calsequestrin

Summary

Gene Symbol: calsequestrin
Description: calsequestrin 1
Alias: CASQ, PDIB1, VMCQA, calsequestrin-1, calmitin, calmitine, calsequestrin 1 (fast-twitch, skeletal muscle), calsequestrin, skeletal muscle isoform
Species: human

Top Publications

  1. ncbi Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish
    Mao Fu
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 53:3292-9. 2004
  2. pmc Identification of calcium binding sites on calsequestrin 1 and their implications for polymerization
    Amit Kumar
    CRS4, Bioengineering Group, Science and Technology Park Polaris, Piscina Manna, 09010 Pula, CA, Italy
    Mol Biosyst 9:1949-57. 2013
  3. doi Effectiveness of preventive family intervention in improving cognitive attributions among children of depressed parents: a randomized study
    Raija Leena Punamaki
    School of Social Sciences and Humanities Psychology, University of Tampere, Tampere, Finland
    J Fam Psychol 27:683-90. 2013
  4. pmc Endogenous and maximal sarcoplasmic reticulum calcium content and calsequestrin expression in type I and type II human skeletal muscle fibres
    C R Lamboley
    G D Lamb Department of Zoology, La Trobe University, Melbourne, Victoria 3086, Australia
    J Physiol 591:6053-68. 2013
  5. pmc A mutation in the CASQ1 gene causes a vacuolar myopathy with accumulation of sarcoplasmic reticulum protein aggregates
    Daniela Rossi
    Molecular Medicine Section, Department of Molecular and Developmental Medicine, University of Siena and Azienda Ospedaliera Universitaria Senese, Siena, 53100, Italy IIM, Interuniversity Institute of Myology
    Hum Mutat 35:1163-70. 2014
  6. doi Calsequestrins in skeletal and cardiac muscle from adult Danio rerio
    Sandra Furlan
    Institute of Neuroscience Consiglio Nazionale delle Ricerche, Viale G Colombo 3, 35121, Padua, Italy
    J Muscle Res Cell Motil 37:27-39. 2016
  7. doi Design Principles of Reptilian Muscles: Calcium Cycling Strategies
    Stefano Perni
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania
    Anat Rec (Hoboken) 299:352-60. 2016
  8. pmc Cancer Appetite and Symptom Questionnaire (CASQ) for Brazilian Patients: Cross-Cultural Adaptation and Validation Study
    Maria Cláudia Bernardes Spexoto
    Departamento de Alimentos e Nutrição, Faculdade de Ciências Farmacêuticas de Araraquara UNESP Univ Estadual Paulista, Rod Araraqura Jaú, km 01, Araraquara, Sao Paulo, Brazil
    PLoS ONE 11:e0156288. 2016
  9. ncbi The effect of taurine and β-alanine supplementation on taurine transporter protein and fatigue resistance in skeletal muscle from mdx mice
    Deanna M Horvath
    Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, Vic, 3086, Australia
    Amino Acids 48:2635-2645. 2016
  10. pmc An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood
    Haroon I Sheikh
    University of Western Ontario
    Pers Individ Dif 45:425-428. 2008

Research Grants

  1. Gene Targets of NKX 2.5 in the Conduction System
    Melvin Scheinman; Fiscal Year: 2004
  2. Isaac N Pessah; Fiscal Year: 2016
  3. Prevention of depression among adolescents in Iceland
    W Craighead; Fiscal Year: 2004
  4. CHRONIC OBSTRUCTIVE PULMONARY DISEASE GENE LOCALIZATION
    SANDRA HASSTEDT; Fiscal Year: 2002
  5. Developing Effective Treatments for Child Physical Abuse
    MELISSA RUNYON; Fiscal Year: 2005
  6. MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASE
    SANDRA HASSTEDT; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications104 found, 100 shown here

  1. ncbi Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish
    Mao Fu
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 53:3292-9. 2004
    b>Calsequestrin (CASQ)1 is involved in intracellular storage and release of calcium, a process that has been shown to mediate glucose transport in muscle...
  2. pmc Identification of calcium binding sites on calsequestrin 1 and their implications for polymerization
    Amit Kumar
    CRS4, Bioengineering Group, Science and Technology Park Polaris, Piscina Manna, 09010 Pula, CA, Italy
    Mol Biosyst 9:1949-57. 2013
    Biophysical studies have shown that each molecule of calsequestrin 1 (CASQ1) can bind about 70-80 Ca(2+) ions. However, the nature of Ca(2+)-binding sites has not yet been fully characterized...
  3. doi Effectiveness of preventive family intervention in improving cognitive attributions among children of depressed parents: a randomized study
    Raija Leena Punamaki
    School of Social Sciences and Humanities Psychology, University of Tampere, Tampere, Finland
    J Fam Psychol 27:683-90. 2013
    ..Children reported their cognitive attributions (CASQ-R, Children's Attributional Style Questionnaire-Revised (Thompson, Kaslow, Weiss, & Nolen-Hoeksema, 1998)), ..
  4. pmc Endogenous and maximal sarcoplasmic reticulum calcium content and calsequestrin expression in type I and type II human skeletal muscle fibres
    C R Lamboley
    G D Lamb Department of Zoology, La Trobe University, Melbourne, Victoria 3086, Australia
    J Physiol 591:6053-68. 2013
    The relationship between sarcoplasmic reticulum (SR) Ca(2+) content and calsequestrin (CSQ) isoforms was investigated in human skeletal muscle...
  5. pmc A mutation in the CASQ1 gene causes a vacuolar myopathy with accumulation of sarcoplasmic reticulum protein aggregates
    Daniela Rossi
    Molecular Medicine Section, Department of Molecular and Developmental Medicine, University of Siena and Azienda Ospedaliera Universitaria Senese, Siena, 53100, Italy IIM, Interuniversity Institute of Myology
    Hum Mutat 35:1163-70. 2014
    A missense mutation in the calsequestrin-1 gene (CASQ1) was found in a group of patients with a myopathy characterized by weakness, fatigue, and the presence of large vacuoles containing characteristic inclusions resulting from the ..
  6. doi Calsequestrins in skeletal and cardiac muscle from adult Danio rerio
    Sandra Furlan
    Institute of Neuroscience Consiglio Nazionale delle Ricerche, Viale G Colombo 3, 35121, Padua, Italy
    J Muscle Res Cell Motil 37:27-39. 2016
    b>Calsequestrin (Casq) is a high capacity, low affinity Ca(2+)-binding protein, critical for Ca(2+)-buffering in cardiac and skeletal muscle sarcoplasmic reticulum. All vertebrates have multiple genes encoding for different Casq isoforms...
  7. doi Design Principles of Reptilian Muscles: Calcium Cycling Strategies
    Stefano Perni
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania
    Anat Rec (Hoboken) 299:352-60. 2016
    ..Morphometric analysis demonstrates a pattern of increasing calsequestrin (CASQ) content in the lumen of SR from turtle to lizard, watersnake, and boa constrictor, and this content is ..
  8. pmc Cancer Appetite and Symptom Questionnaire (CASQ) for Brazilian Patients: Cross-Cultural Adaptation and Validation Study
    Maria Cláudia Bernardes Spexoto
    Departamento de Alimentos e Nutrição, Faculdade de Ciências Farmacêuticas de Araraquara UNESP Univ Estadual Paulista, Rod Araraqura Jaú, km 01, Araraquara, Sao Paulo, Brazil
    PLoS ONE 11:e0156288. 2016
    ..This study aimed to perform a cultural adaptation of the Cancer Appetite and Symptom Questionnaire (CASQ), into Portuguese and evaluate its psychometric properties on a sample of Brazilian cancer patients.
  9. ncbi The effect of taurine and β-alanine supplementation on taurine transporter protein and fatigue resistance in skeletal muscle from mdx mice
    Deanna M Horvath
    Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, Vic, 3086, Australia
    Amino Acids 48:2635-2645. 2016
    ..1 (RyR1), dihydropyridine receptor (DHPR), sarco(endo)plasmic reticulum Ca2+-ATPase 1 (SERCA1) or calsequestrin 1 (CSQ1)] between WT and mdx mice, and the expression of these proteins was not altered by taurine or β-..
  10. pmc An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood
    Haroon I Sheikh
    University of Western Ontario
    Pers Individ Dif 45:425-428. 2008
    ..completed a self-report measure of attributional styles, the Child Attributional Style Questionnaire-Revised (CASQ-R)...
  11. pmc Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice
    Barbara Mosca
    Department of Experimental and Diagnostic Medicine, General Pathology Section, University of Ferrara, Via Borsari 46, Ferrara 44121, Italy
    Nat Commun 4:1541. 2013
    ..JP45 is a membrane protein interacting with Ca(v)1.1 and the sarcoplasmic reticulum Ca(2+) storage protein calsequestrin (CASQ1). Here we show that JP45 and CASQ1 strengthen skeletal muscle contraction by modulating Ca(v)1...
  12. doi Dysferlin interacts with calsequestrin-1, myomesin-2 and dynein in human skeletal muscle
    Bàrbara Flix
    Servei de Neurologia, Laboratori de Neurologia Experimental, Hospital de la Santa Creu i Sant Pau i Institut de Recerca de HSCSP, Barcelona, Spain
    Int J Biochem Cell Biol 45:1927-38. 2013
    ..imaging showed a direct interaction of dysferlin with Trim72/MG53, AHNAK, cytoplasmic dynein, myomesin-2 and calsequestrin-1, but not with caveolin-3 or dystrophin...
  13. pmc Isobaric Tagging-Based Quantification for Proteomic Analysis: A Comparative Study of Spared and Affected Muscles from mdx Mice at the Early Phase of Dystrophy
    Cintia Yuri Matsumura
    Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    PLoS ONE 8:e65831. 2013
    ..The calcium-handling proteins sarcalumenin and calsequestrin-1 were increased in control EOM compared with control DIA, reinforcing the view that constitutional properties ..
  14. doi Distinct regions of triadin are required for targeting and retention at the junctional domain of the sarcoplasmic reticulum
    Daniela Rossi
    Department of Molecular and Developmental Medicine, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Biochem J 458:407-17. 2014
    ..multiprotein complex containing the RyR (ryanodine receptor) and additional proteins, including triadin and calsequestrin. The signals which drive these proteins to the j-SR and how they assemble to form this multiprotein complex ..
  15. doi Understanding the beneficial effects of doxycycline on the dystrophic phenotype of the mdx mouse
    Juliano Alves Pereira
    Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, 13083 865, Brazil
    Muscle Nerve 50:283-6. 2014
    ..The purpose of this study was to better understand the beneficial effects of doxycycline on the dystrophic muscles of the mdx mouse...
  16. pmc Differential skeletal muscle proteome of high- and low-active mice
    David P Ferguson
    Children s Nutritional Research Center, Baylor College of Medicine, Houston, Texas
    J Appl Physiol (1985) 116:1057-67. 2014
    ..g., annexin A6, P = 0.0031; calsequestrin 1; P = 0...
  17. pmc Resiliency training in Indian children: a pilot investigation of the Penn Resiliency Program
    Aruna Sankaranarayanan
    Director Prayatna 57, Prithvi Avenue, Chennai 600018, India
    Int J Environ Res Public Health 11:4125-39. 2014
    ..An Analysis of Covariance comparing post-test scores on Children's Attributional Style Questionnaire (CASQ) while controlling for baseline scores indicated that children in the intervention group exhibited a significant ..
  18. pmc An association study of CASQ1 gene polymorphisms and heat stroke
    Ying Li
    Department of Radiology, Chinese PLA Medical School, Beijing 100853, China
    Genomics Proteomics Bioinformatics 12:127-32. 2014
    ..conditions have not yet been elucidated, a novel disease-associated gene encoding a calcium-binding protein, calsequestrin-1 (CASQ1), was suggested relevant based on results from a transgenic murine model...
  19. pmc The C-terminal calcium-sensitive disordered motifs regulate isoform-specific polymerization characteristics of calsequestrin
    Naresh C Bal
    Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, 43210
    Biopolymers 103:15-22. 2015
    b>Calsequestrin (CASQ) exists as two distinct isoforms CASQ1 and CASQ2 in all vertebrates. Although the isoforms exhibit unique functional characteristic, the structural basis for the same is yet to be fully defined...
  20. doi The disorders of the calcium release unit of skeletal muscles: what have we learned from mouse models?
    Marta Canato
    Department of Biomedical Sciences, Laboratory of Physiology, University of Padova, Via Marzolo 3, 35131, Padua, Italy
    J Muscle Res Cell Motil 36:61-9. 2015
    ..called Calcium Release Unit and composed of DiHydroPyridine Receptor or DHPR, Ryanodine Receptor or RYR, Calsequestrin or CASQ, junctin, Triadin, Junctophilin and Mitsugumin 29...
  21. pmc Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death
    Antonio Michelucci
    From the Center for Research on Ageing and Department of Neuroscience, Imaging and Clinical Sciences, University G d Annunzio of Chieti, Chieti, Italy A M, C P, L P, A D M, F P Department of Biomedical Sciences, University of Padova, Padova, Italy M C, C R and Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York L W L, R T D
    Anesthesiology 123:603-17. 2015
    Mice lacking calsequestrin-1 (CASQ1-null), a Ca-binding protein that modulates the activity of Ca release in the skeletal muscle, exhibit lethal hypermetabolic episodes that resemble malignant hyperthermia in humans when exposed to ..
  22. doi A CASQ1 founder mutation in three Italian families with protein aggregate myopathy and hyperCKaemia
    Claudia Di Blasi
    Neuromuscular Diseases and Neuroimmunology Unit, Foundation IRCCS Neurological Institute C Besta, Milano, Italy
    J Med Genet 52:617-26. 2015
    ..Familial idiopathic hyperCKaemia is a benign genetically heterogeneous condition with autosomal dominant features in a high proportion of cases...
  23. pmc Characterization of Two Human Skeletal Calsequestrin Mutants Implicated in Malignant Hyperthermia and Vacuolar Aggregate Myopathy
    Kevin M Lewis
    From the Department of Chemistry, Washington State University, Pullman, Washington 99164 4630
    J Biol Chem 290:28665-74. 2015
    b>Calsequestrin 1 is the principal Ca(2+) storage protein of the sarcoplasmic reticulum of skeletal muscle...
  24. pmc Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles
    Barbara Mosca
    Department of Life Science and Biotechnology, University of Ferrara, Via Borsari 46, 44100, Ferrara, Italy
    J Biol Chem 291:14555-65. 2016
    We exploited a variety of mouse models to assess the roles of JP45-CASQ1 (CASQ, calsequestrin) and JP45-CASQ2 on calcium entry in slow twitch muscles...
  25. pmc Characterization of Post-Translational Modifications to Calsequestrins of Cardiac and Skeletal Muscle
    Kevin M Lewis
    Department of Chemistry, Washington State University, Pullman, WA 99164, USA
    Int J Mol Sci 17:. 2016
    b>Calsequestrin is glycosylated and phosphorylated during its transit to its final destination in the junctional sarcoplasmic reticulum...
  26. ncbi Sequencing of genes involved in the movement of calcium across human skeletal muscle sarcoplasmic reticulum: continuing the search for genes associated with malignant hyperthermia
    A R Bjorksten
    Senior Scientist, Malignant Hyperthermia Diagnostic Unit, Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Anaesthesia, Perioperative and Pain Medicine Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Victorian Clinical Genetics Service Molecular Genetics Laboratory, Murdoch Children s Research Institut
    Anaesth Intensive Care 44:762-768. 2016
    ..Nevertheless they provide the basis for a new set of functional studies, which may indeed identify novel players in MH...
  27. pmc DNA Hypomethylation in Intragenic and Intergenic Enhancer Chromatin of Muscle-Specific Genes Usually Correlates with their Expression
    Kenneth C Ehrlich
    Program in Bioinformatics and Genomics, Tulane University Health Sciences Center, New Orleans, LA
    Yale J Biol Med 89:441-455. 2016
    ..Our study suggests that DNA hypomethylation increases enhancer tissue-specificity and that SkM super-enhancers sometimes are poised for physiologically important, rapid up-regulation...
  28. doi Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only
    Giorgia Valle
    Dipartimento di Scienze Biomediche dell Università di Padova, Istituto Interuniversitario di Miologia, Viale G Colombo 3, 35121, Padova, Italy
    J Muscle Res Cell Motil . 2017
    ..CASQ2-/- causes increase in calsequestrin 1 (CASQ1) expression, but without functional changes in both muscle types...
  29. ncbi Characterization and localization to human chromosome 1 of human fast-twitch skeletal muscle calsequestrin gene
    J Fujii
    Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada
    Somat Cell Mol Genet 16:185-9. 1990
    A genomic clone encoding human fast-twitch skeletal muscle calsequestrin was isolated, and the amino acid sequence of the protein and the exon-intron boundaries of the gene were deduced from its sequence...
  30. ncbi Skeletal muscle of patients with Duchenne's muscular dystrophy: evidence of a mitochondrial proteolytic factor responsible for calmitine deficiency
    B Lucas-Heron
    Groupe de Recherche sur les Myopathies, Laboratoire de Physiologie, U E R de Médecine, Nantes, France
    Biochem Biophys Res Commun 223:31-5. 1996
    ..of mitochondrial extracts of skeletal muscle obtained from patients with Duchenne's muscular dystrophy (DMD) on calmitine of the mitochondrial matrix isolated from skeletal muscle of control mice...
  31. ncbi Linkage and radiation hybrid mapping of the porcine calsequestrin 1 (CASQ1 ) gene to chromosome 4q
    A Knoll
    Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, 277 21 Libechov, Czech Republic
    Anim Genet 33:390-2. 2002
  32. ncbi Clinically active serologically quiescent systemic lupus erythematosus
    Dafna D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5 034, Toronto, Ontario, Canada M5T 2S8
    J Rheumatol 30:1960-2. 2003
    To identify the frequency and characteristics of clinical activity with serological quiescence (CASQ) in a large cohort of patients with systemic lupus erythematosus (SLE) followed prospectively at a single center.
  33. ncbi Calsquestrin 1 (CASQ1) gene polymorphisms under chromosome 1q21 linkage peak are associated with type 2 diabetes in Northern European Caucasians
    Swapan Kumar Das
    Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Diabetes 53:3300-6. 2004
    ..We identified two SNPs that showed strong associations, and both mapped to within intron 2 of the calsequestrin 1 (CASQ1) gene...
  34. doi Potential regulatory role of calsequestrin in platelet Ca(2+) homeostasis and its association with platelet hyperactivity in diabetes mellitus
    Z Zhu
    Department of Pharmacology, Capital Medical University, Beijing, China
    J Thromb Haemost 10:116-24. 2012
    Altered Ca(2+) homeostasis contributes significantly to platelet hyperactivity in diabetes mellitus. Calsequestrin (CSQ), as a Ca(2+) buffer protein in the sarcoplasmic reticulum, also regulates the Ca(2+) release process in muscles...
  35. pmc High-capacity Ca2+ binding of human skeletal calsequestrin
    Emiliano J Sanchez
    School of Molecular Biosciences, Washington State University, Pullman, Washington 99164, USA
    J Biol Chem 287:11592-601. 2012
    b>Calsequestrin, the major calcium storage protein in both cardiac and skeletal muscle, binds large amounts of Ca(2+) in the sarcoplasmic reticulum and releases them during muscle contraction...
  36. pmc Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast-twitch muscle
    Andres Hernandez
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Physiol 590:3575-83. 2012
    ..changes in nitrate treated mice were accompanied by increased expression of the Ca(2+) handling proteins calsequestrin 1 and the dihydropyridine receptor...
  37. doi Both short intense and prolonged moderate in vitro stimulation reduce the mRNA expression of calcium-regulatory proteins in rat skeletal muscle
    Satu Mänttäri
    Department of Biology, University of Oulu, P O Box 3000, 90014 Oulu, Finland
    Mol Cell Biochem 373:171-8. 2013
    ..The mRNA level of Ca(2+)-ATPase (SERCA1, 2), calsequestrin (CASQ1, 2), ryanodine receptor (RyR1), and dihydropyridine receptor (Cacna1) was assessed in rat extensor ..
  38. pmc Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle
    Carlo Manno
    Section of Cellular Signaling Department of Molecular Biophysics and Physiology, Rush University School of Medicine, 1750 W Harrison St, Chicago, IL 60612, USA
    J Physiol 591:423-42. 2013
    ..6). The difference suggests that 75% of the releasable calcium is normally bound to calsequestrin. In the nulls the difference in B between ON and OFF was less than in the WT but still significant...
  39. pmc Molecular mechanisms of pharmaceutical drug binding into calsequestrin
    Arun K Subra
    Department of Chemistry, Washington State University, Pullman, WA 99164 4630, USA
    Int J Mol Sci 13:14326-43. 2012
    b>Calsequestrin (CASQ) is a major Ca2+-storage/buffer protein present in the sarcoplasmic reticulum of both skeletal (CASQ1) and cardiac (CASQ2) muscles...
  40. ncbi CASQ1 gene is an unlikely candidate for malignant hyperthermia susceptibility in the North American population
    Natalia Kraeva
    Malignant Hyperthermia Investigation Unit, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Anesthesiology 118:344-9. 2013
    ..Studies of CASQ1-null mice have shown that CASQ1, encoding calsequestrin 1, the major Ca2+ binding protein in the lumen of the sarcoplasmic reticulum, is a candidate gene for MH in ..
  41. pmc Mechanism of calsequestrin regulation of single cardiac ryanodine receptor in normal and pathological conditions
    Haiyan Chen
    Department of Molecular Physiology and Biophysics, Rush University Medical Center, Chicago, IL 60612, USA
    J Gen Physiol 142:127-36. 2013
    ..release through mechanisms localized inside the SR; one of these involves luminal Ca(2+) interacting with calsequestrin (CASQ), triadin, and/or junctin to regulate RyR2 function...
  42. pmc Novel details of calsequestrin gel conformation in situ
    Stefano Perni
    From the Department of Cell Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6058 and
    J Biol Chem 288:31358-62. 2013
    b>Calsequestrin (CASQ) is the major component of the sarcoplasmic reticulum (SR) lumen in skeletal and cardiac muscles...
  43. pmc Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death
    Viktor Yarotskyy
    Department of Physiology and Pharmacology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 8:e77633. 2013
    ..anesthetic- and heat-induced sudden death: 1) type 1 ryanodine receptor (RyR1) knock-in mice (Y524S/+) and 2) calsequestrin 1 and 2 double knock-out (dCasq-null) mice...
  44. doi Calsequestrin (CASQ1) rescues function and structure of calcium release units in skeletal muscles of CASQ1-null mice
    Mirta Tomasi
    Dept of Experimental Biomedical Sciences, Univ of Padova, Italy
    Am J Physiol Cell Physiol 302:C575-86. 2012
    ..units, and molecular composition of sarcoplasmic reticulum (SR) are altered in fast-twitch skeletal muscles of calsequestrin-1 (CASQ1)-null mice...
  45. pmc Glycosylation of skeletal calsequestrin: implications for its function
    Emiliano J Sanchez
    School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4660, USA
    J Biol Chem 287:3042-50. 2012
    b>Calsequestrin (CASQ) serves as a major Ca(2+) storage/buffer protein in the sarcoplasmic reticulum (SR). When purified from skeletal muscle, CASQ1 is obtained in its glycosylated form...
  46. doi Development and testing of a cancer appetite and symptom questionnaire
    V Halliday
    Division of Nutritional Sciences, School of Biosciences, University of Nottingham, Nottingham, UK
    J Hum Nutr Diet 25:217-24. 2012
    ..The present study aimed to build on the CNAQ to develop a cancer appetite and symptom questionnaire (CASQ) for predicting weight loss in patients with cancer.
  47. doi Differential expression of calcium-regulating genes in heat-stressed turkey breast muscle is associated with meat quality
    K R B Sporer
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, 48824, USA
    Poult Sci 91:1418-24. 2012
    ..sarco/endoplasmic reticulum Ca(2+)-ATPase 1 (SERCA1), and the sarcoplasmic reticulum, Ca(2+)-storage protein calsequestrin (CASQ1)...
  48. pmc Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis
    Simona Boncompagni
    DNI Department of Neuroscience and Imaging, CeSI Center for Research on Ageing, University of G d Annunzio, Chieti, Italy
    PLoS ONE 7:e39962. 2012
    ..related transmembrane proteins thought to be key mediators of structural and functional interactions between calsequestrin (CASQ) and ryanodine receptor (RyRs) at the junctional sarcoplasmic reticulum (jSR)...
  49. ncbi Muscular degeneration in Duchenne's dystrophy may be caused by a mitochondrial defect
    B Lucas-Heron
    Laboratoire de Physiologie, UER de Medecine, Nantes, France
    Med Hypotheses 44:298-300. 1995
    ..Our work on skeletal muscle has demonstrated a mitochondrial deficiency of the calcium-specific protein, calmitine, in degenerating muscle of myopathic persons and animals...
  50. ncbi Molecular cloning of human calmitine, a mitochondrial calcium binding protein, reveals identity with calsequestrine
    N Bataille
    U 298 INSERM, CHR Angers, France
    Biochem Biophys Res Commun 203:1477-82. 1994
    The cDNA of a mitochondrial calcium binding protein, "calmitine", has been cloned from a human skeletal muscle cDNA library. One cDNA of 1.8 kb has been isolated and sequenced...
  51. ncbi Mdx mouse skeletal muscle: could a mitochondrial factor be responsible for the absence of progressive necrosis?
    B Lucas-Heron
    Laboratoire de Physiologie, Faculte de Medecine, Nantes, France
    Neurosci Lett 169:97-100. 1994
    ..of gastrocnemius muscle in X-related muscular dystrophy (mdx) and control mice relative to changes in calmitine and calcium concentrations before and 3 and 6 days after a single injection of the drug...
  52. ncbi Chromosome mapping of five human cardiac and skeletal muscle sarcoplasmic reticulum protein genes
    K Otsu
    Banting and Best Department of Medical Research, Charles H Best Institute, University of Toronto, Ontario, Canada
    Genomics 17:507-9. 1993
    ..1, the phospholamban gene (PLN) to 6q22.1, the human skeletal muscle calsequestrin gene (CASQ1) to band 1q21, the cardiac calsequestrin gene (CASQ2) to bands 1p11-p13...
  53. ncbi A drug inhibits the mitochondrial protease inducing calmitine deficiency in skeletal muscle of patients with Duchenne's muscular dystrophy and dy/dy dystrophic mice
    B Lucas-Heron
    Groupe de Recherche sur les Myopathies, Laboratoire de Physiologie, UER de Medecine, Nantes, France
    Biochem Biophys Res Commun 232:559-61. 1997
    This study demonstrates that the cause of calmitine deficiency in dy/dy dystrophic mice and patients with Duchenne's muscular dystrophy (DMD) is the same; i.e., the absence of an inhibitor of calmitine-specific mitochondrial protease...
  54. ncbi Regional alterations in SR Ca(2+)-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium
    J A Fallavollita
    Department of Veterans Affairs, Western New York Health Care System, Buffalo, New York 14214, USA
    Am J Physiol 277:H1418-28. 1999
    ..06, P < 0.02) and SR Ca(2+)-ATPase (0.83 +/- 0.06 vs. 1.02 +/- 0.06, P < 0.05) with no change in calsequestrin (1.08 +/- 0.06 vs. 0.96 +/- 0.05, P = not significant)...
  55. ncbi Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23
    K Doudney
    Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, Du Cane Road, London, W12 ONN, United Kingdom
    Genomics 72:180-92. 2001
    ..Together, the physical and transcript maps described here serve as resources for the identification of the Lp mutation and further define the conservation of this genomic region between mouse and human...
  56. ncbi Structure and expression of Strabismus 1 gene on human chromosome 1q21-q23
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 20:1197-203. 2002
    ..Loss-of-function mutation of STB1 gene might lead to carcinogenesis through activation of the WNT - beta-catenin signaling pathway...
  57. ncbi Strabismus (STB)/Vang-like (VANGL) gene family (Review)
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 10:11-5. 2002
    ..STB1 and STB2 might be suitable targets for tissue engineering in the field of re-generative medicine and for chemoprevention and treatment in the field of clinical oncology...
  58. ncbi Relationship of attributional style, depression, and posttrauma distress among children who suffered physical or sexual abuse
    Melissa K Runyon
    Center for Children s Support, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford 08084, USA
    Child Maltreat 7:254-64. 2002
    ..the Post-Traumatic Stress Disorder-Reaction Index (PTSD-RI), and Children's Attributional Style Questionnaire (CASQ)...
  59. ncbi Maternal and child attributions in ADHD versus non-ADHD populations
    Brent R Collett
    Utah State University, USA
    J Atten Disord 7:187-96. 2004
    ..This study explores child and maternal attributions in ADHD and non-ADHD populations. Participants included children with ADHD (N = 26) and without ADHD (N = 24) and their mothers...
  60. ncbi Psychometric evaluation of a measure of Beck's negative cognitive triad for youth: applications for African-American and Caucasian adolescents
    Leilani Greening
    University of Mississippi Medical Center, Jackson, MS 39216, USA
    Depress Anxiety 21:161-9. 2005
    ..the CTI-C, the Children's Depression Inventory (CDI) and the Children's Attributional Style Questionnaire-Revised (CASQ-R) on two occasions 4 months apart. The CTI-C was found to be internally consistent, Cronbach's alpha=...
  61. ncbi [A controlled randomized trial of the use of combined L-carnitine and acetyl-L-carnitine treatment in men with oligoasthenozoospermia]
    Zheng Li
    Department of Urology, Renji Hospital of Shanghai Second Medical Univesity, Shanghai 200001, China
    Zhonghua Nan Ke Xue 11:761-4. 2005
    ..To determine the efficacy and safety of combined L-carnitine and acetyl-L-carnitine therapy in infertile males with oligoasthenozoospermia...
  62. pmc Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues
    Lisa J Plummer
    Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, Georgia 30602, USA
    J Biol Chem 281:4596-605. 2006
    ..RCE orthologs have conserved substrate specificity, cleaving CVIA, CTLM, and certain other CAAX motifs, but not the CASQ motif, when these motifs are placed in the context of the yeast a-factor precursor...
  63. ncbi Exercise-induced ventricular arrhythmias in patients with no structural cardiac disease
    Melvin M Scheinman
    Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Annu Rev Med 57:473-84. 2006
    ..ventricular tachycardia due to abnormalities in either the ryanodine receptor 2 genes (RyR2) or the calsequestrin genes (CASQ)...
  64. pmc Reduced expression of Ca2+-regulating proteins in the upper gastrointestinal tract of patients with achalasia
    Harald Fischer
    Medizinische Klinik und Poliklinik B, Universitatsklinikum Munster, Germany
    World J Gastroenterol 12:6002-7. 2006
    ..To compare expression of Ca(2+)-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia...
  65. ncbi Spin exchange effects on the physicochemical properties of tetraoxolene-bridged bimetallic complexes
    Dong Guo
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Inorg Chem 46:3257-74. 2007
    ..chloranilate, have been prepared by two different routes from H2CA and H4CA starting materials; the corresponding (CAsq,cat)3- analogue was obtained by one-electron oxidation with decamethylferrocenium tetrafluoroborate...
  66. pmc SERCA2a, phospholamban, sarcolipin, and ryanodine receptors gene expression in children with congenital heart defects
    Simona Vittorini
    Molecular Cardiology and Genetics Laboratory, Institute of Clinical Physiology, National Research Council, G Pasquinucci Hospital, Massa, Italy
    Mol Med 13:105-11. 2007
    ..The gene expression of target genes was assessed semiquantitatively by RT-PCR using the calsequestrin (CASQ, a housekeeping gene) RNA as internal standard in the atrial myocardium of 23 pediatric patients ..
  67. ncbi Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation
    Maura Greiser
    Institut fur Physiologie, Universitatsklinikum Aachen, Aachen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 375:383-92. 2007
    ..Ca(2+) channel subunit were determined using Western blot analysis and normalized to the protein amounts of calsequestrin as internal control...
  68. pmc Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia
    Lei Song
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 117:1814-23. 2007
    ..ventricular tachycardia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestrin 2 (CASQ2) gene mutations...
  69. pmc Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1
    Cecilia Paolini
    IIM Interuniversity Institute of Myology, Ce S I Centro Science dell Invecchiamento, University G D Annunzio, I 66013 Chieti, Italy
    J Physiol 583:767-84. 2007
    b>Calsequestrin (CS), the major Ca(2+)-binding protein in the sarcoplasmic reticulum (SR), is thought to play a dual role in excitation-contraction coupling: buffering free Ca(2+) increasing SR capacity, and modulating the activity of the ..
  70. ncbi Studies of association of the CASQ1 rs2275703 polymorphism in relation to type 2 diabetes and related quantitative metabolic traits among 7,088 Danish whites
    Thomas Sparsø
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820, Gentofte, Denmark
    Mol Genet Metab 92:278-82. 2007
    b>Calsequestrin 1 (CASQ1) is a calcium storage protein of fast-twitch skeletal muscle cells...
  71. pmc Association analysis of chromosome 1 migraine candidate genes
    Francesca Fernandez
    Genomics Research Centre, School of Health Science, Griffith University, Gold Coast, Queensland, Australia
    BMC Med Genet 8:57. 2007
    ..In this study, we have undertaken a large genomic investigation involving candidate genes that lie within the chromosome 1q23 and 1q31 regions using an association analysis approach...
  72. ncbi Attitudes toward suicide among Chinese people in Hong Kong
    Sing Lee
    Department of Psychiatry, Hong Kong Mood Disorders Center, Chinese Unviersity of Hong Kong, Shatin, NT, Hong Kong
    Suicide Life Threat Behav 37:565-75. 2007
    ..and quantitative methods, we developed a Hong Kong version of the Chinese Attitude toward Suicide Questionnaire (CASQ-HK) which assesses attitudes toward suicide, suicidal inclination under 12 hypothetical scenarios, and prior ..
  73. pmc The Cleveland adolescent sleepiness questionnaire: a new measure to assess excessive daytime sleepiness in adolescents
    James C Spilsbury
    Department of Pediatrics, Division of Clinical Epidemiology and Biostatistics, Case School of Medicine, Cleveland, OH 44106 6083, USA
    J Clin Sleep Med 3:603-12. 2007
    Developed the Cleveland Adolescent Sleepiness Questionnaire (CASQ), a brief, self-completed instrument to measure excessive daytime sleepiness in adolescents.
  74. doi Type 2 diabetes susceptibility genes on chromosome 1q21-24
    S J Hasstedt
    Department of Human Genetics, University of Utah, 15 N 2030 E, Salt Lake City, UT 84112, USA
    Ann Hum Genet 72:163-9. 2008
    ..The significant variant pairs were apolipoprotein A-II (APOA2) rs6413453 interacting with calsequestrin 1 (CASQ1) rs617698, dual specificity phosphatase 12 (DUSP12) rs1503814, and retinoid X receptor gamma (RXRG) ..
  75. doi Polymorphisms in multiple genes are associated with resting heart rate in a stepwise allele-dependent manner
    Stephen B Wilton
    Libin Cardiovascular Institute, University of Calgary, Alberta, Canada
    Heart Rhythm 5:694-700. 2008
    ..The purpose of this study was to use a candidate gene approach to identify common polymorphisms that are associated with resting sinus heart rate in a population without overt cardiovascular disease...
  76. pmc Ventricular arrhythmias after left ventricular assist device implantation
    Marwan Refaat
    Divisions of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Pacing Clin Electrophysiol 31:1246-52. 2008
    ..Despite the increasing use of LVAD, little is known regarding post-LVAD VAs at the molecular level and in vivo...
  77. doi Increased mitochondrial Ca2+ and decreased sarcoplasmic reticulum Ca2+ in mitochondrial myopathy
    Jan Aydin
    Present address Max Planck Institute for Biology of Ageing, Gleueler Str 50a, Cologne, Germany
    Hum Mol Genet 18:278-88. 2009
    ..sarcoplasmic reticulum (SR) Ca(2+) storage capacity in Tfam KO muscles due to a decreased expression of calsequestrin-1...
  78. doi Are genuine changes in protein expression being overlooked? Reassessing Western blotting
    Janelle P Mollica
    Department of Zoology, La Trobe University, Melbourne, VIC 3086, Australia
    Anal Biochem 386:270-5. 2009
    This study used purified calsequestrin 1 and AMP kinase (AMPK) proteins to demonstrate how Western blotting outcomes can be influenced when either the density of proteins detected lie within a nonproportional region of a standard curve ..
  79. pmc Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice
    Marco Dainese
    Ce S I Department of Basic and Applied Medical Sciences, Interuniversity Institute of Myology, University G D Annunzio, I 66013 Chieti, Italy
    FASEB J 23:1710-20. 2009
    b>Calsequestrin-1 (CASQ1) is a moderate-affinity, high-capacity Ca(2+)-binding protein in the sarcoplasmic reticulum (SR) terminal cisternae of skeletal muscle...
  80. doi Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen
    Nicole A Beard
    John Curtin School of Medical Research, Australian National University, ACT, Australia
    Clin Exp Pharmacol Physiol 36:340-5. 2009
    ..Until recently, how calsequestrin communicated the store Ca(2+) load to the RyR remained unknown. 3. Calsequestrin 1 (skeletal calsequestrin) has been shown to both inhibit and activate the skeletal RyR1, dependent on whether ..
  81. doi Expression of intracellular calcium signalling genes in cattle skin during tick infestation
    N Bagnall
    CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia QLD, Australia
    Parasite Immunol 31:177-87. 2009
    ..The elevated expression in HR skin of specific Ca(2+) signalling genes such as AHNAK, CASQ, IL2, NFAT2CIP and PLCG1 may be related to host resistance...
  82. pmc Calsequestrin-1: a new candidate gene for malignant hyperthermia and exertional/environmental heat stroke
    Feliciano Protasi
    Centro Scienze dell Invecchiamento, Department of Basic and Applied Medical Sciences, Interuniversity Institute of Myology, University G D Annunzio, Chieti, Italy
    J Physiol 587:3095-100. 2009
    ..In our laboratory we have recently characterized a novel knockout model lacking skeletal muscle calsequestrin (CASQ1), a SR Ca(2+)-binding protein that modulates RyR1 function, and investigated whether these mice present ..
  83. doi Expression of calsequestrin in atrial and ventricular muscle of thermally acclimated rainbow trout
    Hanna Korajoki
    University of Joensuu, Faculty of Biosciences, Joensuu, Finland
    J Exp Biol 212:3403-14. 2009
    b>Calsequestrin (CASQ) is the main Ca(2+) binding protein within the sarcoplasmic reticulum (SR) of the vertebrate heart...
  84. ncbi Can autoimmunity against calsequestrin explain the eye and eyelid muscle inflammation of thyroid eye disease?
    Bamini Gopinath
    Department of Medicine, The University of Sydney, Nepean Clinical School, Penrith, NSW, Australia
    Orbit 28:256-61. 2009
    ..The main antigen appears to be the calcium binding protein calsequestrin. In this study we have tested for T lymphocyte sensitization to calsequestrin in patients with Graves' disease,..
  85. ncbi Exertional Rhabdomyolysis and Malignant Hyperthermia in a Patient with Ryanodine Receptor Type 1 Gene, L-type Calcium Channel alpha-1 Subunit Gene, and Calsequestrin-1 Gene Polymorphisms
    John F Capacchione
    Assistant Professor, section sign Professor, Department of Anesthesiology, Department of Neurosurgery, National Naval Medical Center, Bethesda, Department of Surgery, Walter Reed Army Medical Center, Washington, D C
    Anesthesiology 112:239-44. 2010
  86. doi The cardiac calsequestrin gene (CASQ2) is up-regulated in the thyroid in patients with Graves' ophthalmopathy--support for a role of autoimmunity against calsequestrin as the triggering event
    Leon Wescombe
    Department of Medicine, Nepean Clinical School, The University of Sydney, Penrith, NSW, Australia
    Clin Endocrinol (Oxf) 73:522-8. 2010
    ..The aim of this study was to identify differentially expressed genes within the thyroid of patients with GO and GH as a possible explanation for a thyroid initiated orbital autoimmunity...
  87. ncbi Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases?
    Jack R Wall
    Department of Medicine, University of Sydney, Australia
    Endokrynol Pol 61:222-7. 2010
    ..other eye muscle and orbital connective tissue (OCT) antigens, in particular the calcium binding protein calsequestrin (CASQ1) and the orbital fibroblast membrane antigen collagen XIII...
  88. doi Epitopes, immunoglobulin classes and immunoglobulin G subclasses of calsequestrin antibodies in patients with thyroid eye disease
    Sofie de Haan
    Department of Medicine, Nepean Hospital, University of Sydney, Penrith, NSW, 2751, Australia
    Autoimmunity 43:698-703. 2010
    ..are associated with thyroid eye disease (TED), including those reactive against the calcium binding protein calsequestrin (CASQ)...
  89. doi Potential adverse interaction of human cardiac calsequestrin
    Chulhee Kang
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4660, USA
    Eur J Pharmacol 646:12-21. 2010
    b>Calsequestrin (CASQ) is a major Ca(2+) storage protein within the sarcoplasmic reticulum (SR) of both cardiac and skeletal muscles...
  90. pmc Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle
    Leandro Royer
    Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA
    J Gen Physiol 136:325-38. 2010
    ..requires a Ca(2+) reservoir of large capacity inside the sarcoplasmic reticulum (SR), presumably the protein calsequestrin. The buffering power of calsequestrin in vitro has a paradoxical dependence on [Ca(2+)] that should be ..
  91. pmc Increased store-operated Ca2+ entry in skeletal muscle with reduced calsequestrin-1 expression
    Xiaoli Zhao
    Department of Physiology and Biophysics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA
    Biophys J 99:1556-64. 2010
    ..Previously we showed that calsequestrin-1 (CSQ1) participated in retrograde regulation of SOCE in cultured skeletal myotubes...
  92. doi Molecular and functional analyses of aspolin, a fish-specific protein extremely rich in aspartic acid
    Shigeharu Kinoshita
    Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo, Tokyo, 113 8657, Japan
    Mar Biotechnol (NY) 13:517-26. 2011
    ..Injection of antisense morpholino oligo targeting both aspolins 1 and 2 increased the mRNA levels of calsequestrin 1, another calcium binding protein in SR...
  93. doi Mechanistic models for muscle diseases and disorders originating in the sarcoplasmic reticulum
    David H MacLennan
    Banting and Best Department of Medical Research, University of Toronto, Charles H Best Institute, 112 College st Toronto, Ontario, Canada MSG 116
    Biochim Biophys Acta 1813:948-64. 2011
    ..ventricular tachycardia (CPVT), that resulted in the identification of the ryanodine receptor (RYR), calsequestrin (CASQ) and dihydropyridine receptor (CACNA1S) genes as sites of disease-causing mutations...
  94. doi Duplication of calsequestrin genes in teleosts: molecular characterization in the Senegalese sole (Solea senegalensis)
    Carlos Infante
    IFAPA Centro El Toruño, 11500 El Puerto de Santa María Cádiz, Spain
    Comp Biochem Physiol B Biochem Mol Biol 158:304-14. 2011
    b>Calsequestrin is a moderate-affinity, high-capacity Ca(2+) binding protein in the sarcoplasmic reticulum of skeletal and cardiac muscle that seems to act as an intralumenal Ca(2+) buffer...
  95. doi Probing cationic selectivity of cardiac calsequestrin and its CPVT mutants
    Naresh C Bal
    Department of Physiology and Cell Biology, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Biochem J 435:391-9. 2011
    CASQ (calsequestrin) is a Ca2+-buffering protein localized in the muscle SR (sarcoplasmic reticulum); however, it is unknown whether Ca2+ binding to CASQ2 is due to its location inside the SR rich in Ca2+ or due to its preference for Ca2+..
  96. pmc Sequential stages in the age-dependent gradual formation and accumulation of tubular aggregates in fast twitch muscle fibers: SERCA and calsequestrin involvement
    Simona Boncompagni
    IIM Interuniversitary Institute of Myology, DNI Department of Neuroscience and Imaging, CeSI Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, 66013, Chieti, Italy
    Age (Dordr) 34:27-41. 2012
    ..Initially (before 1 year of age), the SR Ca(2+) binding protein calsequestrin (CASQ) accumulates specifically at the I band level causing swelling of free SR cisternae...
  97. pmc Couplons in rat atria form distinct subgroups defined by their molecular partners
    Meredith N Schulson
    Department of Cellular and Physiological Sciences, University of British Columbia, Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada
    J Cell Sci 124:1167-74. 2011
    ..triple-labelled enzymatically isolated fixed myocytes to examine the distribution and colocalization of RyR2, calsequestrin (Casq), voltage-gated Ca(2+) channels (Ca(v)1.2), the sodium-calcium exchanger (Ncx) and caveolin-3 (Cav3)...
  98. doi Phosphorylation of human calsequestrin: implications for calcium regulation
    Emiliano J Sanchez
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4660, USA
    Mol Cell Biochem 353:195-204. 2011
    Both cardiac and skeletal calsequestrin (CASQ2 and CASQ1) serve as a major Ca(2+) storage/buffer protein in the sarcoplasmic reticulum (SR) by sequestering and releasing large numbers of Ca(2+) ions during each muscular contraction and ..
  99. pmc D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle
    Monika Sztretye
    Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA
    J Gen Physiol 138:211-29. 2011
    ..D4cpv was targeted to the SR by fusion with the cDNA of calsequestrin 1 or a variant that binds less Ca(2+)...
  100. pmc Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscle
    Monika Sztretye
    Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA
    J Gen Physiol 138:231-47. 2011
    ..In cells of mice null for Casq1, permeability did not decrease in the same way, indicating that calsequestrin (Casq) is essential in the mechanism of channel closure and termination of Ca(2+) release...
  101. pmc Differential effect of calsequestrin ablation on structure and function of fast and slow skeletal muscle fibers
    Cecilia Paolini
    CeSI Center for Research on Ageing and DNI Department of Neuroscience and Imaging, Università Gabriele d Annunzio of Chieti, 66100 Chieti, Italy
    J Biomed Biotechnol 2011:634075. 2011
    We compared structure and function of EDL and Soleus muscles in adult (4-6 m) mice lacking both Calsequestrin (CASQ) isoforms, the main SR Ca²⁺-binding proteins...

Research Grants6

  1. Gene Targets of NKX 2.5 in the Conduction System
    Melvin Scheinman; Fiscal Year: 2004
    ..MinK and HCN-1) in the pathogenesis of arrhythmias in the ventricular restricted knockout mouse model. This will be done by using in-situ hybridization and immunohistochemistry to follow the pattern of expression of these ion channels. ..
  2. Isaac N Pessah; Fiscal Year: 2016
    ..In this way we assure that the outcome will be that the whole of this Program is greater than the sum of the individual parts. ..
  3. Prevention of depression among adolescents in Iceland
    W Craighead; Fiscal Year: 2004
    ..or higher on CASQNEG; 3) scoring 25th percentile or lower on CAS-POS; OR, 4) scoring 25th percentile or lower on CASQ-POS minus CASQ-NEG...
  4. CHRONIC OBSTRUCTIVE PULMONARY DISEASE GENE LOCALIZATION
    SANDRA HASSTEDT; Fiscal Year: 2002
    ..Identifying a gene that when mutated increases the risk of COPD may increase understanding of pulmonary function, as well as allowing gene-carriers to be identified and made aware of their susceptibility. ..
  5. Developing Effective Treatments for Child Physical Abuse
    MELISSA RUNYON; Fiscal Year: 2005
    ..Parent-Only CBT). Assessments will be conducted at pre- and post-treatment, and 3-month follow-up. ..
  6. MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASE
    SANDRA HASSTEDT; Fiscal Year: 2009
    ..In addition, this application proposes to implement changes to increase computational speed, allow data exploration, and facilitate data handling and analysis, while continuing to distribute and support PAP. ..