CAPZA1

Summary

Gene Symbol: CAPZA1
Description: capping actin protein of muscle Z-line alpha subunit 1
Alias: CAPPA1, CAPZ, CAZ1, F-actin-capping protein subunit alpha-1, Cap Z, capZ alpha-1, capping protein (actin filament) muscle Z-line, alpha 1
Species: human

Top Publications

  1. ncbi Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families
    E A Barron-Casella
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 270:21472-9. 1995
  2. ncbi Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes
    M C Hart
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Genomics 39:264-70. 1997
  3. pmc Protein-lipid interactions: correlation of a predictive algorithm for lipid-binding sites with three-dimensional structural data
    David L Scott
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program and the Massachusetts General Hospital Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Theor Biol Med Model 3:17. 2006
  4. pmc WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes
    Da Jia
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:10442-7. 2010
  5. ncbi Regulation of actin filament length in erythrocytes and striated muscle
    V M Fowler
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 8:86-96. 1996
  6. pmc Isolation and characterization of cDNA encoding the alpha subunit of Cap Z(36/32), an actin-capping protein from the Z line of skeletal muscle
    J F Casella
    Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 86:5800-4. 1989
  7. ncbi Unique S100 target protein interactions
    Atoosa Rezvanpour
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Gen Physiol Biophys 28:F39-46. 2009
  8. pmc Transportation of nanoscale cargoes by myosin propelled actin filaments
    Malin Persson
    School of Natural Sciences, Linnaeus University, Kalmar, Sweden
    PLoS ONE 8:e55931. 2013
  9. doi The effect of Rho-associated kinase inhibition on the proteome pattern of dissociated human embryonic stem cells
    Javad Gharechahi
    Department of Molecular Systems Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
    Mol Biosyst 10:640-52. 2014
  10. pmc Proteomic analysis of laser capture microscopy purified myotendinous junction regions from muscle sections
    Tugba Can
    Department of Biology, University of York, Wentworth Way, York YO10 5DD, UK
    Proteome Sci 12:25. 2014

Research Grants

  1. R John Solaro; Fiscal Year: 2016
  2. CapZ, PKC Signaling and Control of Sarcomere Function
    C Sumandea; Fiscal Year: 2006
  3. Gordon Research Conference on Motile and Contractile Sys
    Velia Fowler; Fiscal Year: 2003
  4. CAPPING ACTIN GROWTH IN ERYTHROID NONERYTHROID CELLS
    Velia Fowler; Fiscal Year: 2004
  5. INTEGRATION OF ACTIN BEADED FILAMENT SYSTEM IN THE LENS
    Velia Fowler; Fiscal Year: 2003

Scientific Experts

Detail Information

Publications138 found, 100 shown here

  1. ncbi Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families
    E A Barron-Casella
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 270:21472-9. 1995
    ..human retinal cDNA library, we have isolated cDNAs that are homologs for the alpha 2 and beta subunits of chicken Cap Z. The derived human alpha subunit shares 95% amino acid identity with the chicken alpha 2 subunit; the beta subunit ..
  2. ncbi Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes
    M C Hart
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Genomics 39:264-70. 1997
    ..Their chromosomal locations were identified by interspecies backcross mapping. The alpha 1 gene (Cappa1) mapped to chromosome 3 between D3Mit11 and D3Mit13...
  3. pmc Protein-lipid interactions: correlation of a predictive algorithm for lipid-binding sites with three-dimensional structural data
    David L Scott
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program and the Massachusetts General Hospital Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Theor Biol Med Model 3:17. 2006
    ..It is unclear whether these protein-lipid-interactions are dependent on shared protein motifs or unique regional physiochemistry, or are due to more global characteristics of the protein...
  4. pmc WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes
    Da Jia
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:10442-7. 2010
    ..FAM21 interacts directly with CAPZ and inhibits its actin-capping activity...
  5. ncbi Regulation of actin filament length in erythrocytes and striated muscle
    V M Fowler
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 8:86-96. 1996
    ..Tropomodulin caps the slow-growing, pointed filament ends in muscle and in erythrocytes. CapZ caps the fast-growing, barbed filament ends in striated muscle, whereas a newly discovered barbed end capping ..
  6. pmc Isolation and characterization of cDNA encoding the alpha subunit of Cap Z(36/32), an actin-capping protein from the Z line of skeletal muscle
    J F Casella
    Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 86:5800-4. 1989
    cDNA encoding the alpha chain of Cap Z has been isolated by screening a lambda gt11 library with affinity-purified antibodies...
  7. ncbi Unique S100 target protein interactions
    Atoosa Rezvanpour
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Gen Physiol Biophys 28:F39-46. 2009
    ..The structures of some S100 proteins in the presence of peptide targets from Ndr kinase, p53, CapZ, annexins A1 and A2 and the Siah-1 Interacting Protein indicate there are at least three modes of recognition that ..
  8. pmc Transportation of nanoscale cargoes by myosin propelled actin filaments
    Malin Persson
    School of Natural Sciences, Linnaeus University, Kalmar, Sweden
    PLoS ONE 8:e55931. 2013
    ..along the actin filaments ("side-attached") or to the trailing filament end via the plus end capping protein CapZ. Long-distance transportation (>100 µm) could be seen for all cargoes independently of attachment mode but the ..
  9. doi The effect of Rho-associated kinase inhibition on the proteome pattern of dissociated human embryonic stem cells
    Javad Gharechahi
    Department of Molecular Systems Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
    Mol Biosyst 10:640-52. 2014
    ..showed that ROCKi induced upregulation of some actin binding proteins such as tropomyosin, F-actin capping protein (CapZ) and transgelin and downregulation of tubulin...
  10. pmc Proteomic analysis of laser capture microscopy purified myotendinous junction regions from muscle sections
    Tugba Can
    Department of Biology, University of York, Wentworth Way, York YO10 5DD, UK
    Proteome Sci 12:25. 2014
    ..g., actinins, capZ, αB cristallin, filamin C, cypher, calsarcin, desmin, FHL1, telethonin, nebulin, titin and an enigma-like protein) ..
  11. pmc Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor
    Ruijun Tian
    Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5 Department of Chemistry and Shenzhen Key Laboratory of Cell Microenvironment, South University of Science and Technology of China, Shenzhen 518055, China
    Proc Natl Acad Sci U S A 112:E1594-603. 2015
    ..Among the cellular phosphoproteins influenced by CD28 signaling, CapZ-interacting protein (CapZIP), a regulator of the actin cytoskeleton, was implicated by functional studies...
  12. pmc Structural insights into the binding of the human receptor for advanced glycation end products (RAGE) by S100B, as revealed by an S100B-RAGE-derived peptide complex
    Jaime L Jensen
    Department of Chemistry and Biochemistry, North Dakota State University, PO Box 6050, Fargo, ND 58108 6050, USA
    Acta Crystallogr D Biol Crystallogr 71:1176-83. 2015
    ..binding interface of this peptide is compared with that found in the complex between S100B and the 12-amino-acid CapZ-derived peptide TRTK-12...
  13. pmc The Proteomic Analysis of Human Placenta with Pre-eclampsia and Normal Pregnancy
    Jeong In Yang
    Department of Obstetrics and Gynecology, Ajou University Medical School, Suwon, Korea
    J Korean Med Sci 30:770-8. 2015
    ....
  14. pmc Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2
    Ruth Rollason
    Academic Renal Unit, School of Clinical Sciences, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, U K
    Biosci Rep 36:e00302. 2016
    ..purification coupled with MS we demonstrate that INF2 interacts with profilin 2 and the F-actin capping protein, CapZ α-1. These interactions are increased by the presence of the disease causing mutations...
  15. pmc Variation in stiffness regulates cardiac myocyte hypertrophy via signaling pathways
    Jieli Li
    a Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, 835 S Wolcott Ave, Chicago, IL 60612, USA
    Can J Physiol Pharmacol . 2016
    ..Actin assembly involves the actin capping protein Z (CapZ)...
  16. pmc Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family
    O Turunen
    Haartman Institute, Department of Virology, Helsinki University, Finland
    J Cell Biol 126:1445-53. 1994
    ..sequence homology to the actin-binding site in the COOH terminus of the beta subunit of the actin-capping protein CapZ and one of the potential actin-binding sites in myosin heavy chain...
  17. ncbi High concentrations of phosphatidylinositol-4,5-bisphosphate may promote actin filament growth by three potential mechanisms: inhibiting capping by neutrophil lysates, severing actin filaments and removing capping protein-beta2 from barbed ends
    M J DiNubile
    Department of Medicine, Cooper Hospital University Medical Center, UMDNJ Robert Wood Johnson Medical School, Camden, NJ, USA
    Biochim Biophys Acta 1358:261-78. 1997
    ..lysates which we had previously demonstrated to be almost entirely due to capping protein-beta2, a homologue of cap Z. High concentrations of PIP2 totally prevented the capping of exogenous spectrin-F-actin seeds by dilute ..
  18. ncbi Depolymerization of actin filaments by profilin. Effects of profilin on capping protein function
    Michael R Bubb
    The Research Service, Malcom Randall Department of Veterans Affairs Medical Center, Gainesville, Florida 32608, USA
    J Biol Chem 278:24629-35. 2003
    ..In contrast, neither gelsolin nor CapZ could be dissociated from actin filaments under the same conditions...
  19. ncbi Tuberous sclerosis genes regulate cellular 14-3-3 protein levels
    Markus Hengstschlager
    Obstetrics and Gynecology, University of Vienna, Prenatal Diagnosis and Therapy, Wahringer Gurtel 18 20, Vienna A 1090, Austria
    Biochem Biophys Res Commun 312:676-83. 2003
    ..In the same experiments the protein levels of keratin 7, capZ alpha-1 subunit, ezrin, and nedasin were not affected by ectopic TSC1 or TSC2...
  20. pmc Three-dimensional reconstruction of the dynactin complex by single-particle image analysis
    J L Hodgkinson
    Department of Biomedical Sciences, Imperial College London, London SW3 6LY, United Kingdom
    Proc Natl Acad Sci U S A 102:3667-72. 2005
    ..Additional mass, not part of the Arp backbone, was also seen. A preliminary fitting of the capping protein CapZ structure into our 3D reconstruction of the dynactin complex suggests that it is optimally placed to perform its ..
  21. ncbi S100A8 is identified as a biomarker of HPV18-infected oral squamous cell carcinomas by suppression subtraction hybridization, clinical proteomics analysis, and immunohistochemistry staining
    Wan Yu Lo
    Department of Medical Research, China Medical University Hospital Taichung, Taiwan
    J Proteome Res 6:2143-51. 2007
    ..indicated that there was over 10-fold overexpression of Stratifin, F-actin capping protein alpha-1 subunit (CapZ alpha-1), Apolipoprotein A-1 (ApoA-1), Heat-shock protein 27 (HSP27), Arginase-1, p16INK4A, and S100 calcium-..
  22. doi Cardiac myofilament regulation by protein phosphatase type 1alpha and CapZ
    Fenghua Yang
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    Biochem Cell Biol 86:70-8. 2008
    ..The Z-disc protein CapZ controls protein kinase C (PKC) regulation of cardiac myofilaments, but whether this effect is specific to PKC, or ..
  23. pmc Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection
    Jeremy Juang
    The Department of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 207:1223-34. 2010
    ..We show that the affinity of the OT-I TCR for its endogenous positively selecting ligands, Catnb-H-2Kb and Cappa1-H-2Kb, is significantly lower than for previously reported positively selecting altered peptide ligands...
  24. pmc Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
    Norihiro Kato
    Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
    Nat Genet 43:531-8. 2011
    ..significant (P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3...
  25. pmc Treponema denticola major outer sheath protein induces actin assembly at free barbed ends by a PIP2-dependent uncapping mechanism in fibroblasts
    Michelle B Visser
    Matrix Dynamics Group, Dental Research Institute, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 6:e23736. 2011
    ..Immunoblotting experiments showed that gelsolin and CapZ were released from actin filaments, whereas cofilin remained in an inactive state...
  26. pmc Dynactin integrity depends upon direct binding of dynamitin to Arp1
    Frances Ka Yan Cheong
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218
    Mol Biol Cell 25:2171-80. 2014
    ..dynamitin, p150, and p24 from dynactin, leaving behind Arp1 filaments carrying the remaining dynactin subunits (CapZ, p62, Arp11, p27, and p25)...
  27. pmc Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension
    Xiangfeng Lu
    State Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
    Hum Mol Genet 24:865-74. 2015
    ..81 × 10(-3) to 5.16 × 10(-8). These findings provide new mechanistic insights into the regulation of blood pressure and potential targets for treatments...
  28. doi CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane
    Na Mi
    The State Key Laboratory of Membrane Biology, Tsinghua University Peking University Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Nat Cell Biol 17:1112-23. 2015
    ..of actin puncta is disrupted by an actin polymerization inhibitor or by knocking down the actin-capping protein CapZβ, isolation membranes and omegasomes collapse into mixed-membrane bundles...
  29. pmc Preliminary Proteomic Analysis of A549 Cells Infected with Avian Influenza Virus H7N9 and Influenza A Virus H1N1
    Xiaoman Ding
    School of Public Health, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 11:e0156017. 2016
    ..05) at 24, 48 and 72hpi, especially F-actin-capping protein subunit alpha-1 (CAPZA1), Ornithine aminotransferase (OAT), Poly(rC)-binding protein 1 (PCBP1), Eukaryotic translation initiation factor ..
  30. ncbi Beta-actinin is equivalent to Cap Z protein
    K Maruyama
    Department of Molecular Biology, Psychiatric Research Institute of Tokyo, Japan
    J Biol Chem 265:8712-5. 1990
    ..peptides of beta I were nearly identical with those of portions of the muscle barbed end-blocking protein Cap Z alpha, although several amino acids were different from those deduced from cDNA sequences (Casella, J.F...
  31. ncbi Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach
    V David
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Sci 111:2877-84. 1998
    ..In addition, three proteins not previously known to be associated with Listeria tails, coronin, Rac and capZ, were identified in our affinity approach...
  32. ncbi Generation of functional beta-actinin (CapZ) in an E. coli expression system
    Y Soeno
    Department of Biology, Faculty of Science, Chiba University, Japan
    J Muscle Res Cell Motil 19:639-46. 1998
    beta-actinin (CapZ) is a heterodimeric actin-binding protein which caps the barbed end of action filaments and nucleates actin-polymerization in a Ca2+ -independent manner. In myofibrils it is localized in the Z-lines...
  33. ncbi Modifications of trout (Oncorhynchus mykiss) muscle proteins by preslaughter activity
    Martine Morzel
    Quality of Animal Products, INRA, 63122 St Genes Champanelle, France
    J Agric Food Chem 54:2997-3001. 2006
    ..Persistent under-representation of desmin, a key cytoskeletal protein, in fish submitted to intense muscular activity suggests that such a preslaughter treatment can have an effect on post-mortem muscle integrity...
  34. pmc Tropomyosin modulates erythrocyte membrane stability
    Xiuli An
    Red Cell Physiology Laboratory, New York Blood Center, New York, NY 10021, USA
    Blood 109:1284-8. 2007
    ..9, tropomodulin, and a small proportion of capZ, the functions of which are poorly defined...
  35. pmc CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl
    Musheng Bao
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 189:786-92. 2012
    ..Therefore, CD2AP positively regulates BDCA2/FcεR1γ signaling by forming a complex with SHIP1 to inhibit the E3 ubiquitin ligase Cbl...
  36. pmc Prognostic value of CAPZA1 overexpression in gastric cancer
    Young Joon Lee
    Department of Surgery, Postgraduate School of Medicine, Gyeongnam Regional Cancer Center, Gyeongsang National University, Jinju, Republic of Korea
    Int J Oncol 42:1569-77. 2013
    F-actin capping protein α1 subunit (CAPZA1) was previously identified in a proteomic analysis of human gastric cancer clinical specimens and selected for further study...
  37. pmc Treponema denticola major outer sheath protein impairs the cellular phosphoinositide balance that regulates neutrophil chemotaxis
    Michelle B Visser
    Matrix Dynamics Group, Dental Research Institute, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e66209. 2013
    ..Release of the actin capping proteins gelsolin and CapZ in response to fMLP was also inhibited by Msp exposure...
  38. doi A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors
    Mariaceleste Aragona
    Department of Molecular Medicine, University of Padua School of Medicine, viale Colombo 3, 35131 Padua, Italy
    Cell 154:1047-59. 2013
    ..We identify the F-actin-capping/severing proteins Cofilin, CapZ, and Gelsolin as essential gatekeepers that limit YAP/TAZ activity in cells experiencing low mechanical stresses, ..
  39. pmc BAG3: a new player in the heart failure paradigm
    Tijana Knezevic
    Department of Neuroscience, Temple University School of Medicine, 3500 N Broad Street, Suite 1150, Philadelphia, PA, 19140, USA
    Heart Fail Rev 20:423-34. 2015
    ..apoptosis by interacting with Bcl2 and maintaining the structural integrity of the Z-disk in muscle by binding with CapZ. The importance of BAG3 in the homeostasis of myocytes and its role in the development of heart failure was ..
  40. pmc Single-molecule visualization of a formin-capping protein 'decision complex' at the actin filament barbed end
    Jeffrey P Bombardier
    Department of Biochemistry, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Nat Commun 6:8707. 2015
    ..Our observations suggest new molecular mechanisms for the control of actin filament length and for the capture of filament barbed ends in cells. ..
  41. pmc Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer
    Jong Hyun Lee
    College of Korean Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
    Oncotarget . 2016
    ..Here, we investigated whether capsazepine (Capz), a synthetic analogue of capsaicin, exerts anticancer effects by inhibiting STAT3 activation in prostate cancer ..
  42. pmc Regulation of sodium channel activity by capping of actin filaments
    Ekaterina V Shumilina
    Institute of Cytology Russian Academy of Sciences, St Petersburg 194064, Russia
    Mol Biol Cell 14:1709-16. 2003
    ..inside-out patch clamp experiments were performed to study the effect of the heterodimeric actin capping protein CapZ on sodium channel regulation in leukemia K562 cells...
  43. ncbi Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change
    Kurt L Barkalow
    Division of Hematology, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 285:C797-805. 2003
    ..inhibition blocks activation of Rac, but not of Cdc42, and diminishes the association of Arp2/3 complex and CapZ with polymerized actin...
  44. ncbi Arabidopsis capping protein (AtCP) is a heterodimer that regulates assembly at the barbed ends of actin filaments
    Shanjin Huang
    Department of Biological Sciences and Purdue Motility Group, Purdue University, West Lafayette, Indiana 47907 2064, USA
    J Biol Chem 278:44832-42. 2003
    ..042 pointed ends created per AtCP polypeptide compares favorably with mouse CapZ, which has a maximal nucleation of 0.17 pointed ends per CapZ polypeptide...
  45. ncbi Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration
    Matthias Krause
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Cell Dev Biol 19:541-64. 2003
    ..these proteins associate with barbed ends of actin filaments and antagonize filament capping by capping protein (CapZ)...
  46. ncbi F-actin capping (CapZ) and other contractile saphenous vein smooth muscle proteins are altered by hemodynamic stress: a proteonomic approach
    Emma McGregor
    Department of Vascular Surgery, Imperial College School of Medicine at Charing Cross Hospital, St Dunstan s Road, London W6 8RP, United Kingdom
    Mol Cell Proteomics 3:115-24. 2004
    ..018). The abundance of actin-capping protein alpha2 subunit CapZ had decreased 3-fold, p = 0.04. A 19-kDa proteolytic fragment of actin increased 2-fold, p = 0.04...
  47. ncbi Calcium transients regulate patterned actin assembly during myofibrillogenesis
    Hongyan Li
    Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA
    Dev Dyn 229:231-42. 2004
    ..Here, we show that blocking transients also compromises patterned assembly of actin thin filaments, titin, and capZ. Because a conserved temporal assembly pattern has been described for these proteins, selective inhibitors of ..
  48. ncbi The erythrocyte skeletons of beta-adducin deficient mice have altered levels of tropomyosin, tropomodulin and EcapZ
    Fabiola Porro
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012, Trieste, Italy
    FEBS Lett 576:36-40. 2004
    ..In fact, CapZ, the main muscle actin-capping protein of the barbed ends that in the erythrocytes is cytoplasmic, is 9-fold ..
  49. pmc Differential effects of Latrunculin-A on myofibrils in cultures of skeletal muscle cells: insights into mechanisms of myofibrillogenesis
    Jushuo Wang
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Cell Motil Cytoskeleton 62:35-47. 2005
    ..confer greater resistance to depolymerization by Lat-A, we stained the myotubes with an antibody directed against CapZ, a protein that blocks the release of monomer actin from the barbed ends of actin filaments...
  50. ncbi VR1-mediated depressor effects during high-salt intake: role of anandamide
    Youping Wang
    Department of Medicine and Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Hypertension 46:986-91. 2005
    ..during high-salt intake, which can be blocked by a selective vanilloid receptor 1(VR1) antagonist, capsazepine (CAPZ)...
  51. ncbi A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells
    Clark D Wells
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Cell 125:535-48. 2006
    ..We propose that Rich1 and Amot maintain TJ integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking...
  52. ncbi TRPV1-mediated diuresis and natriuresis induced by hypertonic saline perfusion of the renal pelvis
    Yi Zhu
    Department of Medicine, Michigan State University, East Lansing, Mich 48823, USA
    Am J Nephrol 27:530-7. 2007
    ..This study was designed to test the hypothesis that TRPV1 mediates diuresis and natriuresis induced by hypertonic saline perfusion into the pelvis...
  53. pmc Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-beta2 signaling
    Rudolf Fuchshofer
    Institute of Human Anatomy and Embryology, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    Exp Eye Res 88:1020-32. 2009
    ..Among the genes that were found to be regulated were CAPZA1, CDC42BPB, EFEMP1, FGF5, FSTL3, HBEGF, LTBP1, LTBP2, MATN2, NRP1, SERPINE1, SH3MD1, SMTN, SMAD7, TFPI2, TNFAIP6, ..
  54. doi Activity-dependent localization in spines of the F-actin capping protein CapZ screened in a rat model of dementia
    Takuma Kitanishi
    The University of Tokyo, Bunkyo ku, Japan
    Genes Cells 15:737-47. 2010
    ..and control sides of hippocampi after unilateral FFT revealed a reduction in the F-actin capping protein (CapZ) signal on the FFT side...
  55. doi Reduced cardiac CapZ protein protects hearts against acute ischemia-reperfusion injury and enhances preconditioning
    Feng Hua Yang
    Cardiovascular Research Group, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Mol Cell Cardiol 52:761-72. 2012
    The Z-disc protein CapZ has historically been classified as a structural element, anchoring sarcomeric actin...
  56. doi Identifying a role of the actin capping protein CapZ in β-adrenergic receptor signalling
    L Gaikis
    Cardiovascular Research Group, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada
    Acta Physiol (Oxf) 207:173-82. 2013
    ..Reductions in the cardiac Z-disc protein CapZ attenuate PKC regulation of myofilament activation...
  57. doi Tandem duplication of KIT exon 11 influences the proteome of canine mast cell tumours
    P Schlieben
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163, Berlin, Germany
    J Comp Pathol 148:318-22. 2013
    ..These are mainly involved in cytoskeleton structure and cell motility (ACTR2, ACTB and CAPPA1), cell signalling (ARHGDIA) and lipid metabolism (ALOX15 and ACSBG4), or are serum proteins...
  58. doi Actin capping proteins, CapZ (β-actinin) and tropomodulin in amphioxus striated muscle
    Yulong Bao
    Department of Biology, Graduate School of Science, Chiba University, Chiba 263 8522, Japan
    Gene 510:78-86. 2012
    b>CapZ (β-actinin) and tropomodulin (Tmod) are capping proteins involved in the maintenance of thin filaments in vertebrate skeletal muscles. In this study, we focused on amphioxus, the most primitive chordate...
  59. pmc CapZ and actin capping dynamics increase in myocytes after a bout of exercise and abates in hours after stimulation ends
    Ying Hsi Lin
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60612, USA
    J Appl Physiol (1985) 114:1603-9. 2013
    ..The goal of this work is to address how proteins of the thin filament (actin and its capping protein CapZ) are changed by 1 h of mechanical stimulation and return to baseline over time...
  60. pmc Organization of F-actin by Fesselin (avian smooth muscle synaptopodin 2)
    Mechthild M Schroeter
    Institute of Vegetative Physiology, University of Cologne, Robert Koch Strasse 39, D 50931 Cologne, Germany
    Biochemistry 52:4955-61. 2013
    ..Blockers of actin growth at the barbed end (cytochalasin D and CapZ) did not prevent fesselin from polymerizing actin...
  61. pmc Concurrent gene signatures for han chinese breast cancers
    Chi Cheng Huang
    Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei City, Taiwan Cathay General Hospital SiJhih, New, Taipei City, Taiwan School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan School of Medicine, Taipei Medical University, Taipei City, Taiwan
    PLoS ONE 8:e76421. 2013
    ..was built based on the first supervised principal component from 16 genes (RCAN3, MCOLN2, DENND2D, RWDD3, ZMYM6, CAPZA1, GPR18, WARS2, TRIM45, SCRN1, CSNK1E, HBXIP, CSDE1, MRPL20, IKZF1, and COL20A1), and distinct survival patterns ..
  62. pmc Identification and characterization of an actin-binding site of CapZ
    C Hug
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri
    J Cell Biol 116:923-31. 1992
    A mAb (1E5) that binds the COOH-terminal region of the beta subunit of chicken CapZ inhibits the ability of CapZ to bind the barbed ends of actin filaments and nucleate actin polymerization...
  63. pmc The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation
    F Buss
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QR, United Kingdom
    J Cell Biol 143:1535-45. 1998
    ..These results strongly support a role for myosin VI in membrane traffic on secretory and endocytic pathways...
  64. ncbi beta-Actinin, Cap Z, connectin and titin: what's in a name?
    Koscak Maruyama
    National Center for University Entrance Examinations, Meguro, Tokyo 153 8501, Japan
    Trends Biochem Sci 27:264-6. 2002
  65. ncbi Postmortem proteome changes of porcine muscle related to tenderness
    Rene Lametsch
    Department of Food Science, Danish Institute of Agricultural Sciences, Tjele, Denmark
    J Agric Food Chem 51:6992-7. 2003
    ..myofibril proteins or fragments included myosin heavy chain, titin, myosin light chain I, myosin light II, CapZ, and cofilin...
  66. doi Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35
    Michael E Harbour
    Cambridge Institute for Medical Research Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Cambridge CB2 0XY, UK
    Biochem J 442:209-20. 2012
    ..Additionally, overexpression of the Fam21-tail results in cell-spreading defects, implicating the activity of the WASH complex in regulating the mobilization of membrane into the endosome-to-cell surface pathway...
  67. doi Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did Not
    Annett Linge
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Ireland
    Invest Ophthalmol Vis Sci 53:4634-43. 2012
    ..To compare the proteomic profiles of two categories of primary uveal melanoma tissue samples; those from patients who have subsequently developed metastatic disease and those who have not...
  68. pmc Conservation and divergence between cytoplasmic and muscle-specific actin capping proteins: insights from the crystal structure of cytoplasmic Cap32/34 from Dictyostelium discoideum
    Christian Eckert
    Abteilung NMR basierte Strukturbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg 11, D 37077, Gottingen, Germany
    BMC Struct Biol 12:12. 2012
    Capping protein (CP), also known as CapZ in muscle cells and Cap32/34 in Dictyostelium discoideum, plays a major role in regulating actin filament dynamics. CP is a ubiquitously expressed heterodimer comprising an α- and β-subunit...
  69. pmc Phosphoprotein abundance changes in hypertensive cardiac remodeling
    Kumar Kotlo
    Department of Medicine, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60612, USA
    J Proteomics 77:1-13. 2012
    ..Among these were (1) myofilament proteins, including alpha-tropomyosin and myosin regulatory light chain 2, cap Z interacting protein (cap ZIP), and tubulin β5; (2) mitochondrial proteins, including pyruvate dehydrogenase α, ..
  70. pmc Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
    Ahmed Elbediwy
    Department of Cell Biology, Institute of Ophthalmology, University College London, EC1V 9EL London, England, UK
    J Cell Biol 198:677-93. 2012
    ..The filamentous actin-capping protein CapZ also associated with the SH3BP1 complex and was required for control of actin remodeling...
  71. pmc Thermodynamic and kinetic analysis of peptides derived from CapZ, NDR, p53, HDM2, and HDM4 binding to human S100B
    Lucas N Wafer
    Center for Biotechnology and Interdisciplinary Studies and Department of Biology, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA
    Biochemistry 51:7189-201. 2012
    ..Previously, peptides derived from CapZ, p53, NDR, HDM2, and HDM4 have been shown to interact with S100B in a calcium-dependent manner...
  72. pmc Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587
    Bior K Bior
    Department of Biology, University of Vermont, Burlington, VT 05405, USA
    FEBS Lett 587:60-6. 2013
    ..Furthermore a Cin85 Ser587 phosphomimetic disrupts the Dab1-Cin85 complex without affecting the Cin85-CapZ complex...
  73. ncbi Variant cDNAs encoding proteins similar to the alpha subunit of chicken CapZ
    J A Cooper
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri
    Cell Motil Cytoskeleton 18:204-14. 1991
    ..previously isolated from a chicken embryo library by screening with antibodies against the alpha subunit of chicken CapZ. cDNAs with a new coding region, called alpha 2, were found in addition to ones with the alpha 1 coding region...
  74. ncbi cDNAs encoding the beta subunit of cap Z, the actin-capping protein of the Z line of muscle
    J E Caldwell
    Department of Cell Biology and Physiology, Washington University Medical School, St Louis, Missouri 63110
    J Biol Chem 264:12648-52. 1989
    Three cDNAs encoding the beta chain of Cap Z have been isolated from lambda gt11 chicken libraries screened with antibodies...
  75. ncbi Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes
    N A Maun
    University of Florida College of Medicine, Division of Infectious Diseases, Gainesville, 32610, USA
    Biochemistry 35:3518-24. 1996
    ..Western blot analysis identified the protein as the nonmuscle isoform of the heterodimeric capping protein capZ. Human PMN capZ has an apparent disassociation constant of 3 nM for capping in the presence or absence of ..
  76. ncbi Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin
    P A Kuhlman
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 36:13461-72. 1997
    b>CapZ ("capping protein") is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and is proposed to function in regulating actin filament dynamics as well as ..
  77. pmc Identification of the binding site on S100B protein for the actin capping protein CapZ
    P M Kilby
    Department of Biochemistry and Biological NMR Centre, University of Leicester, United Kingdom
    Protein Sci 6:2494-503. 1997
    ..in spectra of 15N-labeled protein to locate the site that binds a peptide corresponding to residues 265-276 from CapZ alpha, the actin capping protein...
  78. ncbi Cloning of ARE-containing genes by AU-motif-directed display
    O Dominguez
    University Hospital Germans Trias i Pujol, Autonomous University of Barcelona, Barcelona, 08916, Spain
    Genomics 54:278-86. 1998
    ..These data demonstrate the efficiency of the system and support the notion that numerous genes falling into those categories remain unidentified and that they can be cloned by this method...
  79. pmc Annealing accounts for the length of actin filaments formed by spontaneous polymerization
    D Sept
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093 0365, USA
    Biophys J 77:2911-9. 1999
    ..the observed average length of filaments in two types of experiments: 1) filaments formed from a wide range of highly purified actin monomer concentrations, and 2) filaments formed from 24 microM actin over a range of CapZ concentrations.
  80. ncbi Interaction of the p62 subunit of dynactin with Arp1 and the cortical actin cytoskeleton
    J A Garces
    Department of Cell Biology, University of Massachusetts Medical School, Worcester 01605, USA
    Curr Biol 9:1497-500. 1999
    ..Dynactin is a multi-subunit complex that contains a short actin-related protein 1 (Arp 1) filament with capZ at the barbed end and p62 at the pointed end [5]...
  81. ncbi Telethonin and other new proteins of the Z-disc of skeletal muscle
    G Faulkner
    International Centre for Genetic Engineering and Biotechnology, Padriciano, Trieste, Italy
    IUBMB Life 51:275-82. 2001
    ..A greater knowledge of Z-disc proteins and their interactions is essential for understanding their role in the structure and function of muscle...
  82. ncbi Actin capping protein: an essential element in protein kinase signaling to the myofilaments
    W Glen Pyle
    Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Ill 60612, USA
    Circ Res 90:1299-306. 2002
    Actin capping protein (CapZ) binds the barbed ends of actin at sarcomeric Z-lines. In addition to anchoring actin, Z-discs bind protein kinase C (PKC)...
  83. ncbi Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12
    Keith G Inman
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108 N Greene St, Baltimore, MD 21201, USA
    J Mol Biol 324:1003-14. 2002
    ..is reported for Ca(2+)-loaded S100B bound to a 12-residue peptide, TRTK-12, from the actin capping protein CapZ (alpha1 or alpha2 subunit, residues 265-276: TRTKIDWNKILS)...
  84. ncbi V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein
    Masato Taoka
    Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Hachioji shi, Tokyo 192 0397, Japan
    J Biol Chem 278:5864-70. 2003
    ..with V-1, which were identified as the alpha and beta subunits of the capping protein (CP, alternatively called CapZ or beta-actinin). CP regulates actin polymerization by capping the barbed end of the actin filament. The V-1...
  85. ncbi Anandamide-induced depressor effect in spontaneously hypertensive rats: role of the vanilloid receptor
    Jianping Li
    Department of Medicine and Pharmacology and Toxicology, Michigan State University, East Lansing 48824, USA
    Hypertension 41:757-62. 2003
    ..depressor effect in spontaneously hypertensive rats (SHR), we used a selective VR1 antagonist capsazepine (CAPZ) and a selective cannabinoid type 1 receptor antagonist SR141716A in conjunction with a VR1 agonist capsaicin in ..
  86. pmc Crystal structure of CapZ: structural basis for actin filament barbed end capping
    Atsuko Yamashita
    Laboratory for Structural Biochemistry, RIKEN Harima Institute at SPring 8, 1 1 1 Kouto, Mikazuki, Sayo, Hyogo, 679 5148, Japan
    EMBO J 22:1529-38. 2003
    ..Here we describe the crystal structure of the chicken sarcomeric capping protein CapZ at 2.1 A resolution...
  87. ncbi Actin binding proteins: regulation of cytoskeletal microfilaments
    C G Dos Remedios
    Institute for Biomedical Research, Muscle Research Unit, Department of Anatomy and Histology, University of Sydney, Australia
    Physiol Rev 83:433-73. 2003
    ..In this review we selected several ABPs (ADF/cofilin, profilin, gelsolin, thymosin beta4, DNase I, CapZ, tropomodulin, and Arp2/3) that regulate actin-driven assembly, i.e...
  88. pmc Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1
    D Mark Eckley
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Mol Biol Cell 14:2645-54. 2003
    ..present in a protein complex localized at the pointed end of the Arp1 minifilament, whereas actin capping protein (CapZ) is present at the barbed end. Either might cooperate with conventional actin to cap Arp1...
  89. ncbi Function and regulation of the vanilloid receptor in rats fed a high salt diet
    Jianping Li
    Department of Medicine and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    J Hypertens 21:1525-30. 2003
    ..To test the hypothesis that activation of the vanilloid receptor (VR1) by high salt intake prevents salt-induced increases in arterial pressure via stimulation of release of calcitonin gene-related peptide (CGRP) from sensory nerves...
  90. ncbi Hippocampal protein-protein interactions in spatial memory
    Thomas J Nelson
    Blanche Rockefeller Neurosciences Institute, Rockville, Maryland 20850, USA
    Hippocampus 14:46-57. 2004
    ..Interactions between complexin and its targets (p25alpha and Drac1-like protein) and the interaction between CapZ and tubulin were calcium-dependent...
  91. ncbi Effect of ionizing irradiation on human esophageal cancer cell lines by cDNA microarray gene expression analysis
    Hideki Bo
    Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
    J Nippon Med Sch 71:172-80. 2004
    ..UBE2M, RPL6, PDGFRL, TRAF2, TNFAIP6, ITGB4, GSTM3, and SP3 and common downregulated genes involved NFIL3, SMARCA2, CAPZA1, MetAP2, CITED2, DAP3, MGAT2, ATRX, CIAO1, and STAT6...
  92. ncbi Searching for the missing link: a role for the actin capping protein in heart failure
    W Glen Pyle
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Can J Cardiol 20:1429-32. 2004
    ..Using the actin capping protein (CapZ) as a representative of the Z-disc, it was found that decreasing CapZ enhances force development and inhibits ..
  93. pmc Differentially expressed transcripts from phenotypically identified olfactory sensory neurons
    Tun Tzu Yu
    Department of Physiology and The Cellular and Molecular Neuroscience of Sensory Systems Program, The University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Comp Neurol 483:251-62. 2005
    ..that participate in these biological processes, including ATP5g3, Ndufa9, Sqrdl, Mdh1, Got1, beta-2 tubulin, Capza1, Bin3, Tom1, Acl6, and similar to O-MACS. Three transcripts had restricted expression patterns...
  94. ncbi Intracellular cAMP controls a physical association of V-1 with CapZ in cultured mammalian endocrine cells
    Masashi Kitazawa
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Biochem Biophys Res Commun 331:181-6. 2005
    ..to control tyrosine hydroxylase (TH) gene expression and transmitter release in PC12D cells, associates with CapZ, an actin capping protein, and thereby regulates actin polymerization in vitro...
  95. pmc The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ
    Claire E Eyers
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 389:127-35. 2005
    ..It interacted specifically with the F-actin capping protein CapZ in splenocytes, and was therefore termed 'CapZIP' (CapZ-interacting protein)...
  96. ncbi The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy
    Nathan T Wright
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N Greene St, Baltimore, MD 21201, USA
    J Mol Biol 353:410-26. 2005
    ..exposes a hydrophobic cleft, defined by residues in the hinge region, the C terminus, and regions of helix 3, which are important for the interaction between S100A1 and a peptide (TRTK-12) derived from the actin-capping protein CapZ.
  97. ncbi WNT2B: comparative integromics and clinical applications (Review)
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Mol Med 16:1103-8. 2005
    ..Here, comparative integromics analyses on WNT2B and its clinical applications are reviewed. WNT2B-ST7L-CAPZA1 locus at human chromosome 1p13.2 and WNT2-ST7-CAPZA2 locus at human chromosome 7q31...
  98. ncbi Endothelin-1 mobilizes profilin-1-bound PIP2 in cardiac muscle
    Nathan J Evans
    Department of Physiology, University of Wisconsin Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA
    Exp Biol Med (Maywood) 231:882-7. 2006
    ..cytoskeletal proteins were found to contain tightly bound PIP2, including profilin-1 (approximately 15 kDa), capZ (approximately 32 kDa), gCap39, (approximately 39 kDa) and alpha-actinin (approximately 106 kDa)...
  99. ncbi Control of cardiac myofilament activation and PKC-betaII signaling through the actin capping protein, CapZ
    W Glen Pyle
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Mol Cell Cardiol 41:537-43. 2006
    Actin capping protein (CapZ) anchors the barbed ends of sarcomeric actin to the Z-disc...
  100. pmc CapZ-lipid membrane interactions: a computer analysis
    James Smith
    Friedrich Alexander University of Erlangen Nuremberg Center for Medical Physics and Technology, Biophysics Group Henkestrasse 91, 91052 Erlangen, Germany
    Theor Biol Med Model 3:30. 2006
    b>CapZ is a calcium-insensitive and lipid-dependent actin filament capping protein, the main function of which is to regulate the assembly of the actin cytoskeleton...
  101. pmc The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein
    David A Canton
    Regulatory Biology and Functional Genomics Research Group, Siebens Drake Medical Research Institute, Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 281:36347-59. 2006
    ....

Research Grants5

  1. R John Solaro; Fiscal Year: 2016
    ..regulates cell lengthening by phosphorylation of focal adhesion kinase at the costamere leading to actin capping by CapZ. In Project 3 (LewandoskI), the overall objective is to elucidate the potential for, and the extent to which ..
  2. CapZ, PKC Signaling and Control of Sarcomere Function
    C Sumandea; Fiscal Year: 2006
    ..We reported recently that transgenic mice engineered to display a reduction in the Z-disc actin capping protein, CapZ, affect the myofilament response to Ca2+ and also induce alterations in PKC Z-disc localization...
  3. Gordon Research Conference on Motile and Contractile Sys
    Velia Fowler; Fiscal Year: 2003
    ..An informal Technical Tutorial will be held on one afternoon in which advantages and caveats of new developments in quantitative light microscopy and digital image analysis are discussed. ..
  4. CAPPING ACTIN GROWTH IN ERYTHROID NONERYTHROID CELLS
    Velia Fowler; Fiscal Year: 2004
    ....
  5. INTEGRATION OF ACTIN BEADED FILAMENT SYSTEM IN THE LENS
    Velia Fowler; Fiscal Year: 2003
    ....