CALR3

Summary

Gene Symbol: CALR3
Description: calreticulin 3
Alias: CMH19, CRT2, CT93, calreticulin-3, calreticulin-2, calsperin, cancer/testis antigen 93, testis secretory sperm-binding protein Li 226n
Species: human

Top Publications

  1. doi Systematic deletion of the ER lectin chaperone genes reveals their roles in vegetative growth and male gametophyte development in Arabidopsis
    Kien Van Vu
    Department of Molecular Biotechnology, College of Agriculture and Life Sciences, Bioenergy Research Institute, Chonnam National University, Gwangju, Republic of Korea
    Plant J . 2016
  2. pmc Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer
    Emeaga Maheswaran
    Department of Cancer and Inflammation Research, Institute for Molecular Medicine IMM, University of Southern Denmark, Odense, Denmark
    PLoS ONE 10:e0134967. 2015
  3. doi Molecular characterisation and expression analysis of a novel calreticulin (CRT) gene in the dinoflagellate Prorocentrum minimum
    Thangaraj Ponmani
    Department of Life Science, College of Natural Sciences, Sangmyung University, Seoul, 110 743, Korea
    Mol Biol Rep 42:681-8. 2015
  4. pmc Molecular cloning and transcriptional activity of a new Petunia calreticulin gene involved in pistil transmitting tract maturation, progamic phase, and double fertilization
    Robert Lenartowski
    Laboratory of Isotope and Instrumental Analysis, Faculty of Biology and Environment Protection, Nicolaus Copernicus University, Torun, Poland
    Planta 239:437-54. 2014
  5. doi Metabolic syndrome and acute hyperglycemia are associated with endoplasmic reticulum stress in human mononuclear cells
    Andrew T Sage
    Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 20:748-55. 2012
  6. pmc The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter
    Jeannette Abplanalp
    Institute of Medical Molecular Genetics, University of Zurich, Zurich, Switzerland
    Hum Mol Genet 22:3218-26. 2013
  7. pmc A conserved basic residue cluster is essential for the protein quality control function of the Arabidopsis calreticulin 3
    Yidan Liu
    Department of Molecular, Cellular, and Developmental Biology University of Michigan Ann Arbor, MI USA
    Plant Signal Behav 8:e23864. 2013
  8. pmc Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa
    Ryo Yamaguchi
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Mol Biol Cell 23:2671-9. 2012
  9. pmc Beyond the cardiac myofilament: hypertrophic cardiomyopathy- associated mutations in genes that encode calcium-handling proteins
    A P Landstrom
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Curr Mol Med 12:507-18. 2012
  10. pmc Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]
    Keizo Tokuhiro
    Research Institute for Microbial Diseases, University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 109:3850-5. 2012

Scientific Experts

  • Staffan Persson
  • Robert Lenartowski
  • Ryuji Nomura
  • Masahito Ikawa
  • Susanne Bens
  • Masaru Okabe
  • Kien Van Vu
  • Emeaga Maheswaran
  • Thangaraj Ponmani
  • Yidan Liu
  • Jeannette Abplanalp
  • Yongjian Qiu
  • Ryo Yamaguchi
  • Andrew T Sage
  • Keizo Tokuhiro
  • A P Landstrom
  • Yuko Muro
  • Yuanyuan Qiu
  • Cristina Martínez-Muñoz
  • Emiko Hayashi
  • Christine Chiu
  • Yong Hwa Lee
  • Chan Young Jeong
  • Ngoc Trinh Nguyen
  • Suk Whan Hong
  • Hojoung Lee
  • Jang Seu Ki
  • Christina B Pedersen
  • Henrik J Ditzel
  • Young Sang Suh
  • Morten F Gjerstorff
  • Ruoyu Guo
  • J G Valenzuela
  • Endre Laczko
  • Barbara Kloeckener-Gruissem
  • Francis L Munier
  • Daniel F Schorderet
  • Francois Verrey
  • Philipp Braun
  • John Neidhardt
  • Jurian Zuercher
  • Jianming Li
  • Wolfgang Berger
  • Simone M R Camargo
  • Nancy J Philp
  • M J Ackerman
  • Geoff H Werstuck
  • Sarah Holtby-Ottenhof
  • Yuanyuan Shi
  • Liqun Du
  • Sanja Roje
  • Adam M Benham
  • Yoshitaka Fujihara
  • Arya M Sharma
  • B W Poovaiah
  • Jing Xi
  • Suzana Damjanovic
  • Marek Michalak
  • Gajja S Salomons
  • Efraim H Rosenberg
  • Cornelis Jakobs
  • Laura Yeates
  • Sachiko Kurihara
  • Joanne M Lind
  • Tomonobu Fujita
  • Go Hasegawa
  • Yutaka Kawakami
  • Toshiro Kageshita
  • Tomonori Yaguchi
  • Christopher Semsarian
  • Jonathan W Arthur
  • Molly Tebo
  • Jodie Ingles
  • Yuriko Matsuzaki
  • Makoto Sano
  • M K Garfield
  • I M B Francischetti
  • V M Pham
  • J M C Ribeiro
  • L F Barnwell
  • G Chaudhuri
  • J G Townsel

Detail Information

Publications23

  1. doi Systematic deletion of the ER lectin chaperone genes reveals their roles in vegetative growth and male gametophyte development in Arabidopsis
    Kien Van Vu
    Department of Molecular Biotechnology, College of Agriculture and Life Sciences, Bioenergy Research Institute, Chonnam National University, Gwangju, Republic of Korea
    Plant J . 2016
    ..The Arabidopsis genome has two CNX (CNX1 and CNX2) and three CRT homologs (CRT1, CRT2, and CRT3)...
  2. pmc Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer
    Emeaga Maheswaran
    Department of Cancer and Inflammation Research, Institute for Molecular Medicine IMM, University of Southern Denmark, Odense, Denmark
    PLoS ONE 10:e0134967. 2015
    ..In this study, we investigated the expression of the cancer/testis antigens ADAM2, CALR3 and SAGE1 in lung and breast cancer, the two most frequent human cancers, with the purpose of providing novel ..
  3. doi Molecular characterisation and expression analysis of a novel calreticulin (CRT) gene in the dinoflagellate Prorocentrum minimum
    Thangaraj Ponmani
    Department of Life Science, College of Natural Sciences, Sangmyung University, Seoul, 110 743, Korea
    Mol Biol Rep 42:681-8. 2015
    ..Here, we characterised a novel calreticulin (CRT2) gene in the dinoflagellate Prorocentrum minimum, which codes for a calcium binding protein and examined its ..
  4. pmc Molecular cloning and transcriptional activity of a new Petunia calreticulin gene involved in pistil transmitting tract maturation, progamic phase, and double fertilization
    Robert Lenartowski
    Laboratory of Isotope and Instrumental Analysis, Faculty of Biology and Environment Protection, Nicolaus Copernicus University, Torun, Poland
    Planta 239:437-54. 2014
    ..with other known plant CRTs, and phylogenetic analysis indicates that the PhCRT cDNA clone belongs to the CRT1/CRT2 subclass...
  5. doi Metabolic syndrome and acute hyperglycemia are associated with endoplasmic reticulum stress in human mononuclear cells
    Andrew T Sage
    Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada
    Obesity (Silver Spring) 20:748-55. 2012
    ..These findings suggest that there is an association between both acute and chronic dysglycemia and ER stress in humans...
  6. pmc The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter
    Jeannette Abplanalp
    Institute of Medical Molecular Genetics, University of Zurich, Zurich, Switzerland
    Hum Mol Genet 22:3218-26. 2013
    ..Here, we identified a second creatine transporter (CRT2) known as monocarboxylate transporter 12 (MCT12), encoded by the cataract and glucosuria associated gene SLC16A12...
  7. pmc A conserved basic residue cluster is essential for the protein quality control function of the Arabidopsis calreticulin 3
    Yidan Liu
    Department of Molecular, Cellular, and Developmental Biology University of Michigan Ann Arbor, MI USA
    Plant Signal Behav 8:e23864. 2013
    ..Many plants contain more than two CRTs that form two distinct groups: CRT1/CRT2 and CRT3...
  8. pmc Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa
    Ryo Yamaguchi
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Mol Biol Cell 23:2671-9. 2012
    Eight kinds of gene-disrupted mice (Clgn, Calr3, Pdilt, Tpst2, Ace, Adam1a, Adam2, and Adam3) show impaired sperm transition into the oviducts and defective sperm binding to the zona pellucida...
  9. pmc Beyond the cardiac myofilament: hypertrophic cardiomyopathy- associated mutations in genes that encode calcium-handling proteins
    A P Landstrom
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Curr Mol Med 12:507-18. 2012
    ..In addition, mutations in RYR2-encoded ryanodine receptor 2, CASQ2-encoded calsequestrin 2, CALR3-encoded calreticulin 3, and SRI-encoded sorcin have been associated with HCM, although more studies are required to validate initial ..
  10. pmc Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]
    Keizo Tokuhiro
    Research Institute for Microbial Diseases, University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 109:3850-5. 2012
    ..protein disulfide isomerase homolog (PDILT) cooperates with the testis-specific calreticulin-like chaperone, calsperin (CALR3), in the endoplasmic reticulum and plays an indispensable role in the disulfide-bond formation and ..
  11. doi A dual regulatory role of Arabidopsis calreticulin-2 in plant innate immunity
    Yongjian Qiu
    Department of Horticulture, Washington State University, Pullman, WA 99164 6414, USA
    Plant J 69:489-500. 2012
    ..Higher plants contain two distinct groups of CRTs: CRT1/CRT2 and CRT3 isoforms...
  12. ncbi Toward a description of the sialome of the adult female mosquito Aedes aegypti
    J G Valenzuela
    Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4 126, Bethesda, MD 20892 0425, USA
    Insect Biochem Mol Biol 32:1101-22. 2002
    ..The possible role of these proteins in blood and sugar feeding by the mosquito is discussed...
  13. ncbi Cloning and sequencing of a cDNA encoding a novel member of the human brain GABA/noradrenaline neurotransmitter transporter family
    L F Barnwell
    Department of Physiology, Meharry Medical College, Nashville, TN 37208, USA
    Gene 159:287-8. 1995
    ..One identical to the published creatine transporter cDNA sequence (CRT1) and another (CRT2) with four segments of oligodeoxyribonucleotide substitution or addition in different sites of the CRT1 coding ..
  14. doi A de novo 1.1Mb microdeletion of chromosome 19p13.11 provides indirect evidence for EPS15L1 to be a strong candidate for split hand split foot malformation
    Susanne Bens
    Institute of Human Genetics, Christian Albrechts University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Germany
    Eur J Med Genet 54:e501-4. 2011
    ..is that in the previously described patient but not in the patient reported herein the genes EPS15L1 and CALR3 were deleted...
  15. doi Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2+ -binding protein
    Ryuji Nomura
    Department of Anatomy I, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Histochem Cell Biol 135:531-8. 2011
    ....
  16. pmc Calsperin is a testis-specific chaperone required for sperm fertility
    Masahito Ikawa
    Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 286:5639-46. 2011
    ..In the testis, calmegin (CLGN) and calsperin (CALR3) are expressed as germ cell-specific counterparts of CANX and CALR, respectively...
  17. doi Mechanisms of fertilization--a view from the study of gene-manipulated mice
    Yuko Muro
    Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    J Androl 32:218-25. 2011
    ..We have disrupted a new testis-specific molecular chaperone, calsperin (Calr3), which became the sixth gene sharing the same infertile phenotype...
  18. doi Transcriptional control of the calreticulin gene in health and disease
    Yuanyuan Qiu
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Int J Biochem Cell Biol 41:531-8. 2009
    ..Understanding the mechanisms responsible for the regulation of expression of calreticulin may contribute to the treatment of many diverse diseases...
  19. doi Identification, characterization and cloning of SLC6A8C, a novel splice variant of the creatine transporter gene
    Cristina Martínez-Muñoz
    VU University Medical Center, Department of Clinical Chemistry, Metabolic Unit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Gene 418:53-9. 2008
    ..Our goal was to characterize CRT2 (SLC6A8B), a published splice variant of the creatine transporter...
  20. ncbi Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis
    Emiko Hayashi
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Clin Cancer Res 13:6267-74. 2007
    ..Identification of additional cancer-testis antigens with frequent expression in various cancers was attempted using representational differential analysis (RDA) and immunogenicity evaluation...
  21. ncbi Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy
    Christine Chiu
    Agnes Ginges Centre for Molecular Cardiology, Centenary Institute, Sydney Australia
    J Mol Cell Cardiol 43:337-43. 2007
    ..sorcin (SRI), calstabin (FKBP1B), calsequestrin (CASQ2), phospholamban (PLN), sarcolipin (SLN), calreticulin (CALR3) and calmodulin (CALM)...
  22. pmc Phylogenetic analyses and expression studies reveal two distinct groups of calreticulin isoforms in higher plants
    Staffan Persson
    Department of Plant Biochemistry, Lund University, 22100 Lund, Sweden
    Plant Physiol 133:1385-96. 2003
    ..Phylogenetic studies and expression analysis show that higher plants contain two distinct groups of CRTs: a CRT1/CRT2 group and a CRT3 group...
  23. ncbi Identification of a novel calreticulin isoform (Crt2) in human and mouse
    Staffan Persson
    Department of Plant Biochemistry, Center for Chemistry and Chemical Engineering, Lund University, P O Box 124, SE 22100, Lund, Sweden
    Gene 297:151-8. 2002
    ..Here we report a novel calreticulin isoform (Crt2) in human and mouse, with 53 (human) and 49% (mouse) identity to the previously identified calreticulin in ..