CAMK4

Summary

Gene Symbol: CAMK4
Description: calcium/calmodulin dependent protein kinase IV
Alias: CaMK IV, CaMK-GR, caMK, calcium/calmodulin-dependent protein kinase type IV, CAM kinase IV, CAM kinase- GR, brain Ca(2+)-calmodulin-dependent protein kinase type IV, brain Ca++-calmodulin-dependent protein kinase type IV, calcium/calmodulin-dependent protein kinase type IV catalytic chain
Species: human

Top Publications

  1. ncbi Evidence for the existence of Ca2+/calmodulin-dependent protein kinase IV kinase isoforms in rat brain
    S Okuno
    Department of Biochemistry, Asahikawa Medical College, Hokkaido
    J Biochem 119:1176-81. 1996
  2. ncbi A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR
    T Chatila
    Department of Pediatrics, Washington University School of Medicine, St Louis Missouri 63110, USA
    J Biol Chem 271:21542-8. 1996
  3. ncbi Ca(2+)-dependent gene expression mediated by MEF2 transcription factors
    F Blaeser
    Department of Pediatrics, Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 275:197-209. 2000
  4. ncbi An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory
    H Kang
    Howard Hughes Medical Institute, New Haven, CT 06511, USA
    Cell 106:771-83. 2001
  5. ncbi Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus
    Shannon M Lemrow
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:11664-71. 2004
  6. pmc Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells
    Maddalena Illario
    Department of Molecular and Cellular Biology and Pathology, Federico II University of Naples, Italy
    Blood 111:723-31. 2008
  7. ncbi Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit
    M K Jang
    Center for Ligand and Transcription, Chonnam National University, Kwangju 500 757, Seoul 151 742, Korea
    J Biol Chem 276:20005-10. 2001
  8. ncbi Effect of neuronal nitric oxide synthase inhibition on CA2+/calmodulin kinase kinase and CA2+/calmodulin kinase IV activity during hypoxia in cortical nuclei of newborn piglets
    A B Zubrow
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA
    Neuroscience 125:937-45. 2004
  9. ncbi MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo
    O Heidenreich
    Institut fur Zellbiologie, Abteilung Molekularbiologie, Universitat Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 274:14434-43. 1999
  10. ncbi Subcellular distributions of rat CaM kinase phosphatase N and other members of the CaM kinase regulatory system
    Takako Kitani
    Department of Biochemistry, Asahikawa Medical College, Japan
    J Neurochem 86:77-85. 2003

Research Grants

  1. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
  2. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 2009
  3. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2013
  4. CaM Kinase Cascades in Endocrine Cells
    Anthony R Means; Fiscal Year: 2010
  5. George C Tsokos; Fiscal Year: 2016
  6. Chengcheng Zhang; Fiscal Year: 2016
  7. MOLECULAR BIOLOGY OF BRAIN PROTEIN PHOSPHORYLATION
    James Sikela; Fiscal Year: 1993
  8. GENETIC ANALYSIS OF SIGNALING BY CARDIAC ENDOTHELIN-1
    Ralph Shohet; Fiscal Year: 2004
  9. Estrogen and CaM Kinase IV in the Limbic System
    ROCHELLE COHEN; Fiscal Year: 2006
  10. BIOLOGY OF THE TESTIS
    ANTHONY MEANS; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications140 found, 100 shown here

  1. ncbi Evidence for the existence of Ca2+/calmodulin-dependent protein kinase IV kinase isoforms in rat brain
    S Okuno
    Department of Biochemistry, Asahikawa Medical College, Hokkaido
    J Biochem 119:1176-81. 1996
    ..Thus, at least two distinct isoforms of CaM-kinase IV kinase appear to exist in the brain...
  2. ncbi A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR
    T Chatila
    Department of Pediatrics, Washington University School of Medicine, St Louis Missouri 63110, USA
    J Biol Chem 271:21542-8. 1996
    ..This three-step requirement is unique among the multifunctional Ca2+/calmodulin-dependent kinases...
  3. ncbi Ca(2+)-dependent gene expression mediated by MEF2 transcription factors
    F Blaeser
    Department of Pediatrics, Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 275:197-209. 2000
    ..These results identify MEF2 proteins as effectors of a pathway of gene induction in T lymphocytes which integrates diverse Ca(2+) activation signals and may be broadly operative in several tissues...
  4. ncbi An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory
    H Kang
    Howard Hughes Medical Institute, New Haven, CT 06511, USA
    Cell 106:771-83. 2001
    ..These results indicate that neural activity-dependent CaMKIV signaling in the neuronal nucleus plays an important role in the consolidation/retention of hippocampus-dependent long-term memory...
  5. ncbi Catalytic activity is required for calcium/calmodulin-dependent protein kinase IV to enter the nucleus
    Shannon M Lemrow
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:11664-71. 2004
    ..We propose that sequestration of CaMKK may be the molecular mechanism by which catalytically inactive mutants of CaMKIV exert their "dominant-negative" functions within the cell...
  6. pmc Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells
    Maddalena Illario
    Department of Molecular and Cellular Biology and Pathology, Federico II University of Naples, Italy
    Blood 111:723-31. 2008
    ..Although isolated Camk4-/- DCs are able to acquire the phenotype typical of mature cells and release normal amounts of cytokines in ..
  7. ncbi Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit
    M K Jang
    Center for Ligand and Transcription, Chonnam National University, Kwangju 500 757, Seoul 151 742, Korea
    J Biol Chem 276:20005-10. 2001
    ..Consistent with these results, cotransfected CaMKIV dramatically stimulated the NFkappaB transactivation in mammalian cells. From these results, NFkappaB is suggested to be a novel downstream effector molecule of CaMKIV...
  8. ncbi Effect of neuronal nitric oxide synthase inhibition on CA2+/calmodulin kinase kinase and CA2+/calmodulin kinase IV activity during hypoxia in cortical nuclei of newborn piglets
    A B Zubrow
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA
    Neuroscience 125:937-45. 2004
    ..To test this hypothesis, CaM kinase kinase and CaM kinase IV activities were determined in normoxic, hypoxic, NNLA-treated hypoxic, and 7-NINA-treated hypoxic piglets...
  9. ncbi MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo
    O Heidenreich
    Institut fur Zellbiologie, Abteilung Molekularbiologie, Universitat Tubingen, D 72076 Tubingen, Germany
    J Biol Chem 274:14434-43. 1999
    Several growth factor- and calcium-regulated kinases such as pp90(rsk) or CaM kinase IV can phosphorylate the transcription factor serum response factor (SRF) at serine 103 (Ser-103)...
  10. ncbi Subcellular distributions of rat CaM kinase phosphatase N and other members of the CaM kinase regulatory system
    Takako Kitani
    Department of Biochemistry, Asahikawa Medical College, Japan
    J Neurochem 86:77-85. 2003
    ..indicate that CaM kinase I, CaM kinase kinase beta, and CaM kinase phosphatase occur in the cytoplasm and that CaM kinase IV, CaM kinase kinase alpha (and CaM kinase kinase beta in some cell types and tissues), and CaM kinase ..
  11. ncbi Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice
    Takayuki Akimoto
    Department of Medicine, Duke University Medical Center, Durham, NC 27704, USA
    Am J Physiol Cell Physiol 287:C1311-9. 2004
    ..stimulation (2 h at 10 Hz) likewise increased PGC-1alpha mRNA expression in tibialis anterior muscles in both Camk4(-/-) and wild-type mice...
  12. doi Difference in physiogenomics between male and female infertility
    V Wiwanitkit
    Wiwanitkit House, Bangkhae, Bangkok, Thailand Hainan Medical College, Hainan, China
    Andrologia 40:158-60. 2008
    ..According to this work, there is only one identified physiogenomic relationship on chromosome 5 (CAMK4) for male but there are four identified physiogenomic relationships on chromosome 12 (CD9), chromosome 19 (BSG), ..
  13. ncbi Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription
    Lori Redmond
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 34:999-1010. 2002
    We report that CaM kinase IV and CREB play a critical role in mediating calcium-induced dendritic growth in cortical neurons...
  14. ncbi CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV
    S Chawla
    Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 281:1505-9. 1998
    ..These results identify CBP as a signal-regulated transcriptional coactivator and define a regulatory role for nuclear calcium and cAMP in CBP-dependent gene expression...
  15. ncbi Functional proteins involved in regulation of intracellular Ca(2+) for drug development: role of calcium/calmodulin-dependent protein kinases in ischemic neuronal death
    Shigetoshi Yano
    Department of Neurosurgery, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University Graduate School, Kumamoto
    J Pharmacol Sci 97:351-4. 2005
    ..Calcium/calmodulin (CaM)-dependent protein kinase kinase (CaM-KK) is an upstream kinase for CaM kinase IV (CaM-KIV) that was reported to prevent apoptosis through phosphorylation of CREB (cyclic AMP responsive ..
  16. ncbi Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice
    T J Ribar
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 20:RC107. 2000
    ..To understand the physiological importance of CaMKIV, we disrupted the mouse Camk4 gene. The CaMKIV null mice displayed locomotor defects consistent with altered cerebellar function...
  17. doi PLC/CAMK IV-NF-kappaB involved in the receptor for advanced glycation end products mediated signaling pathway in human endothelial cells
    Jie You
    Research Center of Molecular Medicine, Fujian Medical University, No 88 Jiaotong Road, Fuzhou, Fujian 350004, PR China
    Mol Cell Endocrinol 320:111-7. 2010
    ..C beta 1 (PLC beta 1), phospholipase C beta 4 (PLC beta 4) and calcium/calmodulin-dependent protein kinase IV (CAMK IV) which associated with Ca(2+) signaling were upregulated...
  18. doi Protein kinase A activates and phosphorylates RORα4 in vitro and takes part in RORα activation by CaMK-IV
    Michael Ermisch
    Institute for Pharmaceutical Chemistry, Goethe University Frankfurt, Max von Laue Str 9, 60438 Frankfurt am Main, Germany
    Biochem Biophys Res Commun 408:442-6. 2011
    ..Inhibition of PKA with the selective kinase inhibitor H89 inhibits dBcAMP mediated as well as CaMK-IV triggered increase in RORα4 transcriptional activity...
  19. pmc CaMK4 Gene Deletion Induces Hypertension
    Gaetano Santulli
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Naples, Italy G S, E C, D S, C D G, A A, B T
    J Am Heart Assoc 1:e001081. 2012
    ..a recent genome-wide analysis indicated an association between hypertension and a single-nucleotide polymorphism (rs10491334) of the human CaMKIV gene (CaMK4), which suggests a role for this kinase in the regulation of vascular tone.
  20. pmc Specificity of calcium/calmodulin-dependent protein kinases in mouse egg activation
    Sergey Medvedev
    Department of Biology University of Pennsylvania Philadelphia, PA USA
    Cell Cycle 13:1482-8. 2014
    ..In contrast, none of the Camk2g(-/-) MII eggs expressing Camk1 or Camk4 activate in response to SrCl 2 treatment...
  21. doi A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells
    Sara Monaco
    Dipartimento di Scienze Mediche Traslazionali, Federico II University, Naples, Italy
    Cell Signal 27:204-14. 2015
    ..Our data reveal a novel cross-talk between CaMKII and CaMKIV and suggest that CaMKII suppresses the expression of CaMKIV to promote leukemia cell proliferation. ..
  22. doi Experience-dependent upregulation of multiple plasticity factors in the hippocampus during early REM sleep
    Julien Braga Calais
    Laboratório de Neurociências LIM 27, Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo USP, Departamento e Instituto de Psiquiatria, Sao Paulo, Brazil Laboratório Cesar Timo Iaria, Instituto de Ensino e Pesquisa, Hospital Sirio Libanes, Sao Paulo, Brazil
    Neurobiol Learn Mem 122:19-27. 2015
    ..Experience-dependent changes during sleep were not significant in the hippocampus for Bdnf, Camk4, Creb1, and Nr4a1, and no differences were detected between exposed and control SWS groups for any of the genes ..
  23. pmc A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation
    Jian Da Wang
    a Department of Neurology Jiangsu Key Laboratory of Translational Research and Therapy for Neuro Psycho Diseases The Second Affiliated Hospital of Soochow University Soochow University Suzhou, China
    Autophagy 11:2057-2073. 2015
    ..a critical role of intracellular Ca2+ elevation, followed by the enhanced phosphorylation of CAMK4 (calcium/calmodulin-dependent protein kinase IV) and CREB (cAMP responsive element binding protein) in the ..
  24. doi [Association between gene polymorphism of calcium/calmodulin-dependent kinase 4 and efficacy of amlodipine in the treatment of hypertension in Chinese Han nationality]
    Guangwei Zhong
    Internatioal Medical Center, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 41:777-82. 2016
    To evaluate the association between single nucleotide polymorphisms of calcium/calmodulin-dependent kinase 4 (CAMK4) and the therapeutic effect of amlodipine in essential hypertensive patients in Chinese Han nationality.

  25. ncbi Requirement for integration of phorbol 12-myristate 13-acetate and calcium pathways is preserved in the transactivation domain of NFAT1
    C Garcia-Rodriguez
    Department of Pathology, Harvard Medical School, and the Center for Blood Research, Boston, MA 02115, USA
    Eur J Immunol 30:2432-6. 2000
    ..can be mimicked by coexpression of activated versions of two CaM-dependent enzymes, calcineurin and CaM kinase IV. Our data indicate that a 144-amino acid segment of NFAT1, containing the N-terminal TAD but lacking the DNA-..
  26. pmc A consensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons
    Jiuyong Xie
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095 1662, USA
    RNA 11:1825-34. 2005
    ..Here, we report that similar Ca(++) regulation of splicing, mediated by L-type calcium channels and CaM kinase IV, occurs in cultured neurons and in the brain...
  27. doi Curcumin specifically binds to the human calcium-calmodulin-dependent protein kinase IV: fluorescence and molecular dynamics simulation studies
    Nasimul Hoda
    a Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India
    J Biomol Struct Dyn 34:572-84. 2016
    Calcium-calmodulin-dependent protein kinase IV (CAMK4) plays significant role in the regulation of calcium-dependent gene expression, and thus, it is involved in varieties of cellular functions such as cell signaling and neuronal ..
  28. ncbi Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene
    Z Sun
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 270:29507-14. 1995
    A 42-kilobase pair region of rat DNA containing the Ca2+/calmodulin-dependent protein kinase IV (CaM kinase IV) gene has been cloned and characterized...
  29. ncbi Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases
    S Okuno
    Department of Biochemistry, Asahikawa Medical College, Asahikawa 078 8510, Japan
    J Biochem 127:965-70. 2000
    ..However, the specific activities of CaM-kinase kinase alpha and CaM-kinase II as to the activation of PKB were more than three orders of magnitude lower than that of 3-phosphoinositide-dependent protein kinase 1 (PDK1)...
  30. ncbi Activation of Ca2+/calmodulin-dependent protein kinase I in cultured rat hippocampal neurons
    Akiyoshi Uezu
    Department of Pharmacology, Kumamoto University School of Medicine, Kumamoto, Japan
    J Neurochem 82:585-93. 2002
    ..protein kinase (CaM) kinase I in the hippocampal neurons and compared them with that of CaM kinase IV. Increased activation of CaM kinase I occurred by stimulation with glutamate and depolarization in cultured ..
  31. ncbi Effect of post-hypoxic MgSO(4) administration in utero on Ca(2+)-influx and Ca(2+)/calmodulin kinase IV activity in cortical neuronal nuclei
    Dev Maulik
    Department of Obstetrics and Gynecology, Winthrop University Hospital, 259 First Street, Mineola, NY 11501, USA
    Neurosci Lett 386:127-32. 2005
    Previously we have demonstrated that in utero hypoxia results in increased nuclear Ca(2+)-influx and increased CaM kinase IV activity in neuronal nuclei of the guinea pig fetus...
  32. doi Arsenic down-regulates the expression of Camk4, an important gene related to cerebellar LTD in mice
    Yanyan Wang
    Department of Occupational and Environmental of Health, Dalian Medical University, Liaoning, PR China
    Neurotoxicol Teratol 31:318-22. 2009
    ..group than controls and the down-regulated expression of Ca(2+)/calmodulin dependent protein kinase IV (Camk4), a very important regulator in the LTD pathway...
  33. doi Thyroid hormone regulation of gene expression in the developing rat fetal cerebral cortex: prominent role of the Ca2+/calmodulin-dependent protein kinase IV pathway
    Beatriz Morte
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, Madrid, Spain
    Endocrinology 151:810-20. 2010
    ..differentially expressed genes were related to each other centered on the Ca(2+) and calmodulin-activated kinase (Camk4) pathway...
  34. doi Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability
    Yun Hee Choi
    School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea
    Biochim Biophys Acta 1833:69-79. 2013
    ..These results suggest that phosphorylated Notch1-IC by CaMKIV increases Notch1-IC stability, which enhances osteoclast differentiation...
  35. doi Late maternal hypothyroidism alters the expression of Camk4 in neocortical subplate neurons: a comparison with Nurr1 labeling
    D Navarro
    Department Histology and Anatomy, Universidad Miguel Hernandez, Sant Joan d Alacant, Alicante, Spain
    Cereb Cortex 24:2694-706. 2014
    ..Expression of neocortical Ca(2+)/calmodulin kinase IV (Camk4), a genomic target of thyroid hormone, and nuclear receptor-related 1 protein (Nurr1), a postnatal marker of ..
  36. doi Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice
    Hui Young Lee
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA
    Diabetologia 57:1232-41. 2014
    ..Activation of CAMK4 also increases the content of type I muscle fibres, PGC-1α level and mitochondrial content...
  37. pmc KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice
    Tomohiro Koga
    Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Autoimmunity 47:445-50. 2014
    ..We have reported that calcium/calmodulin-dependent protein kinase IV (CaMK4) deficient MRL/lpr mice display less disease activity by promoting IL-2 production and increasing the activity of ..
  38. pmc Crocin suppresses LPS-stimulated expression of inducible nitric oxide synthase by upregulation of heme oxygenase-1 via calcium/calmodulin-dependent protein kinase 4
    Ji Hee Kim
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Jangjeon Dong, Keumjeong Gu, Busan 609 735, Republic of Korea
    Mediators Inflamm 2014:728709. 2014
    ..Ca(2+) mobilization from intracellular pools and phosphorylation of Ca(2+)/calmodulin-dependent protein kinase 4 (CAMK4)...
  39. doi Jieduquyuziyin prescription suppresses IL-17 production and Th17 activity in MRL/lpr mice by inhibiting expression of Ca(2+)/calmodulin-dependent protein kinase-4
    Bingjie Shui
    Zhejiang Chinese Medical University College of Life Science, Hangzhou, China
    J Nat Med 69:349-57. 2015
    ..with JP to ascertain if JP could improve SLE by the suppression of Ca(2+)/calmodulin-dependent protein kinase-4 (CaMK4) expression...
  40. doi A testis-specific gene within a widely expressed gene: Contrasting evolutionary patterns of two differentially expressed mammalian proteins encoded by a single gene, CAMK4
    Abinash Padhi
    Department of Animal and Avian Sciences, University of Maryland, College Park, 20742, MD, USA
    Anim Genet 46:683-92. 2015
    ..CaMKIV (Ca(2+) /calmodulin-dependent protein kinase IV) and CaS (calspermin)] that are encoded by a single gene, CAMK4. The multifunctional CaMKIV, which is expressed in multiple tissues including testis and ovary, is evolving at a ..
  41. doi CAMK4 gene variation is associated with hypertension in a Uygur population
    S Z Chen
    Department of Internal Medicine and Genetic Diagnosis Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Genet Mol Res 15:. 2016
    Considering that calcium/calmodulin-dependent kinase 4 (CAMK4) plays a pivotal role in blood pressure regulation, we investigated the association between a CAMK4 polymorphism (rs10491334) and hypertension in the Han, Kazak, and Uygur ..
  42. doi Region-specific activation of the AMPK system by cocaine: The role of D1 and D2 receptors
    Shijie Xu
    Clinical Research Institute, Seoul National University Hospital, 101 Daehak Ro, Jongno gu, Seoul 110 744, Republic of Korea
    Pharmacol Biochem Behav 146:28-34. 2016
    ..The phosphorylation levels of the upstream kinases Ser-431-LKB1 and Thr-196-CaMK4 were congruent with the changes in AMPK activity...
  43. doi Topiramate Confers Neuroprotection Against Methylphenidate-Induced Neurodegeneration in Dentate Gyrus and CA1 Regions of Hippocampus via CREB/BDNF Pathway in Rats
    Majid Motaghinejad
    Razi Drug Research Center and Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Hemmat High way, Beside Milad Tower, Tehran, 14496 14525, Iran
    Neurotox Res . 2017
    ..Expression of the total and phosphorylated CREB and BDNF in gene and protein levels, and gene expression of Ak1, CaMK4, MAPK3, PKA, and c-Fos levels were also measured. MPH significantly decreased motor activity in OFT...
  44. pmc Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene
    C A Ohmstede
    Department of Cell Biology, Burroughs Wellcome Co, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 88:5784-8. 1991
    ....
  45. ncbi cDNA sequence and differential expression of the mouse Ca2+/calmodulin-dependent protein kinase IV gene
    D A Jones
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262
    FEBS Lett 289:105-9. 1991
    ..Of the tissues examined, expression of the CaM kinase IV gene is restricted to brain and testis, where transcripts are differentially expressed to produce a kinase in ..
  46. ncbi Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation
    H Enslen
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    J Biol Chem 269:15520-7. 1994
    We have characterized Ca2+/calmodulin-dependent protein kinase IV (CaM kinase IV), expressed using the baculovirus/Sf9 cell system, to assess its potential role in Ca2+-dependent transcriptional regulation...
  47. ncbi Cloning and sequencing of a gene encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV and its expression confined to the mature cerebellar granule cells
    H Sakagami
    Department of Anatomy, Tohoku University School of Medicine, Sendai, Japan
    Brain Res Mol Brain Res 19:215-8. 1993
    A cDNA encoding the beta polypeptide of Ca2+/calmodulin-dependent protein kinase IV (CaM kinase IV) was isolated and sequenced from a rat cerebellar cDNA library...
  48. pmc Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade
    H Enslen
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Proc Natl Acad Sci U S A 93:10803-8. 1996
    ..These results establish a new Ca2+-dependent mechanism for regulating MAP kinase pathways and resultant transcription...
  49. ncbi Distribution of Ca2+/calmodulin-dependent protein kinase kinase alpha in the rat central nervous system: an immunohistochemical study
    Y Nakamura
    Department of Anatomy, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Neurosci Lett 204:61-4. 1996
    ..Thus, it was suggested that other types of CaM-kinase IV kinase might exist in the cerebellum, and the present CaM-kinase IV kinase was named as CaM-kinase kinase alpha...
  50. ncbi Molecular cloning of Ca2+/calmodulin-dependent protein kinase kinase beta
    T Kitani
    Department of Biochemistry, Asahikawa Medical College, Hokkaido
    J Biochem 122:243-50. 1997
    ..Western blot analysis revealed that CaM-kinase kinase beta significantly existed only in the brain. The enzyme was not significantly detected in the retina where CaM-kinase kinase alpha exists...
  51. ncbi The Ca2+/calmodulin-dependent kinase type IV is involved in the CD5-mediated signaling pathway in human T lymphocytes
    S I Gringhuis
    Division of Hematology, Department of Internal Medicine, University of Groningen, 9713 GZ Groningen, The Netherlands
    J Biol Chem 272:31809-20. 1997
    ..The expression of a dominant negative mutant of CaM kinase IV in T lymphocytes transfected with an IL-2 promoter-driven reporter construct completely abrogates the response ..
  52. ncbi Effects of chronic ethanol intake and its withdrawal on the expression and phosphorylation of the creb gene transcription factor in rat cortex
    S C Pandey
    Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Pharmacol Exp Ther 296:857-68. 2001
    ..catalytic subunits of PKA, and on the protein expression of Ca(2+)/calmodulin-dependent protein kinase IV (CaM kinase IV) and calcineurin in the rat cortex were also investigated...
  53. ncbi A new locus for hereditary gingival fibromatosis (GINGF2) maps to 5q13-q22
    S Xiao
    University of Science and Technology of China, Hefei, People s Republic of China
    Genomics 74:180-5. 2001
    ..31 at D5S1721 (theta = 0.00). Haplotype analysis placed the critical region in the interval defined by D5S1491 and D5S1453. Within this region, calcium/calmodulin-dependent protein kinase IV (CAMK4) is a strong candidate.
  54. doi Chronic ethanol intake-induced changes in open-field behavior and calcium/calmodulin-dependent protein kinase IV expression in nucleus accumbens of rats: naloxone reversal
    Jing Li
    Department of Pathophysiology, Nanjing Medical University, Nanjing 210029, China
    Acta Pharmacol Sin 29:646-52. 2008
    ..ethanol intake on the locomotor activity and the levels of calcium/calmodulin-dependent protein kinase IV (CaM kinase IV) in the nucleus accumbens (NAc) of rats...
  55. pmc Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:18953-62. 2009
    ..Our study has provided strong evidence for CaMKIV as a molecular link between Group I mGluRs and FMRP in ACC neurons and may help us to elucidate the pathogenesis of fragile X syndrome...
  56. pmc Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells
    David M Feliciano
    Department of Pharmacology and Toxicology, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 284:26466-81. 2009
    ..RA-induced repression of the CaMKIV signaling pathway may represent an early event in retinoid-dependent neuronal differentiation...
  57. pmc Major signaling pathways in migrating neuroblasts
    Konstantin Khodosevich
    Department of Clinical Neurobiology, Interdisciplinary Center for Neurosciences Heidelberg, Germany
    Front Mol Neurosci 2:7. 2009
    ..Thus, knockdown of Calm1, Gria1 (GluA1) and Camk4 (calmodulin-signaling network), Hdac2 and Hsbp1 (Akt1-DNA transcription network), Vav3 and Ppm1a (growth factor ..
  58. pmc Brain tissue energy dependence of CaM kinase IV cascade activation during hypoxia in the cerebral cortex of newborn piglets
    Maria Delivoria-Papadopoulos
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s, Hospital for Children, Philadelphia, PA 19102, USA
    Neurosci Lett 491:113-7. 2011
    The present study aims to investigate the dependence of CaM kinase IV cascade activation during hypoxia and tests the hypothesis that hypoxia-induced tyrosine phosphorylation of CaM and CaM kinase IV, activation of CaM kinase IV and ..
  59. pmc Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study
    Shad B Smith
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, North Carolina 27514, USA
    J Pain 12:T92-101. 2011
    ..Other genes were revealed as potential new genetic risk factors for TMD, including NR3C1, CAMK4, CHRM2, IFRD1, and GRK5...
  60. doi Functional heterogeneity of human effector CD8+ T cells
    Hiroshi Takata
    Center for AIDS Research, Kumamoto University, Kumamoto, Japan
    Blood 119:1390-8. 2012
    ..These differences were explained by the specific up-regulation of CAMK4, SPRY2, and IL-7R in the CXCR1(-) subset and that of pro-apoptotic death-associated protein kinase 1 (DAPK1) in ..
  61. doi Genome-wide disease association study in chewing tobacco associated oral cancers
    Renu Bhatnagar
    Reliance Life Sciences Pvt Ltd, Dhirubhai Ambani Life Sciences Center, Thane Belapur, Rabale, Navi Mumbai 400 701, India
    Oral Oncol 48:831-5. 2012
    ..of Genes and Genome Pathway database, indicated SNP association with several genes including GRIK2, RASGRP3, CAMK4, SYK, RAPTOR, FHIT, DCC, active in signal transduction; MMP2, CNTNAP2, PTPRJ associated with tumor cell migration; ..
  62. doi Novel mutations in calcium/calmodulin-dependent protein kinase IV (CAMK4) gene in infertile men
    A Khattri
    Centre for Cellular and Molecular Biology, Hyderabad, India
    Int J Androl 35:810-8. 2012
    Calcium/calmodulin-dependent protein kinase IV (CAMK4) is a multifunctional serine/threonine protein kinase, which plays an important role in the spermatogenesis by phosphorylating protamines...
  63. pmc Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus
    Tomohiro Koga
    Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 189:3490-6. 2012
    The activity of calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased in T cells from patients with systemic lupus erythematosus (SLE) and has been shown to reduce IL-2 production by promoting the effect of the ..
  64. pmc A model of the roles of essential kinases in the induction and expression of late long-term potentiation
    Paul Smolen
    Department of Neurobiology and Anatomy, W M Keck Center for the Neurobiology of Learning and Memory, The University of Texas Medical School at Houston, USA
    Biophys J 90:2760-75. 2006
    ..kinase (MAPK), and CaM kinase II (CAMKII) in the vicinity of the synapse, and activation of transcription by CaM kinase IV (CAMKIV) and MAPK. L-LTP is represented by increases in a synaptic weight...
  65. pmc Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse
    Majid Nikpay
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Hypertens Res 35:585-91. 2012
    ..uncovered numerous shared genes among substance use, stress response, obesity and hemodynamic traits, including CAMK4, CNTN4, DLG2, FHIT, GRID2, ITPR2, NOVA1 and PRKCE, forming network of interacting proteins, sharing synaptic ..
  66. pmc The CaMK4/CREB/IRS-2 cascade stimulates proliferation and inhibits apoptosis of β-cells
    Bo Liu
    Diabetes Research Group, School of Medicine, Division of Diabetes and Nutritional Sciences, King s College London, London, United Kingdom
    PLoS ONE 7:e45711. 2012
    ..response element-binding protein (CREB) and we recently demonstrated that Ca(2+)/calmodulin dependent kinase 4 (CaMK4) is upstream of CREB activation in β-cells...
  67. ncbi Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites
    D S Bredt
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 267:10976-81. 1992
    ..We demonstrate that purified NOS is labeled by a photoaffinity derivative of calmodulin. These recognition sites on NOS provide multiple means for regulation of NO levels and "cross-talk" between second messenger systems...
  68. pmc Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex
    K F Jensen
    Neurotoxicology Division, Environmental Protection Agency, Research Triangle Park, NC 27711
    Proc Natl Acad Sci U S A 88:2850-3. 1991
    ..Immunoblots confirmed these findings. Thus, CaM kinase-Gr may mediate and coordinate Ca2(+)-signaling within different subcellular compartments...
  69. ncbi Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV
    J M Sikela
    Department of Pharmacology, University of Colorado School of Medicine, Denver 80262
    Genomics 4:21-7. 1989
    ..On the basis of structural and immunological features, we refer to this new kinase as CaM Kinase IV. Two cDNA clones were used to identify CaM Kinase IV: The downstream clone, lambda ICM-1, contains the ..
  70. ncbi Full activation of brain calmodulin-dependent protein kinase IV requires phosphorylation of the amino-terminal serine-rich region by calmodulin-dependent protein kinase IV kinase
    S Okuno
    Department of Biochemistry, Asahikawa Medical College, Hokkaido
    J Biochem 117:686-90. 1995
    ..The initial phosphorylation occurred in the amino-terminal serine-rich region of CaM-kinase IV. Kinetic analysis revealed that the increase in the activity upon phosphorylation was due mainly to an increase in the Vmax values...
  71. ncbi Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase
    H Tokumitsu
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    J Biol Chem 270:19320-4. 1995
    ..These results are consistent with the hypothesis that CaM-kinases I and IV are regulated through a unique signal transduction cascade involving CaM-kinase kinase...
  72. ncbi Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase
    H Tokumitsu
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    J Biol Chem 269:28640-7. 1994
    ..Sun, P., Brickey, D., Soderling, S. H., Klamo, E., and Soderling, T.R. (1994) J. Biol. Chem. 269, 15520-15527)...
  73. ncbi cDNA cloning and expression of human calmodulin-dependent protein kinase IV
    T Kitani
    Department of Biochemistry, Asahikawa Medical College, Hokkaido
    J Biochem 115:637-40. 1994
    ..The antibody also cross-reacted with both isoforms of CaM-kinase IV from rat cerebellum, the apparent molecular weights being 62,000 and 64,000, respectively...
  74. pmc A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1
    G Mosialos
    Department of Medicine, Harvard Medical School, Boston, Massachusetts
    J Virol 68:1697-705. 1994
    ..In view of the key role played by LMP1 in B-lymphocyte immortalization by EBV, these findings implicate CaM kinase-Gr as a potential mediator of B-lymphocyte growth transformation...
  75. ncbi The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus
    M M Bland
    Wellcome Research Laboratories, Research Triangle Park, NC 27709
    Gene 142:191-7. 1994
    ..The human antiserum cross-reacts with the rat and mouse proteins and immunoprecipitates the active kinase...
  76. ncbi Requirements for calcium and calmodulin in the calmodulin kinase activation cascade
    H Tokumitsu
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 271:5617-22. 1996
    ....
  77. ncbi Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence
    A M Edelman
    Department of Pharmacology and Toxicology, State University of New York, Buffalo 14214, USA
    J Biol Chem 271:10806-10. 1996
    ..Both CaMKIK alpha and CaMKIK beta are also capable of activating CaM kinase IV. Activation of CaM kinase I and CaM kinase IV occurs via phosphorylation of an equivalent Thr residue within ..
  78. pmc Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18
    H Melander Gradin
    Department for Cell and Molecular Biology, University of Umea, Sweden
    Mol Cell Biol 17:3459-67. 1997
    ..on Ser-25 by the mitogen-activated protein kinase and on Ser-16 by the Ca2+/calmodulin-dependent kinase IV/Gr (CaMK IV/Gr)...
  79. ncbi Regulation of CREB phosphorylation by cAMP and Ca2+ in parotid acinar cells
    T Takuma
    Department of Oral Biochemistry, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Japan
    Biochem Mol Biol Int 43:563-70. 1997
    ..b>CaM kinase IV, a putative protein kinase for CREB in response to Ca2+ elevation, was undetectable in parotid acinar cells.
  80. ncbi CREB-induced transcriptional activation depends on mGluR6 in rod bipolar cells
    K Yoshida
    Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan
    Brain Res Mol Brain Res 57:241-7. 1998
    ..INL were also immunopositive for anti-protein kinase C alpha (PKC alpha), a marker of rod bipolar cells, while CaM kinase IV immunoreactivity was not detected in these cells...
  81. ncbi Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase
    M Matsushita
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 273:21473-81. 1998
    ..of the enzyme by calmodulin (CaM) also allows CaMKI to be phosphorylated and activated by a second enzyme, CaMK kinase (CaMKK)...
  82. ncbi Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain
    H Tokumitsu
    Helix Research Institute, Inc, 1532 3 Yana, Kisarazu shi, Chiba 292 0812, Japan
    J Biol Chem 274:15803-10. 1999
    ..kinase (CaM-KK) has been identified and cloned as an activator for two kinases, CaM kinase I (CaM-KI) and CaM kinase IV (CaM-KIV), and a recent report (Yano, S., Tokumitsu, H., and Soderling, T. R...
  83. ncbi Regulation of neuronal nitric-oxide synthase by calmodulin kinases
    Y Hayashi
    Department of Pharmacology, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 274:20597-602. 1999
    ..kinases (CaM kinases) including CaM kinase Ialpha (CaM-K Ialpha), CaM kinase IIalpha (CaM-K IIalpha), and CaM kinase IV (CaM-K IV), was studied...
  84. ncbi Ca(2+)/Calmodulin-dependent protein kinase cascade in Caenorhabditis elegans. Implication in transcriptional activation
    K Eto
    Helix Research Institute, Inc, 1532 3 Yana, Kisarazu shi, Chiba 292 0812, Japan
    J Biol Chem 274:22556-62. 1999
    ..elegans and is functionally operated both in vitro and in intact cells, and it may be involved in Ca(2+)-dependent nuclear events such as transcriptional activation through phosphorylation of CREB...
  85. pmc WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A
    C S Moreno
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 275:5257-63. 2000
    ..Thus, one mechanism of targeting and organizing PP2A with components of Ca(2+)-dependent signaling pathways may be through the molecular scaffolding proteins striatin and SG2NA...
  86. ncbi Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells
    K Komeima
    Departments of Pharmacology and Ophthalmology, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 275:28139-43. 2000
    ..Thus, our results indicate that Ca(2+) triggers cross-talk signal transduction between CaM kinase and NO and CaM-K IIalpha phosphorylating nNOS on Ser(847), which in turn decreases the gaseous second messenger NO in neuronal cells...
  87. ncbi Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression
    N Ban
    Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Japan
    Diabetes 49:1142-8. 2000
    ..These results suggest a mechanism in which ATF-2 regulates insulin gene expression in pancreatic beta-cells, with the transcriptional activity of ATF-2 being increased by an elevated concentration of calcium ions...
  88. pmc CaM kinase IV regulates lineage commitment and survival of erythroid progenitors in a non-cell-autonomous manner
    G A Wayman
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Cell Biol 151:811-24. 2000
    ....
  89. pmc Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin
    J Y Wu
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 21:6066-70. 2001
    Calspermin and Ca(2+)-calmodulin-dependent protein kinase IV (CaMKIV) are two proteins encoded by the Camk4 gene. CaMKIV is found in multiple tissues, including brain, thymus, and testis, while calspermin is restricted to the testis...
  90. ncbi Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis
    S Okuno
    Department of Biochemistry, Asahikawa Medical College, Asahikawa 078 8510, Japan
    J Biochem 130:503-13. 2001
    ..The changes in the activity of the enzyme upon phosphorylation appear to occur as a result of conformational changes induced by phosphorylation on several sites...
  91. ncbi Phosphorylation of calmodulin by Ca2+/calmodulin-dependent protein kinase IV
    Atsuhiko Ishida
    Department of Biochemistry, Asahikawa Medical College, Asahikawa, Japan
    Arch Biochem Biophys 407:72-82. 2002
    ..Thus, CaM-kinase IV activated by binding Ca2+/CaM can bind and phosphorylate another CaM with the aid of poly(Lys), leading to a decrease in the activity of CaM...
  92. ncbi Nitric oxide-mediated Ca2+/calmodulin-dependent protein kinase IV activity during hypoxia in neuronal nuclei from newborn piglets
    Alan B Zubrow
    Department of Pediatrics, College of Medicine, Drexel University, Philadelphia, PA, USA
    Neurosci Lett 335:5-8. 2002
    ..study tested the hypothesis that hypoxia results in increased Ca(2+)/calmodulin-dependent protein kinase IV (CaM kinase IV) activity and that inhibition of nitric oxide (NO) synthase by N-nitro-L-arginine (NNLA) prevents the hypoxia- ..
  93. ncbi The effect of hypocapnia (PaCO2 27 mmHg) on CaM kinase IV activity, Bax/Bcl-2 protein expression and DNA fragmentation in the cerebral cortex of newborn piglets
    Karen I Fritz
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, Neonatology Research Laboratories, Medical College of Pennsylvania, Philadelphia, PA 19129, USA
    Neurosci Lett 352:211-5. 2003
    ..of 27 mmHg for 1 hr results in increased neuronal nuclear Ca(++)/calmodulin-dependent protein kinase IV (CaM kinase IV) activity, pro-apoptotic protein expression and DNA fragmentation in the cerebral cortex of newborn piglets...
  94. ncbi The effect of moderate hypocapnic ventilation on nuclear Ca2+-ATPase activity, nuclear Ca2+ flux, and Ca2+/calmodulin kinase IV activity in the cerebral cortex of newborn piglets
    Karen I Fritz
    Department of Pediatrics, Drexel University College of Medicine, St Christopher s Hospital For Children, Neonatology Research Laboratories, Philadelphia, Pennsylvania 19134, USA
    Neurochem Res 29:791-6. 2004
    ..PCr) levels and increased nuclear high-affinity Ca++-ATPase activity, intranuclear Ca++ flux, and CaM kinase IV activity in neuronal nuclei of piglets...
  95. ncbi Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex
    Kristin A Anderson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:31708-16. 2004
    ..tightly regulated event requiring both Ca(2+)/CaM binding and phosphorylation of the kinase on T200 by an upstream CaMK kinase (CaMKK)...
  96. ncbi Generation of a polyclonal antibody that simultaneously detects multiple Ser/Thr protein kinases
    Isamu Kameshita
    Faculty of Agriculture, Department of Life Sciences, Kagawa University, Miki cho, Kagawa 761 0795, Japan
    J Biochem Biophys Methods 60:13-22. 2004
    ..The present anti-peptide antibody with a broad spectrum of cross-reactivity to multiple protein kinases may be a powerful tool for comprehensive analysis focused on protein kinases...
  97. ncbi Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells
    E Yamamori
    Department of Medicine, Nagoya University Graduate School of Medicine and Hospital, Nagoya 466 8550, Japan
    J Mol Endocrinol 33:639-49. 2004
    ..RT-PCR analysis confirmed the expression of CaMK as well as CRH mRNA in BE(2)C cells. When we introduced approximately 1...
  98. pmc Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation
    Fan Pan
    Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    EMBO J 24:2104-13. 2005
    ..CaMKIV-mediated nuclear export of Cabin1 is likely to account for a significant part of the requirement of CaMKIV during human T-cell activation...
  99. ncbi Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance
    Christine M Kitsos
    Department of Pharmacology and Cancer Biology, Duke University, Medical Center, Durham, North Carolina 27715, USA
    J Biol Chem 280:33101-8. 2005
    ..Re-expression of CaMKIV in Camk4-/- KLS cells results in the rescue of the proliferation defects in vitro as well as in the restoration of CBP and ..
  100. ncbi Post-translational excision of the carboxyl-terminal segment of CaM kinase phosphatase N and its cytosolic occurrence in the brain
    Takako Kitani
    Department of Biochemistry, Asahikawa Medical College, Asahikawa, Japan
    J Neurochem 96:374-84. 2006
    ..against the carboxyl-terminal segment of the enzyme, indicating its involvement in the deactivation of CaM kinase IV. Here, we show that the majority of the naturally occurring CaM kinase phosphatase N in the brain exists not ..

Research Grants19

  1. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
    ..alters MEK &ERK phosphorylation {Pardo, 2003 #162}, decreases CREB phosphorylation &activity of CaM kinase IV {Tardito, 2007 #163} in rat hippocampal neurons...
  2. NEUROCHEMICAL PHARMACOLOGY OF PHENCYCLIDINE
    Kenneth Johnson; Fiscal Year: 2009
    ..of the CRE binding protein (CREB) and the CREB binding protein (CPB) through intracellular Ca2+ activation of CaM kinase IV and the Ras/MEK/ERK pathway...
  3. Calcium Sensing Proteins in Depression
    Yogesh Dwivedi; Fiscal Year: 2013
    ..PI 4-kinase 2, inositol trisphosphate receptors, CREB, neuronal apoptotic inhibitory protein, CaM kinase II, CaM kinase IV, and calcineurin;3) the expression and/or functional characteristics of these target proteins...
  4. CaM Kinase Cascades in Endocrine Cells
    Anthony R Means; Fiscal Year: 2010
    ..Analysis of Camk4~'~ mice identified a CaMKIV cascade in hematopoeitic stem cells (HSC) and cerebellar granule cells that ..
  5. George C Tsokos; Fiscal Year: 2016
    ..antibodies present in the sera of patients with SLE cause translocation of Calcium/calmodulin kinase 4 (CaMK4) from the cytoplasm to the nucleus where it suppresses IL-2 production. In the lupus prone MRL...
  6. Chengcheng Zhang; Fiscal Year: 2016
    ..and to PirB and induce activation of tyrosine phosphotase SHP-2 and calcium/calmodulin-dependent protein kinase 4 (CAMK4)...
  7. MOLECULAR BIOLOGY OF BRAIN PROTEIN PHOSPHORYLATION
    James Sikela; Fiscal Year: 1993
    ..detailed molecular characterization of the gene encoding a new brain Ca++/calmodulin-dependent protein kinase (CaM kinase IV) will be developed using a partial-length cDNA as a starting point...
  8. GENETIC ANALYSIS OF SIGNALING BY CARDIAC ENDOTHELIN-1
    Ralph Shohet; Fiscal Year: 2004
    ..3) To determine the effect of ET-1 ablation on the response of the CNA, CamK4 and MAPK dependent hypertrophic pathways...
  9. Estrogen and CaM Kinase IV in the Limbic System
    ROCHELLE COHEN; Fiscal Year: 2006
    ..We propose that the Ca2+/calmodulin-dependent protein kinase IV (CaMK IV) pathway, "CaMK IV - CREB - phosphorylated CREB (pCREB) - BDNF," mediates some of the effects of long-term E2 ..
  10. BIOLOGY OF THE TESTIS
    ANTHONY MEANS; Fiscal Year: 2005
    ..b>Camk4-/- mice are male (and female) infertile, unable to mount a type 2 immune response and exhibit profound loss of ..
  11. MOLECULAR MECHANISMS REGULATING CD40L GENE EXPRESSION
    Francis Lobo; Fiscal Year: 2000
    ..Our preliminary data indicate that a second calcium/ calmodulin-dependent signal, mediated by CaM kinase IV/Gr, augments activity of the CD40L promoter...
  12. REGULATION OF CALMODULIN DEPENDENT PROTEIN KINASES
    ARTHUR EDELMAN; Fiscal Year: 1999
    ..Specifically to determine by immunoprecipitation techniques if CaM kinase I (or CaM kinase IV) forms complexes with its activating kinases (CaMKIKs) and evaluate whether phosphorylation of CaMKIKs ..
  13. TRANSCRIPTIONAL CONTROL OF CARDIAC HYPERTROPHY
    Eric Olson; Fiscal Year: 2002
    ..Calcineurin has also been shown to synergize with PKC and CaM kinase IV to activate the transcription of MEF2-responsive genes, but the mechanism involved has not been defined...
  14. IN VIVO CEREBRAL OXIDATIVE METABOLISM IN HYPOXIC NEWBORNS
    MARIA D DELIVORIA PAPADOPOULOS; Fiscal Year: 2010
    ..proposed studies will investigate the mechanism of activation of Ca++/calmodulin-dependent protein kinase IV (CaM kinase IV) during hypoxia that leads to activation of cyclic AMP-response element binding (CREB) protein and triggers ..
  15. NO-MEDIATED MODIFICATION OF NMDA RECEPTOR DURING HYPOXIA
    Om Mishra; Fiscal Year: 2006
    ..abstract_text> ..
  16. Cellular Signaling Mechanisms in Macrophage Activation.
    Joseph Cuschieri; Fiscal Year: 2007
    ..calcium results in the activation of regulatory kinases, such as calcium/calmodulin-dependent protein kinases (CaMK), leads to enhanced endotoxin-mediated signaling...
  17. NO-MEDIATED MODIFICATION OF NMDA RECEPTOR DURING HYPOXIA
    Om Mishra; Fiscal Year: 2008
    ..abstract_text> ..
  18. Genomic-wide Analysis of Oct 3/4 and Nanog Targets
    Soren Impey; Fiscal Year: 2010
    ..This set of studies will represent the most comprehensive analysis to date of the regulation of transcription factor binding in any metazoan system. ..
  19. Regulation of CBP by Synaptic Activity
    Soren Impey; Fiscal Year: 2005
    ..4) Analyze the regulation of CBP and CREB function in mice deficient for CaM kinase IV. This study seeks to dissect the biochemical events result in synaptic activity-mediated phosphorylation of ..