Genomes and Genes
Gene Symbol: calsequestrin
Description: calsequestrin 1
Alias: CASQ, PDIB1, VMCQA, calsequestrin-1, calmitin, calmitine, calsequestrin 1 (fast-twitch, skeletal muscle), calsequestrin, skeletal muscle isoform
Publications104 found, 100 shown here
- Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order AmishMao Fu
Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Diabetes 53:3292-9. 2004b>Calsequestrin (CASQ)1 is involved in intracellular storage and release of calcium, a process that has been shown to mediate glucose transport in muscle...
- Identification of calcium binding sites on calsequestrin 1 and their implications for polymerizationAmit Kumar
CRS4, Bioengineering Group, Science and Technology Park Polaris, Piscina Manna, 09010 Pula, CA, Italy
Mol Biosyst 9:1949-57. 2013Biophysical studies have shown that each molecule of calsequestrin 1 (CASQ1) can bind about 70-80 Ca(2+) ions. However, the nature of Ca(2+)-binding sites has not yet been fully characterized...
- Effectiveness of preventive family intervention in improving cognitive attributions among children of depressed parents: a randomized studyRaija Leena Punamaki
School of Social Sciences and Humanities Psychology, University of Tampere, Tampere, Finland
J Fam Psychol 27:683-90. 2013..Children reported their cognitive attributions (CASQ-R, Children's Attributional Style Questionnaire-Revised (Thompson, Kaslow, Weiss, & Nolen-Hoeksema, 1998)), ..
- Endogenous and maximal sarcoplasmic reticulum calcium content and calsequestrin expression in type I and type II human skeletal muscle fibresC R Lamboley
G D Lamb Department of Zoology, La Trobe University, Melbourne, Victoria 3086, Australia
J Physiol 591:6053-68. 2013The relationship between sarcoplasmic reticulum (SR) Ca(2+) content and calsequestrin (CSQ) isoforms was investigated in human skeletal muscle...
- A mutation in the CASQ1 gene causes a vacuolar myopathy with accumulation of sarcoplasmic reticulum protein aggregatesDaniela Rossi
Molecular Medicine Section, Department of Molecular and Developmental Medicine, University of Siena and Azienda Ospedaliera Universitaria Senese, Siena, 53100, Italy IIM, Interuniversity Institute of Myology
Hum Mutat 35:1163-70. 2014A missense mutation in the calsequestrin-1 gene (CASQ1) was found in a group of patients with a myopathy characterized by weakness, fatigue, and the presence of large vacuoles containing characteristic inclusions resulting from the ..
- Calsequestrins in skeletal and cardiac muscle from adult Danio rerioSandra Furlan
Institute of Neuroscience Consiglio Nazionale delle Ricerche, Viale G Colombo 3, 35121, Padua, Italy
J Muscle Res Cell Motil 37:27-39. 2016b>Calsequestrin (Casq) is a high capacity, low affinity Ca(2+)-binding protein, critical for Ca(2+)-buffering in cardiac and skeletal muscle sarcoplasmic reticulum. All vertebrates have multiple genes encoding for different Casq isoforms...
- Design Principles of Reptilian Muscles: Calcium Cycling StrategiesStefano Perni
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania
Anat Rec (Hoboken) 299:352-60. 2016..Morphometric analysis demonstrates a pattern of increasing calsequestrin (CASQ) content in the lumen of SR from turtle to lizard, watersnake, and boa constrictor, and this content is ..
- Cancer Appetite and Symptom Questionnaire (CASQ) for Brazilian Patients: Cross-Cultural Adaptation and Validation StudyMaria Cláudia Bernardes Spexoto
Departamento de Alimentos e Nutrição, Faculdade de Ciências Farmacêuticas de Araraquara UNESP Univ Estadual Paulista, Rod Araraqura Jaú, km 01, Araraquara, Sao Paulo, Brazil
PLoS ONE 11:e0156288. 2016..This study aimed to perform a cultural adaptation of the Cancer Appetite and Symptom Questionnaire (CASQ), into Portuguese and evaluate its psychometric properties on a sample of Brazilian cancer patients.
- The effect of taurine and β-alanine supplementation on taurine transporter protein and fatigue resistance in skeletal muscle from mdx miceDeanna M Horvath
Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, Vic, 3086, Australia
Amino Acids 48:2635-2645. 2016..1 (RyR1), dihydropyridine receptor (DHPR), sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA1) or calsequestrin 1 (CSQ1)] between WT and mdx mice, and the expression of these proteins was not altered by taurine or β-..
- An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhoodHaroon I Sheikh
University of Western Ontario
Pers Individ Dif 45:425-428. 2008..completed a self-report measure of attributional styles, the Child Attributional Style Questionnaire-Revised (CASQ-R)...
- Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout miceBarbara Mosca
Department of Experimental and Diagnostic Medicine, General Pathology Section, University of Ferrara, Via Borsari 46, Ferrara 44121, Italy
Nat Commun 4:1541. 2013..JP45 is a membrane protein interacting with Ca(v)1.1 and the sarcoplasmic reticulum Ca(2+) storage protein calsequestrin (CASQ1). Here we show that JP45 and CASQ1 strengthen skeletal muscle contraction by modulating Ca(v)1...
- Dysferlin interacts with calsequestrin-1, myomesin-2 and dynein in human skeletal muscleBàrbara Flix
Servei de Neurologia, Laboratori de Neurologia Experimental, Hospital de la Santa Creu i Sant Pau i Institut de Recerca de HSCSP, Barcelona, Spain
Int J Biochem Cell Biol 45:1927-38. 2013..imaging showed a direct interaction of dysferlin with Trim72/MG53, AHNAK, cytoplasmic dynein, myomesin-2 and calsequestrin-1, but not with caveolin-3 or dystrophin...
- Isobaric Tagging-Based Quantification for Proteomic Analysis: A Comparative Study of Spared and Affected Muscles from mdx Mice at the Early Phase of DystrophyCintia Yuri Matsumura
Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
PLoS ONE 8:e65831. 2013..The calcium-handling proteins sarcalumenin and calsequestrin-1 were increased in control EOM compared with control DIA, reinforcing the view that constitutional properties ..
- Distinct regions of triadin are required for targeting and retention at the junctional domain of the sarcoplasmic reticulumDaniela Rossi
Department of Molecular and Developmental Medicine, University of Siena, Via A Moro 2, 53100 Siena, Italy
Biochem J 458:407-17. 2014..multiprotein complex containing the RyR (ryanodine receptor) and additional proteins, including triadin and calsequestrin. The signals which drive these proteins to the j-SR and how they assemble to form this multiprotein complex ..
- Understanding the beneficial effects of doxycycline on the dystrophic phenotype of the mdx mouseJuliano Alves Pereira
Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, 13083 865, Brazil
Muscle Nerve 50:283-6. 2014..The purpose of this study was to better understand the beneficial effects of doxycycline on the dystrophic muscles of the mdx mouse...
- Differential skeletal muscle proteome of high- and low-active miceDavid P Ferguson
Children s Nutritional Research Center, Baylor College of Medicine, Houston, Texas
J Appl Physiol (1985) 116:1057-67. 2014..g., annexin A6, P = 0.0031; calsequestrin 1; P = 0...
- Resiliency training in Indian children: a pilot investigation of the Penn Resiliency ProgramAruna Sankaranarayanan
Director Prayatna 57, Prithvi Avenue, Chennai 600018, India
Int J Environ Res Public Health 11:4125-39. 2014..An Analysis of Covariance comparing post-test scores on Children's Attributional Style Questionnaire (CASQ) while controlling for baseline scores indicated that children in the intervention group exhibited a significant ..
- An association study of CASQ1 gene polymorphisms and heat strokeYing Li
Department of Radiology, Chinese PLA Medical School, Beijing 100853, China
Genomics Proteomics Bioinformatics 12:127-32. 2014..conditions have not yet been elucidated, a novel disease-associated gene encoding a calcium-binding protein, calsequestrin-1 (CASQ1), was suggested relevant based on results from a transgenic murine model...
- The C-terminal calcium-sensitive disordered motifs regulate isoform-specific polymerization characteristics of calsequestrinNaresh C Bal
Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, 43210
Biopolymers 103:15-22. 2015b>Calsequestrin (CASQ) exists as two distinct isoforms CASQ1 and CASQ2 in all vertebrates. Although the isoforms exhibit unique functional characteristic, the structural basis for the same is yet to be fully defined...
- The disorders of the calcium release unit of skeletal muscles: what have we learned from mouse models?Marta Canato
Department of Biomedical Sciences, Laboratory of Physiology, University of Padova, Via Marzolo 3, 35131, Padua, Italy
J Muscle Res Cell Motil 36:61-9. 2015..called Calcium Release Unit and composed of DiHydroPyridine Receptor or DHPR, Ryanodine Receptor or RYR, Calsequestrin or CASQ, junctin, Triadin, Junctophilin and Mitsugumin 29...
- Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden deathAntonio Michelucci
From the Center for Research on Ageing and Department of Neuroscience, Imaging and Clinical Sciences, University G d Annunzio of Chieti, Chieti, Italy A M, C P, L P, A D M, F P Department of Biomedical Sciences, University of Padova, Padova, Italy M C, C R and Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York L W L, R T D
Anesthesiology 123:603-17. 2015Mice lacking calsequestrin-1 (CASQ1-null), a Ca-binding protein that modulates the activity of Ca release in the skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia in humans when exposed to ..
- A CASQ1 founder mutation in three Italian families with protein aggregate myopathy and hyperCKaemiaClaudia Di Blasi
Neuromuscular Diseases and Neuroimmunology Unit, Foundation IRCCS Neurological Institute C Besta, Milano, Italy
J Med Genet 52:617-26. 2015..Familial idiopathic hyperCKaemia is a benign genetically heterogeneous condition with autosomal dominant features in a high proportion of cases...
- Characterization of Two Human Skeletal Calsequestrin Mutants Implicated in Malignant Hyperthermia and Vacuolar Aggregate MyopathyKevin M Lewis
From the Department of Chemistry, Washington State University, Pullman, Washington 99164 4630
J Biol Chem 290:28665-74. 2015b>Calsequestrin 1 is the principal Ca(2+) storage protein of the sarcoplasmic reticulum of skeletal muscle...
- Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal MusclesBarbara Mosca
Department of Life Science and Biotechnology, University of Ferrara, Via Borsari 46, 44100, Ferrara, Italy
J Biol Chem 291:14555-65. 2016We exploited a variety of mouse models to assess the roles of JP45-CASQ1 (CASQ, calsequestrin) and JP45-CASQ2 on calcium entry in slow twitch muscles...
- Characterization of Post-Translational Modifications to Calsequestrins of Cardiac and Skeletal MuscleKevin M Lewis
Department of Chemistry, Washington State University, Pullman, WA 99164, USA
Int J Mol Sci 17:. 2016b>Calsequestrin is glycosylated and phosphorylated during its transit to its final destination in the junctional sarcoplasmic reticulum...
- Sequencing of genes involved in the movement of calcium across human skeletal muscle sarcoplasmic reticulum: continuing the search for genes associated with malignant hyperthermiaA R Bjorksten
Senior Scientist, Malignant Hyperthermia Diagnostic Unit, Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Anaesthesia, Perioperative and Pain Medicine Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Victorian Clinical Genetics Service Molecular Genetics Laboratory, Murdoch Children s Research Institut
Anaesth Intensive Care 44:762-768. 2016..Nevertheless they provide the basis for a new set of functional studies, which may indeed identify novel players in MH...
- DNA Hypomethylation in Intragenic and Intergenic Enhancer Chromatin of Muscle-Specific Genes Usually Correlates with their ExpressionKenneth C Ehrlich
Program in Bioinformatics and Genomics, Tulane University Health Sciences Center, New Orleans, LA
Yale J Biol Med 89:441-455. 2016..Our study suggests that DNA hypomethylation increases enhancer tissue-specificity and that SkM super-enhancers sometimes are poised for physiologically important, rapid up-regulation...
- Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles onlyGiorgia Valle
Dipartimento di Scienze Biomediche dell Università di Padova, Istituto Interuniversitario di Miologia, Viale G Colombo 3, 35121, Padova, Italy
J Muscle Res Cell Motil . 2017..CASQ2-/- causes increase in calsequestrin 1 (CASQ1) expression, but without functional changes in both muscle types...
- Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin geneJ Fujii
Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada
Somat Cell Mol Genet 16:185-9. 1990A genomic clone encoding human fast-twitch skeletal muscle calsequestrin was isolated, and the amino acid sequence of the protein and the exon-intron boundaries of the gene were deduced from its sequence...
- Skeletal muscle of patients with Duchenne's muscular dystrophy: evidence of a mitochondrial proteolytic factor responsible for calmitine deficiencyB Lucas-Heron
Groupe de Recherche sur les Myopathies, Laboratoire de Physiologie, U E R de Médecine, Nantes, France
Biochem Biophys Res Commun 223:31-5. 1996..of mitochondrial extracts of skeletal muscle obtained from patients with Duchenne's muscular dystrophy (DMD) on calmitine of the mitochondrial matrix isolated from skeletal muscle of control mice...
- Linkage and radiation hybrid mapping of the porcine calsequestrin 1 (CASQ1 ) gene to chromosome 4qA Knoll
Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, 277 21 Libechov, Czech Republic
Anim Genet 33:390-2. 2002
- Clinically active serologically quiescent systemic lupus erythematosusDafna D Gladman
University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5 034, Toronto, Ontario, Canada M5T 2S8
J Rheumatol 30:1960-2. 2003To identify the frequency and characteristics of clinical activity with serological quiescence (CASQ) in a large cohort of patients with systemic lupus erythematosus (SLE) followed prospectively at a single center.
- Calsquestrin 1 (CASQ1) gene polymorphisms under chromosome 1q21 linkage peak are associated with type 2 diabetes in Northern European CaucasiansSwapan Kumar Das
Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Diabetes 53:3300-6. 2004..We identified two SNPs that showed strong associations, and both mapped to within intron 2 of the calsequestrin 1 (CASQ1) gene...
- Potential regulatory role of calsequestrin in platelet Ca(2+) homeostasis and its association with platelet hyperactivity in diabetes mellitusZ Zhu
Department of Pharmacology, Capital Medical University, Beijing, China
J Thromb Haemost 10:116-24. 2012Altered Ca(2+) homeostasis contributes significantly to platelet hyperactivity in diabetes mellitus. Calsequestrin (CSQ), as a Ca(2+) buffer protein in the sarcoplasmic reticulum, also regulates the Ca(2+) release process in muscles...
- High-capacity Ca2+ binding of human skeletal calsequestrinEmiliano J Sanchez
School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
J Biol Chem 287:11592-601. 2012b>Calsequestrin, the major calcium storage protein in both cardiac and skeletal muscle, binds large amounts of Ca(2+) in the sarcoplasmic reticulum and releases them during muscle contraction...
- Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast-twitch muscleAndres Hernandez
Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
J Physiol 590:3575-83. 2012..changes in nitrate treated mice were accompanied by increased expression of the Ca(2+) handling proteins calsequestrin 1 and the dihydropyridine receptor...
- Both short intense and prolonged moderate in vitro stimulation reduce the mRNA expression of calcium-regulatory proteins in rat skeletal muscleSatu Mänttäri
Department of Biology, University of Oulu, P O Box 3000, 90014 Oulu, Finland
Mol Cell Biochem 373:171-8. 2013..The mRNA level of Ca(2+)-ATPase (SERCA1, 2), calsequestrin (CASQ1, 2), ryanodine receptor (RyR1), and dihydropyridine receptor (Cacna1) was assessed in rat extensor ..
- Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscleCarlo Manno
Section of Cellular Signaling Department of Molecular Biophysics and Physiology, Rush University School of Medicine, 1750 W Harrison St, Chicago, IL 60612, USA
J Physiol 591:423-42. 2013..6). The difference suggests that 75% of the releasable calcium is normally bound to calsequestrin. In the nulls the difference in B between ON and OFF was less than in the WT but still significant...
- Molecular mechanisms of pharmaceutical drug binding into calsequestrinArun K Subra
Department of Chemistry, Washington State University, Pullman, WA 99164 4630, USA
Int J Mol Sci 13:14326-43. 2012b>Calsequestrin (CASQ) is a major Ca2+-storage/buffer protein present in the sarcoplasmic reticulum of both skeletal (CASQ1) and cardiac (CASQ2) muscles...
- CASQ1 gene is an unlikely candidate for malignant hyperthermia susceptibility in the North American populationNatalia Kraeva
Malignant Hyperthermia Investigation Unit, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
Anesthesiology 118:344-9. 2013..Studies of CASQ1-null mice have shown that CASQ1, encoding calsequestrin 1, the major Ca2+ binding protein in the lumen of the sarcoplasmic reticulum, is a candidate gene for MH in ..
- Mechanism of calsequestrin regulation of single cardiac ryanodine receptor in normal and pathological conditionsHaiyan Chen
Department of Molecular Physiology and Biophysics, Rush University Medical Center, Chicago, IL 60612, USA
J Gen Physiol 142:127-36. 2013..release through mechanisms localized inside the SR; one of these involves luminal Ca(2+) interacting with calsequestrin (CASQ), triadin, and/or junctin to regulate RyR2 function...
- Novel details of calsequestrin gel conformation in situStefano Perni
From the Department of Cell Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6058 and
J Biol Chem 288:31358-62. 2013b>Calsequestrin (CASQ) is the major component of the sarcoplasmic reticulum (SR) lumen in skeletal and cardiac muscles...
- Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden deathViktor Yarotskyy
Department of Physiology and Pharmacology, University of Rochester Medical Center, Rochester, New York, United States of America
PLoS ONE 8:e77633. 2013..anesthetic- and heat-induced sudden death: 1) type 1 ryanodine receptor (RyR1) knock-in mice (Y524S/+) and 2) calsequestrin 1 and 2 double knock-out (dCasq-null) mice...
- Calsequestrin (CASQ1) rescues function and structure of calcium release units in skeletal muscles of CASQ1-null miceMirta Tomasi
Dept of Experimental Biomedical Sciences, Univ of Padova, Italy
Am J Physiol Cell Physiol 302:C575-86. 2012..units, and molecular composition of sarcoplasmic reticulum (SR) are altered in fast-twitch skeletal muscles of calsequestrin-1 (CASQ1)-null mice...
- Glycosylation of skeletal calsequestrin: implications for its functionEmiliano J Sanchez
School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4660, USA
J Biol Chem 287:3042-50. 2012b>Calsequestrin (CASQ) serves as a major Ca(2+) storage/buffer protein in the sarcoplasmic reticulum (SR). When purified from skeletal muscle, CASQ1 is obtained in its glycosylated form...
- Development and testing of a cancer appetite and symptom questionnaireV Halliday
Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Nottingham, UK
J Hum Nutr Diet 25:217-24. 2012..The present study aimed to build on the CNAQ to develop a cancer appetite and symptom questionnaire (CASQ) for predicting weight loss in patients with cancer.
- Differential expression of calcium-regulating genes in heat-stressed turkey breast muscle is associated with meat qualityK R B Sporer
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, 48824, USA
Poult Sci 91:1418-24. 2012..sarco/endoplasmic reticulum Ca(2+)-ATPase 1 (SERCA1), and the sarcoplasmic reticulum, Ca(2+)-storage protein calsequestrin (CASQ1)...
- Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasisSimona Boncompagni
DNI Department of Neuroscience and Imaging, CeSI Center for Research on Ageing, University of G d Annunzio, Chieti, Italy
PLoS ONE 7:e39962. 2012..related transmembrane proteins thought to be key mediators of structural and functional interactions between calsequestrin (CASQ) and ryanodine receptor (RyRs) at the junctional sarcoplasmic reticulum (jSR)...
- Muscular degeneration in Duchenne's dystrophy may be caused by a mitochondrial defectB Lucas-Heron
Laboratoire de Physiologie, UER de Medecine, Nantes, France
Med Hypotheses 44:298-300. 1995..Our work on skeletal muscle has demonstrated a mitochondrial deficiency of the calcium-specific protein, calmitine, in degenerating muscle of myopathic persons and animals...
- Molecular cloning of human calmitine, a mitochondrial calcium binding protein, reveals identity with calsequestrineN Bataille
U 298 INSERM, CHR Angers, France
Biochem Biophys Res Commun 203:1477-82. 1994The cDNA of a mitochondrial calcium binding protein, "calmitine", has been cloned from a human skeletal muscle cDNA library. One cDNA of 1.8 kb has been isolated and sequenced...
- Mdx mouse skeletal muscle: could a mitochondrial factor be responsible for the absence of progressive necrosis?B Lucas-Heron
Laboratoire de Physiologie, Faculte de Medecine, Nantes, France
Neurosci Lett 169:97-100. 1994..of gastrocnemius muscle in X-related muscular dystrophy (mdx) and control mice relative to changes in calmitine and calcium concentrations before and 3 and 6 days after a single injection of the drug...
- Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genesK Otsu
Banting and Best Department of Medical Research, Charles H Best Institute, University of Toronto, Ontario, Canada
Genomics 17:507-9. 1993..1, the phospholamban gene (PLN) to 6q22.1, the human skeletal muscle calsequestrin gene (CASQ1) to band 1q21, the cardiac calsequestrin gene (CASQ2) to bands 1p11-p13...
- A drug inhibits the mitochondrial protease inducing calmitine deficiency in skeletal muscle of patients with Duchenne's muscular dystrophy and dy/dy dystrophic miceB Lucas-Heron
Groupe de Recherche sur les Myopathies, Laboratoire de Physiologie, UER de Medecine, Nantes, France
Biochem Biophys Res Commun 232:559-61. 1997This study demonstrates that the cause of calmitine deficiency in dy/dy dystrophic mice and patients with Duchenne's muscular dystrophy (DMD) is the same; i.e., the absence of an inhibitor of calmitine-specific mitochondrial protease...
- Regional alterations in SR Ca(2+)-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardiumJ A Fallavollita
Department of Veterans Affairs, Western New York Health Care System, Buffalo, New York 14214, USA
Am J Physiol 277:H1418-28. 1999..06, P < 0.02) and SR Ca(2+)-ATPase (0.83 +/- 0.06 vs. 1.02 +/- 0.06, P < 0.05) with no change in calsequestrin (1.08 +/- 0.06 vs. 0.96 +/- 0.05, P = not significant)...
- Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23K Doudney
Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, Du Cane Road, London, W12 ONN, United Kingdom
Genomics 72:180-92. 2001..Together, the physical and transcript maps described here serve as resources for the identification of the Lp mutation and further define the conservation of this genomic region between mouse and human...
- Structure and expression of Strabismus 1 gene on human chromosome 1q21-q23Masaru Katoh
Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
Int J Oncol 20:1197-203. 2002..Loss-of-function mutation of STB1 gene might lead to carcinogenesis through activation of the WNT - beta-catenin signaling pathway...
- Strabismus (STB)/Vang-like (VANGL) gene family (Review)Masaru Katoh
Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
Int J Mol Med 10:11-5. 2002..STB1 and STB2 might be suitable targets for tissue engineering in the field of re-generative medicine and for chemoprevention and treatment in the field of clinical oncology...
- Relationship of attributional style, depression, and posttrauma distress among children who suffered physical or sexual abuseMelissa K Runyon
Center for Children s Support, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford 08084, USA
Child Maltreat 7:254-64. 2002..the Post-Traumatic Stress Disorder-Reaction Index (PTSD-RI), and Children's Attributional Style Questionnaire (CASQ)...
- Maternal and child attributions in ADHD versus non-ADHD populationsBrent R Collett
Utah State University, USA
J Atten Disord 7:187-96. 2004..This study explores child and maternal attributions in ADHD and non-ADHD populations. Participants included children with ADHD (N = 26) and without ADHD (N = 24) and their mothers...
- Psychometric evaluation of a measure of Beck's negative cognitive triad for youth: applications for African-American and Caucasian adolescentsLeilani Greening
University of Mississippi Medical Center, Jackson, MS 39216, USA
Depress Anxiety 21:161-9. 2005..the CTI-C, the Children's Depression Inventory (CDI) and the Children's Attributional Style Questionnaire-Revised (CASQ-R) on two occasions 4 months apart. The CTI-C was found to be internally consistent, Cronbach's alpha=...
- [A controlled randomized trial of the use of combined L-carnitine and acetyl-L-carnitine treatment in men with oligoasthenozoospermia]Zheng Li
Department of Urology, Renji Hospital of Shanghai Second Medical Univesity, Shanghai 200001, China
Zhonghua Nan Ke Xue 11:761-4. 2005..To determine the efficacy and safety of combined L-carnitine and acetyl-L-carnitine therapy in infertile males with oligoasthenozoospermia...
- Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residuesLisa J Plummer
Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, Georgia 30602, USA
J Biol Chem 281:4596-605. 2006..RCE orthologs have conserved substrate specificity, cleaving CVIA, CTLM, and certain other CAAX motifs, but not the CASQ motif, when these motifs are placed in the context of the yeast a-factor precursor...
- Exercise-induced ventricular arrhythmias in patients with no structural cardiac diseaseMelvin M Scheinman
Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
Annu Rev Med 57:473-84. 2006..ventricular tachycardia due to abnormalities in either the ryanodine receptor 2 genes (RyR2) or the calsequestrin genes (CASQ)...
- Reduced expression of Ca2+-regulating proteins in the upper gastrointestinal tract of patients with achalasiaHarald Fischer
Medizinische Klinik und Poliklinik B, Universitatsklinikum Munster, Germany
World J Gastroenterol 12:6002-7. 2006..To compare expression of Ca(2+)-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia...
- Spin exchange effects on the physicochemical properties of tetraoxolene-bridged bimetallic complexesDong Guo
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
Inorg Chem 46:3257-74. 2007..chloranilate, have been prepared by two different routes from H2CA and H4CA starting materials; the corresponding (CAsq,cat)3- analogue was obtained by one-electron oxidation with decamethylferrocenium tetrafluoroborate...
- SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defectsSimona Vittorini
Molecular Cardiology and Genetics Laboratory, Institute of Clinical Physiology, National Research Council, G Pasquinucci Hospital, Massa, Italy
Mol Med 13:105-11. 2007..The gene expression of target genes was assessed semiquantitatively by RT-PCR using the calsequestrin (CASQ, a housekeeping gene) RNA as internal standard in the atrial myocardium of 23 pediatric patients ..
- Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillationMaura Greiser
Institut fur Physiologie, Universitatsklinikum Aachen, Aachen, Germany
Naunyn Schmiedebergs Arch Pharmacol 375:383-92. 2007..Ca(2+) channel subunit were determined using Western blot analysis and normalized to the protein amounts of calsequestrin as internal control...
- Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardiaLei Song
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
J Clin Invest 117:1814-23. 2007..ventricular tachycardia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestrin 2 (CASQ2) gene mutations...
- Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1Cecilia Paolini
IIM Interuniversity Institute of Myology, Ce S I Centro Science dell Invecchiamento, University G D Annunzio, I 66013 Chieti, Italy
J Physiol 583:767-84. 2007b>Calsequestrin (CS), the major Ca(2+)-binding protein in the sarcoplasmic reticulum (SR), is thought to play a dual role in excitation-contraction coupling: buffering free Ca(2+) increasing SR capacity, and modulating the activity of the ..
- Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whitesThomas Sparsø
Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820, Gentofte, Denmark
Mol Genet Metab 92:278-82. 2007b>Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells...
- Association analysis of chromosome 1 migraine candidate genesFrancesca Fernandez
Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
BMC Med Genet 8:57. 2007..In this study, we have undertaken a large genomic investigation involving candidate genes that lie within the chromosome 1q23 and 1q31 regions using an association analysis approach...
- Attitudes toward suicide among Chinese people in Hong KongSing Lee
Department of Psychiatry, Hong Kong Mood Disorders Center, Chinese Unviersity of Hong Kong, Shatin, NT, Hong Kong
Suicide Life Threat Behav 37:565-75. 2007..and quantitative methods, we developed a Hong Kong version of the Chinese Attitude toward Suicide Questionnaire (CASQ-HK) which assesses attitudes toward suicide, suicidal inclination under 12 hypothetical scenarios, and prior ..
- The Cleveland adolescent sleepiness questionnaire: a new measure to assess excessive daytime sleepiness in adolescentsJames C Spilsbury
Department of Pediatrics, Division of Clinical Epidemiology and Biostatistics, Case School of Medicine, Cleveland, OH 44106 6083, USA
J Clin Sleep Med 3:603-12. 2007Developed the Cleveland Adolescent Sleepiness Questionnaire (CASQ), a brief, self-completed instrument to measure excessive daytime sleepiness in adolescents.
- Type 2 diabetes susceptibility genes on chromosome 1q21-24S J Hasstedt
Department of Human Genetics, University of Utah, 15 N 2030 E, Salt Lake City, UT 84112, USA
Ann Hum Genet 72:163-9. 2008..The significant variant pairs were apolipoprotein A-II (APOA2) rs6413453 interacting with calsequestrin 1 (CASQ1) rs617698, dual specificity phosphatase 12 (DUSP12) rs1503814, and retinoid X receptor gamma (RXRG) ..
- Polymorphisms in multiple genes are associated with resting heart rate in a stepwise allele-dependent mannerStephen B Wilton
Libin Cardiovascular Institute, University of Calgary, Alberta, Canada
Heart Rhythm 5:694-700. 2008..The purpose of this study was to use a candidate gene approach to identify common polymorphisms that are associated with resting sinus heart rate in a population without overt cardiovascular disease...
- Ventricular arrhythmias after left ventricular assist device implantationMarwan Refaat
Divisions of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Pacing Clin Electrophysiol 31:1246-52. 2008..Despite the increasing use of LVAD, little is known regarding post-LVAD VAs at the molecular level and in vivo...
- Increased mitochondrial Ca2+ and decreased sarcoplasmic reticulum Ca2+ in mitochondrial myopathyJan Aydin
Present address Max Planck Institute for Biology of Ageing, Gleueler Str 50a, Cologne, Germany
Hum Mol Genet 18:278-88. 2009..sarcoplasmic reticulum (SR) Ca(2+) storage capacity in Tfam KO muscles due to a decreased expression of calsequestrin-1...
- Are genuine changes in protein expression being overlooked? Reassessing Western blottingJanelle P Mollica
Department of Zoology, La Trobe University, Melbourne, VIC 3086, Australia
Anal Biochem 386:270-5. 2009This study used purified calsequestrin 1 and AMP kinase (AMPK) proteins to demonstrate how Western blotting outcomes can be influenced when either the density of proteins detected lie within a nonproportional region of a standard curve ..
- Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout miceMarco Dainese
Ce S I Department of Basic and Applied Medical Sciences, Interuniversity Institute of Myology, University G D Annunzio, I 66013 Chieti, Italy
FASEB J 23:1710-20. 2009b>Calsequestrin-1 (CASQ1) is a moderate-affinity, high-capacity Ca(2+)-binding protein in the sarcoplasmic reticulum (SR) terminal cisternae of skeletal muscle...
- Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumenNicole A Beard
John Curtin School of Medical Research, Australian National University, ACT, Australia
Clin Exp Pharmacol Physiol 36:340-5. 2009..Until recently, how calsequestrin communicated the store Ca(2+) load to the RyR remained unknown. 3. Calsequestrin 1 (skeletal calsequestrin) has been shown to both inhibit and activate the skeletal RyR1, dependent on whether ..
- Expression of intracellular calcium signalling genes in cattle skin during tick infestationN Bagnall
CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia QLD, Australia
Parasite Immunol 31:177-87. 2009..The elevated expression in HR skin of specific Ca(2+) signalling genes such as AHNAK, CASQ, IL2, NFAT2CIP and PLCG1 may be related to host resistance...
- Calsequestrin-1: a new candidate gene for malignant hyperthermia and exertional/environmental heat strokeFeliciano Protasi
Centro Scienze dell Invecchiamento, Department of Basic and Applied Medical Sciences, Interuniversity Institute of Myology, University G D Annunzio, Chieti, Italy
J Physiol 587:3095-100. 2009..In our laboratory we have recently characterized a novel knockout model lacking skeletal muscle calsequestrin (CASQ1), a SR Ca(2+)-binding protein that modulates RyR1 function, and investigated whether these mice present ..
- Expression of calsequestrin in atrial and ventricular muscle of thermally acclimated rainbow troutHanna Korajoki
University of Joensuu, Faculty of Biosciences, Joensuu, Finland
J Exp Biol 212:3403-14. 2009b>Calsequestrin (CASQ) is the main Ca(2+) binding protein within the sarcoplasmic reticulum (SR) of the vertebrate heart...
- Can autoimmunity against calsequestrin explain the eye and eyelid muscle inflammation of thyroid eye disease?Bamini Gopinath
Department of Medicine, The University of Sydney, Nepean Clinical School, Penrith, NSW, Australia
Orbit 28:256-61. 2009..The main antigen appears to be the calcium binding protein calsequestrin. In this study we have tested for T lymphocyte sensitization to calsequestrin in patients with Graves' disease,..
- Exertional Rhabdomyolysis and Malignant Hyperthermia in a Patient with Ryanodine Receptor Type 1 Gene, L-type Calcium Channel alpha-1 Subunit Gene, and Calsequestrin-1 Gene PolymorphismsJohn F Capacchione
Assistant Professor, section sign Professor, Department of Anesthesiology, Department of Neurosurgery, National Naval Medical Center, Bethesda, Department of Surgery, Walter Reed Army Medical Center, Washington, D C
Anesthesiology 112:239-44. 2010
- The cardiac calsequestrin gene (CASQ2) is up-regulated in the thyroid in patients with Graves' ophthalmopathy--support for a role of autoimmunity against calsequestrin as the triggering eventLeon Wescombe
Department of Medicine, Nepean Clinical School, The University of Sydney, Penrith, NSW, Australia
Clin Endocrinol (Oxf) 73:522-8. 2010..The aim of this study was to identify differentially expressed genes within the thyroid of patients with GO and GH as a possible explanation for a thyroid initiated orbital autoimmunity...
- Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases?Jack R Wall
Department of Medicine, University of Sydney, Australia
Endokrynol Pol 61:222-7. 2010..other eye muscle and orbital connective tissue (OCT) antigens, in particular the calcium binding protein calsequestrin (CASQ1) and the orbital fibroblast membrane antigen collagen XIII...
- Epitopes, immunoglobulin classes and immunoglobulin G subclasses of calsequestrin antibodies in patients with thyroid eye diseaseSofie de Haan
Department of Medicine, Nepean Hospital, University of Sydney, Penrith, NSW, 2751, Australia
Autoimmunity 43:698-703. 2010..are associated with thyroid eye disease (TED), including those reactive against the calcium binding protein calsequestrin (CASQ)...
- Potential adverse interaction of human cardiac calsequestrinChulhee Kang
School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4660, USA
Eur J Pharmacol 646:12-21. 2010b>Calsequestrin (CASQ) is a major Ca(2+) storage protein within the sarcoplasmic reticulum (SR) of both cardiac and skeletal muscles...
- Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscleLeandro Royer
Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA
J Gen Physiol 136:325-38. 2010..requires a Ca(2+) reservoir of large capacity inside the sarcoplasmic reticulum (SR), presumably the protein calsequestrin. The buffering power of calsequestrin in vitro has a paradoxical dependence on [Ca(2+)] that should be ..
- Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expressionXiaoli Zhao
Department of Physiology and Biophysics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA
Biophys J 99:1556-64. 2010..Previously we showed that calsequestrin-1 (CSQ1) participated in retrograde regulation of SOCE in cultured skeletal myotubes...
- Molecular and functional analyses of aspolin, a fish-specific protein extremely rich in aspartic acidShigeharu Kinoshita
Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo, Tokyo, 113 8657, Japan
Mar Biotechnol (NY) 13:517-26. 2011..Injection of antisense morpholino oligo targeting both aspolins 1 and 2 increased the mRNA levels of calsequestrin 1, another calcium binding protein in SR...
- Mechanistic models for muscle diseases and disorders originating in the sarcoplasmic reticulumDavid H MacLennan
Banting and Best Department of Medical Research, University of Toronto, Charles H Best Institute, 112 College st Toronto, Ontario, Canada MSG 116
Biochim Biophys Acta 1813:948-64. 2011..ventricular tachycardia (CPVT), that resulted in the identification of the ryanodine receptor (RYR), calsequestrin (CASQ) and dihydropyridine receptor (CACNA1S) genes as sites of disease-causing mutations...
- Duplication of calsequestrin genes in teleosts: molecular characterization in the Senegalese sole (Solea senegalensis)Carlos Infante
IFAPA Centro El Toruño, 11500 El Puerto de Santa María Cádiz, Spain
Comp Biochem Physiol B Biochem Mol Biol 158:304-14. 2011b>Calsequestrin is a moderate-affinity, high-capacity Ca(2+) binding protein in the sarcoplasmic reticulum of skeletal and cardiac muscle that seems to act as an intralumenal Ca(2+) buffer...
- Probing cationic selectivity of cardiac calsequestrin and its CPVT mutantsNaresh C Bal
Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Biochem J 435:391-9. 2011CASQ (calsequestrin) is a Ca2+-buffering protein localized in the muscle SR (sarcoplasmic reticulum); however, it is unknown whether Ca2+ binding to CASQ2 is due to its location inside the SR rich in Ca2+ or due to its preference for Ca2+..
- Sequential stages in the age-dependent gradual formation and accumulation of tubular aggregates in fast twitch muscle fibers: SERCA and calsequestrin involvementSimona Boncompagni
IIM Interuniversitary Institute of Myology, DNI Department of Neuroscience and Imaging, CeSI Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, 66013, Chieti, Italy
Age (Dordr) 34:27-41. 2012..Initially (before 1 year of age), the SR Ca(2+) binding protein calsequestrin (CASQ) accumulates specifically at the I band level causing swelling of free SR cisternae...
- Couplons in rat atria form distinct subgroups defined by their molecular partnersMeredith N Schulson
Department of Cellular and Physiological Sciences, University of British Columbia, Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada
J Cell Sci 124:1167-74. 2011..triple-labelled enzymatically isolated fixed myocytes to examine the distribution and colocalization of RyR2, calsequestrin (Casq), voltage-gated Ca(2+) channels (Ca(v)1.2), the sodium-calcium exchanger (Ncx) and caveolin-3 (Cav3)...
- Phosphorylation of human calsequestrin: implications for calcium regulationEmiliano J Sanchez
School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4660, USA
Mol Cell Biochem 353:195-204. 2011Both cardiac and skeletal calsequestrin (CASQ2 and CASQ1) serve as a major Ca(2+) storage/buffer protein in the sarcoplasmic reticulum (SR) by sequestering and releasing large numbers of Ca(2+) ions during each muscular contraction and ..
- D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscleMonika Sztretye
Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA
J Gen Physiol 138:211-29. 2011..D4cpv was targeted to the SR by fusion with the cDNA of calsequestrin 1 or a variant that binds less Ca(2+)...
- Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscleMonika Sztretye
Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA
J Gen Physiol 138:231-47. 2011..In cells of mice null for Casq1, permeability did not decrease in the same way, indicating that calsequestrin (Casq) is essential in the mechanism of channel closure and termination of Ca(2+) release...
- Differential effect of calsequestrin ablation on structure and function of fast and slow skeletal muscle fibersCecilia Paolini
CeSI Center for Research on Ageing and DNI Department of Neuroscience and Imaging, Università Gabriele d Annunzio of Chieti, 66100 Chieti, Italy
J Biomed Biotechnol 2011:634075. 2011We compared structure and function of EDL and Soleus muscles in adult (4-6 m) mice lacking both Calsequestrin (CASQ) isoforms, the main SR Ca²⁺-binding proteins...
- Gene Targets of NKX 2.5 in the Conduction SystemMelvin Scheinman; Fiscal Year: 2004..MinK and HCN-1) in the pathogenesis of arrhythmias in the ventricular restricted knockout mouse model. This will be done by using in-situ hybridization and immunohistochemistry to follow the pattern of expression of these ion channels. ..
- Isaac N Pessah; Fiscal Year: 2016..In this way we assure that the outcome will be that the whole of this Program is greater than the sum of the individual parts. ..
- Prevention of depression among adolescents in IcelandW Craighead; Fiscal Year: 2004..or higher on CASQNEG; 3) scoring 25th percentile or lower on CAS-POS; OR, 4) scoring 25th percentile or lower on CASQ-POS minus CASQ-NEG...
- CHRONIC OBSTRUCTIVE PULMONARY DISEASE GENE LOCALIZATIONSANDRA HASSTEDT; Fiscal Year: 2002..Identifying a gene that when mutated increases the risk of COPD may increase understanding of pulmonary function, as well as allowing gene-carriers to be identified and made aware of their susceptibility. ..
- Developing Effective Treatments for Child Physical AbuseMELISSA RUNYON; Fiscal Year: 2005..Parent-Only CBT). Assessments will be conducted at pre- and post-treatment, and 3-month follow-up. ..
- MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASESANDRA HASSTEDT; Fiscal Year: 2009..In addition, this application proposes to implement changes to increase computational speed, allow data exploration, and facilitate data handling and analysis, while continuing to distribute and support PAP. ..