Genomes and Genes
Gene Symbol: CAMK2A
Description: calcium/calmodulin dependent protein kinase II alpha
Alias: CAMKA, calcium/calmodulin-dependent protein kinase type II subunit alpha, CaM kinase II alpha subunit, CaM-kinase II alpha chain, CaMK-II alpha subunit, CaMKIINalpha, caM kinase II subunit alpha, caMK-II subunit alpha, calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, calcium/calmodulin-dependent protein kinase II alpha-B subunit, calcium/calmodulin-dependent protein kinase type II alpha chain
Publications151 found, 100 shown here
- Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1C I Holmberg
Turku Centre for Biotechnology, University of Turku, Abo Akademi University, Finland
EMBO J 20:3800-10. 2001..Our study provides the first evidence that phosphorylation is essential for the transcriptional activity of HSF1, and hence for induction of the heat shock response...
- The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent mannerRani Dhavan
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 22:7879-91. 2002....
- Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learningK P Giese
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Science 279:870-3. 1998..Thus, the autophosphorylation of alphaCaMKII at Thr286 appears to be required for LTP and learning...
- Characterization of a calmodulin kinase II inhibitor protein in brainB H Chang
Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
Proc Natl Acad Sci U S A 95:10890-5. 1998..These results characterize a potent and specific cellular inhibitor of CaM-KII that may have an important role in the physiological regulation of this key protein kinase...
- Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learningYpe Elgersma
Department of Neurobiology, Department of Psychiatry, Department of Psychology, Brain Research Institute, University of California, Los Angeles, CA 90095, USA
Neuron 36:493-505. 2002..Mimicking inhibitory phosphorylation dramatically decreased the association of CaMKII with the PSD and blocked both LTP and learning. These data demonstrate that inhibitory phosphorylation has a critical role in plasticity and learning...
- Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase IITara R Gaertner
Department of Neurobiology and Anatomy, University of Texas Medical School, 6431 Fannin Street, Houston, TX 77030, USA
J Biol Chem 279:12484-94. 2004..Simulations utilizing this data revealed that the measured differences in CaM binding affinities play a minor role in the autophosphorylation of the enzyme, which is largely dictated by the rate of autophosphorylation for each isoform...
- Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase IIJeong S Oh
Division of Biology 216 76, California Institute of Technology, Pasadena, California 91125, USA
J Biol Chem 279:17980-8. 2004..We used phosphosite-specific antibodies to show that, as predicted, phosphorylation of serines 765 and 1123 is increased in cultured cortical neurons after exposure of the neurons to the agonist N-methyl-d-aspartate...
- Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2BK Ulrich Bayer
Department of Pharmacology, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurosci 26:1164-74. 2006..This activity-dependent incorporation of CaMKII into postsynaptic sites may play a role in maturation and plasticity of synapses...
- alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progressionKaiyu Yuan
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Lab Invest 87:938-50. 2007..Our results suggest that CaMKII plays a critical role in the growth of osteosarcoma, and its inhibition could be an attractive therapeutic target to combat conventional high-grade osteosarcoma in children...
- A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilizationChunmei Wang
Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
J Biol Chem 283:11565-74. 2008....
- Regulation of the proteasome by neuronal activity and calcium/calmodulin-dependent protein kinase IIStevan N Djakovic
Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0347, USA
J Biol Chem 284:26655-65. 2009..Our data provide a novel mechanism whereby CaMKII may regulate the proteasome in neurons to facilitate remodeling of synaptic connections through protein degradation...
- Autophosphorylated CaMKIIalpha acts as a scaffold to recruit proteasomes to dendritic spinesBaris Bingol
The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
Cell 140:567-78. 2010..Our findings reveal a scaffolding role of postsynaptic CaMKIIalpha in activity-dependent proteasome redistribution, which is commensurate with the great abundance of CaMKIIalpha in synapses...
- Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase IIJ S Moyers
Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 272:11832-9. 1997..Thus, the Rad family of GTP-binding proteins possess unique characteristics of binding CaM and calmodulin-dependent protein kinase II, suggesting a role for Rad-like GTPases in calcium activation of serine/threonine kinase cascades...
- Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5F Liu
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
Neuroscience 115:829-37. 2002..The combined impact of this modulation may be to make tau more susceptible to becoming abnormally hyperphosphorylated...
- Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stressMarianne B Muller
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, Munich 80804, Germany
Nat Neurosci 6:1100-7. 2003..from those that regulate neuroendocrine function, we generated a conditional knockout mouse line (Crhr1(loxP/loxP)Camk2a-cre) in which Crhr1 function is inactivated postnatally in anterior forebrain and limbic brain structures, but not ..
- Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptorR V Omkumar
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
J Biol Chem 271:31670-8. 1996..We show that serine 1303 in the full-length NR2B and/or the cognate site in NR2A is a major site of phosphorylation of the receptor both in the postsynaptic density fraction and in living hippocampal neurons...
- MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivoO Heidenreich
Institut fur Zellbiologie, Abteilung Molekularbiologie, Universitat Tubingen, D 72076 Tubingen, Germany
J Biol Chem 274:14434-43. 1999..These results demonstrate that SRF is targeted by several signal transduction pathways within cells and establishes SRF as a nuclear target for MAPKAP kinase 2...
- Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding proteinX Wu
Department of Molecular Pharmacology and Experimental Therapeutics, the Mayo Graduate School, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Biol Chem 276:1735-41. 2001..Thus, CamKII confers a dominant inhibitory effect on transcription by preventing dimerization of CREB, and this mechanism may account for the attenuation of gene expression...
- A Method to Identify p62's UBA Domain Interacting ProteinsJulia W Pridgeon
Department of Biological Sciences, Program in Cellular and Molecular Biosciences 331 Funchess Hall, Auburn University, Auburn, AL 36849 USA
Biol Proced Online 5:228-237. 2003..Our approach provides an easy route to the characterization of UBA domain interacting proteins and its application will unfold the important roles that the UBA domain plays...
- Behavioural studies using temporal and spatial inactivation of the oxytocin receptorHeon Jin Lee
Section on Neural Gene Expression, National Institute of Mental Health, National Institutes of Health, DHHS, Bethesda, MD, USA
Prog Brain Res 170:73-7. 2008..The latter was achieved by crossing the conditional Oxtr line with a transgenic line in which the Camk2a promoter drives expression of Cre recombinase to significant levels beginning 21-28 days after birth, thus ..
- Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine modelAaron N Long
Research Service, VAMHCS, 10 North Greene Street, Baltimore, MD, 21201, USA
BMC Neurol 15:19. 2015..To examine changes in mitochondrial morphology, bigenic mice possessing a fluorescent protein targeted to neuronal mitochondria (CaMK2a-mito/eYFP), were administered NMN.
- Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alphaD Bouvard
Faculte de Medecine de Grenoble, UMR CNRS UJF 5538, and, La Tronche Cedex, F38706, France
Biochem Biophys Res Commun 252:46-50. 1998..Conversely, the mutation T38A produces an analog of ICAP-1alpha that cannot be phosphorylated and that stimulates cell spreading on fibronectin to a similar extent when CaMKII is inhibited...
- Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failureJulie Bossuyt
Department of Physiology, Loyola University Chicago, Maywood, IL 60153, USA
Circ Res 102:695-702. 2008..This may directly contribute to the development and/or maintenance of HF...
- X11-like protein deficiency is associated with impaired conflict resolution in miceYoshitake Sano
Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
J Neurosci 29:5884-96. 2009..ethological responses and social behaviors in X11L-KO mice were rescued by the expression of X11L under a Camk2a promoter using the Tet-OFF system during development...
- Dual DNA methylation patterns in the CNS reveal developmentally poised chromatin and monoallelic expression of critical genesJinhui Wang
Division of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, United States of America
PLoS ONE 5:e13843. 2010..Three of the genes, Camk2a, Kcnc4, and Unc5a, show preferential expression of the same allele in all clonal NSC lines tested...
- Ventral hippocampal molecular pathways and impaired neurogenesis associated with 5-HT₁A and 5-HT₁B receptors disruption in miceLin Xia
Univ Paris Sud, EA3544, Faculte de Pharmacie, Chatenay Malabry F 92296, France
Neurosci Lett 521:20-5. 2012..and function, especially genes associated with long-term potentiation and adult neurogenesis (including Bdnf, Camk2a, Camk4, and Klf9)...
- DNA microarray and miRNA analyses reinforce the classification of follicular thyroid tumorsCaroline Jacques
Institut National de la Santé et de la Recherche Médicale U694, rue des Capucins, F 49033 Angers, France
J Clin Endocrinol Metab 98:E981-9. 2013..Focusing on mitochondrial function and thyroid tumorigenesis, we used an integrative approach to identify relevant biomarkers for borderline thyroid lesions...
- Large deletions encompassing the TCOF1 and CAMK2A genes are responsible for Treacher Collins syndrome with intellectual disabilityMarie Vincent
Departement de Genetique Medicale, CHRU Montpellier, Faculté de Médecine de Montpellier Mimes, Universite Montpellier 1, Montpellier, France
Eur J Hum Genet 22:52-6. 2014..We discuss the involvement of the other deleted genes such as CAMK2A or SLC6A7 in the cognitive development delay of the patients reported, and we propose the systematic investigation ..
- Reelin signaling pathway genotypes and Alzheimer disease in a Spanish populationEnric Bufill
Departments of Neurology Clinical Epidemiology and Research, Vic General Hospital, Vic Departments of Neurology Cardiology Epidemiology and Public Health, Hospital de la Santa Creu i Sant Pau, Barcelona Bernades Geriatric Center, Manresa, Spain
Alzheimer Dis Assoc Disord 29:169-72. 2015..This led us to ask whether genetic variability in the reelin pathway may increase the risk of developing Alzheimer disease (AD) or mild cognitive impairment (MCI)...
- Loss of aPKCλ in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brainsTomoyuki Yamanaka
Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Saitama, Japan Department of Neuroscience for Neurodegenerative Disorders, Juntendo University Graduate School of Medicine, Tokyo, Japan
PLoS ONE 8:e84036. 2013..performed conditional deletion of aPKCλ, a major aPKC isoform in the brain, in differentiated neurons of mice by camk2a-cre or synapsinI-cre mediated gene targeting...
- Gene expression profiles of patients with cerebral hematoma following spontaneous intracerebral hemorrhageTao Yang
Department of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan 610083, P R China
Mol Med Rep 10:1671-8. 2014..calcium channel, voltage‑dependent, T-type, α1I subunit, Ca2+/calmodulin‑dependent protein kinase II α (CAMK2A), ryanodine receptor 2 (RYR2) and inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1)], cell proliferation (..
- An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic miceAdam K Walker
Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research and
Hum Mol Genet 24:7241-54. 2015..Here, we developed transgenic (Tg) mice with forebrain Camk2a-controlled doxycycline-suppressible expression of a TDP-43 CTF (amino acids 208-414, designated 208 TDP-43 CTF), ..
- A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18M J Justice
Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
Genomics 13:1281-8. 1992..The Apc, Camk2a, D18Fcr1, D18Fcr2, D18Leh1, D18Leh2, Dcc, Emb-rs3, Fgfa, Fim-2/Csfmr, Gnal, Grl-1, Grp, Hk-1rs1, Ii, Kns, Lmnb, ..
- Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinaseT Toyofuku
Banting and Best Department of Medical Research, University of Toronto, C H Best Institute, Ontario, Canada
J Biol Chem 269:26492-6. 1994..Thus phosphorylation of Ser38 in SERCA2 results in a unique activation of Vmax for Ca2+ transport, providing a potential regulatory mechanism for Ca2+ removal from cardiac and other tissues in which SERCA2 is expressed...
- The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinaseH K Paudel
Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada
J Biol Chem 272:1777-85. 1997..Taken together, these results suggest that in neurons, phosphorylase kinase may be one of the kinases that participate in the phosphorylation of tau...
- Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complexF Gardoni
Institute of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
J Biol Chem 276:7609-13. 2001..Thus, our data provide clues on understanding the molecular basis of a direct cross-talk between alphaCaMKII and PKC pathways in the postsynaptic compartment...
- Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actininR S Walikonis
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
J Neurosci 21:423-33. 2001....
- Inositol 1,4,5-trisphosphate 3-kinase A associates with F-actin and dendritic spines via its N terminusM J Schell
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, United Kingdom
J Biol Chem 276:37537-46. 2001..The phosphorylation of IP(3) in dendritic spines to produce IP(4) is likely to be important for modulating the compartmentalization of calcium at synapses...
- Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1Hebin Liu
Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
Mol Biol Cell 13:4497-507. 2002..In addition, the Ca(2+)-dependent phosphorylation of Ets1 reduces the binding of Ets1 to the GM-CSF promoter in vivo...
- Regulation of Ca2+/calmodulin kinase II inhibitor alpha (CaMKIINalpha) in virus-infected mouse brainSougata Saha
Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India
Biochem Biophys Res Commun 350:444-9. 2006The alpha and beta isoforms of rat Ca(2+)/calmodulin kinase II inhibitor (CaMKIINalpha/beta) expressed in brain or brain and testis, respectively, are potent inhibitors of Ca(2+)/calmodulin kinase II (CaMKII) in vitro...
- Gene expression profiling on sheep brain reveals differential transcripts in scrapie-affected/not-affected animalsGian Mario Cosseddu
Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanita, Rome, Italy
Brain Res 1142:217-22. 2007..These bands were cloned and sequenced, allowing identifying the genes COX1, CHN1, PPP2CA, LRFN5, CAMK2A and RABEPK...
- Gene regulation in the frontal cortex of rats exposed to the chronic mild stress paradigm, an animal model of human depressionM Orsetti
Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche DiSCAFF Università del Piemonte Orientale A Avogadro, Via Bovio 6, 28100 Novara, Italy
Eur J Neurosci 27:2156-64. 2008..The results confirmed the downregulation of Itga6, Camk2a, Plcb1, Cart, Gad1, Homer1 and Th and the upregulation of Egr2 and Ptgs2 observed in the DNA microarray analysis...
- Rapid encoding of new information alters the profile of plasticity-related mRNA transcripts in the hippocampal CA3 regionRebecca P Haberman
Department of Psychological and Brain Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218, USA
Proc Natl Acad Sci U S A 105:10601-6. 2008..From a multitude of expression changes, increases in camk2a, rasgrp1, and nlgn1 were confirmed by in situ hybridization...
- Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BBHye Won Shin
Department of Pathology, Seoul National University College of Medicine, Korea
Korean J Hepatol 15:486-95. 2009..This study aimed to better understand gene expression profiles of human hepatic stellate cell (HSC) activation and the relationship with the Wnt signaling pathway...
- Large T-antigen up-regulates Kv4.3 K⁺ channels through Sp1, and Kv4.3 K⁺ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase IIQi Li
Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin 150086, People s Republic of China
Biochem J 441:859-67. 2012..3 K⁺ channels contribute to cell apoptosis and necrosis through activating CaMKII. The present study provides deep insights into the mechanism of the regulation of Kv4.3 K⁺ channels and the role of Kv4.3 K⁺ channels in cell death...
- Activity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIαRobyn Flynn
Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
PLoS ONE 7:e41185. 2012..Rem2 is the only RGK protein found predominantly in the brain, where it has been linked to synaptic development. We wished to determine the effect of neuronal activity on the subcellular distribution of Rem2 and its interacting partners...
- Calmodulin-dependent kinase II regulates osteoblast differentiation through regulation of OsterixYou Hee Choi
College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500 757, Republic of Korea
Biochem Biophys Res Commun 432:248-55. 2013..These results suggest that Osterix is a novel target of CaMKII and the activity of Osterix can be modulated by a novel mechanism involving CaMKII during osteoblast differentiation...
- αCaMKII autophosphorylation controls the establishment of alcohol drinking behaviorAlanna C Easton
MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, London, UK
Neuropsychopharmacology 38:1636-47. 2013..to compare findings in mice with the human condition, we tested 23 single-nucleotide polymorphisms (SNPs) in the CAMK2A gene for their association with alcohol dependence in a population of 1333 male patients with severe alcohol ..
- The early molecular processes underlying the neurological manifestations of an animal model of Wilson's diseaseBeom Hee Lee
Department of Pediatrics, Asan Medical Center Children s Hospital, University of Ulsan College of Medicine, Seoul, Korea
Metallomics 5:532-40. 2013..to mitochondrial respiration (Sdhaf2 and Ndufb7), calcineurin-mediated cellular processes (Ppp3ca, Ppp3cb, and Camk2a), amyloid precursor protein (Anks1b and A2m) and alpha-synuclein (Snca)...
- Electroconvulsive seizure-induced changes in gene expression in the mouse hypothalamic paraventricular nucleusMari Sakaida
1Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
J Psychopharmacol 27:1058-69. 2013..The groups of downregulated genes included neuropeptides (Cck), kinases (Prkcb, Camk2a), transcription factors (Tcf4), and transporters (Aqp4), and these have been suggested to be associated with ..
- CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic densitySoe Thein
Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 9:e91312. 2014....
- Membrane actions of 1α,25(OH)2D3 are mediated by Ca(2+)/calmodulin-dependent protein kinase II in bone and cartilage cellsMaryam Doroudi
School of Biology, Georgia Institute of Technology, 310 Ferst Drive NW, Atlanta, GA 30332, USA
J Steroid Biochem Mol Biol 145:65-74. 2015..b>Camk2a-silenced but not Camk2b-silenced osteoblasts showed comparable effects...
- The involvement of Nek2 and Notch in the proliferation of rat adrenal cortex triggered by POMC-derived peptidesPedro Omori Ribeiro de Mendonça
Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
PLoS ONE 9:e108657. 2014..In the current study, the inhibition of the HPA axis repressed the expression of Ccnb2, Camk2a, and Nek2 genes throughout the adrenal cortex, while treatments with POMC-derived peptides stimulated Nek2, gene ..
- A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in miceGéraldine M Mang
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
PLoS ONE 10:e0116760. 2015..b>Camk2a-CreERT2 (Cre+) and floxed Dicer (Dicerlox/lox) mice were crossed to generate tamoxifen-inducible conditional Dicer ..
- Rare variants in neuronal excitability genes influence risk for bipolar disorderSeth A Ament
Institute for Systems Biology, Seattle, WA 98109
Proc Natl Acad Sci U S A 112:3576-81. 2015..3,014 cases and 1,717 controls confirmed rare variant associations in ANK3, CACNA1B, CACNA1C, CACNA1D, CACNG2, CAMK2A, and NGF...
- Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine modelAaron N Long
Research Service, VAMHCS, 10 North Greene Street, Baltimore, MD, 21201, USA
BMC Neurol 15:272. 2015..To examine changes in mitochondrial morphology, bigenic mice possessing a fluorescent protein targeted to neuronal mitochondria (CaMK2a-mito/eYFP), were administered NMN.
- Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathwaysJ L Meyers
Department of Epidemiology, Columbia University, New York, NY, USA
Transl Psychiatry 5:e586. 2015..variants across the mGluR-eEF2-AMPAR pathway (including GRM1, GRM5, HOMER1, HOMER2, EEF2K, MTOR, EIF4E, EEF2, CAMK2A, ARC, GRIA1 and GRIA4) were found to predict number of drinking days per month (corrected P-value < 0...
- A retrograde adeno-associated virus for collecting ribosome-bound mRNA from anatomically defined projection neuronsDenise R Cook-Snyder
Department of Neuroscience, School of Medicine, Tufts University Boston, MA, USA Department of Biology and Neuroscience Program, Carthage College Kenosha, WI, USA
Front Mol Neurosci 8:56. 2015..3 kb alpha-calcium/calmodulin-dependent protein kinase II (Camk2a) promoter...
- Involvement of Ca(2+)-Dependent Hyperpolarization in Sleep Duration in MammalsFumiya Tatsuki
Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Neuron 90:70-85. 2016..Kcnn2 and Kcnn3), voltage-gated Ca(2+) channels (Cacna1g and Cacna1h), or Ca(2+)/calmodulin-dependent kinases (Camk2a and Camk2b) decrease sleep duration, while impaired plasma membrane Ca(2+) ATPase (Atp2b3) increases sleep ..
- Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse ModelHideo Hagihara
Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Agency JST, Kawaguchi, Saitama 332 0012, Japan
Cell Rep 14:2784-96. 2016..Here, we use infradian (longer than a day) cyclic activity levels in αCaMKII (Camk2a) mutant mice as a proxy for such mood-associated changes...
- High-resolution chromosome ideogram representation of recognized genes for bipolar disorderLindsay N Douglas
Department of Psychiatry and Behavioral Sciences and Pediatrics, University of Kansas Medical Center, Kansas City, KS 66160, USA
Gene 586:136-47. 2016..g., CACNA1C, CAMK2A, CAMK2D, ADCY1, ADCY2); glutamatergic (e.g., GRIK1, GRM3, GRM7), dopaminergic (e.g...
- Molecular triggers of egg activation at fertilization in mammalsJessica R Sanders
School of MedicineCardiff University, Cardiff, UK
Reproduction 152:R41-50. 2016..The main downstream target of Ca(2+) i oscillations is calmodulin-dependent protein kinase II (CAMKII (CAMK2A)), which phosphorylates EMI2 and WEE1B to inactivate the M-phase promoting factor protein kinase activity (MPF) ..
- Iron Deficiency Impairs Developing Hippocampal Neuron Gene Expression, Energy Metabolism, and Dendrite ComplexityThomas W Bastian
Department of Pediatrics and Center for Neurobehavioral Development, School of Medicine, Minneapolis, Minn, USA
Dev Neurosci 38:264-276. 2016..DFO treatment decreased mRNA levels for genes indexing dendritic and synaptic development (i.e. BdnfVI,Camk2a,Vamp1,Psd95,Cfl1, Pfn1,Pfn2, and Gda) and mitochondrial function (i.e. Ucp2,Pink1, and Cox6a1)...
- In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbensR M Bastle
School of Life Sciences, Arizona State University, Tempe, AZ, USA
Mol Psychiatry . 2017..Using luciferase reporter assays, we found that miR-495 directly targeted the 3'UTRs of Bdnf, Camk2a and Arc...
- Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosisB Inbal
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
Mol Cell Biol 20:1044-54. 2000..Possible functional connections between DAP kinase and DRP-1 are discussed...
- NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: inhibition by HIV-1 Tat C-terminal domainAlessandro Poggi
Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy
J Immunol 168:95-101. 2002..These data provide evidence that exogenous Tat inhibits NK cell activation occurring upon contact with DC: this mechanism might contribute to the impairment of natural immunity in HIV-1 infection...
- Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activationMaddalena Illario
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli, 80131 Italy
J Biol Chem 278:45101-8. 2003..These findings also provide evidence supporting the possible existence of cross-talk between other intracellular pathways involving CaMKII and Raf-1...
- A reassessment of the inhibitory capacity of human FKBP38 on calcineurinMatthias Weiwad
Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, D 06120 Halle Saale, Germany
FEBS Lett 579:1591-6. 2005..Our data suggest that hFKBP38 cannot substitute for the FKBP/FK506 complex in signaling pathways controlled by the protein phosphatase activity of calcineurin...
- A microfluidic culture platform for CNS axonal injury, regeneration and transportAnne M Taylor
Department of Biomedical Engineering, University of California, Irvine, 204 Rockwell Engineering, Irvine, California 92697, USA
Nat Methods 2:599-605. 2005..We report the first evidence that presynaptic (Syp) but not postsynaptic (Camk2a) mRNA is localized to developing rat cortical and hippocampal axons...
- An endogenous inhibitor of calcium/calmodulin-dependent kinase II is up-regulated during consolidation of fear memoryEve M Lepicard
Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK
Eur J Neurosci 23:3063-70. 2006b>CaMKIINalpha and CaMKIINbeta are endogenous inhibitors of the abundant synaptic protein, calcium/calmodulin-dependent protein kinase II (CaMKII)...
- IL-10 regulation by HIV-Tat in primary human monocytic cells: involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 MAPK and Sp-1 and CREB-1 transcription factorsKatrina Gee
Department of Pathology and Laboratory Medicine, Division of Virology and Molecular Immunology, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, Canada
J Immunol 178:798-807. 2007..Taken together, our results suggest that extracellular HIV-Tat induced IL-10 transcription in primary human monocytes is regulated by CREB-1 and Sp-1 transcription factors through the activation of calmodulin/CaMK-II-dependent p38 MAPK...
- HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND)Zainulabedin M Saiyed
Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA
Neurochem Int 58:656-64. 2011..Therefore, use of HDAC2 specific inhibitor in combination with HAART may be of therapeutic value in treatment of neurocognitive disorders observed in HIV-1 infected individuals...
- Substrate-selective and calcium-independent activation of CaMKII by α-actininNidhi Jalan-Sakrikar
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 287:15275-83. 2012..These data show that Ca(2+)-independent binding of α-actinin to CaMKII differentially modulates the phosphorylation of physiological targets that play key roles in long-term synaptic plasticity...
- The role of CaMKII in regulating GLUT4 expression in skeletal muscleEdward O Ojuka
University of Capetown Medical Research Center Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Univeristy of Cape Town, Cape Town, South Africa
Am J Physiol Endocrinol Metab 303:E322-31. 2012..Finally, an appraisal of the roles of other calcium- and non-calcium-dependent mechanisms, including the major HDAC kinases in GLUT4 expression, is also given...
- Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neuronsStevan N Djakovic
Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 32:5126-31. 2012..Together, these data suggest that CaMKII-dependent phosphorylation of Rpt6 at S120 may be an important regulatory mechanism for proteasome-dependent control of synaptic remodeling in slow homeostatic plasticity...
- AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine rewardSaid Kourrich
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
J Neurosci 32:6578-86. 2012..This study identifies CaMKII regulation of IA in NAc shell neurons as a novel cellular contributor to the sensitization of cocaine reward...
- Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95Nien Pei Tsai
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell 151:1581-94. 2012..Together, our findings reveal roles for multiple autism-linked genes in activity-dependent synapse elimination...
- NMDA receptor hypofunction induces dysfunctions of energy metabolism and semaphorin signaling in rats: a synaptic proteome studyKejun Zhou
Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China
Schizophr Bull 38:579-91. 2012..Using western blots, we confirmed the differential expression of Camk2a, Crmp2, Crmp5, Dnm1, and Ndufs3 in both synaptosome proteins and total proteins in the cerebral cortex of the rats...
- Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loadingDaniel Johnstone
School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, Australia
Brain Res 1448:144-52. 2012..Grin1, GABA receptor Gabbr1) and synaptic plasticity and memory (calcium/calmodulin-dependent protein kinase IIα Camk2a)...
- Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinaseJ L Countaway
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605
J Biol Chem 267:1129-40. 1992..This regulatory phosphorylation site is located at the carboxyl terminus of the EGF receptor within the subdomain that binds src homology 2 regions of signaling molecules...
- Calcium-regulated phosphorylation within the leucine zipper of C/EBP betaM Wegner
Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648
Science 256:370-3. 1992..Phosphorylation of serine at position 276 within the leucine zipper of C/EBP beta appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBP beta...
- PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18M B Omary
Stanford University School of Medicine, Gastroenterology Division, California 94305
J Cell Biol 117:583-93. 1992..We propose that a kinase related to the catalytic fragment of PKC epsilon physically associates with and phosphorylates cytokeratins 8 and 18...
- Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sitesD S Bredt
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
J Biol Chem 267:10976-81. 1992..We demonstrate that purified NOS is labeled by a photoaffinity derivative of calmodulin. These recognition sites on NOS provide multiple means for regulation of NO levels and "cross-talk" between second messenger systems...
- Ca2(+)-calmodulin-dependent protein kinase II phosphorylates various types of non-epithelial intermediate filament proteinsT Tokui
Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Japan
Biochem Biophys Res Commun 169:896-904. 1990..The actions of Ca2(+)-CaM-dependent protein kinase II on non-epithelial intermediate filaments under physiological conditions are given attention...
- Phosphorylation sites linked to glial filament disassembly in vitro locate in a non-alpha-helical head domainM Inagaki
Laboratory of Experimental Radiology, Aichi Cancer Center Research Institute, Japan
J Biol Chem 265:4722-9. 1990..All the sites are located within the amino-terminal non-alpha-helical head domain of GFAP. These observations pave the way for in vivo studies on organization of glial filaments...
- Ca2+/calmodulin-dependent protein kinase II: localization in the interphase nucleus and the mitotic apparatus of mammalian cellsY Ohta
Department of Pharmacology, Kumamoto University Medical School, Japan
Proc Natl Acad Sci U S A 87:5341-5. 1990..The localization of CaM kinase II in the cell nucleus and the mitotic apparatus suggests that the enzyme may play a role in the cell cycle progression of mammalian cells...
- Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262G Drewes
Max Planck Unit for Structural Molecular Biology, Hamburg, Federal Republic of Germany
J Biol Chem 270:7679-88. 1995..The data suggest a role for this novel kinase in cellular events involving rearrangement of the microtuble-associated proteins/microtubule arrays and their pathological degeneration in Alzheimer's disease...
- Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding proteinA Shimomura
Department of Anatomy, Nagoya University School of Medicine, Japan
J Biol Chem 271:17957-60. 1996..As expected from these in vitro studies, transient transfection studies revealed that ATF1 is activated by CaMK II. Our findings suggest that CaMK II mediates transactivation of cAMP responsive genes via ATF1...
- Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestationD L Andersen
Royal Brisbane Hospital Research Foundation, Australia
Brain Res Dev Brain Res 88:178-85. 1995..The evidence suggests that Glutamate-NMDA binding sites may undergo structural rearrangements which alter their ability to interact with ligands during the later stages of human gestation, and that such changes are regionally variable...
- Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+L P Wollmuth
Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
J Physiol 506:13-32. 1998..The contribution to the blocking site, in contrast to the prevailing view, is stronger for the N + 1 site than for the N-site asparagine. The block may involve binding of Mg2+ to these residues...
- Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubulesA Sengupta
New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
Arch Biochem Biophys 357:299-309. 1998..Together, our results indicate that the binding of tau to microtubules is controlled by the phosphorylation of several sites, among which are Thr 231, Ser 235, and Ser 262...
- Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinaseJ Z Wang
Chemical Neuropathology Department, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
FEBS Lett 436:28-34. 1998..Thus a combined role of A-kinase and GSK-3 should be considered in Alzheimer neurofibrillary degeneration...
- Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generationR L Feinmesser
Department of Cancer Medicine, Imperial College School of Medicine, Charing Cross Campus, Fulham Palace Road, London W6 8RP, United Kingdom
J Biol Chem 274:16168-73. 1999....
- Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of RafP H Anborgh
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892, USA
Mol Cell Biol 19:4611-22. 1999....
- Regulation of neuronal nitric-oxide synthase by calmodulin kinasesY Hayashi
Department of Pharmacology, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
J Biol Chem 274:20597-602. 1999..Using the antibody NP847, we obtained evidence that nNOS is phosphorylated at Ser847 in rat brain. Thus, our results suggest that CaM kinase-induced phosphorylation of nNOS at Ser847 alters the activity control of this enzyme...
- Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sitesM Fluck
Department of Integrative Biology and Pharmacology, University of Texas Medical School, Houston, Texas 77030, USA
Biochem Biophys Res Commun 270:488-94. 2000..The location of Thr-160 in the 3-D structure of SRF suggests that its phosphorylation by nuclear CaMKII may directly influence DNA binding of SRF and other MADS box factors...
- CaM-kinases: modulators of synaptic plasticityT R Soderling
Vollum Institute, L 474 Oregon Health Sciences University, Portland, OR 97201, USA
Curr Opin Neurobiol 10:375-80. 2000..More prolonged responses may be effected through enhanced dendritic protein synthesis of CaM-KII and regulation of nuclear gene transcription by CaM-KIV...
- Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase IIS J Wicks
Department of Cancer Medicine, Division of Medicine, Imperial College School of Medicine, Hammersmith Campus, London W12 ONN, United Kingdom
Mol Cell Biol 20:8103-11. 2000..These findings provide a novel cross-talk mechanism by which Ca(2+)-dependent kinases activated downstream of multiple growth factor receptors antagonize cell responses to TGF-beta...
- Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brainLara Fallon
Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
J Biol Chem 277:486-91. 2002..These data implicate for the first time a PDZ-mediated interaction between parkin and CASK in neurodegeneration and possibly in ubiquitination of proteins involved in synaptic transmission and plasticity...
- Molecular cloning and sequence analyses of calcium/calmodulin-dependent protein kinase II from fetal and adult human brain. Sequence analyses of human brain calciuum/calmodulin-dependent protein kinase IIG Li
Department of Anatomical Sciences and Neurobiology University of Louisville School of Medicine, KY 40202, USA
Mol Biol Rep 28:35-41. 2001..The CaMKII alpha, alphaB, beta, beta' and beta(e) isoforms were characterized in both human fetal and adult brain...
- Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]Sulaiman Sheriff
Department of Surgery, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
Peptides 23:87-96. 2002..These findings suggest that the NPY Y(1) receptor induces the expression of CRE containing target genes through the CaM kinase-CREB pathway, and inhibits CRE containing genes when cellular cAMP levels are elevated...
- XIANJIN ZHOU; Fiscal Year: 2014..Sp4- NMDAR1 expression will be restored in CA1 by crossing CamK2a-Cre and Sp4 hypomorphic mice...
- MRI Assessment of Hippocampal Volume and Function in a Mouse Model of PTSDGregory G Brown; Fiscal Year: 2013..group, longitudinal design, 24 transgenic mice that transiently over-express CRF when treated with doxycycline (Camk2a-rTta2 "dox-on" system combined with tet-o-CRF transgene) will be compared with 24 untreated mice at baseline, ..
- Spatial and temporal control of the mouse genome by lacHeidi Scrable; Fiscal Year: 2005..the LaclR coding sequences into the beta-actin (universal expression), protamine (testis-specific expression), and Camk2a (adult forebrain-specific expression) genes...
- Cell-permeable inibitors specific for CaMKIIK Ulrich Bayer; Fiscal Year: 2006..The inhibitor developed and characterized in this proposal will allow easy testing of specific CaMKII functions in various physiological and pathological situations, and may thus lead to new therapeutic avenues, including for stroke. ..
- CaMKII signaling in insulin secretion and responseK Ulrich Bayer; Fiscal Year: 2007..3) Test feasibility of methods to study function of specific CaMKII isoforms in beta cells and islets. [unreadable] [unreadable]..
- Calmodulin-dependent kinases regulate neuronal developmentThomas R Soderling; Fiscal Year: 2010..Thus, these studies have strong implications for underlying causes of mental diseases. ..