Genomes and Genes
Gene Symbol: CAR
Description: coxsackie virus and adenovirus receptor
Alias: CAR, CAR4/6, HCAR, coxsackievirus and adenovirus receptor, 46 kD coxsackievirus and adenovirus receptor (CAR) protein, CVB3-binding protein, HCVADR, coxsackievirus B-adenovirus receptor
Publications171 found, 100 shown here
- Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transductionK Ray
Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 273:34558-67. 1998The human calcium receptor (hCaR) is a G-protein-coupled receptor containing 11 potential N-linked glycosylation sites in the large extracellular domain...
- Expression of the adenovirus receptor and its interaction with the fiber knobR P Tomko
Skirball Institute of Biomolecular Medicine, New York University Medical Center, 550 First Avenue, New York, New York 10016, USA
Exp Cell Res 255:47-55. 2000The coxsackievirus group B (CVB) and adenovirus (Ad) receptor (HCVADR, formerly HCAR) is a cell surface protein with two immunoglobulin-like regions (IG1 and IG2) that serves as a receptor for two structurally unrelated viruses...
- Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5J M Bergelson
Division of Infectious Diseases, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Science 275:1320-3. 1997A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR)...
- HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackievirusesR P Tomko
Skirball Institute of Biomolecular Medicine, New York University Medical Center, NY 10016, USA
Proc Natl Acad Sci U S A 94:3352-6. 1997..We now describe the isolation of cDNAs from human and mouse that encode the human CVB and Ad2 and 5 receptor (HCAR) and the mouse CVB Ad2 and 5 receptor (MCAR)...
- Purification of the putative coxsackievirus B receptor from HeLa cellsS D Carson
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
Biochem Biophys Res Commun 233:325-8. 1997..Identification of 26 amino acid residues in the protein and corresponding GenBank enteries will accelerate study of CVB tropism and the diseases caused by these viruses...
- The murine CAR homolog is a receptor for coxsackie B viruses and adenovirusesJ M Bergelson
Division of Infectious Diseases, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
J Virol 72:415-9. 1998Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated...
- Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriersH Fechner
Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Freie Universitat, Berlin, Germany
Gene Ther 6:1520-35. 1999..as well as adenovector-mediated gene transfer depends on virus interaction with the Coxsackie adenovirus receptor (CAR) mediating virus attachment to the cell surface, and on interaction with alphavbeta3 and alphavbeta5 integrins ..
- Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor geneK R Bowles
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Genet 105:354-9. 1999..The recent description of the common human Coxsackievirus B-adenovirus receptor (CAR) offers at least a partial explanation...
- Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CARM C Bewley
Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
Science 286:1579-83. 1999..fiber knob domain in complex with domain I of its human cellular receptor, coxsackie and adenovirus receptor (CAR), is presented here. Surface-exposed loops on knob contact one face of CAR, forming a high-affinity complex...
- Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolutionM J van Raaij
European Molecular Biology Laboratory Grenoble Outstation c o Institut Laue Langevin BP 156 F 38042 9, Grenoble Cedex, France
Structure 8:1147-55. 2000The coxsackievirus and adenovirus receptor (CAR) comprises two extracellular immunoglobulin domains, a transmembrane helix and a C-terminal intracellular domain...
- Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sortingC J Cohen
Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
J Biol Chem 276:25392-8. 2001The coxsackievirus and adenovirus receptor (CAR) mediates attachment and infection by coxsackie B viruses and many adenoviruses...
- Receptor for the group B coxsackieviruses and adenoviruses: CARS D Carson
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
Rev Med Virol 11:219-26. 2001Considerable progress towards the characterisation of the long-sought receptor, CAR (coxsackievirus and adenovirus receptor), shared by group B coxsackieviruses (CVB) and most adenoviruses (Ad) has been made since it was isolated and ..
- Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor geneI Thoelen
Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, Minderbroedersstraat 10, BE 3000 Leuven, Belgium
Biochem Biophys Res Commun 287:216-22. 2001The human cellular receptor for group B coxsackieviruses and adenoviruses (HCAR) is a transmembrane glycoprotein which belongs to the immunoglobulin superfamily...
- The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junctionC J Cohen
Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 98:15191-6. 2001The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment and infection, but its physiologic functions have not been described...
- Fatty acid modification of the coxsackievirus and adenovirus receptorWouter van't Hof
Institute of Genetic Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
J Virol 76:6382-6. 2002Membrane-proximal cysteines 259 and 260 in the cytoplasmic tail of the coxsackievirus and adenovirus receptor (CAR) are known to be essential for the tumor suppression activity of CAR...
- Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escapeRobert W Walters
Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
Cell 110:789-99. 2002Adenovirus binds its receptor (CAR), enters cells, and replicates. It must then escape to the environment to infect a new host...
- The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)Kerstin Sollerbrant
Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Intitutet, SE 17177 Stockholm, Sweden
J Biol Chem 278:7439-44. 2003The Coxsackievirus and adenovirus receptor (CAR) functions as a virus receptor, but its primary biological function is unknown...
- Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infectionAndrea Dorner
Department of Medicine, University of California, San Diego, California 92093, USA
J Biol Chem 279:18497-503. 2004The coxsackie-adenovirus receptor (CAR) is a transmembrane receptor of the immunoglobulin superfamily whose expression is altered in myocardial and malignant diseases...
- Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptorsJoshua J Short
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
Virology 322:349-59. 2004..This finding suggests a mechanism whereby viral exploitation of these proteins as receptors may achieve both goals of cellular entry and evading the immune system...
- High-level expression of the coxsackievirus and adenovirus receptor messenger RNA in osteosarcoma, Ewing's sarcoma, and benign neurogenic tumors among musculoskeletal tumorsWenguang Gu
Divisions of Orthopedic Surgery and Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Clin Cancer Res 10:3831-8. 2004..tumor tissues to infection with recombinant adenoviruses correlates with the expression of the coxsackievirus and adenovirus receptor (CAR)...
- A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growthKatherine J D Ashbourne Excoffon
Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
J Cell Sci 117:4401-9. 2004The coxsackie and adenovirus receptor (CAR) plays a role in viral infection, maintenance of the junction adhesion complex in polarized epithelia, and modulation of cellular growth properties...
- The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junctionCarolyn B Coyne
Division of Infectious Diseases, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
J Biol Chem 279:48079-84. 2004The coxsackievirus and adenovirus receptor (CAR) is a component of the epithelial cell tight junction. In a yeast two-hybrid screen we identified the multi-PDZ domain protein MUPP1 as an interaction partner for the CAR cytoplasmic domain...
- Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discsChristian A Shaw
Department of Neurology and Neurosurgery, McGill University and Montreal Neurological Institute, Montreal, Canada
BMC Cell Biol 5:42. 2004The Coxsackie and adenovirus receptor (CAR) has a restricted expression pattern in the adult. In skeletal muscle, although CAR is expressed in immature fibers, its transcript levels are barely detectable in mature muscle...
- The role of the extracellular domain in the biology of the coxsackievirus and adenovirus receptorKatherine J D A Excoffon
Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, 440 EMRB, Iowa City, IA 52242, USA
Am J Respir Cell Mol Biol 32:498-503. 2005The Coxsackievirus B and Adenovirus Receptor (CAR) plays a dual role as a homotypic junctional adhesion protein and as a viral receptor...
- Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophilsKe Zen
Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Mol Biol Cell 16:2694-703. 2005..protein (JAML) regulates transmigration via binding interactions with epithelial coxsackie and adenovirus receptor (CAR)...
- Coxsackie and adenovirus receptor promotes adenocarcinoma cell survival and is expressionally activated after transition from preneoplastic precursor lesions to invasive adenocarcinomasAnsgar Brüning
Department of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, Germany
Clin Cancer Res 11:4316-20. 2005The cell adhesion protein, coxsackie and adenovirus receptor (CAR), is differentially expressed in various human adenocarcinomas...
- The Coxsackie-adenovirus receptor has elevated expression in human breast cancerT A Martin
Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Clin Exp Med 5:122-8. 2005The Coxsackie-adenovirus receptor (CAR) is the primary site for adenovirus attachment during infection and has been used as a delivery mechanism for gene therapies...
- Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptorElena Seiradake
Grenoble Outstation, European Molecular Biology Laboratory, Grenoble, France
J Biol Chem 281:33704-16. 2006Adenovirus fibers from most serotypes bind the D1 domain of coxsackie and adenovirus receptor (CAR), although the binding residues are not strictly conserved...
- Mechanism of increased coxsackie and adenovirus receptor gene expression and adenovirus uptake by phytoestrogen and histone deacetylase inhibitor in human bladder cancer cells and the potential clinical applicationRey Chen Pong
Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
Cancer Res 66:8822-8. 2006Coxsackie and adenovirus receptor (CAR) is known as a principal receptor for adenovirus commonly used as a gene delivery vector. Down-regulation of CAR is often detected in several cancer types...
- Coxsackievirus and adenovirus receptor expression in non-malignant lung tissues and clinical lung cancersYong Wang
Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China
J Mol Histol 37:153-60. 2006..The expression of coxsackievirus adenovirus receptor (CAR), the primary receptor for the most commonly used adenovirus serotype 5 (Ad5)-based vectors, predominantly ..
- The Coxsackie and adenovirus receptor binds microtubules and plays a role in cell migrationPatrick T Fok
Montreal Neurological Institute and Departments of Neurology and Neurosurgery and Experimental Medicine, McGill University, Montreal, Quebec H3A 2B4, Canada
J Biol Chem 282:7512-21. 2007The Coxsackie and adenovirus receptor (CAR), a cell adhesion molecule of the immunoglobulin superfamily, inhibits cell growth of a variety of tumors...
- Soluble isoforms but not the transmembrane form of coxsackie-adenovirus receptor are of clinical relevance in epithelial ovarian cancerDaniel Reimer
Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
Int J Cancer 120:2568-75. 2007The coxsackie-adenovirus receptor (hCAR) has been extensively studied in context of adenoviral-based gene therapy for cancer...
- Overexpression of coxsackie and adenovirus receptor inhibit growth of human bladder cancer cell in vitro and in vivoLin Lin Zhang
Institute of Urology, First Hospital of Xi an Jiaotong University, Xi an 710061, China
Acta Pharmacol Sin 28:895-900. 2007To study the effect of the overexpression of coxsackie and the adenovirus receptor (CAR) on the growth of the human bladder cancer cell in vitro and in vivo.
- Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implicationsCostas T Giaginis
Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Greece
World J Surg Oncol 6:59. 2008The coxsackievirus and adenovirus receptor (CAR) is a crucial receptor for the entry of both coxsackie B viruses and adenoviruses into host cells...
- Expression of coxsackie-adenovirus receptor is related to estrogen sensitivity in breast cancerDoris Auer
Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
Breast Cancer Res Treat 116:103-11. 2009..Expression of transmembrane CAR (hCAR) highly correlated with estrogen receptivity, but was independent of the expression of progesterone receptor (PR)...
- Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heartByung Kwan Lim
Department of Medicine, University of California San Diego, Division of Cardiology, La Jolla, California 92093 0613, USA
J Clin Invest 118:2758-70. 2008The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that belongs to the family of adhesion molecules. In the postnatal heart, it is localized predominantly at the intercalated disc, where its function is not known...
- Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitroBenjamin Vigl
Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli Str 10, CH 8093 Zurich, Switzerland
Exp Cell Res 315:336-47. 2009..Performing comparative gene expression analysis we have recently found that coxsackie- and adenovirus receptor (CAR) is significantly more highly expressed in cultured human, skin-derived lymphatic endothelial cells (LECs), as ..
- The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistributionElena Seiradake
European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France
PLoS Pathog 5:e1000277. 2009..three factors: electrostatic interactions, sialic acid binding and, unexpectedly, binding to the coxsackievirus and adenovirus receptor (CAR) on human erythrocytes...
- Expression and function of the coxsackie and adenovirus receptor in Barrett's esophagus and associated neoplasiaM Anders
Department of Interdisciplinary Endoscopy, University Hospital Hamburg Eppendorf, Hamburg, Germany
Cancer Gene Ther 16:508-15. 2009Cell surface presence of the coxsackie and adenovirus receptor (CAR) is considered a crucial prerequisite for the uptake of attenuated adenovirus...
- Loss of the coxsackie and adenovirus receptor contributes to gastric cancer progressionM Anders
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Charite Medical School, Campus Virchow, Augustenburgerplatz 1, Berlin, Germany
Br J Cancer 100:352-9. 2009Loss of the coxsackie and adenovirus receptor (CAR) has previously been observed in gastric cancer. The role of CAR in gastric cancer pathobiology, however, is unclear...
- CAR mediates efficient tumor engraftment of mesenchymal type lung cancer cellsMysore S Veena
Department of Surgery, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Lab Invest 89:875-86. 2009The coxsackie-adenovirus receptor (CAR) is a developmentally regulated intercellular adhesion molecule that was previously observed to be required for efficient tumor formation...
- Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPKCharlotte Farmer
Division of Asthma, Allergy and Lung Biology, King s College London School of Medicine, 5th Floor Tower Wing, Guy s Hospital Campus, London, UK
Exp Cell Res 315:2637-47. 2009The coxsackie B virus and adenovirus receptor (CAR) is an attachment receptor for Adenovirus serotype 5 (Ad5) and in many cell types forms homodimers with neighbouring cells as part of a cell adhesion complex...
- Downregulation of the coxsackie and adenovirus receptor in cancer cells by hypoxia depends on HIF-1alphaK Küster
Divisions of Gastroenterology and Hepatology, Department of Internal Medicine, Charite Medical School, Campus Virchow, Berlin, Germany
Cancer Gene Ther 17:141-6. 2010Loss of the coxsackie and adenovirus receptor (CAR) has been found in various human cancers. Underlying mechanisms, however, are still poorly understood...
- Loss of Coxsackie and adenovirus receptor downregulates alpha-catenin expressionK Stecker
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Charite Medical School, Campus Virchow, Augustenburgerplatz 1, Berlin 13353, Germany
Br J Cancer 101:1574-9. 2009The Coxsackie and adenovirus receptor (CAR) has been shown to inhibit cancer cell proliferation, migration, and invasion. The underlying mechanisms, however, are poorly understood.
- Isoform-specific regulation and localization of the coxsackie and adenovirus receptor in human airway epitheliaKatherine J D A Excoffon
Department of Biological Sciences, Wright State University, Dayton, Ohio, United States of America
PLoS ONE 5:e9909. 2010..Adenovirus fiber from most serotypes co-opts the Coxsackie-Adenovirus Receptor (CAR) to bind and enter cells...
- The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3KPetra Verdino
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 329:1210-4. 2010Coxsackie and adenovirus receptor (CAR) is the primary cellular receptor for group B coxsackieviruses and most adenovirus serotypes and plays a crucial role in adenoviral gene therapy...
- Novel splice variant CAR 4/6 of the coxsackie adenovirus receptor is differentially expressed in cervical carcinogenesisMarit Dietel
Department of Gynaecology and Obstetrics, Jena University Hospital, Germany
J Mol Med (Berl) 89:621-30. 2011The coxsackie adenovirus receptor (CAR) is a component of the tight junction complex and involved in cell adhesion...
- Impact of the coxsackievirus and adenovirus receptor on the adenoma-carcinoma sequence of colon cancerK Stecker
Department of Internal Medicine, Divisions of Gastroenterology and Hepatology, Charite Medical School, Campus Virchow, Augustenburgerplatz 1, Berlin 13353, Germany
Br J Cancer 104:1426-33. 2011Coxsackie and adenovirus receptor (CAR) has been suggested to function as a tumour suppressor. Its impact on the adenoma-carcinoma sequence of the colon, however, is unclear.
- ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptorMarkus D Lacher
Department of Medicine, Division of Gastroenterology, University of California, San Francisco, CA, USA
Mol Cancer 10:91. 2011..2006 Feb 1;66(3):1648-57) signaling negatively regulate coxsackie virus and adenovirus receptor (CAR) cell-surface expression and adenovirus uptake...
- CAR modulates E-cadherin dynamics in the presence of adenovirus type 5Fawziyah Hussain
Division of Asthma, Allergy and Lung Biology, King s College London, London, United Kingdom
PLoS ONE 6:e23056. 2011Adenovirus (Ad) serotype 5 (Ad5) fiber competitively binds to the coxsackievirus and Ad receptor (CAR) to attach Ad5 to target cells and also disrupts cell junctions and facilitates virus escape at a late stage in Ad5 infection...
- Expression of the coxsackie and adenovirus receptor in human lung cancersZhaoli Chen
Department of Health and Environment, Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No 1, Dali Road, Tianjin, 300050, People s Republic of China
Tumour Biol 34:17-24. 2013The aim of this study is to elucidate the relation between expression of coxsackie and adenovirus receptor (CAR) and formation of lung cancer...
- Back pain in a large Canadian police forceJ J Brown
Department of Medicine, University of Ottawa, Ontario, Canada
Spine (Phila Pa 1976) 23:821-7. 1998..back pain among Royal Canadian Mounted Police members and to assess the validity of the perception that the patrol car seat and the duty belt are causing a higher rate of low back pain among members of the Royal Canadian Mounted ..
- Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CARW Xie
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Genes Dev 14:3014-23. 2000..and genetically to activate CYP3A genes, while similar studies have established constitutive androstane receptor (CAR) as a CYP2B regulator...
- [Significance of a screening questionnaire for diagnosis of sleep apnea]T Ploch
Medizinische Poliklinik, Zeitreihenlabor, , Marburg
Pneumologie 47:108-11. 1993..pills, hypertension, snoring, involuntary falling asleep, respiratory standstills, tendency to fall asleep during car driving and accidents in which the tendency to fall asleep was also involved...
- In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonistsA D Medhurst
Department of Neurosciences Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex
Br J Pharmacol 122:469-76. 1997..4, slope=1.8+/-0.3, n=4). SB 222200 ((-)-(S)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car box amide; 30-300 nM, pA2=7.9, slope=1.4+/-0...
- Psychosocial job factors, physical workload, and incidence of work-related spinal injury: a 5-year prospective study of urban transit operatorsN Krause
Division of Epidemiology, School of Public Health, University of California, Berkeley, USA
Spine (Phila Pa 1976) 23:2507-16. 1998..7-fold reduced risk for spinal injury (OR, 0.37; 95% CI, 0.15-0.93). Cable car crews performing the heaviest physical labor had a threefold increased risk of spinal injury compared with bus ..
- We are chronically sleep deprivedM H Bonnet
Dayton Veterans Affairs Medical Center, Wright State University, Ohio, USA
Sleep 18:908-11. 1995..surprising that fatigue is a factor in 57% of accidents leading to the death of a truck driver and in 10% of fatal car accidents and results in costs of up to 56 billion dollars per year...
- The long-range prognosis of arachnoiditisD W Guyer
Vancouver Orthopaedic Group, Washington
Spine (Phila Pa 1976) 14:1332-41. 1989..Although the majority were able to walk and drive a car without limitation, ability to return to previous full-time occupations was markedly limited...
- Validity of patient reporting and predictive value of industrial physical work demandsI Lindström
Department of Orthopaedics, University of Goteborg, Sahlgren Hospital, Sweden
Spine (Phila Pa 1976) 19:888-93. 1994This prospective study analyzed industrial physical work demands. The patients (n = 103), sick-listed 8 weeks because of low back pain, were industrial blue-collar workers in the car manufacturing industry.
- High-dose methylprednisolone prevents extensive sick leave after whiplash injury. A prospective, randomized, double-blind studyK Pettersson
Department of Orthopaedics, , Sweden
Spine (Phila Pa 1976) 23:984-9. 1998..This procedure was also adopted in a randomized study of cases of whiplash injury in car accidents...
- Hydroxycinnamate (hca) catabolic genes from Acinetobacter sp. strain ADP1 are repressed by HcaR and are induced by hydroxycinnamoyl-coenzyme A thioestersDonna Parke
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103, USA
Appl Environ Microbiol 69:5398-409. 2003..Sequence analysis of the newly cloned DNA identified five open reading frames designated hcaA, hcaB, hcaK, hcaR, and ORF1...
- Evaluation "in-car" countermeasures to sleepiness: cold air and radioL A Reyner
Sleep Research Laboratory, Loughborough University, UK
Sleep 21:46-50. 1998The efficacy of putative "in-car" countermeasures to driver sleepiness is unknown...
- A patient-reported comparison of trapeziectomy with Swanson Silastic implant or sling ligament reconstructionM E Lovell
Centre for Upper Limb Surgery, Wrightington Hospital, Appley Bridge, UK
J Hand Surg Br 24:453-5. 1999..significantly better results were obtained for pain at 1 year, carrying a milk bottle and taking a handbrake off a car, and overall function...
- Profiling histidine-containing dipeptides in rat tissues by liquid chromatography/electrospray ionization tandem mass spectrometryGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Mass Spectrom 39:1417-28. 2004The histidine-containing dipeptides carnosine (CAR) and structurally related anserine (ANS) and homocarnosine (HCAR), widely distributed in vertebrate organisms, have recently been proposed as endogenous quenchers for highly cytotoxic ..
- Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1)Xinrong Chen
Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
Toxicology 231:224-33. 2007..Nuclear receptor co-transfection results indicated that human constitutive androstane receptor (hCAR) and human retinoid X receptor alpha (hRXRalpha) were involved in the transcriptional regulation of hSULT2A1...
- Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptorKaoru Kobayashi
Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba 260 8675, Japan
Drug Metab Dispos 33:924-9. 2005..is a potent mouse CAR ligand that has been used to study CAR target genes in mice but does not activate human CAR (hCAR) or rat CAR (rCAR)...
- hCAR-EGFP fusion receptor in human follicular lymphoma B cells - a model for adenoviral gene therapy for B cell malignanciesMikko Mättö
Department of Clinical Microbiology, University of Kuopio, Finland
Int J Mol Med 17:1057-62. 2006..More importantly, most tumor cells derived from B cell lineage express a very low level of the adenovirus receptor hCAR; thus, warranting the design of adenoviral vectors with high affinity to abundant B cell surface molecules...
- Asbestos exposure, physical activity and colon cancer: a case-control studyP Vineis
Dipartimento di Scienze Biomediche e Oncologia Umana, Main Hospital and University of Torino, Italy
Tumori 79:301-3. 1993AIMS AND BACKGROUND: An association between colon cancer and the occupation of model or pattern maker in the car industry has been repeatedly suggested...
- Mectizan delivery systems and cost recovery in the Central African RepublicA D Hopkins
, Bangui, Central African Republic
Ann Trop Med Parasitol 92:S97-100. 1998The Central African Republic (CAR) has a serious onchocerciasis problem. The disease is endemic in three quarters of the country and there is considerable onchocercal blindness in the north-west...
- Ca(2+)-evoked serotonin secretion by parafollicular cells: roles in signal transduction of phosphatidylinositol 3'-kinase, and the gamma and zeta isoforms of protein kinase CK Liu
Division of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
J Neurosci 20:1365-73. 2000Parafollicular (PF) cells secrete 5-HT in response to stimulation of a G-protein-coupled Ca(2+) receptor (CaR) by increased extracellular Ca(2+) (upward arrow[Ca(2+)](e))...
- The HcaR regulatory protein of Photorhabdus luminescens affects the production of proteins involved in oxidative stress and toxemiaSabina Chalabaev
Unite de Genetique des Genomes Bacteriens URA2171, Institut Pasteur, Paris, France
Proteomics 7:4499-510. 2007Comparison of the proteomes of wild-type Photorhabdus luminescens and its hcaR derivative, grown in insect hemolymph, showed that hcaR disruption decreased the production of toxins (tcdA1, mcf, and pirAB) and proteins involved in ..
- Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking regionKouichi Yoshinari
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aramaki aoba, Aoba ku, Sendai, Miyagi 980 8578, Japan
Biochem Pharmacol 79:261-9. 2010..In this system, human CAR (hCAR) enhanced the transcription of both genes through common promoter regions from -461 to -554 and from -18089 to -..
- Family history of hypertension and left ventricular mass in youth: possible mediating parametersB B Cook
Department of Pediatrics, Medical College of Georgia, Augusta, USA
Am J Hypertens 14:351-6. 2001..Hemodynamics were measured at rest and during four stressors (ie, postural change, car driving simulation, video game, forehead cold)...
- Gene expression networks underlying retinoic acid-induced differentiation of human retinoblastoma cellsAimin Li
Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, and Department of Cell and Neurobiology, The Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9112, USA
Invest Ophthalmol Vis Sci 44:996-1007. 2003..To understand the genetic regulatory pathways underlying the retinoic acid (RA) induction of cone arrestin, gene array technology and other molecular tools were used to profile global gene expression changes in human retinoblastoma cells...
- CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retinaCaroline J Zeiss
Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, New Haven, CT 06510, USA
Exp Eye Res 82:395-404. 2006..Immunohistochemistry was performed on a subset of 11 dogs for expression of rhodopsin, human cone arrestin (hCAR) and recoverin...
- Secretion and organization of a cornea-like tissue in vitro by stem cells from human corneal stromaYiqin Du
Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2588, USA
Invest Ophthalmol Vis Sci 48:5038-45. 2007..To investigate the potential of human corneal stromal stem cells to assume a keratocyte phenotype and to organize extracellular matrix (ECM) in vitro similar to corneal stromal tissue...
- Sick leave and disability pension among passenger car occupants injured in urban trafficP O Bylund
, Department of Surgery, , Sweden
Spine (Phila Pa 1976) 23:1023-8. 1998STUDY DESIGN: A follow-up cohort study of passenger car occupants injured in car crashes in an urban area in Sweden. OBJECTIVES: To analyze the injuries, injury events, and long-term consequences of injuries in car crashes...
- Alternative splicing within the ligand binding domain of the human constitutive androstane receptorRajesh S Savkur
Gene Regulation Research, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA
Mol Genet Metab 80:216-26. 2003The human constitutive androstane receptor (hCAR; NR1I3) is a member of the nuclear receptor superfamily. The activity of hCAR is regulated by a variety of xenobiotics including clotrimazole and acetaminophen metabolites...
- Mothers' experience with household roles and social support during the first postpartum yearD K Gjerdingen
Department of Family Practice and Community Health, University of Minnesota
Women Health 21:57-74. 1994..certain household chores (house cleaning, grocery shopping, cooking, washing clothes and dishes, household repairs, car maintenance, and garbage removal)...
- Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transferR J Pickles
CF Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, 27599 7248, USA
J Virol 74:6050-7. 2000..The human coxsackievirus and adenovirus receptor (hCAR) was detected by immunofluorescence selectively at the basolateral surfaces of freshly ..
- [Traumatic tricuspid insufficiency. 5 cases]J M Quatre
Service de cardiologie, , Paris
Arch Mal Coeur Vaiss 81:325-30. 1988..years) were followed up for 6 to 60 months for tricuspid valve regurgitation caused by a front-to-back injury (in a car in four cases, in an aircraft in one case)...
- Decreased width of the spinal canal in patients with chronic symptoms after whiplash injuryK Pettersson
Department of Orthopaedics, University Hospital of Northern Sweden, , Sweden
Spine (Phila Pa 1976) 20:1664-7. 1995..METHODS. Forty-eight consecutive patients were evaluated for whiplash trauma after car accidents...
- Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12E Diaz
Department of Molecular Microbiology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, 28006 Madrid, Spain
J Bacteriol 180:2915-23. 1998..two additional genes transcribed in the opposite direction that encode a potential permease (hcaT) and a regulator (hcaR)...
- Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptorAntonia H Tolson
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, MD 21201, USA
Drug Metab Dispos 37:1887-94. 2009..MD significantly increased human (h) PXR-mediated CYP2B6 reporter activities but exhibited minimal effect on hCAR activation as a result of the constitutive activity of hCAR in HepG2 cells...
- Coordinating cognitive information: task effects and individual differences in integrating information from several sourcesP L Yee
University of Washington
Cogn Psychol 23:615-80. 1991In many tasks people have to coordinate the information from several sources. An example would be driving a car while listening to directions. The driver has to establish a correspondence between a visual picture and verbal instructions...
- Haemodynamic changes in patients with whiplash injury measured by transcranial Doppler sonography (TCD)V Seric
Department of Neurology, Sestre Milosrdnice University Hospital, Zagreb, Croatia
Coll Antropol 24:197-204. 2000..of vertebrobasilar circulation in patients with a whiplash injury of the cervical spine, that occurred mostly in car accident...
- Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agentKatalin Monostory
Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary
Drug Metab Dispos 37:375-85. 2009..Rosuvastatin was found to increase human constitutive androstane receptor (hCAR)-mediated transcription of CYP3A4, CYP2C9, and CYP2B6 genes, predicting the consequent potential for drug ..
- Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarctionConnie R Bezzina
Department of Experimental Cardiology, University of Amsterdam, Amsterdam, The Netherlands
Nat Genet 42:688-91. 2010..This locus has not previously been implicated in arrhythmia susceptibility...
- 2,4-Dinitro-3,5,6-trideuterophenylhydrazones for the quantitation of aldehydes and ketones in air samples by liquid chromatography-mass spectrometryG Zurek
, Anorganisch-Chemisches Institut, Abteilung Analytische Chemie, Germany
J Chromatogr A 869:251-9. 2000..of a series of aldehydes and ketones are applied as internal standards for the determination of the carbonyls in car exhaust samples. Various aldehydes are identified and quantified by MS detection...
- The interaction between technical requirements and comfort in care seatingE Fubini
Department of Animal Biology, University of Torino, Italy
Coll Antropol 21:405-27. 1997The paper analyses different ergonomic aspects that it is necessary to take into account to design car seats tat can fit users' requirements in terms of safety and comfort, two aspects that are closely related...
- Differential transactivation by two isoforms of the orphan nuclear hormone receptor CARH S Choi
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Biol Chem 272:23565-71. 1997..termed mCAR, that is closely related to the previously described human orphan MB67, referred to here as hCAR. Like hCAR, mCAR expression is highest in liver...
- Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoformsJean Marc Pascussi
INSERM, U632, Montpellier, France
Hepatology 45:1146-53. 2007..In this work, we analyzed the expression of human CAR (hCAR) in normal liver during development and in hepatocellular carcinoma (HCC) and investigated the effect of hepatocyte ..
- Characterization of the porcine constitutive androstane receptor (CAR) and its splice variantsM A Gray
Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
Xenobiotica 39:915-30. 2009..androstane receptor (CAR; NR1I3) was cloned and compared for homology and activity with mouse and human CAR (mCAR, hCAR). Porcine CAR (pgCAR) was 86% and 75% homologous to hCAR at the nucleotide and protein levels...
- Determination of benzene, toluene, ethylbenzene and xylenes in indoor air at environmental levels using diffusive samplers in combination with headspace solid-phase microextraction and high-resolution gas chromatography-flame ionization detectionK Elke
, Department of Analytical Chemistry, , Germany
J Chromatogr A 826:191-200. 1998..Applications such as the determination of BTEXs in indoor air inside buildings, inside a train and a car are presented, indicating the usefulness of the described procedure for short-term measurements of environmental ..
- Chiral beta-cyclodextrin-based polymer supports prepared via ring-opening metathesis graft-polymerizationB Mayr
Institute of Analytical Chemistry and Radiochemistry, University of Innsbruck, Austria
J Chromatogr A 907:47-56. 2001..1), tetrakis(6-O-norborn-2-ene-5-carboxyl)-beta-CD (2), (3), 6-O-(6-norborn-2-ene-5-car-6-O-(7-oxanorborn-2-ene-5-carboxyl)-beta-CD bonylaminohexoyl)-beta-CD (4), 6-O-(norborn-2-ene-5-..
- Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytesHongbing Wang
Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Drug Metab Dispos 31:620-30. 2003..In hGR and human constitutive androstane receptor (hCAR) cotransfection assays, activated hGR increased the constitutive activation of PBREM reporter constructs by hCAR in ..
- Amino acids important for ligand specificity of the human constitutive androstane receptorJohanna Jyrkkärinne
Department of Pharmaceutics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
J Biol Chem 280:5960-71. 2005The human constitutive androstane receptor (CAR, NR1I3) is an important ligand-activated regulator of oxidative and conjugative enzymes and transport proteins...
- Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectorsM Everts
Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
Gene Ther 12:1042-8. 2005..Therefore, we have exploited mice transgenic for the human coxsackie and adenovirus receptor (hCAR) to establish a new model for transient expression of human tumor-associated antigens in the pulmonary vasculature...
- Cigarette smoke extract induces CYP2B6 through constitutive androstane receptor in hepatocytesIkumi Washio
Department of Clinical Pharmacology and Pharmacogenomics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
Drug Metab Dispos 39:1-3. 2011..preparing cigarette smoke extract (CSE), we addressed the possibility that human constitutive androstane receptor (hCAR) is involved in smoking-mediated induction of CYP2B6...
- Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic ApplicationsHanni Uusi-Kerttula
Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Viruses 7:6009-42. 2015..Active tumor targeting is also hampered by the ubiquitous nature of the Ad5 receptor, hCAR, as well as the lack of highly tumor-selective targeting ligands and suitable targeting strategies...
- Membrane Dynamics and Signaling of the Coxsackievirus and Adenovirus ReceptorFabien Loustalot
Institut de Genetique Moleculaire de Montpellier, Universite de Montpellier, Montpellier, France
Int Rev Cell Mol Biol 322:331-62. 2016The coxsackievirus and adenovirus receptor (CAR) belongs to the immunoglobulin superfamily and acts as a receptor for some adenovirus types and group B coxsackieviruses...
- Expression of the coxsackievirus and adenovirus receptorChristopher Cohen; Fiscal Year: 2002..Group B coxsackieviruses and many adenoviruses initiate infection by binding to the coxsackievirus and adenovirus receptor (CAR)...
- Hongbing Wang; Fiscal Year: 2016..Towards this end, we have shown that activation of the human constitutive androstane receptor (hCAR) preferentially induced the expression of hepatic CYP2B6 over CYP3A4 and increased the formation of 4-OH-CPA...
- Metallothionein & Cadmium Carcinogenesis in the ProstateShuk Mei Ho; Fiscal Year: 2006..Part-2 By cross-breeding with a mouse, named CAR, which expresses membrane Coxsackie/human Adenovirus Receptors (hCAR) on all body cells, with PBMT-1 we will generated the CAR/PBMT-1 mouse...
- MYOCARDITIS--RECEPTORS FOR A CARDIOTROPIC VIRUSJeffrey Bergelson; Fiscal Year: 2001..We have now purified and cloned another- --novel---cell surface protein, CAR, that functions both in attachment and infection by all six coxsackie B serotypes...
- Naturalization-Resistant Adenovirus Vaccine VectorJeffrey Bergelson; Fiscal Year: 2005..Such a chimeric vector could solve one of the major obstacles to the use of adenovirus vectors for HIV immunization. ..
- Junction Adhesion Molecule CAR and the Immune SystemSteven Carson; Fiscal Year: 2007b>CAR is a junction adhesion molecule (JAM), similar to other known JAM proteins. These proteins generally localize to tight junctions, where they participate in cell-cell adhesion and link to cytoplasmic proteins...
- MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICECaroline Zeiss; Fiscal Year: 2007..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
- Cell Biology of Enterovirus Infection in Polarized Epithelial CellsJeffrey Bergelson; Fiscal Year: 2007..leads to actin rearangements and virus movement to the tight junction, where interaction with the coxsackievirus and adenovirus receptor (CAR) initiates the uncoating process that releases viral RNA; activation of Fyn kinase triggers ..
- Mechanisms of Cone Pigment DeactivationCheryl Craft; Fiscal Year: 2009..pathway and to accomplish our goals, experiments are designed to explore the function(s) of cone arrestin (CAR), its targeted G protein-coupled receptors (S and M opsin pigments) and other potential relevant partners in the ..