cathepsin B

Summary

Gene Symbol: cathepsin B
Description: cathepsin B
Alias: APPS, CPSB, cathepsin B, APP secretase, amyloid precursor protein secretase, cathepsin B1, cysteine protease
Species: human

Top Publications

  1. ncbi Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi
    J C Engel
    Department of Pathology, University of California, Veteran Administration Medical Center, San Francisco, USA
    J Cell Sci 113:1345-54. 2000
  2. doi Mycoplasma gallisepticum and Mycoplasma synoviae express a cysteine protease CysP, which can cleave chicken IgG into Fab and Fc
    Ivanka Cizelj
    Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI 1230 DomZale, Slovenia
    Microbiology 157:362-72. 2011
  3. ncbi Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism
    Tarek A Taha
    Division of General Internal Medicine, Ralph H Johnson Veterans Administration Hospital, Charleston, South Carolina 29401, USA
    J Biol Chem 280:17196-202. 2005
  4. ncbi Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells
    Jian Ping Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Mol Cell Biochem 292:189-95. 2006
  5. pmc Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
    Laszlo Herszenyi
    2nd Department of Medicine, Semmelweis University, Budapest Hungarian Academy of Science, Clinical Gastroenterology Research Unit, Budapest, Hungary
    BMC Cancer 8:194. 2008
  6. doi Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9
    Sasa Kenig
    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Vecna pot 111, Ljubljana, Slovenia
    Cancer Lett 289:53-61. 2010
  7. pmc Human tumour cathepsin B. Comparison with normal liver cathepsin B
    K Moin
    Department of Pharmacology Wayne State University, Detroit, MI 48201
    Biochem J 285:427-34. 1992
  8. ncbi Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells
    J Mai
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 275:12806-12. 2000
  9. ncbi Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1)
    M Riccio
    Institute of Cytomorphology N P, C N R c o Institute Codivilla Putti I O R, Via Di Barbiano 1 10, Bologna, 40136, Italy
    Exp Cell Res 262:84-94. 2001
  10. ncbi Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases
    S Gobeil
    Health and Environment Unit, Laval University Medical Research Center, CHUQ, and Faculty of Medicine, Laval University, Quebec, Canada
    Cell Death Differ 8:588-94. 2001

Research Grants

  1. Fayyaz S Sutterwala; Fiscal Year: 2014
  2. Stephen J Davies; Fiscal Year: 2014
  3. Controlled expression of a cystatin C-peptide as therapy for Alzheimer's disease
    PHYLLIS ANN SHAW; Fiscal Year: 2012
  4. Li Gan; Fiscal Year: 2014
  5. Development of protease inhibitor drugs to treat Alzheimer's disease
    GREGORY R HOOK; Fiscal Year: 2010
  6. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2000
  7. JEREMY KODANKO; Fiscal Year: 2016
  8. AIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2014
  9. Cathepsin L in the Biosynthesis of Enkephalins and beta-Endorphin Opioid Peptides
    Steven J Bark; Fiscal Year: 2012
  10. Dietmar W Siemann; Fiscal Year: 2016

Detail Information

Publications453 found, 100 shown here

  1. ncbi Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi
    J C Engel
    Department of Pathology, University of California, Veteran Administration Medical Center, San Francisco, USA
    J Cell Sci 113:1345-54. 2000
    A novel chemotherapy in development for Chagas' disease targets cruzain, the major cysteine protease of Trypanosoma cruzi...
  2. doi Mycoplasma gallisepticum and Mycoplasma synoviae express a cysteine protease CysP, which can cleave chicken IgG into Fab and Fc
    Ivanka Cizelj
    Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, SI 1230 DomZale, Slovenia
    Microbiology 157:362-72. 2011
    Major poultry pathogens M. gallisepticum and M. synoviae share a gene encoding a putative cysteine protease CysP similar to papain cysteine protease (C1A subfamily). Comparison of the cysP gene sequences of 18 M. synoviae and 10 M...
  3. ncbi Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism
    Tarek A Taha
    Division of General Internal Medicine, Ralph H Johnson Veterans Administration Hospital, Charleston, South Carolina 29401, USA
    J Biol Chem 280:17196-202. 2005
    ..In addition to caspase activation, TNF caused disruption of lysosomes with relocation of the cysteine protease cathepsin B into the cytosol...
  4. ncbi Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells
    Jian Ping Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Mol Cell Biochem 292:189-95. 2006
    Lysosomal cysteine protease cathepsin B has been reported to play an important role in apoptosis of many different cancer cells, but the regulation of cathepsin B in apoptosis is poorly understood...
  5. pmc Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
    Laszlo Herszenyi
    2nd Department of Medicine, Semmelweis University, Budapest Hungarian Academy of Science, Clinical Gastroenterology Research Unit, Budapest, Hungary
    BMC Cancer 8:194. 2008
    b>Cathepsin B and L (CATB, CATL), urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 play an important role in colorectal cancer invasion...
  6. doi Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9
    Sasa Kenig
    Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Vecna pot 111, Ljubljana, Slovenia
    Cancer Lett 289:53-61. 2010
    ..tumour cells significantly enhance the proliferation of co-cultured endothelial cells by a mechanism involving cathepsin B, but not cathepsin S...
  7. pmc Human tumour cathepsin B. Comparison with normal liver cathepsin B
    K Moin
    Department of Pharmacology Wayne State University, Detroit, MI 48201
    Biochem J 285:427-34. 1992
    b>Cathepsin B was purified from normal human liver and several human tumour tissues and partially characterized...
  8. ncbi Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells
    J Mai
    Department of Pharmacology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 275:12806-12. 2000
    To study potential roles of plasma membrane-associated extracellular cathepsin B in tumor cell invasion and metastasis, we used the yeast two-hybrid system to screen for proteins that interact with human procathepsin B...
  9. ncbi Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1)
    M Riccio
    Institute of Cytomorphology N P, C N R c o Institute Codivilla Putti I O R, Via Di Barbiano 1 10, Bologna, 40136, Italy
    Exp Cell Res 262:84-94. 2001
    ..Confocal microscopy analysis of the subcellular localization of cystatin B and cathepsin B shows that, in vivo, the two proteins are concentrated in different cell compartments...
  10. ncbi Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases
    S Gobeil
    Health and Environment Unit, Laval University Medical Research Center, CHUQ, and Faculty of Medicine, Laval University, Quebec, Canada
    Cell Death Differ 8:588-94. 2001
    ..These findings suggest that the necrotic cleavage of PARP-1 is caused in part or in totality by lysosomal proteases released during necrosis...
  11. ncbi The role of cathepsin B and cystatin C in the mechanisms of invasion by ovarian cancer
    Hiroshi Nishikawa
    Department of Obstetrics and Gynecology, Nagoya City University Medical School, Mizuho cho, Mizuho, Nagoya 467 8601, Japan
    Gynecol Oncol 92:881-6. 2004
    The aim of this study was to investigate the contribution of cathepsin B and cystatin C to the mechanisms of invasion by ovarian cancer.
  12. ncbi Simultaneous human papilloma virus type 16 E7 and cdk inhibitor p21 expression induces apoptosis and cathepsin B activation
    Dorte Wissing Kaznelson
    The DNA Tumour Virus Group, Institute of Molecular Pathology, The Protein Laboratory, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200, Copenhagen, Denmark
    Virology 320:301-12. 2004
    ..E7/p21-induced cell death is associated with the activation of a newly identified mediator of apoptosis, namely cathepsin B. Activation of the cellular caspases is undetectable in cells undergoing E7/p21-induced apoptosis...
  13. ncbi Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis
    Sajani S Lakka
    Program of Cancer Biology, Department of Biomedical and Therapeutic Sciences, University of Illinois, Peoria, IL 61656, USA
    Oncogene 23:4681-9. 2004
    ..Matrix metalloproteases (MMP)-9 and cathepsin B have been shown to participate in the processes of tumor growth, vascularization and invasion of gliomas...
  14. pmc Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection
    Kartik Chandran
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 308:1643-5. 2005
    ..Using selective protease inhibitors and protease-deficient cell lines, we identified an essential role for cathepsin B (CatB) and an accessory role for cathepsin L (CatL) in EboV GP-dependent entry...
  15. ncbi The cathepsin B death pathway contributes to TNF plus IFN-gamma-mediated human endothelial injury
    Jie Hui Li
    Department of Pathology and Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 175:1858-66. 2005
    ..that TNF in combination with LY294002, a PI3K inhibitor, activates caspase-independent cell death initiated by cathepsin B (Cat B) in HUVEC...
  16. ncbi Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro
    Ales Premzl
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
    J Cell Biochem 97:1230-40. 2006
    The lysosomal cysteine protease cathepsin B is implicated in degradation of extracellular matrix (ECM), a crucial step in a variety of physiological and pathological processes, including tumor dissemination and angiogenesis...
  17. pmc Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis
    S Mahurkar
    Genome Research Group, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India
    Gut 55:1270-5. 2006
    ..As cathepsin B (CTSB) is known to activate cationic trypsinogen, we attempted to understand the role of CTSB mutations in TCP...
  18. doi The expression of matrix metalloproteinase 9 and cathepsin B in gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival
    Jolanta Czyzewska
    Department of Clinical Laboratory Diagnostics, Medical University, Białystok, Poland
    Folia Histochem Cytobiol 46:57-64. 2008
    ..The purpose of this study was to investigate the relationship of the expression of MMP-9 and cathepsin B with tumor aggressiveness expressed by lymph node metastases and survival rates in gastric carcinoma patients...
  19. doi Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease
    Hsiu Ting Tsai
    School of Nursing, Chung Shan Medical University, Taichung, Taiwan
    Fertil Steril 91:549-55. 2009
    To detect the serum expression of cathepsin B and cystatin C and the ratio of cathepsin B to cystatin C in patients with pelvic inflammatory disease (PID) and speculate whether those are helpful indicators for the diagnosis of PID.
  20. pmc Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells
    Jie H Li
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    Am J Pathol 175:1124-35. 2009
    ..use of proteinase inhibitors, cell death changes from being principally caspase-dependent to being principally cathepsin B (Cat B)-dependent...
  21. pmc Cathepsin B is the driving force of esophageal cell invasion in a fibroblast-dependent manner
    Claudia D Andl
    Departments of Surgery and Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Neoplasia 12:485-98. 2010
    ..We also find that cathepsin B induction is necessary for fibroblast-mediated invasion...
  22. pmc Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation
    Sreelatha Gopinath
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
    PLoS ONE 5:e11668. 2010
    b>Cathepsin B and urokinase plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas...
  23. ncbi Identification of two new exons and multiple transcription start points in the 5'-untranslated region of the human cathepsin-B-encoding gene
    I M Berquin
    Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA
    Gene 159:143-9. 1995
    Transcripts for cysteine protease cathepsin B (CTSB) were found to be highly variable in the 5'-UTR (untranslated region)...
  24. ncbi Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status at the cellular level
    E Spiess
    Deutsches Krebsforschungszentrum, LVA Baden, Heidelberg, Germany
    J Histochem Cytochem 42:917-29. 1994
    We investigated the appearance and activity of the cysteine proteinase cathepsin B and its physiological inhibitors, stefins A and B, at the cellular level in human tumor cell lines HS-24, derived from a primary lung tumor (squamous cell)..
  25. ncbi Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells
    Lasse Foghsgaard
    Apoptosis Laboratory, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    J Biol Chem 277:39499-506. 2002
    ..Here, we show that cathepsin B-like proteases are required for the TNF-induced AA release in transformed cells...
  26. ncbi Molecular regulation of human cathepsin B: implication in pathologies
    Shiqing Yan
    Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Biol Chem 384:845-54. 2003
    Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells...
  27. ncbi Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion
    Marie Cecile Michallet
    Laboratoire d Immunopharmacologie, Institut National de la Santé et de la Recherche Médicale U503 and U404, Centre d Etudes et de Recherche en Virologie et Immunologie, Lyon, France
    Blood 102:3719-26. 2003
    ..The cysteine protease inhibitor E64d and cathepsin-B-specific inhibitors conferred significant protection, whereas apoptosis was ..
  28. doi Cathepsin B is a target of Hedgehog signaling in pancreatic cancer
    Jin Hyeok Hwang
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungon dong Chongno gu, Seoul 110 744, Republic of Korea
    Cancer Lett 273:266-72. 2009
    This study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer...
  29. ncbi In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. Subcellular distribution of the truncated enzyme in COS cells
    S Mehtani
    Department of Molecular and Cellular Biochemistry, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Biol Chem 273:13236-44. 1998
    Cathepsin B is a lysosomal cysteine protease whose increased expression is believed to be linked to the malignant progression of tumors...
  30. ncbi Exon skipping of cathepsin B: mitochondrial targeting of a lysosomal peptidase provokes cell death
    Kathrin Müntener
    Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Biol Chem 279:41012-7. 2004
    The alternatively spliced messenger RNA of the human cysteine peptidase cathepsin B missing exons 2 and 3 encodes a truncated form of the enzyme lacking the signal peptide and part of the inhibitory propeptide...
  31. doi IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts
    Tomoko Yamaguchi
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Cell Physiol 217:423-32. 2008
    ..In this study, we investigated the role of Cav-1 on (1) the productivity, and (2) the enzymatic activity of cathepsin B and L in human gingival fibroblasts (HGFs) treated with IL-6 in the presence of soluble form of IL-6 receptor (..
  32. ncbi [Cathepsin cysteine proteinases in the lung]
    F Buhling
    Institut fur Immunologie, Otto von Guericke Universitat Magdeburg
    Pneumologie 53:400-7. 1999
    ..Since the first reports showed an emphysema induction in rats after intratracheal application of the cysteine protease papain, a number of proteolytic enzymes involved in the remodeling of the extracellular matrix of the lung ..
  33. ncbi Cloning and expression of cathepsin L-like proteinases in the hepatopancreas of the shrimp Penaeus vannamei during the intermolt cycle
    C Le Boulay
    , Concarneau, France
    J Comp Physiol B 166:310-8. 1996
    b>Cysteine protease activities have been characterized with benzyloxycarbonyl-lysine p-nitrophenyl ester as a synthetic substrate and E64 as a specific inhibitor in the hepatopancreas of the shrimp Penaeus vannamei. An optimum pH of 5...
  34. ncbi Anti-cathepsin L monoclonal antibodies that distinguish cathepsin L from cathepsin V
    N Kopitar-Jerala
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Biol Chem 382:867-70. 2001
    Cathepsin L is a lysosomal cysteine protease involved in intracellular protein degradation. Recently, several new cysteine proteases have been identified...
  35. ncbi Fluorogenic peptide substrates for carboxydipeptidase activity of cathepsin B
    Krystyna Stachowiak
    Faculty of Chemistry, University of Gdansk, J Sobieskiego 18, 80 952 Gdansk, Poland
    Acta Biochim Pol 51:81-92. 2004
    Cathepsin B is a lysosomal cysteine protease exhibiting mainly dipeptidyl carboxypeptidase activity, which decreases dramatically above pH 5.5, when the enzyme starts acting as an endopeptidase...
  36. ncbi Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues
    Janko Kos
    Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, SI 1000 Ljubljana, Slovenia
    Exp Cell Res 306:103-13. 2005
    Cathepsin X, a recently discovered lysosomal cysteine protease, shares common structural features and activity properties with cysteine protease cathepsin B...
  37. doi Purification and characterization of cathepsin B-like cysteine protease from cotyledons of daikon radish, Raphanus sativus
    Akihiko Tsuji
    Department of Biological Science and Technology, University of Tokushima Graduate School, Japan
    FEBS J 275:5429-43. 2008
    Plant cathepsin B-like cysteine protease (CBCP) plays a role in disease resistance and in protein remobilization during germination...
  38. doi Cathepsin B differential expression and enzyme processing and activity during Fundulus heteroclitus embryogenesis
    Angèle Tingaud-Sequeira
    Laboratory of Institut de Recerca i Tecnologia Agroalimentàries IRTA Institut de Ciències del Mar, Consejo Superior de Investigaciones Cientificas CSIC, 08003 Barcelona, Spain
    Comp Biochem Physiol A Mol Integr Physiol 158:221-8. 2011
    The role of lysosomal proteases such as cathepsin B (Ctsb) and one of the paralogs of cathepsin L (Ctsla) during yolk metabolism in fish oocytes is well established...
  39. doi Single nucleotide polymorphisms in several porcine cathepsin genes are associated with growth, carcass, and production traits in Italian Large White pigs
    V Russo
    Dipartimento di Protezione e Valorizzazione Agroalimentare, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, 42100 Reggio Emilia, Italy
    J Anim Sci 86:3300-14. 2008
    ..including muscle postmortem cathepsin activity, several porcine genes encoding for lysosomal proteinases (cathepsin B, CTSB; cathepsin D, CTSD; cathepsin F, CTSF; cathepsin H, CTSH; cathepsin L, CTSL; and cathepsin Z, CTSZ) and ..
  40. ncbi Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors
    P M Selzer
    Department of Pathology, University of California, San Francisco 94143, USA
    Exp Parasitol 87:212-21. 1997
    ..cruzain, and human liver cathepsin B were used to build homology-based enzyme models of a cathepsin L-like cysteine protease (cpL) and a cathepsin B-like cysteine protease (cpB) from the protozoan parasite Leishmania major...
  41. ncbi Ratio of cathepsin B to stefin A identifies heterogeneity within Gleason histologic scores for human prostate cancer
    A A Sinha
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA
    Prostate 48:274-84. 2001
    Cathepsin B (CB), a lysosomal cysteine protease, is involved in degradation of extracellular matrix proteins and progression of tumor cells from one biological compartment to another in many solid organ cancers, including prostate cancer...
  42. ncbi Seven-up facilitates insect counter-defense by suppressing cathepsin B expression
    Ji Eun Ahn
    Department of Entomology, Texas A and M University, College Station, TX 77843, USA
    FEBS J 274:2800-14. 2007
    When challenged by the dietary soybean cysteine protease inhibitor scN, the cowpea bruchid (Callosobruchus maculatus) adapts to the inhibitory effects by readjusting the transcriptome of its digestive system, including the specific ..
  43. ncbi [Cysteine proteinase and neurodegeneration]
    J Jordan
    Instituto de Neurociencias, Facultad de Medicina, Universidad Miguel Hernandez, Alicante, Espana
    Rev Neurol 31:333-40. 2000
    ..This is a review of the part played by the cysteine proteases in different physiological and pathological processes...
  44. doi Functional expression of an insect cathepsin B-like counter-defence protein
    Y D Koo
    Department of Entomology, Texas A and M University, College Station, TX 77843, USA
    Insect Mol Biol 17:235-45. 2008
    ..Cowpea bruchids (Callosobruchus maculatus) strongly induce C. maculatus cathepsin B-like cysteine protease 1 (CmCatB1) transcripts when fed diet containing a soybean cysteine protease inhibitor soyacystatin N (scN)...
  45. pmc Coordination of hepatocyte nuclear factor 4 and seven-up controls insect counter-defense cathepsin B expression
    Ji Eun Ahn
    Department of Entomology, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 285:6573-84. 2010
    CmCatB, a cathepsin B-type cysteine protease, is insensitive to inhibition by the soybean cysteine protease inhibitor (scN)...
  46. doi Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide
    Fu Tie Zhang
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Fish Shellfish Immunol 25:542-9. 2008
    Cathepsin B is a lysosomal cysteine protease of the papain-like enzyme family with multiple biological functions...
  47. ncbi Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma
    Marco Niedergethmann
    Department of Surgery, University Hospital Mannheim, University of Heidelberg, Germany
    Pancreas 29:204-11. 2004
    The cysteine proteases cathepsin B (CTSB) and L (CTSL) have been implicated in tumor spread and metastatic formation. In pancreatic adenocarcinoma, the role of these proteases is not very well defined...
  48. doi Cathepsin B is not the processing enzyme for mouse prorenin
    Chantal Mercure
    Laboratory of Molecular Biochemistry of Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada
    Am J Physiol Regul Integr Comp Physiol 298:R1212-6. 2010
    ..several enzymes are capable of activating renin in vitro, the leading candidate for the PPE in the kidney is cathepsin B (CTSB) due to is colocalization with the renin precursor (prorenin) in juxtaglomerular cell granules and ..
  49. doi Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice
    L Sevenich
    Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Freiburg, Germany
    Oncogene 30:54-64. 2011
    Elevated expression of the cysteine protease cathepsin B (CTSB) has been correlated with a poor prognosis for cancer patients...
  50. ncbi The baculovirus cysteine protease has a cathepsin B-like S2-subsite specificity
    D Bromme
    Khepri Pharmaceuticals, Inc, South San Francisco, CA 94080, USA
    Biol Chem Hoppe Seyler 376:611-5. 1995
    Autographa californica nuclear polyhedrosis virus (AcNPV) encodes a functional cysteine protease of the papain family which is expressed after infection in Spodoptera fruglperda Sf9 cells...
  51. ncbi Inhibition of cathepsin K by nitric oxide donors: evidence for the formation of mixed disulfides and a sulfenic acid
    M D Percival
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
    Biochemistry 38:13574-83. 1999
    The cysteine protease cathepsin K is believed to play a key role in bone resorption as it has collagenolytic activity and is expressed predominantly and in high levels in bone resorbing osteoclast cells...
  52. pmc Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini
    Porntip Pinlaor
    Department of Pathology, Khon Kaen University, Khon Kaen, Thailand
    PLoS Negl Trop Dis 3:e398. 2009
    ..viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to the pathologies associated with hepatobiliary abnormalities...
  53. ncbi Characterisation of Tc-cpl-1, a cathepsin L-like cysteine protease from Toxocara canis infective larvae
    A Loukas
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Mol Biochem Parasitol 92:275-89. 1998
    Cysteine proteases play vital biological roles in both intracellular and extracellular environments. A cysteine protease migrating at 30 kDa was identified in somatic extracts of Toxocara canis larvae (TEX), by its binding to the ..
  54. ncbi 3-hydroxy-3-methylglutaryl coenzyme A reductase is sterol-dependently cleaved by cathepsin L-type cysteine protease in the isolated endoplasmic reticulum
    T Moriyama
    Research Institute for Food Science, Kyoto University, Gokasho, Japan
    Arch Biochem Biophys 386:205-12. 2001
    ..degraded in ER membranes prepared from sterol pretreated cells and that such degradation is catalyzed by a cysteine protease within the reductase membrane domain...
  55. ncbi Purification and characterization of cathepsin J from rat liver
    T Nikawa
    Division of Enzyme Chemistry, University of Tokushima, Japan
    Eur J Biochem 204:381-93. 1992
    ..Cathepsin J was found to be a lysosomal high-molecular-mass cysteine protease of about 160 kDa consisted of two different subunits...
  56. ncbi Cloning and expression of a rat placental cDNA encoding a novel cathepsin L-related protein
    P R Conliffe
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville 32610, USA
    Mol Reprod Dev 40:146-56. 1995
    Cathepsin L is a major lysosomal cysteine protease produced by mouse placenta and fibroblasts. This study characterizes a novel cathepsin L-related mRNA expressed in rat placenta...
  57. ncbi Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L
    L Goretzki
    Frauenklinik der Technischen Universitat Munchen, Klinikum rechts der Isar, Germany
    FEBS Lett 297:112-8. 1992
    Increased levels of both the cysteine protease, cathepsin L, and the serine protease, uPA (urokinase-type plasminogen activator), are present in solid tumors and are correlated with malignancy...
  58. ncbi Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization
    D Bromme
    Department of Human Genetics, Mount Sinai School of Medicine, CUNY, New York 10029, USA
    Biochemistry 38:2377-85. 1999
    Cathepsin V, a thymus and testis-specific human cysteine protease, was expressed in Pichia pastoris, and its physicokinetic properties were determined...
  59. ncbi Regulation of collagenolytic cysteine protease synthesis by estrogen in osteoclasts
    N Furuyama
    Discovery Research Laboratory, Takeda Chemical Industries, Ltd, 17 85, Juso honmachi 2 chome, Yodogawa ku, 532 8686, Osaka, Japan
    Steroids 65:371-8. 2000
    In ovariectomized (Ovx) mice, collagenolytic cysteine protease (CCP) activity in calvaria significantly increased 7 days after ovariectomy and was about 50% of that observed in sham-operated (Sham) mice 3 weeks later...
  60. ncbi Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum
    T Wex
    Department of Human Genetics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 167:2172-8. 2001
    Human cathepsin W (also called lymphopain) is a recently described papain-like cysteine protease of unknown function whose gene expression was found to be restricted to cytotoxic cells...
  61. ncbi The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles
    Sascha Hagemann
    Institut für Molekulare Medizin und Zellforschung, Universitat Freiburg, Freiburg, Germany
    Eur J Cell Biol 83:775-80. 2004
    Mice lacking the ubiquitously expressed lysosomal cysteine protease cathepsin L, show a complex skin phenotype consisting of periodic hair loss and epidermal hyperplasia with hyperproliferation of basal epidermal keratinocytes, ..
  62. ncbi Cysteine protease inhibitors as chemotherapy for parasitic infections
    J H McKerrow
    Department of Pathology, VA Medical Center, University of California, San Francisco 94121, USA
    Bioorg Med Chem 7:639-44. 1999
    ..The treatment of experimental models of parasitic diseases with cysteine protease inhibitors has provided an important 'proof of concept' for the use of cysteine protease inhibitors in vivo...
  63. ncbi Cloning, characterization and primary function study of a novel gene, Cymg1, related to family 2 cystatins
    Yang Xiang
    Human Reproductive and Stem Cell Engineering Institute, Central South University, Changsha 410078, China
    Acta Biochim Biophys Sin (Shanghai) 37:11-8. 2005
    ..The protein has a cysteine protease inhibitor domain that is related to the family 2 cystatins but lacks critical consensus sites important for ..
  64. ncbi Basis for low affinity binding of a lysosomal cysteine protease to the cation-independent mannose 6-phosphate receptor
    J M Dong
    Department of Physiology, School of Medicine and Veterinary Medicine, Tufts University, Boston, Massachusetts 02111
    J Biol Chem 265:4210-7. 1990
    In cultured mouse fibroblasts, secretion of the lysosomal cysteine protease, MEP (major excreted protein) is regulated by growth factors and viral transformation...
  65. ncbi Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi
    J C Engel
    Department of Pathology, University of California, San Francisco, California 94143, USA
    J Cell Sci 111:597-606. 1998
    Cruzain, the major cysteine protease of the protozoan parasite Trypanosoma cruzi, is a target of rational drug design for chemotherapy of Chagas' disease...
  66. doi Cystatins--Extra- and intracellular cysteine protease inhibitors: High-level secretion and uptake of cystatin C in human neuroblastoma cells
    Hanna Wallin
    Department of Laboratory Medicine, Division of Clinical Chemistry and Pharmacology, Lund University, Skane University Hospital, SE 221 85 Lund, Sweden
    Biochimie 92:1625-34. 2010
    ..fish, insects, plants, fungi and protozoa and constitute a large protein family, with most members sharing a cysteine protease inhibitory function...
  67. ncbi A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin
    V Kapur
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030
    Microb Pathog 15:327-46. 1993
    Streptococcus pyogenes secretes an extracellular cysteine protease that cleaves human interleukin 1 beta precursor to form biologically active IL-1 beta, a major cytokine mediating inflammation and shock...
  68. ncbi Up-regulation of cystatin C expression in the murine hippocampus following perforant path transections
    G X Ying
    Key Laboratory of Neurobiology, Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China
    Neuroscience 112:289-98. 2002
    Cystatins are endogenous cysteine protease inhibitors that modulate the turnover of intracellular and extracellular proteins...
  69. ncbi Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system
    Li Qun Jiang
    Division of Biochemistry, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China
    Hypertens Res 25:647-52. 2002
    Calpain, a cytosolic cysteine protease, requires calcium ions for activity...
  70. doi Expression of sweet potato cysteine protease SPCP2 altered developmental characteristics and stress responses in transgenic Arabidopsis plants
    Hsien Jung Chen
    Department of Biological Sciences, National Sun Yat Sen University, 804 Kaohsiung, Taiwan
    J Plant Physiol 167:838-47. 2010
    In this report a full-length cDNA, SPCP2, which encoded a putative papain-like cysteine protease was isolated from senescent leaves of sweet potato (Ipomoea batatas)...
  71. pmc Alterations in the testis and epididymis associated with loss of function of the cystatin-related epididymal spermatogenic (CRES) protein
    Adam D Parent
    Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
    J Androl 32:444-63. 2011
    ..epididymal spermatogenic protein (CRES) or cystatin 8 (Cst8 gene) is a member of the cystatin superfamily of cysteine protease inhibitors...
  72. doi Identification and functional characterization of CsStefin-1, a cysteine protease inhibitor of Clonorchis sinensis
    Jung Mi Kang
    Department of Parasitology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Gyeongsangnamdo, South Korea
    Mol Biochem Parasitol 177:126-34. 2011
    ..In this study, we identified and characterized a novel cysteine protease inhibitor of C. sinensis, CsStefin-1, as a modulator of CsCFs...
  73. ncbi Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine
    J Sivaraman
    Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Quebec, H4P 2R2, Canada
    J Mol Biol 295:939-51. 2000
    ..This insertion, thought to be an equivalent of cathepsin B occluding loop, is located on the side of the protein, distant from the substrate binding site.
  74. ncbi Molecular cloning, expression and modelling of cat allergen, cystatin (Fel d 3), a cysteine protease inhibitor
    K Ichikawa
    Asthma and Allergic Diseases Center, University of Virginia, Charlottesville, USA
    Clin Exp Allergy 31:1279-86. 2001
    ..IgE antibodies to Fel d 1 and albumin do not fully account for IgE responses to cat and there is good immunochemical evidence that cats produce other allergens...
  75. doi Biochemical and molecular characterization of senescence-related cysteine protease-cystatin complex from spinach leaf
    Takayuki Tajima
    Department of Biological Science, Faculty of Science, Shizuoka University, Shizuoka 422 8529, Japan
    Physiol Plant 141:97-116. 2011
    ..CP2 was a monomer complex (SoCP-CPI) (51 kDa) composed of a 41-kDa core protein, SoCP (Spinacia oleracea cysteine protease), and 14-kDa cystatin, a cysteine protease inhibitor (CPI), while CP3 was a trimer complex (SoCP-CPI)(3) (..
  76. ncbi The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development
    Sarwar Hashmi
    Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    J Biol Chem 279:6035-45. 2004
    We have analyzed the expression and function of Cecpz-1, a Caenorhabditis elegans cathepsin Z-like cysteine protease gene, during development of the worm...
  77. doi Zingipain, A cysteine protease from Zingiber ottensii Valeton rhizomes with antiproliferative activities against fungi and human malignant cell lines
    Aphichart Karnchanatat
    Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, Bangkok, Thailand
    Prep Biochem Biotechnol 41:138-53. 2011
    The objective of this study was to investigate the activity of a protein identified as cysteine protease, purified from Zingiber ottensii Valeton rhizomes, in terms of antiproliferation against fungi, bacteria, and human malignant cell ..
  78. ncbi Cloning and expression of cystatin, a potent cysteine protease inhibitor from the gut of Haemonchus contortus
    G F Newlands
    Moredun Research Institute, International Research Centre, Bush Loan, Penicuik, Scotland
    Parasitology 122:371-8. 2001
    A cDNA encoding a cysteine protease inhibitor (cystatin) was identified by immunoscreening a Haemonchus contortus cDNA library with antisera from lambs vaccinated with a protective membrane protein complex (H-gal-GP) derived from the gut ..
  79. ncbi Cloning of a cysteine protease required for the molting of Onchocerca volvulus third stage larvae
    S Lustigman
    Laboratory of Virology and Parasitology, The Lindsley F Kimball Research Institute, New York Blood Center, New York, New York 10021, USA
    J Biol Chem 271:30181-9. 1996
    We have investigated the involvement of a cysteine protease in the development of Onchocerca volvulus fourth stage larvae (L4) by testing the effect of cysteine protease inhibitors on the survival of third stage larvae (L3), and the ..
  80. ncbi Functional aspects of the human salivary cystatins in the oral environment
    A Baron
    Department of Restorative Dentistry, University of California, San Francisco, CA 94143, USA
    Oral Dis 5:234-40. 1999
    The aim of this study was to investigate the cysteine protease inhibitory properties of the human salivary cystatins S, SA and SN in order to identify potential in vivo target cysteine proteases which may include those involved in ..
  81. pmc Immunomodulatory peptide from cystatin, a natural cysteine protease inhibitor, against leishmaniasis as a model macrophage disease
    Snigdha Mukherjee
    Molecular Cell Biology Laboratory, Indian Institute of Chemical Biology, Calcutta, India
    Antimicrob Agents Chemother 51:1700-7. 2007
    Cystatin, a natural cysteine protease inhibitor, has strong antileishmanial activity, which is due to its potential to induce nitric oxide (NO) generation from macrophages...
  82. doi Purification and properties of cysteine protease from rhizomes of Curcuma longa (Linn.)
    Radhakrishnan Nagarathnam
    Centre for Advanced Studies in Botany, Guindy Campus, University of Madras, Chennai 600025, Tamil Nadu, India
    J Sci Food Agric 90:97-105. 2010
    ..Curcumin from turmeric rhizomes has been used for healing many ailments, including cancer. The purpose of this study was to purify turmeric protease and to research their biochemical characteristics [corrected]...
  83. ncbi Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease
    Anna Ljunggren
    Department of Laboratory Medicine, Division of Clinical Chemistry and Pharmacology, Lund University, University Hospital, SE 221 85 Lund, Sweden
    J Mol Biol 371:137-53. 2007
    ..This small protein belongs to a recently defined family of cysteine protease inhibitors...
  84. pmc Identification of the major cysteine protease of Giardia and its role in encystation
    Kelly N DuBois
    Department of Pathology, the Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, CA 94158, USA
    J Biol Chem 283:18024-31. 2008
    ..Using quantitative real-time PCR, the expression of twenty-seven clan CA cysteine protease genes in the Giardia genome was measured during both vegetative growth and encystation...
  85. pmc Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells
    Joseph W Golden
    Department of Microbiology, University of Minnesota, Mayo Mail Code 196, 420 Delaware St S E, Minneapolis, Minnesota 55455, USA
    Virol J 2:48. 2005
    ..Because reovirus replication in rodent lungs causes ARDS-like symptoms and induces an infiltration of neutrophils, we investigated the capacity of NE to promote reovirus virion uncoating...
  86. ncbi Purification of a cysteine protease inhibitor from larval hemolymph of the tobacco hornworm (Manduca sexta) and functional expression of the recombinant protein
    Takayuki Miyaji
    Laboratory of Food Molecular Functionality, College of Agriculture, Ibaraki University, 3 21 1 Chuo, Ami Machi, Inashiki Gun, Ibaraki 300 0393, Japan
    Insect Biochem Mol Biol 37:960-8. 2007
    A cysteine protease inhibitor (CPI) with an apparent molecular mass of 11...
  87. ncbi Hemostasis of tiger prawn Penaeus monodon affected by Vibrio harveyi, extracellular products, and a toxic cysteine protease
    K K Lee
    Department of Aquaculture, National Taiwan Ocean University, Keelung, Taiwan
    Blood Cells Mol Dis 25:180-92. 1999
    The effects of bacterial cells, extracellular products (ECP) and a purified cysteine protease of Vibrio harveyi on hemostasis and plasma components of tiger prawn (Penaeus monodon) were studied...
  88. ncbi Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles
    Vivian Y H Hook
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurochem 81:237-56. 2002
    ..Evidence for cysteine protease activity was shown by E64c inhibition of Z-Val-Lys-Met-MCA-cleaving activity, and E64c inhibition of Abeta(1-..
  89. pmc Differences in cysteine protease activity in Schistosoma mansoni-resistant and -susceptible Biomphalaria glabrata and characterization of the hepatopancreas cathepsin B Full-length cDNA
    Jocelyn Myers
    Department of Biology, Howard University, NW, Washington, DC 20059, USA
    J Parasitol 94:659-68. 2008
    ..Lytic activity coincided with a high-molecular-weight smear (220 to 66 kDa) that was abrogated by the cysteine protease inhibitor trans-epoxysuccinyl-l-leucylamido-(4-guanidino)butane. Quantitative flourimetric assays showed 3...
  90. doi Echinococcus multilocularis metacestode metabolites contain a cysteine protease that digests eotaxin, a CC pro-inflammatory chemokine
    N Mejri
    Institute of Parasitology, University of Berne, 3012 Bern, Switzerland
    Parasitol Res 105:1253-60. 2009
    ..Using appropriate inhibitors, the respective protease was identified as a cysteine protease, which required the presence of Ca(++) as co-enzyme...
  91. doi 'Pergularain e I'--a plant cysteine protease with thrombin-like activity from Pergularia extensa latex
    Holenarasipura V Shivaprasad
    Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore 570 006, India
    Thromb Res 125:e100-5. 2010
    Pergularain e I, a cysteine protease with thrombin-like activity, was purified by ion exchange chromatography from the latex of Pergularia extensa...
  92. pmc A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection
    Patricia S Doyle
    Department of Pathology, University of California San Francisco, CA 94121, USA
    Antimicrob Agents Chemother 51:3932-9. 2007
    ..A promising group of new drug leads for Chagas' disease is cysteine protease inhibitors targeting cruzain, the major protease of T. cruzi...
  93. ncbi Calpain localization changes in coordination with actin-related cytoskeletal changes during early embryonic development of Drosophila
    Y Emori
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
    J Biol Chem 269:25137-42. 1994
    ..highly homologous to those of mammalian calpains and exhibits a distinct domain structure consisting of cysteine protease and calcium-binding domains...
  94. ncbi Cathepsin B, a cysteine protease implicated in metastatic progression, is also expressed during regression of the rat prostate and mammary glands
    R S Guenette
    W Alton Jones Cell Science Center, Lake Placid, NY 12946
    Eur J Biochem 226:311-21. 1994
    ..In this investigation, we have characterized one of these genes, RSG-2, that is homologous to cathepsin B, a thiol protease that has been previously identified as one of the extracellular proteases which is activated ..
  95. ncbi Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
    M Enari
    Osaka Bioscience Institute, Osaka, Japan
    Nature 380:723-6. 1996
    ..The interleukin-1Beta-converting enzyme (ICE) is a cysteine protease that is involved in apoptosis induced by various stimuli, including Fas-mediated apoptosis...
  96. ncbi Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells
    N Koshikawa
    Division of Cell Biology, Yokohama City University
    J Biochem 119:334-9. 1996
    ..demonstrated that the purified inhibitors were identical to the secreted forms of amyloid protein precursors (APPs), tissue factor pathway inhibitor (TFPI), placental protein 5 (PP5)/TFPI-2, and secretory leukocyte proteinase ..
  97. ncbi Molecular characterization of group A streptococcal (GAS) oligopeptide permease (opp) and its effect on cysteine protease production
    A Podbielski
    Institute of Medical Microbiology, Hospital of the Technical University Klinikum RWTH, Aachen, Germany
    Mol Microbiol 21:1087-99. 1996
    ..and attachment to eukaryotic cells were unaffected, the oppD/F mutants showed reduced production of the cysteine protease, SpeB, and a change in the pattern of secreted proteins...
  98. ncbi Purification and characterization of cathepsin L from hepatopancreas of carp Cyprinus carpio
    F Aranishi
    National Research Institute of Fisheries Science, Yokohama, Japan
    Comp Biochem Physiol B Biochem Mol Biol 118:531-7. 1997
    ..5-6.0 and 50 degrees C and the remarkable stability at pH 5.0-6.5 and below 40 degrees C. All tested cysteine protease inhibitors and TLCK and chymostatin markedly inhibited its activity, whereas the other serine protease ..
  99. ncbi Molecular cloning and biochemical characterisation of proteases from Staphylococcus epidermidis
    G Dubin
    Institute of Molecular Biology, Jagiellonian University, Krakow, Poland
    Biol Chem 382:1575-82. 2001
    ..The first enzyme shows an extended sequence similarity to Staphylococcus aureus cysteine protease (staphopain) and the second one resembles the serine protease produced by that species...
  100. ncbi Possible identity of IL-8 converting enzyme in human fibroblasts as a cysteine protease
    Kensaku Ohashi
    Pharmaceutical Research Laboratories, Toray Industries, Inc, 1111 Tebiro, Kanagawa Kamakura 248 8555, Japan
    Int Immunopharmacol 3:609-14. 2003
    ..The converting activity, which was temperature-dependent and optimal at pH 6, was completely inhibited by cysteine protease inhibitors, antipain dihydrochloride and E-64, but not by other types of protease inhibitors...
  101. pmc Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes
    Melody N Neely
    Department of Immunology and Microbiology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
    J Bacteriol 185:5166-74. 2003
    ..the Rgg family member RopB is required for transcription of the gene that encodes the secreted SpeB cysteine protease. Expression of the protease follows distinct kinetics that involves control of transcription in response to ..

Research Grants68

  1. Fayyaz S Sutterwala; Fiscal Year: 2014
    ..The activation of the Nlrp3 inflammasome ultimately results in the activation of the cysteine protease caspase-1 and its processing and secretion of proinflammatory cytokines. C...
  2. Stephen J Davies; Fiscal Year: 2014
    ..This hypothesis is supported by the observation that cysteine protease activity is also associated with many Th2-inducing allergens, and that cysteine proteases derived from non-..
  3. Controlled expression of a cystatin C-peptide as therapy for Alzheimer's disease
    PHYLLIS ANN SHAW; Fiscal Year: 2012
    ..Cathepsin B, a cysteine protease present in the brain, can degrade A? peptides, however, blocking its enzymatic activity in vivo with its ..
  4. Li Gan; Fiscal Year: 2014
    ..We discovered that cathepsin B (CatB), a cysteine protease, degrades Abeta in vitro and in vivo...
  5. Development of protease inhibitor drugs to treat Alzheimer's disease
    GREGORY R HOOK; Fiscal Year: 2010
    ..CA074Me and loxistatin (also known as E64d or EST) are cysteine protease inhibitors and the cysteine protease, cathepsin B, is a candidate 2-secretase in the regulated secretory ..
  6. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2000
    ..In our previous studies we identified a cysteine protease inhibitor, onchocystatin, and a cathepsin Z-like cysteine protease and proposed that they are essential for ..
  7. JEREMY KODANKO; Fiscal Year: 2016
    ..This proposal aims to develop and validate light-activated cysteine protease inhibitors as basic research tools, and potential therapeutics in metastatic bone disease...
  8. AIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2014
    ..The cysteine protease, cathepsin K (CTSK), is a major collagenase involved in osteoclastic bone resorption...
  9. Cathepsin L in the Biosynthesis of Enkephalins and beta-Endorphin Opioid Peptides
    Steven J Bark; Fiscal Year: 2012
    ..These new findings indicate a distinct cysteine protease pathway, in addition to the well known subtilisin-like Prohormone Convertases 1 and 2 for production of ..
  10. Dietmar W Siemann; Fiscal Year: 2016
    ..The current proposal is focused on therapeutically targeting a key player in the metastatic cascade;the cysteine protease cathepsin L (CTSL)...
  11. Ethan A Lerner; Fiscal Year: 2014
    ..We have determined that the active compound in cowhage is mucunain, a cysteine protease. We have also determined that mucunain is a ligand for human protease-activated receptors 2 and 4...
  12. PROTEOMICS OF REGULATED EXOCYTOSIS IN OSTEOCLASTS
    F Ross; Fiscal Year: 2007
    ..first mobilizes the mineral phase of bone followed by organic matrix digestion via the lysosomal cysteine protease, Cathepsin K...
  13. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2007
    The endosomal cysteine protease, cathepsin S, has a key role in MHC class II (MHCII)-dependent immunity through its role in degradation of the MHCII-associated chaperone, the invariant chain (Ii)...
  14. Prodrugs to treat Alzheimer's disease
    GREGORY R HOOK; Fiscal Year: 2010
    ..structurally very similar, E64c inhibits cysteine proteases generally whereas CA074 selectively inhibits the cysteine protease, cathepsin B...
  15. CLIFFORD RUSSELL GREYSON; Fiscal Year: 2016
    ..that RV contractile failure from acute pulmonary hypertension is associated with activation of the cysteine protease calpain in the RV, and that right heart failure in this setting may be attenuated by a calpain inhibitor...
  16. Characterization of a novel protein required for glomerular podocyte function
    LORI L O'BRIEN; Fiscal Year: 2012
    ..It is a downstream target of Wilms'tumor suppressor-1 (WT1) and binds capnsi, the small subunit of the cysteine protease calpain...
  17. Wei Xing Zong; Fiscal Year: 2016
    ..We also reported that an endogenous serine/cysteine protease inhibitor SerpinB3 (also termed squamous cell carcinoma antigen 1, SCCA1) may function as a molecular ..
  18. K777 for treatment of Chagas Disease: IND-enabling Studies and IND Submission
    Robert Don; Fiscal Year: 2012
    ..Thus, there is a desperate need for new drugs to treat this debilitating disease. K777 is a vinyl sulfone cysteine protease inhibitor which irreversibly inhibits cruzain, a key protease required for viability of Trypanosoma cruzi, ..
  19. Identifying Calpain-10 Substrates from Human Proteome
    Rihe Liu; Fiscal Year: 2005
    ..genes implicate that genetic variation in the CAPN10 gene, which encodes ubiquitously expressed cysteine protease calpain-10, is associated with increased risk of type 2 diabetes in a population of Mexican Americans who ..
  20. A New Class of Serine and Cysteine Protease Inhibitors
    CHRISTOPHER SETO; Fiscal Year: 2006
    ..Finally, the optimized inhibitors will be examined for their ability to inhibit dephosphorylation of the insulin receptor that is catalyzed by PTP1B. ..
  21. Fic-mediated Adenylylation
    CAROLYN ANN WORBY; Fiscal Year: 2013
    ..We previously demonstrated that Yersinia YopT functions as a cysteine protease that cleaves and inactivates Rho GTPases...
  22. Molecular mechanisms of pathogen recognition by the Nod-like receptor NLRC4
    Fayyaz S Sutterwala; Fiscal Year: 2012
    ..The activation of the NLRC4 inflammasome ultimately results in the activation of the cysteine protease caspase-1 and its processing and secretion of proinflammatory cytokines. P...
  23. Gabriel Nunez; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Caspase-1, a cysteine protease, is critical for the production of mature IL-1b and IL-18, two pro-inflammatory cytokines that play an important role in host defense, sepsis, and the pathogenesis of ..
  24. Xiang Jin Meng; Fiscal Year: 2016
    ..The findings that the papain-like cysteine protease (PCP) domain in HEV ORF1 has deubiquitinating activity and carries out deISGylation of ISG15-conjugated ..
  25. Richard C Condit; Fiscal Year: 2014
    ..The project will focus on a subset of nine core proteins that break down into four categories: 1) a cysteine protease required for cleavage of the major structural virion proteins (I7L), 2) four putative core wall proteins (A3,..
  26. Role of HCV p7 and NS2 in infectious virus production
    Charles M Rice; Fiscal Year: 2012
    ..the post-cleavage form of the NS2 autoprotease (revealing a domain exchanged homodimer with two composite cysteine protease active sites) to include full-length NS2...
  27. Vishwa Deep Dixit; Fiscal Year: 2014
    ..The cysteine protease, caspase-1, is required for the secretion of IL-1[unreadable] and IL-18 from myeloid-lineage cells...
  28. Richard B Cooley; Fiscal Year: 2014
    ..LapD is a transmembrane receptor that regulates the activity of the periplasmic cysteine protease LapG by sensing cytoplasmic c-di-GMP levels through a still poorly understood mechanism...
  29. Imaging of Cardiac Transplant Rejection
    Matthias Nahrendorf; Fiscal Year: 2013
    ..we will validate a) nanoparticles as reporters of phagocytic activity, b) optical prodrugs as sensors of cysteine protease activity, and c) myeloperoxidase-targeted magnetic resonance imaging agents...
  30. Gabriel Nunez; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Caspase-1, a cysteine protease, is critical for the processing and secretion of IL-1( and IL-18, two pro- inflammatory cytokines that play an important role in host defense, sepsis, and the ..
  31. Functional characterization of Rho inactivation by Vibro cholerae RTX toxin
    BRETT L GEISSLER; Fiscal Year: 2010
    ..for cross-linking actin, the Rho-inactivation domain (RID) that is sufficient for inactivating Rho, and the cysteine protease domain (CPD) whose function is unknown...
  32. Genetic and Biochemical Study of V. cholerae RTX Toxin
    Karla J F Satchell; Fiscal Year: 2012
    ..Finally, this toxin has a cysteine protease domain with autoprocessing activity that may also have cellular targets resulting in cytotoxicity...
  33. Repression of inflammasome by Francisella tularensis
    Meenakshi Malik; Fiscal Year: 2013
    ..The inflammasome complex activates cysteine protease caspase1 which in-turn activates pro-forms of pro-inflammatory cytokines IL-1[unreadable] and IL-18 to their ..
  34. Chemically Interrogating Clostridium difficile Glucosylating Toxin Activation
    Aimee Shen; Fiscal Year: 2010
    ..work thus far, I have discovered a unique mechanism of protease activation and delineated a role for a cysteine protease domain (CPD) in autoprocessing a newly recognized family of bacterial toxins...
  35. Timothy Tellinghuisen; Fiscal Year: 2014
    ..NS2 is a papain-like cysteine protease that catalyzes the auto-catalytic cleavage of the NS2/NS3 junction in the viral polyprotein, and this ..
  36. Mechanism and Inhibition of Arginine Deiminase
    Hua Guo; Fiscal Year: 2010
    ..Superficially similar to cysteine protease, arginine deiminase has a conserved Cys-His-Glu triad and uses Cys in covalent catalysis...
  37. Cytomegalovirus Deubiquitinase pUL48: Identifying Substrate and Inhibitors
    D WADE GIBSON; Fiscal Year: 2010
    Herpes-group viruses have recently been discovered to encode a ubiquitin-specific cysteine protease, whose biological function is unknown...
  38. Caroline A Genco; Fiscal Year: 2016
    ..We demonstrate that the lysine-specific bacterial cysteine protease of P...
  39. Dysregulation of ubiquitination in MALT lymphomas
    Xiaolu Yang; Fiscal Year: 2010
    ..of Bcl10, an adapter protein critical for antigen receptor signaling to NF-kB, and MALT1, a putative cysteine protease, respectively...
  40. Al-2-Dependent Quorum Sensing in the Gram-Positive Bacterium Streptococcus pyogen
    Michael J Federle; Fiscal Year: 2010
    ..AI-2 controls production of SLS (hemolysin) and SpeB (cysteine protease) which are required for S. pyogenes virulence...
  41. Neural Mechanisms of Itch
    ROBERT H LA MOTTE; Fiscal Year: 2013
    ..to histamine, and others to the spicules of cowhage that evoked a histamine independent itch via a novel cysteine protease that we identified...
  42. Chemically Interrogating Clostridium difficile Glucosylating Toxin Activation
    Aimee Shen; Fiscal Year: 2013
    ..work thus far, I have discovered a unique mechanism of protease activation and delineated a role for a cysteine protease domain (CPD) in autoprocessing a newly recognized family of bacterial toxins...
  43. James J Havranek; Fiscal Year: 2016
    ..Visualization will be performed with single molecule fluorescence microscopy. A cysteine protease will be engineered to remove terminal amino acids to regenerate a new peptide N-terminus for subsequent ..
  44. Michael J Federle; Fiscal Year: 2015
    ..An inverse relationship exists between expression levels of the secreted cysteine protease, SpeB, and severity of disease [1-3]...
  45. Role of Red Cell Membrane in Malaria Parasite Release
    Manjit Hanspal; Fiscal Year: 2006
    ..Recently, we identified a novel P. falciparum cysteine protease named falcipain-2 (FP-2) that cleaves host erythrocyte membrane ankyrin, protein 4...
  46. EOSINOPHIL APOPTOSIS IN ASTHMA
    Gerald Litwack; Fiscal Year: 2001
    ..The Ced- 3/ICE cysteine protease gene family are important pro-apoptotic mediators, while Bcl-2 and related proteins provide important ..
  47. Promiscuous and Specific Inhibitors of Cruzain
    Brian Shoichet; Fiscal Year: 2007
    ..To determine the ratio of promiscuous and covalent inhibitors in an HTS screen of the cysteine protease cruzain...
  48. Role of cysteine proteases in malaria transmission
    KIM WILLIAMSON; Fiscal Year: 2006
    ..the stimulation of emergence results in the proteolytic processing of gametocyte surface protein Pfs230 by a cysteine protease and our collaborators have preliminary evidence that the cysteine protease inhibitor, E64d blocks the ..
  49. LISTERIA PHOSPHOLIPASE ACTIVATION & CELL-TO-CELL SPREAD
    HELENE MARQUIS; Fiscal Year: 2002
    ..of pro PC-PLC is mediated by a bacterial metalloprotease (Mpl), which is also active in broth culture, and a cysteine protease, whose activity can only be detected during intracellular infection...
  50. MAST CELL CYSTEINE PROTEASES IN LUNG INFLAMMATION
    Paul Wolters; Fiscal Year: 2003
    ..that tissue mast cells are a major source of dipeptidyl peptidase I (DPPI) and a newly identified 60-kDa cysteine protease and that these proteases participate in inflammation by hydrolyzing extracellular proteins...
  51. CHARACTERIZATION OF A TRYPANSOMA BRUCEI PROTEASE
    Eric Pamer; Fiscal Year: 1991
    ..While studying protein processing by trypanosomal cysteine protease activity when slender trypanosomes differentiate into stumpies. In a laboratory strain of T...
  52. NF-kB Signaling & Molec Pathogenesis of MALT Lymphoma
    Peter Lucas; Fiscal Year: 2006
    ..Bcl10 binds to a novel protein, MALT1, and activates a caspase-like, cysteine protease domain within this protein...
  53. Bleomycin Hydrolase and Alzheimer's Disease
    JOHN LAZO; Fiscal Year: 2004
    ..Recent experimental evidence suggests a unique neutral cysteine protease, bleomycin hydrolase (BH), may have a role in AD...
  54. STRUCTURAL STUDIES OF PROTEINS THAT INHIBIT APOPTOSIS
    Andrew Fisher; Fiscal Year: 2001
    ..Therefore, a better understanding on the structural mechanics of the cysteine protease function and inhibition is required...
  55. Role of endosomal cysteine protease in Ebola and Marburg virus entry
    Kartik Chandran; Fiscal Year: 2009
    ..This work has potential applicability to developing antiviral countermeasures for these highly pathogenic agents. ..
  56. Control of Breast Cancer metastasis by Myeloid Immune Suppressor Cells
    Angela Boutte; Fiscal Year: 2009
    ..Consistent with this observation, MISCs decrease expression of a cysteine protease inhibitor, neutrophilic granule protein (NGP)...
  57. Use of Cystatin C to Combat TGF-Beta Tumorigenesis
    WILLIAM SCHIEMANN; Fiscal Year: 2009
    ..We identified the cysteine protease inhibitor cystatin C (CystC) as a novel TGF-beta type II receptor (TbetaR-II) antagonist that inhibits TGF-..
  58. ABERRANT REGULATION OF CATHEPSIN B EXPRESSION IN TUMORS
    Bonnie Sloane; Fiscal Year: 2005
    DESCRIPTION: (Adapted from the investigator's abstract) Striking increases in expression of the cysteine protease cathepsin B are present in a wide variety of human cancers...
  59. THE CRES GENE IN REPRODUCTION
    Gail Cornwall; Fiscal Year: 2005
    ..studies show that the CRES protein is a new member of the family 2 cystatins of the cystatin superfamily of cysteine protease inhibitors. However, several lines of evidence suggest that CRES may not function as a classic cystatin...
  60. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2005
    ..In our previous studies we identified a cysteine protease inhibitor, onchocystatin, and a cathepsin Z-like cysteine protease, and proposed that they are essential for ..
  61. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..Our studies of PE processing have identified the cysteine protease termed 'prohormone thiol protease'(PTP) as the major PE cleaving activity in enkephalin-containing ..
  62. Haichao Wang; Fiscal Year: 2016
    ..On the other hand, they alter the expression of liver-derived acute phase proteins (APPs), which may similarly participate in the regulation of HMGB1 release...
  63. m-Health for Just-In-Time Occupational Safety Training
    CESAR BANDERA; Fiscal Year: 2011
    ..By addressing obstacles to mobile media interoperability with middleware (instead of with mobile apps), and exploiting cell phone adoption trends, the technology retains its value as new mobile devices are introduced ..
  64. MUCOPOLYSACCHARIDOSES AND CATHEPSIN K
    Dieter Bromme; Fiscal Year: 2007
    ..Cathepsin K is a lysosomal cysteine protease predominantly expressed in osteoclasts and fibroblasts and has been identified as the major bone and ..
  65. Drugs to Elevate Enkephalin as Novel Opiate Analgesics
    Terry Reisine; Fiscal Year: 2004
    ..activity in secretory vesicles for the generation of enkephalin, and it has been demonstrated as the cysteine protease cathepsin L...
  66. Hepatic Responses to Pulmonary Infections
    REBECCA SHARON CHINTHRAJAH; Fiscal Year: 2011
    ..of the cytokines TNF, IL-1, and IL-6 correlates with viral burden and is followed by a dramatic induction of select APPs in the liver...
  67. Lung-Liver Axis During Pneumonia
    Lee Quinton; Fiscal Year: 2012
    ..progression during pneumonia, mechanisms mediating the APR and the collective impact of acute phase proteins (APPs) on inflammation and host defense during pneumonia are unknown...
  68. GENETIC REGULATION OF THE HEPATIC ACUTE PHASE RESPONSE
    Heinz Baumann; Fiscal Year: 2006
    ..Induced production of acute phase proteins (APPs), e.g...