CATSPER1

Summary

Gene Symbol: CATSPER1
Description: cation channel sperm associated 1
Alias: CATSPER, SPGF7, cation channel sperm-associated protein 1, hCatSper, sperm ion channel, sperm-associated cation channel 1
Species: human

Top Publications

  1. ncbi A sperm ion channel required for sperm motility and male fertility
    D Ren
    Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 413:603-9. 2001
  2. doi The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
    Timo Strünker
    Center of Advanced European Studies and Research, Abteilung Molekulare Neurosensorik, Ludwig Erhard Allee 2, 53175 Bonn, Germany
    Nature 471:382-6. 2011
  3. doi Progesterone activates the principal Ca2+ channel of human sperm
    Polina V Lishko
    Department of Physiology, University of California San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F, 600 16th Street, San Francisco, California 94158, USA
    Nature 471:387-91. 2011
  4. pmc The CatSper channel: a polymodal chemosensor in human sperm
    Christoph Brenker
    Center of Advanced European Studies and Research caesar, Abteilung Molekulare Neurosensorik, Bonn, Germany
    EMBO J 31:1654-65. 2012
  5. pmc Positive selection on protein-length in the evolution of a primate sperm ion channel
    Ondrej Podlaha
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:12241-6. 2003
  6. doi Radiation hybrid mapping of seven porcine calcium channel genes (CATSPER1-4 and CNGA1-3) associated with male fertility
    Y Y Xing
    Institute of Veterinary Medicine, Georg August University of Gottingen, Burckhardtweg 2, 37077 Gottingen, Germany
    Anim Genet 39:573-4. 2008
  7. pmc Slo1 is the principal potassium channel of human spermatozoa
    Nadja Mannowetz
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States
    elife 2:e01009. 2013
  8. doi Genome-wide association study for poor sperm motility in Holstein-Friesian bulls
    D M Hering
    University of Warmia and Mazury in Olsztyn, Department of Animal Genetics, 10 719 Olsztyn, Poland
    Anim Reprod Sci 146:89-97. 2014
  9. pmc Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility
    Jean Ju Chung
    Howard Hughes Medical Institute, Department of Cardiology, Boston Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Cell 157:808-22. 2014
  10. pmc Direct action of endocrine disrupting chemicals on human sperm
    Christian Schiffer
    Center of Advanced European Studies and Research, Abteilung Molekulare Neurosensorik, Bonn, Germany
    EMBO Rep 15:758-65. 2014

Research Grants

  1. CarSpers:sperm-specific ion channels;targets for male contraceptives
    David E Clapham; Fiscal Year: 2013
  2. Yuriy Kirichok; Fiscal Year: 2015
  3. Gunda I Georg; Fiscal Year: 2016
  4. CatSper: Novel target for an oral contraceptive
    JAYHONG CHONG; Fiscal Year: 2003
  5. SPERM ION CHANNEL REGULATION
    HARVEY FLORMAN; Fiscal Year: 2002
  6. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
  7. The Protein Complex of a Sperm Ion Channel
    Dejian Ren; Fiscal Year: 2006
  8. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
  9. Annual SMRU Traveling Scholar Conference
    Susan Benoff; Fiscal Year: 2005
  10. Annual SMRU Traveling Scholars Conference
    Susan Benoff; Fiscal Year: 2006

Scientific Experts

  • Xinjiang Cai
  • S S Suarez
  • Sarah D Olson
  • E R S Roldan
  • Edgar Garza-López
  • Kenta Ishimoto
  • N H Ing
  • Shabnam Mohammadi
  • Susan H Benoff
  • A Darszon
  • Timo Strünker
  • Yuriy Kirichok
  • Chengyi Song
  • Lian Hu
  • Dejian Ren
  • Yuan yuan Yang
  • David E Clapham
  • Timothy A Quill
  • Anna Lobley
  • Di Zhang
  • Polina V Lishko
  • Betsy Navarro
  • Xu Hui Zeng
  • Jean Ju Chung
  • Jingsheng Xia
  • Gunda I Georg
  • Wardah Alasmari
  • Christopher L R Barratt
  • Jennifer Morris
  • Felipe A Navarrete
  • JAYHONG CHONG
  • Hong Gang Li
  • HARVEY FLORMAN
  • Anne E Carlson
  • Minerva Mata-Rocha
  • Stephen Publicover
  • Linda Lefievre
  • Sarah Costello
  • Honggang Li
  • Hua Feng Wang
  • Tao Luo
  • Min Liu
  • Astrid Müller
  • U Benjamin Kaupp
  • Stuart M Wilson
  • Steven Mansell
  • James F Smith
  • Xiao Ming Xia
  • Christopher J Lingle
  • Nadja Mannowetz
  • Christoph Brenker
  • Jackson Kirkman-Brown
  • Michael S Hildebrand
  • Matthew R Avenarius
  • Ondrej Podlaha
  • Alejandro Vicente-Carrillo
  • Jin Liu
  • Daisuke Yamazaki
  • I Urizar-Arenaza
  • Shameem Sultana Syeda
  • Maeve Shannon
  • Dario Krapf
  • Pablo E Visconti
  • Melissa R Miller
  • Ana M Salicioni
  • Antonio Alvau
  • Cheng Liang Xiong
  • Ai Hua Liao
  • Hannah L Williams
  • Anders Rehfeld
  • Akhand Pratap Singh
  • Celia M Santi
  • Reinhard Seifert
  • Niels E Skakkebaek
  • Luis Alvarez
  • D M Hering
  • Christian Schiffer
  • Sarah Martins da Silva
  • J Tantibhedhyangkul
  • Claudia L Trevino
  • Julio César Chávez
  • Javier Hernandez-Sanchez
  • Donner F Babcock
  • Singh Rajender
  • Ricardo Felix
  • Bertil Hille
  • Norma Oviedo
  • Normann Goodwin
  • Nachiket D Kashikar
  • Chengtao Yang

Detail Information

Publications104 found, 100 shown here

  1. ncbi A sperm ion channel required for sperm motility and male fertility
    D Ren
    Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 413:603-9. 2001
    ..Here we describe a putative sperm cation channel, CatSper, whose amino-acid sequence most closely resembles a single, six-transmembrane-spanning repeat of the voltage-..
  2. doi The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
    Timo Strünker
    Center of Advanced European Studies and Research, Abteilung Molekulare Neurosensorik, Ludwig Erhard Allee 2, 53175 Bonn, Germany
    Nature 471:382-6. 2011
    ..Here we show that progesterone activates the sperm-specific, pH-sensitive CatSper Ca(2+) channel...
  3. doi Progesterone activates the principal Ca2+ channel of human sperm
    Polina V Lishko
    Department of Physiology, University of California San Francisco, UCSF Mail Code 2140, Genentech Hall Room N272F, 600 16th Street, San Francisco, California 94158, USA
    Nature 471:387-91. 2011
    ..to mature human spermatozoa, we found that nanomolar concentrations of progesterone dramatically potentiate CatSper, a pH-dependent Ca(2+) channel of the sperm flagellum...
  4. pmc The CatSper channel: a polymodal chemosensor in human sperm
    Christoph Brenker
    Center of Advanced European Studies and Research caesar, Abteilung Molekulare Neurosensorik, Bonn, Germany
    EMBO J 31:1654-65. 2012
    The sperm-specific CatSper channel controls the intracellular Ca(2+) concentration ([Ca(2+)](i)) and, thereby, the swimming behaviour of sperm...
  5. pmc Positive selection on protein-length in the evolution of a primate sperm ion channel
    Ondrej Podlaha
    Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:12241-6. 2003
    ..b>CATSPER1 is a voltage-gated calcium channel found exclusively in the plasma membrane of the mammalian sperm tail and it is ..
  6. doi Radiation hybrid mapping of seven porcine calcium channel genes (CATSPER1-4 and CNGA1-3) associated with male fertility
    Y Y Xing
    Institute of Veterinary Medicine, Georg August University of Gottingen, Burckhardtweg 2, 37077 Gottingen, Germany
    Anim Genet 39:573-4. 2008
  7. pmc Slo1 is the principal potassium channel of human spermatozoa
    Nadja Mannowetz
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States
    elife 2:e01009. 2013
    ..Inhibition of hKSper by progesterone may depolarize the spermatozoon to open the calcium channel CatSper, thus raising [Ca(2+)] to produce hyperactivation and allowing sperm to fertilize an oocyte. DOI:http://dx.doi...
  8. doi Genome-wide association study for poor sperm motility in Holstein-Friesian bulls
    D M Hering
    University of Warmia and Mazury in Olsztyn, Department of Animal Genetics, 10 719 Olsztyn, Poland
    Anim Reprod Sci 146:89-97. 2014
    ..1 receptor (IGF1R), steroid-5-alpha-reductase, alpha polypeptide 2 (SRD5A2), cation channel, sperm associated 1 (CATSPER1) calpain 1 (mu/I) large subunit (CAPN1) were suggested to be significantly associated with sperm motility or ..
  9. pmc Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility
    Jean Ju Chung
    Howard Hughes Medical Institute, Department of Cardiology, Boston Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Cell 157:808-22. 2014
    ..Here, using genetics, super-resolution fluorescence microscopy, and phosphoproteomics, we investigate the CatSper-dependent mechanisms underlying this flagellar switch...
  10. pmc Direct action of endocrine disrupting chemicals on human sperm
    Christian Schiffer
    Center of Advanced European Studies and Research, Abteilung Molekulare Neurosensorik, Bonn, Germany
    EMBO Rep 15:758-65. 2014
    ..We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis...
  11. pmc Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex
    Xinjiang Cai
    Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
    Mol Biol Evol 31:2735-40. 2014
    ..Particularly, our findings reveal the conservation of the CatSper channel complex in Au. limacinum and C...
  12. doi The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression
    Minerva Mata-Rocha
    Unidad de Investigación Médica en Enfermedades Metabólicas, Instituto Mexicano del Seguro Social IMSS, Mexico DF 06720, Mexico Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional CINVESTAV, Mexico DF 07360, Mexico
    FEBS Lett 588:3352-60. 2014
    ..In spite of its central role in male fertility, the transcriptional mechanisms that regulate Catsper1 expression are ill defined...
  13. pmc Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential
    J Tantibhedhyangkul
    Department of Obstetrics and Gynecology, Duke University, Durham, NC, USA
    Andrology 2:875-83. 2014
    ..was inhibited by a specific PR antagonist, but not affected by an inhibitor to the progesterone-dependent Catsper voltage-activated channel...
  14. pmc SLO3 K+ channels control calcium entry through CATSPER channels in sperm
    Julio César Chávez
    From the Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110 and the Instituto de Biotecnología, Universidad Nacional Autonoma de Mexico UNAM, 62210 Cuernavaca, Mexico
    J Biol Chem 289:32266-75. 2014
    ..sperm-specific potassium channel (SLO3) controls Ca(2+) entry into sperm through a sperm-specific Ca(2+) channel, CATSPER, in a totally unanticipated manner...
  15. doi CatSper channel, sperm function and male fertility
    Akhand Pratap Singh
    The Central Drug Research Institute, Lucknow, India
    Reprod Biomed Online 30:28-38. 2015
    ..In fact, mutations in CatSper1 and 2 have been identified in infertile individuals; however, CatSper3 and 4 have not been explored...
  16. pmc The CatSper channel controls chemosensation in sea urchin sperm
    Reinhard Seifert
    Center of Advanced European Studies and Research caesar, Abteilung Molekulare Neurosensorik, Bonn, Germany Marine Biological Laboratory, Woods Hole, MA, USA
    EMBO J 34:379-92. 2015
    ..The underlying Ca(2+) channel and its mechanisms of activation are unknown. Here, we identify CatSper Ca(2+) channels in the flagellum of A. punctulata sperm...
  17. pmc Biphasic role of calcium in mouse sperm capacitation signaling pathways
    Felipe A Navarrete
    Department of Veterinary and Animal Science, Integrated Sciences Building, University of Massachusetts, Amherst, Massachusetts
    J Cell Physiol 230:1758-69. 2015
    ..Interestingly, contrary to wild-type mouse sperm, sperm from CatSper1 KO mice underwent PKA activation and an increase in tyrosine phosphorylation upon incubation in nominal zero Ca(2+..
  18. pmc SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility
    Xu Hui Zeng
    Institute of Life Science, Nanchang University, Nanchang, Jiangxi, China and
    Proc Natl Acad Sci U S A 112:2599-604. 2015
    ..In mice, the Ca(2+) conductance (alkalization-activated Ca(2+)-permeable sperm channel, CATSPER) arises from an ensemble of CATSPER subunits, whereas the K(+) conductance (sperm pH-regulated K(+) current, ..
  19. pmc Cell-penetrating peptides, targeting the regulation of store-operated channels, slow decay of the progesterone-induced [Ca2+]i signal in human sperm
    Jennifer Morris
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Mol Hum Reprod 21:563-70. 2015
    ..of human sperm, including a contribution to the transient [Ca(2+)]i elevation that occurs upon activation of CatSper, a sperm-specific cation channel localized to the flagellum, by progesterone...
  20. pmc Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa
    Hannah L Williams
    Reproductive and Developmental Biology, Medical School, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK Assisted Conception Unit, NHS Tayside, Ninewells Hospital, Dundee DD1 9SY, UK
    Hum Reprod 30:2737-46. 2015
    Are significant abnormalities of CatSper function present in IVF patients with normal sperm concentration and motility and if so what is their functional significance for fertilization success?
  21. doi The opioid peptide beta-endorphin stimulates acrosome reaction in human spermatozoa
    I Urizar-Arenaza
    Department of Physiology, Faculty of Medicine and Dentistry, University of the Basque Country UPV EHU, Leioa, Bizkaia, Spain
    Andrology 4:143-51. 2016
    ..by cumulus oophorus cells and known to regulate acrosome reaction by activating the specific calcium channel CatSper, endogenous opioid peptides such as beta-endorphin and met-enkephalin are present at high concentrations in the ..
  22. pmc The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex
    Shameem Sultana Syeda
    Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55414, United States
    ACS Chem Biol 11:452-9. 2016
    ..evokes a large calcium influx in the motile gametes, which could proceed through the cation channel of sperm (CatSper) complex...
  23. doi Matrine compromises mouse sperm functions by a [Ca(2+)]i-related mechanism
    Tao Luo
    Institute of Life Science, Nanchang University, Nanchang, Jiangxi 330031, PR China Electronic address
    Reprod Toxicol 60:69-75. 2016
    ..The current and gene expression of the sperm specific Ca(2+) channel, CatSper, which modulates Ca(2+) influx in sperm, were decreased in testes of matrine-exposed mice...
  24. doi In vitro bioassay investigations of the endocrine disrupting potential of steviol glycosides and their metabolite steviol, components of the natural sweetener Stevia
    Maeve Shannon
    Institute for Global Food Security, School of Biological Sciences, Queen s University Belfast, Northern Ireland, United Kingdom
    Mol Cell Endocrinol 427:65-72. 2016
    ..001). Additionally, steviol was found to induce an agonistic response on CatSper, a progesterone receptor of sperm, causing a rapid influx of Ca(2+)...
  25. doi The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction
    Daisuke Yamazaki
    Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Cell Sci 129:1940-9. 2016
    ..of Cnnm4-deficient sperm are very similar to those of sperm lacking a functional cation channel of sperm (CatSper) channel, which plays an essential role in Ca(2+) influx during sperm capacitation...
  26. doi Bisphenol A Impairs Mature Sperm Functions by a CatSper-Relevant Mechanism
    Hua Feng Wang
    Institute of Life Science, Nanchang University, Nanchang, Jiangxi, 330031, PR China
    Toxicol Sci 152:145-54. 2016
    ..acrosome reaction (AR) ratio together with the expression/current levels of the sperm-specific Ca(2+ )channel (CatSper) and K(+ )channel (KSper) were examined...
  27. pmc Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models
    Felipe A Navarrete
    Department of Veterinary and Animal Science, Integrated Sciences Building, University of Massachusetts, Amherst MA, USA
    Sci Rep 6:33589. 2016
    ..We now show that a pulse of Ca(2+) ionophore induces fertilizing capacity in sperm from infertile CatSper1 (Ca(2+) channel), Adcy10 (soluble adenylyl cyclase) and Slo3 (K(+) channel) KO mice...
  28. doi The CatSper channel modulates boar sperm motility during capacitation
    Alejandro Vicente-Carrillo
    Department of Clinical and Experimental Medicine, Linkoping University, Linkoping, Sweden
    Reprod Biol . 2017
    The cation channel of sperm (CatSper) comprises four transmembrane subunits specifically expressed in human, equine, murine and ovine spermatozoa, apparently implicated in capacitation, hyperactivation and acrosome exocytosis...
  29. pmc The control of male fertility by spermatozoan ion channels
    Polina V Lishko
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 74:453-75. 2012
    ..b>CatSper, a pH-regulated, calcium-selective ion channel, and KSper (Slo3) are core regulators of sperm tail calcium entry ..
  30. doi Immunization of male mice with B-cell epitopes in transmembrane domains of CatSper1 inhibits fertility
    Honggang Li
    Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Fertil Steril 97:445-52. 2012
    To evaluate the contraceptive ability of two B-cell epitopes in CatSper1.
  31. ncbi Ion channels in sperm physiology and male fertility and infertility
    Kamla Kant Shukla
    Division of Endocrinology, Central Drug Research Institute, Lucknow, UP, India
    J Androl 33:777-88. 2012
    ..The presence of the sperm-associated cation channel (CatSper1-4) gene family, proton voltage-gated ion channel (Hv1), potassium voltage-gated ion channel (SLO3/KCNU1), ..
  32. doi A caged progesterone analog alters intracellular Ca2+ and flagellar bending in human sperm
    M Rocio Servin-Vences
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico UNAM, Apdo Postal 510 3, Cuernavaca, Morelos 62250, Mexico
    Reproduction 144:101-9. 2012
    ..Our finding is mostly consistent with the recent discovery that progesterone activates CatSper channels in human spermatozoa, but not in mouse spermatozoa.
  33. doi Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa
    V Sagare-Patil
    Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, India
    Int J Androl 35:633-44. 2012
    ..concentration of progesterone is not absolutely dependent on activation of T-type voltage-gated Ca(2+) channel or CatSper as Mibefradil did not completely abrogate progesterone-mediated effects...
  34. pmc 2-APB-potentiated channels amplify CatSper-induced Ca(2+) signals in human sperm
    Linda Lefievre
    Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Biochem J 448:189-200. 2012
    ..In accordance with recent reports that progesterone directly activates CatSper, the [Ca2+]i transient was detectable in the anterior flagellum (where CatSper is expressed) 1-2 s before ..
  35. doi A Chinese herbal decoction can increase the intracellular Ca2+ concentration and CatSper1 expression in mouse sperm tails
    Shaobo Luo
    Department of Andrology, Air Force General Hospital of PLA, Beijing 100142, PR China
    Mol Med Rep 7:195-200. 2013
    ..on the intracellular calcium (Ca2+) concentration of sperm and the expression of the cation channel 1 of sperm (CatSper1), which is a calcium-channel protein specific to sperm tail, in a murine model of asthenospermia induced with ..
  36. doi Molecular cloning and analysis of the Catsper1 gene promoter
    Minerva Mata-Rocha
    Unidad de Investigación Médica en Enfermedades Metabólicas, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social IMSS, México DF CP 06720, Mexico
    Mol Hum Reprod 19:336-47. 2013
    ..Here, we report the cloning and characterization of the promoter regions in the human and murine Catsper1 genes...
  37. pmc Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm
    Wardah Alasmari
    From the Reproductive and Developmental Biology, Medical School, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 288:6248-58. 2013
    ..Activation of CatSper (by raising pHi or stimulating with progesterone) caused sustained [Ca(2+)]i elevation but did not induce ..
  38. pmc The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation
    Wardah Alasmari
    Reproductive and Developmental Biology, Medical School, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, UK
    Hum Reprod 28:866-76. 2013
    ..e. related to fertilization success at IVF?..
  39. pmc Investigation in vitro Expression of CatSper Sub Fragment followed by Production of Polyclonal Antibody: Potential Candidate for The Next Generation of Non Hormonal Contraceptive
    Mahboobeh Nazari
    1 Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran 2 Department of Recombinant Technology Research, Nanobiotechnology Research Center, Avicenna Research Institute, Academic Center for Education, Culture and Research ACECR, Tehran, Iran
    Cell J 14:215-24. 2012
    b>CatSper is a voltage-sensitive calcium channel that is specifically expressed in the testis and it has a significant role in sperm performance. CatSper (1-4) ion channel subunit genes, causes sperm cell hyperactivation and male fertility...
  40. pmc Levels of Tektin 2 and CatSper 2 in normozoospermic and oligoasthenozoospermic men and its association with motility, fertilization rate, embryo quality and pregnancy rate
    Rashmi Bhilawadikar
    Jaslok Hospital, 15, Dr G Deshmukh Marg, Mumbai 26, India
    J Assist Reprod Genet 30:513-23. 2013
    To compare the expression profiles of Tektin 2 and CatSper 2 motility proteins in the spermatozoa of normozoospermic and oligoasthenozoospermic men and determine its correlation with sperm motility, fertilization rate, embryo quality and ..
  41. pmc Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient
    James F Smith
    Department of Urology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 110:6823-8. 2013
    ..progesterone-dependent Ca(2+) influx into human spermatozoa is primarily mediated by cationic channel of sperm (CatSper), the principal flagellar Ca(2+) channel of sperm, conclusive loss-of-function genetic evidence for activation of ..
  42. doi Progesterone utilizes the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction
    Vrushali Sagare-Patil
    Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health, Indian Council of Medical Research, JM Street, Parel, Mumbai 400 012, India
    Mol Cell Endocrinol 374:82-91. 2013
    ..The activation of AKT in response to progesterone is calcium dependent and the CatSper channel inhibitor mibefradil significantly reduced progesterone mediated AKT phosphorylation...
  43. doi The anti-inflammatory drug celecoxib inhibits T-type Ca2+ currents in spermatogenic cells yet it elicits the acrosome reaction in mature sperm
    E Balderas
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico UNAM, Avenida Universidad 2001, Col Chamilpa, C P 62210 Cuernavaca Mor, Mexico
    FEBS Lett 587:2412-9. 2013
    ..ability Cx has to alkalinize intracellular pH (pHi), which is known to activate the sperm specific Ca(2+) channel CatSper. As the Cx induced [Ca(2+)]i increase is sensitive to mibefradil, a CatSper blocker, this channel may mediate the ..
  44. pmc Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa
    Xu Hui Zeng
    Institute of Life Science, Nanchang University, Nanchang, Jiangxi 330031, China
    J Gen Physiol 142:305-13. 2013
    ..After deletion of any of four CATSPER subunit genes (CATSPER1-4), the major remaining current in mouse sperm is alkalization-activated KSPER current...
  45. doi CatSper and the relationship of hyperactivated motility to intracellular calcium and pH kinetics in equine sperm
    Shavahn C Loux
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas
    Biol Reprod 89:123. 2013
    ..b>CATSPER1 mRNA was identified in equine sperm by PCR, and CATSPER1 protein was localized to the principal piece on ..
  46. pmc p,p'-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations
    Renata S Tavares
    Biology of Reproduction and Stem Cell Group, CNC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3001 401, Portugal
    Hum Reprod 28:3167-77. 2013
    ..Is the environmental endocrine disruptor p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) able to induce non-genomic changes in human sperm and consequently affect functional sperm parameters?..
  47. ncbi Ion channels. Swimming with sperm
    D L Garbers
    Nature 413:579, 581-2. 2001
  48. pmc A voltage-gated ion channel expressed specifically in spermatozoa
    T A Quill
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Department of Pharmacology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 98:12527-31. 2001
    ..Recently, another voltage-gated channel (CatSper) that has features similar to the one reported here was discovered...
  49. pmc Identification of human and mouse CatSper3 and CatSper4 genes: characterisation of a common interaction domain and evidence for expression in testis
    Anna Lobley
    Target Discovery, Inpharmatica Ltd, 60 Charlotte Street, London W1T 2NU, UK
    Reprod Biol Endocrinol 1:53. 2003
    b>CatSper1 and CatSper2 are two recently identified channel-like proteins, which show sperm specific expression patterns...
  50. pmc CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm
    Anne E Carlson
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:14864-8. 2003
    ..Here, we show that mouse CatSper1 is essential for depolarization-evoked Ca2+ entry and for hyperactivated movement, a key flagellar function...
  51. ncbi CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility
    Parvaneh Nikpoor
    Department of Genetics, Faculty of Basic Sciences, Tarbiat Modarres University, Tehran, 14115 175, Iran
    Hum Reprod 19:124-8. 2004
    ..for Ca2+ channels residing in sperm has led to the recent cloning and characterization of a novel gene, named CatSper, which codes for a unique Ca2+ channel expressed exclusively in the testis...
  52. ncbi Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4
    Gbolahan W Okunade
    Department of Molecular Genetics, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    J Biol Chem 279:33742-50. 2004
    ..it is localized to the principle piece of the sperm tail, which is also the location of the major Ca2+ channel (CatSper) required for sperm motility...
  53. pmc Positive selection for indel substitutions in the rodent sperm protein catsper1
    Ondrej Podlaha
    Department of Ecology and Evolutionary Biology, University of Michigan, USA
    Mol Biol Evol 22:1845-52. 2005
    b>Catsper1 is a voltage-gated calcium channel located in the plasma membrane of the sperm tail and is necessary for sperm motility and fertility in mice...
  54. ncbi Identical phenotypes of CatSper1 and CatSper2 null sperm
    Anne E Carlson
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Biol Chem 280:32238-44. 2005
    Among several candidate Ca(2+) entry channels in sperm, only CatSper1 and CatSper2 are known to have required roles in male fertility...
  55. ncbi Catsper3 and catsper4 encode two cation channel-like proteins exclusively expressed in the testis
    Jing Ling Jin
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Biol Reprod 73:1235-42. 2005
    b>CATSPER1 and CATSPER2 are two cation channel-like proteins exclusively expressed in the testis and essential for normal sperm motility and male fertility...
  56. ncbi International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels
    David E Clapham
    Howard Hughes Medical Institute, Children s Hospital, Boston, MA 02115, USA
    Pharmacol Rev 57:451-4. 2005
  57. ncbi Insights into sperm cell motility signaling through sNHE and the CatSpers
    Timothy A Quill
    Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell Endocrinol 250:84-92. 2006
    ..of sNHE and the atypical adenylyl cyclase (sAC), while a failure of calcium entry requiring an apparent CatSper1 and -2 heteromeric ion channel correlates with a hyperactivation defect in these null animals...
  58. ncbi Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel
    Yuriy Kirichok
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital and Harvard Medical School Enders 1309, Boston, Massachusetts 02115, USA
    Nature 439:737-40. 2006
    ..This current is not present in spermatozoa lacking the sperm-specific putative ion channel protein, CatSper1. This plasma membrane protein of the six transmembrane-spanning ion channel superfamily is specifically localized ..
  59. ncbi The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa
    Hong Gang Li
    Centre of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Asian J Androl 8:301-6. 2006
    To investigate the distribution of cation channel of sperm 1 (CATSPER1) protein and the presence of CATSPER1 mRNA in human testis and ejaculated spermatozoa...
  60. ncbi Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity
    Di Zhang
    Neuroscience Research and Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Biol Chem 281:22332-41. 2006
    Sperm-specific CatSper1 and CatSper2 proteins are critical to sperm-hyperactivated motility and male fertility...
  61. ncbi [Expression characteristics of mouse Catsper--the structural protein of sperm hyperactivation]
    Yuan yuan Yang
    Animal Science and Technology College, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Zhonghua Nan Ke Xue 12:675-80. 2006
    To study the expression specificity in tissues of the Catsper and its expression rules, which is a specification channels in sperm and plays an important role in sperm hyperactivation.
  62. ncbi Voltage-dependent calcium channels in mammalian spermatozoa revisited
    Susan Benoff
    Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Front Biosci 12:1420-49. 2007
    ..However, the large number of sperm ion channel variants shared with other cell types make ion channels less attractive targets for male contraceptive ..
  63. pmc Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: Release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm
    Becky Marquez
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 303:214-21. 2007
    ..In sperm from CatSper1 or CatSper2 null mice, which lack functional flagellar alkaline-activated calcium currents, 50 microM thimerosal ..
  64. pmc All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility
    Huayu Qi
    Department of Cardiology, Howard Hughes Medical Institute, and Department of Neurobiology, Harvard Medical School, Enders 1309, Children s Hospital Boston, 320 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:1219-23. 2007
    ..Hyperactivation requires CatSper1 and CatSper2 putative ion channel genes, but the function of two other related genes (CatSper3 and CatSper4) is ..
  65. ncbi Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse
    Jingling Jin
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Biol Reprod 77:37-44. 2007
    Catsper3 and Catsper4 are two recently identified testis-specific genes homologous to Catsper1 and Catsper2 that have been shown to play an essential role in sperm hyperactivated motility and male fertility in mice...
  66. ncbi [CatSper and sperm hyperactivation]
    Li juan Kong
    Animal Science and Technology College, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China
    Zhonghua Nan Ke Xue 13:164-7. 2007
    ..b>CatSper family proteins are putative cation channels expressed exclusively in the membranes of the sperm flagellum...
  67. ncbi Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility
    Hong Gang Li
    Centre of Reproductive Medicine and Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Mol Hum Reprod 13:299-306. 2007
    ..The temporal expression profiles of CatSper1-4 mRNAs in the mouse testis during post-natal development through adulthood were investigated using real-time RT-..
  68. pmc KSper, a pH-sensitive K+ current that controls sperm membrane potential
    Betsy Navarro
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:7688-92. 2007
    ..reproductive tract, the spermatozoan cytoplasm alkalinizes, which in turn activates a Ca2+-selective current (I(CatSper)) required for hyperactivated motility...
  69. ncbi CatSperbeta, a novel transmembrane protein in the CatSper channel complex
    Jin Liu
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:18945-52. 2007
    ..Using a transgenic approach, a CatSper1 complex was purified from mouse testis that contained heat shock protein 70-2, a testis-specific chaperone, and ..
  70. ncbi CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 77:551-9. 2007
    ..In addition, CatSper1-mutant sperm have lower intracellular ATP levels than wild-type sperm...
  71. ncbi Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum
    Susan S Suarez
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Soc Reprod Fertil Suppl 65:331-4. 2007
    ..is required for activation of motility, is restricted to the midpiece, while the plasma membrane calcium channels CatSper1 and CatSper2, which are required for hyperactivation of motility, are restricted to the principal piece...
  72. ncbi [Optimization of real time RT-PCR system for the quantitative estimation of CatSper1 mRNA levels in human and mouse mature spermatozoa]
    Hong Gang Li
    Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wu Han, Hubei 430030, China
    Zhonghua Nan Ke Xue 13:969-74. 2007
    To establish and optimize a real time RT-PCR system for determining the transcript levels of CatSper1 in human and mouse mature spermatozoa containing microamount of RNA.
  73. doi CatSper genes expression, semen characteristics and histology of testes in the contusive spinal cord-injured mice model
    J Rezaian
    Department of Anatomical Sciences, Tarbiat Modares University, Tehran, Iran
    Spinal Cord 47:76-81. 2009
    ..Experimental study...
  74. pmc Ion channels that control fertility in mammalian spermatozoa
    Betsy Navarro
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Department of Neurobiology, Harvard Medical School, Enders 1309, Children s Hospital Boston, 320 Longwood Avenue, Boston, MA 02115, USA
    Int J Dev Biol 52:607-13. 2008
    ..This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible...
  75. doi Control of hyperactivation in sperm
    Susan S Suarez
    Department of Biomedical Sciences, T5 002B Veterinary Research Tower, Cornell University Ithaca, NY 14853, USA
    Hum Reprod Update 14:647-57. 2008
    ..Hyperactivation is characterized by high amplitude, asymmetrical flagellar bending...
  76. pmc Probing neurochemical structure and function of retinal ON bipolar cells with a transgenic mouse
    Anuradha Dhingra
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6058, USA
    J Comp Neurol 510:484-96. 2008
    ..RGS10, RGS19 (GAIP), calbindin, GC1alpha2, GC1beta2, PDE5, PDE2A, amiloride-sensitive sodium channel ACCN4, and CatSper1. We then localized Kir2...
  77. pmc Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta
    Xinjiang Cai
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS ONE 3:e3569. 2008
    The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated Ca2+ channels that are crucial for sperm hyperactivation and male fertility...
  78. doi Inhibition of human sperm function and mouse fertilization in vitro by an antibody against cation channel of sperm 1: the contraceptive potential of its transmembrane domains and pore region
    Honggang Li
    Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Fertil Steril 92:1141-6. 2009
    To explore the contraceptive potential of the CatSper1 transmembrane domains and pore region in vitro.
  79. ncbi [Roles of calcium ion channels and its clinical significance in sperm motility]
    Yong Wang
    Department of Physiology, Medical College of Shantou University, Shantou, Guangdong 515041, China
    Zhonghua Nan Ke Xue 14:832-6. 2008
    ..voltage-gated Ca2+ channels (Cav channels), cyclic nucleotide-gated channels (CNGC), cation channels of sperm (CatSper) and the transient receptor potential (TRP) family...
  80. ncbi CatSper-null mutant spermatozoa are unable to ascend beyond the oviductal reservoir
    Katharine Ho
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Reprod Fertil Dev 21:345-50. 2009
    ..To test this hypothesis, the behaviour of CatSper-null mouse spermatozoa in the oviduct was compared with that of spermatozoa from heterozygotes...
  81. pmc Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 80:1092-8. 2009
    ..Instead, CATSPER channels localized in the distal portion of sperm (the principal piece) are required for the ZP-induced [Ca(2+)](..
  82. pmc Human male infertility caused by mutations in the CATSPER1 channel protein
    Matthew R Avenarius
    Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109 0618, USA
    Am J Hum Genet 84:505-10. 2009
    ..1, flanked by markers D11S1765 and D11S4139. This region contains the human CATSPER1 gene...
  83. pmc A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein
    Haikun Wang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 81:539-44. 2009
    All four CATSPER channel pore-forming subunits (CATSPER1-4) are localized in the sperm principal piece...
  84. pmc Ca2+-stores in sperm: their identities and functions
    Sarah Costello
    School of Biosciences, University of Birmingham, Birmingham B152TT, UK
    Reproduction 138:425-37. 2009
    ..of the sperm discretely to control mobilisation of these stores and the functional interaction of stored Ca2+ at the sperm neck/midpiece with CatSper channels in the principal piece in regulation of the activities of mammalian sperm.
  85. pmc Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation
    Anne E Carlson
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e6844. 2009
    The four sperm-specific CatSper ion channel proteins are required for hyperactivated motility and male fertility, and for Ca(2+) entry evoked by alkaline depolarization...
  86. pmc The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent
    Jingsheng Xia
    Department of Biology, University of Pennsylvania, 415 S University Ave, Philadelphia, Pennsylvania 19104, USA
    Reprod Biol Endocrinol 7:119. 2009
    ..Both of these processes require extracellular calcium, but how calcium enters sperm during capacitation is not well understood...
  87. pmc Up-regulation of CatSper genes family by selenium
    Shabnam Mohammadi
    Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Reprod Biol Endocrinol 7:126. 2009
    b>CatSper1-4 are a unique family of sperm cation channels, which are exclusively expressed in the testis and play an important role in sperm motility and male fertility...
  88. doi Effects of sodium fluoride on hyperactivation and Ca2+ signaling pathway in sperm from mice: an in vivo study
    Zilong Sun
    Shanxi Key Laboratory of Ecological Animal Science and Environmental Medicine, Shanxi Agricultural University, Taigu, 030801 Shanxi, People s Republic of China
    Arch Toxicol 84:353-61. 2010
    ..was to investigate the effect of sodium fluoride (NaF) on sperm hyperactivation, Ca2+/CALM-CAMK2 signaling, and CatSper1 and CatSper2 mRNA expression in mice sperm...
  89. doi A model of CatSper channel mediated calcium dynamics in mammalian spermatozoa
    Sarah D Olson
    Mathematics Department, Tulane University, 6823 St Charles Ave, New Orleans, LA 70118, USA
    Bull Math Biol 72:1925-46. 2010
    ..It has been observed that Ca(2+) entry through CatSper channels triggers a tail to head Ca(2+) propagation in mouse sperm, as well as a sustained increase of Ca(2+) in ..
  90. doi Calcium signaling through CatSper channels in mammalian fertilization
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Physiology (Bethesda) 25:165-75. 2010
    ..This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility...
  91. pmc Genetic male infertility and mutation of CATSPER ion channels
    Michael S Hildebrand
    Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
    Eur J Hum Genet 18:1178-84. 2010
    ..Recently, we identified insertion mutations of the CATSPER1 gene in families with recessively inherited nonsyndromic male infertility (NSMI)...
  92. pmc The role of Hv1 and CatSper channels in sperm activation
    Polina V Lishko
    Department of Physiology, University of California San Francisco, San Francisco, CA 94158, USA
    J Physiol 588:4667-72. 2010
    ..main H(+) extrusion pathway that controls sperm intracellular pH, and the pH-dependent flagellar Ca²(+) channel CatSper is the main pathway for Ca²(+) entry as measured by the whole-cell patch clamp technique...
  93. ncbi [Yijingfang increases the expression of CatSper1 in mice]
    Shao Bo Luo
    Department of Andrology, General Hospital of Air Force, PLA, Beijing 100142, China
    Zhonghua Nan Ke Xue 16:1047-51. 2010
    To observe the effects of Yijingfang on CatSper1 in the mouse model of cyclophosphamide-induced oligoasthenospermia.
  94. pmc A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa
    Jean Ju Chung
    1 Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children s Hospital, Boston, Massachusetts 02115, USA 2 Department of Neurobiology, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Commun 2:153. 2011
    ..Each of the CatSper1-4 genes encodes a subunit of a tetramer surrounding a Ca(2+)-selective pore, in analogy with other six-..
  95. pmc Two distinct Ca(2+) signaling pathways modulate sperm flagellar beating patterns in mice
    Haixin Chang
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Biol Reprod 85:296-305. 2011
    ..In vitro, sperm that hyperactivated during capacitation (because of activation of CATSPER plasma membrane Ca(2+) channels) developed high-amplitude pro-hook bends...
  96. ncbi [CatSper1 protein and idiopathic asthenozoospermia]
    Wen Bin Wu
    Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
    Zhonghua Nan Ke Xue 17:110-4. 2011
    To investigate the role of the cation channel of sperm 1 (CatSper1) protein in the pathogenesis of idiopathic asthenozoospermia.
  97. pmc Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa
    Xu Hui Zeng
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 108:5879-84. 2011
    ..The properties of I(Kres) suggest that it likely represents outward monovalent cation flux through CatSper channels...
  98. pmc Mathematical modeling of calcium signaling during sperm hyperactivation
    S D Olson
    Department of Mathematics, Tulane University, New Orleans, LA 70115 USA
    Mol Hum Reprod 17:500-10. 2011
    ..The major mechanism for providing Ca(2+) to the flagellum, at least in mice, are CatSper channels in the plasma membrane of the principal piece of the flagellum, because sperm from CatSper null males ..
  99. pmc Rediscovering sperm ion channels with the patch-clamp technique
    Yuriy Kirichok
    Department of Physiology, University of California San Francisco UCSF Mail Code 2140, Genentech Hall Room N272F 600 16th Street, San Francisco, CA 94158, USA
    Mol Hum Reprod 17:478-99. 2011
    ..Finally, we focus on the newly discovered sperm ion channels CatSper, KSper (Slo3) and HSper (H(v)1), identified by the sperm patch-clamp technique...
  100. pmc Coupling biochemistry and hydrodynamics captures hyperactivated sperm motility in a simple flagellar model
    Sarah D Olson
    Mathematics Department, Tulane University, 6823 St Charles Ave, New Orleans, LA 70118, USA
    J Theor Biol 283:203-16. 2011
    ..Here we present an integrative model that couples the CatSper channel mediated Ca(2+) dynamics of hyperactivation to a mechanical model of an idealized sperm flagellum in a 3-..

Research Grants11

  1. CarSpers:sperm-specific ion channels;targets for male contraceptives
    David E Clapham; Fiscal Year: 2013
    ..Male mice homozygous for null-mutations of any of the 4 CatSper genes are infertile but otherwise are completely normal...
  2. Yuriy Kirichok; Fiscal Year: 2015
    ..In Specific Aim 1, we will identify the physiological regulators of human CatSper and Hv1 channels...
  3. Gunda I Georg; Fiscal Year: 2016
    ..3. CATSPER as a Target for Male Contraception: The Cation channel of Sperm (CatSper) is involved in the regulation of ..
  4. CatSper: Novel target for an oral contraceptive
    JAYHONG CHONG; Fiscal Year: 2003
    ..D./ Ph.D., of a sperm specific ion channel, CatSper. Male mice lacking CatSper have poor sperm motility and are sterile. These and other studies carried out by Dr...
  5. SPERM ION CHANNEL REGULATION
    HARVEY FLORMAN; Fiscal Year: 2002
    ..Moreover, an understanding of the regulation of this channel is a necessary step in attempts to design channel-based contraceptive agents. ..
  6. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
    ..Controls will include fertile donors and fertile men with varicocele. ..
  7. The Protein Complex of a Sperm Ion Channel
    Dejian Ren; Fiscal Year: 2006
    ..This proposal focuses on the role of a sperm tail ion channel (CatSper1) that is specifically required for male fertility...
  8. HUMAN SPERM ZONA ACCEPTOR: ENVIRONMENTAL EFFECTS
    Susan Benoff; Fiscal Year: 2005
    ..Outcome is test of hypothesis, and possible mechanism explaining infertility associated with low sperm counts or idiopathic male infertility, tools for diagnosis, and hope for treatment. ..
  9. Annual SMRU Traveling Scholar Conference
    Susan Benoff; Fiscal Year: 2005
    ..Without this exposure, many of them would have likely pursued different career paths. ..
  10. Annual SMRU Traveling Scholars Conference
    Susan Benoff; Fiscal Year: 2006
    ..Without this exposure, many of them would have likely pursued different career paths. [unreadable] [unreadable] [unreadable] [unreadable]..
  11. Cyclic Nucleotide-Activated Calcium Channels in Sperm
    Dejian Ren; Fiscal Year: 2010
    ..This proposal focuses on the roles of a sperm tail ion channel (CatSper1) we discovered. CatSper1 from human and mice is only expressed in testis...