cathepsin L

Summary

Gene Symbol: cathepsin L
Description: cathepsin L
Alias: CATL, CTSL1, MEP, cathepsin L1, major excreted protein
Species: human

Top Publications

  1. ncbi Cloning and expression of a novel hepatitis B virus-binding protein from HepG2 cells
    S De Falco
    TECNOGEN S.C.p.A, Parco Scientifico, 81015 Piana di Monte Verna (CE, Caserta 81015, Italy
    J Biol Chem 276:36613-23. 2001
  2. doi Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis
    Jean Francois Cailhier
    Research Centre, Centre Hospitalier Universitaireé de Montréal and Montreal Cancer Institute Université de Montréal, Montreal, Quebec H2L 4M1, Canada
    J Biol Chem 283:27220-9. 2008
  3. ncbi Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis
    C Schick
    Department of Pediatrics, The Harvard Medical School, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Biochemistry 37:5258-66. 1998
  4. pmc Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
    Laszlo Herszenyi
    2nd Department of Medicine, Semmelweis University, Budapest Hungarian Academy of Science, Clinical Gastroenterology Research Unit, Budapest, Hungary
    BMC Cancer 8:194. 2008
  5. pmc Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners
    Juliette Sage
    INSERM, UMR 1100, Pathologies Respiratoires Protéolyse et Aérosolthérapie, Centre d Etude des Pathologies Respiratoires, Tours, France
    PLoS ONE 7:e43494. 2012
  6. ncbi Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts
    Olaf Zwad
    Cildren s Hospital Biochemistry, University of Hamburg, Germany
    FEBS Lett 510:211-5. 2002
  7. pmc Protease cleavage sites in HIV-1 gp120 recognized by antigen processing enzymes are conserved and located at receptor binding sites
    Bin Yu
    Department of Biomolecular Engineering, Baskin School of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA
    J Virol 84:1513-26. 2010
  8. ncbi Cathepsin L inactivates alpha 1-proteinase inhibitor by cleavage in the reactive site region
    D A Johnson
    J Biol Chem 261:14748-51. 1986
  9. ncbi Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L
    Jeffrey P Bocock
    Department of Biochemistry and Biophysics, The University of North Carolina, Chapel Hill, NC 27599 7260, USA
    Eur J Biochem 270:4008-15. 2003
  10. ncbi The crystal structure of human cathepsin L complexed with E-64
    A Fujishima
    Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, Yodogawa ku, Osaka, Japan
    FEBS Lett 407:47-50. 1997

Research Grants

  1. Drugs to Elevate Enkephalin as Novel Opiate Analgesics
    Terry Reisine; Fiscal Year: 2004
  2. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
  3. Novel Treatment Strategies for Constipation and Role of Brain-Gut axis
    SATISH SC RAO; Fiscal Year: 2011
  4. Cathepsin L in the Biosynthesis of Enkephalins and beta-Endorphin Opioid Peptides
    Steven J Bark; Fiscal Year: 2012
  5. Dietmar W Siemann; Fiscal Year: 2016
  6. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2000
  7. LYSOSOMAL PROTEASES OF SPERMATOZOA
    JOHN MC DONALD; Fiscal Year: 1993
  8. The Lysosome of Trypanosoma brucei: A Proteomic Analysis
    James D Bangs; Fiscal Year: 2012
  9. Host Factors for Hemorrhagic Fever
    JOHN NICHOLAS MISASI; Fiscal Year: 2013
  10. Inhibitors of beta-Amyloid Production in Alzheimer's
    Gregory Hook; Fiscal Year: 2007

Detail Information

Publications348 found, 100 shown here

  1. ncbi Cloning and expression of a novel hepatitis B virus-binding protein from HepG2 cells
    S De Falco
    TECNOGEN S.C.p.A, Parco Scientifico, 81015 Piana di Monte Verna (CE, Caserta 81015, Italy
    J Biol Chem 276:36613-23. 2001
    ..such as alpha-chymotrypsin and trypsin but inhibited with high potency cysteine proteases such as papain and cathepsin L. Direct binding experiments confirmed the interaction of recombinant HBV-BP with the HBV preS1 domain...
  2. doi Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis
    Jean Francois Cailhier
    Research Centre, Centre Hospitalier Universitaireé de Montréal and Montreal Cancer Institute Université de Montréal, Montreal, Quebec H2L 4M1, Canada
    J Biol Chem 283:27220-9. 2008
    ..b>Cathepsin L (CathL), a cysteine protease known to be associated with cardiovascular disease progression in animal models ..
  3. ncbi Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis
    C Schick
    Department of Pediatrics, The Harvard Medical School, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Biochemistry 37:5258-66. 1998
    ....
  4. pmc Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
    Laszlo Herszenyi
    2nd Department of Medicine, Semmelweis University, Budapest Hungarian Academy of Science, Clinical Gastroenterology Research Unit, Budapest, Hungary
    BMC Cancer 8:194. 2008
    Cathepsin B and L (CATB, CATL), urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 play an important role in colorectal cancer invasion...
  5. pmc Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners
    Juliette Sage
    INSERM, UMR 1100, Pathologies Respiratoires Protéolyse et Aérosolthérapie, Centre d Etude des Pathologies Respiratoires, Tours, France
    PLoS ONE 7:e43494. 2012
    ....
  6. ncbi Decreased intracellular degradation of insulin-like growth factor binding protein-3 in cathepsin L-deficient fibroblasts
    Olaf Zwad
    Cildren s Hospital Biochemistry, University of Hamburg, Germany
    FEBS Lett 510:211-5. 2002
    ..Analysis of fibroblasts deficient for the lysosomal cysteine protease cathepsin L (CTSL) revealed an accumulation of IGFBP-3 in the medium which was due neither to alterations in IGFBP-3 mRNA ..
  7. pmc Protease cleavage sites in HIV-1 gp120 recognized by antigen processing enzymes are conserved and located at receptor binding sites
    Bin Yu
    Department of Biomolecular Engineering, Baskin School of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA
    J Virol 84:1513-26. 2010
    ..These results suggested that HIV may have evolved to take advantage of major histocompatibility complex (MHC) class II antigen processing enzymes in order to evade or direct the antiviral immune response...
  8. ncbi Cathepsin L inactivates alpha 1-proteinase inhibitor by cleavage in the reactive site region
    D A Johnson
    J Biol Chem 261:14748-51. 1986
    The lysosomal cysteine proteinases cathepsin L and cathepsin B were examined for their effect on the neutrophil elastase inhibitory activity of human alpha 1-proteinase inhibitor (alpha 1PI)...
  9. ncbi Human proteoglycan testican-1 inhibits the lysosomal cysteine protease cathepsin L
    Jeffrey P Bocock
    Department of Biochemistry and Biophysics, The University of North Carolina, Chapel Hill, NC 27599 7260, USA
    Eur J Biochem 270:4008-15. 2003
    ..purified recombinant human testican-1 is a strong competitive inhibitor of the lysosomal cysteine protease, cathepsin L, with a Ki of 0.7 nM, but it does not inhibit the structurally related lysosomal cysteine protease cathepsin B...
  10. ncbi The crystal structure of human cathepsin L complexed with E-64
    A Fujishima
    Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, Yodogawa ku, Osaka, Japan
    FEBS Lett 407:47-50. 1997
    We have determined the three dimensional structure of the complex of human cathepsin L and E-64, an irreversible inhibitor of cysteine proteases, at 2.5 A resolution...
  11. ncbi A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor
    Brigitte Goulet
    Department of Biochemistry, McGill University, 687 Pine Avenue West, Montreal H3A 1A1, Canada
    Mol Cell 14:207-19. 2004
    ..Furthermore, few specific protein substrates for these proteases have been identified. We show here that cathepsin L functions in the regulation of cell cycle progression through proteolytic processing of the CDP/Cux ..
  12. ncbi Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells
    Aline Wille
    Institute of Immunology, Otto von Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg Germany
    Biol Chem 385:665-70. 2004
    ..The aim of the present study was to investigate the function of cathepsin L (catL) in the proteolytic network of human lung epithelial cells and its role in the regulation of apoptosis...
  13. doi Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer
    Shane Sullivan
    Centre for Colorectal Disease, St Vincent s University Hospital, Dublin, Dublin, Ireland
    Int J Cancer 125:54-61. 2009
    Previous in vitro studies have identified a nuclear isoform of Cathepsin L. The aim of this study was to examine if nuclear Cathepsin L exists in vivo and examine its association with clinical, pathological and patient outcome data...
  14. ncbi Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance
    X Xu
    Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Exp Oncol 31:102-5. 2009
    To study the expression of cathepsin L in nasopharyngeal carcinoma (NPC), and analyze its relationship with clinicopathologic factors.
  15. doi Cathepsin L, target in cancer treatment?
    Jacqueline M Lankelma
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Life Sci 86:225-33. 2010
    b>Cathepsin L, a cysteine protease, is considered to be a potential therapeutic target in cancer treatment. Proteases are involved in the development and progression of cancer...
  16. pmc Stefin B interacts with histones and cathepsin L in the nucleus
    Slavko Ceru
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana SI 1000, Slovenia
    J Biol Chem 285:10078-86. 2010
    ..The delay in cell cycle progression was associated with the inhibition of cathepsin L in the nucleus, as judged from the decreased cleavage of the CUX1 transcription factor...
  17. ncbi Cathepsin L is associated with proliferation and clinical outcome of urothelial carcinoma of the bladder
    J A Yan
    Institute of Urinary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China
    J Int Med Res 38:1913-22. 2010
    Increasing evidence suggests that the activity of cysteine proteases, including cathepsin L, is important in cancer cell invasion and metastasis...
  18. doi Inhibition of cathepsin L lowers the apoptotic threshold of glioblastoma cells by up-regulating p53 and transcription of caspases 3 and 7
    Sasa Kenig
    Department of Genetic Toxicology and Cancer Biology, National Institue of Biology, Ljubljana, Slovenia
    Apoptosis 16:671-82. 2011
    ..b>Cathepsin L inhibition was suggested as one of such modifications but the mechanism of cathepsin L anti-apoptotic activity ..
  19. pmc A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair
    Ignacio Gonzalez-Suarez
    Radiation and Cancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO, USA
    EMBO J 30:3383-96. 2011
    ..We demonstrate an unprecedented role for the cysteine protease Cathepsin L (CTSL) in the degradation of 53BP1...
  20. doi Cathepsin L is highly expressed in gastrointestinal stromal tumors
    Kohtaro Miyamoto
    Department of Organ Regulatory Surgery, Fukushima Medical University, School of Medicine, Fukushima, Japan
    Int J Oncol 39:1109-15. 2011
    ..A lysosomal cysteine proteinase termed cathepsin L has been commonly associated with malignancy in several cancer types, but this finding has not been reported ..
  21. ncbi Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1
    Kiyonari Masumoto
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, 5 1 1, Nabeshima, Saga, 849 8501, Japan
    J Biol Chem 278:45296-304. 2003
    ....
  22. ncbi Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease
    Anna Ljunggren
    Department of Laboratory Medicine, Division of Clinical Chemistry and Pharmacology, Lund University, University Hospital, SE 221 85 Lund, Sweden
    J Mol Biol 371:137-53. 2007
    ..We have crystallized and solved the structure of chagasin in complex with the host cysteine protease, cathepsin L, at 1.75 A resolution...
  23. doi Cathepsins are involved in virus-induced cell death in ICP4 and Us3 deletion mutant herpes simplex virus type 1-infected monocytic cells
    Piritta Peri
    Department of Virology, University of Turku, Kiinamyllynkatu 13, FI 20520 Turku, Finland
    J Gen Virol 92:173-80. 2011
    ..B and S activities with specific cathepsin inhibitors led to increased cell viability, and inhibition of cathepsin L activity resulted in a decreased number of apoptotic cells...
  24. ncbi Interaction between human cathepsins K, L, and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors
    Marko Novinec
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    J Biol Chem 282:7893-902. 2007
    ..Studies of enzyme partitioning between the phases showed that cathepsin K favors adsorption on elastin; cathepsin L prefers the aqueous environment, and cathepsin S is equally distributed among both phases...
  25. ncbi Cloning and expression of cathepsin L-like proteinases in the hepatopancreas of the shrimp Penaeus vannamei during the intermolt cycle
    C Le Boulay
    , Concarneau, France
    J Comp Physiol B 166:310-8. 1996
    ..two shrimp enzymes shows 70 and 52% amino acid sequence identity, respectively; 63% identity is shown with rat cathepsin L. Northern hybridization analysis showed the same size for the different cysteine protease transcripts in ..
  26. ncbi Rat epidermal cathepsin L-like proteinase: purification and some hydrolytic properties toward filaggrin and synthetic substrates
    A Kawada
    Department of Dermatology, National Defense Medical College, Saitama
    J Biochem 118:332-7. 1995
    We have purified cathepsin L-like proteinase from rat epidermis, determined its NH2-terminal amino acid sequence, and investigated its proteolytic activities on an intermediate filament-associated protein filaggrin and several synthetic ..
  27. ncbi Leishmania major: comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids
    J A Sakanari
    Department of Pathology, University of California, V A Medical Center, San Francisco 94121, USA
    Exp Parasitol 85:63-76. 1997
    ..One of the genes is structurally similar to the cathepsin L-like family and the other is similar to the cathepsin B-like family of cysteine proteases. The L...
  28. ncbi Characterisation of Tc-cpl-1, a cathepsin L-like cysteine protease from Toxocara canis infective larvae
    A Loukas
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Mol Biochem Parasitol 92:275-89. 1998
    ..TEX proteases readily cleaved the cathepsin L- and B-specific peptide substrate Z-Phe-Arg-AMC and to a lesser extent, the cathepsin B-specific peptide Z-Arg-..
  29. ncbi 3-hydroxy-3-methylglutaryl coenzyme A reductase is sterol-dependently cleaved by cathepsin L-type cysteine protease in the isolated endoplasmic reticulum
    T Moriyama
    Research Institute for Food Science, Kyoto University, Gokasho, Japan
    Arch Biochem Biophys 386:205-12. 2001
    ..use of various protease inhibitors suggested that degradation of HMG-CoA reductase in vitro is catalyzed by a cathepsin L-type cysteine protease...
  30. ncbi Cloning and expression of a rat placental cDNA encoding a novel cathepsin L-related protein
    P R Conliffe
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville 32610, USA
    Mol Reprod Dev 40:146-56. 1995
    b>Cathepsin L is a major lysosomal cysteine protease produced by mouse placenta and fibroblasts. This study characterizes a novel cathepsin L-related mRNA expressed in rat placenta...
  31. ncbi Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization
    D Bromme
    Department of Human Genetics, Mount Sinai School of Medicine, CUNY, New York 10029, USA
    Biochemistry 38:2377-85. 1999
    ..In contrast to cathepsin L, but similar to cathepsin S, cathepsin V exhibited only a very weak collagenolytic activity...
  32. ncbi Regulation of collagenolytic cysteine protease synthesis by estrogen in osteoclasts
    N Furuyama
    Discovery Research Laboratory, Takeda Chemical Industries, Ltd, 17 85, Juso honmachi 2 chome, Yodogawa ku, 532 8686, Osaka, Japan
    Steroids 65:371-8. 2000
    ..In Ovx mice, though the amount of cathepsin L increased more than that of cathepsin K, cathepsin K and cathepsin L content increased by 200-400% compared ..
  33. ncbi The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles
    Sascha Hagemann
    Institut für Molekulare Medizin und Zellforschung, Universitat Freiburg, Freiburg, Germany
    Eur J Cell Biol 83:775-80. 2004
    Mice lacking the ubiquitously expressed lysosomal cysteine protease cathepsin L, show a complex skin phenotype consisting of periodic hair loss and epidermal hyperplasia with hyperproliferation of basal epidermal keratinocytes, ..
  34. doi Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells
    Hiroaki Yoshii
    Department of AIDS Research, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Virology 394:227-34. 2009
    ..How did CA-074Me attenuate the Eco-MLV infection? The CA-074Me treatment of NIH3T3 cells inhibited cathepsin L activity, and a cathepsin L specific inhibitor, CLIK148, attenuated the Eco-MLV vector infection...
  35. doi Single nucleotide polymorphisms in several porcine cathepsin genes are associated with growth, carcass, and production traits in Italian Large White pigs
    V Russo
    Dipartimento di Protezione e Valorizzazione Agroalimentare, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, 42100 Reggio Emilia, Italy
    J Anim Sci 86:3300-14. 2008
    ..encoding for lysosomal proteinases (cathepsin B, CTSB; cathepsin D, CTSD; cathepsin F, CTSF; cathepsin H, CTSH; cathepsin L, CTSL; and cathepsin Z, CTSZ) and for a cathepsin inhibitor (cystatin B) were investigated...
  36. ncbi A selective colorimetric assay for cathepsin L using Z-Phe-Arg-4-methoxy-beta-naphthylamide
    R C Kamboj
    Department of Chemistry, Kurukshetra University, Haryana, India
    Biochimie 75:873-8. 1993
    ..4.22.1), cathepsin H (EC 3.4.22.16) and cathepsin L (EC 3.4.22...
  37. ncbi Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells
    Daniel H Ebert
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:24609-17. 2002
    ..Infection of both L929 cells treated with the cathepsin L inhibitor Z-Phe-Tyr(t-Bu)-diazomethyl ketone and cathepsin L-deficient mouse embryo fibroblasts resulted in ..
  38. ncbi Evidence for cross-talk between Sertoli and germ cells using selected cathepsins as markers
    S S Chung
    Population Council, Center for Biomedical Research, New York, New York, USA
    J Androl 19:686-703. 1998
    ..during spermatogenesis, in situ hybridization was used to localize messenger RNA (mRNA) transcripts of cathepsin L, D, and S in the epithelium at different stages of the spermatogenic cycle in the rat...
  39. ncbi Basis for low affinity binding of a lysosomal cysteine protease to the cation-independent mannose 6-phosphate receptor
    J M Dong
    Department of Physiology, School of Medicine and Veterinary Medicine, Tufts University, Boston, Massachusetts 02111
    J Biol Chem 265:4210-7. 1990
    In cultured mouse fibroblasts, secretion of the lysosomal cysteine protease, MEP (major excreted protein) is regulated by growth factors and viral transformation...
  40. ncbi Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease
    J B Cornelissen
    Institute for Animal Science and Health ID Lelystad, Department of Immunology, Pathobiology and Epidemiology, PO Box 65, 8200 AB, Lelystad, The Netherlands
    Int J Parasitol 31:728-37. 2001
    A diagnostic ELISA with recombinant Fasciola hepatica cathepsin L-like protease as antigen was developed to detect antibodies against F. hepatica in sheep and cattle...
  41. pmc Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides
    Lydiane Funkelstein
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropeptides 44:457-66. 2010
    ..This review describes recent findings indicating the prominent role of cathepsin L in secretory vesicles for production of neuropeptides from their protein precursors...
  42. ncbi The amino acid sequences, structure comparisons and inhibition kinetics of sheep cathepsin L and sheep stefin B
    A Ritonja
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Jamova, Ljubljana, Slovenija
    Comp Biochem Physiol B Biochem Mol Biol 114:193-8. 1996
    b>Cathepsin L and stefin B were isolated from sheep liver, the cathepsin L being isolated by a low pH homogenisation method, which increases the proportion of the two-chain form of the enzyme, thus facilitating sequencing...
  43. ncbi Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines
    John P Dalton
    Molecular Parasitology Unit, School of Biotechnology, 9, Dublin, Ireland
    Int J Parasitol 33:1173-81. 2003
    ..The major proteases, cathepsin L1 (FheCL1) and cathepsin L2 (FheCL2) are members of a lineage that gave rise to the human cathepsin Ls, Ks and Ss,..
  44. ncbi Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin l2
    D Bernard
    L Oreal Recherche, Clichy, France
    J Invest Dermatol 120:592-600. 2003
    ..clear evidence that this new protease, despite its membership to the cathepsin-L-like family, is distinct from cathepsin L and from the recently described stratum corneum thiol protease...
  45. ncbi Expression and localization of cathepsin k in adult rat sertoli cells
    Matthew D Anway
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Biol Reprod 70:562-9. 2004
    ..b>Cathepsin L is a major secretory product of rat and mouse Sertoli cells, the absence of which in furless mice is associated ..
  46. pmc Dependence of cathepsin L-induced coronary endothelial dysfunction upon activation of NAD(P)H oxidase
    Fan Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th, Richmond, VA 23298, USA
    Microvasc Res 78:45-50. 2009
    b>Cathepsin L is a cysteine protease that can generate endogenous endostatin in vascular and epithelial basement membranes and importantly participates in a variety of pathophysiological processes...
  47. ncbi Molecular and enzymatic properties of a cathepsin L-like proteinase with distinct substrate specificity from northern shrimp (Pandalus borealis)
    H Aoki
    Laboratory of Aquatic Molecular Biology and Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, 113 8657 Tokyo, Japan
    J Comp Physiol B 174:59-69. 2004
    We purified a cathepsin L-like proteinase to homogeneity from the hepatopancreas of northern shrimp Pandalus borealis by several chromatographic procedures...
  48. ncbi Developmental expression of cathepsin L and c-rasHa in the mouse placenta
    R T Hamilton
    Department of Zoology and Genetics, Iowa State University, Ames 50011 3223
    Mol Reprod Dev 30:285-92. 1991
    An investigation is described of the expression of the cysteine proteinase cathepsin L during placental development...
  49. ncbi Existence of cathepsin L and its characterization in red bulleye surimi
    Yaqin Hu
    Laboratory of Aquatic Product Utilization, Graduate School of Agriculture, Kochi University, Nankoku, Kochi, 783 8502, Japan
    Pak J Biol Sci 10:78-83. 2007
    b>Cathepsin L could not be removed completely during conventional actomyosin extraction and still remained in the actomyosin of red bulleye surimi...
  50. ncbi Cathepsin L gene expression and promoter activation in rodent granulosa cells
    Venkataraman Sriraman
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Place, Houston, TX 77030, USA
    Endocrinology 145:582-91. 2004
    The cysteine protease cathepsin L exhibits hormone-regulated expression during ovulation...
  51. ncbi Characterization of a cathepsin L-associated protein in Artemia and its relationship to the FAS-I family of cell adhesion proteins
    Alden H Warner
    Department of Biological Sciences, University of Windsor, Windsor, Ontario, Canada
    Eur J Biochem 271:4014-25. 2004
    ..5 kDa) with a high degree of homology with cathepsin L, and a noncatalytic subunit (31.5 kDa) of unknown function...
  52. doi Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration
    Yolanda M Fortenberry
    Department of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1800:580-90. 2010
    ..However, the physiological role of PCI remains under investigation. The cysteine protease, cathepsin L, has a role in many physiological processes including cardiovascular diseases, blood vessel remodeling, and ..
  53. doi Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors
    Rajesh T Shenoy
    Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore
    J Struct Biol 173:14-9. 2011
    b>Cathepsin L plays a key role in many pathophysiological conditions including rheumatoid arthritis, tumor invasion and metastasis, bone resorption and remodeling...
  54. doi Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy
    Xin Zheng
    Children s Memorial Research Center, Children s Memorial Hospital, Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Biochim Biophys Acta 1783:2294-300. 2008
    ..which recombinant pro-death proteases (caspase-3 or cathepsin D) were incubated with the pro-survival protease (cathepsin L) in their respective optimal conditions and determined the effects of these reactions on enzyme integrity and ..
  55. doi Association between cathepsin L (CTSL) and cathepsin S (CTSS) polymorphisms and meat production and carcass traits in Italian Large White pigs
    L Fontanesi
    DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
    Meat Sci 85:331-8. 2010
    The aim of this work was to identify and analyse DNA markers in two cathepsin genes, cathepsin L (CTSL) and cathepsin S (CTSS), and study their association with meat quality parameters (including cathepsin activity of post mortem muscle) ..
  56. doi Adult and juvenile Fasciola cathepsin L proteases: different enzymes for different roles
    Luke J Norbury
    School of Applied Sciences, RMIT University, Bundoora West Campus, Plenty Road, Bundoora, Victoria 3083, Australia
    Biochimie 93:604-11. 2011
    ..are promising vaccine or drug targets for prophylaxis or therapy against Fasciola parasites which express cathepsin L and B proteases during their development...
  57. ncbi Anti-cathepsin L monoclonal antibodies that distinguish cathepsin L from cathepsin V
    N Kopitar-Jerala
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Biol Chem 382:867-70. 2001
    b>Cathepsin L is a lysosomal cysteine protease involved in intracellular protein degradation. Recently, several new cysteine proteases have been identified...
  58. ncbi Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation
    Brigitte Goulet
    Molecular Oncology Group, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Mol Cancer Res 5:899-907. 2007
    It is generally accepted that the role of cathepsin L in cancer involves its activities outside the cells once it has been secreted...
  59. pmc Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies
    Margery C Beinfeld
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, United States
    Peptides 30:1882-91. 2009
    ..This study demonstrates the significant role of the cysteine protease cathepsin L for CCK8 production...
  60. doi Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice
    Lisa Sevenich
    Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Stefan Meier Strasse 17, Freiburg, D 79104, Germany
    Biochimie 92:1674-80. 2010
    A genetic deficiency of the cysteine protease cathepsin L (Ctsl) in mice results in impaired positive selection of conventional CD4+ T helper cells as a result of an incomplete processing of the MHC class II associated invariant chain or ..
  61. doi Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum
    Natthawan Kongkerd
    Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Mol Biochem Parasitol 160:129-37. 2008
    ..In this study, we identified a cDNA encoding a cathepsin L-like cysteine protease (GsCL1) from the lambdaZAP cDNA library of G...
  62. ncbi Spinal cord blood supply in patients with thoracoabdominal aortic aneurysms
    Michael J Jacobs
    Department of Surgery, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    J Vasc Surg 35:30-7. 2002
    ..This study was performed for the prospective documentation of patent segmental arteries during TAAA repair and the assessment of their functional contribution to the spinal cord blood supply...
  63. ncbi [Experimental study of biocompatibility of LIFEs in peripheral fascicles]
    Xiu jun Zheng
    Orthopedic Department, Zhong Shan Hospital Affiliated to FuDan University, Shanghai 200032, China
    Zhonghua Yi Xue Za Zhi 83:2152-7. 2003
    ..And to discuss the possibility of peripheral fascicular signals as a new signal source to control an electronic prosthetic hand...
  64. ncbi Do motor evoked potentials allow quantitative assessment of motor function in patients with spinal cord lesions?
    B Meyer
    Department of Neurosurgery, University of Tubingen, Federal Republic of Germany
    Eur Arch Psychiatry Clin Neurosci 241:201-4. 1992
    Motor evoked potentials (MEP) were recorded in a total of 110 patients with tumorous (n = 39) and non-tumorous (n = 71) lesions of the cervical (n = 59), thoracic (n = 37) and thoracolumbar (n = 14) spinal cord...
  65. ncbi Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma
    Marco Niedergethmann
    Department of Surgery, University Hospital Mannheim, University of Heidelberg, Germany
    Pancreas 29:204-11. 2004
    ....
  66. doi The effects of the neuromuscular blockade levels on amplitudes of posttetanic motor-evoked potentials and movement in response to transcranial stimulation in patients receiving propofol and fentanyl anesthesia
    Yuri Yamamoto
    Department of Anesthesiology, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Anesth Analg 106:930-4, table of contents. 2008
    ..We conducted the present study to determine an appropriate level of neuromuscular blockade during the monitoring of p-MEPs with a focus on patient movement...
  67. ncbi [Neurophysiological assessment in patients with clinically defined multiple sclerosis with special reference to P300 wave study]
    M F Casanova-González
    Departamento de Neurofisiologia Clinica, Hospital Paquito González, Habana, Cuba
    Rev Neurol 29:1134-7. 1999
    ..Study of the P300 wave is a positive component of long latency related to cognitive function: amplitude with attention, and latency with the ability to process information...
  68. pmc Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression
    Lydiane Funkelstein
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 283:35652-9. 2008
    ..Key findings from this study show that cathepsin L functions as a major proteolytic enzyme for the production of POMC-derived peptide hormones in secretory ..
  69. ncbi Clear Tinnitus, middle-ear pressure, and tinnitus relief: a prospective trial
    Barbara Goldstein
    Department of Otolaryngology, Health Science Center at Brooklyn, State University of New York, Downstate Medical Center, Brooklyn, USA
    Int Tinnitus J 13:29-39. 2007
    ..Our goal was to establish the efficacy, in a 12-week period, of Clear Tinnitus for tinnitus relief in patients with tinnitus of the severe, disabling type...
  70. ncbi [A randomized controlled trial study of pulmonary rehabilitation with respiratory physiology as the guide on prognosis in patients with chronic obstructive pulmonary disease]
    Zai qi Zhang
    Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510120, Guangdong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 20:607-10. 2008
    ..To observe the effect of pulmonary rehabilitation with respiratory physiology as guide in patients with chronic obstructive pulmonary disease (COPD)...
  71. pmc Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells
    Yoshio Mori
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Virol 81:8477-87. 2007
    ..The small capsid protein was shown to be generated by processing with host cysteine protease cathepsin L. An in vitro cleavage assay revealed that cathepsin L cleaves the capsid protein between amino acid residues ..
  72. pmc The prevention of neural complications in the surgical treatment of scoliosis: the role of the neurophysiological intraoperative monitoring
    F Pastorelli
    Servizio di Neurofisiopatologia, Istituti Ortopedici Rizzoli, Bologna, Italy
    Eur Spine J 20:S105-14. 2011
    ..The importance of combined somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) monitoring during spine surgery is well known...
  73. ncbi Visual and motor evoked potentials in the course of multiple sclerosis
    P Fuhr
    Department of Neurology, University of Basel, Switzerland
    Brain 124:2162-8. 2001
    ..To validate the visual and motor evoked potentials (VEP and MEP) as measures for the course of multiple sclerosis, we examined prospectively 30 patients with relapsing-remitting ..
  74. doi Analysis of motor and somatosensory evoked potentials during thoracic and thoracoabdominal aortic aneurysm repair
    Kourosh Keyhani
    Cardiothoracic and Vascular Surgery, University of Texas Medical School Houston, Houston, Texas, USA
    J Vasc Surg 49:36-41. 2009
    Use of motor evoked potentials (MEP) and somatosensory evoked potentials (SSEP) monitoring during thoracic and thoracoabdominal aortic surgery is controversial...
  75. ncbi [Pathophysiology of carbohydrate-deficient glycoprotein syndrome--neuroradiological and neurophysiological study]
    M Tayama
    Department of Pediatrics, School of Medicine University of Tokushima
    No To Hattatsu 25:537-42. 1993
    ..The all cases showed the normal pattern for VEP and MEP. All showed cerebellar hypoplasia and various degree of pontine hypoplasia on MRI...
  76. ncbi The role of sensory and motor evoked potentials in the prognosis of Pott's paraplegia
    U K Misra
    Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareily Road, Lucknow 26014, India
    Clin Neurophysiol 115:2267-73. 2004
    ..In view of paucity of evoked potential changes in Pott's paraplegia, it is proposed to evaluate the role of motor and somatosensory evoked potentials in predicting the outcome...
  77. ncbi The analgesic efficacy and safety of intra-articular morphine and mepivicaine following temporomandibular joint arthroplasty
    John R Zuniga
    Department of Surgery, Division of Oral and Maxillofacial Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Oral Maxillofac Surg 65:1477-85. 2007
    ..This study was designed to evaluate the efficacy and safety of intra-articular morphine, mepivacaine, or a combination of both in the management of temporomandibular joint (TMJ) pain in a 24-hour period after arthroplasty...
  78. ncbi An account of cloned genes of Methyl-erythritol-4-phosphate pathway of isoprenoid biosynthesis in plants
    Deepak Ganjewala
    School of Biotechnology, Chemical and Biomedical Engineering, VIT University, Vellore 632 014 T N, India
    Curr Issues Mol Biol 11:i35-45. 2009
    ..Generally, plants use two separate pathways plastidial Methyl-erythritol-4-phosphate (MEP) and cytosolic acetate-mevalonate (MVA) pathways for formation of IPP...
  79. pmc Exposure to phthalates and breast cancer risk in northern Mexico
    Lizbeth Lopez-Carrillo
    National Institute of Public Health, Cuernavaca, Morelos, Mexico
    Environ Health Perspect 118:539-44. 2010
    ..Phthalates, ubiquitous environmental pollutants that may disturb the endocrine system, are used primarily as plasticizers of polyvinyl chloride and as additives in consumer and personal care products...
  80. doi Changes of excitability in M1 induced by neuromuscular electrical stimulation differ between presence and absence of voluntary drive
    Kenichi Sugawara
    Division of Physical Therapy, Faculty of Health and Social Work, Kanagawa University of Human Services, Heisei cho, Yokosuka, Kanagawa, Japan
    Int J Rehabil Res 34:100-9. 2011
    ..In resting muscle states, an increase in TES intensity resulted in an increase in MEP ratio in both the muscles...
  81. ncbi Motor evoked potentials from the pelvic floor
    Søren Brostrøm
    Department of Obstetrics and Gynecology, Glostrup County Hospital, University of Copenhagen, Denmark
    Neurourol Urodyn 22:620-37. 2003
    ..To resolve the lack of methodological clarity and the need for normative values for the use of pelvic floor motor evoked potentials (MEPs), 30 healthy women and 16 women with MS were studied...
  82. ncbi Motor evoked potentials (MEP) and evoked pressure curves (EPC) from the urethral compressive musculature (UCM) by functional magnetic stimulation in healthy volunteers and patients with neurogenic incontinence
    Daniel M Schmid
    Swiss Paraplegic Centre Paracare, Institute for Rehabilitation and Research, University Hospital Balgrist, Zurich, Switzerland
    Neurourol Urodyn 24:117-27. 2005
    ..of this study is to assess neurogenic lesions of the somatomotor efferent nervous pathway to the urethral compressive musculature (UCM) by means of motor evoked potentials (MEP) and simultaneously recorded evoked pressure curves (EPC).
  83. ncbi Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis
    Roy Mathew
    Schneider s Children s Hospital, Division of Nephrology, SCH 365, 269 01 76th Ave, New Hyde Park, NY 11040 1432, USA
    Am J Physiol Renal Physiol 289:F911-21. 2005
    Meprin (MEP) A is a metalloendopeptidase that is present in the renal proximal tubule brush-border membrane (BBM) and that colocalizes with angiotensin-converting enzyme (ACE)...
  84. ncbi Accessory nerve electroneurography by magnetic stimulation in normal subjects
    R Barona
    Department of Otolaryngology, Valencia University General Hospital, Spain
    Acta Otorhinolaryngol Belg 47:347-50. 1993
    ..The motor evoked potential (MEP) obtained by magnetic stimulation at the skull base exhibited greater latency and amplitude than that recorded by ..
  85. ncbi [Protocol of intraoperative neurophysiological spinal cord monitoring]
    C Franco Carcedo
    , , Madrid,
    Rev Neurol 28:583-7. 1999
    ..at late 70's, as a method to monitorize spinal cord function during surgery; years later, motor evoked potentials (MEP) joined this option, giving us direct information about the functioning of posterior spinothalamic tract (posterior ..
  86. ncbi [Investigation of corticospinal dysfunction in multiple sclerosis and motoneuron diseases using motor evoked potentials]
    L Gómez-Fernández
    Laboratorio de Neurofisiologia Clinica, Centro Internacional de Restauracion Neurologica, Ciudad de La Habana, Cuba
    Rev Neurol 24:1507-12. 1996
    The introduction of motor evoked potentials (MEP) into neurological practice has been very useful in the study of motor disorders, especially in patients with motor neurone diseases (MND) and multiple sclerosis (MS).
  87. ncbi Motor evoked potential monitoring during upper cervical spine surgery
    H Kitagawa
    Department of Orthopedic Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Spine (Phila Pa 1976) 14:1078-83. 1989
    Motor evoked potential (MEP) produced by transcranial electrical stimulation was recorded from an epidural electrode in 20 consecutive patients during upper cervical spine surgery...
  88. ncbi Purification and properties of embryonic cysteine proteinase which participates in yolk-lysis of Xenopus laevis
    N Yoshizaki
    Department of Biological Diversity and Resources, Faculty of Agriculture, Gifu University, Japan
    Comp Biochem Physiol B Biochem Mol Biol 119:571-6. 1998
    ..Its activity was inhibited by Z-Phe-Phe-CHN2, a specific cathepsin L inhibitor, as well as by leupeptin and E-64...
  89. ncbi Role of primary sensorimotor cortices in generating inhibitory motor response in humans
    A Ikeda
    Department of Brain Pathophysiology, and Neurology, Kyoto University School of Medicine, Japan
    Brain 123:1710-21. 2000
    ..The results showed that (i) in all subjects, single pulse stimulation of MI-SI elicited a motor evoked potential (MEP) followed by a silent period (SP) in the contralateral distal hand muscles, the latter lasting 300 ms after the ..
  90. ncbi Effect of promoters on cellular immune response induced by recombinant fowlpox virus expressing multi-epitope polypeptides from HIV-1
    Dania Vázquez-Blomquist
    División de Vacunas, Centro de Ingenieria Genetica y Biotecnologia, Apdo 6162, Ciudad Habana 10600, Cuba
    Biotechnol Appl Biochem 36:171-9. 2002
    ..We have shown previously that a recombinant fowlpox virus (rFWPV), expressing the multi-epitope polypeptide (MEP) from HIV-1 TAB9, induces strong and protective Th1 and CTL responses in Balb/c mice...
  91. ncbi Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes
    Tohru Dairi
    Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Kosugi Machi, Toyama 939 0398, Japan
    J Antibiot (Tokyo) 58:227-43. 2005
    Most Streptomyces strains are equipped with only the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for the formation of isopentenyl diphosphate, a common precursor of isoprenoids...
  92. doi Nonequilibrium thermodynamics and maximum entropy production in the Earth system: applications and implications
    Axel Kleidon
    Max Planck Institut für Biogeochemie, Postfach 10 01 64, 07701 Jena, Germany
    Naturwissenschaften 96:653-77. 2009
    ..The proposed principle of maximum entropy production (MEP) states that systems are driven to steady states in which they produce entropy at the maximum possible rate given ..
  93. ncbi IgG aggregate removal by charged-hydrophobic mixed mode chromatography
    Pete Gagnon
    Validated Biosystems, San Clemente, CA 92672, USA
    Curr Pharm Biotechnol 10:434-9. 2009
    ..This review focuses on the two members of this family that have shown the most promise for aggregate removal: MEP HyperCel() and Capto() adhere...
  94. doi A new paradigm for ammonia excretion in aquatic animals: role of Rhesus (Rh) glycoproteins
    Patricia A Wright
    Department of Integrative Biology, University of Guelph, Guelph, ON, N1G 2W1, Canada
    J Exp Biol 212:2303-12. 2009
    ..recent discovery of the ammonia-transporting function of the Rhesus (Rh) proteins, a family related to the Mep/Amt family of methyl ammonia and ammonia transporters in bacteria, yeast and plants, and the occurrence of these ..
  95. doi Alteration of cortical excitability in patients with fibromyalgia
    Alaa Mhalla
    INSERM U 987, CHU Ambroise Pare, APHP, Boulogne Billancourt, France
    Pain 149:495-500. 2010
    ..Single-pulse stimulation was used for measurements of the rest motor threshold (RMT) and suprathreshold MEP. Paired-pulse stimulation was used to assess short intracortical inhibition (SICI) and intracortical facilitation (..
  96. doi Intraoperative tractography and motor evoked potential (MEP) monitoring in surgery for gliomas around the corticospinal tract
    Satoshi Maesawa
    Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    World Neurosurg 74:153-61. 2010
    Our goal is to indicate the importance of combining intraoperative tractography with motor-evoked potential (MEP) monitoring for glioma surgery in motor eloquent areas.
  97. doi Development and evaluation of a bio-ion measurement system on acupoints for meridian diagnosis
    Soo Byeong Kim
    Eastern and Western Biomedical System Laboratory, Department of Biomedical Engineering, Yonsei University, Wonju, Republic of Korea
    J Acupunct Meridian Stud 6:110-8. 2013
    The aim of this study was to develop a new method of measuring the meridian energy potential (MEP) at an acupoint with bioelectrical impedance in order to establish an objective meridian diagnosis...
  98. doi Comparison of the Wake-up Test and Combined TES-MEP and CSEP Monitoring in Spinal Surgery
    Bailing Chen
    Department of Spine Surgery, 1st Affiliated Hospital of Sun Yat sen University Department of Spine Surgery, 3rd Affiliated Hospital of Southern Medical University Department of Anesthesiology, 1st Affiliated Hospital of Sun Yat sen University, Guangzhou, China
    J Spinal Disord Tech 28:335-40. 2015
    ..A retrospective clinical analysis...
  99. pmc A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis
    Wesley Wu
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA
    Antimicrob Agents Chemother 59:356-64. 2015
    ..falciparum IspD, an enzyme in the MEP (methyl-d-erythritol-4-phosphate) isoprenoid precursor biosynthesis pathway in the apicoplast...
  100. doi Molecular structure, FT-IR, FT-Raman, NBO, HOMO and LUMO, MEP, NLO and molecular docking study of 2-[(E)-2-(2-bromophenyl)ethenyl]quinoline-6-carboxylic acid
    Rajeev T Ulahannan
    Department of Physics, TKM College of Arts and Science, Kollam, Kerala, India
    Spectrochim Acta A Mol Biomol Spectrosc 151:184-97. 2015
    ..b>MEP was performed by the DFT method and the predicted infrared intensities and Raman activities have also been reported...
  101. ncbi Isoflurane plus nitrous oxide versus propofol for recording of motor evoked potentials after high frequency repetitive electrical stimulation
    U Pechstein
    Department of Neurosurgery, University of Bonn, Germany
    Electroencephalogr Clin Neurophysiol 108:175-81. 1998
    ..this study was to test the influence of two widespread techniques of general anesthesia on motor evoked potentials (MEP) in response to transcranial and direct cortical high frequency repetitive electrical stimulation...

Research Grants65

  1. Drugs to Elevate Enkephalin as Novel Opiate Analgesics
    Terry Reisine; Fiscal Year: 2004
    ..in secretory vesicles for the generation of enkephalin, and it has been demonstrated as the cysteine protease cathepsin L. Cathepsin L cleaves at appropriate proenkephalin processing sites, is colocalized with enkephalin in secretory ..
  2. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..affinity labeling and peptide microsequencing by mass spectrometry to identify the responsible PTP activity as cathepsin L. Cathepsin L is colocalized in secretory vesicles with enkephalin, and cathepsin L cleaves enkephalin-..
  3. Novel Treatment Strategies for Constipation and Role of Brain-Gut axis
    SATISH SC RAO; Fiscal Year: 2011
    ..evoked potentials (CEP) after electrical stimulation of the anorectum (afferent) and the motor evoked potentials (MEP) following transcranial magnetic stimulation (efferent)...
  4. Cathepsin L in the Biosynthesis of Enkephalins and beta-Endorphin Opioid Peptides
    Steven J Bark; Fiscal Year: 2012
    ..Secretory vesicle Cathepsin L has recently been discovered as a new and significant protease pathway for production of enkephalins and beta-..
  5. Dietmar W Siemann; Fiscal Year: 2016
    ..proposal is focused on therapeutically targeting a key player in the metastatic cascade;the cysteine protease cathepsin L (CTSL)...
  6. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2000
    ..Recently, a cathepsin L-like enzyme and another member of the cystatin family were cloned, suggesting that the role of cysteine ..
  7. LYSOSOMAL PROTEASES OF SPERMATOZOA
    JOHN MC DONALD; Fiscal Year: 1993
    ..One of the endopeptidases resembles lysosomal cathepsin L, but is totally masked in epididymal sperm...
  8. The Lysosome of Trypanosoma brucei: A Proteomic Analysis
    James D Bangs; Fiscal Year: 2012
    ..brucei, p67 an essential membrane glycoprotein [6, 8], the a cathepsin L orthologue, TbCatL [1, 9], and a cathepsin B orthologue, TbCatB [10]...
  9. Host Factors for Hemorrhagic Fever
    JOHN NICHOLAS MISASI; Fiscal Year: 2013
    ..His discovery that the proteases cathepsin B &L (Cat B, CatL) are critical to entry of EboV was the first to describe the use of lysosomal proteases as host factors for ..
  10. Inhibitors of beta-Amyloid Production in Alzheimer's
    Gregory Hook; Fiscal Year: 2007
    ..majority of beta-amyloid via the regulated secretory pathway and that the cysteine proteases, cathepsin B and cathepsin L, are the beta- secretases of that pathway...
  11. SUSANA GONZALO HERVAS; Fiscal Year: 2014
    ..Our preliminary data indicates that 53BP1 is degraded by the protease Cathepsin L and by the proteasome...
  12. Isolation of a cervical cancer tumor suppressor gene
    Eri S Srivatsan; Fiscal Year: 2012
    ..Further, normal and CINs containing cystatin E/M showed reduced expression of the lysosomal protease cathepsin L. However, overexpression of cathepsin L was observed in tumors pointing to an inverse relationship between the ..
  13. Modeling viral entry and its inhibition using SARS-CoV
    Graham Simmons; Fiscal Year: 2012
    ..determined that the spike envelope glycoprotein of SARS-CoV (termed S) requires proteolytic processing by cathepsin L, and likely other proteases, in order to facilitate its membrane fusion potential...
  14. Silvia N Moreno; Fiscal Year: 2016
    ..Furthermore, as plant vacuoles, the PLV also contains proteases such as cathepsin L (TgCPL) and others...
  15. A novel vacuolar compartment in Toxoplasma gondii
    Silvia N Moreno; Fiscal Year: 2010
    ..The localization of a cathepsin L (CPL) in this compartment supports its postulated role in processing of M2AP...
  16. Jochen Reiser; Fiscal Year: 2015
    ..proteinuria and kidney disease progression can be specifically induced by the action of a novel cytosolic cathepsin L variant (cCatL)...
  17. The Role of Snail Signaling in Prostate Cancer Metastasis
    Valerie Odero-Marah; Fiscal Year: 2013
    ..Since Snail is not required by adult cells except during injury, targeting Snail that is mainly expressed by cancer cells may antagonize metastatic lesions in bone without affecting normal bone in other areas of the body. ..
  18. Nanoparticle targeting of cathepsin-L inhibitor and doxorubicin in breast cancer
    Shaker Mousa; Fiscal Year: 2007
    ..Recent reports provide a persuasive rationale for studying the role of cathepsin L in the process of chemotherapeutic drug resistance...
  19. Stage-Specific Germ Cell-Sertoli Cell Interactions
    William Wright; Fiscal Year: 2007
    ..and biological consequences of stage-specific gene expression by Sertoli cells from the perspective of the cathepsin L gene...
  20. Proenkephalin Processing for Biosynthesis of Enkephalin Peptide Neutrotransmitter
    WEIYA LU; Fiscal Year: 2009
    ..Recent findings have indicated a key role for secretory vesicle cathepsin L in processing PE to active enkephalin peptides...
  21. DEMONSTRATION OF CATHEPSIN FUNCTION IN TUMOR METASTASIS
    GARABED SAHAGIAN; Fiscal Year: 2000
    ..displayed generalized secretion of cathepsins and other lysosomal proteins, while another line (4T07) secreted cathepsin L selectively...
  22. CHARACTERIZATION OF A TRYPANSOMA BRUCEI PROTEASE
    Eric Pamer; Fiscal Year: 1991
    ..The protease has a substrate preference that is most similar to mammalian cathepsin L and is contained in the trypanosomal lysosome...
  23. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2005
    ..Recently, a cathepsin L-Iike enzyme and another member of the cystatin family were cloned, suggesting that the role of cysteine ..
  24. Assessing Workplace Phthalate Exposures Among Massage Therapy Students
    VICTORIA PAK; Fiscal Year: 2010
    ..of massage therapist students to phthalates in the work setting;2)To determine the levels of the urinary biomarkers MEP and MBP, the main metabolites of Diethyl Phthalate (DEP) and Dibutyl Phthalate (DBP) in massage therapist students, ..
  25. Craig T Morita; Fiscal Year: 2016
    ..species have been used for cancer vaccines but differ significantly since the Gram negative Salmonella uses the MEP pathway and is given orally whereas the Gram positive Listeria uses both the MEP and mevalonate pathways and is ..
  26. Donald T Moir; Fiscal Year: 2014
    ..Gr(-) nonfermenters, utilize an alternate isoprenoid synthesis pathway, the 2-C- methyl-D-erythritol 4-phosphate (MEP) pathway, which is quite distinct from that found in humans, the mevalonate (MVA) pathway, and provides a high ..
  27. GENETIC STUDIES OF GLUTAMINE SYNTHETASE IN BACTERIA
    SYDNEY GOVONS KUSTU; Fiscal Year: 2010
    ..In a broader context, Amt proteins (called Mep in some organisms) are found widely in microbes, vascular plants, and invertebrate animals and are the first ..
  28. AUDREY RAGAN ODOM; Fiscal Year: 2016
    ..P. falciparum possesses an essential metabolic pathway, non-mevalonate isoprenoid biosynthesis (the MEP pathway), which is not present in humans...
  29. DEFINITION OF MICROENVIRONMENT IN BREAST CANCER
    Mina Bissell; Fiscal Year: 2013
    ..evidence, that in traditional cell culture conditions, purified LEPs almost immediately develop a hybrid LEP/MEP phenotype acquiring aspects of MEP gene expression and in particular developing the tumor suppressor functions ..
  30. Targeting DXP Synthase in Non-mammalian Isoprenoid Biosynthesis
    FRANCINE M MORRIS; Fiscal Year: 2012
    ..utilize a pathway for isoprenoid biosynthesis that is absent in mammals known as the methylerythritol phosphate (MEP) pathway...
  31. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..Our studies have identified secretory vesicle cathepsin L as a key processing enzyme for POMC, based on exciting new results from cathepsin L knockout mice showing ..
  32. Targeting a Unique Enzyme Mechanism in Non-Mammalian Isoprenoid Biosynthesis
    Jessica M Smith; Fiscal Year: 2013
    ..Biogenesis of isoprenoids is carried out via the methylerythritol phosphate (MEP) pathway in most human pathogens, including Mycobacterium tuberculosis and the malaria parasite Plasmodium ..
  33. Daniel E Gottschling; Fiscal Year: 2015
    ..cerevisiae. As part of this approach, we developed an inducible genetic system, the Mother Enrichment Program (MEP), which permits for the first time the facile isolation of replicatively aged S...
  34. Mortimer Poncz; Fiscal Year: 2015
    ..2) Arrest cells at the Meg-erythroid progenitor (MEP) stage to form self-replicating cells by knockdown of the transcription factor GATA1...
  35. Daniel E Gottschling; Fiscal Year: 2015
    ..We have recently overcome this limitation by development of the Mother Enrichment Program (MEP), and can now isolate and examine large populations of synchronously aged cells...
  36. MAP KINASE REGULATION OF SUBSTRATE PROTEINS
    Kerry Kornfeld; Fiscal Year: 2010
    ..Sumoylated LIN-1 represses transcription by interacting with MEP-1, DAS-1 and MAS-1, proteins involved in chromatin remodeling...
  37. Katayoon Dehesh; Fiscal Year: 2016
    ..methylerythritol cyclodiphosphate (MEcPP), an isoprenoid precursor produced by the methylerythritol phosphate (MEP) pathway...
  38. CUNEYT METIN ALPER; Fiscal Year: 2016
    ..established a unique, NIH funded, Clinical Research Center focused on the physiology of middle ear (ME) pressure (MEP) regulation...
  39. Fragment based inhibitor discovery of the MEP pathway in infectious organisms.
    BART LEE STAKER; Fiscal Year: 2011
    ..resonance (NMR) spectroscopy and X-ray crystallography to study enzymes from the methyl erythritol isoprenoid (MEP) biosynthetic pathway, which is essential in multiple pathogens and absent in humans...
  40. Syamal K Datta; Fiscal Year: 2014
    ..were c-Kit+CD41+CD151+ with properties of megakaryocyte (MkP) and/or bipotent megakaryocyte/erythroid progenitors (MEP) of bone marrow, hence the new APC are called M&M cells here...
  41. MYOSIN VI STEPS BACKWARDS: A COMPUTATIONAL STUDY TO ELUCIDATE THE MECHANISM
    VICTOR OVCHINNIKOV; Fiscal Year: 2010
    ..We will determine transition paths between the available crystal structures using Minimum Energy Path (MEP), Block Normal Mode (BNM) analysis, and steered/biased/targeted Molecular Dynamics...
  42. Membrane Permeable Diphosphate Analogs Targeting Pathogen Isoprenoid Biosynthesis
    CAREN L MEYERS; Fiscal Year: 2013
    ..cellular uptake and efficient intracellular activation of two polar inhibitor classes targeting the late stage MEP pathway enzyme, IspG, and farnesylpyrophosphate synthase (FPPS)...
  43. Dean C Crick; Fiscal Year: 2014
    This proposal is based on studies of the methylerythritol-4-phosphate (MEP) pathway that synthesizes the universal precursors of isoprenoid compounds, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), in which we have ..
  44. Structural Basis for Isoprenoid Biosynthesis
    JOSEPH NOEL; Fiscal Year: 2006
    ..pathway for IPP synthesis known as the 1-deoxy-D-xylulose 5-phosphate / 2-C-methyl-D-erythritol 4-phosphate (DXP/MEP) pathway...
  45. MicroRNAs regulating erythroid development
    Curt I Civin; Fiscal Year: 2010
    ..commitment, while (b) mir-16 may block development at the stage of a bipotent megakaryocyte-erythroid progenitor (MEP)...
  46. Methylerythritol Phosphate Pathway Inhibitors Targeting Gram-Negative Infections
    CHARLES TESTA; Fiscal Year: 2009
    ..underexploited pathway essential for the viability of all Gram-negative bacteria, the methylerythritol phosphate (MEP) pathway...
  47. Methylerythritol Phosphate Pathway-Specific Natural Products as Antibacterials
    CHARLES TESTA; Fiscal Year: 2009
    ..objective of this project is to identify a new class of antibiotics targeting the methylerythritol phosphate (MEP) pathway, a novel pathway essential for the viability of all Gram-negative and many Gram- positive bacteria...
  48. Multiplexed Encoded Particle PCR for Rapid Panel Diagnosis of Sexually-Transmitte
    DANIEL contact PREGIBON; Fiscal Year: 2010
    ..To this end, we will develop Multiplexed Encoded Particle PCR (mEP-PCR) assays to accurately and rapidly diagnose multiple sexually transmitted diseases (STDs) with a cost-effective, ..
  49. UCLA Clinical and Translational Science Institute
    Steven M Dubinett; Fiscal Year: 2011
    ..CTSA funding will accelerate our progress in achieving our transformative mission and allow the UCLA CTSI to make significant contributions to the goals of the national CTSA consortium. ..
  50. Steven M Dubinett; Fiscal Year: 2015
    ..CTSA funding will accelerate our progress in achieving our transformative mission and allow the UCLA CTSI to make significant contributions to the goals of the national CTSA consortium. ..
  51. Steven M Dubinett; Fiscal Year: 2015
    ..CTSA funding will accelerate our progress in achieving our transformative mission and allow the UCLA CTSI to make significant contributions to the goals of the national CTSA consortium. ..
  52. UCLA Clinical and Translational Science Institute
    Steven M Dubinett; Fiscal Year: 2011
    ..CTSA funding will accelerate our progress in achieving our transformative mission and allow the UCLA CTSI to make significant contributions to the goals of the national CTSA consortium. ..
  53. MALE INFERTILITY AND ITS BIOLOGICAL BASIS
    Barry Zirkin; Fiscal Year: 2002
    ..of stage-specific gene expression of analyses of Cyclic Protein-2, the pro-enzyme form of the cysteine protease Cathepsin L. It will be determined whether cis-acting elements in the CP-2/Cathepsin L gene and trans-acting factors in ..
  54. Anantha Shekhar; Fiscal Year: 2016
    ..Here we describe its innovative vision, its impact, and its success in creating public-private partnerships to benefit the health and economy of the state...
  55. Transcriptional regulation of proteinuria
    Sumant Chugh; Fiscal Year: 2007
    ..Specific factors that influence the binding of ZHX3 to the Cathepsin L and podocalyxin promoters will be studied by a combination of chromatin immunoprecipitation and site directed ..
  56. New Mexico Mental Health Mentorship/Education Program
    Howard Waitzkin; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The New Mexico Mentorship and Education Program (MEP) focuses on minority mental health issues in primary care settings, especially disparities in mental health outcomes...
  57. ETHANOL EFFECTS ON PROTEOLYTIC SYSTEMS IN THE LIVER
    TERRENCE DONOHUE; Fiscal Year: 2003
    ..In Specific Aim 1a, Lysosome biogenesis will be measured by examining the processing and compartmentalizatin of cathepsin L in hepatocytes isolated from control and ethanol-fed rats...
  58. Caren L Freel Meyers; Fiscal Year: 2016
    ..The essential methylerythritol phosphate (MEP) pathway for isoprenoid biosynthesis is widespread in human pathogens, including some of the most deadly infections ..
  59. Non-donor-Dependent Production of Wildtype and Modified Platelets
    Mortimer Poncz; Fiscal Year: 2009
    ..cells become OP9 independent/TPO-dependent and appear to have properties of a megakaryocyte-erythrocyte progenitor (MEP) cell...
  60. PDGF-RECEPTOR NEGATIVE CELLS
    Charles Scher; Fiscal Year: 1990
    ..We have recently utilized a cDNA probe of a PDGF-regulated lysosomal protein (termed MEP) to directly quantify a PDGF-modulated mRNA...
  61. Novel Seismic Solution for Prompt Location of Entrapped Miners
    Michele Williams; Fiscal Year: 2009
    ..techniques used are a combination of algorithms referred to collectively as the Multiple Event Processing (MEP) "pipeline," a key part of which are sophisticated algorithms that can detect weak signals characterized by a low ..
  62. Fatigue in MS: Effects of central conduction
    Andrea White; Fiscal Year: 2006
    ..central motor conduction during normal and thermally stressed conditions by recording motor evoked potential (MEP) amplitudes and latencies in abductor pollicus brevis (APB) muscle, 2) compare the extent of post-exercise ..
  63. DYNAMICS OF QUANTAL SUBUNIT POOLS OF TRANSMITTER RELEASE
    MAHLON KRIEBEL; Fiscal Year: 1990
    ..Release of AMECh will be identified by the shorter half decay time constant of the MEP currents recorded by a two electrode voltage clamp set-up...
  64. NOVEL SERPIN INHIBITOR OF ORAL SQUAMOUS CARCINOMA
    Robert Ord; Fiscal Year: 2007
    ..However, at low microenvironmental pH resulting from hypoxia or necrosis, col 18 is processed by cathepsin L, unless inhibited by extracellular CBP2/Hsp47, to ES...
  65. COMPUTATIONAL DESIGN OF HAPTENS TO DESTROY COCAINE
    GEORGE SHIELDS; Fiscal Year: 1999
    ..By comparing the molecular electrostatic potential (MEP) of the transition state with MEPs for different haptens, we will be able to identify the haptens that are closest ..