CAR

Summary

Gene Symbol: CAR
Description: coxsackie virus and adenovirus receptor
Alias: CAR, CAR4/6, HCAR, coxsackievirus and adenovirus receptor, 46 kD coxsackievirus and adenovirus receptor (CAR) protein, CVB3-binding protein, HCVADR, coxsackievirus B-adenovirus receptor
Species: human

Top Publications

  1. ncbi Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction
    K Ray
    Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:34558-67. 1998
  2. ncbi Expression of the adenovirus receptor and its interaction with the fiber knob
    R P Tomko
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, 550 First Avenue, New York, New York 10016, USA
    Exp Cell Res 255:47-55. 2000
  3. ncbi Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 275:1320-3. 1997
  4. pmc HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
    R P Tomko
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, NY 10016, USA
    Proc Natl Acad Sci U S A 94:3352-6. 1997
  5. ncbi Purification of the putative coxsackievirus B receptor from HeLa cells
    S D Carson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
    Biochem Biophys Res Commun 233:325-8. 1997
  6. pmc The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 72:415-9. 1998
  7. ncbi Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers
    H Fechner
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Freie Universitat, Berlin, Germany
    Gene Ther 6:1520-35. 1999
  8. ncbi Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor gene
    K R Bowles
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Genet 105:354-9. 1999
  9. ncbi Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR
    M C Bewley
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Science 286:1579-83. 1999
  10. ncbi Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution
    M J van Raaij
    European Molecular Biology Laboratory Grenoble Outstation c o Institut Laue Langevin BP 156 F 38042 9, Grenoble Cedex, France
    Structure 8:1147-55. 2000

Research Grants

  1. Expression of the coxsackievirus and adenovirus receptor
    Christopher Cohen; Fiscal Year: 2002
  2. Hongbing Wang; Fiscal Year: 2016
  3. Metallothionein & Cadmium Carcinogenesis in the Prostate
    Shuk Mei Ho; Fiscal Year: 2006
  4. MYOCARDITIS--RECEPTORS FOR A CARDIOTROPIC VIRUS
    Jeffrey Bergelson; Fiscal Year: 2001
  5. Naturalization-Resistant Adenovirus Vaccine Vector
    Jeffrey Bergelson; Fiscal Year: 2005
  6. Junction Adhesion Molecule CAR and the Immune System
    Steven Carson; Fiscal Year: 2007
  7. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2007
  8. Cell Biology of Enterovirus Infection in Polarized Epithelial Cells
    Jeffrey Bergelson; Fiscal Year: 2007
  9. Mechanisms of Cone Pigment Deactivation
    Cheryl Craft; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications171 found, 100 shown here

  1. ncbi Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction
    K Ray
    Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:34558-67. 1998
    The human calcium receptor (hCaR) is a G-protein-coupled receptor containing 11 potential N-linked glycosylation sites in the large extracellular domain...
  2. ncbi Expression of the adenovirus receptor and its interaction with the fiber knob
    R P Tomko
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, 550 First Avenue, New York, New York 10016, USA
    Exp Cell Res 255:47-55. 2000
    The coxsackievirus group B (CVB) and adenovirus (Ad) receptor (HCVADR, formerly HCAR) is a cell surface protein with two immunoglobulin-like regions (IG1 and IG2) that serves as a receptor for two structurally unrelated viruses...
  3. ncbi Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 275:1320-3. 1997
    A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR)...
  4. pmc HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
    R P Tomko
    Skirball Institute of Biomolecular Medicine, New York University Medical Center, NY 10016, USA
    Proc Natl Acad Sci U S A 94:3352-6. 1997
    ..We now describe the isolation of cDNAs from human and mouse that encode the human CVB and Ad2 and 5 receptor (HCAR) and the mouse CVB Ad2 and 5 receptor (MCAR)...
  5. ncbi Purification of the putative coxsackievirus B receptor from HeLa cells
    S D Carson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198, USA
    Biochem Biophys Res Commun 233:325-8. 1997
    ..Identification of 26 amino acid residues in the protein and corresponding GenBank enteries will accelerate study of CVB tropism and the diseases caused by these viruses...
  6. pmc The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
    J M Bergelson
    Division of Infectious Diseases, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 72:415-9. 1998
    Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated...
  7. ncbi Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers
    H Fechner
    Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Freie Universitat, Berlin, Germany
    Gene Ther 6:1520-35. 1999
    ..as well as adenovector-mediated gene transfer depends on virus interaction with the Coxsackie adenovirus receptor (CAR) mediating virus attachment to the cell surface, and on interaction with alphavbeta3 and alphavbeta5 integrins ..
  8. ncbi Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor gene
    K R Bowles
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Genet 105:354-9. 1999
    ..The recent description of the common human Coxsackievirus B-adenovirus receptor (CAR) offers at least a partial explanation...
  9. ncbi Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR
    M C Bewley
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Science 286:1579-83. 1999
    ..fiber knob domain in complex with domain I of its human cellular receptor, coxsackie and adenovirus receptor (CAR), is presented here. Surface-exposed loops on knob contact one face of CAR, forming a high-affinity complex...
  10. ncbi Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution
    M J van Raaij
    European Molecular Biology Laboratory Grenoble Outstation c o Institut Laue Langevin BP 156 F 38042 9, Grenoble Cedex, France
    Structure 8:1147-55. 2000
    The coxsackievirus and adenovirus receptor (CAR) comprises two extracellular immunoglobulin domains, a transmembrane helix and a C-terminal intracellular domain...
  11. ncbi Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting
    C J Cohen
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Biol Chem 276:25392-8. 2001
    The coxsackievirus and adenovirus receptor (CAR) mediates attachment and infection by coxsackie B viruses and many adenoviruses...
  12. ncbi Receptor for the group B coxsackieviruses and adenoviruses: CAR
    S D Carson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 6495, USA
    Rev Med Virol 11:219-26. 2001
    Considerable progress towards the characterisation of the long-sought receptor, CAR (coxsackievirus and adenovirus receptor), shared by group B coxsackieviruses (CVB) and most adenoviruses (Ad) has been made since it was isolated and ..
  13. ncbi Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene
    I Thoelen
    Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, Minderbroedersstraat 10, BE 3000 Leuven, Belgium
    Biochem Biophys Res Commun 287:216-22. 2001
    The human cellular receptor for group B coxsackieviruses and adenoviruses (HCAR) is a transmembrane glycoprotein which belongs to the immunoglobulin superfamily...
  14. pmc The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
    C J Cohen
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:15191-6. 2001
    The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment and infection, but its physiologic functions have not been described...
  15. pmc Fatty acid modification of the coxsackievirus and adenovirus receptor
    Wouter van't Hof
    Institute of Genetic Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Virol 76:6382-6. 2002
    Membrane-proximal cysteines 259 and 260 in the cytoplasmic tail of the coxsackievirus and adenovirus receptor (CAR) are known to be essential for the tumor suppression activity of CAR...
  16. ncbi Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape
    Robert W Walters
    Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Cell 110:789-99. 2002
    Adenovirus binds its receptor (CAR), enters cells, and replicates. It must then escape to the environment to infect a new host...
  17. ncbi The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX)
    Kerstin Sollerbrant
    Ludwig Institute for Cancer Research, Stockholm Branch, Karolinska Intitutet, SE 17177 Stockholm, Sweden
    J Biol Chem 278:7439-44. 2003
    The Coxsackievirus and adenovirus receptor (CAR) functions as a virus receptor, but its primary biological function is unknown...
  18. ncbi Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection
    Andrea Dorner
    Department of Medicine, University of California, San Diego, California 92093, USA
    J Biol Chem 279:18497-503. 2004
    The coxsackie-adenovirus receptor (CAR) is a transmembrane receptor of the immunoglobulin superfamily whose expression is altered in myocardial and malignant diseases...
  19. ncbi Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors
    Joshua J Short
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Virology 322:349-59. 2004
    ..This finding suggests a mechanism whereby viral exploitation of these proteins as receptors may achieve both goals of cellular entry and evading the immune system...
  20. ncbi High-level expression of the coxsackievirus and adenovirus receptor messenger RNA in osteosarcoma, Ewing's sarcoma, and benign neurogenic tumors among musculoskeletal tumors
    Wenguang Gu
    Divisions of Orthopedic Surgery and Cell Biology and Molecular Pharmacology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Clin Cancer Res 10:3831-8. 2004
    ..tumor tissues to infection with recombinant adenoviruses correlates with the expression of the coxsackievirus and adenovirus receptor (CAR)...
  21. ncbi A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth
    Katherine J D Ashbourne Excoffon
    Department of Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Cell Sci 117:4401-9. 2004
    The coxsackie and adenovirus receptor (CAR) plays a role in viral infection, maintenance of the junction adhesion complex in polarized epithelia, and modulation of cellular growth properties...
  22. ncbi The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction
    Carolyn B Coyne
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:48079-84. 2004
    The coxsackievirus and adenovirus receptor (CAR) is a component of the epithelial cell tight junction. In a yeast two-hybrid screen we identified the multi-PDZ domain protein MUPP1 as an interaction partner for the CAR cytoplasmic domain...
  23. pmc Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs
    Christian A Shaw
    Department of Neurology and Neurosurgery, McGill University and Montreal Neurological Institute, Montreal, Canada
    BMC Cell Biol 5:42. 2004
    The Coxsackie and adenovirus receptor (CAR) has a restricted expression pattern in the adult. In skeletal muscle, although CAR is expressed in immature fibers, its transcript levels are barely detectable in mature muscle...
  24. pmc The role of the extracellular domain in the biology of the coxsackievirus and adenovirus receptor
    Katherine J D A Excoffon
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, 440 EMRB, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 32:498-503. 2005
    The Coxsackievirus B and Adenovirus Receptor (CAR) plays a dual role as a homotypic junctional adhesion protein and as a viral receptor...
  25. pmc Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils
    Ke Zen
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:2694-703. 2005
    ..protein (JAML) regulates transmigration via binding interactions with epithelial coxsackie and adenovirus receptor (CAR)...
  26. ncbi Coxsackie and adenovirus receptor promotes adenocarcinoma cell survival and is expressionally activated after transition from preneoplastic precursor lesions to invasive adenocarcinomas
    Ansgar Brüning
    Department of Obstetrics and Gynecology, Ludwig Maximilians University, Munich, Germany
    Clin Cancer Res 11:4316-20. 2005
    The cell adhesion protein, coxsackie and adenovirus receptor (CAR), is differentially expressed in various human adenocarcinomas...
  27. ncbi The Coxsackie-adenovirus receptor has elevated expression in human breast cancer
    T A Martin
    Metastasis and Angiogenesis Research Group, University Department of Surgery, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Clin Exp Med 5:122-8. 2005
    The Coxsackie-adenovirus receptor (CAR) is the primary site for adenovirus attachment during infection and has been used as a delivery mechanism for gene therapies...
  28. ncbi Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor
    Elena Seiradake
    Grenoble Outstation, European Molecular Biology Laboratory, Grenoble, France
    J Biol Chem 281:33704-16. 2006
    Adenovirus fibers from most serotypes bind the D1 domain of coxsackie and adenovirus receptor (CAR), although the binding residues are not strictly conserved...
  29. ncbi Mechanism of increased coxsackie and adenovirus receptor gene expression and adenovirus uptake by phytoestrogen and histone deacetylase inhibitor in human bladder cancer cells and the potential clinical application
    Rey Chen Pong
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
    Cancer Res 66:8822-8. 2006
    Coxsackie and adenovirus receptor (CAR) is known as a principal receptor for adenovirus commonly used as a gene delivery vector. Down-regulation of CAR is often detected in several cancer types...
  30. ncbi Coxsackievirus and adenovirus receptor expression in non-malignant lung tissues and clinical lung cancers
    Yong Wang
    Changzhou Second Hospital, Nanjing Medical University, Jiangsu, China
    J Mol Histol 37:153-60. 2006
    ..The expression of coxsackievirus adenovirus receptor (CAR), the primary receptor for the most commonly used adenovirus serotype 5 (Ad5)-based vectors, predominantly ..
  31. ncbi The Coxsackie and adenovirus receptor binds microtubules and plays a role in cell migration
    Patrick T Fok
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery and Experimental Medicine, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 282:7512-21. 2007
    The Coxsackie and adenovirus receptor (CAR), a cell adhesion molecule of the immunoglobulin superfamily, inhibits cell growth of a variety of tumors...
  32. ncbi Soluble isoforms but not the transmembrane form of coxsackie-adenovirus receptor are of clinical relevance in epithelial ovarian cancer
    Daniel Reimer
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Int J Cancer 120:2568-75. 2007
    The coxsackie-adenovirus receptor (hCAR) has been extensively studied in context of adenoviral-based gene therapy for cancer...
  33. ncbi Overexpression of coxsackie and adenovirus receptor inhibit growth of human bladder cancer cell in vitro and in vivo
    Lin Lin Zhang
    Institute of Urology, First Hospital of Xi an Jiaotong University, Xi an 710061, China
    Acta Pharmacol Sin 28:895-900. 2007
    To study the effect of the overexpression of coxsackie and the adenovirus receptor (CAR) on the growth of the human bladder cancer cell in vitro and in vivo.
  34. pmc Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications
    Costas T Giaginis
    Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Greece
    World J Surg Oncol 6:59. 2008
    The coxsackievirus and adenovirus receptor (CAR) is a crucial receptor for the entry of both coxsackie B viruses and adenoviruses into host cells...
  35. doi Expression of coxsackie-adenovirus receptor is related to estrogen sensitivity in breast cancer
    Doris Auer
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Breast Cancer Res Treat 116:103-11. 2009
    ..Expression of transmembrane CAR (hCAR) highly correlated with estrogen receptivity, but was independent of the expression of progesterone receptor (PR)...
  36. pmc Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart
    Byung Kwan Lim
    Department of Medicine, University of California San Diego, Division of Cardiology, La Jolla, California 92093 0613, USA
    J Clin Invest 118:2758-70. 2008
    The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that belongs to the family of adhesion molecules. In the postnatal heart, it is localized predominantly at the intercalated disc, where its function is not known...
  37. doi Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro
    Benjamin Vigl
    Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli Str 10, CH 8093 Zurich, Switzerland
    Exp Cell Res 315:336-47. 2009
    ..Performing comparative gene expression analysis we have recently found that coxsackie- and adenovirus receptor (CAR) is significantly more highly expressed in cultured human, skin-derived lymphatic endothelial cells (LECs), as ..
  38. pmc The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution
    Elena Seiradake
    European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France
    PLoS Pathog 5:e1000277. 2009
    ..three factors: electrostatic interactions, sialic acid binding and, unexpectedly, binding to the coxsackievirus and adenovirus receptor (CAR) on human erythrocytes...
  39. doi Expression and function of the coxsackie and adenovirus receptor in Barrett's esophagus and associated neoplasia
    M Anders
    Department of Interdisciplinary Endoscopy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer Gene Ther 16:508-15. 2009
    Cell surface presence of the coxsackie and adenovirus receptor (CAR) is considered a crucial prerequisite for the uptake of attenuated adenovirus...
  40. pmc Loss of the coxsackie and adenovirus receptor contributes to gastric cancer progression
    M Anders
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Charite Medical School, Campus Virchow, Augustenburgerplatz 1, Berlin, Germany
    Br J Cancer 100:352-9. 2009
    Loss of the coxsackie and adenovirus receptor (CAR) has previously been observed in gastric cancer. The role of CAR in gastric cancer pathobiology, however, is unclear...
  41. doi CAR mediates efficient tumor engraftment of mesenchymal type lung cancer cells
    Mysore S Veena
    Department of Surgery, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Lab Invest 89:875-86. 2009
    The coxsackie-adenovirus receptor (CAR) is a developmentally regulated intercellular adhesion molecule that was previously observed to be required for efficient tumor formation...
  42. doi Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK
    Charlotte Farmer
    Division of Asthma, Allergy and Lung Biology, King s College London School of Medicine, 5th Floor Tower Wing, Guy s Hospital Campus, London, UK
    Exp Cell Res 315:2637-47. 2009
    The coxsackie B virus and adenovirus receptor (CAR) is an attachment receptor for Adenovirus serotype 5 (Ad5) and in many cell types forms homodimers with neighbouring cells as part of a cell adhesion complex...
  43. doi Downregulation of the coxsackie and adenovirus receptor in cancer cells by hypoxia depends on HIF-1alpha
    K Küster
    Divisions of Gastroenterology and Hepatology, Department of Internal Medicine, Charite Medical School, Campus Virchow, Berlin, Germany
    Cancer Gene Ther 17:141-6. 2010
    Loss of the coxsackie and adenovirus receptor (CAR) has been found in various human cancers. Underlying mechanisms, however, are still poorly understood...
  44. pmc Loss of Coxsackie and adenovirus receptor downregulates alpha-catenin expression
    K Stecker
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Charite Medical School, Campus Virchow, Augustenburgerplatz 1, Berlin 13353, Germany
    Br J Cancer 101:1574-9. 2009
    The Coxsackie and adenovirus receptor (CAR) has been shown to inhibit cancer cell proliferation, migration, and invasion. The underlying mechanisms, however, are poorly understood.
  45. pmc Isoform-specific regulation and localization of the coxsackie and adenovirus receptor in human airway epithelia
    Katherine J D A Excoffon
    Department of Biological Sciences, Wright State University, Dayton, Ohio, United States of America
    PLoS ONE 5:e9909. 2010
    ..Adenovirus fiber from most serotypes co-opts the Coxsackie-Adenovirus Receptor (CAR) to bind and enter cells...
  46. pmc The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K
    Petra Verdino
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 329:1210-4. 2010
    Coxsackie and adenovirus receptor (CAR) is the primary cellular receptor for group B coxsackieviruses and most adenovirus serotypes and plays a crucial role in adenoviral gene therapy...
  47. doi Novel splice variant CAR 4/6 of the coxsackie adenovirus receptor is differentially expressed in cervical carcinogenesis
    Marit Dietel
    Department of Gynaecology and Obstetrics, Jena University Hospital, Germany
    J Mol Med (Berl) 89:621-30. 2011
    The coxsackie adenovirus receptor (CAR) is a component of the tight junction complex and involved in cell adhesion...
  48. pmc Impact of the coxsackievirus and adenovirus receptor on the adenoma-carcinoma sequence of colon cancer
    K Stecker
    Department of Internal Medicine, Divisions of Gastroenterology and Hepatology, Charite Medical School, Campus Virchow, Augustenburgerplatz 1, Berlin 13353, Germany
    Br J Cancer 104:1426-33. 2011
    Coxsackie and adenovirus receptor (CAR) has been suggested to function as a tumour suppressor. Its impact on the adenoma-carcinoma sequence of the colon, however, is unclear.
  49. pmc ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor
    Markus D Lacher
    Department of Medicine, Division of Gastroenterology, University of California, San Francisco, CA, USA
    Mol Cancer 10:91. 2011
    ..2006 Feb 1;66(3):1648-57) signaling negatively regulate coxsackie virus and adenovirus receptor (CAR) cell-surface expression and adenovirus uptake...
  50. pmc CAR modulates E-cadherin dynamics in the presence of adenovirus type 5
    Fawziyah Hussain
    Division of Asthma, Allergy and Lung Biology, King s College London, London, United Kingdom
    PLoS ONE 6:e23056. 2011
    Adenovirus (Ad) serotype 5 (Ad5) fiber competitively binds to the coxsackievirus and Ad receptor (CAR) to attach Ad5 to target cells and also disrupts cell junctions and facilitates virus escape at a late stage in Ad5 infection...
  51. doi Expression of the coxsackie and adenovirus receptor in human lung cancers
    Zhaoli Chen
    Department of Health and Environment, Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No 1, Dali Road, Tianjin, 300050, People s Republic of China
    Tumour Biol 34:17-24. 2013
    The aim of this study is to elucidate the relation between expression of coxsackie and adenovirus receptor (CAR) and formation of lung cancer...
  52. ncbi Back pain in a large Canadian police force
    J J Brown
    Department of Medicine, University of Ottawa, Ontario, Canada
    Spine (Phila Pa 1976) 23:821-7. 1998
    ..back pain among Royal Canadian Mounted Police members and to assess the validity of the perception that the patrol car seat and the duty belt are causing a higher rate of low back pain among members of the Royal Canadian Mounted ..
  53. pmc Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
    W Xie
    Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Genes Dev 14:3014-23. 2000
    ..and genetically to activate CYP3A genes, while similar studies have established constitutive androstane receptor (CAR) as a CYP2B regulator...
  54. ncbi [Significance of a screening questionnaire for diagnosis of sleep apnea]
    T Ploch
    Medizinische Poliklinik, Zeitreihenlabor, , Marburg
    Pneumologie 47:108-11. 1993
    ..pills, hypertension, snoring, involuntary falling asleep, respiratory standstills, tendency to fall asleep during car driving and accidents in which the tendency to fall asleep was also involved...
  55. pmc In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists
    A D Medhurst
    Department of Neurosciences Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex
    Br J Pharmacol 122:469-76. 1997
    ..4, slope=1.8+/-0.3, n=4). SB 222200 ((-)-(S)-N-(alpha-ethylbenzyl)-3-methyl-2-phenylquinoline-4-car box amide; 30-300 nM, pA2=7.9, slope=1.4+/-0...
  56. ncbi Psychosocial job factors, physical workload, and incidence of work-related spinal injury: a 5-year prospective study of urban transit operators
    N Krause
    Division of Epidemiology, School of Public Health, University of California, Berkeley, USA
    Spine (Phila Pa 1976) 23:2507-16. 1998
    ..7-fold reduced risk for spinal injury (OR, 0.37; 95% CI, 0.15-0.93). Cable car crews performing the heaviest physical labor had a threefold increased risk of spinal injury compared with bus ..
  57. ncbi We are chronically sleep deprived
    M H Bonnet
    Dayton Veterans Affairs Medical Center, Wright State University, Ohio, USA
    Sleep 18:908-11. 1995
    ..surprising that fatigue is a factor in 57% of accidents leading to the death of a truck driver and in 10% of fatal car accidents and results in costs of up to 56 billion dollars per year...
  58. ncbi The long-range prognosis of arachnoiditis
    D W Guyer
    Vancouver Orthopaedic Group, Washington
    Spine (Phila Pa 1976) 14:1332-41. 1989
    ..Although the majority were able to walk and drive a car without limitation, ability to return to previous full-time occupations was markedly limited...
  59. ncbi Validity of patient reporting and predictive value of industrial physical work demands
    I Lindström
    Department of Orthopaedics, University of Goteborg, Sahlgren Hospital, Sweden
    Spine (Phila Pa 1976) 19:888-93. 1994
    This prospective study analyzed industrial physical work demands. The patients (n = 103), sick-listed 8 weeks because of low back pain, were industrial blue-collar workers in the car manufacturing industry.
  60. ncbi High-dose methylprednisolone prevents extensive sick leave after whiplash injury. A prospective, randomized, double-blind study
    K Pettersson
    Department of Orthopaedics, , Sweden
    Spine (Phila Pa 1976) 23:984-9. 1998
    ..This procedure was also adopted in a randomized study of cases of whiplash injury in car accidents...
  61. pmc Hydroxycinnamate (hca) catabolic genes from Acinetobacter sp. strain ADP1 are repressed by HcaR and are induced by hydroxycinnamoyl-coenzyme A thioesters
    Donna Parke
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    Appl Environ Microbiol 69:5398-409. 2003
    ..Sequence analysis of the newly cloned DNA identified five open reading frames designated hcaA, hcaB, hcaK, hcaR, and ORF1...
  62. ncbi Evaluation "in-car" countermeasures to sleepiness: cold air and radio
    L A Reyner
    Sleep Research Laboratory, Loughborough University, UK
    Sleep 21:46-50. 1998
    The efficacy of putative "in-car" countermeasures to driver sleepiness is unknown...
  63. ncbi A patient-reported comparison of trapeziectomy with Swanson Silastic implant or sling ligament reconstruction
    M E Lovell
    Centre for Upper Limb Surgery, Wrightington Hospital, Appley Bridge, UK
    J Hand Surg Br 24:453-5. 1999
    ..significantly better results were obtained for pain at 1 year, carrying a milk bottle and taking a handbrake off a car, and overall function...
  64. ncbi Profiling histidine-containing dipeptides in rat tissues by liquid chromatography/electrospray ionization tandem mass spectrometry
    Giancarlo Aldini
    Istituto Chimico Farmaceutico Tossicologico, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
    J Mass Spectrom 39:1417-28. 2004
    The histidine-containing dipeptides carnosine (CAR) and structurally related anserine (ANS) and homocarnosine (HCAR), widely distributed in vertebrate organisms, have recently been proposed as endogenous quenchers for highly cytotoxic ..
  65. pmc Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1)
    Xinrong Chen
    Department of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Toxicology 231:224-33. 2007
    ..Nuclear receptor co-transfection results indicated that human constitutive androstane receptor (hCAR) and human retinoid X receptor alpha (hRXRalpha) were involved in the transcriptional regulation of hSULT2A1...
  66. ncbi Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor
    Kaoru Kobayashi
    Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba 260 8675, Japan
    Drug Metab Dispos 33:924-9. 2005
    ..is a potent mouse CAR ligand that has been used to study CAR target genes in mice but does not activate human CAR (hCAR) or rat CAR (rCAR)...
  67. ncbi hCAR-EGFP fusion receptor in human follicular lymphoma B cells - a model for adenoviral gene therapy for B cell malignancies
    Mikko Mättö
    Department of Clinical Microbiology, University of Kuopio, Finland
    Int J Mol Med 17:1057-62. 2006
    ..More importantly, most tumor cells derived from B cell lineage express a very low level of the adenovirus receptor hCAR; thus, warranting the design of adenoviral vectors with high affinity to abundant B cell surface molecules...
  68. ncbi Asbestos exposure, physical activity and colon cancer: a case-control study
    P Vineis
    Dipartimento di Scienze Biomediche e Oncologia Umana, Main Hospital and University of Torino, Italy
    Tumori 79:301-3. 1993
    AIMS AND BACKGROUND: An association between colon cancer and the occupation of model or pattern maker in the car industry has been repeatedly suggested...
  69. ncbi Mectizan delivery systems and cost recovery in the Central African Republic
    A D Hopkins
    , Bangui, Central African Republic
    Ann Trop Med Parasitol 92:S97-100. 1998
    The Central African Republic (CAR) has a serious onchocerciasis problem. The disease is endemic in three quarters of the country and there is considerable onchocercal blindness in the north-west...
  70. ncbi Ca(2+)-evoked serotonin secretion by parafollicular cells: roles in signal transduction of phosphatidylinositol 3'-kinase, and the gamma and zeta isoforms of protein kinase C
    K Liu
    Division of Neuroscience, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 20:1365-73. 2000
    Parafollicular (PF) cells secrete 5-HT in response to stimulation of a G-protein-coupled Ca(2+) receptor (CaR) by increased extracellular Ca(2+) (upward arrow[Ca(2+)](e))...
  71. ncbi The HcaR regulatory protein of Photorhabdus luminescens affects the production of proteins involved in oxidative stress and toxemia
    Sabina Chalabaev
    Unite de Genetique des Genomes Bacteriens URA2171, Institut Pasteur, Paris, France
    Proteomics 7:4499-510. 2007
    Comparison of the proteomes of wild-type Photorhabdus luminescens and its hcaR derivative, grown in insect hemolymph, showed that hcaR disruption decreased the production of toxins (tcdA1, mcf, and pirAB) and proteins involved in ..
  72. doi Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region
    Kouichi Yoshinari
    Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aramaki aoba, Aoba ku, Sendai, Miyagi 980 8578, Japan
    Biochem Pharmacol 79:261-9. 2010
    ..In this system, human CAR (hCAR) enhanced the transcription of both genes through common promoter regions from -461 to -554 and from -18089 to -..
  73. ncbi Family history of hypertension and left ventricular mass in youth: possible mediating parameters
    B B Cook
    Department of Pediatrics, Medical College of Georgia, Augusta, USA
    Am J Hypertens 14:351-6. 2001
    ..Hemodynamics were measured at rest and during four stressors (ie, postural change, car driving simulation, video game, forehead cold)...
  74. ncbi Gene expression networks underlying retinoic acid-induced differentiation of human retinoblastoma cells
    Aimin Li
    Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, and Department of Cell and Neurobiology, The Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 9112, USA
    Invest Ophthalmol Vis Sci 44:996-1007. 2003
    ..To understand the genetic regulatory pathways underlying the retinoic acid (RA) induction of cone arrestin, gene array technology and other molecular tools were used to profile global gene expression changes in human retinoblastoma cells...
  75. ncbi CNTF induces dose-dependent alterations in retinal morphology in normal and rcd-1 canine retina
    Caroline J Zeiss
    Section of Comparative Medicine, Yale University School of Medicine, 375 Congress Ave, New Haven, CT 06510, USA
    Exp Eye Res 82:395-404. 2006
    ..Immunohistochemistry was performed on a subset of 11 dogs for expression of rhodopsin, human cone arrestin (hCAR) and recoverin...
  76. pmc Secretion and organization of a cornea-like tissue in vitro by stem cells from human corneal stroma
    Yiqin Du
    Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2588, USA
    Invest Ophthalmol Vis Sci 48:5038-45. 2007
    ..To investigate the potential of human corneal stromal stem cells to assume a keratocyte phenotype and to organize extracellular matrix (ECM) in vitro similar to corneal stromal tissue...
  77. ncbi Sick leave and disability pension among passenger car occupants injured in urban traffic
    P O Bylund
    , Department of Surgery, , Sweden
    Spine (Phila Pa 1976) 23:1023-8. 1998
    STUDY DESIGN: A follow-up cohort study of passenger car occupants injured in car crashes in an urban area in Sweden. OBJECTIVES: To analyze the injuries, injury events, and long-term consequences of injuries in car crashes...
  78. ncbi Alternative splicing within the ligand binding domain of the human constitutive androstane receptor
    Rajesh S Savkur
    Gene Regulation Research, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Mol Genet Metab 80:216-26. 2003
    The human constitutive androstane receptor (hCAR; NR1I3) is a member of the nuclear receptor superfamily. The activity of hCAR is regulated by a variety of xenobiotics including clotrimazole and acetaminophen metabolites...
  79. ncbi Mothers' experience with household roles and social support during the first postpartum year
    D K Gjerdingen
    Department of Family Practice and Community Health, University of Minnesota
    Women Health 21:57-74. 1994
    ..certain household chores (house cleaning, grocery shopping, cooking, washing clothes and dishes, household repairs, car maintenance, and garbage removal)...
  80. pmc Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transfer
    R J Pickles
    CF Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, 27599 7248, USA
    J Virol 74:6050-7. 2000
    ..The human coxsackievirus and adenovirus receptor (hCAR) was detected by immunofluorescence selectively at the basolateral surfaces of freshly ..
  81. ncbi [Traumatic tricuspid insufficiency. 5 cases]
    J M Quatre
    Service de cardiologie, , Paris
    Arch Mal Coeur Vaiss 81:325-30. 1988
    ..years) were followed up for 6 to 60 months for tricuspid valve regurgitation caused by a front-to-back injury (in a car in four cases, in an aircraft in one case)...
  82. ncbi Decreased width of the spinal canal in patients with chronic symptoms after whiplash injury
    K Pettersson
    Department of Orthopaedics, University Hospital of Northern Sweden, , Sweden
    Spine (Phila Pa 1976) 20:1664-7. 1995
    ..METHODS. Forty-eight consecutive patients were evaluated for whiplash trauma after car accidents...
  83. pmc Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12
    E Diaz
    Department of Molecular Microbiology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, 28006 Madrid, Spain
    J Bacteriol 180:2915-23. 1998
    ..two additional genes transcribed in the opposite direction that encode a potential permease (hcaT) and a regulator (hcaR)...
  84. pmc Methadone induces the expression of hepatic drug-metabolizing enzymes through the activation of pregnane X receptor and constitutive androstane receptor
    Antonia H Tolson
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, 20 Penn Street, Baltimore, MD 21201, USA
    Drug Metab Dispos 37:1887-94. 2009
    ..MD significantly increased human (h) PXR-mediated CYP2B6 reporter activities but exhibited minimal effect on hCAR activation as a result of the constitutive activity of hCAR in HepG2 cells...
  85. ncbi Coordinating cognitive information: task effects and individual differences in integrating information from several sources
    P L Yee
    University of Washington
    Cogn Psychol 23:615-80. 1991
    In many tasks people have to coordinate the information from several sources. An example would be driving a car while listening to directions. The driver has to establish a correspondence between a visual picture and verbal instructions...
  86. ncbi Haemodynamic changes in patients with whiplash injury measured by transcranial Doppler sonography (TCD)
    V Seric
    Department of Neurology, Sestre Milosrdnice University Hospital, Zagreb, Croatia
    Coll Antropol 24:197-204. 2000
    ..of vertebrobasilar circulation in patients with a whiplash injury of the cervical spine, that occurred mostly in car accident...
  87. doi Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent
    Katalin Monostory
    Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Drug Metab Dispos 37:375-85. 2009
    ..Rosuvastatin was found to increase human constitutive androstane receptor (hCAR)-mediated transcription of CYP3A4, CYP2C9, and CYP2B6 genes, predicting the consequent potential for drug ..
  88. pmc Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction
    Connie R Bezzina
    Department of Experimental Cardiology, University of Amsterdam, Amsterdam, The Netherlands
    Nat Genet 42:688-91. 2010
    ..This locus has not previously been implicated in arrhythmia susceptibility...
  89. ncbi 2,4-Dinitro-3,5,6-trideuterophenylhydrazones for the quantitation of aldehydes and ketones in air samples by liquid chromatography-mass spectrometry
    G Zurek
    , Anorganisch-Chemisches Institut, Abteilung Analytische Chemie, Germany
    J Chromatogr A 869:251-9. 2000
    ..of a series of aldehydes and ketones are applied as internal standards for the determination of the carbonyls in car exhaust samples. Various aldehydes are identified and quantified by MS detection...
  90. ncbi The interaction between technical requirements and comfort in care seating
    E Fubini
    Department of Animal Biology, University of Torino, Italy
    Coll Antropol 21:405-27. 1997
    The paper analyses different ergonomic aspects that it is necessary to take into account to design car seats tat can fit users' requirements in terms of safety and comfort, two aspects that are closely related...
  91. ncbi Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR
    H S Choi
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 272:23565-71. 1997
    ..termed mCAR, that is closely related to the previously described human orphan MB67, referred to here as hCAR. Like hCAR, mCAR expression is highest in liver...
  92. ncbi Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms
    Jean Marc Pascussi
    INSERM, U632, Montpellier, France
    Hepatology 45:1146-53. 2007
    ..In this work, we analyzed the expression of human CAR (hCAR) in normal liver during development and in hepatocellular carcinoma (HCC) and investigated the effect of hepatocyte ..
  93. doi Characterization of the porcine constitutive androstane receptor (CAR) and its splice variants
    M A Gray
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
    Xenobiotica 39:915-30. 2009
    ..androstane receptor (CAR; NR1I3) was cloned and compared for homology and activity with mouse and human CAR (mCAR, hCAR). Porcine CAR (pgCAR) was 86% and 75% homologous to hCAR at the nucleotide and protein levels...
  94. ncbi Determination of benzene, toluene, ethylbenzene and xylenes in indoor air at environmental levels using diffusive samplers in combination with headspace solid-phase microextraction and high-resolution gas chromatography-flame ionization detection
    K Elke
    , Department of Analytical Chemistry, , Germany
    J Chromatogr A 826:191-200. 1998
    ..Applications such as the determination of BTEXs in indoor air inside buildings, inside a train and a car are presented, indicating the usefulness of the described procedure for short-term measurements of environmental ..
  95. ncbi Chiral beta-cyclodextrin-based polymer supports prepared via ring-opening metathesis graft-polymerization
    B Mayr
    Institute of Analytical Chemistry and Radiochemistry, University of Innsbruck, Austria
    J Chromatogr A 907:47-56. 2001
    ..1), tetrakis(6-O-norborn-2-ene-5-carboxyl)-beta-CD (2), (3), 6-O-(6-norborn-2-ene-5-car-6-O-(7-oxanorborn-2-ene-5-carboxyl)-beta-CD bonylaminohexoyl)-beta-CD (4), 6-O-(norborn-2-ene-5-..
  96. ncbi Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes
    Hongbing Wang
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Drug Metab Dispos 31:620-30. 2003
    ..In hGR and human constitutive androstane receptor (hCAR) cotransfection assays, activated hGR increased the constitutive activation of PBREM reporter constructs by hCAR in ..
  97. ncbi Amino acids important for ligand specificity of the human constitutive androstane receptor
    Johanna Jyrkkärinne
    Department of Pharmaceutics, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    J Biol Chem 280:5960-71. 2005
    The human constitutive androstane receptor (CAR, NR1I3) is an important ligand-activated regulator of oxidative and conjugative enzymes and transport proteins...
  98. ncbi Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors
    M Everts
    Division of Human Gene Therapy, Department of Medicine, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Gene Ther 12:1042-8. 2005
    ..Therefore, we have exploited mice transgenic for the human coxsackie and adenovirus receptor (hCAR) to establish a new model for transient expression of human tumor-associated antigens in the pulmonary vasculature...
  99. doi Cigarette smoke extract induces CYP2B6 through constitutive androstane receptor in hepatocytes
    Ikumi Washio
    Department of Clinical Pharmacology and Pharmacogenomics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Drug Metab Dispos 39:1-3. 2011
    ..preparing cigarette smoke extract (CSE), we addressed the possibility that human constitutive androstane receptor (hCAR) is involved in smoking-mediated induction of CYP2B6...
  100. pmc Oncolytic Adenovirus: Strategies and Insights for Vector Design and Immuno-Oncolytic Applications
    Hanni Uusi-Kerttula
    Institute of Cancer and Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Viruses 7:6009-42. 2015
    ..Active tumor targeting is also hampered by the ubiquitous nature of the Ad5 receptor, hCAR, as well as the lack of highly tumor-selective targeting ligands and suitable targeting strategies...
  101. doi Membrane Dynamics and Signaling of the Coxsackievirus and Adenovirus Receptor
    Fabien Loustalot
    Institut de Genetique Moleculaire de Montpellier, Universite de Montpellier, Montpellier, France
    Int Rev Cell Mol Biol 322:331-62. 2016
    The coxsackievirus and adenovirus receptor (CAR) belongs to the immunoglobulin superfamily and acts as a receptor for some adenovirus types and group B coxsackieviruses...

Research Grants9

  1. Expression of the coxsackievirus and adenovirus receptor
    Christopher Cohen; Fiscal Year: 2002
    ..Group B coxsackieviruses and many adenoviruses initiate infection by binding to the coxsackievirus and adenovirus receptor (CAR)...
  2. Hongbing Wang; Fiscal Year: 2016
    ..Towards this end, we have shown that activation of the human constitutive androstane receptor (hCAR) preferentially induced the expression of hepatic CYP2B6 over CYP3A4 and increased the formation of 4-OH-CPA...
  3. Metallothionein & Cadmium Carcinogenesis in the Prostate
    Shuk Mei Ho; Fiscal Year: 2006
    ..Part-2 By cross-breeding with a mouse, named CAR, which expresses membrane Coxsackie/human Adenovirus Receptors (hCAR) on all body cells, with PBMT-1 we will generated the CAR/PBMT-1 mouse...
  4. MYOCARDITIS--RECEPTORS FOR A CARDIOTROPIC VIRUS
    Jeffrey Bergelson; Fiscal Year: 2001
    ..We have now purified and cloned another- --novel---cell surface protein, CAR, that functions both in attachment and infection by all six coxsackie B serotypes...
  5. Naturalization-Resistant Adenovirus Vaccine Vector
    Jeffrey Bergelson; Fiscal Year: 2005
    ..Such a chimeric vector could solve one of the major obstacles to the use of adenovirus vectors for HIV immunization. ..
  6. Junction Adhesion Molecule CAR and the Immune System
    Steven Carson; Fiscal Year: 2007
    b>CAR is a junction adhesion molecule (JAM), similar to other known JAM proteins. These proteins generally localize to tight junctions, where they participate in cell-cell adhesion and link to cytoplasmic proteins...
  7. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2007
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  8. Cell Biology of Enterovirus Infection in Polarized Epithelial Cells
    Jeffrey Bergelson; Fiscal Year: 2007
    ..leads to actin rearangements and virus movement to the tight junction, where interaction with the coxsackievirus and adenovirus receptor (CAR) initiates the uncoating process that releases viral RNA; activation of Fyn kinase triggers ..
  9. Mechanisms of Cone Pigment Deactivation
    Cheryl Craft; Fiscal Year: 2009
    ..pathway and to accomplish our goals, experiments are designed to explore the function(s) of cone arrestin (CAR), its targeted G protein-coupled receptors (S and M opsin pigments) and other potential relevant partners in the ..