Fiscal Year: 2012
    ..We will carry out cardiac-specific deletion of p300 and CBP to determine whether these proteins have distinct or myocyte-autonomous roles in hypertrophy...
  37. Genome-wide protein-DNA interactions responding to chronic opioid treatment
    Yulong Chen; Fiscal Year: 2012
    ..We will establish this method to analyze genome-wide CBP/p300-NF-:B/p65-DNA interactions in mu and delta opioid receptor-expressing cells after acute and chronic morphine (..
  38. Opposing and complementary roles of KLF1 and KLF2 in erythropoiesis
    Joyce A Lloyd; Fiscal Year: 2012
    ..and knockout (KO) mouse models will be used to determine if KLF1 and KLF2 are required for recruitment of BRG1 and CBP/p300 chromatin remodeling complexes to the [unreadable]-globin LCR and promoters...
  39. Mary B Goldring; Fiscal Year: 2014
    ..type II collagen gene (COL2A1) expression by binding to the COL2A1 promoter and interacting with Sox9 and CBP and that ESE-1 immunostaining is increased in superficial and midzone regions of cartilage from patients with ..
  40. ISABELLE MICHELE LEMASSON; Fiscal Year: 2014
    ..We found that HBZ also binds directly to the cellular coactivators p300 and CBP, which is mediated through regions of the viral protein outside its bZIP domain...
  41. KLF2 as a novel regular for monocyte activation and function
    Hiranmoy Das; Fiscal Year: 2012
    ..activity of both NF-kB and activator protein-1 in part by means of recruitment of transcriptional coactivator p300/CBP-associated factor, PCAF. These observations implicate KLF2 as a novel negative regulator of monocytic activation...
  42. Functions of an E1A-Associated Cellular Protein
    Bayar Thimmapaya; Fiscal Year: 2010
    ..These include p400, p300 and the highly related CBP, Retinoblastoma protein (Rb), and two Rb related proteins p107 and p130...
  43. Long-range function of the ERV-9 LTR in regulating globin gene switching
    DOROTHY Y TUAN; Fiscal Year: 2012
    ..We subsequently found that in the [unreadable]LTR Tg mice, LTR deletion lowered the levels of NF-Y, GATA-2 and CBP on the [unreadable]-globin promoter but increased the levels of these factors on the [unreadable]-globin promoter ..
  44. Human autism genetics and activity dependent gene activation
    Christopher A Walsh; Fiscal Year: 2010
    ..g. MEF2, c-fos, SR, CREB, CBP, etc...
  45. Edward E Morrisey; Fiscal Year: 2015
    ..Hdac function is counterbalanced by acetylatransferases including p300 and CBP. We have begun to explore the importance of Hdac mediated chromatin remodeling complexes by inactivating Hdac1 and ..
  46. Tae Hee Lee; Fiscal Year: 2015
    ..Results from the project will provide a novel and unique basis for the development of diagnoses and treatments of the diseases and disorders originated from abnormal DNA methylation and defective histone acetylation. ..
  47. E1A Oncoprotein Induced Deregulation of Replication Origin Firing
    Bayar Thimmapaya; Fiscal Year: 2012
    ..In cooperation with cellular activated ras or virus encoded E1B19K or 55K proteins and by binding to p300/CBP and Rb family proteins, E1A can transform rodent cells...
  48. Hans Tomas Bjornsson; Fiscal Year: 2016
    ..H3K4 trimethylation and histone acetylation);(b) exploring whether the double heterozygote state (Mll2+/- and Cbp+/-) increases the severity of the abnormalities found in Mll2 (+/-);(c) testing the hypothesis that the gene ..
  49. MARCELO ANDRES WOOD; Fiscal Year: 2016
    ..Specific Aim 3, we will examine the effects of inhibiting a chromatin modifying enzyme called CREB-binding protein (CBP), which relaxes chromatin structure, through genetic mutations and focal deletions of CBP, thereby inhibiting ..
  50. Roles of Zinc Transporter ZIP4 (SLC39A4) in Pancreatic Cancer Pathogenesis
    Min Li; Fiscal Year: 2010
    ..We will also determine whether overexpression of ZIP4 a) upregulates the transcription of IL-6 through CBP/CREB transcription factors, and b) affects PC cell proliferation and tumor progression via the IL-6/STAT3 pathway...
  51. Activator-Targeted Subunits of the ARC/Mediator
    Anders M Naar; Fiscal Year: 2010
    ..examine how SREBPs interact molecularly and functionally with the putative ARC105 KIX domain in comparison with the CBP and p300 KIX domains...
  52. The role of PRR7 in gene transcription and synaptic function
    DANA OR SAVARIEGO; Fiscal Year: 2013
    ..syndrome result from mutations in the transcription factor MeCP2 and the transcription co-activator CBP, respectively...
  53. Regulation of NF-kappaB transactivation function
    BRIAN ASHBURNER; Fiscal Year: 2009
    ..These coactivators include the CREB-binding protein (CBP) and its homolog, p300;the p300/CBP associated factor (P/CAF);and members of the steroid receptor coactivator (p160/..
  54. ANDREW JESS DANNENBERG; Fiscal Year: 2015
    ..PGE2, BRCA1, histone acetylation and aromatase induction, based on our novel data implicating BRCA1, Sirt-1 and CBP/p300 in PGE2-mediated aromatase induction...
  55. Mitochondrial-localized activities of HHV-8 vIRF-1
    John Nicholas; Fiscal Year: 2013
    ..Cellular proteins targeted for inhibition by vIRF-1 include p53, ATM, GRIM19, Smad transcription factors, and p300/CBP transcriptional co-activators required for IRF-mediated responses...
  56. Cheng Ming Chiang; Fiscal Year: 2016
    ..system that we have developed to define the role of cellular chromatin-modifying enzymes, including p300 and CBP histone acetyltransferases (HATs), in AP-1-dependent activation of HPV chromatin transcription...
  57. Brain epigenetic mechanisms in alcohol dependence
    SUBHASH PANDEY; Fiscal Year: 2009
    ..element binding (p-CREB) regulates neuronal plasticity via recruitment of the HAT associated with CREB binding protein (CBP) to activate gene transcription...
  58. REGULATION OF GROWTH FACTORS AND EMBRYOGENESIS
    ARNOLD RIZZINO; Fiscal Year: 2005
    ..its effects? Recent studies argue that Sox-2 and Oct-3 can mediate their effects through the co-activators p300 and CBP (p300/CBP)...
  59. Nicola C Partridge; Fiscal Year: 2016
    ..In the nucleus, Runx2 then recruits the histone acetyl transferases (HATs), p300 and p300/CBP associated factor (PCAF)...
  60. Ming Ming Zhou; Fiscal Year: 2014
    ..Increase in FosB promoter acetylation has been shown to be dependant on CBP (CREB binding protein) dependant histone acetyl transferase (HAT) activity...
  61. Role of Cited2 in lens development and hyaloid vascular regression
    Yu Chung Yang; Fiscal Year: 2010
    Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a founding member of a new family of transcriptional modulators...
  62. EBNA3C and tumor supressors
    Erle S Robertson; Fiscal Year: 2010
    ..We will investigate the recruitment of acetylases including p300 and CBP by EBNA3C to determine its ability to modify p53 through acetylation and whether or not phosphorylation is critical ..
  63. MECHANISMS OF PATHOGENESIS BY THE MYB ONCOPROTEIN
    Richard Press; Fiscal Year: 2000
    ..2) by characterizing the recently-discovered binding interaction between myb and the transcriptional co-activator CBP, and 3) by determining the normal and pathologic functional consequences of the myb-CBP binding interaction...
  64. CONTROL OF P53 TUMOR SUPPRESSOR BY CBP/P300
    Tso Pang Yao; Fiscal Year: 2005
    DESCRIPTION (from the application): The long-term objective of this proposal is to elucidate the function of CBP and its family member p300 in cellular growth and oncogenesis...
  65. Role of Cited2 in Lung Development
    Yu Chung Yang; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cited2 [CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2] is one of the founding members of a new family of transcriptional activators...
  66. Analysis of craniofacial transcription factor and coactivator functional networks
    Paul Brindle; Fiscal Year: 2009
    ..CREB-binding protein (CBP) and the closely related p300 (CBP/p300 collectively) are transcriptional coactivators that interact physically or ..
  67. TRANSCRIPTIONAL COACTIVATORS IN HEMATOPOIESIS
    Paul Brindle; Fiscal Year: 2005
    ..CREB-binding protein (CBP) and the highly related p300, are large multi-domain nuclear phosphoprotein coactivators that functionally and ..
  68. In Vivo Analysis of a Transcriptional Coactivator Domain
    Paul Brindle; Fiscal Year: 2004
    ..and enhancers, and stimulate transcription by binding the transcriptional coactivators CREB-binding protein (CBP) and its paralog p300...
  69. Molecular Mechanisms of Long-Term Memory Storage
    EDWIN TED G ABEL; Fiscal Year: 2010
    ..transcription factors like CREB, but also transcriptional coactivators, such as CREB- binding protein (CBP)...
  70. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
    ..Rtt109 is very distantly related the mammalian p300/CBP HAT enzyme, but compounds that inhibit p300/CBP do not inhibit Rtt109...
  71. CONTROL OF TRANSLATION BY POLIOVIRUS PROTEINASE
    Richard Lloyd; Fiscal Year: 1999
    ..that poliovirus infection of HeLa cells results in inactivation of an initiation factor, the cap binding protein (CBP) complex, which its believed to facilitate binding of capped mRNAs to ribosomal 40S subunits...