caveolin-1

Summary

Gene Symbol: caveolin-1
Description: caveolin 1
Alias: BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21, caveolin-1, caveolin 1, caveolae protein, 22kDa, cell growth-inhibiting protein 32
Species: human

Top Publications

  1. ncbi Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
  2. doi Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells
    Hideki Yamaguchi
    Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Cancer Res 69:8594-602. 2009
  3. ncbi Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center and the Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 276:6727-38. 2001
  4. pmc High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients
    Mariantonia Logozzi
    Unit of Antitumor Drugs, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 4:e5219. 2009
  5. pmc Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers
    Agnieszka K Witkiewicz
    Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1794-809. 2011
  6. ncbi Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1
    J P Gratton
    Department of Pharmacology and Program of Molecular Cardiobiology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 275:22268-72. 2000
  7. doi Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy
    C A Kim
    Department of Pediatrics, Instituto da Criança, University of Sao Paulo, 05403 900 Sao Paulo, Brazil
    J Clin Endocrinol Metab 93:1129-34. 2008
  8. ncbi The caveolin-1 connection to cell death and survival
    A F G Quest
    Laboratorio de Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula CEMC, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Curr Mol Med 13:266-81. 2013
  9. pmc Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1
    Min Lin
    Division of Hematology Oncology, Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Mol Cancer 4:21. 2005
  10. ncbi Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt
    Madanamohan Boyanapalli
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Biochem Biophys Res Commun 340:1200-8. 2006

Research Grants

  1. Exercise as a novel strategy to target methamphetamine-induced cerebrovascular to
    Michal Toborek; Fiscal Year: 2013
  2. Structure and Function of Membrane Rafts
    Deborah Brown; Fiscal Year: 2009
  3. Implications of caveolae in Tat signaling and integrity of brain endothelium
    Min Seon Park; Fiscal Year: 2012
  4. David M Roth; Fiscal Year: 2016
  5. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2013
  6. Timothy J Kamp; Fiscal Year: 2016
  7. David M Roth; Fiscal Year: 2016
  8. Kerney Jebrell Glover; Fiscal Year: 2016
  9. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2010
  10. William C Sessa; Fiscal Year: 2016

Detail Information

Publications341 found, 100 shown here

  1. ncbi Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
    ..We propose that EGF-induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis...
  2. doi Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells
    Hideki Yamaguchi
    Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Cancer Res 69:8594-602. 2009
    ..These results indicate that invadopodia are the sites where enrichment and trafficking of lipid rafts occur and that Cav-1 is an essential regulator of MT1-MMP function and invadopodia-mediated breast cancer cell invasion...
  3. ncbi Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center and the Departments of Medicine and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 276:6727-38. 2001
    ..We localize the Type I TGF-beta receptor interaction to the scaffolding domain of Cav-1 and show that it occurs in a physiologically relevant time frame, acting to rapidly dampen signaling initiated by the TGF-beta receptor complex...
  4. pmc High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients
    Mariantonia Logozzi
    Unit of Antitumor Drugs, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 4:e5219. 2009
    ..Human tumor-derived exosomes are involved in malignant progression and we evaluated the presence of exosomes in plasma of melanoma patients as a potential tool for cancer screening and follow-up...
  5. pmc Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers
    Agnieszka K Witkiewicz
    Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1794-809. 2011
    ....
  6. ncbi Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1
    J P Gratton
    Department of Pharmacology and Program of Molecular Cardiobiology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Biol Chem 275:22268-72. 2000
    ..Collectively, our results show that the actions of CaM on eNOS dissociation from caveolin are facilitated in the presence of hsp90...
  7. doi Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy
    C A Kim
    Department of Pediatrics, Instituto da Criança, University of Sao Paulo, 05403 900 Sao Paulo, Brazil
    J Clin Endocrinol Metab 93:1129-34. 2008
    ..In most reported cases, BSCL is due to alterations in either seipin, of unknown function, or 1-acylglycerol-3-phosphate acyltransferase-beta (AGPAT2), which catalyzes the formation of phosphatidic acid...
  8. ncbi The caveolin-1 connection to cell death and survival
    A F G Quest
    Laboratorio de Comunicaciones Celulares, Centro de Estudios Moleculares de la Célula CEMC, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Curr Mol Med 13:266-81. 2013
    ..Here, we will focus on discussing how Caveolin-1 modulates cell death and survival pathways and how this may contribute to a better understanding of the ambiguous role this protein plays in cancer...
  9. pmc Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1
    Min Lin
    Division of Hematology Oncology, Department of Internal Medicine, The University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Mol Cancer 4:21. 2005
    ..RhoC GTPase is overexpressed in aggressive cancers that metastasize and is the predominant GTPase in PC. Like several GTPases, RhoC contains a putative cav-1 binding motif...
  10. ncbi Neurofibromin binds to caveolin-1 and regulates ras, FAK, and Akt
    Madanamohan Boyanapalli
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Biochem Biophys Res Commun 340:1200-8. 2006
    ..These novel findings provide insight into possible signaling mechanisms of Nf1 and suggest that together Nf1 and Cav-1 may coordinately regulate cell growth and differentiation...
  11. ncbi Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1
    Kei Ohnuma
    Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 282:10117-31. 2007
    ..Taken together, our findings provide novel insights into the regulation of T-cell costimulation via the CD26 molecule...
  12. pmc Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation
    Chao Chi Ho
    Department of Pathology, National Taiwan University Hospital, and National Taiwan University College of Medicine, Taipei, Taiwan
    Am J Pathol 161:1647-56. 2002
    ..We further revealed that up-regulated caveolin-1 in CL cells is necessary for mediating filopodia formation, which may enhance the invasive ability of lung adenocarcinoma cells...
  13. ncbi Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma
    Nijiro Nohata
    Department of Functional Genomics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Oncol 38:209-17. 2011
    ..Therefore, CAV1 functions as an oncogene in HNSCC. The identification of tumor suppressive miRNAs and their target genes could provide new insights into potential mechanism of HNSCC carcinogenesis...
  14. pmc EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1
    Miguel Sáinz-Jaspeado
    Sarcoma Research Group, Laboratori d Oncologia Molecular, Institut d Investigació Biomèdica de Bellvitge IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    PLoS ONE 8:e71449. 2013
    ....
  15. pmc Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
    Xiao Mei Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 203:2895-906. 2006
    ..This study indicates a pivotal role for cav-1 in ECM regulation and suggests a novel therapeutic target for patients with pulmonary fibrosis...
  16. pmc Caveolin-1 suppresses human immunodeficiency virus-1 replication by inhibiting acetylation of NF-κB
    Glenn E Simmons
    Department of Microbiology and Immunology, Meharry Medical College, Nashville, TN 37208, USA
    Virology 432:110-9. 2012
    ..Since hypoacetylated p65 has been shown to inhibit transcription, we conclude that caveolin-1 inhibits HIV-1 transcription through a NF-κB-dependent mechanism...
  17. ncbi Effects of vascular endothelial growth factor on the lymphocyte-endothelium interactions: identification of caveolin-1 and nitric oxide as control points of endothelial cell anergy
    Caroline Bouzin
    Université Catholique de Louvain Medical School, Unit of Pharmacology and Therapeutics, Brussels, Belgium
    J Immunol 178:1505-11. 2007
    ..In conclusion, this study provides new insights on the mechanisms leading to the tumor EC anergy vs immune cells and opens new perspectives for the use of antiangiogenic strategies as adjuvant approaches to cancer immunotherapy...
  18. doi Annexin A6-induced inhibition of cytoplasmic phospholipase A2 is linked to caveolin-1 export from the Golgi
    Laia Cubells
    Departament de Biologia Cellular, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    J Biol Chem 283:10174-83. 2008
    ..These findings indicate that AnxA6 interferes with caveolin transport through the inhibition of cPLA(2)...
  19. doi Caveolin-1 increases basal and TGF-beta1-induced expression of type I procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblasts
    Sangmin Kim
    Department of Dermatology, Seoul National University College of Medicine, Republic of Korea
    Cell Signal 20:1313-9. 2008
    ....
  20. pmc Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells
    Alina Macovei
    Institute of Biochemistry, Splaiul Independentei, 296, Bucharest 77700, Romania
    J Virol 84:243-53. 2010
    ..Chemical inhibitors that specifically inhibit clathrin-mediated endocytosis had no effect on HBV infection. We concluded that HBV requires a Cav-1-mediated entry pathway to initiate productive infection in HepaRG cells...
  21. pmc Caveolin-1 modulates HIV-1 envelope-induced bystander apoptosis through gp41
    Xiao Mei Wang
    Department of Infectious Disease and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
    J Virol 84:6515-26. 2010
    ..Our studies shed new light on the potential role of Cav-1 in limiting HIV pathogenesis and the development of a novel therapeutic strategy in treating HIV-1-infected patients...
  22. pmc PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling
    Wen Huang
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, Kentucky, USA
    FASEB J 25:3979-88. 2011
    ..Overall, our results indicate that ERK1/2, Akt, and cav-1 are involved in the regulatory mechanisms of PPAR-mediated protection against HIV-1-induced MMP-9 expression in brain endothelial cells...
  23. pmc A role for caveolin-1 in desmoglein binding and desmosome dynamics
    D Brennan
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Oncogene 31:1636-48. 2012
    ....
  24. pmc Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol
    Lyne Labrecque
    Centre de cancérologie Charles Bruneau, Hopital Sainte Justine, Montreal, Quebec, Canada H3T 1C5
    Mol Biol Cell 14:334-47. 2003
    ..Overall, these results suggest that caveolin-1 plays multiple roles in the VEGF-induced signaling cascade...
  25. ncbi Caveolin-1 expression enhances endothelial capillary tubule formation
    Jun Liu
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 277:10661-8. 2002
    ....
  26. doi Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis
    Edith Yuk Ting Tse
    Department of Pathology, The University of Hong Kong, Hong Kong
    J Pathol 226:645-53. 2012
    ..The definitive role of Cav1 in promoting HCC tumourigenesis was demonstrated, and we have shown for the first time in a mouse model that Cav1 promotes HCC metastasis...
  27. ncbi Caveolin-1 regulates store-operated Ca2+ influx by binding of its scaffolding domain to transient receptor potential channel-1 in endothelial cells
    Angela M Kwiatek
    Department of Pharmacology M C868, College of Medicine, University of Illinois at Chicago, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Mol Pharmacol 70:1174-83. 2006
    ..We identified the interaction between biotin-labeled AP-TRPC1 C terminus peptide and caveolin-1. Thus, these results demonstrate a crucial role of caveolin-1 scaffolding domain interaction with TRPC1 in regulating Ca2+ influx via SOC...
  28. ncbi Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation
    M L Lu
    Division of Urologic Surgery, Department of Surgery, Renal Division, Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:13442-51. 2001
    ..Using a mammalian two-hybrid assay system, we determine that the NH(2) terminus region of caveolin-1 is responsible for the interaction with both the NH(2)-terminal domain and the ligand-binding domain of AR...
  29. pmc FoxO3a (Forkhead Box O3a) deficiency protects Idiopathic Pulmonary Fibrosis (IPF) fibroblasts from type I polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas
    Richard Seonghun Nho
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS ONE 8:e61017. 2013
    ..Our data indicate that the pathologically altered PTEN/Akt axis inactivates FoxO3a down-regulating cav-1 and Fas expression. This confers IPF fibroblasts with an apoptosis-resistant phenotype and may be responsible for IPF progression...
  30. pmc Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas
    K Wiechen
    Institute of Pathology, Universitatsklinikum Charite, Medizinische Fakultat der Humboldt Universitat Berlin, Schumannstr 20 21, 10117 Berlin, Germany
    Am J Pathol 158:833-9. 2001
    ..In addition, re-expression of caveolin-1 in HT-1080 fibrosarcoma cells potently inhibited colony formation. From these we conclude that caveolin-1 is likely to act as a tumor suppressor gene in human sarcomas...
  31. ncbi Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation
    Yong Nyun Kim
    Department of Biomolecular Chemistry, University of Wisconsin, Madison 53706, USA
    Exp Cell Res 280:134-47. 2002
    ..These observations support a role for caveolin tyrosine phosphorylation in the profile of cellular responses by which Src potentiates cancer progression following EGF receptor overexpression...
  32. ncbi Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle
    Reinoud Gosens
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Am J Physiol Lung Cell Mol Physiol 291:L523-34. 2006
    ..As such, caveolae and caveolin-1 coordinate PDGF receptor signaling, leading to myocyte proliferation, and inhibit constitutive activity of p42/p44 MAPK to sustain cell quiescence...
  33. ncbi Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma
    Yuichi Hirasawa
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Oncology 71:77-85. 2006
    ....
  34. pmc Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells
    Elena V Vassilieva
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Whitehead Research Building, 615 Michael Street, Atlanta, Georgia 30322, USA
    Biochem Biophys Res Commun 379:460-5. 2009
    ..Our data suggest that flotillin-1 regulates caveolin-1 level by preventing its lysosomal degradation in intestinal epithelial cells...
  35. pmc Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis
    Hong Xia
    Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Am J Pathol 176:2626-37. 2010
    ..This creates a membrane microenvironment depleted of inhibitory phosphatase activity, facilitating the aberrant activation PI3K/Akt and pathological proliferation...
  36. pmc Caveolin 1 inhibits HIV replication by transcriptional repression mediated through NF-κB
    Xiao Mei Wang
    Department of Infectious Disease and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
    J Virol 85:5483-93. 2011
    b>Caveolin 1 (Cav-1), the scaffold protein of a specific membrane lipid raft called caveolae, has been reported to suppress HIV-1 replication. However, the mechanism by which Cav-1 inhibits HIV replication remains unclear...
  37. pmc Deletion of caveolin-1 protects hyperoxia-induced apoptosis via survivin-mediated pathways
    Meng Zhang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, MUH 628NW, 3459 5th Ave, Pittsburgh, PA 15213, USA
    Am J Physiol Lung Cell Mol Physiol 297:L945-53. 2009
    ..We also demonstrate that deletion of cav-1 protects hyperoxia-induced apoptosis via modulation of survivin expression...
  38. pmc Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence
    Daniela Volonte
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    EMBO Rep 10:1334-40. 2009
    ..We show that caveolin 1, the structural protein component of caveolae, is a TrxR1-binding protein by demonstrating that the scaffolding ..
  39. pmc Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5
    Yukie Yamaguchi
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cell Mol Med 15:957-69. 2011
    ....
  40. doi Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival
    Karen N Wu
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:4250-5. 2011
    ..0001). In conclusion, high expression of stromal Cav-1 correlates with longer survival in malignant melanoma metastases, and high expression of Cav-1 in melanoma cells correlates with longer survival in primary malignant melanoma...
  41. ncbi Promoter CpG methylation of caveolin-1 in sporadic colorectal cancer
    Shyr Yi Lin
    Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    Anticancer Res 24:1645-50. 2004
    ..Caveolin-1 has been shown to be down-regulated in human colon cancer and involved in colon tumorigenesis. We investigated the mechanism...
  42. ncbi Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome
    Agnieszka K Witkiewicz
    Department of Pathology, Jefferson Center for Pancreatic, Biliary and Related Cancers, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cell Cycle 7:3021-5. 2008
    ..Thus, Cav-1 and FASN may functionally cooperate in the process of pancreatic tumorigenesis, and as such, may be good candidate prognostic markers and targets for therapeutic intervention...
  43. doi Human melanoma cells express FGFR/Src/Rho signaling that entails an adhesion-independent caveolin-1 membrane association
    Katia Fecchi
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Int J Cancer 130:1273-83. 2012
    ....
  44. ncbi Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines
    J A Engelman
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    FEBS Lett 448:221-30. 1999
    ..In conclusion, our current studies provide a systematic basis for diagnostically evaluating the potential deletion, mutation, or methylation of the caveolin genes in a variety of human tumors...
  45. ncbi Caveolin-1 in meningiomas: expression and clinico-pathological correlations
    V Barresi
    Dipartimento di Patologia Umana, Universita degli Studi di Messina, Messina, Italy
    Acta Neuropathol 112:617-26. 2006
    ..Multivariate analysis indicated that only Ki-67 was an independent prognostic factor. Increased immunoexpression of the Cav-1 seems to be associated with the biological aggressiveness of meningiomas, reflecting a worse prognosis...
  46. ncbi Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation
    Victoria Catalan
    Metabolic Research Laboratory, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Spain
    Clin Endocrinol (Oxf) 68:213-9. 2008
    ....
  47. doi Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway
    Micha Nethe
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 123:1948-58. 2010
    ..These data extend the canonical model of Rac1 inactivation and uncover Cav1-regulated polyubiquitylation as an additional mechanism to control Rac1 signalling...
  48. pmc HIV infection upregulates caveolin 1 expression to restrict virus production
    Shanshan Lin
    Department of Infectious Disease and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
    J Virol 84:9487-96. 2010
    b>Caveolin 1 (Cav-1) is a major protein of a specific membrane lipid raft known as caveolae...
  49. pmc Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein
    Elke Prade
    Department of Chemistry, Klinikum rechts der Isar, Technische Universitat Munchen, D 81675 Munich, Germany
    Mol Endocrinol 26:819-32. 2012
    ..These data indicate that bile acid-mediated down-regulation of Cav1 marks early changes in the squamous epithelium, which may contribute to onset of Barrett esophagus metaplasia and progression to BAC...
  50. pmc Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation
    Casey Trimmer
    Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Pathol 182:992-1004. 2013
    ..In summary, we demonstrate that loss of Cav1 affects several characteristics associated with aggressive human skin tumors and that this protein may be an important modulator of tumor growth and invasion in cSCC...
  51. doi Knock down of caveolin-1 affects morphological and functional hallmarks of human endothelial cells
    Luca Madaro
    Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy
    J Cell Biochem 114:1843-51. 2013
    ....
  52. ncbi Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation
    Xiangjian Zheng
    Program in Cell Signaling, Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Invest Dermatol 121:1487-95. 2003
    ..Phosphatidylglycerol, as a bioactive lipid, could potentially mediate the effects of the aquaporin 3-phospholipase D2 signaling module, with aquaporin 3 as a modulatory unit, in the regulation of keratinocyte function...
  53. pmc Direct control of caveolin-1 expression by FOXO transcription factors
    A Pieter J van den Heuvel
    Laboratory of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochem J 385:795-802. 2005
    ..Biol. Chem. 275, 20847-20852]. These findings suggest a novel mechanism by which FOXO factors can exert their cellular effects via transcriptional activation of caveolin-1...
  54. ncbi Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current
    Adam M Brainard
    Department of Physiology and Biophysics, Carver College of Medicine, University of Iowa, 5 660 Bowen Science Bldg, Iowa City, Iowa 52242, USA
    Am J Physiol Cell Physiol 289:C49-57. 2005
    ..These data indicate that the actin cytoskeleton is involved as part of a caveolar complex in the regulation of myometrial maxi-K channel function...
  55. ncbi Preliminary computational modeling of nitric oxide synthase 3 interactions with caveolin-1: influence of exon 7 Glu298Asp polymorphism
    Mandar S Joshi
    Center for Cardiovascular Medicine, The Research Institute at Nationwide Children s Hospital, Columbus Ohio 43205, USA
    Acta Biochim Biophys Sin (Shanghai) 40:47-54. 2008
    ..These alterations might also affect the protein function and explain the enhanced disease risk associated with the presence of Glu298Asp polymorphism in the NOS3 protein...
  56. ncbi Localization of RhoA GTPase to endothelial caveolae-enriched membrane domains
    D Gingras
    Laboratoire d Oncologie Moléculaire Ste Justine UQAM, Departement de Chimie Biochimie, Universite du Quebec a Montreal, Canada
    Biochem Biophys Res Commun 247:888-93. 1998
    ..These findings may provide new insights into the functions played by Rho proteins and caveolae in signal transduction events...
  57. doi Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells
    Fei Han
    Department of Pathology, Shanghai Medical College of Fudan University, and Huashan Hospital of Fudan University, Shanghai, China
    J Surg Res 159:443-50. 2010
    ....
  58. ncbi Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo
    P E Scherer
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 272:29337-46. 1997
    ..These results suggest that expression levels of caveolins 1, 2, and 3 can be independently up-regulated or down-regulated in response to a variety of distinct cellular cues...
  59. ncbi Caveolin-1 overexpression is associated with aggressive prostate cancer recurrence
    Jose A Karam
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
    Prostate 67:614-22. 2007
    ....
  60. doi Overexpression of caveolin-1 in hepatocellular carcinoma with metastasis and worse prognosis: correlation with vascular endothelial growth factor, microvessel density and unpaired artery
    Zhi Bo Zhang
    Institute of Hepatobiliary Surgery and Southwest Hospital, Third Military Medical University, Chongqing 400038, People s Republic of China
    Pathol Oncol Res 15:495-502. 2009
    ..Caveolin-1 expression correlates positively with VEGF, MVD and UA. These results suggest that caveolin-1 may play an important role in the progression of HCC and angiogenesis...
  61. pmc Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms
    W Suginta
    Department of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Biochem J 359:55-64. 2001
    ..Our results provide the basis for new hypotheses concerning novel ways in which CLIC proteins might be associated with cell membrane remodelling, the control of cell shape, and anion channel activity...
  62. ncbi Caveolin-1 expression is variably displayed in astroglial-derived tumors and absent in oligodendrogliomas: concrete premises for a new reliable diagnostic marker in gliomas
    Paola Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Am J Surg Pathol 31:760-9. 2007
    ..Finally, the lack of cav-1 immunoreactivity in oligodendrogliomas suggests its concrete application as a useful diagnostic marker...
  63. ncbi Caveolin-1 regulates EGFR signaling in MCF-7 breast cancer cells and enhances gefitinib-induced tumor cell inhibition
    Sophia Agelaki
    Laboratory of Tumor Cell Biology, School of Medicine, University of Crete, Heraklion, Voutes, Greece
    Cancer Biol Ther 8:1470-7. 2009
    ..This is associated with enhanced antitumor effects of gefitinib suggesting a role for EGFR inhibition in caveolin-1 overexpressing breast cancers...
  64. doi eNOS and caveolin-1 gene polymorphisms interaction and intima media thickness: a proof of concept study in ESRD patients
    Alessandra Testa
    CNR IBIM, National Research Council Institute of Biomedicine, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy
    Am J Hypertens 25:103-8. 2012
    ....
  65. ncbi Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells
    Oscar M Tirado
    Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057, USA
    Cancer Res 66:9937-47. 2006
    ..Overall, these data identify CAV1 as a key determinant of the tumorigenicity of ESFT and imply that targeting CAV1 may allow the development of new molecular therapeutic strategies for ESFT patients...
  66. ncbi Caveolin-1 and VEGF-C promote lymph node metastasis in the absence of intratumoral lymphangiogenesis in non-small cell lung cancer
    Minhua Li
    Department of Pathology School of Basic Medicine Science, Wuhan University, China
    Tumori 96:734-43. 2010
    ..This study aimed to define the caveolin-1 and VEGF-C expression and lymph vessel density in NSCLC and look for correlations with clinicopathological features in NSCLC...
  67. ncbi Acquisition of anoikis resistance up-regulates caveolin-1 expression in human non-small cell lung cancer cells
    Hasseri Halim
    Pharmaceutical Technology International Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    Anticancer Res 32:1649-58. 2012
    ..Anoikis is a key inhibitory step in the process of cancer cell metastasis. Knowledge regarding the adaptive response resulting in resistance to anoikis may benefit the development of new therapies...
  68. ncbi A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth
    K K Wary
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cell 94:625-34. 1998
    ..These findings reveal an unexpected function of caveolin-1 and Fyn in integrin signaling and anchorage-dependent cell growth...
  69. ncbi Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers
    J A Engelman
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    FEBS Lett 436:403-10. 1998
    ..As it has been previously shown that caveolin 1 possesses transformation suppressor activity (Koleske, A.J., Baltimore, D. and M.P. Lisanti (1995) Proc. Natl...
  70. ncbi Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases
    S Li
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479, USA
    J Biol Chem 271:29182-90. 1996
    ..Fourth, it is membrane-proximal, suggesting that it may be involved in other potential protein-protein interactions. Thus, we have termed this 20-amino acid stretch of caveolin residues the caveolin scaffolding domain...
  71. ncbi Regulation of G protein-coupled receptor kinases by caveolin
    C V Carman
    Departments of Biochemistry and Molecular Pharmacology and Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 274:8858-64. 1999
    ..These data reveal a novel mode for the regulation of GRKs that is likely to play an important role in their cellular function...
  72. ncbi Caveolin-1, a putative tumour suppressor gene
    B Razani
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biochem Soc Trans 29:494-9. 2001
    ..Here we describe the functional roles of the caveolin gene family and summarize the evidence that supports a role for caveolae as mediators of a number of cellular signalling processes, including apoptosis...
  73. ncbi Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage
    Kentaro Kato
    Department of Surgical Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Cancer 94:929-33. 2002
    ..Recently caveolin-1 was identified as a metastasis-related gene in prostate carcinoma. However, the clinical impact of caveolin-1 expression in esophageal carcinoma remains unknown...
  74. ncbi Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization
    Kuk Wha Lee
    Division of Pediatric Endocrinology, Mattel Children s Hospital, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 279:469-76. 2004
    ..Suppression of IGFBP-3 internalization by TfR1 blockade inhibited IGFBP-3-induced apoptosis. Together, these data indicate that the actions of IGFBP-3 are mediated by internalization via distinct endocytic pathways...
  75. pmc Links between CD147 function, glycosylation, and caveolin-1
    Wei Tang
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 15:4043-50. 2004
    ..These results help explain the previously established tumor suppressor functions of caveolin-1...
  76. pmc Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status
    Tianhong Li
    Department of Cancer Biology, Kimmel Cancer Center, Bluemle Life Sciences Building, Room 933, 233 S 10th Street, Philadelphia, PA 19107, USA
    Am J Pathol 168:1998-2013. 2006
    ..Finally, we discuss the possibility that sporadic Cav-1 mutations may act as an initiating event in human breast cancer pathogenesis...
  77. ncbi Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis
    Kay Savage
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 13:90-101. 2007
    The distribution and significance of caveolin 1 (CAV1) expression in different breast cell types and role in breast carcinogenesis remain poorly understood. Both tumor-suppressive and oncogenic roles have been proposed for this protein...
  78. ncbi Caveolin-1 and liver regeneration: role in proliferation and lipogenesis
    Philippe G Frank
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cell Cycle 6:115-6. 2007
    ..These findings are consistent with the importance of a lipogenesis program in the regulation of liver regeneration...
  79. ncbi The overexpression of caveolin-1 and caveolin-2 correlates with a poor prognosis and tumor progression in esophageal squamous cell carcinoma
    Takuya Ando
    Department of Surgery II, Nagoya City University Medical School, Japan
    Oncol Rep 18:601-9. 2007
    ..0105 and 0.0424 for CAV1 and CAV2, respectively). These results suggest that positive staining for CAV1 and CAV2 could be a potentially useful prognostic marker of ESCC...
  80. ncbi Caveolae/caveolin-1 are important modulators of store-operated calcium entry in Hs578/T breast cancer cells
    Hua Zhu
    The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick 08901, USA
    J Pharmacol Sci 106:287-94. 2008
    ..Our results suggest alteration of SOCE by caveolin-1 expression changes could be one of the mechanisms contributing to the progression of breast cancer...
  81. doi Caveolin-1 expression in human breast lobular cancer progression
    Giuseppe Perrone
    Department of Anatomical Pathology, Università Campus Bio Medico di Roma, Rome, Italy
    Mod Pathol 22:71-8. 2009
    ....
  82. pmc Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma
    H Zhang
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Br J Cancer 99:1684-94. 2008
    ....
  83. doi Caveolin-1 overexpression correlates with tumour progression markers in pancreatic ductal adenocarcinoma
    Cristiana Pistol Tanase
    Victor Babes National Institute of Pathology, 99 101 Splaiul Independentei, Bucharest, 050096 Romania
    J Mol Histol 40:23-9. 2009
    ..795, P < 0.001). Based on the results of this study, the inclusion of Cav-1 in a putative panel of biomarkers predicting pancreatic cancer aggressiveness is warranted...
  84. pmc Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa
    Milan Bajmoczi
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 297:C263-77. 2009
    ..Thus efficient initiation of innate immunity to P. aeruginosa requires formation of an epithelial "internalization platform" involving both caveolin-1 and functional, laterally mobile CFTR...
  85. ncbi Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
    J Couet
    The Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 272:30429-38. 1997
    ..In this regard, caveolae-coupled signaling might explain how linear signaling pathways can branch and interconnect extensively, forming a signaling module or network...
  86. ncbi Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14)
    H Lee
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:35150-8. 2001
    ..Taken together, our data identify a series of novel lipid-lipid-based interactions as important regulatory factors for coupling caveolin-1 to the c-Src tyrosine kinase in vivo...
  87. ncbi Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells
    Jürgen Zschocke
    Neurodegeneration Group, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Biol Chem 277:38772-80. 2002
    ..The observed mechanism of gene silencing by ER alpha may have implications for the transcriptional regulation of further ER alpha target genes...
  88. ncbi Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors
    Anushree Bhatnagar
    Department of Biochemistry, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA
    J Biol Chem 279:34614-23. 2004
    ..These studies provide compelling evidence for a prominent role of Cav-1 in regulating the functional activity of not only 5-HT(2A) serotonin receptors but also selected Galpha(q)-coupled receptors...
  89. ncbi Caveolin-1 and cancer multidrug resistance: coordinate regulation of pro-survival proteins?
    Maria Shatz
    Leuk Res 28:907-8. 2004
  90. ncbi Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line
    Alicia Llorente
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, Ma drid, 28049, Spain
    J Cell Sci 117:5343-51. 2004
    ..Our results suggest that MAL family proteins are associated with caveolin-1 in a multivesicular compartment that may be involved in prostasomal secretion in PC-3 cells...
  91. ncbi Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues
    Hyun Ah Kim
    Department of Surgery, College of Medicine, Ewha Womans University, Seoul, Korea
    Exp Mol Pathol 80:165-70. 2006
    ....
  92. ncbi Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin
    Vicente A Torres
    Laboratory of Cellular Communications, FONDAP Center for Molecular Studies of the Cell CEMC, Facultad de Medicina, Universidad de Chile, Av Independencia 1027, Santiago, Chile
    J Cell Sci 119:1812-23. 2006
    ..Taken together, these results suggest that anti-proliferative and pro-apoptotic properties of caveolin-1 may be attributed to reduced survivin expression via a mechanism involving diminished beta-catenin-Tcf/Lef-dependent transcription...
  93. ncbi Caveolin-1 controls BRCA1 gene expression and cellular localization in human breast cancer cells
    Chen Glait
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    FEBS Lett 580:5268-74. 2006
    ..In addition, immunostaining experiments demonstrate that Cav-1 induced the cytoplasmic sequestration of BRCA1...
  94. ncbi Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1
    Hemal H Patel
    Department of Anesthesiology, University of California, San Diego, CA, USA
    FASEB J 21:1565-74. 2007
    ..Accordingly, therapies targeted to post-translational modification of Src and Cav-1 may provide a novel approach for such protection...
  95. doi Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo
    Elena Tourkina
    Am J Physiol Lung Cell Mol Physiol 294:L843-61. 2008
    ..CSD peptide may be a prototype for novel treatments for human lung fibrosis that act, in part, by inhibiting the expression of ASMA and ECM proteins...
  96. doi Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion
    Bharat Joshi
    Department of Cellular and Physiological Sciences, Life Sciences Institute, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Cancer Res 68:8210-20. 2008
    ....
  97. doi Caveolin-1 regulates glioblastoma aggressiveness through the control of alpha(5)beta(1) integrin expression and modulates glioblastoma responsiveness to SJ749, an alpha(5)beta(1) integrin antagonist
    Sophie Martin
    Université Strasbourg 1 Institut Gilbert Laustriat, CNRS UMR 7175, Illkirch, France
    Biochim Biophys Acta 1793:354-67. 2009
    ..Mediator of caveolin-1 effects, alpha(5)beta(1) integrin, is also a marker for glioma aggressiveness and an efficient target for the treatment of glioma especially the ones exerting the highest aggressive phenotype...
  98. pmc SDPR induces membrane curvature and functions in the formation of caveolae
    Carsten G Hansen
    MRC LMB, Cambridge, UK
    Nat Cell Biol 11:807-14. 2009
    ..STB colocalizes extensively with both SDPR and caveolin 1. Loss of caveolae reduces the propensity of STB to induce membrane tubulation...
  99. doi Caveolin-1 expression in lung carcinoma varies according to tumour histotype and is acquired de novo in brain metastases
    Paola Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Histopathology 55:20-7. 2009
    ..To study caveolin-1 (Cav-1) expression in metastatic lung carcinomas...
  100. doi Caveolin-1 expression in diffuse gliomas: correlation with the proliferation index, epidermal growth factor receptor, p53, and 1p/19q status
    Valeria Barresi
    Department of Human Pathology, University of Messina, Messina, Italy
    Hum Pathol 40:1738-46. 2009
    ..In conclusion, the present study indicates that caveolin-1 is not useful as diagnostic marker to differentiate grade II astrocytomas from oligodendrogliomas...
  101. doi SR-BI, CD36, and caveolin-1 contribute positively to cholesterol efflux in hepatic cells
    To Quyen Truong
    Departement des Sciences Biologiques, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Cell Biochem Funct 28:480-9. 2010
    ..Overall, our results show that SR-BI is clearly involved in cholesterol efflux in mouse and human hepatic cells, while CD36 plays a significant role in human cells...

Research Grants75

  1. Exercise as a novel strategy to target methamphetamine-induced cerebrovascular to
    Michal Toborek; Fiscal Year: 2013
    ..We believe that the data obtained from this proposal will provide evidence that even moderate exercise can significantly contribute to brain regeneration in chronic cerebrovascular disorders. ..
  2. Structure and Function of Membrane Rafts
    Deborah Brown; Fiscal Year: 2009
    ..Nevertheless, caveolae are likely to play an important back-up role in regulating cellular signal transduction processes, which can lead to cancer when regulation breaks down. ..
  3. Implications of caveolae in Tat signaling and integrity of brain endothelium
    Min Seon Park; Fiscal Year: 2012
    ..This proposal is the first attempt to study the role of functional caveolae in the regulation of the blood-brain barrier in relationship to HIV-1 infection. ..
  4. David M Roth; Fiscal Year: 2016
    ..The work described in this proposal focuses on elucidating mechanisms to support the use of caveolin proteins as novel therapeutic targets for heart failure patients and is of relevance to the VA patient care mission. ..
  5. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2013
    ....
  6. Timothy J Kamp; Fiscal Year: 2016
    ..Our goal in this study is to identify novel signaling mechanisms and discover key proteins involved in protection against pathological cardiac hypertrophy so effective therapies for disease prevention can be designed. ..
  7. David M Roth; Fiscal Year: 2016
    ..Identification of root causes of cardiac dysfunction and importantly, studies which could lead to novel therapeutics of this common disease, are essential, and will be the focus of this proposal. ..
  8. Kerney Jebrell Glover; Fiscal Year: 2016
    ..A fundamental understanding of caveolin-1 structure and oligomerization will undoubtedly open the door to possible therapeutic interventions that could address diseases linked to caveolin misfunction. ..
  9. Endothelial BK Channel Regulation by Caveolae Targeting
    Hon Chi Lee; Fiscal Year: 2010
    ..Results of the proposed research will help us better understand not only the regulation of BK channels in endothelial cells, but also fundamental mechanisms that modulate endothelial function. ..
  10. William C Sessa; Fiscal Year: 2016
    ..Research supported by this grant may help identify new drugs that reduce heart disease and improve the quality of life of people suffering with cardiovascular disease. ..
  11. Zhenjia Wang; Fiscal Year: 2016
    ..We will test the usefulness of caveolae-mediated transcytosis of nanoparticles for efficient and effective delivery of anti-TNF-[unreadable] mAb in vivo. ..
  12. Caveolins in the Pathogenesis of Idiopathic Pulmonary Fibrosis
    Dan N Predescu; Fiscal Year: 2010
    ..It was shown that the levels of caveolin 1 (cav-1) are decreased in type I epithelial cells after radiation-induced lung injury, as well as in a model of ..
  13. Analysis of the Spatiotemporal Regulation of Lipolysis
    Lisa M DiPilato; Fiscal Year: 2012
    ..The information generated by this study will aid in the development of new therapeutics as well as our understanding of the mechanisms behind the spatiotemporal regulation of cellular signaling. ..
  14. Kathryn G Lamping; Fiscal Year: 2016
    ..We will compare the effects of inhibition (siRNA) or overexpression of caveolin-1 using viral transfection on vascular responses to specific serotonin receptor agonists or direct activation of rhoA in non-diabetic and diabetic mice. ..
  15. Regulation of Metabotropic glutamate Receptor Signaling by Caveolar Rafts
    Anna Francesconi; Fiscal Year: 2013
    ..abstract_text> ..
  16. David X Zhang; Fiscal Year: 2016
    ....
  17. Role of Caveolin in Scleroderma Tissue Fibrosis and Vasculopathy
    Sergio A Jimenez; Fiscal Year: 2012
    ..abstract_text> ..
  18. Sarah K England; Fiscal Year: 2016
    ..abstract_text> ..
  19. Endothelial BK Channels and Vasoreactivity Following Chronic Hypoxia
    Benjimen R Walker; Fiscal Year: 2013
    ..Although the current design investigates the role of CH to unmask this pathway, it is likely that these results could be extended in the future to other pathophysiological conditions where endothelial caveolae are similarly affected. ..
  20. Virend K Somers; Fiscal Year: 2014
    ....
  21. Timothy J Kamp; Fiscal Year: 2016
    ..These studies will provide mechanistic new insights into the control of cardiac repolarization and abnormalities in disease which can result in arrhythmias. ..
  22. MOLECULAR BASIS OF GLYCOSPHINGOLIPID BINDING SPECIFICITY
    Dinshaw J Patel; Fiscal Year: 2010
    ....
  23. Restoration of Fecal Continence in Aging IAS
    Khalil N Bitar; Fiscal Year: 2012
    ..Project Description Page 6 ..
  24. Carlos Fernandez Hernando; Fiscal Year: 2016
    ....
  25. Regulation of Cardiac Gene Expression by the L-type Calcium Channel, CaV1.2.
    ROBERT NATHAN CORRELL; Fiscal Year: 2011
    ..This work will help reveal the role of the cardiac L-type Ca2+ channel in regulation of gene expression related to disease and may suggest new translational strategies to combat heart failure. ..
  26. GERARD ANTHONY LUTTY; Fiscal Year: 2016
    ..This new knowledge of CC transport and how it changes in AMD will be invaluable in developing new systemic therapeutic nanoparticles for preventing retinal degeneration and CNV that occurs in AMD. ..
  27. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard D Minshall; Fiscal Year: 2011
    ....
  28. Integrin Mechanotransduction and caveolae-based signaling complexes
    VICTOR J RIZZO; Fiscal Year: 2012
    ....
  29. The role of caveolae &insulin signaling in CNS insulin transport
    GREGORY KEE PUM HONG; Fiscal Year: 2013
    ..As CNS insulin action is critical for controlling weight and energy balance, these transport mechanisms will likely represent attractive future pharmacologic targets in the treatment of obesity and DM2. ..
  30. Maternal Uterine Vascular Origins of Fetal Alcohol Spectrum Disorders
    Jayanth Ramadoss; Fiscal Year: 2013
    ..abstract_text> ..
  31. Debra L Laskin; Fiscal Year: 2016
    ....
  32. Extracellular Matrix Remodeling During Aging
    JANE M SOTTILE; Fiscal Year: 2010
    ....
  33. JESSICA OTIS; Fiscal Year: 2014
    ....
  34. Michael H Elliott; Fiscal Year: 2015
    ..The final aim will focus on the role that dysregulation of the Na/K-ATPase plays and how Cav-1 regulates ATPase activity. ..
  35. Caveolin 1: a novel modulator of the PP2A/ATM/p53 pathway
    Ferruccio Galbiati; Fiscal Year: 2013
    ....
  36. MY GEORGIA MAHONEY; Fiscal Year: 2014
    ..Determining the molecular mechanisms by which desmoglein 2 affects tumor growth and development has the potential of identifying new targets for therapeutic cancer treatments. ..
  37. Hemal H Patel; Fiscal Year: 2016
    ..Certain proteins found in the heart control the degree of injury. It is the goal of this study to discover key proteins involved in protection against a heart attack injury so that drugs can be appropriately designed. ..
  38. Hemal H Patel; Fiscal Year: 2016
    ..Aim 3: Determine the role of caveolin in nuclear envelope stability, modulation of gene expression, and the therapeutic potential of nuclear-targeted caveolin expression in the progression of diabetic cardiomyopathy. ..
  39. Caveolae Mediated Bacterial Uptake in the Urinary Tract
    Soman N Abraham; Fiscal Year: 2010
    ....
  40. Macrophages and Inflammatory Mediators in Silica-Induced Carcinogenesis
    DEBRA LYNN LASKIN; Fiscal Year: 2012
    ....
  41. Mike T Lin; Fiscal Year: 2014
    ..I will use an integrated repertoire of electrophysiology, vascular reactivity, biochemistry molecular biology, and electron microscopy. ..
  42. Tohru Fukai; Fiscal Year: 2016
    ..These studies will provide new insight into copper transporters as potential therapeutic targets for cardiovascular diseases such as atherosclerosis. ..
  43. Asrar B Malik; Fiscal Year: 2016
    ..Moreover the depth of understanding to be gained of the signaling pathways mediating the increase in lung vascular permeability will provide novel insights into the mechanisms of protein-rich pulmonary edema and ARDS. ..
  44. VASCULAR DISEASE IN HUMAN HEART TRANSPLANTATION
    Geraldine Miller; Fiscal Year: 2003
    ..These studies will enhance our understanding of the factors within allograft environments that, together with antigen recognition, lead to T cell activation and survival and the translation of these events to CAV. ..
  45. James E Loyd; Fiscal Year: 2016
    ..abstract_text> ..
  46. Physiological regulation of vascular function by mutant caveolin-1
    JOHN HENDRICK CHIDLOW; Fiscal Year: 2012
    ..The effects of the F92A Cav-1 mutation on physiologic responses of the vasculature ex vivo and 3. How the F92A Cav-1 mutation affects angiogenesis in vivo. ..
  47. Caveolin-1 and negative modulation of HIV-1 replication
    GLENN EDWARD SIMMONS; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Prevention methods have had little success to date. Identifying host factors that can suppress HIV expression, like caveolin-1, could provide insight to novel therapeutic or preventive strategies. ..
  48. Caveolin-1, Caveolae and Placental Angiogenesis
    DongBao Chen; Fiscal Year: 2007
    ....
  49. Peptide Therapy for Pulmonary Arterial Hypertension
    Jawaharlal M Patel; Fiscal Year: 2013
    ..Confirmation of the mechanism-based physiological approach for NO releasing PDE5 inhibitor function of this novel peptide in preclinical animal model is innovative for progression towards Phase I clinical trial for treatment of PH. ..
  50. Neuronal-Specific Splicing of CaV1.2 L-type Calcium Channels
    Kristin Webster; Fiscal Year: 2013
    ..I hypothesize that the e1b isoform will more efficiently induce CREB phosphorylation. These experiments will advance our understanding of how neuronal specific isoforms of CaV1.2 contribute to essential neuronal functions. ..
  51. GABA-B Receptor Modulation of Calcium Currents
    Michelle Mynlieff; Fiscal Year: 2010
    ..but these compounds also cause side effects such as drowsiness, mental slowing, and double vision. By increasing our understanding of the specific effects of GABA, it will be possible to design better drugs for these types of disorders. ..
  52. Chemokine receptor-4 regulation of Beta adrenergic-mediated calcium channel
    Sima T Tarzami; Fiscal Year: 2012
    ....
  53. FRANCOISE J HAESELEER; Fiscal Year: 2014
    ..These studies will fill a major void in our understanding of factors controlling photoreceptor Cav1 channels and how dysregulation of these channels may lead to CSNB2 and potentially other visual disorders. ..
  54. Secretagogue induced mechanisms regulating islet electrical activity
    DAVID AARON JACOBSON; Fiscal Year: 2012
    ..Understanding how secretagogues regulate islet electrical activity distinctly from KATP may help to develop new therapies that target specific elements of the excitation-secretion pathway. ..
  55. Papasani V Subbaiah; Fiscal Year: 2016
    ....
  56. Caveolin-2 and Endothelial Cell Function
    Grzegorz Sowa; Fiscal Year: 2012
    ..Thus, understanding the molecular mechanisms controlling angiogenesis is of key significance. The knowledge gained from this research will facilitate the treatment of cardiovascular and pulmonary disease, injuries, and cancer. ..
  57. Nitric Oxide and the Cellular Pathogenesis of Portal Hypertension
    Don C Rockey; Fiscal Year: 2012
    ..This leads to intestinal bleeding and severe clinical consequences. This proposal aims to understand the cause of elevated resistance to blood flow and would shed light on potential treatments for this problem. ..
  58. UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2016
    ..I hope to become a physician scientist who links the laboratory and clinical research aspects to improve the lives of patients with breast cancer. 1 ..
  59. Sheng He Huang; Fiscal Year: 2014
    ..2). Determine how Vim and PSF contribute to IbeA-induced pathogen penetration and PMN transmigration across the BBB by SCP analysis of cBMEC and genetic blockage of Vim. ..
  60. David S Wilkes; Fiscal Year: 2014
    ..abstract_text> ..
  61. SHAWN BRADY BENDER; Fiscal Year: 2016
    ..IR will be induced in wild-type and VSMC MR KO mice with a high-fat, high-sucrose diet and will be assessed by glucose tolerance testing. ..
  62. Fatty Acid Synthase, Caveolin-1 and Membrane Microdomains in Prostate Cancer
    Dolores Di Vizio; Fiscal Year: 2012
    ..abstract_text> ..
  63. Masayuki Yazawa; Fiscal Year: 2015
    ..abstract_text> ..
  64. OLIVIA RUTH BUONARATI; Fiscal Year: 2015
    ..2-associated disorders in the central nervous system, including stroke, depression, anxiety, senility and Alzheimer's disease. ..
  65. GANESAN LENIN KAMATCHI; Fiscal Year: 2015
    ..To be specific, this Aim will identify the Ser/Thr PKC phosphorylation sites of Cav [unreadable]1 subunits that are targeted by the Cav[unreadable] and PKC isozymes and study the mechanism of interaction between these three proteins. ..
  66. Raft/Caveolar Mechanisms in Pulmonary Hypertension
    PRAVIN SEHGAL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  67. Suresh C Tyagi; Fiscal Year: 2016
    ..The results of the proposed research should uncover the molecular mechanisms regulating Hcy-Fg-Ab-collagen complex formation and lead to effective strategies for the treatment of cerebrovascular complications during diseases such as AD. ..
  68. Johannes W Hell; Fiscal Year: 2016
    ..Because ? ARs also associate with Cav1.2 in heart, smooth muscle and pancreas, spatially restricted cAMP signaling is of wide interest beyond its role in the brain. ..
  69. AKAP Regulation of Neuronal L-type Calcium Channel Signaling to the Nucleus
    MARK L DELL'ACQUA; Fiscal Year: 2013
    ....
  70. Role of caveolae in signaling in fat cells
    Paul F Pilch; Fiscal Year: 2010
    ....
  71. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2009
    ..Mechanistic insights derived from these studies may suggest new therapeutic approaches in the treatment of acute liver injury induced by acetaminophen. ..
  72. Molecular Mechanisms Mediating Resistance to Leptin Signaling During Fat Gain
    Virend Somers; Fiscal Year: 2009
    ..In addition the results of our proposed studies may be critical in development of therapeutics relating to leptin resistance and obesity. ..